BindingDB Reactant_set_id	Ligand SMILES	Ligand InChI	Ligand InChI Key	BindingDB MonomerID	BindingDB Ligand Name	Target Name	Target Source Organism According to Curator or DataSource	Ki (nM)	IC50 (nM)	Kd (nM)	EC50 (nM)	kon (M-1-s-1)	koff (s-1)	pH	Temp (C)	Curation/DataSource	Article DOI	BindingDB Entry DOI	PMID	PubChem AID	Patent Number	Authors	Date of publication	Date in BindingDB	Institution	Link to Ligand in BindingDB	Link to Target in BindingDB	Link to Ligand-Target Pair in BindingDB	Ligand HET ID in PDB	PDB ID(s) for Ligand-Target Complex	PubChem CID	PubChem SID	ChEBI ID of Ligand	ChEMBL ID of Ligand	DrugBank ID of Ligand	IUPHAR_GRAC ID of Ligand	KEGG ID of Ligand	ZINC ID of Ligand	Number of Protein Chains in Target (>1 implies a multichain complex)	BindingDB Target Chain Sequence 1	PDB ID(s) of Target Chain 1	UniProt (SwissProt) Recommended Name of Target Chain 1	UniProt (SwissProt) Entry Name of Target Chain 1	UniProt (SwissProt) Primary ID of Target Chain 1	UniProt (SwissProt) Secondary ID(s) of Target Chain 1	UniProt (SwissProt) Alternative ID(s) of Target Chain 1	UniProt (TrEMBL) Submitted Name of Target Chain 1	UniProt (TrEMBL) Entry Name of Target Chain 1	UniProt (TrEMBL) Primary ID of Target Chain 1	UniProt (TrEMBL) Secondary ID(s) of Target Chain 1	UniProt (TrEMBL) Alternative ID(s) of Target Chain 1	BindingDB Target Chain Sequence 2	PDB ID(s) of Target Chain 2	UniProt (SwissProt) Recommended Name of Target Chain 2	UniProt (SwissProt) Entry Name of Target Chain 2	UniProt (SwissProt) Primary ID of Target Chain 2	UniProt (SwissProt) Secondary ID(s) of Target Chain 2	UniProt (SwissProt) Alternative ID(s) of Target Chain 2	UniProt (TrEMBL) Submitted Name of Target Chain 2	UniProt (TrEMBL) Entry Name of Target Chain 2	UniProt (TrEMBL) Primary ID of Target Chain 2	UniProt (TrEMBL) Secondary ID(s) of Target Chain 2	UniProt (TrEMBL) Alternative ID(s) of Target Chain 2	BindingDB Target Chain Sequence 3	PDB ID(s) of Target Chain 3	UniProt (SwissProt) Recommended Name of Target Chain 3	UniProt (SwissProt) Entry Name of Target Chain 3	UniProt (SwissProt) Primary ID of Target Chain 3	UniProt (SwissProt) Secondary ID(s) of Target Chain 3	UniProt (SwissProt) Alternative ID(s) of Target Chain 3	UniProt (TrEMBL) Submitted Name of Target Chain 3	UniProt (TrEMBL) Entry Name of Target Chain 3	UniProt (TrEMBL) Primary ID of Target Chain 3	UniProt (TrEMBL) Secondary ID(s) of Target Chain 3	UniProt (TrEMBL) Alternative ID(s) of Target Chain 3	BindingDB Target Chain Sequence 4	PDB ID(s) of Target Chain 4	UniProt (SwissProt) Recommended Name of Target Chain 4	UniProt (SwissProt) Entry Name of Target Chain 4	UniProt (SwissProt) Primary ID of Target Chain 4	UniProt (SwissProt) Secondary ID(s) of Target Chain 4	UniProt (SwissProt) Alternative ID(s) of Target Chain 4	UniProt (TrEMBL) Submitted Name of Target Chain 4	UniProt (TrEMBL) Entry Name of Target Chain 4	UniProt (TrEMBL) Primary ID of Target Chain 4	UniProt (TrEMBL) Secondary ID(s) of Target Chain 4	UniProt (TrEMBL) Alternative ID(s) of Target Chain 4	BindingDB Target Chain Sequence 5	PDB ID(s) of Target Chain 5	UniProt (SwissProt) Recommended Name of Target Chain 5	UniProt (SwissProt) Entry Name of Target Chain 5	UniProt (SwissProt) Primary ID of Target Chain 5	UniProt (SwissProt) Secondary ID(s) of Target Chain 5	UniProt (SwissProt) Alternative ID(s) of Target Chain 5	UniProt (TrEMBL) Submitted Name of Target Chain 5	UniProt (TrEMBL) Entry Name of Target Chain 5	UniProt (TrEMBL) Primary ID of Target Chain 5	UniProt (TrEMBL) Secondary ID(s) of Target Chain 5	UniProt (TrEMBL) Alternative ID(s) of Target Chain 5	BindingDB Target Chain Sequence 6	PDB ID(s) of Target Chain 6	UniProt (SwissProt) Recommended Name of Target Chain 6	UniProt (SwissProt) Entry Name of Target Chain 6	UniProt (SwissProt) Primary ID of Target Chain 6	UniProt (SwissProt) Secondary ID(s) of Target Chain 6	UniProt (SwissProt) Alternative ID(s) of Target Chain 6	UniProt (TrEMBL) Submitted Name of Target Chain 6	UniProt (TrEMBL) Entry Name of Target Chain 6	UniProt (TrEMBL) Primary ID of Target Chain 6	UniProt (TrEMBL) Secondary ID(s) of Target Chain 6	UniProt (TrEMBL) Alternative ID(s) of Target Chain 6	BindingDB Target Chain Sequence 7	PDB ID(s) of Target Chain 7	UniProt (SwissProt) Recommended Name of Target Chain 7	UniProt (SwissProt) Entry Name of Target Chain 7	UniProt (SwissProt) Primary ID of Target Chain 7	UniProt (SwissProt) Secondary ID(s) of Target Chain 7	UniProt (SwissProt) Alternative ID(s) of Target Chain 7	UniProt (TrEMBL) Submitted Name of Target Chain 7	UniProt (TrEMBL) Entry Name of Target Chain 7	UniProt (TrEMBL) Primary ID of Target Chain 7	UniProt (TrEMBL) Secondary ID(s) of Target Chain 7	UniProt (TrEMBL) Alternative ID(s) of Target Chain 7	BindingDB Target Chain Sequence 8	PDB ID(s) of Target Chain 8	UniProt (SwissProt) Recommended Name of Target Chain 8	UniProt (SwissProt) Entry Name of Target Chain 8	UniProt (SwissProt) Primary ID of Target Chain 8	UniProt (SwissProt) Secondary ID(s) of Target Chain 8	UniProt (SwissProt) Alternative ID(s) of Target Chain 8	UniProt (TrEMBL) Submitted Name of Target Chain 8	UniProt (TrEMBL) Entry Name of Target Chain 8	UniProt (TrEMBL) Primary ID of Target Chain 8	UniProt (TrEMBL) Secondary ID(s) of Target Chain 8	UniProt (TrEMBL) Alternative ID(s) of Target Chain 8	BindingDB Target Chain Sequence 9	PDB ID(s) of Target Chain 9	UniProt (SwissProt) Recommended Name of Target Chain 9	UniProt (SwissProt) Entry Name of Target Chain 9	UniProt (SwissProt) Primary ID of Target Chain 9	UniProt (SwissProt) Secondary ID(s) of Target Chain 9	UniProt (SwissProt) Alternative ID(s) of Target Chain 9	UniProt (TrEMBL) Submitted Name of Target Chain 9	UniProt (TrEMBL) Entry Name of Target Chain 9	UniProt (TrEMBL) Primary ID of Target Chain 9	UniProt (TrEMBL) Secondary ID(s) of Target Chain 9	UniProt (TrEMBL) Alternative ID(s) of Target Chain 9	BindingDB Target Chain Sequence 10	PDB ID(s) of Target Chain 10	UniProt (SwissProt) Recommended Name of Target Chain 10	UniProt (SwissProt) Entry Name of Target Chain 10	UniProt (SwissProt) Primary ID of Target Chain 10	UniProt (SwissProt) Secondary ID(s) of Target Chain 10	UniProt (SwissProt) Alternative ID(s) of Target Chain 10	UniProt (TrEMBL) Submitted Name of Target Chain 10	UniProt (TrEMBL) Entry Name of Target Chain 10	UniProt (TrEMBL) Primary ID of Target Chain 10	UniProt (TrEMBL) Secondary ID(s) of Target Chain 10	UniProt (TrEMBL) Alternative ID(s) of Target Chain 10	BindingDB Target Chain Sequence 11	PDB ID(s) of Target Chain 11	UniProt (SwissProt) Recommended Name of Target Chain 11	UniProt (SwissProt) Entry Name of Target Chain 11	UniProt (SwissProt) Primary ID of Target Chain 11	UniProt (SwissProt) Secondary ID(s) of Target Chain 11	UniProt (SwissProt) Alternative ID(s) of Target Chain 11	UniProt (TrEMBL) Submitted Name of Target Chain 11	UniProt (TrEMBL) Entry Name of Target Chain 11	UniProt (TrEMBL) Primary ID of Target Chain 11	UniProt (TrEMBL) Secondary ID(s) of Target Chain 11	UniProt (TrEMBL) Alternative ID(s) of Target Chain 11	BindingDB Target Chain Sequence 12	PDB ID(s) of Target Chain 12	UniProt (SwissProt) Recommended Name of Target Chain 12	UniProt (SwissProt) Entry Name of Target Chain 12	UniProt (SwissProt) Primary ID of Target Chain 12	UniProt (SwissProt) Secondary ID(s) of Target Chain 12	UniProt (SwissProt) Alternative ID(s) of Target Chain 12	UniProt (TrEMBL) Submitted Name of Target Chain 12	UniProt (TrEMBL) Entry Name of Target Chain 12	UniProt (TrEMBL) Primary ID of Target Chain 12	UniProt (TrEMBL) Secondary ID(s) of Target Chain 12	UniProt (TrEMBL) Alternative ID(s) of Target Chain 12	BindingDB Target Chain Sequence 13	PDB ID(s) of Target Chain 13	UniProt (SwissProt) Recommended Name of Target Chain 13	UniProt (SwissProt) Entry Name of Target Chain 13	UniProt (SwissProt) Primary ID of Target Chain 13	UniProt (SwissProt) Secondary ID(s) of Target Chain 13	UniProt (SwissProt) Alternative ID(s) of Target Chain 13	UniProt (TrEMBL) Submitted Name of Target Chain 13	UniProt (TrEMBL) Entry Name of Target Chain 13	UniProt (TrEMBL) Primary ID of Target Chain 13	UniProt (TrEMBL) Secondary ID(s) of Target Chain 13	UniProt (TrEMBL) Alternative ID(s) of Target Chain 13	BindingDB Target Chain Sequence 14	PDB ID(s) of Target Chain 14	UniProt (SwissProt) Recommended Name of Target Chain 14	UniProt (SwissProt) Entry Name of Target Chain 14	UniProt (SwissProt) Primary ID of Target Chain 14	UniProt (SwissProt) Secondary ID(s) of Target Chain 14	UniProt (SwissProt) Alternative ID(s) of Target Chain 14	UniProt (TrEMBL) Submitted Name of Target Chain 14	UniProt (TrEMBL) Entry Name of Target Chain 14	UniProt (TrEMBL) Primary ID of Target Chain 14	UniProt (TrEMBL) Secondary ID(s) of Target Chain 14	UniProt (TrEMBL) Alternative ID(s) of Target Chain 14	BindingDB Target Chain Sequence 15	PDB ID(s) of Target Chain 15	UniProt (SwissProt) Recommended Name of Target Chain 15	UniProt (SwissProt) Entry Name of Target Chain 15	UniProt (SwissProt) Primary ID of Target Chain 15	UniProt (SwissProt) Secondary ID(s) of Target Chain 15	UniProt (SwissProt) Alternative ID(s) of Target Chain 15	UniProt (TrEMBL) Submitted Name of Target Chain 15	UniProt (TrEMBL) Entry Name of Target Chain 15	UniProt (TrEMBL) Primary ID of Target Chain 15	UniProt (TrEMBL) Secondary ID(s) of Target Chain 15	UniProt (TrEMBL) Alternative ID(s) of Target Chain 15	BindingDB Target Chain Sequence 16	PDB ID(s) of Target Chain 16	UniProt (SwissProt) Recommended Name of Target Chain 16	UniProt (SwissProt) Entry Name of Target Chain 16	UniProt (SwissProt) Primary ID of Target Chain 16	UniProt (SwissProt) Secondary ID(s) of Target Chain 16	UniProt (SwissProt) Alternative ID(s) of Target Chain 16	UniProt (TrEMBL) Submitted Name of Target Chain 16	UniProt (TrEMBL) Entry Name of Target Chain 16	UniProt (TrEMBL) Primary ID of Target Chain 16	UniProt (TrEMBL) Secondary ID(s) of Target Chain 16	UniProt (TrEMBL) Alternative ID(s) of Target Chain 16	BindingDB Target Chain Sequence 17	PDB ID(s) of Target Chain 17	UniProt (SwissProt) Recommended Name of Target Chain 17	UniProt (SwissProt) Entry Name of Target Chain 17	UniProt (SwissProt) Primary ID of Target Chain 17	UniProt (SwissProt) Secondary ID(s) of Target Chain 17	UniProt (SwissProt) Alternative ID(s) of Target Chain 17	UniProt (TrEMBL) Submitted Name of Target Chain 17	UniProt (TrEMBL) Entry Name of Target Chain 17	UniProt (TrEMBL) Primary ID of Target Chain 17	UniProt (TrEMBL) Secondary ID(s) of Target Chain 17	UniProt (TrEMBL) Alternative ID(s) of Target Chain 17	BindingDB Target Chain Sequence 18	PDB ID(s) of Target Chain 18	UniProt (SwissProt) Recommended Name of Target Chain 18	UniProt (SwissProt) Entry Name of Target Chain 18	UniProt (SwissProt) Primary ID of Target Chain 18	UniProt (SwissProt) Secondary ID(s) of Target Chain 18	UniProt (SwissProt) Alternative ID(s) of Target Chain 18	UniProt (TrEMBL) Submitted Name of Target Chain 18	UniProt (TrEMBL) Entry Name of Target Chain 18	UniProt (TrEMBL) Primary ID of Target Chain 18	UniProt (TrEMBL) Secondary ID(s) of Target Chain 18	UniProt (TrEMBL) Alternative ID(s) of Target Chain 18	BindingDB Target Chain Sequence 19	PDB ID(s) of Target Chain 19	UniProt (SwissProt) Recommended Name of Target Chain 19	UniProt (SwissProt) Entry Name of Target Chain 19	UniProt (SwissProt) Primary ID of Target Chain 19	UniProt (SwissProt) Secondary ID(s) of Target Chain 19	UniProt (SwissProt) Alternative ID(s) of Target Chain 19	UniProt (TrEMBL) Submitted Name of Target Chain 19	UniProt (TrEMBL) Entry Name of Target Chain 19	UniProt (TrEMBL) Primary ID of Target Chain 19	UniProt (TrEMBL) Secondary ID(s) of Target Chain 19	UniProt (TrEMBL) Alternative ID(s) of Target Chain 19	BindingDB Target Chain Sequence 20	PDB ID(s) of Target Chain 20	UniProt (SwissProt) Recommended Name of Target Chain 20	UniProt (SwissProt) Entry Name of Target Chain 20	UniProt (SwissProt) Primary ID of Target Chain 20	UniProt (SwissProt) Secondary ID(s) of Target Chain 20	UniProt (SwissProt) Alternative ID(s) of Target Chain 20	UniProt (TrEMBL) Submitted Name of Target Chain 20	UniProt (TrEMBL) Entry Name of Target Chain 20	UniProt (TrEMBL) Primary ID of Target Chain 20	UniProt (TrEMBL) Secondary ID(s) of Target Chain 20	UniProt (TrEMBL) Alternative ID(s) of Target Chain 20	BindingDB Target Chain Sequence 21	PDB ID(s) of Target Chain 21	UniProt (SwissProt) Recommended Name of Target Chain 21	UniProt (SwissProt) Entry Name of Target Chain 21	UniProt (SwissProt) Primary ID of Target Chain 21	UniProt (SwissProt) Secondary ID(s) of Target Chain 21	UniProt (SwissProt) Alternative ID(s) of Target Chain 21	UniProt (TrEMBL) Submitted Name of Target Chain 21	UniProt (TrEMBL) Entry Name of Target Chain 21	UniProt (TrEMBL) Primary ID of Target Chain 21	UniProt (TrEMBL) Secondary ID(s) of Target Chain 21	UniProt (TrEMBL) Alternative ID(s) of Target Chain 21	BindingDB Target Chain Sequence 22	PDB ID(s) of Target Chain 22	UniProt (SwissProt) Recommended Name of Target Chain 22	UniProt (SwissProt) Entry Name of Target Chain 22	UniProt (SwissProt) Primary ID of Target Chain 22	UniProt (SwissProt) Secondary ID(s) of Target Chain 22	UniProt (SwissProt) Alternative ID(s) of Target Chain 22	UniProt (TrEMBL) Submitted Name of Target Chain 22	UniProt (TrEMBL) Entry Name of Target Chain 22	UniProt (TrEMBL) Primary ID of Target Chain 22	UniProt (TrEMBL) Secondary ID(s) of Target Chain 22	UniProt (TrEMBL) Alternative ID(s) of Target Chain 22	BindingDB Target Chain Sequence 23	PDB ID(s) of Target Chain 23	UniProt (SwissProt) Recommended Name of Target Chain 23	UniProt (SwissProt) Entry Name of Target Chain 23	UniProt (SwissProt) Primary ID of Target Chain 23	UniProt (SwissProt) Secondary ID(s) of Target Chain 23	UniProt (SwissProt) Alternative ID(s) of Target Chain 23	UniProt (TrEMBL) Submitted Name of Target Chain 23	UniProt (TrEMBL) Entry Name of Target Chain 23	UniProt (TrEMBL) Primary ID of Target Chain 23	UniProt (TrEMBL) Secondary ID(s) of Target Chain 23	UniProt (TrEMBL) Alternative ID(s) of Target Chain 23	BindingDB Target Chain Sequence 24	PDB ID(s) of Target Chain 24	UniProt (SwissProt) Recommended Name of Target Chain 24	UniProt (SwissProt) Entry Name of Target Chain 24	UniProt (SwissProt) Primary ID of Target Chain 24	UniProt (SwissProt) Secondary ID(s) of Target Chain 24	UniProt (SwissProt) Alternative ID(s) of Target Chain 24	UniProt (TrEMBL) Submitted Name of Target Chain 24	UniProt (TrEMBL) Entry Name of Target Chain 24	UniProt (TrEMBL) Primary ID of Target Chain 24	UniProt (TrEMBL) Secondary ID(s) of Target Chain 24	UniProt (TrEMBL) Alternative ID(s) of Target Chain 24	BindingDB Target Chain Sequence 25	PDB ID(s) of Target Chain 25	UniProt (SwissProt) Recommended Name of Target Chain 25	UniProt (SwissProt) Entry Name of Target Chain 25	UniProt (SwissProt) Primary ID of Target Chain 25	UniProt (SwissProt) Secondary ID(s) of Target Chain 25	UniProt (SwissProt) Alternative ID(s) of Target Chain 25	UniProt (TrEMBL) Submitted Name of Target Chain 25	UniProt (TrEMBL) Entry Name of Target Chain 25	UniProt (TrEMBL) Primary ID of Target Chain 25	UniProt (TrEMBL) Secondary ID(s) of Target Chain 25	UniProt (TrEMBL) Alternative ID(s) of Target Chain 25	BindingDB Target Chain Sequence 26	PDB ID(s) of Target Chain 26	UniProt (SwissProt) Recommended Name of Target Chain 26	UniProt (SwissProt) Entry Name of Target Chain 26	UniProt (SwissProt) Primary ID of Target Chain 26	UniProt (SwissProt) Secondary ID(s) of Target Chain 26	UniProt (SwissProt) Alternative ID(s) of Target Chain 26	UniProt (TrEMBL) Submitted Name of Target Chain 26	UniProt (TrEMBL) Entry Name of Target Chain 26	UniProt (TrEMBL) Primary ID of Target Chain 26	UniProt (TrEMBL) Secondary ID(s) of Target Chain 26	UniProt (TrEMBL) Alternative ID(s) of Target Chain 26	BindingDB Target Chain Sequence 27	PDB ID(s) of Target Chain 27	UniProt (SwissProt) Recommended Name of Target Chain 27	UniProt (SwissProt) Entry Name of Target Chain 27	UniProt (SwissProt) Primary ID of Target Chain 27	UniProt (SwissProt) Secondary ID(s) of Target Chain 27	UniProt (SwissProt) Alternative ID(s) of Target Chain 27	UniProt (TrEMBL) Submitted Name of Target Chain 27	UniProt (TrEMBL) Entry Name of Target Chain 27	UniProt (TrEMBL) Primary ID of Target Chain 27	UniProt (TrEMBL) Secondary ID(s) of Target Chain 27	UniProt (TrEMBL) Alternative ID(s) of Target Chain 27	BindingDB Target Chain Sequence 28	PDB ID(s) of Target Chain 28	UniProt (SwissProt) Recommended Name of Target Chain 28	UniProt (SwissProt) Entry Name of Target Chain 28	UniProt (SwissProt) Primary ID of Target Chain 28	UniProt (SwissProt) Secondary ID(s) of Target Chain 28	UniProt (SwissProt) Alternative ID(s) of Target Chain 28	UniProt (TrEMBL) Submitted Name of Target Chain 28	UniProt (TrEMBL) Entry Name of Target Chain 28	UniProt (TrEMBL) Primary ID of Target Chain 28	UniProt (TrEMBL) Secondary ID(s) of Target Chain 28	UniProt (TrEMBL) Alternative ID(s) of Target Chain 28	BindingDB Target Chain Sequence 29	PDB ID(s) of Target Chain 29	UniProt (SwissProt) Recommended Name of Target Chain 29	UniProt (SwissProt) Entry Name of Target Chain 29	UniProt (SwissProt) Primary ID of Target Chain 29	UniProt (SwissProt) Secondary ID(s) of Target Chain 29	UniProt (SwissProt) Alternative ID(s) of Target Chain 29	UniProt (TrEMBL) Submitted Name of Target Chain 29	UniProt (TrEMBL) Entry Name of Target Chain 29	UniProt (TrEMBL) Primary ID of Target Chain 29	UniProt (TrEMBL) Secondary ID(s) of Target Chain 29	UniProt (TrEMBL) Alternative ID(s) of Target Chain 29	BindingDB Target Chain Sequence 30	PDB ID(s) of Target Chain 30	UniProt (SwissProt) Recommended Name of Target Chain 30	UniProt (SwissProt) Entry Name of Target Chain 30	UniProt (SwissProt) Primary ID of Target Chain 30	UniProt (SwissProt) Secondary ID(s) of Target Chain 30	UniProt (SwissProt) Alternative ID(s) of Target Chain 30	UniProt (TrEMBL) Submitted Name of Target Chain 30	UniProt (TrEMBL) Entry Name of Target Chain 30	UniProt (TrEMBL) Primary ID of Target Chain 30	UniProt (TrEMBL) Secondary ID(s) of Target Chain 30	UniProt (TrEMBL) Alternative ID(s) of Target Chain 30	BindingDB Target Chain Sequence 31	PDB ID(s) of Target Chain 31	UniProt (SwissProt) Recommended Name of Target Chain 31	UniProt (SwissProt) Entry Name of Target Chain 31	UniProt (SwissProt) Primary ID of Target Chain 31	UniProt (SwissProt) Secondary ID(s) of Target Chain 31	UniProt (SwissProt) Alternative ID(s) of Target Chain 31	UniProt (TrEMBL) Submitted Name of Target Chain 31	UniProt (TrEMBL) Entry Name of Target Chain 31	UniProt (TrEMBL) Primary ID of Target Chain 31	UniProt (TrEMBL) Secondary ID(s) of Target Chain 31	UniProt (TrEMBL) Alternative ID(s) of Target Chain 31	BindingDB Target Chain Sequence 32	PDB ID(s) of Target Chain 32	UniProt (SwissProt) Recommended Name of Target Chain 32	UniProt (SwissProt) Entry Name of Target Chain 32	UniProt (SwissProt) Primary ID of Target Chain 32	UniProt (SwissProt) Secondary ID(s) of Target Chain 32	UniProt (SwissProt) Alternative ID(s) of Target Chain 32	UniProt (TrEMBL) Submitted Name of Target Chain 32	UniProt (TrEMBL) Entry Name of Target Chain 32	UniProt (TrEMBL) Primary ID of Target Chain 32	UniProt (TrEMBL) Secondary ID(s) of Target Chain 32	UniProt (TrEMBL) Alternative ID(s) of Target Chain 32	BindingDB Target Chain Sequence 33	PDB ID(s) of Target Chain 33	UniProt (SwissProt) Recommended Name of Target Chain 33	UniProt (SwissProt) Entry Name of Target Chain 33	UniProt (SwissProt) Primary ID of Target Chain 33	UniProt (SwissProt) Secondary ID(s) of Target Chain 33	UniProt (SwissProt) Alternative ID(s) of Target Chain 33	UniProt (TrEMBL) Submitted Name of Target Chain 33	UniProt (TrEMBL) Entry Name of Target Chain 33	UniProt (TrEMBL) Primary ID of Target Chain 33	UniProt (TrEMBL) Secondary ID(s) of Target Chain 33	UniProt (TrEMBL) Alternative ID(s) of Target Chain 33	BindingDB Target Chain Sequence 34	PDB ID(s) of Target Chain 34	UniProt (SwissProt) Recommended Name of Target Chain 34	UniProt (SwissProt) Entry Name of Target Chain 34	UniProt (SwissProt) Primary ID of Target Chain 34	UniProt (SwissProt) Secondary ID(s) of Target Chain 34	UniProt (SwissProt) Alternative ID(s) of Target Chain 34	UniProt (TrEMBL) Submitted Name of Target Chain 34	UniProt (TrEMBL) Entry Name of Target Chain 34	UniProt (TrEMBL) Primary ID of Target Chain 34	UniProt (TrEMBL) Secondary ID(s) of Target Chain 34	UniProt (TrEMBL) Alternative ID(s) of Target Chain 34	BindingDB Target Chain Sequence 35	PDB ID(s) of Target Chain 35	UniProt (SwissProt) Recommended Name of Target Chain 35	UniProt (SwissProt) Entry Name of Target Chain 35	UniProt (SwissProt) Primary ID of Target Chain 35	UniProt (SwissProt) Secondary ID(s) of Target Chain 35	UniProt (SwissProt) Alternative ID(s) of Target Chain 35	UniProt (TrEMBL) Submitted Name of Target Chain 35	UniProt (TrEMBL) Entry Name of Target Chain 35	UniProt (TrEMBL) Primary ID of Target Chain 35	UniProt (TrEMBL) Secondary ID(s) of Target Chain 35	UniProt (TrEMBL) Alternative ID(s) of Target Chain 35	BindingDB Target Chain Sequence 36	PDB ID(s) of Target Chain 36	UniProt (SwissProt) Recommended Name of Target Chain 36	UniProt (SwissProt) Entry Name of Target Chain 36	UniProt (SwissProt) Primary ID of Target Chain 36	UniProt (SwissProt) Secondary ID(s) of Target Chain 36	UniProt (SwissProt) Alternative ID(s) of Target Chain 36	UniProt (TrEMBL) Submitted Name of Target Chain 36	UniProt (TrEMBL) Entry Name of Target Chain 36	UniProt (TrEMBL) Primary ID of Target Chain 36	UniProt (TrEMBL) Secondary ID(s) of Target Chain 36	UniProt (TrEMBL) Alternative ID(s) of Target Chain 36	BindingDB Target Chain Sequence 37	PDB ID(s) of Target Chain 37	UniProt (SwissProt) Recommended Name of Target Chain 37	UniProt (SwissProt) Entry Name of Target Chain 37	UniProt (SwissProt) Primary ID of Target Chain 37	UniProt (SwissProt) Secondary ID(s) of Target Chain 37	UniProt (SwissProt) Alternative ID(s) of Target Chain 37	UniProt (TrEMBL) Submitted Name of Target Chain 37	UniProt (TrEMBL) Entry Name of Target Chain 37	UniProt (TrEMBL) Primary ID of Target Chain 37	UniProt (TrEMBL) Secondary ID(s) of Target Chain 37	UniProt (TrEMBL) Alternative ID(s) of Target Chain 37	BindingDB Target Chain Sequence 38	PDB ID(s) of Target Chain 38	UniProt (SwissProt) Recommended Name of Target Chain 38	UniProt (SwissProt) Entry Name of Target Chain 38	UniProt (SwissProt) Primary ID of Target Chain 38	UniProt (SwissProt) Secondary ID(s) of Target Chain 38	UniProt (SwissProt) Alternative ID(s) of Target Chain 38	UniProt (TrEMBL) Submitted Name of Target Chain 38	UniProt (TrEMBL) Entry Name of Target Chain 38	UniProt (TrEMBL) Primary ID of Target Chain 38	UniProt (TrEMBL) Secondary ID(s) of Target Chain 38	UniProt (TrEMBL) Alternative ID(s) of Target Chain 38	BindingDB Target Chain Sequence 39	PDB ID(s) of Target Chain 39	UniProt (SwissProt) Recommended Name of Target Chain 39	UniProt (SwissProt) Entry Name of Target Chain 39	UniProt (SwissProt) Primary ID of Target Chain 39	UniProt (SwissProt) Secondary ID(s) of Target Chain 39	UniProt (SwissProt) Alternative ID(s) of Target Chain 39	UniProt (TrEMBL) Submitted Name of Target Chain 39	UniProt (TrEMBL) Entry Name of Target Chain 39	UniProt (TrEMBL) Primary ID of Target Chain 39	UniProt (TrEMBL) Secondary ID(s) of Target Chain 39	UniProt (TrEMBL) Alternative ID(s) of Target Chain 39	BindingDB Target Chain Sequence 40	PDB ID(s) of Target Chain 40	UniProt (SwissProt) Recommended Name of Target Chain 40	UniProt (SwissProt) Entry Name of Target Chain 40	UniProt (SwissProt) Primary ID of Target Chain 40	UniProt (SwissProt) Secondary ID(s) of Target Chain 40	UniProt (SwissProt) Alternative ID(s) of Target Chain 40	UniProt (TrEMBL) Submitted Name of Target Chain 40	UniProt (TrEMBL) Entry Name of Target Chain 40	UniProt (TrEMBL) Primary ID of Target Chain 40	UniProt (TrEMBL) Secondary ID(s) of Target Chain 40	UniProt (TrEMBL) Alternative ID(s) of Target Chain 40	BindingDB Target Chain Sequence 41	PDB ID(s) of Target Chain 41	UniProt (SwissProt) Recommended Name of Target Chain 41	UniProt (SwissProt) Entry Name of Target Chain 41	UniProt (SwissProt) Primary ID of Target Chain 41	UniProt (SwissProt) Secondary ID(s) of Target Chain 41	UniProt (SwissProt) Alternative ID(s) of Target Chain 41	UniProt (TrEMBL) Submitted Name of Target Chain 41	UniProt (TrEMBL) Entry Name of Target Chain 41	UniProt (TrEMBL) Primary ID of Target Chain 41	UniProt (TrEMBL) Secondary ID(s) of Target Chain 41	UniProt (TrEMBL) Alternative ID(s) of Target Chain 41	BindingDB Target Chain Sequence 42	PDB ID(s) of Target Chain 42	UniProt (SwissProt) Recommended Name of Target Chain 42	UniProt (SwissProt) Entry Name of Target Chain 42	UniProt (SwissProt) Primary ID of Target Chain 42	UniProt (SwissProt) Secondary ID(s) of Target Chain 42	UniProt (SwissProt) Alternative ID(s) of Target Chain 42	UniProt (TrEMBL) Submitted Name of Target Chain 42	UniProt (TrEMBL) Entry Name of Target Chain 42	UniProt (TrEMBL) Primary ID of Target Chain 42	UniProt (TrEMBL) Secondary ID(s) of Target Chain 42	UniProt (TrEMBL) Alternative ID(s) of Target Chain 42	BindingDB Target Chain Sequence 43	PDB ID(s) of Target Chain 43	UniProt (SwissProt) Recommended Name of Target Chain 43	UniProt (SwissProt) Entry Name of Target Chain 43	UniProt (SwissProt) Primary ID of Target Chain 43	UniProt (SwissProt) Secondary ID(s) of Target Chain 43	UniProt (SwissProt) Alternative ID(s) of Target Chain 43	UniProt (TrEMBL) Submitted Name of Target Chain 43	UniProt (TrEMBL) Entry Name of Target Chain 43	UniProt (TrEMBL) Primary ID of Target Chain 43	UniProt (TrEMBL) Secondary ID(s) of Target Chain 43	UniProt (TrEMBL) Alternative ID(s) of Target Chain 43	BindingDB Target Chain Sequence 44	PDB ID(s) of Target Chain 44	UniProt (SwissProt) Recommended Name of Target Chain 44	UniProt (SwissProt) Entry Name of Target Chain 44	UniProt (SwissProt) Primary ID of Target Chain 44	UniProt (SwissProt) Secondary ID(s) of Target Chain 44	UniProt (SwissProt) Alternative ID(s) of Target Chain 44	UniProt (TrEMBL) Submitted Name of Target Chain 44	UniProt (TrEMBL) Entry Name of Target Chain 44	UniProt (TrEMBL) Primary ID of Target Chain 44	UniProt (TrEMBL) Secondary ID(s) of Target Chain 44	UniProt (TrEMBL) Alternative ID(s) of Target Chain 44	BindingDB Target Chain Sequence 45	PDB ID(s) of Target Chain 45	UniProt (SwissProt) Recommended Name of Target Chain 45	UniProt (SwissProt) Entry Name of Target Chain 45	UniProt (SwissProt) Primary ID of Target Chain 45	UniProt (SwissProt) Secondary ID(s) of Target Chain 45	UniProt (SwissProt) Alternative ID(s) of Target Chain 45	UniProt (TrEMBL) Submitted Name of Target Chain 45	UniProt (TrEMBL) Entry Name of Target Chain 45	UniProt (TrEMBL) Primary ID of Target Chain 45	UniProt (TrEMBL) Secondary ID(s) of Target Chain 45	UniProt (TrEMBL) Alternative ID(s) of Target Chain 45	BindingDB Target Chain Sequence 46	PDB ID(s) of Target Chain 46	UniProt (SwissProt) Recommended Name of Target Chain 46	UniProt (SwissProt) Entry Name of Target Chain 46	UniProt (SwissProt) Primary ID of Target Chain 46	UniProt (SwissProt) Secondary ID(s) of Target Chain 46	UniProt (SwissProt) Alternative ID(s) of Target Chain 46	UniProt (TrEMBL) Submitted Name of Target Chain 46	UniProt (TrEMBL) Entry Name of Target Chain 46	UniProt (TrEMBL) Primary ID of Target Chain 46	UniProt (TrEMBL) Secondary ID(s) of Target Chain 46	UniProt (TrEMBL) Alternative ID(s) of Target Chain 46	BindingDB Target Chain Sequence 47	PDB ID(s) of Target Chain 47	UniProt (SwissProt) Recommended Name of Target Chain 47	UniProt (SwissProt) Entry Name of Target Chain 47	UniProt (SwissProt) Primary ID of Target Chain 47	UniProt (SwissProt) Secondary ID(s) of Target Chain 47	UniProt (SwissProt) Alternative ID(s) of Target Chain 47	UniProt (TrEMBL) Submitted Name of Target Chain 47	UniProt (TrEMBL) Entry Name of Target Chain 47	UniProt (TrEMBL) Primary ID of Target Chain 47	UniProt (TrEMBL) Secondary ID(s) of Target Chain 47	UniProt (TrEMBL) Alternative ID(s) of Target Chain 47	BindingDB Target Chain Sequence 48	PDB ID(s) of Target Chain 48	UniProt (SwissProt) Recommended Name of Target Chain 48	UniProt (SwissProt) Entry Name of Target Chain 48	UniProt (SwissProt) Primary ID of Target Chain 48	UniProt (SwissProt) Secondary ID(s) of Target Chain 48	UniProt (SwissProt) Alternative ID(s) of Target Chain 48	UniProt (TrEMBL) Submitted Name of Target Chain 48	UniProt (TrEMBL) Entry Name of Target Chain 48	UniProt (TrEMBL) Primary ID of Target Chain 48	UniProt (TrEMBL) Secondary ID(s) of Target Chain 48	UniProt (TrEMBL) Alternative ID(s) of Target Chain 48	BindingDB Target Chain Sequence 49	PDB ID(s) of Target Chain 49	UniProt (SwissProt) Recommended Name of Target Chain 49	UniProt (SwissProt) Entry Name of Target Chain 49	UniProt (SwissProt) Primary ID of Target Chain 49	UniProt (SwissProt) Secondary ID(s) of Target Chain 49	UniProt (SwissProt) Alternative ID(s) of Target Chain 49	UniProt (TrEMBL) Submitted Name of Target Chain 49	UniProt (TrEMBL) Entry Name of Target Chain 49	UniProt (TrEMBL) Primary ID of Target Chain 49	UniProt (TrEMBL) Secondary ID(s) of Target Chain 49	UniProt (TrEMBL) Alternative ID(s) of Target Chain 49	BindingDB Target Chain Sequence 50	PDB ID(s) of Target Chain 50	UniProt (SwissProt) Recommended Name of Target Chain 50	UniProt (SwissProt) Entry Name of Target Chain 50	UniProt (SwissProt) Primary ID of Target Chain 50	UniProt (SwissProt) Secondary ID(s) of Target Chain 50	UniProt (SwissProt) Alternative ID(s) of Target Chain 50	UniProt (TrEMBL) Submitted Name of Target Chain 50	UniProt (TrEMBL) Entry Name of Target Chain 50	UniProt (TrEMBL) Primary ID of Target Chain 50	UniProt (TrEMBL) Secondary ID(s) of Target Chain 50	UniProt (TrEMBL) Alternative ID(s) of Target Chain 50
211633	Nc1cc(Cl)c2c(c1F)[C@]1(CCC2)Cc2nc(OC[C@@]34CCCN3C[C@@H](F)C4)nc(N3CCCOCC3)c2CO1	InChI=1S/C29H36ClF2N5O3/c30-21-12-22(33)25(32)24-19(21)4-1-6-29(24)14-23-20(16-40-29)26(36-7-3-10-38-11-9-36)35-27(34-23)39-17-28-5-2-8-37(28)15-18(31)13-28/h12,18H,1-11,13-17,33H2	BVKBLWHFCAQFOA-UHFFFAOYSA-N	436793	US20260022132, Compound 181b*	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 330							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436793	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436793&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493739	439658422							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211634	Cc1cc(N)c(F)c2c1CCCC21Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc(N3CCCn4nc(C(=O)N(C)C)cc4C3)c2CO1	InChI=1S/C35H44F2N8O3/c1-21-13-26(38)30(37)29-24(21)7-4-9-35(29)16-28-25(19-48-35)31(40-33(39-28)47-20-34-8-5-11-44(34)17-22(36)15-34)43-10-6-12-45-23(18-43)14-27(41-45)32(46)42(2)3/h13-14,22H,4-12,15-20,38H2,1-3H3	AKSQNOMFRXXNMX-UHFFFAOYSA-N	436794	5-(7-amino-8-fluoro-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-5-methyl-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidin]-4'-yl)-N,N-dimethyl-5,6,7,8-tetrahydro-4H-pyrazolo[1,5-a][1,4]diazepine-2-carboxamide ::US20260022132, Compound 501a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 22.0							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436794	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436794&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493954	439658423							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211635	Cc1cc(N)c(F)c2c1CCC[C@]21Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc(N3CCCn4nc(C(=O)N(C)C)cc4C3)c2CO1	InChI=1S/C35H44F2N8O3/c1-21-13-26(38)30(37)29-24(21)7-4-9-35(29)16-28-25(19-48-35)31(40-33(39-28)47-20-34-8-5-11-44(34)17-22(36)15-34)43-10-6-12-45-23(18-43)14-27(41-45)32(46)42(2)3/h13-14,22H,4-12,15-20,38H2,1-3H3	AKSQNOMFRXXNMX-UHFFFAOYSA-N	436795	5-((S)-7-amino-8-fluoro-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-5-methyl-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidin]-4'-yl)-N,N-dimethyl-5,6,7,8-tetrahydro-4H-pyrazolo[1,5-a][1,4]diazepine-2-carboxamide ::US20260022132, Compound 501b	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 23.0							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436795	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436795&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493772	439658424							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211636	Cc1cc(N)c(F)c2c1CCC[C@@]21Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc(N3CCCn4nc(C(=O)N(C)C)cc4C3)c2CO1	InChI=1S/C35H44F2N8O3/c1-21-13-26(38)30(37)29-24(21)7-4-9-35(29)16-28-25(19-48-35)31(40-33(39-28)47-20-34-8-5-11-44(34)17-22(36)15-34)43-10-6-12-45-23(18-43)14-27(41-45)32(46)42(2)3/h13-14,22H,4-12,15-20,38H2,1-3H3	AKSQNOMFRXXNMX-UHFFFAOYSA-N	436796	5-((R)-7-amino-8-fluoro-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-5-methyl-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidin]-4'-yl)-N,N-dimethyl-5,6,7,8-tetrahydro-4H-pyrazolo[1,5-a][1,4]diazepine-2-carboxamide ::US20260022132, Compound 501c	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 6000							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436796	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436796&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493700	439658425							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211637	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCC[C@@H](C#N)CC4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C33H40FN7O2/c1-21-7-10-33(29-24(21)5-6-27(37)25(29)17-36)15-28-26(19-43-33)30(40-11-2-4-22(16-35)8-13-40)39-31(38-28)42-20-32-9-3-12-41(32)18-23(34)14-32/h5-6,21-23H,2-4,7-15,18-20,37H2,1H3	NWVHCBTZYXKQBO-UHFFFAOYSA-N	436797	(1S,4S)-7-amino-4'-((R*)-4-cyanoazepan-1-yl)-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-4-methyl-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidine]-8-carbonitrile ::US20260022132, Compound 502a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 3.30							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436797	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436797&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493686	439658426							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211638	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCC[C@H](C#N)CC4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C33H40FN7O2/c1-21-7-10-33(29-24(21)5-6-27(37)25(29)17-36)15-28-26(19-43-33)30(40-11-2-4-22(16-35)8-13-40)39-31(38-28)42-20-32-9-3-12-41(32)18-23(34)14-32/h5-6,21-23H,2-4,7-15,18-20,37H2,1H3	NWVHCBTZYXKQBO-UHFFFAOYSA-N	436798	(1S,4S)-7-amino-4'-((S*)-4-cyanoazepan-1-yl)-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-4-methyl-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidine]-8-carbonitrile ::US20260022132, Compound 502b	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 3.80							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436798	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436798&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493784	439658427							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211639	N#Cc1c(N)ccc2c1C1(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCCOCC4)c3CO1)C1CC2C1	InChI=1S/C31H37FN6O3/c32-21-13-30(5-1-7-38(30)16-21)18-40-29-35-26-14-31(41-17-24(26)28(36-29)37-6-2-9-39-10-8-37)20-11-19(12-20)22-3-4-25(34)23(15-33)27(22)31/h3-4,19-21H,1-2,5-14,16-18,34H2	UZDBRLGBTAUPGA-UHFFFAOYSA-N	436799	6'-Amino-2-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-4-(1,4-oxazepan-4-yl)-2',3',5,8-tetrahydro-1'H-spiro[pyrano[4,3-d]pyrimidine-7,4'-[1,3]methanonaphthalene]-5'-carbonitrile ::US20260022132, Compound 503a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 2000							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436799	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436799&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134490019	439658428							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211640	N#Cc1c(N)ccc2c1[C@]1(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCCOCC4)c3CO1)C1CC2C1	InChI=1S/C31H37FN6O3/c32-21-13-30(5-1-7-38(30)16-21)18-40-29-35-26-14-31(41-17-24(26)28(36-29)37-6-2-9-39-10-8-37)20-11-19(12-20)22-3-4-25(34)23(15-33)27(22)31/h3-4,19-21H,1-2,5-14,16-18,34H2	UZDBRLGBTAUPGA-UHFFFAOYSA-N	436800	(7S)-6'-Amino-2-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-4-(1,4-oxazepan-4-yl)-2',3',5,8-tetrahydro-1'H-spiro[pyrano[4,3-d]pyrimidine-7,4'-[1,3]methanonaphthalene]-5'-carbonitrile ::US20260022132, Compound 503b	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			>10000							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436800	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436800&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134494024	439658429							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211641	N#Cc1c(N)ccc2c1[C@@]1(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCCOCC4)c3CO1)C1CC2C1	InChI=1S/C31H37FN6O3/c32-21-13-30(5-1-7-38(30)16-21)18-40-29-35-26-14-31(41-17-24(26)28(36-29)37-6-2-9-39-10-8-37)20-11-19(12-20)22-3-4-25(34)23(15-33)27(22)31/h3-4,19-21H,1-2,5-14,16-18,34H2	UZDBRLGBTAUPGA-UHFFFAOYSA-N	436801	(7R)-6'-Amino-2-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-4-(1,4-oxazepan-4-yl)-2',3',5,8-tetrahydro-1'H-spiro[pyrano[4,3-d]pyrimidine-7,4'-[1,3]methanonaphthalene]-5'-carbonitrile ::US20260022132, Compound 503c	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 860							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436801	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436801&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493733	439658430							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211642	CN(C)C(=O)c1cc2n(n1)CCCN(c1nc(OC[C@@]34CCCN3C[C@H](F)C4)nc3c1CO[C@@]1(C3)c3c(ccc(N)c3C#N)C3CC1C3)C2	InChI=1S/C36H42FN9O3/c1-43(2)33(47)29-13-24-18-44(8-4-10-46(24)42-29)32-27-19-49-36(22-11-21(12-22)25-5-6-28(39)26(16-38)31(25)36)15-30(27)40-34(41-32)48-20-35-7-3-9-45(35)17-23(37)14-35/h5-6,13,21-23H,3-4,7-12,14-15,17-20,39H2,1-2H3	ZGIJEKLVPIKVJJ-UHFFFAOYSA-N	436802	5-((7R)-6'-amino-5'-cyano-2-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-2',3',5,8-tetrahydro-1'H-spiro[pyrano[4,3-d]pyrimidine-7,4'-[1,3]methanonaphthalen]-4-yl)-N,N-dimethyl-5,6,7,8-tetrahydro-4H-pyrazolo[1,5-a][1,4]diazepine-2-carboxamide ::US20260022132, Compound 504a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 9.80							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436802	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436802&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134490023	439658431							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211643	CN(C)C(=O)c1cc2n(n1)CCCN(c1nc(OC[C@@]34CCCN3C[C@H](F)C4)nc3c1COC1(C3)c3c(ccc(N)c3C#N)C3CC1C3)C2	InChI=1S/C36H42FN9O3/c1-43(2)33(47)29-13-24-18-44(8-4-10-46(24)42-29)32-27-19-49-36(22-11-21(12-22)25-5-6-28(39)26(16-38)31(25)36)15-30(27)40-34(41-32)48-20-35-7-3-9-45(35)17-23(37)14-35/h5-6,13,21-23H,3-4,7-12,14-15,17-20,39H2,1-2H3	ZGIJEKLVPIKVJJ-UHFFFAOYSA-N	436803	5-(6'-Amino-5'-cyano-2-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-2',3',5,8-tetrahydro-1'H-spiro[pyrano[4,3-d]pyrimidine-7,4'-[1,3]methanonaphthalen]-4-yl)-N,N-dimethyl-5,6,7,8-tetrahydro-4H-pyrazolo[1,5-a][1,4]diazepine-2-carboxamide ::US20260022132, Compound 504b	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 15.0							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436803	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436803&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134490020	439658432							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211644	CN(C)C(=O)c1cc2n(n1)CCCN(c1nc(OC[C@@]34CCCN3C[C@H](F)C4)nc3c1CO[C@]1(C3)c3c(ccc(N)c3C#N)C3CC1C3)C2	InChI=1S/C36H42FN9O3/c1-43(2)33(47)29-13-24-18-44(8-4-10-46(24)42-29)32-27-19-49-36(22-11-21(12-22)25-5-6-28(39)26(16-38)31(25)36)15-30(27)40-34(41-32)48-20-35-7-3-9-45(35)17-23(37)14-35/h5-6,13,21-23H,3-4,7-12,14-15,17-20,39H2,1-2H3	ZGIJEKLVPIKVJJ-UHFFFAOYSA-N	436804	5-((7S)-6'-amino-5'-cyano-2-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-2',3',5,8-tetrahydro-1'H-spiro[pyrano[4,3-d]pyrimidine-7,4'-[1,3]methanonaphthalen]-4-yl)-N,N-dimethyl-5,6,7,8-tetrahydro-4H-pyrazolo[1,5-a][1,4]diazepine-2-carboxamide ::US20260022132, Compound 504c	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 2000							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436804	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436804&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134490021	439658433							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211645	Cc1cc(N)c(C#N)c2c1CCCC21Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc(N3CCCOCC3)c2CO1	InChI=1S/C31H39FN6O3/c1-20-13-25(34)23(16-33)27-22(20)5-2-7-31(27)15-26-24(18-41-31)28(37-8-4-11-39-12-10-37)36-29(35-26)40-19-30-6-3-9-38(30)17-21(32)14-30/h13,21H,2-12,14-15,17-19,34H2,1H3	MDLDHWUSUSXCHD-UHFFFAOYSA-N	436805	7-Amino-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-5-methyl-4'-(1,4-oxazepan-4-yl)-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidine]-8-carbonitrile ::US20260022132, Compound 505a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 230							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436805	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436805&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134490022	439658434							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211646	Cc1cc(N)c(F)c2c1CCCC21Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc(N3CCCOCC3)c2CO1	InChI=1S/C30H39F2N5O3/c1-19-13-23(33)26(32)25-21(19)5-2-7-30(25)15-24-22(17-40-30)27(36-8-4-11-38-12-10-36)35-28(34-24)39-18-29-6-3-9-37(29)16-20(31)14-29/h13,20H,2-12,14-18,33H2,1H3	GKQQFCIKDFXNEX-UHFFFAOYSA-N	436806	8-Fluoro-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-5-methyl-4'-(1,4-oxazepan-4-yl)-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidin]-7-amine ::US20260022132, Compound 506a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 640							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436806	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436806&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493792	439658435							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211647	CN(C)C(=O)c1nn2c(c1Cl)CN(c1nc(OC[C@@]34CCCN3C[C@H](F)C4)nc3c1COC1(CCCc4ccc(N)c(C#N)c41)C3)CCC2	InChI=1S/C35H41ClFN9O3/c1-43(2)32(47)30-29(36)27-18-44(11-5-13-46(27)42-30)31-24-19-49-35(10-3-6-21-7-8-25(39)23(16-38)28(21)35)15-26(24)40-33(41-31)48-20-34-9-4-12-45(34)17-22(37)14-34/h7-8,22H,3-6,9-15,17-20,39H2,1-2H3	UVCFFLFDHUHSQW-UHFFFAOYSA-N	436807	5-(7-Amino-8-cyano-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidin]-4'-yl)-3-chloro-N,N-dimethyl-5,6,7,8-tetrahydro-4H-pyrazolo[1,5-a][1,4]diazepine-2-carboxamide ::US20260022132, Compound 507a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 5.00							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436807	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436807&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493997	439658436							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211648	CN(C)C(=O)c1nn2c(c1Cl)CN(c1nc(OC[C@@]34CCCN3C[C@H](F)C4)nc3c1CO[C@@]1(CCCc4ccc(N)c(C#N)c41)C3)CCC2	InChI=1S/C35H41ClFN9O3/c1-43(2)32(47)30-29(36)27-18-44(11-5-13-46(27)42-30)31-24-19-49-35(10-3-6-21-7-8-25(39)23(16-38)28(21)35)15-26(24)40-33(41-31)48-20-34-9-4-12-45(34)17-22(37)14-34/h7-8,22H,3-6,9-15,17-20,39H2,1-2H3	UVCFFLFDHUHSQW-UHFFFAOYSA-N	436808	5-((S)-7-Amino-8-cyano-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidin]-4'-yl)-3-chloro-N,N-dimethyl-5,6,7,8-tetrahydro-4H-pyrazolo[1,5-a][1,4]diazepine-2-carboxamide ::US20260022132, Compound 507b	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 2.90							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436808	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436808&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493718	439658437							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211649	CN(C)C(=O)c1nn2c(c1Cl)CN(c1nc(OC[C@@]34CCCN3C[C@H](F)C4)nc3c1CO[C@]1(CCCc4ccc(N)c(C#N)c41)C3)CCC2	InChI=1S/C35H41ClFN9O3/c1-43(2)32(47)30-29(36)27-18-44(11-5-13-46(27)42-30)31-24-19-49-35(10-3-6-21-7-8-25(39)23(16-38)28(21)35)15-26(24)40-33(41-31)48-20-34-9-4-12-45(34)17-22(37)14-34/h7-8,22H,3-6,9-15,17-20,39H2,1-2H3	UVCFFLFDHUHSQW-UHFFFAOYSA-N	436809	5-((R)-7-Amino-8-cyano-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidin]-4'-yl)-3-chloro-N,N-dimethyl-5,6,7,8-tetrahydro-4H-pyrazolo[1,5-a][1,4]diazepine-2-carboxamide ::US20260022132, Compound 507c	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 66.0							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436809	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436809&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493699	439658438							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211650	CC1CCC2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCCOCC4)c3CO2)c2c(F)c(N)cc(Cl)c21	InChI=1S/C30H38ClF2N5O3/c1-18-4-6-30(25-24(18)21(31)12-22(34)26(25)33)14-23-20(16-41-30)27(37-7-3-10-39-11-9-37)36-28(35-23)40-17-29-5-2-8-38(29)15-19(32)13-29/h12,18-19H,2-11,13-17,34H2,1H3	ULAWITNEZNGQKF-UHFFFAOYSA-N	436810	5-Chloro-8-fluoro-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-4-methyl-4'-(1,4-oxazepan-4-yl)-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidin]-7-amine ::US20260022132, Compound 508a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 150							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436810	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436810&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493830	439658439							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211651	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCCn5nc(C(=O)N(C)C)c(Cl)c5C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C36H43ClFN9O3/c1-21-8-10-36(29-23(21)6-7-26(40)24(29)16-39)15-27-25(19-50-36)32(42-34(41-27)49-20-35-9-4-12-46(35)17-22(38)14-35)45-11-5-13-47-28(18-45)30(37)31(43-47)33(48)44(2)3/h6-7,21-22H,4-5,8-15,17-20,40H2,1-3H3	SDNSBDOTDDGQBP-UHFFFAOYSA-N	436811	5-((1S,4S)-7-Amino-8-cyano-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-4-methyl-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidin]-4'-yl)-3-chloro-N,N-dimethyl-5,6,7,8-tetrahydro-4H-pyrazolo[1,5-a][1,4]diazepine-2-carboxamide ::US20260022132, Compound 509a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 3.00							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436811	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436811&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493711	439658440							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211652	C[C@H]1CC[C@@]2(Cc3nc(OC[C@@]45CC(F)CN4C[C@H](F)C5)nc(N4CCCn5nc(C(=O)N(C)C)c(Cl)c5C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C36H42ClF2N9O3/c1-20-7-8-36(29-23(20)5-6-26(41)24(29)14-40)13-27-25(18-51-36)32(43-34(42-27)50-19-35-11-21(38)15-47(35)16-22(39)12-35)46-9-4-10-48-28(17-46)30(37)31(44-48)33(49)45(2)3/h5-6,20-22H,4,7-13,15-19,41H2,1-3H3	BCKNLVPNHWXURD-UHFFFAOYSA-N	436812	5-((1R,4S)-7-Amino-8-cyano-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-4-methyl-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidin]-4'-yl)-3-chloro-N,N-dimethyl-5,6,7,8-tetrahydro-4H-pyrazolo[1,5-a][1,4]diazepine-2-carboxamide ::US20260022132, Compound 509b	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 43.0							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436812	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436812&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493762	439658441							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211653	N#C[C@H]1CCCN(c2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc3c2COC2(CCCc4c(Cl)cc(N)c(F)c42)C3)CC1	InChI=1S/C31H37ClF2N6O2/c32-23-12-24(36)27(34)26-21(23)5-1-8-31(26)14-25-22(17-42-31)28(39-9-2-4-19(15-35)6-11-39)38-29(37-25)41-18-30-7-3-10-40(30)16-20(33)13-30/h12,19-20H,1-11,13-14,16-18,36H2	WHLJSIGCNLEYSF-UHFFFAOYSA-N	436813	(4S*)-1-(7-amino-5-chloro-8-fluoro-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidin]-4'-yl)azepane-4-carbonitrile ::US20260022132, Compound 510a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 670							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436813	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436813&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493706	439658442							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211654	N#C[C@@H]1CCCN(c2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc3c2COC2(CCCc4c(Cl)cc(N)c(F)c42)C3)CC1	InChI=1S/C31H37ClF2N6O2/c32-23-12-24(36)27(34)26-21(23)5-1-8-31(26)14-25-22(17-42-31)28(39-9-2-4-19(15-35)6-11-39)38-29(37-25)41-18-30-7-3-10-40(30)16-20(33)13-30/h12,19-20H,1-11,13-14,16-18,36H2	WHLJSIGCNLEYSF-UHFFFAOYSA-N	436814	(R*)-1-(7-amino-5-chloro-8-fluoro-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidin]-4'-yl)azepane-4-carbonitrile ::US20260022132, Compound 510b	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 370							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436814	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436814&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493863	439658443							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211655	N#C[C@H]1CCCN(c2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc3c2CO[C@]2(CCCc4c(Cl)cc(N)c(F)c42)C3)CC1	InChI=1S/C31H37ClF2N6O2/c32-23-12-24(36)27(34)26-21(23)5-1-8-31(26)14-25-22(17-42-31)28(39-9-2-4-19(15-35)6-11-39)38-29(37-25)41-18-30-7-3-10-40(30)16-20(33)13-30/h12,19-20H,1-11,13-14,16-18,36H2	WHLJSIGCNLEYSF-UHFFFAOYSA-N	436815	(S*)-1-((R)-7-amino-5-chloro-8-fluoro-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidin]-4'-yl)azepane-4-carbonitrile ::US20260022132, Compound 510c	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			>10000							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436815	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436815&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493586	439658444							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211656	N#C[C@H]1CCCN(c2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc3c2CO[C@@]2(CCCc4c(Cl)cc(N)c(F)c42)C3)CC1	InChI=1S/C31H37ClF2N6O2/c32-23-12-24(36)27(34)26-21(23)5-1-8-31(26)14-25-22(17-42-31)28(39-9-2-4-19(15-35)6-11-39)38-29(37-25)41-18-30-7-3-10-40(30)16-20(33)13-30/h12,19-20H,1-11,13-14,16-18,36H2	WHLJSIGCNLEYSF-UHFFFAOYSA-N	436816	(S*)-1-((S)-7-amino-5-chloro-8-fluoro-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidin]-4'-yl)azepane-4-carbonitrile ::US20260022132, Compound 510d	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 450							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436816	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436816&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493736	439658445							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211657	N#C[C@@H]1CCCN(c2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc3c2CO[C@]2(CCCc4c(Cl)cc(N)c(F)c42)C3)CC1	InChI=1S/C31H37ClF2N6O2/c32-23-12-24(36)27(34)26-21(23)5-1-8-31(26)14-25-22(17-42-31)28(39-9-2-4-19(15-35)6-11-39)38-29(37-25)41-18-30-7-3-10-40(30)16-20(33)13-30/h12,19-20H,1-11,13-14,16-18,36H2	WHLJSIGCNLEYSF-UHFFFAOYSA-N	436817	(R*)-1-((R)-7-amino-5-chloro-8-fluoro-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidin]-4'-yl)azepane-4-carbonitrile ::US20260022132, Compound 510e	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			>10000							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436817	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436817&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493727	439658446							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211658	N#C[C@@H]1CCCN(c2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc3c2CO[C@@]2(CCCc4c(Cl)cc(N)c(F)c42)C3)CC1	InChI=1S/C31H37ClF2N6O2/c32-23-12-24(36)27(34)26-21(23)5-1-8-31(26)14-25-22(17-42-31)28(39-9-2-4-19(15-35)6-11-39)38-29(37-25)41-18-30-7-3-10-40(30)16-20(33)13-30/h12,19-20H,1-11,13-14,16-18,36H2	WHLJSIGCNLEYSF-UHFFFAOYSA-N	436818	(R*)-1-((S)-7-amino-5-chloro-8-fluoro-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidin]-4'-yl)azepane-4-carbonitrile ::US20260022132, Compound 510f	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 180							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436818	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436818&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493587	439658447							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211659	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCC[C@@H](CC#N)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C33H40FN7O2/c1-21-7-10-33(29-24(21)5-6-27(37)25(29)16-36)15-28-26(19-43-33)30(40-12-2-4-22(17-40)8-11-35)39-31(38-28)42-20-32-9-3-13-41(32)18-23(34)14-32/h5-6,21-23H,2-4,7-10,12-15,17-20,37H2,1H3	VGEIIJXEWCRVBJ-UHFFFAOYSA-N	436819	(1S,4S)-7-Amino-4'-((S)-3-(cyanomethyl)piperidin-1-yl)-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-4-methyl-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidine]-8-carbonitrile ::US20260022132, Compound 511a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			<2.50							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436819	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436819&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134494032	439658448							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211660	N#Cc1c(N)ccc2c1[C@@]1(CC[C@H]2C(F)(F)F)Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc(N3CCCOCC3)c2CO1	InChI=1S/C31H36F4N6O3/c32-19-13-29(6-1-9-41(29)16-19)18-43-28-38-25-14-30(44-17-22(25)27(39-28)40-8-2-11-42-12-10-40)7-5-23(31(33,34)35)20-3-4-24(37)21(15-36)26(20)30/h3-4,19,23H,1-2,5-14,16-18,37H2	HECHKKOQASXFHC-UHFFFAOYSA-N	436820	(1R*,4R)-7-amino-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-4'-(1,4-oxazepan-4-yl)-4-(trifluoromethyl)-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidine]-8-carbonitrile ::US20260022132, Compound 512a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 1800							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436820	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436820&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493869	439658449							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211661	N#Cc1c(N)ccc2c1[C@]1(CC[C@@H]2C(F)(F)F)Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc(N3CCCOCC3)c2CO1	InChI=1S/C31H36F4N6O3/c32-19-13-29(6-1-9-41(29)16-19)18-43-28-38-25-14-30(44-17-22(25)27(39-28)40-8-2-11-42-12-10-40)7-5-23(31(33,34)35)20-3-4-24(37)21(15-36)26(20)30/h3-4,19,23H,1-2,5-14,16-18,37H2	HECHKKOQASXFHC-UHFFFAOYSA-N	436821	(1S*,4S)-7-Amino-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-4'-(1,4-oxazepan-4-yl)-4-(trifluoromethyl)-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidine]-8-carbonitrile ::US20260022132, Compound 512b	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 6.20							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436821	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436821&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493779	439658450							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211662	CN(C)C(=O)c1cc2n(n1)CCCN(c1nc(OC[C@@H]3CCCN3C)nc3c1COC1(CCCc4ccc(N)c(C#N)c41)C3)C2	InChI=1S/C33H41N9O3/c1-39(2)31(43)27-15-23-18-41(13-6-14-42(23)38-27)30-25-20-45-33(11-4-7-21-9-10-26(35)24(17-34)29(21)33)16-28(25)36-32(37-30)44-19-22-8-5-12-40(22)3/h9-10,15,22H,4-8,11-14,16,18-20,35H2,1-3H3	WPYMDJFWMSLJPU-UHFFFAOYSA-N	436822	5-(7-amino-8-cyano-2'-(((S)-1-methylpyrrolidin-2-yl)methoxy)-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidin]-4'-yl)-N,N-dimethyl-5,6,7,8-tetrahydro-4H-pyrazolo[1,5-a][1,4]diazepine-2-carboxamide ::US20260022132, Compound 513a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 12.0							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436822	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436822&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134494029	439658451							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211663	CN1CC[C@@H](COc2nc3c(c(N4CCCn5nc(C(=O)N(C)C)cc5C4)n2)COC2(CCCc4ccc(N)c(C#N)c42)C3)C1	InChI=1S/C33H41N9O3/c1-39(2)31(43)27-14-23-18-41(11-5-12-42(23)38-27)30-25-20-45-33(10-4-6-22-7-8-26(35)24(16-34)29(22)33)15-28(25)36-32(37-30)44-19-21-9-13-40(3)17-21/h7-8,14,21H,4-6,9-13,15,17-20,35H2,1-3H3	OJOXRWJXEKHICJ-UHFFFAOYSA-N	436823	5-(7-Amino-8-cyano-2'-(((R)-1-methylpyrrolidin-3-yl)methoxy)-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidin]-4'-yl)-N,N-dimethyl-5,6,7,8-tetrahydro-4H-pyrazolo[1,5-a][1,4]diazepine-2-carboxamide ::US20260022132, Compound 514a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 22.0							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436823	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436823&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493564	439658452							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211664	CN1CC[C@H](COc2nc3c(c(N4CCCn5nc(C(=O)N(C)C)cc5C4)n2)COC2(CCCc4ccc(N)c(C#N)c42)C3)C1	InChI=1S/C33H41N9O3/c1-39(2)31(43)27-14-23-18-41(11-5-12-42(23)38-27)30-25-20-45-33(10-4-6-22-7-8-26(35)24(16-34)29(22)33)15-28(25)36-32(37-30)44-19-21-9-13-40(3)17-21/h7-8,14,21H,4-6,9-13,15,17-20,35H2,1-3H3	OJOXRWJXEKHICJ-UHFFFAOYSA-N	436824	5-(7-amino-8-cyano-2'-(((S)-1-methylpyrrolidin-3-yl)methoxy)-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidin]-4'-yl)-N,N-dimethyl-5,6,7,8-tetrahydro-4H-pyrazolo[1,5-a][1,4]diazepine-2-carboxamide ::US20260022132, Compound 514b	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 42.0							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436824	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436824&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493839	439658453							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211665	N#CC[C@H]1CN(c2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc3c2CO[C@@]2(CCCc4ccc(N)cc42)C3)CCO1	InChI=1S/C30H37FN6O3/c31-21-14-29(7-2-10-37(29)16-21)19-39-28-34-26-15-30(8-1-3-20-4-5-22(33)13-25(20)30)40-18-24(26)27(35-28)36-11-12-38-23(17-36)6-9-32/h4-5,13,21,23H,1-3,6-8,10-12,14-19,33H2	JYRYSJDOWRZWEH-UHFFFAOYSA-N	436825	2-((S)-4-((S)-7-amino-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidin]-4'-yl)morpholin-2-yl)acetonitrile ::US20260022132, Compound 515a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 460							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436825	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436825&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493849	439658454							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211666	N#Cc1c(N)ccc2c1[C@]1(CCC2)Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc(N3CCOCC(n4cccn4)C3)c2CO1	InChI=1S/C33H39FN8O3/c34-23-14-32(7-2-10-41(32)17-23)21-44-31-38-28-15-33(8-1-4-22-5-6-27(36)25(16-35)29(22)33)45-20-26(28)30(39-31)40-12-13-43-19-24(18-40)42-11-3-9-37-42/h3,5-6,9,11,23-24H,1-2,4,7-8,10,12-15,17-21,36H2	ZVJCZISSZXHAHJ-UHFFFAOYSA-N	436826	(S)-4'-(6-(1H-pyrazol-1-yl)-1,4-oxazepan-4-yl)-7-amino-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidine]-8-carbonitrile ::US20260022132, Compound 516a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 4.00							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436826	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436826&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134494034	439658455							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211667	N#Cc1c(N)ccc2c1[C@]1(CCC2)Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc(N3CCOC[C@H](n4cccn4)C3)c2CO1	InChI=1S/C33H39FN8O3/c34-23-14-32(7-2-10-41(32)17-23)21-44-31-38-28-15-33(8-1-4-22-5-6-27(36)25(16-35)29(22)33)45-20-26(28)30(39-31)40-12-13-43-19-24(18-40)42-11-3-9-37-42/h3,5-6,9,11,23-24H,1-2,4,7-8,10,12-15,17-21,36H2	ZVJCZISSZXHAHJ-UHFFFAOYSA-N	436827	(S)-4'-((R)-6-(1H-pyrazol-1-yl)-1,4-oxazepan-4-yl)-7-amino-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidine]-8-carbonitrile ::US20260022132, Compound 516b	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 580							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436827	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436827&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134494035	439658456							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211668	N#Cc1c(N)ccc2c1[C@]1(CCC2)Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc(N3CCOC[C@@H](n4cccn4)C3)c2CO1	InChI=1S/C33H39FN8O3/c34-23-14-32(7-2-10-41(32)17-23)21-44-31-38-28-15-33(8-1-4-22-5-6-27(36)25(16-35)29(22)33)45-20-26(28)30(39-31)40-12-13-43-19-24(18-40)42-11-3-9-37-42/h3,5-6,9,11,23-24H,1-2,4,7-8,10,12-15,17-21,36H2	ZVJCZISSZXHAHJ-UHFFFAOYSA-N	436828	(S)-4'-((S)-6-(1H-pyrazol-1-yl)-1,4-oxazepan-4-yl)-7-amino-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidine]-8-carbonitrile ::US20260022132, Compound 516c	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 2.90							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436828	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436828&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134494011	439658457							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211669	Cn1nccc1C(=O)N1CC2(CCCCN(c3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc4c(F)c(-c5ccc(F)c6sc(N)c(C#N)c56)c(Cl)cc34)C2)C1	InChI=1S/C38H37ClF3N9O2S/c1-48-27(7-10-45-48)35(52)50-18-37(19-50)8-2-3-11-49(17-37)34-23-13-25(39)29(22-5-6-26(41)32-28(22)24(15-43)33(44)54-32)30(42)31(23)46-36(47-34)53-20-38-9-4-12-51(38)16-21(40)14-38/h5-7,10,13,21H,2-4,8-9,11-12,14,16-20,44H2,1H3	IIVOFBAPEBNFQG-UHFFFAOYSA-N	436829	5-((S)-7-amino-8-cyano-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidin]-4'-yl)-3-fluoro-N,N-dimethyl-5,6,7,8-tetrahydro-4H-pyrazolo[1,5-a][1,4]diazepine-2-carboxamide ::US20260022132, Compound 517a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 2.60							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436829	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436829&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493788	439658458							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211670	N#Cc1c(N)ccc2c1[C@]1(CCC2)Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc(N3CCOCC4(COC4)C3)c2CO1	InChI=1S/C32H39FN6O4/c33-22-11-31(6-2-8-39(31)14-22)20-42-29-36-26-12-32(7-1-3-21-4-5-25(35)23(13-34)27(21)32)43-15-24(26)28(37-29)38-9-10-40-17-30(16-38)18-41-19-30/h4-5,22H,1-3,6-12,14-20,35H2	PVVFTTZPFXNBAO-UHFFFAOYSA-N	436830	(S)-7-Amino-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-4'-(2,6-dioxa-9-azaspiro[3.6]decan-9-yl)-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidine]-8-carbonitrile ::US20260022132, Compound 518a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 9.40							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436830	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436830&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493578	439658459							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211671	CN(C)C(=O)C1COCCN(c2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc3c2CO[C@@]2(CCCc4ccc(N)c(C#N)c42)C3)C1	InChI=1S/C33H42FN7O4/c1-39(2)30(42)22-16-40(11-12-43-18-22)29-25-19-45-33(9-3-5-21-6-7-26(36)24(15-35)28(21)33)14-27(25)37-31(38-29)44-20-32-8-4-10-41(32)17-23(34)13-32/h6-7,22-23H,3-5,8-14,16-20,36H2,1-2H3	PTZKZIKSXSNAIK-UHFFFAOYSA-N	436831	4-((S)-7-amino-8-cyano-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidin]-4'-yl)-N,N-dimethyl-1,4-oxazepane-6-carboxamide ::US20260022132, Compound 519a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 18.0							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436831	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436831&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493852	439658460							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211672	Cc1c(C(=O)N(C)C)nn2c1CN(c1nc(OC[C@@]34CCCN3C[C@H](F)C4)nc3c1CO[C@@]1(CCCc4ccc(N)c(C#N)c41)C3)CCC2	InChI=1S/C36H44FN9O3/c1-22-29-19-44(12-6-14-46(29)42-31(22)33(47)43(2)3)32-26-20-49-36(11-4-7-23-8-9-27(39)25(17-38)30(23)36)16-28(26)40-34(41-32)48-21-35-10-5-13-45(35)18-24(37)15-35/h8-9,24H,4-7,10-16,18-21,39H2,1-3H3	ZQUPECFCGPIVCP-UHFFFAOYSA-N	436832	5-((S)-7-amino-8-cyano-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidin]-4'-yl)-N,N,3-trimethyl-5,6,7,8-tetrahydro-4H-pyrazolo[1,5-a][1,4]diazepine-2-carboxamide ::US20260022132, Compound 520a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			<2.50							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436832	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436832&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493803	439658461							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211673	CN(C)C(=O)c1cc2n(n1)CCCN(c1nc(OC[C@@]34CCCN3C[C@H](F)C4)nc3c1CO[C@]1(C3)C[C@@H]3C[C@@H]3c3ccc(N)cc31)C2	InChI=1S/C35H43FN8O3/c1-41(2)32(45)29-13-24-18-42(8-4-10-44(24)40-29)31-27-19-47-35(14-21-11-26(21)25-6-5-23(37)12-28(25)35)16-30(27)38-33(39-31)46-20-34-7-3-9-43(34)17-22(36)15-34/h5-6,12-13,21-22,26H,3-4,7-11,14-20,37H2,1-2H3	LJVMZXAEACSCTI-UHFFFAOYSA-N	436833	5-((1aSR,3RS,7bSR)-5-amino-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-1,1a,2,5',7b,8'-hexahydrospiro[cyclopropa[a]naphthalene-3,7'-pyrano[4,3-d]pyrimidin]-4'-yl)-N,N-dimethyl-5,6,7,8-tetrahydro-4H-pyrazolo[1,5-a][1,4]diazepine-2-carboxamide ::US20260022132, Compound 521a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 19.0							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436833	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436833&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493866	439658462							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211674	N#CC[C@H]1COCCCN1c1nc(OC[C@@]23CCCN2C[C@H](F)C3)nc2c1CO[C@@]1(CCCc3ccc(N)c(C#N)c31)C2	InChI=1S/C32H38FN7O3/c33-22-14-31(8-2-11-39(31)17-22)20-42-30-37-27-15-32(9-1-4-21-5-6-26(36)24(16-35)28(21)32)43-19-25(27)29(38-30)40-12-3-13-41-18-23(40)7-10-34/h5-6,22-23H,1-4,7-9,11-15,17-20,36H2	HTPQSDHPRMNJFO-UHFFFAOYSA-N	436834	(S)-7-Amino-4'-((S)-3-(cyanomethyl)-1,4-oxazepan-4-yl)-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidine]-8-carbonitrile ::US20260022132, Compound 522a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 17.0							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436834	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436834&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493585	439658463							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211675	CN(C)C(=O)c1cc2n(n1)CCCN(c1nc(OC[C@@H]3C[C@@H](F)CN3C)nc3c1COC1(CCCc4ccc(N)c(C#N)c41)C3)C2	InChI=1S/C33H40FN9O3/c1-40(2)31(44)27-13-22-17-42(10-5-11-43(22)39-27)30-25-19-46-33(9-4-6-20-7-8-26(36)24(15-35)29(20)33)14-28(25)37-32(38-30)45-18-23-12-21(34)16-41(23)3/h7-8,13,21,23H,4-6,9-12,14,16-19,36H2,1-3H3	JPQDJGWINKHDKL-UHFFFAOYSA-N	436835	5-(7-Amino-8-cyano-2'-(((2S,4R)-4-fluoro-1-methylpyrrolidin-2-yl)methoxy)-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidin]-4'-yl)-N,N-dimethyl-5,6,7,8-tetrahydro-4H-pyrazolo[1,5-a][1,4]diazepine-2-carboxamide ::US20260022132, Compound 523a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 6.70							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436835	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436835&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134494020	439658464							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211676	CN1CCC[C@H]1COc1nc2c(c(N3CCCOCC3)n1)COC1(CCCc3ccc(N)c(C#N)c31)C2	InChI=1S/C28H36N6O3/c1-33-10-3-6-20(33)17-36-27-31-24-15-28(9-2-5-19-7-8-23(30)21(16-29)25(19)28)37-18-22(24)26(32-27)34-11-4-13-35-14-12-34/h7-8,20H,2-6,9-15,17-18,30H2,1H3	CHJBJULDLGVBRF-UHFFFAOYSA-N	436836	7-Amino-2'-(((S)-1-methylpyrrolidin-2-yl)methoxy)-4'-(1,4-oxazepan-4-yl)-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidine]-8-carbonitrile ::US20260022132, Compound 524a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 120							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436836	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436836&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493723	439658465							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211677	CN1CC[C@@H](COc2nc3c(c(N4CCCOCC4)n2)COC2(CCCc4ccc(N)c(C#N)c42)C3)C1	InChI=1S/C28H36N6O3/c1-33-10-7-19(16-33)17-36-27-31-24-14-28(8-2-4-20-5-6-23(30)21(15-29)25(20)28)37-18-22(24)26(32-27)34-9-3-12-35-13-11-34/h5-6,19H,2-4,7-14,16-18,30H2,1H3	VPQDFNIFBIBEKF-UHFFFAOYSA-N	436837	7-Amino-2'-(((R)-1-methylpyrrolidin-3-yl)methoxy)-4'-(1,4-oxazepan-4-yl)-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidine]-8-carbonitrile ::US20260022132, Compound 525a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 1400							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436837	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436837&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134494030	439658466							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211678	CN(C)C(=O)c1cc2n(n1)CCCN(c1nc(OC[C@]3(C)CCCN3C)nc3c1COC1(CCCc4ccc(N)c(C#N)c41)C3)C2	InChI=1S/C34H43N9O3/c1-33(11-6-13-41(33)4)21-45-32-37-28-17-34(12-5-8-22-9-10-26(36)24(18-35)29(22)34)46-20-25(28)30(38-32)42-14-7-15-43-23(19-42)16-27(39-43)31(44)40(2)3/h9-10,16H,5-8,11-15,17,19-21,36H2,1-4H3	RMXYCKKQCUDHSQ-UHFFFAOYSA-N	436838	5-(7-amino-8-cyano-2'-(((S)-1,2-dimethylpyrrolidin-2-yl)methoxy)-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidin]-4'-yl)-N,N-dimethyl-5,6,7,8-tetrahydro-4H-pyrazolo[1,5-a][1,4]diazepine-2-carboxamide ::US20260022132, Compound 526a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 8.00							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436838	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436838&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493584	439658467							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211679	CN(C)C(=O)c1cc2n(n1)CCCN(c1nc(OC[C@]3(C)CCCN3C)nc3c1CO[C@]1(CCCc4ccc(N)c(C#N)c41)C3)C2	InChI=1S/C34H43N9O3/c1-33(11-6-13-41(33)4)21-45-32-37-28-17-34(12-5-8-22-9-10-26(36)24(18-35)29(22)34)46-20-25(28)30(38-32)42-14-7-15-43-23(19-42)16-27(39-43)31(44)40(2)3/h9-10,16H,5-8,11-15,17,19-21,36H2,1-4H3	RMXYCKKQCUDHSQ-UHFFFAOYSA-N	436839	US20260022132, Compound 526b	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			>10000							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436839	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436839&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493812	439658468							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211680	CN(C)C(=O)c1cc2n(n1)CCCN(c1nc(OC[C@]3(C)CCCN3C)nc3c1CO[C@@]1(CCCc4ccc(N)c(C#N)c41)C3)C2	InChI=1S/C34H43N9O3/c1-33(11-6-13-41(33)4)21-45-32-37-28-17-34(12-5-8-22-9-10-26(36)24(18-35)29(22)34)46-20-25(28)30(38-32)42-14-7-15-43-23(19-42)16-27(39-43)31(44)40(2)3/h9-10,16H,5-8,11-15,17,19-21,36H2,1-4H3	RMXYCKKQCUDHSQ-UHFFFAOYSA-N	436840	US20260022132, Compound 526c	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 6.80							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436840	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436840&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493786	439658469							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211681	C[C@H](Oc1nc2c(c(N3CCCn4nc(C(=O)N(C)C)cc4C3)n1)CO[C@@]1(CCCc3ccc(N)c(C#N)c31)C2)[C@@H]1CCCN1C	InChI=1S/C34H43N9O3/c1-21(29-9-6-13-41(29)4)46-33-37-28-17-34(12-5-8-22-10-11-26(36)24(18-35)30(22)34)45-20-25(28)31(38-33)42-14-7-15-43-23(19-42)16-27(39-43)32(44)40(2)3/h10-11,16,21,29H,5-9,12-15,17,19-20,36H2,1-4H3	AWPLGPZJDDZEDE-UHFFFAOYSA-N	436841	5-((S*)-7-amino-8-cyano-2'-((S)-1-((S)-1-methylpyrrolidin-2-yl)ethoxy)-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidin]-4'-yl)-N,N-dimethyl-5,6,7,8-tetrahydro-4H-pyrazolo[1,5-a][1,4]diazepine-2-carboxamide ::US20260022132, Compound 527a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 550							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436841	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436841&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493880	439658470							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211682	N#Cc1c(N)ccc2c1[C@]1(CCC2)Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc(N3CCOCC(c4ncco4)C3)c2CO1	InChI=1S/C33H38FN7O4/c34-23-13-32(6-2-9-41(32)17-23)20-44-31-38-27-14-33(7-1-3-21-4-5-26(36)24(15-35)28(21)33)45-19-25(27)29(39-31)40-10-12-42-18-22(16-40)30-37-8-11-43-30/h4-5,8,11,22-23H,1-3,6-7,9-10,12-14,16-20,36H2	FIPNMLYNBLKHOA-UHFFFAOYSA-N	436842	US20260022132, Compound 528a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 6.80							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436842	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436842&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493848	439658471							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211683	Cc1ncc(C2COCCN(c3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc4c3CO[C@@]3(CCCc5ccc(N)c(C#N)c53)C4)C2)o1	InChI=1S/C34H40FN7O4/c1-21-38-15-29(46-21)23-16-41(10-11-43-18-23)31-26-19-45-34(8-2-4-22-5-6-27(37)25(14-36)30(22)34)13-28(26)39-32(40-31)44-20-33-7-3-9-42(33)17-24(35)12-33/h5-6,15,23-24H,2-4,7-13,16-20,37H2,1H3	SNPVVKNQLHPPOT-UHFFFAOYSA-N	436843	(S)-7-Amino-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-4'-((SR)-6-(2-methyloxazol-5-yl)-1,4-oxazepan-4-yl)-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidine]-8-carbonitrile ::US20260022132, Compound 529a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 16.0							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436843	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436843&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493734	439658472							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211684	Cc1c(C(=O)N(C)C)nn2c1CN(c1nc(OC[C@@]34CCCN3C[C@H](F)C4)nc3c1CO[C@@]1(CC[C@H](C)c4ccc(N)c(C#N)c41)C3)CCC2	InChI=1S/C37H46FN9O3/c1-22-9-11-37(31-25(22)7-8-28(40)26(31)17-39)16-29-27(20-50-37)33(42-35(41-29)49-21-36-10-5-13-46(36)18-24(38)15-36)45-12-6-14-47-30(19-45)23(2)32(43-47)34(48)44(3)4/h7-8,22,24H,5-6,9-16,18-21,40H2,1-4H3	RVLLWXQYWDCEOI-UHFFFAOYSA-N	436844	US20260022132, Compound 530a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 2.90							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436844	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436844&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493876	439658473							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211685	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCCn5nc(C(=O)N(C)C)c(F)c5C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C36H43F2N9O3/c1-21-8-10-36(29-23(21)6-7-26(40)24(29)16-39)15-27-25(19-50-36)32(42-34(41-27)49-20-35-9-4-12-46(35)17-22(37)14-35)45-11-5-13-47-28(18-45)30(38)31(43-47)33(48)44(2)3/h6-7,21-22H,4-5,8-15,17-20,40H2,1-3H3	DXCCUIKJCGUYNI-UHFFFAOYSA-N	436845	US20260022132, Compound 531a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			<2.50							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436845	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436845&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493582	439658474							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211686	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCOC[C@@H](n5cccn5)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C34H41FN8O3/c1-22-6-8-34(30-25(22)4-5-28(37)26(30)16-36)15-29-27(20-46-34)31(41-12-13-44-19-24(18-41)43-11-3-9-38-43)40-32(39-29)45-21-33-7-2-10-42(33)17-23(35)14-33/h3-5,9,11,22-24H,2,6-8,10,12-15,17-21,37H2,1H3	UUOHEFJLIBXQFE-UHFFFAOYSA-N	436846	US20260022132, Compound 532a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			<2.50							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436846	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436846&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493701	439658475							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211687	N#C[C@]1(F)CCCN(c2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc3c2CO[C@@]2(CCCc4ccc(N)cc42)C3)CC1	InChI=1S/C31H38F2N6O2/c32-22-15-30(8-3-12-39(30)17-22)20-40-28-36-26-16-31(9-1-4-21-5-6-23(35)14-25(21)31)41-18-24(26)27(37-28)38-11-2-7-29(33,19-34)10-13-38/h5-6,14,22H,1-4,7-13,15-18,20,35H2	BZHILTOGSVYOSA-UHFFFAOYSA-N	436847	US20260022132, Compound 533a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 680							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436847	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436847&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493755	439658476							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211688	N#Cc1c(N)ccc2c1[C@]1(CCC2)Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc(N3CCC3)c2CO1	InChI=1S/C28H33FN6O2/c29-19-12-27(7-2-11-35(27)15-19)17-36-26-32-23-13-28(37-16-21(23)25(33-26)34-9-3-10-34)8-1-4-18-5-6-22(31)20(14-30)24(18)28/h5-6,19H,1-4,7-13,15-17,31H2	CZASIUIKRAFWCJ-UHFFFAOYSA-N	436848	US20260022132, Compound 534a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 10.00							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436848	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436848&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134494041	439658477							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211689	CN(C)C(=O)c1nn2c(c1Cl)CN(c1nc(OC[C@@]34CCCN3CC(F)C4)nc3c1COC1(CCCc4cc(F)c(N)c(C#N)c41)C3)CCC2	InChI=1S/C35H40ClF2N9O3/c1-44(2)32(48)30-28(36)26-17-45(9-5-11-47(26)43-30)31-23-18-50-35(8-3-6-20-12-24(38)29(40)22(15-39)27(20)35)14-25(23)41-33(42-31)49-19-34-7-4-10-46(34)16-21(37)13-34/h12,21H,3-11,13-14,16-19,40H2,1-2H3	AUTHDPSDKALYBR-UHFFFAOYSA-N	436849	US20260022132, Compound 536a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 3.30							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436849	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436849&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493576	439658478							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211690	CN(C)C(=O)c1nn2c(c1Cl)CN(c1nc(OC[C@@]34CCCN3C[C@H](F)C4)nc3c1CO[C@]1(CCCc4cc(F)c(N)c(C#N)c41)C3)CCC2	InChI=1S/C35H40ClF2N9O3/c1-44(2)32(48)30-28(36)26-17-45(9-5-11-47(26)43-30)31-23-18-50-35(8-3-6-20-12-24(38)29(40)22(15-39)27(20)35)14-25(23)41-33(42-31)49-19-34-7-4-10-46(34)16-21(37)13-34/h12,21H,3-11,13-14,16-19,40H2,1-2H3	AUTHDPSDKALYBR-UHFFFAOYSA-N	436850	US20260022132, Compound 536b	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 8300							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436850	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436850&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493793	439658479							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211691	CN(C)C(=O)c1nn2c(c1Cl)CN(c1nc(OC[C@@]34CCCN3C[C@H](F)C4)nc3c1CO[C@@]1(CCCc4cc(F)c(N)c(C#N)c41)C3)CCC2	InChI=1S/C35H40ClF2N9O3/c1-44(2)32(48)30-28(36)26-17-45(9-5-11-47(26)43-30)31-23-18-50-35(8-3-6-20-12-24(38)29(40)22(15-39)27(20)35)14-25(23)41-33(42-31)49-19-34-7-4-10-46(34)16-21(37)13-34/h12,21H,3-11,13-14,16-19,40H2,1-2H3	AUTHDPSDKALYBR-UHFFFAOYSA-N	436851	US20260022132, Compound 536c	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 3.30							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436851	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436851&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134417391	439658480							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211692	CN(C)C1CN(c2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc3c2CO[C@@]2(CCCc4ccc(N)c(C#N)c42)C3)C1	InChI=1S/C30H38FN7O2/c1-36(2)21-15-37(16-21)27-23-17-40-30(9-3-5-19-6-7-24(33)22(13-32)26(19)30)12-25(23)34-28(35-27)39-18-29-8-4-10-38(29)14-20(31)11-29/h6-7,20-21H,3-5,8-12,14-18,33H2,1-2H3	XYZWGXRBRVSJSL-UHFFFAOYSA-N	436852	US20260022132, Compound 537a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 4900							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436852	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436852&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493716	439658481							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211693	N#Cc1c(N)ccc2c1[C@]1(CCC2)Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc(N3CC4(CCOC4)C3)c2CO1	InChI=1S/C31H37FN6O3/c32-21-11-30(6-2-9-38(30)14-21)19-40-28-35-25-12-31(7-1-3-20-4-5-24(34)22(13-33)26(20)31)41-15-23(25)27(36-28)37-16-29(17-37)8-10-39-18-29/h4-5,21H,1-3,6-12,14-19,34H2	QMUAGYMYEOURIL-UHFFFAOYSA-N	436853	US20260022132, Compound 538a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 430							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436853	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436853&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493704	439658482							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211694	N#Cc1c(N)ccc2c1[C@]1(CCC2)Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc(N3CC(N4CCOCC4)C3)c2CO1	InChI=1S/C32H40FN7O3/c33-22-13-31(6-2-8-40(31)16-22)20-42-30-36-27-14-32(7-1-3-21-4-5-26(35)24(15-34)28(21)32)43-19-25(27)29(37-30)39-17-23(18-39)38-9-11-41-12-10-38/h4-5,22-23H,1-3,6-14,16-20,35H2	VVSFEJURONAHAL-UHFFFAOYSA-N	436854	US20260022132, Compound 539a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			>10000							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436854	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436854&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493592	439658483							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211695	N#Cc1c(N)ccc2c1[C@]1(CCC2)Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc(N3CC(F)C3)c2CO1	InChI=1S/C28H32F2N6O2/c29-18-9-27(6-2-8-36(27)14-18)16-37-26-33-23-10-28(38-15-21(23)25(34-26)35-12-19(30)13-35)7-1-3-17-4-5-22(32)20(11-31)24(17)28/h4-5,18-19H,1-3,6-10,12-16,32H2	SYEFMKCHHPCPPV-UHFFFAOYSA-N	436855	US20260022132, Compound 540a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 16.0							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436855	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436855&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493761	439658484							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211696	N#Cc1c(N)ccc2c1[C@]1(CCC2)Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc(N3CC(n4cccn4)C3)c2CO1	InChI=1S/C31H35FN8O2/c32-21-12-30(7-2-10-39(30)15-21)19-41-29-36-26-13-31(8-1-4-20-5-6-25(34)23(14-33)27(20)31)42-18-24(26)28(37-29)38-16-22(17-38)40-11-3-9-35-40/h3,5-6,9,11,21-22H,1-2,4,7-8,10,12-13,15-19,34H2	MFXUATBJLKPMRN-UHFFFAOYSA-N	436856	US20260022132, Compound 541a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 180							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436856	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436856&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493765	439658485							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211697	N#Cc1c(N)ccc2c1[C@]1(CCC2)Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc(N3CC(c4cccnc4)C3)c2CO1	InChI=1S/C33H36FN7O2/c34-24-12-32(8-3-11-41(32)18-24)20-42-31-38-28-13-33(9-1-4-21-6-7-27(36)25(14-35)29(21)33)43-19-26(28)30(39-31)40-16-23(17-40)22-5-2-10-37-15-22/h2,5-7,10,15,23-24H,1,3-4,8-9,11-13,16-20,36H2	NQRLIINXYHCPFI-UHFFFAOYSA-N	436857	US20260022132, Compound 542a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 6.60							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436857	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436857&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493735	439658486							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211698	CN(C)C1(c2nn3c(c2Cl)CC(c2nc(OC[C@@]45CCCN4C[C@H](F)C5)nc4c2CO[C@@]2(CCCc5ccc(N)c(C#N)c52)C4)CCC3)COC1	InChI=1S/C38H46ClFN8O3/c1-46(2)37(21-49-22-37)34-32(39)30-14-24(7-4-13-48(30)45-34)33-27-19-51-38(11-3-6-23-8-9-28(42)26(17-41)31(23)38)16-29(27)43-35(44-33)50-20-36-10-5-12-47(36)18-25(40)15-36/h8-9,24-25H,3-7,10-16,18-22,42H2,1-2H3	ZXJSNERLJGFBLN-UHFFFAOYSA-N	436858	US20260022132, Compound 543a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 120							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436858	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436858&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493596	439658487							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211699	N#Cc1c(N)ccc2c1[C@]1(CCC2)Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc(N3CC(O)(c4ccccc4)C3)c2CO1	InChI=1S/C34H37FN6O3/c35-24-14-32(11-5-13-41(32)17-24)21-43-31-38-28-15-34(12-4-6-22-9-10-27(37)25(16-36)29(22)34)44-18-26(28)30(39-31)40-19-33(42,20-40)23-7-2-1-3-8-23/h1-3,7-10,24,42H,4-6,11-15,17-21,37H2	ZTUMYVAWEMCDRU-UHFFFAOYSA-N	436859	US20260022132, Compound 544a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 580							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436859	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436859&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493882	439658488							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211700	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4CC(F)(F)C5)nc(N4CCCn5nc(C(=O)N(C)C)c(Cl)c5C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C36H42ClF2N9O3/c1-21-8-10-35(28-22(21)6-7-25(41)23(28)15-40)14-26-24(17-51-35)31(43-33(42-26)50-20-34-9-4-12-47(34)19-36(38,39)18-34)46-11-5-13-48-27(16-46)29(37)30(44-48)32(49)45(2)3/h6-7,21H,4-5,8-14,16-20,41H2,1-3H3	NWHSOFHXOXFDFX-UHFFFAOYSA-N	436860	US20260022132, Compound 546a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			<2.50							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436860	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436860&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493752	439658489							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211701	N#Cc1c(N)ccc2c1[C@]1(CCC2)Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc(N3CC4(CCO4)C3)c2CO1	InChI=1S/C30H35FN6O3/c31-20-11-28(6-2-9-37(28)14-20)18-38-27-34-24-12-30(7-1-3-19-4-5-23(33)21(13-32)25(19)30)40-15-22(24)26(35-27)36-16-29(17-36)8-10-39-29/h4-5,20H,1-3,6-12,14-18,33H2	QUOAGSMYZWIWDM-UHFFFAOYSA-N	436861	US20260022132, Compound 547a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 190							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436861	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436861&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134490024	439658490							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211702	N#Cc1c(N)ccc2c1[C@]1(CCC2)Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc(N3CC4(C3)CC4(F)F)c2CO1	InChI=1S/C30H33F3N6O2/c31-19-9-28(6-2-8-39(28)12-19)17-40-26-36-23-10-29(7-1-3-18-4-5-22(35)20(11-34)24(18)29)41-13-21(23)25(37-26)38-15-27(16-38)14-30(27,32)33/h4-5,19H,1-3,6-10,12-17,35H2	RQILTWDZEGJRDA-UHFFFAOYSA-N	436862	US20260022132, Compound 548a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 120							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436862	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436862&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134490027	439658491							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211703	CC(C)(O)C1CN(c2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc3c2CO[C@@]2(CCCc4ccc(N)c(C#N)c42)C3)C1	InChI=1S/C31H39FN6O3/c1-29(2,39)20-14-37(15-20)27-23-17-41-31(9-3-5-19-6-7-24(34)22(13-33)26(19)31)12-25(23)35-28(36-27)40-18-30-8-4-10-38(30)16-21(32)11-30/h6-7,20-21,39H,3-5,8-12,14-18,34H2,1-2H3	BONDOGADDTYJNO-UHFFFAOYSA-N	436863	US20260022132, Compound 549a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 5900							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436863	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436863&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134490025	439658492							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211704	N#Cc1c(N)ccc2c1[C@]1(CCC2)Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc(N3CCC34COC4)c2CO1	InChI=1S/C30H35FN6O3/c31-20-11-28(6-2-9-36(28)14-20)18-39-27-34-24-12-30(7-1-3-19-4-5-23(33)21(13-32)25(19)30)40-15-22(24)26(35-27)37-10-8-29(37)16-38-17-29/h4-5,20H,1-3,6-12,14-18,33H2	BHHVCVSMRRLGKB-UHFFFAOYSA-N	436864	(S)-7-Amino-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-4'-(6-oxa-1-azaspiro[3.3]heptan-1-yl)-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidine]-8-carbonitrile ::US20260022132, Compound 550a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 2.70							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436864	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436864&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134490026	439658493							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211705	N#Cc1c(N)ccc2c1[C@]1(CCC2)Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc(N3CC4(CCNC4=O)C3)c2CO1	InChI=1S/C31H36FN7O3/c32-20-11-30(6-2-10-39(30)14-20)18-41-28-36-24-12-31(7-1-3-19-4-5-23(34)21(13-33)25(19)31)42-15-22(24)26(37-28)38-16-29(17-38)8-9-35-27(29)40/h4-5,20H,1-3,6-12,14-18,34H2,(H,35,40)	QXSDUHSHRKHWBX-UHFFFAOYSA-N	436865	US20260022132, Compound 551a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 130							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436865	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436865&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134490028	439658494							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211706	N#Cc1c(N)ccc2c1[C@]1(CCC2)Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc(N3CC4(CNC(=O)C4)C3)c2CO1	InChI=1S/C31H36FN7O3/c32-20-9-30(6-2-8-39(30)13-20)18-41-28-36-24-10-31(7-1-3-19-4-5-23(34)21(12-33)26(19)31)42-14-22(24)27(37-28)38-16-29(17-38)11-25(40)35-15-29/h4-5,20H,1-3,6-11,13-18,34H2,(H,35,40)	YJWXKEOFTYLBJU-UHFFFAOYSA-N	436866	US20260022132, Compound 552a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 27.0							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436866	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436866&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134494044	439658495							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211707	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCC4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C29H35FN6O2/c1-18-6-8-29(25-20(18)4-5-23(32)21(25)14-31)13-24-22(16-38-29)26(35-9-3-10-35)34-27(33-24)37-17-28-7-2-11-36(28)15-19(30)12-28/h4-5,18-19H,2-3,6-13,15-17,32H2,1H3	BZQAJGJCZFNMAQ-UHFFFAOYSA-N	436867	US20260022132, Compound 553a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 2.70							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436867	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436867&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134494048	439658496							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211708	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCCC5(C4)NC(=O)NC5=O)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C33H39FN8O4/c1-19-6-9-33(26-21(19)4-5-24(36)22(26)14-35)13-25-23(16-46-33)27(41-10-3-8-32(17-41)28(43)39-29(44)40-32)38-30(37-25)45-18-31-7-2-11-42(31)15-20(34)12-31/h4-5,19-20H,2-3,6-13,15-18,36H2,1H3,(H2,39,40,43,44)	JJAZBFDHKAQEQK-UHFFFAOYSA-N	436868	US20260022132, Compound 554a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 3.70							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436868	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436868&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493878	439658497							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211709	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCC[C@]5(C4)NC(=O)NC5=O)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C33H39FN8O4/c1-19-6-9-33(26-21(19)4-5-24(36)22(26)14-35)13-25-23(16-46-33)27(41-10-3-8-32(17-41)28(43)39-29(44)40-32)38-30(37-25)45-18-31-7-2-11-42(31)15-20(34)12-31/h4-5,19-20H,2-3,6-13,15-18,36H2,1H3,(H2,39,40,43,44)	JJAZBFDHKAQEQK-UHFFFAOYSA-N	436869	US20260022132, Compound 554b	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			<2.50							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436869	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436869&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493589	439658498							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211710	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCC[C@@]5(C4)NC(=O)NC5=O)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C33H39FN8O4/c1-19-6-9-33(26-21(19)4-5-24(36)22(26)14-35)13-25-23(16-46-33)27(41-10-3-8-32(17-41)28(43)39-29(44)40-32)38-30(37-25)45-18-31-7-2-11-42(31)15-20(34)12-31/h4-5,19-20H,2-3,6-13,15-18,36H2,1H3,(H2,39,40,43,44)	JJAZBFDHKAQEQK-UHFFFAOYSA-N	436870	US20260022132, Compound 554c	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			<2.50							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436870	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436870&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493591	439658499							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211711	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC5(C4)CC(C)(O)C5)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C33H41FN6O3/c1-20-6-8-33(27-22(20)4-5-25(36)23(27)12-35)11-26-24(14-43-33)28(39-17-31(18-39)15-30(2,41)16-31)38-29(37-26)42-19-32-7-3-9-40(32)13-21(34)10-32/h4-5,20-21,41H,3,6-11,13-19,36H2,1-2H3	DFEDOQLCCUFRAL-UHFFFAOYSA-N	436871	US20260022132, Compound 555a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 600							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436871	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436871&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493601	439658500							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211712	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCC45COC5)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C31H37FN6O3/c1-19-5-7-31(26-21(19)3-4-24(34)22(26)13-33)12-25-23(15-41-31)27(38-10-8-30(38)16-39-17-30)36-28(35-25)40-18-29-6-2-9-37(29)14-20(32)11-29/h3-4,19-20H,2,5-12,14-18,34H2,1H3	GQGPIAPNFZYKDL-UHFFFAOYSA-N	436872	(1S,4S)-7-Amino-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-4-methyl-4'-(6-oxa-1-azaspiro[3.3]heptan-1-yl)-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidine]-8-carbonitrile ::US20260022132, Compound 556a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 2.60							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436872	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436872&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493750	439658501							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211713	C[C@H]1CC[C@@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCC45COC5)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C31H37FN6O3/c1-19-5-7-31(26-21(19)3-4-24(34)22(26)13-33)12-25-23(15-41-31)27(38-10-8-30(38)16-39-17-30)36-28(35-25)40-18-29-6-2-9-37(29)14-20(32)11-29/h3-4,19-20H,2,5-12,14-18,34H2,1H3	GQGPIAPNFZYKDL-UHFFFAOYSA-N	436873	US20260022132, Compound 556b	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 2200							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436873	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436873&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493600	439658502							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211714	CN1CCC[C@@]1(C)COc1nc2c(c(N3CCCOCC3)n1)CO[C@@]1(CCCc3ccc(N)c(C#N)c31)C2	InChI=1S/C29H38N6O3/c1-28(9-4-11-34(28)2)19-37-27-32-24-16-29(10-3-6-20-7-8-23(31)21(17-30)25(20)29)38-18-22(24)26(33-27)35-12-5-14-36-15-13-35/h7-8H,3-6,9-16,18-19,31H2,1-2H3	FSGMPQQHETYPSH-UHFFFAOYSA-N	436874	US20260022132, Compound 558a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 420							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436874	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436874&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493605	439658503							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211715	N#Cc1c(N)ccc2c1[C@]1(CCC2)Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc(N3CCOC[C@@H](n4cc(F)cn4)C3)c2CO1	InChI=1S/C33H38F2N8O3/c34-22-11-32(6-2-8-42(32)15-22)20-45-31-39-28-12-33(7-1-3-21-4-5-27(37)25(13-36)29(21)33)46-19-26(28)30(40-31)41-9-10-44-18-24(17-41)43-16-23(35)14-38-43/h4-5,14,16,22,24H,1-3,6-12,15,17-20,37H2	UVQFYXICOHIQER-UHFFFAOYSA-N	436875	US20260022132, Compound 559a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 3.70							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436875	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436875&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493590	439658504							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211716	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC(F)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C29H34F2N6O2/c1-17-5-7-29(25-20(17)3-4-23(33)21(25)11-32)10-24-22(15-39-29)26(36-12-19(31)13-36)35-27(34-24)38-16-28-6-2-8-37(28)14-18(30)9-28/h3-4,17-19H,2,5-10,12-16,33H2,1H3	FVMUTFHUQFSJHZ-UHFFFAOYSA-N	436876	US20260022132, Compound 560a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 2.70							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436876	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436876&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493873	439658505							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211717	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC(c5cccnc5)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C34H38FN7O2/c1-21-7-9-34(30-25(21)5-6-28(37)26(30)14-36)13-29-27(19-44-34)31(41-16-23(17-41)22-4-2-10-38-15-22)40-32(39-29)43-20-33-8-3-11-42(33)18-24(35)12-33/h2,4-6,10,15,21,23-24H,3,7-9,11-13,16-20,37H2,1H3	DHVLSIYBMYHZRK-UHFFFAOYSA-N	436877	US20260022132, Compound 561a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			<2.50							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436877	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436877&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493864	439658506							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211718	Cn1cc(C2COCCN(c3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc4c3CO[C@@]3(CCCc5ccc(N)c(C#N)c53)C4)C2)cn1	InChI=1S/C34H41FN8O3/c1-41-16-23(15-38-41)24-17-42(10-11-44-19-24)31-27-20-46-34(8-2-4-22-5-6-28(37)26(14-36)30(22)34)13-29(27)39-32(40-31)45-21-33-7-3-9-43(33)18-25(35)12-33/h5-6,15-16,24-25H,2-4,7-13,17-21,37H2,1H3	VKEBTILTAWAOFQ-UHFFFAOYSA-N	436878	US20260022132, Compound 562a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 8.30							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436878	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436878&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493604	439658507							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211719	N#Cc1c(N)ccc2c1[C@]1(CCC2)Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc(N3CCOCC(c4nccs4)C3)c2CO1	InChI=1S/C33H38FN7O3S/c34-23-13-32(6-2-9-41(32)17-23)20-43-31-38-27-14-33(7-1-3-21-4-5-26(36)24(15-35)28(21)33)44-19-25(27)29(39-31)40-10-11-42-18-22(16-40)30-37-8-12-45-30/h4-5,8,12,22-23H,1-3,6-7,9-11,13-14,16-20,36H2	OAUJLQRXRHIUAR-UHFFFAOYSA-N	436879	US20260022132, Compound 563a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 3.90							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436879	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436879&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493714	439658508							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211720	N#Cc1c(N)ccc2c1[C@]1(CCC2)Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc(N3CCOC[C@@H](n4ccc(F)n4)C3)c2CO1	InChI=1S/C33H38F2N8O3/c34-22-13-32(7-2-9-42(32)16-22)20-45-31-38-27-14-33(8-1-3-21-4-5-26(37)24(15-36)29(21)33)46-19-25(27)30(39-31)41-11-12-44-18-23(17-41)43-10-6-28(35)40-43/h4-6,10,22-23H,1-3,7-9,11-14,16-20,37H2	WDWKIWYHHXVGAW-UHFFFAOYSA-N	436880	US20260022132, Compound 564a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 2.60							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436880	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436880&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493713	439658509							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211721	N#Cc1c(N)ccc2c1[C@]1(CCC2)Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc(N3CCOC[C@@H](n4nccc4F)C3)c2CO1	InChI=1S/C33H38F2N8O3/c34-22-13-32(7-2-10-42(32)16-22)20-45-31-39-27-14-33(8-1-3-21-4-5-26(37)24(15-36)29(21)33)46-19-25(27)30(40-31)41-11-12-44-18-23(17-41)43-28(35)6-9-38-43/h4-6,9,22-23H,1-3,7-8,10-14,16-20,37H2	MZQWHODBEWGYFM-UHFFFAOYSA-N	436881	US20260022132, Compound 565a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 3.90							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436881	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436881&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493738	439658510							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211722	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC[C@H]4C#N)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C30H34FN7O2/c1-18-5-8-30(26-21(18)3-4-24(34)22(26)14-33)12-25-23(16-40-30)27(38-10-6-20(38)13-32)36-28(35-25)39-17-29-7-2-9-37(29)15-19(31)11-29/h3-4,18-20H,2,5-12,15-17,34H2,1H3	BCOPBZIACDBXSR-UHFFFAOYSA-N	436882	US20260022132, Compound 566a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 3.90							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436882	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436882&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134494045	439658511							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211723	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC[C@@H]4C#N)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C30H34FN7O2/c1-18-5-8-30(26-21(18)3-4-24(34)22(26)14-33)12-25-23(16-40-30)27(38-10-6-20(38)13-32)36-28(35-25)39-17-29-7-2-9-37(29)15-19(31)11-29/h3-4,18-20H,2,5-12,15-17,34H2,1H3	BCOPBZIACDBXSR-UHFFFAOYSA-N	436883	US20260022132, Compound 566b	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 3.00							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436883	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436883&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493726	439658512							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211724	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC[C@@H]4C(N)=O)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C30H36FN7O3/c1-17-5-8-30(25-19(17)3-4-22(33)20(25)13-32)12-23-21(15-41-30)27(38-10-6-24(38)26(34)39)36-28(35-23)40-16-29-7-2-9-37(29)14-18(31)11-29/h3-4,17-18,24H,2,5-12,14-16,33H2,1H3,(H2,34,39)	KSXRNVAIRXXDMN-UHFFFAOYSA-N	436884	US20260022132, Compound 567a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 3.60							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436884	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436884&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493773	439658513							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211725	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC[C@H]4C(N)=O)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C30H36FN7O3/c1-17-5-8-30(25-19(17)3-4-22(33)20(25)13-32)12-23-21(15-41-30)27(38-10-6-24(38)26(34)39)36-28(35-23)40-16-29-7-2-9-37(29)14-18(31)11-29/h3-4,17-18,24H,2,5-12,14-16,33H2,1H3,(H2,34,39)	KSXRNVAIRXXDMN-UHFFFAOYSA-N	436885	US20260022132, Compound 567b	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 3.20							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436885	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436885&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493859	439658514							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211726	CNC(=O)[C@H]1CCN1c1nc(OC[C@@]23CCCN2C[C@H](F)C3)nc2c1CO[C@@]1(CC[C@H](C)c3ccc(N)c(C#N)c31)C2	InChI=1S/C31H38FN7O3/c1-18-6-9-31(26-20(18)4-5-23(34)21(26)14-33)13-24-22(16-42-31)27(39-11-7-25(39)28(40)35-2)37-29(36-24)41-17-30-8-3-10-38(30)15-19(32)12-30/h4-5,18-19,25H,3,6-13,15-17,34H2,1-2H3,(H,35,40)	IYUWQSXZDCYNOL-UHFFFAOYSA-N	436886	US20260022132, Compound 568a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 16.0							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436886	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436886&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134494042	439658515							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211727	CNC(=O)[C@@H]1CCN1c1nc(OC[C@@]23CCCN2C[C@H](F)C3)nc2c1CO[C@@]1(CC[C@H](C)c3ccc(N)c(C#N)c31)C2	InChI=1S/C31H38FN7O3/c1-18-6-9-31(26-20(18)4-5-23(34)21(26)14-33)13-24-22(16-42-31)27(39-11-7-25(39)28(40)35-2)37-29(36-24)41-17-30-8-3-10-38(30)15-19(32)12-30/h4-5,18-19,25H,3,6-13,15-17,34H2,1-2H3,(H,35,40)	IYUWQSXZDCYNOL-UHFFFAOYSA-N	436887	US20260022132, Compound 568b	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 4.30							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436887	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436887&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493896	439658516							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211728	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC(C)(C#N)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C31H36FN7O2/c1-19-6-8-31(26-21(19)4-5-24(35)22(26)12-33)11-25-23(14-41-31)27(38-16-29(2,15-34)17-38)37-28(36-25)40-18-30-7-3-9-39(30)13-20(32)10-30/h4-5,19-20H,3,6-11,13-14,16-18,35H2,1-2H3	XYVNGIYERJPRIE-UHFFFAOYSA-N	436888	US20260022132, Compound 569a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 3.50							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436888	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436888&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134494036	439658517							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211729	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC5(CCOC5)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H39FN6O3/c1-20-5-7-32(27-22(20)3-4-25(35)23(27)13-34)12-26-24(15-42-32)28(38-16-30(17-38)8-10-40-18-30)37-29(36-26)41-19-31-6-2-9-39(31)14-21(33)11-31/h3-4,20-21H,2,5-12,14-19,35H2,1H3	LFCHWLLLMVCDQA-UHFFFAOYSA-N	436889	US20260022132, Compound 570a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 33.0							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436889	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436889&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134494052	439658518							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211730	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC5(CCCO5)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H39FN6O3/c1-20-6-9-32(27-22(20)4-5-25(35)23(27)14-34)13-26-24(16-42-32)28(38-17-31(18-38)8-3-11-41-31)37-29(36-26)40-19-30-7-2-10-39(30)15-21(33)12-30/h4-5,20-21H,2-3,6-13,15-19,35H2,1H3	USQIDDUNOFWYNW-UHFFFAOYSA-N	436890	US20260022132, Compound 571a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 12.0							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436890	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436890&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493697	439658519							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211731	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC5(CC5C#N)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H36FN7O2/c1-19-5-7-32(27-22(19)3-4-25(36)23(27)13-35)11-26-24(15-42-32)28(39-16-30(17-39)9-20(30)12-34)38-29(37-26)41-18-31-6-2-8-40(31)14-21(33)10-31/h3-4,19-21H,2,5-11,14-18,36H2,1H3	VKMDQFXCVQSYRD-UHFFFAOYSA-N	436891	US20260022132, Compound 572a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 54.0							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436891	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436891&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134494031	439658520							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211732	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4C[C@H]5COC[C@H]54)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C31H37FN6O3/c1-18-5-7-31(27-21(18)3-4-24(34)22(27)11-33)10-25-23(15-41-31)28(38-12-19-14-39-16-26(19)38)36-29(35-25)40-17-30-6-2-8-37(30)13-20(32)9-30/h3-4,18-20,26H,2,5-10,12-17,34H2,1H3	FFFIGCHXHTUULQ-UHFFFAOYSA-N	436892	US20260022132, Compound 573a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 3.60							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436892	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436892&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134494054	439658521							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211733	CNc1ccc2c(c1C#N)C1(CCC2)Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc(N3CCCn4nc(C(=O)N(C)C)c(Cl)c4C3)c2CO1	InChI=1S/C36H43ClFN9O3/c1-40-26-9-8-22-7-4-11-36(29(22)24(26)17-39)16-27-25(20-50-36)32(42-34(41-27)49-21-35-10-5-13-46(35)18-23(38)15-35)45-12-6-14-47-28(19-45)30(37)31(43-47)33(48)44(2)3/h8-9,23,40H,4-7,10-16,18-21H2,1-3H3	NYKXXFAXXVEEFV-UHFFFAOYSA-N	436893	US20260022132, Compound 574a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 35.0							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436893	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436893&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493719	439658522							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211734	CNc1ccc2c(c1C#N)[C@]1(CCC2)Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc(N3CCCn4nc(C(=O)N(C)C)c(Cl)c4C3)c2CO1	InChI=1S/C36H43ClFN9O3/c1-40-26-9-8-22-7-4-11-36(29(22)24(26)17-39)16-27-25(20-50-36)32(42-34(41-27)49-21-35-10-5-13-46(35)18-23(38)15-35)45-12-6-14-47-28(19-45)30(37)31(43-47)33(48)44(2)3/h8-9,23,40H,4-7,10-16,18-21H2,1-3H3	NYKXXFAXXVEEFV-UHFFFAOYSA-N	436894	US20260022132, Compound 574b	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 24.0							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436894	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436894&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493717	439658523							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211735	CNc1ccc2c(c1C#N)[C@@]1(CCC2)Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc(N3CCCn4nc(C(=O)N(C)C)c(Cl)c4C3)c2CO1	InChI=1S/C36H43ClFN9O3/c1-40-26-9-8-22-7-4-11-36(29(22)24(26)17-39)16-27-25(20-50-36)32(42-34(41-27)49-21-35-10-5-13-46(35)18-23(38)15-35)45-12-6-14-47-28(19-45)30(37)31(43-47)33(48)44(2)3/h8-9,23,40H,4-7,10-16,18-21H2,1-3H3	NYKXXFAXXVEEFV-UHFFFAOYSA-N	436895	US20260022132, Compound 574c	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 2800							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436895	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436895&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493729	439658524							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211736	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC[C@@H]4C(=O)N(C)C)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H40FN7O3/c1-19-7-10-32(27-21(19)5-6-24(35)22(27)15-34)14-25-23(17-43-32)28(40-12-8-26(40)29(41)38(2)3)37-30(36-25)42-18-31-9-4-11-39(31)16-20(33)13-31/h5-6,19-20,26H,4,7-14,16-18,35H2,1-3H3	KIGOPEGIBJPSKT-UHFFFAOYSA-N	436896	US20260022132, Compound 575a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 35.0							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436896	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436896&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493891	439658525							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211737	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC[C@H]4C(=O)N(C)C)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H40FN7O3/c1-19-7-10-32(27-21(19)5-6-24(35)22(27)15-34)14-25-23(17-43-32)28(40-12-8-26(40)29(41)38(2)3)37-30(36-25)42-18-31-9-4-11-39(31)16-20(33)13-31/h5-6,19-20,26H,4,7-14,16-18,35H2,1-3H3	KIGOPEGIBJPSKT-UHFFFAOYSA-N	436897	US20260022132, Compound 575b	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 46.0							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436897	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436897&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493728	439658526							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211738	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC[C@@H]4CO)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C30H37FN6O3/c1-18-5-8-30(26-21(18)3-4-24(33)22(26)13-32)12-25-23(16-40-30)27(37-10-6-20(37)15-38)35-28(34-25)39-17-29-7-2-9-36(29)14-19(31)11-29/h3-4,18-20,38H,2,5-12,14-17,33H2,1H3	RDJUPMCPGQTDON-UHFFFAOYSA-N	436898	(1S,4S)-7-Amino-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-4'-((R)-2-(hydroxymethyl)azetidin-1-yl)-4-methyl-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidine]-8-carbonitrile ::US20260022132, Compound 576a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 2.90							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436898	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436898&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493790	439658527							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211739	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC[C@H]4CO)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C30H37FN6O3/c1-18-5-8-30(26-21(18)3-4-24(33)22(26)13-32)12-25-23(16-40-30)27(37-10-6-20(37)15-38)35-28(34-25)39-17-29-7-2-9-36(29)14-19(31)11-29/h3-4,18-20,38H,2,5-12,14-17,33H2,1H3	RDJUPMCPGQTDON-UHFFFAOYSA-N	436899	US20260022132, Compound 576b	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 3.50							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436899	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436899&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493593	439658528							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211740	C[C@H]1CC[C@@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC[C@@H]4CO)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C30H37FN6O3/c1-18-5-8-30(26-21(18)3-4-24(33)22(26)13-32)12-25-23(16-40-30)27(37-10-6-20(37)15-38)35-28(34-25)39-17-29-7-2-9-36(29)14-19(31)11-29/h3-4,18-20,38H,2,5-12,14-17,33H2,1H3	RDJUPMCPGQTDON-UHFFFAOYSA-N	436900	US20260022132, Compound 576c	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 270							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436900	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436900&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493799	439658529							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211741	C[C@H]1CC[C@@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC[C@H]4CO)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C30H37FN6O3/c1-18-5-8-30(26-21(18)3-4-24(33)22(26)13-32)12-25-23(16-40-30)27(37-10-6-20(37)15-38)35-28(34-25)39-17-29-7-2-9-36(29)14-19(31)11-29/h3-4,18-20,38H,2,5-12,14-17,33H2,1H3	RDJUPMCPGQTDON-UHFFFAOYSA-N	436901	US20260022132, Compound 576d	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 390							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436901	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436901&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493609	439658530							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211742	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC5(CC(C#N)C5)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C33H38FN7O2/c1-20-5-7-33(28-23(20)3-4-26(37)24(28)14-36)12-27-25(16-43-33)29(40-17-31(18-40)9-21(10-31)13-35)39-30(38-27)42-19-32-6-2-8-41(32)15-22(34)11-32/h3-4,20-22H,2,5-12,15-19,37H2,1H3	JMXPDWAHMFLSEV-UHFFFAOYSA-N	436902	US20260022132, Compound 577a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 94.0							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436902	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436902&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493737	439658531							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211743	COC[C@H]1CCN1c1nc(OC[C@@]23CCCN2C[C@H](F)C3)nc2c1CO[C@@]1(CC[C@H](C)c3ccc(N)c(C#N)c31)C2	InChI=1S/C31H39FN6O3/c1-19-6-9-31(27-22(19)4-5-25(34)23(27)14-33)13-26-24(17-41-31)28(38-11-7-21(38)16-39-2)36-29(35-26)40-18-30-8-3-10-37(30)15-20(32)12-30/h4-5,19-21H,3,6-13,15-18,34H2,1-2H3	MSSFDNKNEQCXFM-UHFFFAOYSA-N	436903	(1S,4S)-7-Amino-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-4'-((R)-2-(methoxymethyl)azetidin-1-yl)-4-methyl-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidine]-8-carbonitrile ::US20260022132, Compound 578a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 5.30							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436903	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436903&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493814	439658532							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211744	COC[C@@H]1CCN1c1nc(OC[C@@]23CCCN2C[C@H](F)C3)nc2c1CO[C@@]1(CC[C@H](C)c3ccc(N)c(C#N)c31)C2	InChI=1S/C31H39FN6O3/c1-19-6-9-31(27-22(19)4-5-25(34)23(27)14-33)13-26-24(17-41-31)28(38-11-7-21(38)16-39-2)36-29(35-26)40-18-30-8-3-10-37(30)15-20(32)12-30/h4-5,19-21H,3,6-13,15-18,34H2,1-2H3	MSSFDNKNEQCXFM-UHFFFAOYSA-N	436904	US20260022132, Compound 578b	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 3.90							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436904	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436904&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493817	439658533							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211745	CC(C)(O)[C@H]1CCN1c1nc(OC[C@@]23CCCN2C[C@H](F)C3)nc2c1CO[C@@]1(CCCc3ccc(N)c(C#N)c31)C2	InChI=1S/C31H39FN6O3/c1-29(2,39)25-8-12-38(25)27-22-17-41-31(10-3-5-19-6-7-23(34)21(15-33)26(19)31)14-24(22)35-28(36-27)40-18-30-9-4-11-37(30)16-20(32)13-30/h6-7,20,25,39H,3-5,8-14,16-18,34H2,1-2H3	OIBJFGRCUMXUAX-UHFFFAOYSA-N	436905	US20260022132, Compound 579a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 11.0							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436905	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436905&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493785	439658534							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211746	N#Cc1c(N)ccc2c1[C@]1(CCC2)Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc(N3CCC34CCOC4)c2CO1	InChI=1S/C31H37FN6O3/c32-21-13-30(6-2-10-37(30)16-21)19-40-28-35-25-14-31(7-1-3-20-4-5-24(34)22(15-33)26(20)31)41-17-23(25)27(36-28)38-11-8-29(38)9-12-39-18-29/h4-5,21H,1-3,6-14,16-19,34H2	GISWTTUEVHIJSY-UHFFFAOYSA-N	436906	US20260022132, Compound 580a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 2.70							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436906	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436906&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493715	439658535							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211747	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCOC[C@@H](c5ncco5)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C34H40FN7O4/c1-21-5-7-34(29-24(21)3-4-27(37)25(29)15-36)14-28-26(19-46-34)30(41-10-12-43-18-22(16-41)31-38-8-11-44-31)40-32(39-28)45-20-33-6-2-9-42(33)17-23(35)13-33/h3-4,8,11,21-23H,2,5-7,9-10,12-14,16-20,37H2,1H3	DSTCBNCTDYCXIO-UHFFFAOYSA-N	436907	US20260022132, Compound 581a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 3.40							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436907	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436907&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493831	439658536							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211748	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC5(CC(C(N)=O)C5)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C33H40FN7O3/c1-19-5-7-33(27-22(19)3-4-25(36)23(27)13-35)12-26-24(15-44-33)29(40-16-31(17-40)9-20(10-31)28(37)42)39-30(38-26)43-18-32-6-2-8-41(32)14-21(34)11-32/h3-4,19-21H,2,5-12,14-18,36H2,1H3,(H2,37,42)	JBVWJBHKZZKJHM-UHFFFAOYSA-N	436908	US20260022132, Compound 582a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 13.0							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436908	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436908&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493833	439658537							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211749	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCC45CCC5)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H39FN6O2/c1-20-6-10-32(27-22(20)4-5-25(35)23(27)16-34)15-26-24(18-41-32)28(39-13-11-30(39)7-2-8-30)37-29(36-26)40-19-31-9-3-12-38(31)17-21(33)14-31/h4-5,20-21H,2-3,6-15,17-19,35H2,1H3	XJRBJOPLPRLUHN-UHFFFAOYSA-N	436909	US20260022132, Compound 583a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			<2.50							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436909	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436909&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			155295429	439658538							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211750	Cc1c(C(=O)N(C)C)nn2c1CN(c1nc(OC[C@@]34CCCN3CC(F)(F)C4)nc3c1CO[C@@]1(CC[C@H](C)c4ccc(N)c(C#N)c41)C3)CCC2	InChI=1S/C37H45F2N9O3/c1-22-9-11-36(30-24(22)7-8-27(41)25(30)16-40)15-28-26(18-51-36)32(43-34(42-28)50-21-35-10-5-13-47(35)20-37(38,39)19-35)46-12-6-14-48-29(17-46)23(2)31(44-48)33(49)45(3)4/h7-8,22H,5-6,9-15,17-21,41H2,1-4H3	VLNBTPXKAQJHJE-UHFFFAOYSA-N	436910	US20260022132, Compound 584a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			<2.50							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436910	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436910&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493708	439658539							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211751	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC[C@@]45CCCOC5)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C33H41FN6O3/c1-21-6-9-33(28-23(21)4-5-26(36)24(28)16-35)15-27-25(18-43-33)29(40-12-10-31(40)8-3-13-41-19-31)38-30(37-27)42-20-32-7-2-11-39(32)17-22(34)14-32/h4-5,21-22H,2-3,6-15,17-20,36H2,1H3	SZFNANJMUTVUTH-UHFFFAOYSA-N	436911	(1S,4S)-7-amino-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-4-methyl-4'-((R)-6-oxa-1-azaspiro[3.5]nonan-1-yl)-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidine]-8-carbonitrile ::US20260022132, Compound 585a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			<2.50							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436911	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436911&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134490032	439658540							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211752	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC[C@]45CCCOC5)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C33H41FN6O3/c1-21-6-9-33(28-23(21)4-5-26(36)24(28)16-35)15-27-25(18-43-33)29(40-12-10-31(40)8-3-13-41-19-31)38-30(37-27)42-20-32-7-2-11-39(32)17-22(34)14-32/h4-5,21-22H,2-3,6-15,17-20,36H2,1H3	SZFNANJMUTVUTH-UHFFFAOYSA-N	436912	(1S,4S)-7-amino-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-4-methyl-4'-((S)-6-oxa-1-azaspiro[3.5]nonan-1-yl)-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidine]-8-carbonitrile ::US20260022132, Compound 585b	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			<2.50							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436912	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436912&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134490033	439658541							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211753	N#Cc1c(N)ccc2c1[C@]1(CCC2)Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc(N3CC[C@@H]3C(F)F)c2CO1	InChI=1S/C29H33F3N6O2/c30-18-11-28(7-2-9-37(28)14-18)16-39-27-35-22-12-29(8-1-3-17-4-5-21(34)19(13-33)24(17)29)40-15-20(22)26(36-27)38-10-6-23(38)25(31)32/h4-5,18,23,25H,1-3,6-12,14-16,34H2	KHJQGORKOCWUMZ-UHFFFAOYSA-N	436913	US20260022132, Compound 586a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 5.60							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436913	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436913&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134490034	439658542							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211754	CN1CCC2(CCN2c2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc3c2CO[C@@]2(CCCc4ccc(N)c(C#N)c42)C3)C1	InChI=1S/C32H40FN7O2/c1-38-12-9-30(19-38)10-13-40(30)28-24-18-42-32(8-2-4-21-5-6-25(35)23(16-34)27(21)32)15-26(24)36-29(37-28)41-20-31-7-3-11-39(31)17-22(33)14-31/h5-6,22H,2-4,7-15,17-20,35H2,1H3	UBKMCASEGDXZIE-UHFFFAOYSA-N	436914	US20260022132, Compound 587a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 38.0							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436914	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436914&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134490037	439658543							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211755	CN(C)C(=O)c1cc2n(n1)CCCN(c1nc(OC[C@@]34CCCN3CC(F)(F)C4)nc3c1CO[C@@]1(CCCc4ccc(N)c(C#N)c41)C3)C2	InChI=1S/C35H41F2N9O3/c1-43(2)31(47)27-14-23-17-44(11-5-13-46(23)42-27)30-25-18-49-34(10-3-6-22-7-8-26(39)24(16-38)29(22)34)15-28(25)40-32(41-30)48-21-33-9-4-12-45(33)20-35(36,37)19-33/h7-8,14H,3-6,9-13,15,17-21,39H2,1-2H3	MVSHBSDPVANNEM-UHFFFAOYSA-N	436915	US20260022132, Compound 588a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 12.0							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436915	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436915&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134490035	439658544							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211756	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCC45CCOCC5)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C33H41FN6O3/c1-21-5-7-33(28-23(21)3-4-26(36)24(28)17-35)16-27-25(19-43-33)29(40-12-8-31(40)9-13-41-14-10-31)38-30(37-27)42-20-32-6-2-11-39(32)18-22(34)15-32/h3-4,21-22H,2,5-16,18-20,36H2,1H3	JTAFLEZGDXBACY-UHFFFAOYSA-N	436916	(1S,4S)-7-Amino-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-4-methyl-4'-(7-oxa-1-azaspiro[3.5]nonan-1-yl)-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidine]-8-carbonitrile ::US20260022132, Compound 589a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 2.80							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436916	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436916&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134490036	439658545							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211757	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4CC(F)(F)C5)nc(N4CCCn5nc(C(=O)N(C)C)c(F)c5C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C36H42F3N9O3/c1-21-8-10-35(28-22(21)6-7-25(41)23(28)15-40)14-26-24(17-51-35)31(43-33(42-26)50-20-34-9-4-12-47(34)19-36(38,39)18-34)46-11-5-13-48-27(16-46)29(37)30(44-48)32(49)45(2)3/h6-7,21H,4-5,8-14,16-20,41H2,1-3H3	DZOBLMMRJWKQMM-UHFFFAOYSA-N	436917	US20260022132, Compound 590a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			<2.50							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436917	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436917&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493893	439658546							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211758	Cc1c(C(=O)N(C)C)nn2c1CN(c1nc(OC[C@@]34CCCN3CC(F)(F)C4)nc3c1CO[C@@]1(CCCc4ccc(N)c(C#N)c41)C3)CCC2	InChI=1S/C36H43F2N9O3/c1-22-28-17-45(12-6-14-47(28)43-30(22)32(48)44(2)3)31-25-18-50-35(11-4-7-23-8-9-26(40)24(16-39)29(23)35)15-27(25)41-33(42-31)49-21-34-10-5-13-46(34)20-36(37,38)19-34/h8-9H,4-7,10-15,17-21,40H2,1-3H3	AROFIEWVOMBLME-UHFFFAOYSA-N	436918	US20260022132, Compound 591a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			<2.50							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436918	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436918&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493781	439658547							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211759	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCC4(CO)CO)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C31H39FN6O4/c1-19-5-7-31(26-21(19)3-4-24(34)22(26)13-33)12-25-23(15-42-31)27(38-10-8-30(38,16-39)17-40)36-28(35-25)41-18-29-6-2-9-37(29)14-20(32)11-29/h3-4,19-20,39-40H,2,5-12,14-18,34H2,1H3	XSNKISPQEXIIOD-UHFFFAOYSA-N	436919	(1S,4S)-7-Amino-4'-(2,2-bis(hydroxymethyl)azetidin-1-yl)-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-4-methyl-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidine]-8-carbonitrile ::US20260022132, Compound 592a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			<2.50							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436919	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436919&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493903	439658548							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211760	N#Cc1c(N)ccc2c1[C@]1(CCC2)Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc(N3CC4(CCC(=O)N4)C3)c2CO1	InChI=1S/C31H36FN7O3/c32-20-11-30(7-2-10-39(30)14-20)18-41-28-35-24-12-31(8-1-3-19-4-5-23(34)21(13-33)26(19)31)42-15-22(24)27(36-28)38-16-29(17-38)9-6-25(40)37-29/h4-5,20H,1-3,6-12,14-18,34H2,(H,37,40)	NSRVDXWKONSYMP-UHFFFAOYSA-N	436920	US20260022132, Compound 593a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 160							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436920	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436920&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493822	439658549							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211761	CN(C)C(=O)c1nn2c(c1F)CN(c1nc(OC[C@@]34CCCN3CC(F)(F)C4)nc3c1CO[C@@]1(CCCc4ccc(N)c(C#N)c41)C3)CCC2	InChI=1S/C35H40F3N9O3/c1-44(2)31(48)29-28(36)26-16-45(11-5-13-47(26)43-29)30-23-17-50-34(10-3-6-21-7-8-24(40)22(15-39)27(21)34)14-25(23)41-32(42-30)49-20-33-9-4-12-46(33)19-35(37,38)18-33/h7-8H,3-6,9-14,16-20,40H2,1-2H3	FYMHATAACKCDFX-UHFFFAOYSA-N	436921	US20260022132, Compound 594a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			<2.50							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436921	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436921&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493588	439658550							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211762	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCC4=O)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C29H33FN6O3/c1-17-5-8-29(25-19(17)3-4-22(32)20(25)13-31)12-23-21(15-39-29)26(36-10-6-24(36)37)34-27(33-23)38-16-28-7-2-9-35(28)14-18(30)11-28/h3-4,17-18H,2,5-12,14-16,32H2,1H3	FNZGKDYDOWSBAY-UHFFFAOYSA-N	436922	US20260022132, Compound 595a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 6.80							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436922	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436922&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493617	439658551							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211763	C[C@H]1CCC2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCC4=O)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C29H33FN6O3/c1-17-5-8-29(25-19(17)3-4-22(32)20(25)13-31)12-23-21(15-39-29)26(36-10-6-24(36)37)34-27(33-23)38-16-28-7-2-9-35(28)14-18(30)11-28/h3-4,17-18H,2,5-12,14-16,32H2,1H3	FNZGKDYDOWSBAY-UHFFFAOYSA-N	436923	US20260022132, Compound 595b	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 5.50							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436923	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436923&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493778	439658552							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211764	C[C@H]1CC[C@]2(Cc3nc(OCCCN4CCOCC4)nc(N4CCCn5nc(C(=O)N(C)C)c(Cl)c5C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C35H44ClN9O4/c1-22-8-9-35(29-23(22)6-7-26(38)24(29)19-37)18-27-25(21-49-35)32(40-34(39-27)48-15-5-10-43-13-16-47-17-14-43)44-11-4-12-45-28(20-44)30(36)31(41-45)33(46)42(2)3/h6-7,22H,4-5,8-18,20-21,38H2,1-3H3	KWJZINASTCWNQE-UHFFFAOYSA-N	436924	US20260022132, Compound 596a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 4.50							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436924	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436924&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493612	439658553							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211765	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC[C@]4(C)CO)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C31H39FN6O3/c1-19-6-8-31(26-21(19)4-5-24(34)22(26)14-33)13-25-23(16-41-31)27(38-11-9-29(38,2)17-39)36-28(35-25)40-18-30-7-3-10-37(30)15-20(32)12-30/h4-5,19-20,39H,3,6-13,15-18,34H2,1-2H3	HRTYKBHLPJAKIA-UHFFFAOYSA-N	436925	(1S,4S)-7-Amino-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-4'-((R)-2-(hydroxymethyl)-2-methylazetidin-1-yl)-4-methyl-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidine]-8-carbonitrile ::US20260022132, Compound 597a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 2.90							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436925	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436925&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493801	439658554							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211766	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC[C@@]4(C)CO)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C31H39FN6O3/c1-19-6-8-31(26-21(19)4-5-24(34)22(26)14-33)13-25-23(16-41-31)27(38-11-9-29(38,2)17-39)36-28(35-25)40-18-30-7-3-10-37(30)15-20(32)12-30/h4-5,19-20,39H,3,6-13,15-18,34H2,1-2H3	HRTYKBHLPJAKIA-UHFFFAOYSA-N	436926	US20260022132, Compound 597b	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 3.20							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436926	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436926&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134490038	439658555							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211767	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCC45CCOC5)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H39FN6O3/c1-20-5-7-32(27-22(20)3-4-25(35)23(27)15-34)14-26-24(17-42-32)28(39-11-8-30(39)9-12-40-18-30)37-29(36-26)41-19-31-6-2-10-38(31)16-21(33)13-31/h3-4,20-21H,2,5-14,16-19,35H2,1H3	DGUONHWWQZQJLK-UHFFFAOYSA-N	436927	(1S,4S)-7-Amino-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-4-methyl-4'-(6-oxa-1-azaspiro[3.4]octan-1-yl)-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidine]-8-carbonitrile ::US20260022132, Compound 598a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 3.70							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436927	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436927&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493753	439658556							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211768	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC[C@@]45CCOC5)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H39FN6O3/c1-20-5-7-32(27-22(20)3-4-25(35)23(27)15-34)14-26-24(17-42-32)28(39-11-8-30(39)9-12-40-18-30)37-29(36-26)41-19-31-6-2-10-38(31)16-21(33)13-31/h3-4,20-21H,2,5-14,16-19,35H2,1H3	DGUONHWWQZQJLK-UHFFFAOYSA-N	436928	(1S,4S)-7-amino-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-4-methyl-4'-((S)-6-oxa-1-azaspiro[3.4]octan-1-yl)-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidine]-8-carbonitrile ::US20260022132, Compound 598b	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 2.50							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436928	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436928&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493898	439658557							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211769	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC[C@]45CCOC5)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H39FN6O3/c1-20-5-7-32(27-22(20)3-4-25(35)23(27)15-34)14-26-24(17-42-32)28(39-11-8-30(39)9-12-40-18-30)37-29(36-26)41-19-31-6-2-10-38(31)16-21(33)13-31/h3-4,20-21H,2,5-14,16-19,35H2,1H3	DGUONHWWQZQJLK-UHFFFAOYSA-N	436929	(1S,4S)-7-amino-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-4-methyl-4'-((R)-6-oxa-1-azaspiro[3.4]octan-1-yl)-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidine]-8-carbonitrile ::US20260022132, Compound 598c	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 3.10							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436929	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436929&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493614	439658558							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211770	CO[C@@H]1CN2CCC[C@]2(COc2nc3c(c(N4CCC45COC5)n2)CO[C@@]2(CC[C@H](C)c4ccc(N)c(C#N)c42)C3)C1	InChI=1S/C32H40N6O4/c1-20-6-8-32(27-22(20)4-5-25(34)23(27)14-33)13-26-24(16-42-32)28(38-11-9-31(38)17-40-18-31)36-29(35-26)41-19-30-7-3-10-37(30)15-21(12-30)39-2/h4-5,20-21H,3,6-13,15-19,34H2,1-2H3	PTDGGNQLVBBFIK-UHFFFAOYSA-N	436930	US20260022132, Compound 599a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 66.0							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436930	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436930&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493747	439658559							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211771	CO[C@H]1CN2CCC[C@@]2(COc2nc3c(c(N4CCC45COC5)n2)CO[C@@]2(CC[C@H](C)c4ccc(N)c(C#N)c42)C3)C1	InChI=1S/C32H40N6O4/c1-20-6-8-32(27-22(20)4-5-25(34)23(27)14-33)13-26-24(16-42-32)28(38-11-9-31(38)17-40-18-31)36-29(35-26)41-19-30-7-3-10-37(30)15-21(12-30)39-2/h4-5,20-21H,3,6-13,15-19,34H2,1-2H3	PTDGGNQLVBBFIK-UHFFFAOYSA-N	436931	US20260022132, Compound 599b	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 2.90							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436931	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436931&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134494039	439658560							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211772	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4C(=O)C[C@]45CCCOC5)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C33H39FN6O4/c1-20-6-9-33(28-22(20)4-5-25(36)23(28)15-35)13-26-24(17-44-33)29(40-27(41)14-32(40)8-3-11-42-18-32)38-30(37-26)43-19-31-7-2-10-39(31)16-21(34)12-31/h4-5,20-21H,2-3,6-14,16-19,36H2,1H3	RIONOUVYDULSNP-UHFFFAOYSA-N	436932	US20260022132, Compound 600a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 5.40							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436932	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436932&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493756	439658561							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211773	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4C(=O)C[C@@]45CCCOC5)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C33H39FN6O4/c1-20-6-9-33(28-22(20)4-5-25(36)23(28)15-35)13-26-24(17-44-33)29(40-27(41)14-32(40)8-3-11-42-18-32)38-30(37-26)43-19-31-7-2-10-39(31)16-21(34)12-31/h4-5,20-21H,2-3,6-14,16-19,36H2,1H3	RIONOUVYDULSNP-UHFFFAOYSA-N	436933	US20260022132, Compound 600b	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 4.40							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436933	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436933&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493608	439658562							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211774	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCC45CCCCC5)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C34H43FN6O2/c1-22-8-12-34(29-24(22)6-7-27(37)25(29)18-36)17-28-26(20-43-34)30(41-15-13-32(41)9-3-2-4-10-32)39-31(38-28)42-21-33-11-5-14-40(33)19-23(35)16-33/h6-7,22-23H,2-5,8-17,19-21,37H2,1H3	PQJLPACRZXKYGZ-UHFFFAOYSA-N	436934	US20260022132, Compound 601a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 2.80							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436934	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436934&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493821	439658563							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211775	CN(C)C(=O)c1nn2c(c1Cl)CN(c1nc(OC[C@@]34CCCN3C[C@H](F)C4)nc3c1COC1(CCC4(CC4)c4ccc(N)c(C#N)c41)C3)CCC2	InChI=1S/C37H43ClFN9O3/c1-45(2)33(49)31-30(38)28-19-46(12-4-14-48(28)44-31)32-24-20-51-37(11-10-35(8-9-35)25-5-6-26(41)23(17-40)29(25)37)16-27(24)42-34(43-32)50-21-36-7-3-13-47(36)18-22(39)15-36/h5-6,22H,3-4,7-16,18-21,41H2,1-2H3	QKKGUHKIOUDNHE-UHFFFAOYSA-N	436935	US20260022132, Compound 602a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 5.20							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436935	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436935&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493872	439658564							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211776	N#Cc1c(N)ccc2c1[C@]1(CCC23CC3)Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc(N3CCC34COC4)c2CO1	InChI=1S/C32H37FN6O3/c33-20-12-30(4-1-10-38(30)15-20)19-41-28-36-25-13-32(42-16-22(25)27(37-28)39-11-9-31(39)17-40-18-31)8-7-29(5-6-29)23-2-3-24(35)21(14-34)26(23)32/h2-3,20H,1,4-13,15-19,35H2	MXFSKZPCOJYMTD-UHFFFAOYSA-N	436936	US20260022132, Compound 603a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			>10000							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436936	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436936&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493787	439658565							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211777	N#Cc1c(N)ccc2c1[C@@]1(CCC23CC3)Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc(N3CCC34COC4)c2CO1	InChI=1S/C32H37FN6O3/c33-20-12-30(4-1-10-38(30)15-20)19-41-28-36-25-13-32(42-16-22(25)27(37-28)39-11-9-31(39)17-40-18-31)8-7-29(5-6-29)23-2-3-24(35)21(14-34)26(23)32/h2-3,20H,1,4-13,15-19,35H2	MXFSKZPCOJYMTD-UHFFFAOYSA-N	436937	US20260022132, Compound 603b	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 6.00							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436937	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436937&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134494049	439658566							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211778	C[C@H]1CCC2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCCn5nc(C(=O)N(C)C)c(Cl)c5C4)c3CO2)c2c1ccc(O)c2C#N	InChI=1S/C36H42ClFN8O4/c1-21-8-10-36(29-23(21)6-7-28(47)24(29)16-39)15-26-25(19-50-36)32(41-34(40-26)49-20-35-9-4-12-45(35)17-22(38)14-35)44-11-5-13-46-27(18-44)30(37)31(42-46)33(48)43(2)3/h6-7,21-22,47H,4-5,8-15,17-20H2,1-3H3	KIIAARLEFZTUIU-UHFFFAOYSA-N	436938	US20260022132, Compound 604a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 3.50							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436938	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436938&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493712	439658567							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211779	C[C@H]1CC[C@@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCCn5nc(C(=O)N(C)C)c(Cl)c5C4)c3CO2)c2c1ccc(O)c2C#N	InChI=1S/C36H42ClFN8O4/c1-21-8-10-36(29-23(21)6-7-28(47)24(29)16-39)15-26-25(19-50-36)32(41-34(40-26)49-20-35-9-4-12-45(35)17-22(38)14-35)44-11-5-13-46-27(18-44)30(37)31(42-46)33(48)43(2)3/h6-7,21-22,47H,4-5,8-15,17-20H2,1-3H3	KIIAARLEFZTUIU-UHFFFAOYSA-N	436939	US20260022132, Compound 604b	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 560							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436939	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436939&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493823	439658568							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211780	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCCn5nc(C(=O)N(C)C)c(Cl)c5C4)c3CO2)c2c1ccc(O)c2C#N	InChI=1S/C36H42ClFN8O4/c1-21-8-10-36(29-23(21)6-7-28(47)24(29)16-39)15-26-25(19-50-36)32(41-34(40-26)49-20-35-9-4-12-45(35)17-22(38)14-35)44-11-5-13-46-27(18-44)30(37)31(42-46)33(48)43(2)3/h6-7,21-22,47H,4-5,8-15,17-20H2,1-3H3	KIIAARLEFZTUIU-UHFFFAOYSA-N	436940	US20260022132, Compound 604c	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			<2.50							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436940	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436940&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493802	439658569							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211781	C[C@H]1CCC2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCC45COC5)c3CO2)c2c1ccc(O)c2C#N	InChI=1S/C31H36FN5O4/c1-19-5-7-31(26-21(19)3-4-25(38)22(26)13-33)12-24-23(15-41-31)27(37-10-8-30(37)16-39-17-30)35-28(34-24)40-18-29-6-2-9-36(29)14-20(32)11-29/h3-4,19-20,38H,2,5-12,14-18H2,1H3	NHQOMQRPZLARES-UHFFFAOYSA-N	436941	US20260022132, Compound 605a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 11.0							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436941	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436941&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493845	439658570							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211782	C[C@H]1CC[C@@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCC45COC5)c3CO2)c2c1ccc(O)c2C#N	InChI=1S/C31H36FN5O4/c1-19-5-7-31(26-21(19)3-4-25(38)22(26)13-33)12-24-23(15-41-31)27(37-10-8-30(37)16-39-17-30)35-28(34-24)40-18-29-6-2-9-36(29)14-20(32)11-29/h3-4,19-20,38H,2,5-12,14-18H2,1H3	NHQOMQRPZLARES-UHFFFAOYSA-N	436942	US20260022132, Compound 605b	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 3200							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436942	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436942&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493915	439658571							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211783	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCC45COC5)c3CO2)c2c1ccc(O)c2C#N	InChI=1S/C31H36FN5O4/c1-19-5-7-31(26-21(19)3-4-25(38)22(26)13-33)12-24-23(15-41-31)27(37-10-8-30(37)16-39-17-30)35-28(34-24)40-18-29-6-2-9-36(29)14-20(32)11-29/h3-4,19-20,38H,2,5-12,14-18H2,1H3	NHQOMQRPZLARES-UHFFFAOYSA-N	436943	US20260022132, Compound 605c	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 7.70							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436943	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436943&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493851	439658572							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211784	CC[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCC45COC5)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H39FN6O3/c1-2-20-6-8-32(27-22(20)4-5-25(35)23(27)14-34)13-26-24(16-42-32)28(39-11-9-31(39)17-40-18-31)37-29(36-26)41-19-30-7-3-10-38(30)15-21(33)12-30/h4-5,20-21H,2-3,6-13,15-19,35H2,1H3	FUDDEEIXGPOEBY-UHFFFAOYSA-N	436944	US20260022132, Compound 606a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 3.90							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436944	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436944&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493806	439658573							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211785	CC[C@H]1CC[C@@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCC45COC5)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H39FN6O3/c1-2-20-6-8-32(27-22(20)4-5-25(35)23(27)14-34)13-26-24(16-42-32)28(39-11-9-31(39)17-40-18-31)37-29(36-26)41-19-30-7-3-10-38(30)15-21(33)12-30/h4-5,20-21H,2-3,6-13,15-19,35H2,1H3	FUDDEEIXGPOEBY-UHFFFAOYSA-N	436945	US20260022132, Compound 606b	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 6000							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436945	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436945&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493567	439658574							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211786	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC(CO)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C30H37FN6O3/c1-18-5-7-30(26-21(18)3-4-24(33)22(26)11-32)10-25-23(16-40-30)27(36-12-19(13-36)15-38)35-28(34-25)39-17-29-6-2-8-37(29)14-20(31)9-29/h3-4,18-20,38H,2,5-10,12-17,33H2,1H3	YHIWUUUNNDTMOQ-UHFFFAOYSA-N	436946	(1S,4S)-7-Amino-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-4'-(3-(hydroxymethyl)azetidin-1-yl)-4-methyl-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidine]-8-carbonitrile ::US20260022132, Compound 607a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 9.30							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436946	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436946&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493899	439658575							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211787	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4C(=O)C[C@@]45CCOC5)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H37FN6O4/c1-19-5-7-32(27-21(19)3-4-24(35)22(27)14-34)12-25-23(16-43-32)28(39-26(40)13-31(39)8-10-41-17-31)37-29(36-25)42-18-30-6-2-9-38(30)15-20(33)11-30/h3-4,19-20H,2,5-13,15-18,35H2,1H3	ZPWKIVPVCLLXRS-UHFFFAOYSA-N	436947	US20260022132, Compound 608a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			<2.50							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436947	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436947&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493618	439658576							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211788	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4C(=O)C[C@]45CCOC5)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H37FN6O4/c1-19-5-7-32(27-21(19)3-4-24(35)22(27)14-34)12-25-23(16-43-32)28(39-26(40)13-31(39)8-10-41-17-31)37-29(36-25)42-18-30-6-2-9-38(30)15-20(33)11-30/h3-4,19-20H,2,5-13,15-18,35H2,1H3	ZPWKIVPVCLLXRS-UHFFFAOYSA-N	436948	US20260022132, Compound 608b	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 2.90							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436948	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436948&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134494056	439658577							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211789	CC[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCC4(CO)CO)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H41FN6O4/c1-2-20-6-8-32(27-22(20)4-5-25(35)23(27)14-34)13-26-24(16-43-32)28(39-11-9-31(39,17-40)18-41)37-29(36-26)42-19-30-7-3-10-38(30)15-21(33)12-30/h4-5,20-21,40-41H,2-3,6-13,15-19,35H2,1H3	XMCFWJNJDSTPHW-UHFFFAOYSA-N	436949	US20260022132, Compound 609a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 3.70							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436949	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436949&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493615	439658578							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211790	CC[C@H]1CC[C@@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCC4(CO)CO)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H41FN6O4/c1-2-20-6-8-32(27-22(20)4-5-25(35)23(27)14-34)13-26-24(16-43-32)28(39-11-9-31(39,17-40)18-41)37-29(36-26)42-19-30-7-3-10-38(30)15-21(33)12-30/h4-5,20-21,40-41H,2-3,6-13,15-19,35H2,1H3	XMCFWJNJDSTPHW-UHFFFAOYSA-N	436950	US20260022132, Compound 609b	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 22.0							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436950	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436950&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493732	439658579							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211791	C[C@H](O)[C@H]1CCN1c1nc(OC[C@@]23CCCN2C[C@H](F)C3)nc2c1CO[C@@]1(CC[C@H](C)c3ccc(N)c(C#N)c31)C2	InChI=1S/C31H39FN6O3/c1-18-6-9-31(27-21(18)4-5-24(34)22(27)14-33)13-25-23(16-41-31)28(38-11-7-26(38)19(2)39)36-29(35-25)40-17-30-8-3-10-37(30)15-20(32)12-30/h4-5,18-20,26,39H,3,6-13,15-17,34H2,1-2H3	VUTJVMWIEMNLBI-UHFFFAOYSA-N	436951	US20260022132, Compound 610a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 4.50							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436951	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436951&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134494038	439658580							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211792	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC[C@@H]4[C@@H](C)O)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C31H39FN6O3/c1-18-6-9-31(27-21(18)4-5-24(34)22(27)14-33)13-25-23(16-41-31)28(38-11-7-26(38)19(2)39)36-29(35-25)40-17-30-8-3-10-37(30)15-20(32)12-30/h4-5,18-20,26,39H,3,6-13,15-17,34H2,1-2H3	VUTJVMWIEMNLBI-UHFFFAOYSA-N	436952	US20260022132, Compound 610b	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 2.50							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436952	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436952&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134494050	439658581							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211793	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC(F)(F)[C@@H]4CO)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C30H35F3N6O3/c1-17-5-7-29(25-19(17)3-4-22(35)20(25)11-34)10-23-21(14-42-29)26(39-15-30(32,33)24(39)13-40)37-27(36-23)41-16-28-6-2-8-38(28)12-18(31)9-28/h3-4,17-18,24,40H,2,5-10,12-16,35H2,1H3	DQAHXKQVGLPZCV-UHFFFAOYSA-N	436953	US20260022132, Compound 611a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			<2.50							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436953	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436953&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493759	439658582							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211794	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC(F)(F)[C@H]4CO)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C30H35F3N6O3/c1-17-5-7-29(25-19(17)3-4-22(35)20(25)11-34)10-23-21(14-42-29)26(39-15-30(32,33)24(39)13-40)37-27(36-23)41-16-28-6-2-8-38(28)12-18(31)9-28/h3-4,17-18,24,40H,2,5-10,12-16,35H2,1H3	DQAHXKQVGLPZCV-UHFFFAOYSA-N	436954	US20260022132, Compound 611b	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 4.10							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436954	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436954&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493754	439658583							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211795	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC[C@@H]4C)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C30H37FN6O2/c1-18-6-9-30(26-21(18)4-5-24(33)22(26)14-32)13-25-23(16-39-30)27(37-11-7-19(37)2)35-28(34-25)38-17-29-8-3-10-36(29)15-20(31)12-29/h4-5,18-20H,3,6-13,15-17,33H2,1-2H3	VSILTRBGRFUVGT-UHFFFAOYSA-N	436955	US20260022132, Compound 612a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			<2.50							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436955	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436955&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493834	439658584							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211796	C[C@@H]1CCN1c1nc(OC[C@@]23CCCN2C[C@H](F)C3)nc2c1CO[C@@]1(CC[C@H](C)c3ccc(N)c(C#N)c31)C2	InChI=1S/C30H37FN6O2/c1-18-6-9-30(26-21(18)4-5-24(33)22(26)14-32)13-25-23(16-39-30)27(37-11-7-19(37)2)35-28(34-25)38-17-29-8-3-10-36(29)15-20(31)12-29/h4-5,18-20H,3,6-13,15-17,33H2,1-2H3	VSILTRBGRFUVGT-UHFFFAOYSA-N	436956	US20260022132, Compound 612b	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			<2.50							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436956	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436956&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493895	439658585							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211797	C[C@@H]1C[C@H](C)N1c1nc(OC[C@@]23CCCN2CC(F)C3)nc2c1CO[C@@]1(CC[C@H](C)c3ccc(N)c(C#N)c31)C2	InChI=1S/C31H39FN6O2/c1-18-7-9-31(27-22(18)5-6-25(34)23(27)14-33)13-26-24(16-40-31)28(38-19(2)11-20(38)3)36-29(35-26)39-17-30-8-4-10-37(30)15-21(32)12-30/h5-6,18-21H,4,7-13,15-17,34H2,1-3H3	CGQLDBBSNPEJAS-UHFFFAOYSA-N	436957	US20260022132, Compound 613a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			<2.50							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436957	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436957&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493804	439658586							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211798	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4[C@@H](C)C[C@@H]4C)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C31H39FN6O2/c1-18-7-9-31(27-22(18)5-6-25(34)23(27)14-33)13-26-24(16-40-31)28(38-19(2)11-20(38)3)36-29(35-26)39-17-30-8-4-10-37(30)15-21(32)12-30/h5-6,18-21H,4,7-13,15-17,34H2,1-3H3	CGQLDBBSNPEJAS-UHFFFAOYSA-N	436958	US20260022132, Compound 613b	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			<2.50							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436958	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436958&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493881	439658587							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211799	C[C@@H]1C[C@@H](C)N1c1nc(OC[C@@]23CCCN2C[C@H](F)C3)nc2c1CO[C@@]1(CC[C@H](C)c3ccc(N)c(C#N)c31)C2	InChI=1S/C31H39FN6O2/c1-18-7-9-31(27-22(18)5-6-25(34)23(27)14-33)13-26-24(16-40-31)28(38-19(2)11-20(38)3)36-29(35-26)39-17-30-8-4-10-37(30)15-21(32)12-30/h5-6,18-21H,4,7-13,15-17,34H2,1-3H3	CGQLDBBSNPEJAS-UHFFFAOYSA-N	436959	US20260022132, Compound 613c	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 3.10							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436959	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436959&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493619	439658588							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211800	CC[C@H]1CCC2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCCn5nc(C(=O)N(C)C)c(Cl)c5C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C37H45ClFN9O3/c1-4-22-9-11-37(30-24(22)7-8-27(41)25(30)17-40)16-28-26(20-51-37)33(43-35(42-28)50-21-36-10-5-13-47(36)18-23(39)15-36)46-12-6-14-48-29(19-46)31(38)32(44-48)34(49)45(2)3/h7-8,22-23H,4-6,9-16,18-21,41H2,1-3H3	WTLGBYAJYMCSFK-UHFFFAOYSA-N	436960	US20260022132, Compound 614a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			<2.50							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436960	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436960&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134494063	439658589							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211801	CC[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCCn5nc(C(=O)N(C)C)c(Cl)c5C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C37H45ClFN9O3/c1-4-22-9-11-37(30-24(22)7-8-27(41)25(30)17-40)16-28-26(20-51-37)33(43-35(42-28)50-21-36-10-5-13-47(36)18-23(39)15-36)46-12-6-14-48-29(19-46)31(38)32(44-48)34(49)45(2)3/h7-8,22-23H,4-6,9-16,18-21,41H2,1-3H3	WTLGBYAJYMCSFK-UHFFFAOYSA-N	436961	US20260022132, Compound 614b	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			<2.50							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436961	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436961&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493598	439658590							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211802	Cc1cc2[nH]ncc2c(-c2ccc3c(N(C)[C@@H]4CCN(C(=O)/C(F)=C/c5nccs5)C4)nc(OC[C@@]45CCCN4C[C@H](F)C5)nc3c2F)c1Cl	InChI=1S/C35H34ClF3N8O2S/c1-19-12-26-24(15-41-44-26)28(29(19)36)22-4-5-23-31(30(22)39)42-34(49-18-35-7-3-9-47(35)16-20(37)14-35)43-32(23)45(2)21-6-10-46(17-21)33(48)25(38)13-27-40-8-11-50-27/h4-5,8,11-13,15,20-21H,3,6-7,9-10,14,16-18H2,1-2H3,(H,41,44)	RUWNSBYLNKSSIN-UHFFFAOYSA-N	436962	US20260022132, Compound 614c	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 1000							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436962	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436962&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493621	439658591							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211803	C[C@H]1CC[C@]2(Cc3nc(OCCN(C)C)nc(N4CCCn5nc(C(=O)N(C)C)c(Cl)c5C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H40ClN9O3/c1-19-9-10-32(26-20(19)7-8-23(35)21(26)16-34)15-24-22(18-45-32)29(37-31(36-24)44-14-13-39(2)3)41-11-6-12-42-25(17-41)27(33)28(38-42)30(43)40(4)5/h7-8,19H,6,9-15,17-18,35H2,1-5H3	UXFICBYXVNYQGI-UHFFFAOYSA-N	436963	US20260022132, Compound 615a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 5.70							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436963	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436963&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493763	439658592							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211804	C[C@H]1CC[C@]2(Cc3nc(OCCN(C)C)nc(N4CCCn5nc(C(=O)N(C)C)cc5C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H41N9O3/c1-20-9-10-32(28-22(20)7-8-25(34)23(28)17-33)16-27-24(19-44-32)29(36-31(35-27)43-14-13-38(2)3)40-11-6-12-41-21(18-40)15-26(37-41)30(42)39(4)5/h7-8,15,20H,6,9-14,16,18-19,34H2,1-5H3	JEDVJSDFJOULPO-UHFFFAOYSA-N	436964	US20260022132, Compound 616a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 12.0							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436964	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436964&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493758	439658593							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211805	C[C@H]1CC[C@]2(Cc3nc(OCC4(CN(C)C)CC4)nc(N4CCCn5nc(C(=O)N(C)C)c(Cl)c5C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C35H44ClN9O3/c1-21-9-10-35(28-22(21)7-8-25(38)23(28)16-37)15-26-24(18-48-35)31(40-33(39-26)47-20-34(11-12-34)19-42(2)3)44-13-6-14-45-27(17-44)29(36)30(41-45)32(46)43(4)5/h7-8,21H,6,9-15,17-20,38H2,1-5H3	BJRROEWTNCBXGW-UHFFFAOYSA-N	436965	US20260022132, Compound 617a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			<2.50							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436965	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436965&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493622	439658594							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211806	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCC[C@@H]4CO)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C31H39FN6O3/c1-19-7-9-31(27-22(19)5-6-25(34)23(27)14-33)13-26-24(17-41-31)28(38-11-2-4-21(38)16-39)36-29(35-26)40-18-30-8-3-10-37(30)15-20(32)12-30/h5-6,19-21,39H,2-4,7-13,15-18,34H2,1H3	IVJDIWPMJKYRKM-UHFFFAOYSA-N	436966	US20260022132, Compound 618a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			<2.50							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436966	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436966&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134494058	439658595							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211807	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCC4c4nccs4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H36FN7O2S/c1-19-5-8-32(27-21(19)3-4-24(35)22(27)15-34)14-25-23(17-42-32)28(40-11-6-26(40)29-36-9-12-43-29)38-30(37-25)41-18-31-7-2-10-39(31)16-20(33)13-31/h3-4,9,12,19-20,26H,2,5-8,10-11,13-14,16-18,35H2,1H3	XTQZJPFLRGPFLZ-UHFFFAOYSA-N	436967	US20260022132, Compound 619a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 5.40							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436967	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436967&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493906	439658596							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211808	COC[C@H]1CCCN1c1nc(OC[C@@]23CCCN2C[C@H](F)C3)nc2c1CO[C@@]1(CC[C@H](C)c3ccc(N)c(C#N)c31)C2	InChI=1S/C32H41FN6O3/c1-20-8-10-32(28-23(20)6-7-26(35)24(28)15-34)14-27-25(18-42-32)29(39-12-3-5-22(39)17-40-2)37-30(36-27)41-19-31-9-4-11-38(31)16-21(33)13-31/h6-7,20-22H,3-5,8-14,16-19,35H2,1-2H3	UXPXFHWACDGWEQ-UHFFFAOYSA-N	436968	US20260022132, Compound 620a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 4.50							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436968	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436968&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493744	439658597							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211809	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC[C@H]4c4ncco4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H36FN7O3/c1-19-5-8-32(27-21(19)3-4-24(35)22(27)15-34)14-25-23(17-43-32)28(40-11-6-26(40)29-36-9-12-41-29)38-30(37-25)42-18-31-7-2-10-39(31)16-20(33)13-31/h3-4,9,12,19-20,26H,2,5-8,10-11,13-14,16-18,35H2,1H3	JQDZAUVZQQXCSV-UHFFFAOYSA-N	436969	US20260022132, Compound 621a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			<2.50							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436969	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436969&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493856	439658598							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211810	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC[C@@H]4c4ncco4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H36FN7O3/c1-19-5-8-32(27-21(19)3-4-24(35)22(27)15-34)14-25-23(17-43-32)28(40-11-6-26(40)29-36-9-12-41-29)38-30(37-25)42-18-31-7-2-10-39(31)16-20(33)13-31/h3-4,9,12,19-20,26H,2,5-8,10-11,13-14,16-18,35H2,1H3	JQDZAUVZQQXCSV-UHFFFAOYSA-N	436970	US20260022132, Compound 621b	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 66.0							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436970	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436970&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493626	439658599							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211811	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4[C@H](CO)C[C@@H]4CO)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C31H39FN6O4/c1-18-5-7-31(27-22(18)3-4-25(34)23(27)12-33)11-26-24(16-42-31)28(38-20(14-39)9-21(38)15-40)36-29(35-26)41-17-30-6-2-8-37(30)13-19(32)10-30/h3-4,18-21,39-40H,2,5-11,13-17,34H2,1H3	DPLPXAKXIGWDFX-UHFFFAOYSA-N	436971	US20260022132, Compound 622a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			<2.50							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436971	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436971&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493623	439658600							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211812	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCC4(C)C)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C31H39FN6O2/c1-19-7-9-31(26-21(19)5-6-24(34)22(26)15-33)14-25-23(17-40-31)27(38-12-10-29(38,2)3)36-28(35-25)39-18-30-8-4-11-37(30)16-20(32)13-30/h5-6,19-20H,4,7-14,16-18,34H2,1-3H3	JZQLTOVZQZAHFT-UHFFFAOYSA-N	436972	US20260022132, Compound 623a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			<2.50							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436972	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436972&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493731	439658601							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211813	COC[C@@]1(CO)CCN1c1nc(OC[C@@]23CCCN2C[C@H](F)C3)nc2c1CO[C@@]1(CC[C@H](C)c3ccc(N)c(C#N)c31)C2	InChI=1S/C32H41FN6O4/c1-20-6-8-32(27-22(20)4-5-25(35)23(27)14-34)13-26-24(16-43-32)28(39-11-9-31(39,17-40)18-41-2)37-29(36-26)42-19-30-7-3-10-38(30)15-21(33)12-30/h4-5,20-21,40H,3,6-13,15-19,35H2,1-2H3	AOCHUIYXUYUARC-UHFFFAOYSA-N	436973	US20260022132, Compound 624a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 120							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436973	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436973&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493923	439658602							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211814	COC[C@]1(CO)CCN1c1nc(OC[C@@]23CCCN2C[C@H](F)C3)nc2c1CO[C@@]1(CC[C@H](C)c3ccc(N)c(C#N)c31)C2	InChI=1S/C32H41FN6O4/c1-20-6-8-32(27-22(20)4-5-25(35)23(27)14-34)13-26-24(16-43-32)28(39-11-9-31(39,17-40)18-41-2)37-29(36-26)42-19-30-7-3-10-38(30)15-21(33)12-30/h4-5,20-21,40H,3,6-13,15-19,35H2,1-2H3	AOCHUIYXUYUARC-UHFFFAOYSA-N	436974	US20260022132, Compound 624b	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			<2.50							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436974	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436974&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493857	439658603							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211815	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCCCC4=O)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C31H37FN6O3/c1-19-8-10-31(27-21(19)6-7-24(34)22(27)15-33)14-25-23(17-41-31)28(38-12-3-2-5-26(38)39)36-29(35-25)40-18-30-9-4-11-37(30)16-20(32)13-30/h6-7,19-20H,2-5,8-14,16-18,34H2,1H3	WKLDJPPYPSNPBE-UHFFFAOYSA-N	436975	US20260022132, Compound 625a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 14.0							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436975	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436975&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493774	439658604							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211816	C[C@H]1CC[C@]2(Cc3nc(OCC45CCCN4C[C@H](F)C5)nc(N4CCCOCC4=O)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C31H37FN6O4/c1-19-6-8-31(27-21(19)4-5-24(34)22(27)14-33)13-25-23(16-42-31)28(38-10-3-11-40-17-26(38)39)36-29(35-25)41-18-30-7-2-9-37(30)15-20(32)12-30/h4-5,19-20H,2-3,6-13,15-18,34H2,1H3	PWVWVJWGDKWNLR-UHFFFAOYSA-N	436976	US20260022132, Compound 626a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 5.60							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436976	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436976&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493988	439658605							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211817	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCCC4=O)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C30H35FN6O3/c1-18-7-9-30(26-20(18)5-6-23(33)21(26)14-32)13-24-22(16-40-30)27(37-11-2-4-25(37)38)35-28(34-24)39-17-29-8-3-10-36(29)15-19(31)12-29/h5-6,18-19H,2-4,7-13,15-17,33H2,1H3	IFOXRFSLHGXTSV-UHFFFAOYSA-N	436977	US20260022132, Compound 627a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 4.80							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436977	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436977&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493918	439658606							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211818	CO[C@H]1CN2CCC[C@@]2(COc2nc3c(c(N4CCCn5nc(C(=O)N(C)C)c(Cl)c5C4)n2)CO[C@@]2(CC[C@H](C)c4ccc(N)c(C#N)c42)C3)C1	InChI=1S/C37H46ClN9O4/c1-22-9-11-37(30-24(22)7-8-27(40)25(30)17-39)16-28-26(20-51-37)33(42-35(41-28)50-21-36-10-5-13-46(36)18-23(15-36)49-4)45-12-6-14-47-29(19-45)31(38)32(43-47)34(48)44(2)3/h7-8,22-23H,5-6,9-16,18-21,40H2,1-4H3	IVPTVHNQKVCOOU-UHFFFAOYSA-N	436978	US20260022132, Compound 628a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			<2.50							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436978	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436978&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493620	439658607							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211819	CO[C@H]1CN2CCC[C@@]2(COc2nc3c(c(N4CCCn5nc(C(=O)N(C)C)c(Cl)c5C4)n2)CO[C@@]2(CC[C@H](C)c4ccc(N)c(C#N)c42)C3)C1	InChI=1S/C37H46ClN9O4/c1-22-9-11-37(30-24(22)7-8-27(40)25(30)17-39)16-28-26(20-51-37)33(42-35(41-28)50-21-36-10-5-13-46(36)18-23(15-36)49-4)45-12-6-14-47-29(19-45)31(38)32(43-47)34(48)44(2)3/h7-8,22-23H,5-6,9-16,18-21,40H2,1-4H3	IVPTVHNQKVCOOU-UHFFFAOYSA-N	436979	US20260022132, Compound 628b	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			<2.50							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436979	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436979&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493920	439658608							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211820	CO[C@@H]1CN2CCC[C@]2(COc2nc3c(c(N4CCCn5nc(C(=O)N(C)C)c(Cl)c5C4)n2)CO[C@@]2(CC[C@H](C)c4ccc(N)c(C#N)c42)C3)C1	InChI=1S/C37H46ClN9O4/c1-22-9-11-37(30-24(22)7-8-27(40)25(30)17-39)16-28-26(20-51-37)33(42-35(41-28)50-21-36-10-5-13-46(36)18-23(15-36)49-4)45-12-6-14-47-29(19-45)31(38)32(43-47)34(48)44(2)3/h7-8,22-23H,5-6,9-16,18-21,40H2,1-4H3	IVPTVHNQKVCOOU-UHFFFAOYSA-N	436980	US20260022132, Compound 628c	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			<2.50							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436980	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436980&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493757	439658609							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211821	CO[C@H]1CN2CCC[C@@]2(COc2nc3c(c(N4CCCn5nc(C(=O)N(C)C)cc5C4)n2)CO[C@@]2(CC[C@H](C)c4ccc(N)c(C#N)c42)C3)C1	InChI=1S/C37H47N9O4/c1-23-9-11-37(32-26(23)7-8-29(39)27(32)18-38)17-31-28(21-50-37)33(44-12-6-14-46-24(19-44)15-30(42-46)34(47)43(2)3)41-35(40-31)49-22-36-10-5-13-45(36)20-25(16-36)48-4/h7-8,15,23,25H,5-6,9-14,16-17,19-22,39H2,1-4H3	BOIFKFVGVPXZKP-UHFFFAOYSA-N	436981	US20260022132, Compound 629a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 2.60							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436981	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436981&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134494061	439658610							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211822	C[C@H]1CC[C@]2(Cc3nc(OCC45CCCN4CCC5)nc(N4CCCn5nc(C(=O)N(C)C)c(Cl)c5C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C36H44ClN9O3/c1-22-9-12-36(29-23(22)7-8-26(39)24(29)18-38)17-27-25(20-49-36)32(41-34(40-27)48-21-35-10-4-14-45(35)15-5-11-35)44-13-6-16-46-28(19-44)30(37)31(42-46)33(47)43(2)3/h7-8,22H,4-6,9-17,19-21,39H2,1-3H3	OEPWVTRBKPEJAV-UHFFFAOYSA-N	436982	US20260022132, Compound 630a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 3.50							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436982	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436982&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134417315	439658611							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211823	CN(C)C(=O)c1nn2c(c1Cl)CN(c1nc(OC[C@@]34CCCN3CC(F)(F)C4)nc3c1CO[C@@]1(CCCc4ccc(N)c(C#N)c41)C3)CCC2	InChI=1S/C35H40ClF2N9O3/c1-44(2)31(48)29-28(36)26-16-45(11-5-13-47(26)43-29)30-23-17-50-34(10-3-6-21-7-8-24(40)22(15-39)27(21)34)14-25(23)41-32(42-30)49-20-33-9-4-12-46(33)19-35(37,38)18-33/h7-8H,3-6,9-14,16-20,40H2,1-2H3	RBMRGHGQRJSAOA-UHFFFAOYSA-N	436983	US20260022132, Compound 631a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 7.60							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436983	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436983&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134494057	439658612							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211824	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4CC(F)(F)C5)nc(N4CCCn5nc(C(=O)N(C)C)cc5C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C36H43F2N9O3/c1-22-8-10-35(30-24(22)6-7-27(40)25(30)16-39)15-29-26(18-50-35)31(45-11-5-13-47-23(17-45)14-28(43-47)32(48)44(2)3)42-33(41-29)49-21-34-9-4-12-46(34)20-36(37,38)19-34/h6-7,14,22H,4-5,8-13,15,17-21,40H2,1-3H3	GHNPIYQEQFPAIH-UHFFFAOYSA-N	436984	US20260022132, Compound 632a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 41.0							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436984	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436984&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493858	439658613							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211825	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCOCC4=O)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C30H35FN6O4/c1-18-5-7-30(26-20(18)3-4-23(33)21(26)13-32)12-24-22(15-41-30)27(37-9-10-39-16-25(37)38)35-28(34-24)40-17-29-6-2-8-36(29)14-19(31)11-29/h3-4,18-19H,2,5-12,14-17,33H2,1H3	VLFMTNJLXHADIO-UHFFFAOYSA-N	436985	US20260022132, Compound 635a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 3.70							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436985	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436985&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493813	439658614							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211826	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCOCCC4=O)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C31H37FN6O4/c1-19-5-8-31(27-21(19)3-4-24(34)22(27)15-33)14-25-23(17-42-31)28(38-10-12-40-11-6-26(38)39)36-29(35-25)41-18-30-7-2-9-37(30)16-20(32)13-30/h3-4,19-20H,2,5-14,16-18,34H2,1H3	UFYFQRKPTFFKMM-UHFFFAOYSA-N	436986	US20260022132, Compound 636a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 36.0							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436986	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436986&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493916	439658615							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211827	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCC[C@]4(C)CO)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H41FN6O3/c1-20-7-10-32(27-22(20)5-6-25(35)23(27)15-34)14-26-24(17-42-32)28(39-12-3-8-30(39,2)18-40)37-29(36-26)41-19-31-9-4-11-38(31)16-21(33)13-31/h5-6,20-21,40H,3-4,7-14,16-19,35H2,1-2H3	NEOIEWLVNQDZBU-UHFFFAOYSA-N	436987	US20260022132, Compound 637a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			<2.50							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436987	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436987&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134490039	439658616							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211828	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCC[C@@]4(C)CO)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H41FN6O3/c1-20-7-10-32(27-22(20)5-6-25(35)23(27)15-34)14-26-24(17-42-32)28(39-12-3-8-30(39,2)18-40)37-29(36-26)41-19-31-9-4-11-38(31)16-21(33)13-31/h5-6,20-21,40H,3-4,7-14,16-19,35H2,1-2H3	NEOIEWLVNQDZBU-UHFFFAOYSA-N	436988	US20260022132, Compound 637b	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 3.30							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436988	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436988&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134494064	439658617							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211829	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCCC45COC5)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H39FN6O3/c1-20-6-9-32(27-22(20)4-5-25(35)23(27)14-34)13-26-24(16-42-32)28(39-11-3-8-31(39)17-40-18-31)37-29(36-26)41-19-30-7-2-10-38(30)15-21(33)12-30/h4-5,20-21H,2-3,6-13,15-19,35H2,1H3	IZFDETJGNCHIHJ-UHFFFAOYSA-N	436989	US20260022132, Compound 638a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 3.70							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436989	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436989&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493599	439658618							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211830	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC(C)(C)[C@@H]4CO)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H41FN6O3/c1-19-7-9-32(27-21(19)5-6-24(35)22(27)13-34)12-25-23(16-42-32)28(39-17-30(2,3)26(39)15-40)37-29(36-25)41-18-31-8-4-10-38(31)14-20(33)11-31/h5-6,19-20,26,40H,4,7-12,14-18,35H2,1-3H3	HTOYXIRZIQWTFM-UHFFFAOYSA-N	436992	US20260022132, Compound 639a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 6.70							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436992	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436992&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134494068	439658621							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211831	C[C@@H]1C[C@H](CO)N1c1nc(OC[C@@]23CCCN2C[C@H](F)C3)nc2c1CO[C@@]1(CC[C@H](C)c3ccc(N)c(C#N)c31)C2	InChI=1S/C31H39FN6O3/c1-18-6-8-31(27-22(18)4-5-25(34)23(27)13-33)12-26-24(16-41-31)28(38-19(2)10-21(38)15-39)36-29(35-26)40-17-30-7-3-9-37(30)14-20(32)11-30/h4-5,18-21,39H,3,6-12,14-17,34H2,1-2H3	CQAVGXILPOPRIZ-UHFFFAOYSA-N	436993	(1S,4S)-7-Amino-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-4'-((2R,4R)-2-(hydroxymethyl)-4-methylazetidin-1-yl)-4-methyl-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidine]-8-carbonitrile ::US20260022132, Compound 640a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			<2.50							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436993	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436993&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493805	439658622							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211832	C[C@H]1CCC2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCCn5nc(C(=O)N(C)C)c(Cl)c5C4)c3CO2)c2c1cc(F)c(N)c2C#N	InChI=1S/C36H42ClF2N9O3/c1-20-6-8-36(28-22(20)12-25(39)30(41)23(28)15-40)14-26-24(18-51-36)32(43-34(42-26)50-19-35-7-4-10-47(35)16-21(38)13-35)46-9-5-11-48-27(17-46)29(37)31(44-48)33(49)45(2)3/h12,20-21H,4-11,13-14,16-19,41H2,1-3H3	OMOWVWMFRSPMOZ-UHFFFAOYSA-N	436994	US20260022132, Compound 641a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 3.10							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436994	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436994&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493874	439658623							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211833	N#CC[C@H]1CN(c2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc3c(F)c(-c4c(C)ccc5[nH]ncc45)ccc23)CCN1C(=O)/C(F)=C/c1nccs1	InChI=1S/C36H34F3N9O2S/c1-21-3-6-28-26(17-42-45-28)30(21)24-4-5-25-32(31(24)39)43-35(50-20-36-8-2-11-47(36)18-22(37)16-36)44-33(25)46-12-13-48(23(19-46)7-9-40)34(49)27(38)15-29-41-10-14-51-29/h3-6,10,14-15,17,22-23H,2,7-8,11-13,16,18-20H2,1H3,(H,42,45)	QHCHTMRGWLBBAS-UHFFFAOYSA-N	436995	US20260022132, Compound 641b	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			<2.50							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436995	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436995&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493783	439658624							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211834	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCCn5nc(C(=O)N(C)C)c(Cl)c5C4)c3CO2)c2c1cc(F)c(N)c2C#N	InChI=1S/C36H42ClF2N9O3/c1-20-6-8-36(28-22(20)12-25(39)30(41)23(28)15-40)14-26-24(18-51-36)32(43-34(42-26)50-19-35-7-4-10-47(35)16-21(38)13-35)46-9-5-11-48-27(17-46)29(37)31(44-48)33(49)45(2)3/h12,20-21H,4-11,13-14,16-19,41H2,1-3H3	OMOWVWMFRSPMOZ-UHFFFAOYSA-N	436996	US20260022132, Compound 641c	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 44.0							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436996	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436996&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493627	439658625							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211835	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCCC45CCOC5)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C33H41FN6O3/c1-21-6-9-33(28-23(21)4-5-26(36)24(28)16-35)15-27-25(18-43-33)29(40-12-3-7-31(40)10-13-41-19-31)38-30(37-27)42-20-32-8-2-11-39(32)17-22(34)14-32/h4-5,21-22H,2-3,6-15,17-20,36H2,1H3	SBECINMRVIKQRS-UHFFFAOYSA-N	436997	US20260022132, Compound 642a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 2.90							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436997	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436997&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134490043	439658626							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211836	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCC[C@@H]4C)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C31H39FN6O2/c1-19-8-10-31(27-22(19)6-7-25(34)23(27)15-33)14-26-24(17-40-31)28(38-12-3-5-20(38)2)36-29(35-26)39-18-30-9-4-11-37(30)16-21(32)13-30/h6-7,19-21H,3-5,8-14,16-18,34H2,1-2H3	IHFQUIFNKJDARV-UHFFFAOYSA-N	436998	US20260022132, Compound 643a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 2.50							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436998	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436998&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493931	439658627							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211837	C[C@@H]1CCCN1c1nc(OC[C@@]23CCCN2C[C@H](F)C3)nc2c1CO[C@@]1(CC[C@H](C)c3ccc(N)c(C#N)c31)C2	InChI=1S/C31H39FN6O2/c1-19-8-10-31(27-22(19)6-7-25(34)23(27)15-33)14-26-24(17-40-31)28(38-12-3-5-20(38)2)36-29(35-26)39-18-30-9-4-11-37(30)16-21(32)13-30/h6-7,19-21H,3-5,8-14,16-18,34H2,1-2H3	IHFQUIFNKJDARV-UHFFFAOYSA-N	436999	US20260022132, Compound 643b	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 2.80							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436999	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436999&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134494066	439658628							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211838	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCC5(COC5)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H39FN6O3/c1-20-5-7-32(27-22(20)3-4-25(35)23(27)13-34)12-26-24(15-42-32)28(38-10-8-30(16-38)17-40-18-30)37-29(36-26)41-19-31-6-2-9-39(31)14-21(33)11-31/h3-4,20-21H,2,5-12,14-19,35H2,1H3	QARPBRXFHMNRJT-UHFFFAOYSA-N	437000	US20260022132, Compound 644a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 9.20							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437000	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437000&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493628	439658629							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211839	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCC[C@H]4C#N)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C31H36FN7O2/c1-19-7-9-31(27-22(19)5-6-25(35)23(27)15-34)13-26-24(17-41-31)28(39-11-2-4-21(39)14-33)37-29(36-26)40-18-30-8-3-10-38(30)16-20(32)12-30/h5-6,19-21H,2-4,7-13,16-18,35H2,1H3	XDEDHBFKPBMMLQ-UHFFFAOYSA-N	437001	US20260022132, Compound 645a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 4.80							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437001	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437001&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134494069	439658630							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211840	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCC[C@@H]4C#N)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C31H36FN7O2/c1-19-7-9-31(27-22(19)5-6-25(35)23(27)15-34)13-26-24(17-41-31)28(39-11-2-4-21(39)14-33)37-29(36-26)40-18-30-8-3-10-38(30)16-20(32)12-30/h5-6,19-21H,2-4,7-13,16-18,35H2,1H3	XDEDHBFKPBMMLQ-UHFFFAOYSA-N	437002	US20260022132, Compound 645b	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 3.90							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437002	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437002&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493606	439658631							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211841	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4C[C@H]5COC[C@H]5C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H39FN6O3/c1-19-5-7-32(28-23(19)3-4-26(35)24(28)11-34)10-27-25(17-42-32)29(38-12-20-15-40-16-21(20)13-38)37-30(36-27)41-18-31-6-2-8-39(31)14-22(33)9-31/h3-4,19-22H,2,5-10,12-18,35H2,1H3	VRUYRSYRCGTULZ-UHFFFAOYSA-N	437003	US20260022132, Compound 646a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 8.70							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437003	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437003&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134490044	439658632							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211842	C[C@H]7CC[C@]5(Cc4nc(OC[C@@]12CCCN1C[C@H](F)C2)nc(N3CC[C@@H](O)C3)c4CO5)c6c(C#N)c(N)ccc67	InChI=1S/C31H38FN5O3/c1-3-22-25(33)6-5-23-19(2)7-10-31(27(22)23)14-26-24(17-40-31)28(36-12-8-21(38)16-36)35-29(34-26)39-18-30-9-4-11-37(30)15-20(32)13-30/h1,5-6,19-21,38H,4,7-18,33H2,2H3	YEHMEZYZYYIVHP-UHFFFAOYSA-N	437004	US20260022132, Compound 647a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 4.90							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437004	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437004&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134490045	439658633							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211843	C[C@H]7CC[C@]5(Cc4nc(OC[C@@]12CCCN1C[C@H](F)C2)nc(N3CC[C@H](O)C3)c4CO5)c6c(C#N)c(N)ccc67	InChI=1S/C31H38FN5O3/c1-3-22-25(33)6-5-23-19(2)7-10-31(27(22)23)14-26-24(17-40-31)28(36-12-8-21(38)16-36)35-29(34-26)39-18-30-9-4-11-37(30)15-20(32)13-30/h1,5-6,19-21,38H,4,7-18,33H2,2H3	YEHMEZYZYYIVHP-UHFFFAOYSA-N	437005	US20260022132, Compound 647b	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 3.70							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437005	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437005&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134490048	439658634							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211844	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC[C@@H](F)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C30H36F2N6O2/c1-18-5-8-30(26-21(18)3-4-24(34)22(26)13-33)12-25-23(16-40-30)27(37-10-6-19(31)14-37)36-28(35-25)39-17-29-7-2-9-38(29)15-20(32)11-29/h3-4,18-20H,2,5-12,14-17,34H2,1H3	FIFKBNCMFNVVJI-UHFFFAOYSA-N	437006	US20260022132, Compound 648a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 3.90							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437006	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437006&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134490046	439658635							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211845	C[C@H]7CC[C@]5(Cc4nc(OC[C@@]12CCCN1C[C@H](F)C2)nc(N3CC[C@H](F)C3)c4CO5)c6c(C#N)c(N)ccc67	InChI=1S/C31H37F2N5O2/c1-3-22-25(34)6-5-23-19(2)7-10-31(27(22)23)14-26-24(17-40-31)28(37-12-8-20(32)15-37)36-29(35-26)39-18-30-9-4-11-38(30)16-21(33)13-30/h1,5-6,19-21H,4,7-18,34H2,2H3	GUHGAJSCTDCYBF-UHFFFAOYSA-N	437007	US20260022132, Compound 648b	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 3.90							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437007	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437007&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134490047	439658636							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211846	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC[C@@H](CO)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C31H39FN6O3/c1-19-5-8-31(27-22(19)3-4-25(34)23(27)13-33)12-26-24(17-41-31)28(37-10-6-20(14-37)16-39)36-29(35-26)40-18-30-7-2-9-38(30)15-21(32)11-30/h3-4,19-21,39H,2,5-12,14-18,34H2,1H3	HSJSXJXGHTYHOS-UHFFFAOYSA-N	437008	US20260022132, Compound 649a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 4.90							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437008	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437008&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134490049	439658637							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211847	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC[C@H](CO)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C31H39FN6O3/c1-19-5-8-31(27-22(19)3-4-25(34)23(27)13-33)12-26-24(17-41-31)28(37-10-6-20(14-37)16-39)36-29(35-26)40-18-30-7-2-9-38(30)15-21(32)11-30/h3-4,19-21,39H,2,5-12,14-18,34H2,1H3	HSJSXJXGHTYHOS-UHFFFAOYSA-N	437009	US20260022132, Compound 649b	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 5.10							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437009	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437009&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134490050	439658638							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211848	N#C[C@@H]1C[C@@H](O)CN1c1nc(OC[C@@]23CCCN2C[C@H](F)C3)nc2c1CO[C@@]1(CC[C@H](C)c3ccc(N)c(C#N)c31)C2	InChI=1S/C31H36FN7O3/c1-18-5-7-31(27-22(18)3-4-25(35)23(27)13-34)11-26-24(16-42-31)28(39-15-21(40)9-20(39)12-33)37-29(36-26)41-17-30-6-2-8-38(30)14-19(32)10-30/h3-4,18-21,40H,2,5-11,14-17,35H2,1H3	COVJVOAJFJQESS-UHFFFAOYSA-N	437010	US20260022132, Compound 650a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 3.70							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437010	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437010&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134490051	439658639							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211849	N#C[C@@H]1C[C@H](O)CN1c1nc(OC[C@@]23CCCN2C[C@H](F)C3)nc2c1CO[C@@]1(CC[C@H](C)c3ccc(N)c(C#N)c31)C2	InChI=1S/C31H36FN7O3/c1-18-5-7-31(27-22(18)3-4-25(35)23(27)13-34)11-26-24(16-42-31)28(39-15-21(40)9-20(39)12-33)37-29(36-26)41-17-30-6-2-8-38(30)14-19(32)10-30/h3-4,18-21,40H,2,5-11,14-17,35H2,1H3	COVJVOAJFJQESS-UHFFFAOYSA-N	437011	US20260022132, Compound 650b	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 3.70							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437011	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437011&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134490052	439658640							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211850	N#C[C@H]1C[C@H](O)CN1c1nc(OC[C@@]23CCCN2C[C@H](F)C3)nc2c1CO[C@@]1(CC[C@H](C)c3ccc(N)c(C#N)c31)C2	InChI=1S/C31H36FN7O3/c1-18-5-7-31(27-22(18)3-4-25(35)23(27)13-34)11-26-24(16-42-31)28(39-15-21(40)9-20(39)12-33)37-29(36-26)41-17-30-6-2-8-38(30)14-19(32)10-30/h3-4,18-21,40H,2,5-11,14-17,35H2,1H3	COVJVOAJFJQESS-UHFFFAOYSA-N	437012	US20260022132, Compound 650c	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 17.0							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437012	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437012&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134490053	439658641							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211851	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4C[C@H](O)C[C@@H]4C#N)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C31H36FN7O3/c1-18-5-7-31(27-22(18)3-4-25(35)23(27)13-34)11-26-24(16-42-31)28(39-15-21(40)9-20(39)12-33)37-29(36-26)41-17-30-6-2-8-38(30)14-19(32)10-30/h3-4,18-21,40H,2,5-11,14-17,35H2,1H3	COVJVOAJFJQESS-UHFFFAOYSA-N	437013	US20260022132, Compound 650d	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 8.00							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437013	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437013&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134490054	439658642							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211852	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4C[C@H](O)C[C@H]4C(N)=O)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C31H38FN7O4/c1-17-5-7-31(26-20(17)3-4-23(34)21(26)12-33)11-24-22(15-43-31)28(39-14-19(40)9-25(39)27(35)41)37-29(36-24)42-16-30-6-2-8-38(30)13-18(32)10-30/h3-4,17-19,25,40H,2,5-11,13-16,34H2,1H3,(H2,35,41)	XRWAVKHHFUDCKC-UHFFFAOYSA-N	437014	US20260022132, Compound 651a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 5.40							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437014	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437014&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134490055	439658643							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211853	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4C[C@@H](O)C[C@H]4C(N)=O)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C31H38FN7O4/c1-17-5-7-31(26-20(17)3-4-23(34)21(26)12-33)11-24-22(15-43-31)28(39-14-19(40)9-25(39)27(35)41)37-29(36-24)42-16-30-6-2-8-38(30)13-18(32)10-30/h3-4,17-19,25,40H,2,5-11,13-16,34H2,1H3,(H2,35,41)	XRWAVKHHFUDCKC-UHFFFAOYSA-N	437015	US20260022132, Compound 651b	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 9.30							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437015	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437015&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134490056	439658644							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211854	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCC5(CCO5)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H39FN6O3/c1-20-5-7-32(27-22(20)3-4-25(35)23(27)15-34)14-26-24(17-42-32)28(38-11-8-31(18-38)9-12-41-31)37-29(36-26)40-19-30-6-2-10-39(30)16-21(33)13-30/h3-4,20-21H,2,5-14,16-19,35H2,1H3	RTKFNUOAOVWERI-UHFFFAOYSA-N	437016	US20260022132, Compound 652a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 45.0							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437016	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437016&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134490057	439658645							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211855	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC[C@@]5(CCO5)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H39FN6O3/c1-20-5-7-32(27-22(20)3-4-25(35)23(27)15-34)14-26-24(17-42-32)28(38-11-8-31(18-38)9-12-41-31)37-29(36-26)40-19-30-6-2-10-39(30)16-21(33)13-30/h3-4,20-21H,2,5-14,16-19,35H2,1H3	RTKFNUOAOVWERI-UHFFFAOYSA-N	437017	US20260022132, Compound 652b	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 110							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437017	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437017&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134490058	439658646							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211856	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC[C@]5(CCO5)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H39FN6O3/c1-20-5-7-32(27-22(20)3-4-25(35)23(27)15-34)14-26-24(17-42-32)28(38-11-8-31(18-38)9-12-41-31)37-29(36-26)40-19-30-6-2-10-39(30)16-21(33)13-30/h3-4,20-21H,2,5-14,16-19,35H2,1H3	RTKFNUOAOVWERI-UHFFFAOYSA-N	437018	US20260022132, Compound 652c	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 28.0							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437018	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437018&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134490059	439658647							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211857	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4C[C@H](C)[C@@H]4CO)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C31H39FN6O3/c1-18-6-8-31(27-21(18)4-5-24(34)22(27)12-33)11-25-23(16-41-31)28(38-13-19(2)26(38)15-39)36-29(35-25)40-17-30-7-3-9-37(30)14-20(32)10-30/h4-5,18-20,26,39H,3,6-11,13-17,34H2,1-2H3	ZBBUKADONAIUOW-UHFFFAOYSA-N	437019	US20260022132, Compound 653a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 2.90							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437019	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437019&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134490062	439658648							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211858	C[C@@H]1CN(c2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc3c2CO[C@@]2(CC[C@H](C)c4ccc(N)c(C#N)c42)C3)[C@H]1CO	InChI=1S/C31H39FN6O3/c1-18-6-8-31(27-21(18)4-5-24(34)22(27)12-33)11-25-23(16-41-31)28(38-13-19(2)26(38)15-39)36-29(35-25)40-17-30-7-3-9-37(30)14-20(32)10-30/h4-5,18-20,26,39H,3,6-11,13-17,34H2,1-2H3	ZBBUKADONAIUOW-UHFFFAOYSA-N	437020	US20260022132, Compound 653b	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 2.70							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437020	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437020&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134490063	439658649							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211859	CO[C@H]1CN2CCC[C@@]2(COc2nc3c(c(N4CC[C@@]45CCOC5)n2)CO[C@@]2(CC[C@H](C)c4ccc(N)c(C#N)c42)C3)C1	InChI=1S/C33H42N6O4/c1-21-6-8-33(28-23(21)4-5-26(35)24(28)16-34)15-27-25(18-43-33)29(39-12-9-31(39)10-13-41-19-31)37-30(36-27)42-20-32-7-3-11-38(32)17-22(14-32)40-2/h4-5,21-22H,3,6-15,17-20,35H2,1-2H3	DWLNIOPNCRBZDB-UHFFFAOYSA-N	437021	US20260022132, Compound 654a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			<2.50							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437021	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437021&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134490060	439658650							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211860	CO[C@@H]1CN2CCC[C@]2(COc2nc3c(c(N4CC[C@@]45CCOC5)n2)CO[C@@]2(CC[C@H](C)c4ccc(N)c(C#N)c42)C3)C1	InChI=1S/C33H42N6O4/c1-21-6-8-33(28-23(21)4-5-26(35)24(28)16-34)15-27-25(18-43-33)29(39-12-9-31(39)10-13-41-19-31)37-30(36-27)42-20-32-7-3-11-38(32)17-22(14-32)40-2/h4-5,21-22H,3,6-15,17-20,35H2,1-2H3	DWLNIOPNCRBZDB-UHFFFAOYSA-N	437022	US20260022132, Compound 654b	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 2.90							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437022	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437022&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134490061	439658651							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211861	CO[C@@H]1CN2CCC[C@]2(COc2nc3c(c(N4CC[C@]45CCOC5)n2)CO[C@@]2(CC[C@H](C)c4ccc(N)c(C#N)c42)C3)C1	InChI=1S/C33H42N6O4/c1-21-6-8-33(28-23(21)4-5-26(35)24(28)16-34)15-27-25(18-43-33)29(39-12-9-31(39)10-13-41-19-31)37-30(36-27)42-20-32-7-3-11-38(32)17-22(14-32)40-2/h4-5,21-22H,3,6-15,17-20,35H2,1-2H3	DWLNIOPNCRBZDB-UHFFFAOYSA-N	437023	US20260022132, Compound 654c	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			<2.50							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437023	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437023&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134490064	439658652							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211862	CO[C@H]1CN2CCC[C@@]2(COc2nc3c(c(N4CC[C@]45CCOC5)n2)CO[C@@]2(CC[C@H](C)c4ccc(N)c(C#N)c42)C3)C1	InChI=1S/C33H42N6O4/c1-21-6-8-33(28-23(21)4-5-26(35)24(28)16-34)15-27-25(18-43-33)29(39-12-9-31(39)10-13-41-19-31)37-30(36-27)42-20-32-7-3-11-38(32)17-22(14-32)40-2/h4-5,21-22H,3,6-15,17-20,35H2,1-2H3	DWLNIOPNCRBZDB-UHFFFAOYSA-N	437024	US20260022132, Compound 654d	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			<2.50							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437024	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437024&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134490065	439658653							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211863	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4[C@@H](C)CC[C@@H]4C)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H41FN6O2/c1-19-9-11-32(28-23(19)7-8-26(35)24(28)15-34)14-27-25(17-41-32)29(39-20(2)5-6-21(39)3)37-30(36-27)40-18-31-10-4-12-38(31)16-22(33)13-31/h7-8,19-22H,4-6,9-14,16-18,35H2,1-3H3	IJAQFMFQRQRMQA-UHFFFAOYSA-N	437025	US20260022132, Compound 655a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 2.50							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437025	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437025&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134490066	439658654							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211864	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCC[C@H]4C(N)=O)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C31H38FN7O3/c1-18-7-9-31(26-20(18)5-6-23(34)21(26)14-33)13-24-22(16-42-31)28(39-11-2-4-25(39)27(35)40)37-29(36-24)41-17-30-8-3-10-38(30)15-19(32)12-30/h5-6,18-19,25H,2-4,7-13,15-17,34H2,1H3,(H2,35,40)	GUGFKPRHXBRWJX-UHFFFAOYSA-N	437026	US20260022132, Compound 656a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 2.80							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437026	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437026&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134490070	439658655							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211865	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4C(=O)CC[C@@H]4CN)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C31H38FN7O3/c1-18-7-9-31(27-21(18)4-5-24(35)22(27)14-34)12-25-23(16-42-31)28(39-20(13-33)3-6-26(39)40)37-29(36-25)41-17-30-8-2-10-38(30)15-19(32)11-30/h4-5,18-20H,2-3,6-13,15-17,33,35H2,1H3	CUDSWDHLYNVFJI-UHFFFAOYSA-N	437027	US20260022132, Compound 657a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 29.0							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437027	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437027&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134490067	439658656							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211866	CC1CN(c2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc3c2CO[C@@]2(CC[C@H](C)c4ccc(N)c(C#N)c42)C3)C1	InChI=1S/C30H37FN6O2/c1-18-13-36(14-18)27-23-16-39-30(8-6-19(2)21-4-5-24(33)22(12-32)26(21)30)11-25(23)34-28(35-27)38-17-29-7-3-9-37(29)15-20(31)10-29/h4-5,18-20H,3,6-11,13-17,33H2,1-2H3	WFWLDYHYZJKJIZ-UHFFFAOYSA-N	437028	US20260022132, Compound 658a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 5.90							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437028	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437028&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493826	439658657							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211867	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC(C)(O)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C30H37FN6O3/c1-18-6-8-30(25-20(18)4-5-23(33)21(25)12-32)11-24-22(14-40-30)26(36-15-28(2,38)16-36)35-27(34-24)39-17-29-7-3-9-37(29)13-19(31)10-29/h4-5,18-19,38H,3,6-11,13-17,33H2,1-2H3	KUGIYRGVFHLKIH-UHFFFAOYSA-N	437029	US20260022132, Compound 659a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 7.50							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437029	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437029&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134490069	439658658							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211868	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC[C@@H]5C[C@@H]54)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C31H37FN6O2/c1-18-5-8-31(27-21(18)3-4-24(34)22(27)14-33)13-25-23(16-40-31)28(38-10-6-19-11-26(19)38)36-29(35-25)39-17-30-7-2-9-37(30)15-20(32)12-30/h3-4,18-20,26H,2,5-13,15-17,34H2,1H3	IQYKUQMIVYPPOQ-UHFFFAOYSA-N	437030	US20260022132, Compound 660a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 2.80							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437030	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437030&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134490071	439658659							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211869	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC[C@H]5C[C@H]54)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C31H37FN6O2/c1-18-5-8-31(27-21(18)3-4-24(34)22(27)14-33)13-25-23(16-40-31)28(38-10-6-19-11-26(19)38)36-29(35-25)39-17-30-7-2-9-37(30)15-20(32)12-30/h3-4,18-20,26H,2,5-13,15-17,34H2,1H3	IQYKUQMIVYPPOQ-UHFFFAOYSA-N	437031	US20260022132, Compound 660b	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 3.30							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437031	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437031&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134490072	439658660							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211870	N#C[C@H]1CCN(c2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc3c2CO[C@@]2(CC[C@H](C)c4ccc(N)c(C#N)c42)C3)C1	InChI=1S/C31H36FN7O2/c1-19-5-8-31(27-22(19)3-4-25(35)23(27)14-34)12-26-24(17-41-31)28(38-10-6-20(13-33)15-38)37-29(36-26)40-18-30-7-2-9-39(30)16-21(32)11-30/h3-4,19-21H,2,5-12,15-18,35H2,1H3	MCVZLKKAOQTZQY-UHFFFAOYSA-N	437032	US20260022132, Compound 661a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 6.80							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437032	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437032&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134490073	439658661							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211871	N#C[C@@H]1CCN(c2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc3c2CO[C@@]2(CC[C@H](C)c4ccc(N)c(C#N)c42)C3)C1	InChI=1S/C31H36FN7O2/c1-19-5-8-31(27-22(19)3-4-25(35)23(27)14-34)12-26-24(17-41-31)28(38-10-6-20(13-33)15-38)37-29(36-26)40-18-30-7-2-9-39(30)16-21(32)11-30/h3-4,19-21H,2,5-12,15-18,35H2,1H3	MCVZLKKAOQTZQY-UHFFFAOYSA-N	437033	US20260022132, Compound 661b	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 3.50							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437033	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437033&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134490074	439658662							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211872	CO[C@@H]1CN2CCC[C@]2(COc2nc3c(c(N4CC[C@]45CCCOC5)n2)CO[C@@]2(CC[C@H](C)c4ccc(N)c(C#N)c42)C3)C1	InChI=1S/C34H44N6O4/c1-22-7-10-34(29-24(22)5-6-27(36)25(29)17-35)16-28-26(19-44-34)30(40-13-11-32(40)9-4-14-42-20-32)38-31(37-28)43-21-33-8-3-12-39(33)18-23(15-33)41-2/h5-6,22-23H,3-4,7-16,18-21,36H2,1-2H3	RNVKWRBVXPJAJZ-UHFFFAOYSA-N	437034	US20260022132, Compound 662a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 2.70							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437034	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437034&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134490075	439658663							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211873	CO[C@H]1CN2CCC[C@@]2(COc2nc3c(c(N4CC[C@]45CCCOC5)n2)CO[C@@]2(CC[C@H](C)c4ccc(N)c(C#N)c42)C3)C1	InChI=1S/C34H44N6O4/c1-22-7-10-34(29-24(22)5-6-27(36)25(29)17-35)16-28-26(19-44-34)30(40-13-11-32(40)9-4-14-42-20-32)38-31(37-28)43-21-33-8-3-12-39(33)18-23(15-33)41-2/h5-6,22-23H,3-4,7-16,18-21,36H2,1-2H3	RNVKWRBVXPJAJZ-UHFFFAOYSA-N	437035	US20260022132, Compound 662b	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			<2.50							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437035	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437035&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134490076	439658664							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211874	CO[C@@H]1CN2CCC[C@]2(COc2nc3c(c(N4CC[C@@]45CCCOC5)n2)CO[C@@]2(CC[C@H](C)c4ccc(N)c(C#N)c42)C3)C1	InChI=1S/C34H44N6O4/c1-22-7-10-34(29-24(22)5-6-27(36)25(29)17-35)16-28-26(19-44-34)30(40-13-11-32(40)9-4-14-42-20-32)38-31(37-28)43-21-33-8-3-12-39(33)18-23(15-33)41-2/h5-6,22-23H,3-4,7-16,18-21,36H2,1-2H3	RNVKWRBVXPJAJZ-UHFFFAOYSA-N	437036	US20260022132, Compound 662c	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 4.80							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437036	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437036&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134490077	439658665							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211875	CO[C@H]1CN2CCC[C@@]2(COc2nc3c(c(N4CC[C@@]45CCCOC5)n2)CO[C@@]2(CC[C@H](C)c4ccc(N)c(C#N)c42)C3)C1	InChI=1S/C34H44N6O4/c1-22-7-10-34(29-24(22)5-6-27(36)25(29)17-35)16-28-26(19-44-34)30(40-13-11-32(40)9-4-14-42-20-32)38-31(37-28)43-21-33-8-3-12-39(33)18-23(15-33)41-2/h5-6,22-23H,3-4,7-16,18-21,36H2,1-2H3	RNVKWRBVXPJAJZ-UHFFFAOYSA-N	437037	US20260022132, Compound 662d	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 3.50							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437037	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437037&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493853	439658666							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211876	N#Cc1c(N)ccc2c1[C@]1(CCC2)Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc([C@H]3CCOC3)c2CO1	InChI=1S/C29H34FN5O3/c30-20-11-28(7-2-9-35(28)14-20)17-37-27-33-24-12-29(38-16-22(24)26(34-27)19-6-10-36-15-19)8-1-3-18-4-5-23(32)21(13-31)25(18)29/h4-5,19-20H,1-3,6-12,14-17,32H2	GNLMLIKHAKZLAN-UHFFFAOYSA-N	437038	US20260022132, Compound 663a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 21.0							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437038	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437038&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134490079	439658667							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211877	N#Cc1c(N)ccc2c1[C@]1(CCC2)Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc([C@@H]3CCOC3)c2CO1	InChI=1S/C29H34FN5O3/c30-20-11-28(7-2-9-35(28)14-20)17-37-27-33-24-12-29(38-16-22(24)26(34-27)19-6-10-36-15-19)8-1-3-18-4-5-23(32)21(13-31)25(18)29/h4-5,19-20H,1-3,6-12,14-17,32H2	GNLMLIKHAKZLAN-UHFFFAOYSA-N	437039	US20260022132, Compound 663b	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 80.0							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437039	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437039&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134490080	439658668							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211878	N#Cc1c(N)ccc2c1[C@]1(CCC2)Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc([C@H]3CCCO3)c2CO1	InChI=1S/C29H34FN5O3/c30-19-12-28(8-3-10-35(28)15-19)17-37-27-33-23-13-29(38-16-21(23)26(34-27)24-5-2-11-36-24)9-1-4-18-6-7-22(32)20(14-31)25(18)29/h6-7,19,24H,1-5,8-13,15-17,32H2	VVULFPFQDPTCQF-UHFFFAOYSA-N	437040	US20260022132, Compound 664a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 10.00							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437040	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437040&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134490081	439658669							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211879	N#Cc1c(N)ccc2c1[C@]1(CCC2)Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc([C@@H]3CCCO3)c2CO1	InChI=1S/C29H34FN5O3/c30-19-12-28(8-3-10-35(28)15-19)17-37-27-33-23-13-29(38-16-21(23)26(34-27)24-5-2-11-36-24)9-1-4-18-6-7-22(32)20(14-31)25(18)29/h6-7,19,24H,1-5,8-13,15-17,32H2	VVULFPFQDPTCQF-UHFFFAOYSA-N	437041	US20260022132, Compound 664b	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 72.0							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437041	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437041&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134490082	439658670							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211880	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc([C@H]4CCCO4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C30H36FN5O3/c1-18-7-9-30(26-20(18)5-6-23(33)21(26)14-32)13-24-22(16-39-30)27(25-4-2-11-37-25)35-28(34-24)38-17-29-8-3-10-36(29)15-19(31)12-29/h5-6,18-19,25H,2-4,7-13,15-17,33H2,1H3	ISXVQBCKBHYBLS-UHFFFAOYSA-N	437042	US20260022132, Compound 665a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 3.10							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437042	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437042&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134490083	439658671							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211881	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc([C@@H]4CCCO4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C30H36FN5O3/c1-18-7-9-30(26-20(18)5-6-23(33)21(26)14-32)13-24-22(16-39-30)27(25-4-2-11-37-25)35-28(34-24)38-17-29-8-3-10-36(29)15-19(31)12-29/h5-6,18-19,25H,2-4,7-13,15-17,33H2,1H3	ISXVQBCKBHYBLS-UHFFFAOYSA-N	437043	US20260022132, Compound 665b	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 9.60							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437043	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437043&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134490084	439658672							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211882	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4CC(F)(F)C5)nc(N4CCC45COC5)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C31H36F2N6O3/c1-19-5-7-30(25-20(19)3-4-23(35)21(25)12-34)11-24-22(13-42-30)26(39-10-8-29(39)16-40-17-29)37-27(36-24)41-18-28-6-2-9-38(28)15-31(32,33)14-28/h3-4,19H,2,5-11,13-18,35H2,1H3	XDFIROPWACSWKD-UHFFFAOYSA-N	437044	US20260022132, Compound 666a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 5.90							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437044	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437044&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134490085	439658673							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211883	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC[C@@](C)(O)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C31H39FN6O3/c1-19-6-8-31(26-21(19)4-5-24(34)22(26)14-33)13-25-23(16-41-31)27(37-11-9-29(2,39)17-37)36-28(35-25)40-18-30-7-3-10-38(30)15-20(32)12-30/h4-5,19-20,39H,3,6-13,15-18,34H2,1-2H3	RHZYQPDOHSHFRI-UHFFFAOYSA-N	437045	US20260022132, Compound 667a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 45.0							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437045	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437045&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134490086	439658674							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211884	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC[C@](C)(O)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C31H39FN6O3/c1-19-6-8-31(26-21(19)4-5-24(34)22(26)14-33)13-25-23(16-41-31)27(37-11-9-29(2,39)17-37)36-28(35-25)40-18-30-7-3-10-38(30)15-20(32)12-30/h4-5,19-20,39H,3,6-13,15-18,34H2,1-2H3	RHZYQPDOHSHFRI-UHFFFAOYSA-N	437046	US20260022132, Compound 667b	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 13.0							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437046	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437046&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134490088	439658675							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211885	C[C@@H]1[C@@H](O)CN1c1nc(OC[C@@]23CCCN2C[C@H](F)C3)nc2c1CO[C@@]1(CC[C@H](C)c3ccc(N)c(C#N)c31)C2	InChI=1S/C30H37FN6O3/c1-17-6-8-30(26-20(17)4-5-23(33)21(26)12-32)11-24-22(15-40-30)27(37-14-25(38)18(37)2)35-28(34-24)39-16-29-7-3-9-36(29)13-19(31)10-29/h4-5,17-19,25,38H,3,6-11,13-16,33H2,1-2H3	HAZGXRJJHFSEGK-UHFFFAOYSA-N	437047	US20260022132, Compound 668a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			<2.50							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437047	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437047&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134490087	439658676							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211886	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4C[C@@H](O)[C@@H]4C)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C30H37FN6O3/c1-17-6-8-30(26-20(17)4-5-23(33)21(26)12-32)11-24-22(15-40-30)27(37-14-25(38)18(37)2)35-28(34-24)39-16-29-7-3-9-36(29)13-19(31)10-29/h4-5,17-19,25,38H,3,6-11,13-16,33H2,1-2H3	HAZGXRJJHFSEGK-UHFFFAOYSA-N	437048	US20260022132, Compound 668b	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 2.50							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437048	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437048&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134490090	439658677							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211887	C[C@@H]1[C@H](O)CN1c1nc(OC[C@@]23CCCN2C[C@H](F)C3)nc2c1CO[C@@]1(CC[C@H](C)c3ccc(N)c(C#N)c31)C2	InChI=1S/C30H37FN6O3/c1-17-6-8-30(26-20(17)4-5-23(33)21(26)12-32)11-24-22(15-40-30)27(37-14-25(38)18(37)2)35-28(34-24)39-16-29-7-3-9-36(29)13-19(31)10-29/h4-5,17-19,25,38H,3,6-11,13-16,33H2,1-2H3	HAZGXRJJHFSEGK-UHFFFAOYSA-N	437049	US20260022132, Compound 668c	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			<2.50							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437049	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437049&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134490089	439658678							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211888	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4C[C@H](O)[C@@H]4C)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C30H37FN6O3/c1-17-6-8-30(26-20(17)4-5-23(33)21(26)12-32)11-24-22(15-40-30)27(37-14-25(38)18(37)2)35-28(34-24)39-16-29-7-3-9-36(29)13-19(31)10-29/h4-5,17-19,25,38H,3,6-11,13-16,33H2,1-2H3	HAZGXRJJHFSEGK-UHFFFAOYSA-N	437050	US20260022132, Compound 668d	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 2.90							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437050	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437050&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134490091	439658679							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211889	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC(CCO)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C31H39FN6O3/c1-19-5-8-31(27-22(19)3-4-25(34)23(27)13-33)12-26-24(17-41-31)28(37-14-20(15-37)6-10-39)36-29(35-26)40-18-30-7-2-9-38(30)16-21(32)11-30/h3-4,19-21,39H,2,5-12,14-18,34H2,1H3	OEPJUTRWLIPJRE-UHFFFAOYSA-N	437051	US20260022132, Compound 669a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 21.0							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437051	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437051&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134490092	439658680							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211890	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC(O)(C(C)(C)C)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C33H43FN6O3/c1-20-8-10-32(27-22(20)6-7-25(36)23(27)14-35)13-26-24(16-43-32)28(39-17-33(41,18-39)30(2,3)4)38-29(37-26)42-19-31-9-5-11-40(31)15-21(34)12-31/h6-7,20-21,41H,5,8-13,15-19,36H2,1-4H3	LEBPRHNKANXUBX-UHFFFAOYSA-N	437052	US20260022132, Compound 670a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			>1000							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437052	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437052&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134490093	439658681							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211891	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC[C@@H]4C(C)(C)O)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H41FN6O3/c1-19-7-10-32(27-21(19)5-6-24(35)22(27)15-34)14-25-23(17-42-32)28(39-12-8-26(39)30(2,3)40)37-29(36-25)41-18-31-9-4-11-38(31)16-20(33)13-31/h5-6,19-20,26,40H,4,7-14,16-18,35H2,1-3H3	PIUVGUIJJUWTSQ-UHFFFAOYSA-N	437053	US20260022132, Compound 671a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 2.70							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437053	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437053&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134490094	439658682							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211892	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC[C@H]4C(C)(C)O)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H41FN6O3/c1-19-7-10-32(27-21(19)5-6-24(35)22(27)15-34)14-25-23(17-42-32)28(39-12-8-26(39)30(2,3)40)37-29(36-25)41-18-31-9-4-11-38(31)16-20(33)13-31/h5-6,19-20,26,40H,4,7-14,16-18,35H2,1-3H3	PIUVGUIJJUWTSQ-UHFFFAOYSA-N	437054	US20260022132, Compound 671b	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 3.00							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437054	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437054&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134490095	439658683							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211893	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC5(CCC(O)CC5)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C34H43FN6O3/c1-21-5-11-34(29-24(21)3-4-27(37)25(29)15-36)14-28-26(17-44-34)30(40-18-32(19-40)9-6-23(42)7-10-32)39-31(38-28)43-20-33-8-2-12-41(33)16-22(35)13-33/h3-4,21-23,42H,2,5-14,16-20,37H2,1H3	DYVRXMUNGMIXCZ-UHFFFAOYSA-N	437055	US20260022132, Compound 672a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 890							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437055	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437055&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134490096	439658684							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211894	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC[C@]45CC[C@@H](O)OC5)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C33H41FN6O4/c1-20-5-9-33(28-22(20)3-4-25(36)23(28)15-35)14-26-24(17-44-33)29(40-12-10-31(40)8-6-27(41)42-18-31)38-30(37-26)43-19-32-7-2-11-39(32)16-21(34)13-32/h3-4,20-21,27,41H,2,5-14,16-19,36H2,1H3	NGSLNXBNRYSEQS-UHFFFAOYSA-N	437056	US20260022132, Compound 673a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			<2.50							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437056	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437056&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134490097	439658685							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211895	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC(c5nccn5C)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C33H39FN8O2/c1-20-6-8-33(28-23(20)4-5-26(36)24(28)14-35)13-27-25(18-44-33)30(41-15-21(16-41)29-37-9-11-40(29)2)39-31(38-27)43-19-32-7-3-10-42(32)17-22(34)12-32/h4-5,9,11,20-22H,3,6-8,10,12-13,15-19,36H2,1-2H3	NTIFQLBRUDLBJP-UHFFFAOYSA-N	437057	US20260022132, Compound 674a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 51.0							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437057	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437057&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134490098	439658686							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211896	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC(c5cnn(C)c5)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C33H39FN8O2/c1-20-6-8-33(29-24(20)4-5-27(36)25(29)12-35)11-28-26(18-44-33)30(41-15-22(16-41)21-13-37-40(2)14-21)39-31(38-28)43-19-32-7-3-9-42(32)17-23(34)10-32/h4-5,13-14,20,22-23H,3,6-11,15-19,36H2,1-2H3	OARBUVORUZSPJB-UHFFFAOYSA-N	437058	US20260022132, Compound 675a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 6.30							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437058	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437058&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134490099	439658687							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211897	COCC1CC2(C1)CN(c1nc(OC[C@@]34CCCN3C[C@H](F)C4)nc3c1CO[C@@]1(CC[C@H](C)c4ccc(N)c(C#N)c41)C3)C2	InChI=1S/C34H43FN6O3/c1-21-6-8-34(29-24(21)4-5-27(37)25(29)14-36)13-28-26(17-44-34)30(40-18-32(19-40)10-22(11-32)16-42-2)39-31(38-28)43-20-33-7-3-9-41(33)15-23(35)12-33/h4-5,21-23H,3,6-13,15-20,37H2,1-2H3	JZOIFSKUQHLWGY-UHFFFAOYSA-N	437059	US20260022132, Compound 676a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 140							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437059	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437059&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134490100	439658688							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211898	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC(C)(CO)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C31H39FN6O3/c1-19-6-8-31(26-21(19)4-5-24(34)22(26)12-33)11-25-23(14-41-31)27(37-15-29(2,16-37)17-39)36-28(35-25)40-18-30-7-3-9-38(30)13-20(32)10-30/h4-5,19-20,39H,3,6-11,13-18,34H2,1-2H3	RADYTEUNECTYEZ-UHFFFAOYSA-N	437060	US20260022132, Compound 677a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 41.0							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437060	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437060&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134490101	439658689							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211899	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC5(CCOCC5)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C33H41FN6O3/c1-21-5-7-33(28-23(21)3-4-26(36)24(28)15-35)14-27-25(17-43-33)29(39-18-31(19-39)8-11-41-12-9-31)38-30(37-27)42-20-32-6-2-10-40(32)16-22(34)13-32/h3-4,21-22H,2,5-14,16-20,36H2,1H3	RWMCLNYUTUZALR-UHFFFAOYSA-N	437061	US20260022132, Compound 678a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 800							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437061	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437061&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134490102	439658690							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211900	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC5(CCCCO5)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C33H41FN6O3/c1-21-7-10-33(28-23(21)5-6-26(36)24(28)15-35)14-27-25(17-43-33)29(39-18-32(19-39)9-2-3-12-42-32)38-30(37-27)41-20-31-8-4-11-40(31)16-22(34)13-31/h5-6,21-22H,2-4,7-14,16-20,36H2,1H3	SWCJKDBUTIOJIX-UHFFFAOYSA-N	437062	US20260022132, Compound 679a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 160							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437062	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437062&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134490103	439658691							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211901	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4C[C@@H]5C[C@@H](CO)C[C@@H]54)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C33H41FN6O3/c1-19-5-7-33(29-23(19)3-4-26(36)24(29)13-35)12-27-25(17-43-33)30(40-14-21-9-20(16-41)10-28(21)40)38-31(37-27)42-18-32-6-2-8-39(32)15-22(34)11-32/h3-4,19-22,28,41H,2,5-12,14-18,36H2,1H3	XMPBJAMJAIXJNB-UHFFFAOYSA-N	437063	US20260022132, Compound 680a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 5.60							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437063	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437063&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134490104	439658692							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211902	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4C[C@@H]5C[C@@H](CO)C[C@@H]54)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C33H41FN6O3/c1-19-5-7-33(29-23(19)3-4-26(36)24(29)13-35)12-27-25(17-43-33)30(40-14-21-9-20(16-41)10-28(21)40)38-31(37-27)42-18-32-6-2-8-39(32)15-22(34)11-32/h3-4,19-22,28,41H,2,5-12,14-18,36H2,1H3	XMPBJAMJAIXJNB-UHFFFAOYSA-N	437064	US20260022132, Compound 680b	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 59.0							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437064	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437064&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134490105	439658693							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211903	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4C[C@H]5C[C@H](CO)C[C@H]54)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C33H41FN6O3/c1-19-5-7-33(29-23(19)3-4-26(36)24(29)13-35)12-27-25(17-43-33)30(40-14-21-9-20(16-41)10-28(21)40)38-31(37-27)42-18-32-6-2-8-39(32)15-22(34)11-32/h3-4,19-22,28,41H,2,5-12,14-18,36H2,1H3	XMPBJAMJAIXJNB-UHFFFAOYSA-N	437065	US20260022132, Compound 680c	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 3.30							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437065	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437065&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134490106	439658694							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211904	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4C[C@H]5OCC[C@H]54)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C31H37FN6O3/c1-18-5-8-31(27-20(18)3-4-23(34)21(27)13-33)12-24-22(16-41-31)28(38-15-26-25(38)6-10-39-26)36-29(35-24)40-17-30-7-2-9-37(30)14-19(32)11-30/h3-4,18-19,25-26H,2,5-12,14-17,34H2,1H3	PGAOJZVDGUIRGK-UHFFFAOYSA-N	437066	US20260022132, Compound 681a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 2.60							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437066	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437066&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134490107	439658695							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211905	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC5(CCN(C)C5=O)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C33H40FN7O3/c1-20-6-8-33(27-22(20)4-5-25(36)23(27)14-35)13-26-24(16-44-33)28(40-17-31(18-40)9-11-39(2)29(31)42)38-30(37-26)43-19-32-7-3-10-41(32)15-21(34)12-32/h4-5,20-21H,3,6-13,15-19,36H2,1-2H3	QNOPBTNFFKZDRE-UHFFFAOYSA-N	437067	US20260022132, Compound 682a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 25.0							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437067	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437067&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134490108	439658696							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211906	CC(C)CC1(O)CN(c2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc3c2CO[C@@]2(CC[C@H](C)c4ccc(N)c(C#N)c42)C3)C1	InChI=1S/C33H43FN6O3/c1-20(2)11-32(41)17-39(18-32)29-25-16-43-33(9-7-21(3)23-5-6-26(36)24(14-35)28(23)33)13-27(25)37-30(38-29)42-19-31-8-4-10-40(31)15-22(34)12-31/h5-6,20-22,41H,4,7-13,15-19,36H2,1-3H3	GLFORMZXSDATFM-UHFFFAOYSA-N	437068	US20260022132, Compound 683a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 26.0							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437068	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437068&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134490111	439658697							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211907	CCC1(O)CN(c2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc3c2CO[C@@]2(CC[C@H](C)c4ccc(N)c(C#N)c42)C3)C1	InChI=1S/C31H39FN6O3/c1-3-30(39)16-37(17-30)27-23-15-41-31(9-7-19(2)21-5-6-24(34)22(13-33)26(21)31)12-25(23)35-28(36-27)40-18-29-8-4-10-38(29)14-20(32)11-29/h5-6,19-20,39H,3-4,7-12,14-18,34H2,1-2H3	GIKNGOYZOZIOJW-UHFFFAOYSA-N	437069	US20260022132, Compound 684a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 39.0							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437069	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437069&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134490109	439658698							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211908	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4C5COCC4C5)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C31H37FN6O3/c1-18-5-7-31(27-22(18)3-4-25(34)23(27)12-33)11-26-24(16-41-31)28(38-20-9-21(38)15-39-14-20)36-29(35-26)40-17-30-6-2-8-37(30)13-19(32)10-30/h3-4,18-21H,2,5-11,13-17,34H2,1H3	ITBFBMMITFHNJQ-UHFFFAOYSA-N	437070	US20260022132, Compound 685a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 2.80							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437070	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437070&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134490112	439658699							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211909	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC(C)(CCO)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H41FN6O3/c1-20-6-8-32(27-22(20)4-5-25(35)23(27)14-34)13-26-24(16-42-32)28(38-17-30(2,18-38)9-11-40)37-29(36-26)41-19-31-7-3-10-39(31)15-21(33)12-31/h4-5,20-21,40H,3,6-13,15-19,35H2,1-2H3	KQDSBXUSZMYGFZ-UHFFFAOYSA-N	437071	US20260022132, Compound 686a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 34.0							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437071	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437071&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134490110	439658700							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211910	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC(c5cncn5C)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C33H39FN8O2/c1-20-6-8-33(29-23(20)4-5-26(36)24(29)12-35)11-27-25(17-44-33)30(41-14-21(15-41)28-13-37-19-40(28)2)39-31(38-27)43-18-32-7-3-9-42(32)16-22(34)10-32/h4-5,13,19-22H,3,6-11,14-18,36H2,1-2H3	FWPMVJQNZGKILH-UHFFFAOYSA-N	437073	US20260022132, Compound 687a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			<2.50							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437073	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437073&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134490115	439658702							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211911	COCC1CN(c2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc3c2CO[C@@]2(CC[C@H](C)c4ccc(N)c(C#N)c42)C3)C1(C)C	InChI=1S/C33H43FN6O3/c1-20-8-10-33(28-23(20)6-7-26(36)24(28)14-35)13-27-25(18-43-33)29(40-15-21(17-41-4)31(40,2)3)38-30(37-27)42-19-32-9-5-11-39(32)16-22(34)12-32/h6-7,20-22H,5,8-13,15-19,36H2,1-4H3	ILXODEODKSXZRR-UHFFFAOYSA-N	437074	US20260022132, Compound 688a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 3.60							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437074	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437074&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134490114	439658703							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211912	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4C[C@@H](CO)C4(C)C)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H41FN6O3/c1-19-7-9-32(27-22(19)5-6-25(35)23(27)13-34)12-26-24(17-42-32)28(39-14-20(16-40)30(39,2)3)37-29(36-26)41-18-31-8-4-10-38(31)15-21(33)11-31/h5-6,19-21,40H,4,7-12,14-18,35H2,1-3H3	RAZXEQVBCQQQTB-UHFFFAOYSA-N	437075	US20260022132, Compound 689a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			<2.50							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437075	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437075&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134490116	439658704							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211913	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4C[C@H](CO)C4(C)C)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H41FN6O3/c1-19-7-9-32(27-22(19)5-6-25(35)23(27)13-34)12-26-24(17-42-32)28(39-14-20(16-40)30(39,2)3)37-29(36-26)41-18-31-8-4-10-38(31)15-21(33)11-31/h5-6,19-21,40H,4,7-12,14-18,35H2,1-3H3	RAZXEQVBCQQQTB-UHFFFAOYSA-N	437076	US20260022132, Compound 689b	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 5.30							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437076	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437076&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134490120	439658705							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211914	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC(c5ccn(C)n5)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C33H39FN8O2/c1-20-6-9-33(29-23(20)4-5-26(36)24(29)14-35)13-28-25(18-44-33)30(41-15-21(16-41)27-7-11-40(2)39-27)38-31(37-28)43-19-32-8-3-10-42(32)17-22(34)12-32/h4-5,7,11,20-22H,3,6,8-10,12-13,15-19,36H2,1-2H3	UQPGBLZRMWBOOM-UHFFFAOYSA-N	437077	US20260022132, Compound 690a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 11.0							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437077	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437077&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134490118	439658706							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211915	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC(C(F)(F)CO)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C31H37F3N6O3/c1-18-5-7-30(26-21(18)3-4-24(36)22(26)11-35)10-25-23(15-43-30)27(39-12-19(13-39)31(33,34)16-41)38-28(37-25)42-17-29-6-2-8-40(29)14-20(32)9-29/h3-4,18-20,41H,2,5-10,12-17,36H2,1H3	PHTPNMRDEHLAOZ-UHFFFAOYSA-N	437078	US20260022132, Compound 691a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 48.0							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437078	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437078&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134490119	439658707							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211916	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC(C5CCOC5)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C33H41FN6O3/c1-20-5-8-33(29-24(20)3-4-27(36)25(29)13-35)12-28-26(18-43-33)30(39-14-22(15-39)21-6-10-41-17-21)38-31(37-28)42-19-32-7-2-9-40(32)16-23(34)11-32/h3-4,20-23H,2,5-12,14-19,36H2,1H3	TYVUMKRYXKTJFV-UHFFFAOYSA-N	437079	US20260022132, Compound 692a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 190							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437079	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437079&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134490121	439658708							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211917	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4C[C@H]5COCC[C@H]54)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H39FN6O3/c1-19-5-8-32(28-22(19)3-4-25(35)23(28)13-34)12-26-24(17-42-32)29(39-14-20-16-40-10-6-27(20)39)37-30(36-26)41-18-31-7-2-9-38(31)15-21(33)11-31/h3-4,19-21,27H,2,5-12,14-18,35H2,1H3	NHSXLCMBTSEHIC-UHFFFAOYSA-N	437080	US20260022132, Compound 693a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 5.80							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437080	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437080&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134490122	439658709							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211918	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC5(CC5F)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C31H36F2N6O2/c1-18-5-7-31(26-20(18)3-4-23(35)21(26)12-34)10-24-22(14-41-31)27(38-15-29(16-38)11-25(29)33)37-28(36-24)40-17-30-6-2-8-39(30)13-19(32)9-30/h3-4,18-19,25H,2,5-11,13-17,35H2,1H3	VKIMATKEOQARKR-UHFFFAOYSA-N	437081	US20260022132, Compound 694a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 22.0							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437081	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437081&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134490123	439658710							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211919	COC(C)(C)C1CCN1c1nc(OC[C@@]23CCCN2C[C@H](F)C3)nc2c1CO[C@@]1(CC[C@H](C)c3ccc(N)c(C#N)c31)C2	InChI=1S/C33H43FN6O3/c1-20-8-11-33(28-22(20)6-7-25(36)23(28)16-35)15-26-24(18-43-33)29(40-13-9-27(40)31(2,3)41-4)38-30(37-26)42-19-32-10-5-12-39(32)17-21(34)14-32/h6-7,20-21,27H,5,8-15,17-19,36H2,1-4H3	TZOISURSACEINO-UHFFFAOYSA-N	437083	US20260022132, Compound 695a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 8.70							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437083	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437083&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134490125	439658712							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211920	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC5(C4)OC[C@H]4C[C@H]45)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C33H39FN6O3/c1-19-5-7-32(28-22(19)3-4-26(36)23(28)12-35)11-27-24(15-43-32)29(39-16-33(17-39)25-9-20(25)14-42-33)38-30(37-27)41-18-31-6-2-8-40(31)13-21(34)10-31/h3-4,19-21,25H,2,5-11,13-18,36H2,1H3	MZPFSDIGYAWRSO-UHFFFAOYSA-N	437084	US20260022132, Compound 696a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 300							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437084	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437084&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134490126	439658713							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211921	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC(N5CCCOCC5)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C34H44FN7O3/c1-22-6-8-34(30-25(22)4-5-28(37)26(30)16-36)15-29-27(20-45-34)31(41-18-24(19-41)40-9-3-12-43-13-11-40)39-32(38-29)44-21-33-7-2-10-42(33)17-23(35)14-33/h4-5,22-24H,2-3,6-15,17-21,37H2,1H3	OJKGXIZJWUZOOJ-UHFFFAOYSA-N	437085	US20260022132, Compound 697a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			>1000							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437085	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437085&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134490127	439658714							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211922	CC1CCC2(CO1)CN(c1nc(OC[C@@]34CCCN3C[C@H](F)C4)nc3c1CO[C@@]1(CC[C@H](C)c4ccc(N)c(C#N)c41)C3)C2	InChI=1S/C34H43FN6O3/c1-21-6-10-34(29-24(21)4-5-27(37)25(29)14-36)13-28-26(16-44-34)30(40-17-32(18-40)9-7-22(2)42-19-32)39-31(38-28)43-20-33-8-3-11-41(33)15-23(35)12-33/h4-5,21-23H,3,6-13,15-20,37H2,1-2H3	KHVVWAUBOUQDPW-UHFFFAOYSA-N	437086	US20260022132, Compound 698a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 900							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437086	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437086&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134490128	439658715							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211923	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC(N5CCOCC5)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C33H42FN7O3/c1-21-5-7-33(29-24(21)3-4-27(36)25(29)15-35)14-28-26(19-44-33)30(40-17-23(18-40)39-9-11-42-12-10-39)38-31(37-28)43-20-32-6-2-8-41(32)16-22(34)13-32/h3-4,21-23H,2,5-14,16-20,36H2,1H3	ZPASFWWOUWZJSJ-UHFFFAOYSA-N	437087	US20260022132, Compound 699a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			>1000							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437087	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437087&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134490129	439658716							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211924	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC(C5CCO5)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H39FN6O3/c1-19-5-8-32(28-22(19)3-4-25(35)23(28)13-34)12-26-24(17-42-32)29(38-14-20(15-38)27-6-10-40-27)37-30(36-26)41-18-31-7-2-9-39(31)16-21(33)11-31/h3-4,19-21,27H,2,5-12,14-18,35H2,1H3	RGKCELPOEVMITC-UHFFFAOYSA-N	437088	US20260022132, Compound 700a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 59.0							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437088	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437088&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134490130	439658717							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211925	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC(F)(c5cccnc5)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C34H37F2N7O2/c1-21-7-9-34(29-24(21)5-6-27(38)25(29)14-37)13-28-26(17-45-34)30(42-18-33(36,19-42)22-4-2-10-39-15-22)41-31(40-28)44-20-32-8-3-11-43(32)16-23(35)12-32/h2,4-6,10,15,21,23H,3,7-9,11-13,16-20,38H2,1H3	PHFORYPWFYSLAN-UHFFFAOYSA-N	437089	US20260022132, Compound 701a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			<2.50							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437089	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437089&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134490131	439658718							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211926	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4C[C@@H](O)C4(C)C)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C31H39FN6O3/c1-18-7-9-31(26-20(18)5-6-23(34)21(26)13-33)12-24-22(16-41-31)27(38-15-25(39)29(38,2)3)36-28(35-24)40-17-30-8-4-10-37(30)14-19(32)11-30/h5-6,18-19,25,39H,4,7-12,14-17,34H2,1-3H3	BGLKGOQSWPMPNZ-UHFFFAOYSA-N	437090	US20260022132, Compound 702a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			<2.50							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437090	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437090&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134490132	439658719							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211927	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4C[C@H](O)C4(C)C)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C31H39FN6O3/c1-18-7-9-31(26-20(18)5-6-23(34)21(26)13-33)12-24-22(16-41-31)27(38-15-25(39)29(38,2)3)36-28(35-24)40-17-30-8-4-10-37(30)14-19(32)11-30/h5-6,18-19,25,39H,4,7-12,14-17,34H2,1-3H3	BGLKGOQSWPMPNZ-UHFFFAOYSA-N	437091	US20260022132, Compound 702b	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			<2.50							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437091	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437091&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134490133	439658720							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211928	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC(F)(CO)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C30H36F2N6O3/c1-18-5-7-30(25-20(18)3-4-23(34)21(25)11-33)10-24-22(13-41-30)26(37-14-28(32,15-37)16-39)36-27(35-24)40-17-29-6-2-8-38(29)12-19(31)9-29/h3-4,18-19,39H,2,5-10,12-17,34H2,1H3	SKTXEVMEZQMWJG-UHFFFAOYSA-N	437092	US20260022132, Compound 703a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 13.0							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437092	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437092&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134490134	439658721							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211929	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC5(CCC(C)(C)OC5)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C35H45FN6O3/c1-22-7-9-35(29-24(22)5-6-27(38)25(29)15-37)14-28-26(17-44-35)30(41-18-33(19-41)11-10-32(2,3)45-20-33)40-31(39-28)43-21-34-8-4-12-42(34)16-23(36)13-34/h5-6,22-23H,4,7-14,16-21,38H2,1-3H3	HAJXALSFHICKQI-UHFFFAOYSA-N	437093	US20260022132, Compound 704a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 470							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437093	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437093&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493952	439658722							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211930	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC(O)(c5cccc(F)c5)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C35H38F2N6O3/c1-21-8-10-35(30-25(21)6-7-28(39)26(30)15-38)14-29-27(17-46-35)31(42-18-34(44,19-42)22-4-2-5-23(36)12-22)41-32(40-29)45-20-33-9-3-11-43(33)16-24(37)13-33/h2,4-7,12,21,24,44H,3,8-11,13-14,16-20,39H2,1H3	SBFNRIMHFJJXAG-UHFFFAOYSA-N	437094	US20260022132, Compound 705a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 75.0							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437094	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437094&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134490136	439658723							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211931	N#Cc1c(N)ccc2c1[C@]1(CCC2)Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc([C@@H]3CCO3)c2CO1	InChI=1S/C28H32FN5O3/c29-18-11-27(7-2-9-34(27)14-18)16-36-26-32-22-12-28(37-15-20(22)25(33-26)23-6-10-35-23)8-1-3-17-4-5-21(31)19(13-30)24(17)28/h4-5,18,23H,1-3,6-12,14-16,31H2	KVASZMPUFFRBPX-UHFFFAOYSA-N	437095	US20260022132, Compound 706a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 100.0							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437095	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437095&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493930	439658724							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211932	N#Cc1c(N)ccc2c1[C@@]1(CCC2)Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc([C@@H]3CCO3)c2CO1	InChI=1S/C28H32FN5O3/c29-18-11-27(7-2-9-34(27)14-18)16-36-26-32-22-12-28(37-15-20(22)25(33-26)23-6-10-35-23)8-1-3-17-4-5-21(31)19(13-30)24(17)28/h4-5,18,23H,1-3,6-12,14-16,31H2	KVASZMPUFFRBPX-UHFFFAOYSA-N	437096	US20260022132, Compound 706b	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			>1000							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437096	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437096&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493917	439658725							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211933	N#Cc1c(N)ccc2c1[C@@]1(CCC2)Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc([C@H]3CCO3)c2CO1	InChI=1S/C28H32FN5O3/c29-18-11-27(7-2-9-34(27)14-18)16-36-26-32-22-12-28(37-15-20(22)25(33-26)23-6-10-35-23)8-1-3-17-4-5-21(31)19(13-30)24(17)28/h4-5,18,23H,1-3,6-12,14-16,31H2	KVASZMPUFFRBPX-UHFFFAOYSA-N	437097	US20260022132, Compound 706c	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			>1000							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437097	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437097&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493630	439658726							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211934	N#Cc1c(N)ccc2c1[C@]1(CCC2)Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc([C@H]3CCO3)c2CO1	InChI=1S/C28H32FN5O3/c29-18-11-27(7-2-9-34(27)14-18)16-36-26-32-22-12-28(37-15-20(22)25(33-26)23-6-10-35-23)8-1-3-17-4-5-21(31)19(13-30)24(17)28/h4-5,18,23H,1-3,6-12,14-16,31H2	KVASZMPUFFRBPX-UHFFFAOYSA-N	437098	US20260022132, Compound 706d	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 20.0							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437098	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437098&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493816	439658727							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211935	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC5(C4)CC(O)(C(F)F)C5)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C33H39F3N6O3/c1-19-5-7-33(26-21(19)3-4-24(38)22(26)11-37)10-25-23(13-45-33)27(41-16-30(17-41)14-32(43,15-30)28(35)36)40-29(39-25)44-18-31-6-2-8-42(31)12-20(34)9-31/h3-4,19-20,28,43H,2,5-10,12-18,38H2,1H3	NFIXLLBEZQDXND-UHFFFAOYSA-N	437099	US20260022132, Compound 707a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 470							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437099	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437099&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493953	439658728							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211936	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC(O)(c5ccc(F)cc5)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C35H38F2N6O3/c1-21-9-11-35(30-25(21)7-8-28(39)26(30)15-38)14-29-27(17-46-35)31(42-18-34(44,19-42)22-3-5-23(36)6-4-22)41-32(40-29)45-20-33-10-2-12-43(33)16-24(37)13-33/h3-8,21,24,44H,2,9-14,16-20,39H2,1H3	KTEMIAYQLJBCHP-UHFFFAOYSA-N	437100	US20260022132, Compound 708a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 89.0							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437100	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437100&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493914	439658729							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211937	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC(Oc5ccncc5)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C34H38FN7O3/c1-21-5-9-34(30-25(21)3-4-28(37)26(30)15-36)14-29-27(19-44-34)31(41-17-24(18-41)45-23-6-10-38-11-7-23)40-32(39-29)43-20-33-8-2-12-42(33)16-22(35)13-33/h3-4,6-7,10-11,21-22,24H,2,5,8-9,12-14,16-20,37H2,1H3	NGEMLPCTDKTGJQ-UHFFFAOYSA-N	437101	US20260022132, Compound 709a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			<2.50							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437101	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437101&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493815	439658730							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211938	Cc1cc(C)n(C2CN(c3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc4c3CO[C@@]3(CC[C@H](C)c5ccc(N)c(C#N)c53)C4)C2)n1	InChI=1S/C34H41FN8O2/c1-20-7-9-34(30-25(20)5-6-28(37)26(30)14-36)13-29-27(18-45-34)31(41-16-24(17-41)43-22(3)11-21(2)40-43)39-32(38-29)44-19-33-8-4-10-42(33)15-23(35)12-33/h5-6,11,20,23-24H,4,7-10,12-13,15-19,37H2,1-3H3	RVXYFLMJCDLIAI-UHFFFAOYSA-N	437102	US20260022132, Compound 710a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 190							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437102	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437102&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493789	439658731							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211939	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC(C)(N5CCOCC5)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C34H44FN7O3/c1-22-6-8-34(29-24(22)4-5-27(37)25(29)16-36)15-28-26(18-45-34)30(40-19-32(2,20-40)41-10-12-43-13-11-41)39-31(38-28)44-21-33-7-3-9-42(33)17-23(35)14-33/h4-5,22-23H,3,6-15,17-21,37H2,1-2H3	SYSYCIUWGSOCOF-UHFFFAOYSA-N	437103	US20260022132, Compound 711a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			>1000							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437103	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437103&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493629	439658732							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211940	CC1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC(n5cnc6c5CCCC6)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C36H43FN8O2/c1-22-9-11-36(32-25(22)7-8-28(39)26(32)15-38)14-30-27(19-47-36)33(43-17-24(18-43)45-21-40-29-5-2-3-6-31(29)45)42-34(41-30)46-20-35-10-4-12-44(35)16-23(37)13-35/h7-8,21-24H,2-6,9-14,16-20,39H2,1H3	JEQQGCQAPBCHAG-UHFFFAOYSA-N	437104	US20260022132, Compound 712a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 28.0							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437104	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437104&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134494079	439658733							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211941	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC(Oc5ccccn5)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C34H38FN7O3/c1-21-8-10-34(30-24(21)6-7-27(37)25(30)15-36)14-28-26(19-44-34)31(41-17-23(18-41)45-29-5-2-3-11-38-29)40-32(39-28)43-20-33-9-4-12-42(33)16-22(35)13-33/h2-3,5-7,11,21-23H,4,8-10,12-14,16-20,37H2,1H3	KTKPAFCOQQYOOI-UHFFFAOYSA-N	437105	US20260022132, Compound 713a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 4.50							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437105	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437105&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134494090	439658734							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211942	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC(N5CCCC5=O)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C33H40FN7O3/c1-20-7-9-33(29-23(20)5-6-26(36)24(29)14-35)13-27-25(18-44-33)30(39-16-22(17-39)41-11-2-4-28(41)42)38-31(37-27)43-19-32-8-3-10-40(32)15-21(34)12-32/h5-6,20-22H,2-4,7-13,15-19,36H2,1H3	ZDLLFFUSCZWRNE-UHFFFAOYSA-N	437106	US20260022132, Compound 714a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 22.0							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437106	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437106&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493947	439658735							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211943	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC(CO)(C5CC5)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C33H41FN6O3/c1-20-7-9-33(28-23(20)5-6-26(36)24(28)13-35)12-27-25(15-43-33)29(39-16-31(17-39,18-41)21-3-4-21)38-30(37-27)42-19-32-8-2-10-40(32)14-22(34)11-32/h5-6,20-22,41H,2-4,7-12,14-19,36H2,1H3	VTGQCTKQSCGGLZ-UHFFFAOYSA-N	437107	US20260022132, Compound 715a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 120							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437107	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437107&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493639	439658736							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211944	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC(CN5CCOCC5)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C34H44FN7O3/c1-22-5-7-34(30-25(22)3-4-28(37)26(30)15-36)14-29-27(20-45-34)31(41-17-23(18-41)16-40-9-11-43-12-10-40)39-32(38-29)44-21-33-6-2-8-42(33)19-24(35)13-33/h3-4,22-24H,2,5-14,16-21,37H2,1H3	SHKGJMDQKYXTST-UHFFFAOYSA-N	437108	US20260022132, Compound 716a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 16.0							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437108	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437108&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493818	439658737							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211945	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC5(CC(C(C)(C)O)C5)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C35H45FN6O3/c1-21-7-9-35(29-24(21)5-6-27(38)25(29)15-37)14-28-26(17-45-35)30(41-18-33(19-41)11-22(12-33)32(2,3)43)40-31(39-28)44-20-34-8-4-10-42(34)16-23(36)13-34/h5-6,21-23,43H,4,7-14,16-20,38H2,1-3H3	VWNGBVVDDGRQKF-UHFFFAOYSA-N	437109	US20260022132, Compound 717a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 180							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437109	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437109&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493957	439658738							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211946	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC(C5COC5)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H39FN6O3/c1-19-5-7-32(28-23(19)3-4-26(35)24(28)11-34)10-27-25(17-42-32)29(38-12-20(13-38)21-15-40-16-21)37-30(36-27)41-18-31-6-2-8-39(31)14-22(33)9-31/h3-4,19-22H,2,5-10,12-18,35H2,1H3	VWTXOWOUCZCJLH-UHFFFAOYSA-N	437110	US20260022132, Compound 718a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 64.0							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437110	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437110&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493637	439658739							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211947	COC1(C)CN(c2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc3c2CO[C@@]2(CC[C@H](C)c4ccc(N)c(C#N)c42)C3)C1	InChI=1S/C31H39FN6O3/c1-19-7-9-31(26-21(19)5-6-24(34)22(26)13-33)12-25-23(15-41-31)27(37-16-29(2,17-37)39-3)36-28(35-25)40-18-30-8-4-10-38(30)14-20(32)11-30/h5-6,19-20H,4,7-12,14-18,34H2,1-3H3	RLFIQODEAFQUKL-UHFFFAOYSA-N	437111	US20260022132, Compound 719a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 160							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437111	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437111&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134494086	439658740							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211948	COC1CC2(CCN2c2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc3c2CO[C@@]2(CC[C@H](C)c4ccc(N)c(C#N)c42)C3)C1	InChI=1S/C33H41FN6O3/c1-20-6-8-33(28-23(20)4-5-26(36)24(28)16-35)15-27-25(18-43-33)29(40-11-9-31(40)13-22(14-31)41-2)38-30(37-27)42-19-32-7-3-10-39(32)17-21(34)12-32/h4-5,20-22H,3,6-15,17-19,36H2,1-2H3	WNBWJVWQXGXYQW-UHFFFAOYSA-N	437112	US20260022132, Compound 720a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 2.50							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437112	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437112&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493926	439658741							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211949	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCC45CC(F)C5)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H38F2N6O2/c1-19-5-7-32(27-22(19)3-4-25(36)23(27)15-35)14-26-24(17-42-32)28(40-10-8-30(40)11-20(33)12-30)38-29(37-26)41-18-31-6-2-9-39(31)16-21(34)13-31/h3-4,19-21H,2,5-14,16-18,36H2,1H3	XGLLOWWUZHKVNQ-UHFFFAOYSA-N	437113	US20260022132, Compound 721a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			<2.50							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437113	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437113&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134494082	439658742							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211950	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC(C(N)=O)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C30H36FN7O3/c1-17-5-7-30(25-20(17)3-4-23(33)21(25)11-32)10-24-22(15-41-30)27(37-12-18(13-37)26(34)39)36-28(35-24)40-16-29-6-2-8-38(29)14-19(31)9-29/h3-4,17-19H,2,5-10,12-16,33H2,1H3,(H2,34,39)	LURFLURQZWBKQI-UHFFFAOYSA-N	437114	US20260022132, Compound 722a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 4.50							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437114	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437114&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493919	439658743							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211951	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC5(CCC5O)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H39FN6O3/c1-19-5-9-32(27-21(19)3-4-24(35)22(27)13-34)12-25-23(15-42-32)28(38-16-30(17-38)8-6-26(30)40)37-29(36-25)41-18-31-7-2-10-39(31)14-20(33)11-31/h3-4,19-20,26,40H,2,5-12,14-18,35H2,1H3	SPLCFDYUUMJXKH-UHFFFAOYSA-N	437115	US20260022132, Compound 723a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 180							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437115	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437115&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493928	439658744							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211952	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC5(CC(F)C5)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H38F2N6O2/c1-19-5-7-32(27-22(19)3-4-25(36)23(27)13-35)12-26-24(15-42-32)28(39-16-30(17-39)9-20(33)10-30)38-29(37-26)41-18-31-6-2-8-40(31)14-21(34)11-31/h3-4,19-21H,2,5-12,14-18,36H2,1H3	LYLLGRPNHKUIPR-UHFFFAOYSA-N	437116	US20260022132, Compound 724a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 130							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437116	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437116&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493958	439658745							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211953	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC(C56CC(O)(C5)C6)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C34H41FN6O3/c1-20-5-7-34(28-23(20)3-4-26(37)24(28)11-36)10-27-25(15-44-34)29(40-12-21(13-40)31-16-33(42,17-31)18-31)39-30(38-27)43-19-32-6-2-8-41(32)14-22(35)9-32/h3-4,20-22,42H,2,5-10,12-19,37H2,1H3	CJMYECRWFZQTQZ-UHFFFAOYSA-N	437117	US20260022132, Compound 725a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 380							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437117	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437117&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493934	439658746							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211954	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC5(CCC5C#N)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C33H38FN7O2/c1-20-5-9-33(28-23(20)3-4-26(37)24(28)14-36)12-27-25(16-43-33)29(40-17-31(18-40)8-6-21(31)13-35)39-30(38-27)42-19-32-7-2-10-41(32)15-22(34)11-32/h3-4,20-22H,2,5-12,15-19,37H2,1H3	WCCXVGMXYIWTDI-UHFFFAOYSA-N	437118	US20260022132, Compound 726a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 34.0							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437118	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437118&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493855	439658747							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211955	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC5(CCCCOC5)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C34H43FN6O3/c1-22-7-10-34(29-24(22)5-6-27(37)25(29)15-36)14-28-26(17-44-34)30(40-18-32(19-40)8-2-3-12-42-20-32)39-31(38-28)43-21-33-9-4-11-41(33)16-23(35)13-33/h5-6,22-23H,2-4,7-14,16-21,37H2,1H3	MLDUARNWPALILR-UHFFFAOYSA-N	437119	US20260022132, Compound 727a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 240							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437119	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437119&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134494097	439658748							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211956	CCOC1(C)CN(c2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc3c2CO[C@@]2(CC[C@H](C)c4ccc(N)c(C#N)c42)C3)C1	InChI=1S/C32H41FN6O3/c1-4-41-30(3)17-38(18-30)28-24-16-42-32(10-8-20(2)22-6-7-25(35)23(14-34)27(22)32)13-26(24)36-29(37-28)40-19-31-9-5-11-39(31)15-21(33)12-31/h6-7,20-21H,4-5,8-13,15-19,35H2,1-3H3	JZZWUUPRCSOSDQ-UHFFFAOYSA-N	437120	US20260022132, Compound 728a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 280							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437120	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437120&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134494104	439658749							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211957	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4[C@@H]5C[C@H](O)C[C@H]4C5)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H39FN6O3/c1-18-5-7-32(28-23(18)3-4-26(35)24(28)14-34)13-27-25(16-42-32)29(39-20-9-21(39)11-22(40)10-20)37-30(36-27)41-17-31-6-2-8-38(31)15-19(33)12-31/h3-4,18-22,40H,2,5-13,15-17,35H2,1H3	LVTOPZCOFMBCJX-UHFFFAOYSA-N	437121	US20260022132, Compound 729a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 3.20							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437121	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437121&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493938	439658750							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211958	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4[C@@H]5C[C@@H](O)C[C@H]4C5)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H39FN6O3/c1-18-5-7-32(28-23(18)3-4-26(35)24(28)14-34)13-27-25(16-42-32)29(39-20-9-21(39)11-22(40)10-20)37-30(36-27)41-17-31-6-2-8-38(31)15-19(33)12-31/h3-4,18-22,40H,2,5-13,15-17,35H2,1H3	LVTOPZCOFMBCJX-UHFFFAOYSA-N	437122	US20260022132, Compound 729b	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 5.20							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437122	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437122&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493829	439658751							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211959	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4CC(F)C5)nc(N4CC(C#N)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C30H34FN7O2/c1-18-5-7-30(26-21(18)3-4-24(34)22(26)12-33)10-25-23(16-40-30)27(37-13-19(11-32)14-37)36-28(35-25)39-17-29-6-2-8-38(29)15-20(31)9-29/h3-4,18-20H,2,5-10,13-17,34H2,1H3	NHSJNKDVVDRUFQ-UHFFFAOYSA-N	437123	US20260022132, Compound 730a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 3.10							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437123	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437123&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134494103	439658752							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211960	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC5(CN(C)C(=O)C5(F)F)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C33H38F3N7O3/c1-19-6-8-32(26-21(19)4-5-24(38)22(26)12-37)11-25-23(14-46-32)27(42-16-30(17-42)15-41(2)28(44)33(30,35)36)40-29(39-25)45-18-31-7-3-9-43(31)13-20(34)10-31/h4-5,19-20H,3,6-11,13-18,38H2,1-2H3	IGHWUMYBADVSCN-UHFFFAOYSA-N	437124	US20260022132, Compound 731a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 4.80							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437124	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437124&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493636	439658753							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211961	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC(F)(c5nccn5C)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C33H38F2N8O2/c1-20-6-8-33(27-22(20)4-5-25(37)23(27)14-36)13-26-24(16-45-33)28(42-17-32(35,18-42)29-38-9-11-41(29)2)40-30(39-26)44-19-31-7-3-10-43(31)15-21(34)12-31/h4-5,9,11,20-21H,3,6-8,10,12-13,15-19,37H2,1-2H3	KHWBFKKWNJWPTJ-UHFFFAOYSA-N	437125	US20260022132, Compound 732a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 120							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437125	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437125&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493854	439658754							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211962	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC(F)(C#N)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C30H33F2N7O2/c1-18-5-7-30(25-20(18)3-4-23(35)21(25)11-33)10-24-22(13-41-30)26(38-15-28(32,14-34)16-38)37-27(36-24)40-17-29-6-2-8-39(29)12-19(31)9-29/h3-4,18-19H,2,5-10,12-13,15-17,35H2,1H3	UIFCSNBLNGOACW-UHFFFAOYSA-N	437126	US20260022132, Compound 733a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 21.0							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437126	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437126&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493640	439658755							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211963	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC(F)(C(N)=O)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C30H35F2N7O3/c1-17-5-7-30(24-19(17)3-4-22(34)20(24)11-33)10-23-21(13-42-30)25(38-14-29(32,15-38)26(35)40)37-27(36-23)41-16-28-6-2-8-39(28)12-18(31)9-28/h3-4,17-18H,2,5-10,12-16,34H2,1H3,(H2,35,40)	FHAKTJZOGXRLDM-UHFFFAOYSA-N	437127	US20260022132, Compound 734a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 5.30							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437127	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437127&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493909	439658756							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211964	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC(N5CC[C@@H](O)C5)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C33H42FN7O3/c1-20-5-8-33(29-24(20)3-4-27(36)25(29)13-35)12-28-26(18-44-33)30(40-15-22(16-40)39-10-6-23(42)17-39)38-31(37-28)43-19-32-7-2-9-41(32)14-21(34)11-32/h3-4,20-23,42H,2,5-12,14-19,36H2,1H3	DTOJLIMVXDZVMH-UHFFFAOYSA-N	437128	US20260022132, Compound 735a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 680							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437128	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437128&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493840	439658757							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211965	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCC4CCC#N)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H38FN7O2/c1-20-7-10-32(28-23(20)5-6-26(36)24(28)16-35)15-27-25(18-42-32)29(40-13-8-22(40)4-2-11-34)38-30(37-27)41-19-31-9-3-12-39(31)17-21(33)14-31/h5-6,20-22H,2-4,7-10,12-15,17-19,36H2,1H3	ZLVMOSJEWOWJFO-UHFFFAOYSA-N	437129	US20260022132, Compound 736a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			<2.50							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437129	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437129&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493632	439658758							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211966	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCC45CC(CO)C5)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C33H41FN6O3/c1-20-5-7-33(28-23(20)3-4-26(36)24(28)15-35)14-27-25(18-43-33)29(40-10-8-31(40)11-21(12-31)17-41)38-30(37-27)42-19-32-6-2-9-39(32)16-22(34)13-32/h3-4,20-22,41H,2,5-14,16-19,36H2,1H3	ZYYGMFCRYVBUQH-UHFFFAOYSA-N	437130	US20260022132, Compound 737a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 3.00							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437130	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437130&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493644	439658759							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211967	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC(Cc5cnn(C)c5)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C34H41FN8O2/c1-21-6-8-34(30-25(21)4-5-28(37)26(30)13-36)12-29-27(19-45-34)31(42-16-23(17-42)10-22-14-38-41(2)15-22)40-32(39-29)44-20-33-7-3-9-43(33)18-24(35)11-33/h4-5,14-15,21,23-24H,3,6-12,16-20,37H2,1-2H3	MWIPWQOFDPRIGP-UHFFFAOYSA-N	437131	US20260022132, Compound 738a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 8.10							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437131	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437131&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493810	439658760							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211968	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC(C5(O)CCC5)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C33H41FN6O3/c1-20-6-10-33(28-23(20)4-5-26(36)24(28)14-35)13-27-25(18-43-33)29(39-15-21(16-39)32(41)8-2-9-32)38-30(37-27)42-19-31-7-3-11-40(31)17-22(34)12-31/h4-5,20-22,41H,2-3,6-13,15-19,36H2,1H3	UTPJIUVRYNRTCU-UHFFFAOYSA-N	437132	US20260022132, Compound 739a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 330							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437132	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437132&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493932	439658761							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211969	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC(OC5COC5)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H39FN6O4/c1-19-5-7-32(28-23(19)3-4-26(35)24(28)11-34)10-27-25(17-42-32)29(38-13-21(14-38)43-22-15-40-16-22)37-30(36-27)41-18-31-6-2-8-39(31)12-20(33)9-31/h3-4,19-22H,2,5-10,12-18,35H2,1H3	CCJDWGBMHYHVFP-UHFFFAOYSA-N	437133	US20260022132, Compound 740a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 11.0							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437133	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437133&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493860	439658762							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211970	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC[C@H]4CCO)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C31H39FN6O3/c1-19-5-9-31(27-22(19)3-4-25(34)23(27)15-33)14-26-24(17-41-31)28(38-11-6-21(38)7-12-39)36-29(35-26)40-18-30-8-2-10-37(30)16-20(32)13-30/h3-4,19-21,39H,2,5-14,16-18,34H2,1H3	ARBVWVRPIMHVPL-UHFFFAOYSA-N	437134	US20260022132, Compound 741a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			<2.50							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437134	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437134&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493959	439658763							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211971	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC[C@@H]4CCO)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C31H39FN6O3/c1-19-5-9-31(27-22(19)3-4-25(34)23(27)15-33)14-26-24(17-41-31)28(38-11-6-21(38)7-12-39)36-29(35-26)40-18-30-8-2-10-37(30)16-20(32)13-30/h3-4,19-21,39H,2,5-14,16-18,34H2,1H3	ARBVWVRPIMHVPL-UHFFFAOYSA-N	437135	US20260022132, Compound 741b	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 3.30							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437135	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437135&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493635	439658764							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211972	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC(CCC#N)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H38FN7O2/c1-20-7-9-32(28-23(20)5-6-26(36)24(28)14-35)13-27-25(18-42-32)29(39-15-21(16-39)4-2-10-34)38-30(37-27)41-19-31-8-3-11-40(31)17-22(33)12-31/h5-6,20-22H,2-4,7-9,11-13,15-19,36H2,1H3	PBWAIOOZXHTWHX-UHFFFAOYSA-N	437136	US20260022132, Compound 742a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 24.0							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437136	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437136&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134494095	439658765							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211973	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC(C(C)(C)O)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H41FN6O3/c1-19-7-9-32(27-22(19)5-6-25(35)23(27)13-34)12-26-24(17-42-32)28(38-14-20(15-38)30(2,3)40)37-29(36-26)41-18-31-8-4-10-39(31)16-21(33)11-31/h5-6,19-21,40H,4,7-12,14-18,35H2,1-3H3	WSLXZJKHYQVJBP-UHFFFAOYSA-N	437137	US20260022132, Compound 743a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			>1000							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437137	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437137&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493945	439658766							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211974	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC(C5(O)CC5)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H39FN6O3/c1-19-5-7-32(27-22(19)3-4-25(35)23(27)13-34)12-26-24(17-42-32)28(38-14-20(15-38)31(40)8-9-31)37-29(36-26)41-18-30-6-2-10-39(30)16-21(33)11-30/h3-4,19-21,40H,2,5-12,14-18,35H2,1H3	OYTWZJSVLGGUFO-UHFFFAOYSA-N	437138	US20260022132, Compound 744a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 28.0							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437138	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437138&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134494106	439658767							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211975	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC([C@@H](C)O)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C31H39FN6O3/c1-18-6-8-31(27-22(18)4-5-25(34)23(27)12-33)11-26-24(16-41-31)28(37-13-20(14-37)19(2)39)36-29(35-26)40-17-30-7-3-9-38(30)15-21(32)10-30/h4-5,18-21,39H,3,6-11,13-17,34H2,1-2H3	WCRAATVQWLEXOF-UHFFFAOYSA-N	437139	US20260022132, Compound 745a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 43.0							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437139	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437139&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493641	439658768							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211976	C[C@H](O)C1CN(c2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc3c2CO[C@@]2(CC[C@H](C)c4ccc(N)c(C#N)c42)C3)C1	InChI=1S/C31H39FN6O3/c1-18-6-8-31(27-22(18)4-5-25(34)23(27)12-33)11-26-24(16-41-31)28(37-13-20(14-37)19(2)39)36-29(35-26)40-17-30-7-3-9-38(30)15-21(32)10-30/h4-5,18-21,39H,3,6-11,13-17,34H2,1-2H3	WCRAATVQWLEXOF-UHFFFAOYSA-N	437140	US20260022132, Compound 745b	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 100.0							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437140	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437140&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493861	439658769							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211977	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC(CC#N)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C31H36FN7O2/c1-19-5-8-31(27-22(19)3-4-25(35)23(27)13-34)12-26-24(17-41-31)28(38-14-20(15-38)6-9-33)37-29(36-26)40-18-30-7-2-10-39(30)16-21(32)11-30/h3-4,19-21H,2,5-8,10-12,14-18,35H2,1H3	JWFLHPJZEBYSOV-UHFFFAOYSA-N	437141	US20260022132, Compound 746a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 11.0							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437141	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437141&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493939	439658770							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211978	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC[C@]45C[C@@H](O)C5)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H39FN6O3/c1-19-5-7-32(27-22(19)3-4-25(35)23(27)15-34)14-26-24(17-42-32)28(39-10-8-30(39)12-21(40)13-30)37-29(36-26)41-18-31-6-2-9-38(31)16-20(33)11-31/h3-4,19-21,40H,2,5-14,16-18,35H2,1H3	PRTVPVSGMHPKLJ-UHFFFAOYSA-N	437142	US20260022132, Compound 747a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			<2.50							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437142	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437142&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493964	439658771							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211979	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCC45CC(O)C5)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H39FN6O3/c1-19-5-7-32(27-22(19)3-4-25(35)23(27)15-34)14-26-24(17-42-32)28(39-10-8-30(39)12-21(40)13-30)37-29(36-26)41-18-31-6-2-9-38(31)16-20(33)11-31/h3-4,19-21,40H,2,5-14,16-18,35H2,1H3	PRTVPVSGMHPKLJ-UHFFFAOYSA-N	437143	US20260022132, Compound 747b	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			<2.50							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437143	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437143&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134494110	439658772							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211980	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC(n5cccn5)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H37FN8O2/c1-20-6-8-32(28-23(20)4-5-26(35)24(28)14-34)13-27-25(18-43-32)29(39-16-22(17-39)41-11-3-9-36-41)38-30(37-27)42-19-31-7-2-10-40(31)15-21(33)12-31/h3-5,9,11,20-22H,2,6-8,10,12-13,15-19,35H2,1H3	BQXHHGVZKFNJAP-UHFFFAOYSA-N	437144	US20260022132, Compound 748a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 15.0							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437144	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437144&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493941	439658773							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211981	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC(F)(CC#N)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C31H35F2N7O2/c1-19-5-7-31(26-21(19)3-4-24(36)22(26)13-35)12-25-23(15-42-31)27(39-16-29(33,17-39)8-9-34)38-28(37-25)41-18-30-6-2-10-40(30)14-20(32)11-30/h3-4,19-20H,2,5-8,10-12,14-18,36H2,1H3	LUPWLXOBPYQFGM-UHFFFAOYSA-N	437145	US20260022132, Compound 749a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 16.0							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437145	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437145&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493827	439658774							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211982	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC(n5ccnc5)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H37FN8O2/c1-20-5-7-32(28-23(20)3-4-26(35)24(28)13-34)12-27-25(17-43-32)29(40-15-22(16-40)39-10-8-36-19-39)38-30(37-27)42-18-31-6-2-9-41(31)14-21(33)11-31/h3-4,8,10,19-22H,2,5-7,9,11-12,14-18,35H2,1H3	MDPVZAZVSZRZJO-UHFFFAOYSA-N	437146	US20260022132, Compound 750a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			<2.50							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437146	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437146&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493647	439658775							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211983	N#Cc1c(N)ccc2c1[C@]1(CCC2)Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc(N3CC[C@@H]3CO)c2CO1	InChI=1S/C29H35FN6O3/c30-19-11-28(7-2-9-35(28)14-19)17-38-27-33-24-12-29(8-1-3-18-4-5-23(32)21(13-31)25(18)29)39-16-22(24)26(34-27)36-10-6-20(36)15-37/h4-5,19-20,37H,1-3,6-12,14-17,32H2	BDPDXXCXPPFHGP-UHFFFAOYSA-N	437147	(S)-7-amino-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-4'-((R)-2-(hydroxymethyl)azetidin-1-yl)-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidine]-8-carbonitrile ::US20260022132, Compound 751a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			<2.50							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437147	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437147&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493962	439658776							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211984	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC5(CN(C)CCO5)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C33H42FN7O3/c1-21-6-8-33(28-23(21)4-5-26(36)24(28)14-35)13-27-25(16-44-33)29(40-18-32(19-40)17-39(2)10-11-43-32)38-30(37-27)42-20-31-7-3-9-41(31)15-22(34)12-31/h4-5,21-22H,3,6-13,15-20,36H2,1-2H3	TYVQDYPNZUUTDZ-UHFFFAOYSA-N	437148	US20260022132, Compound 752a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 180							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437148	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437148&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493832	439658777							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211985	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC(O)C45CCC5)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H39FN6O3/c1-19-6-10-32(27-21(19)4-5-24(35)22(27)14-34)13-25-23(17-42-32)28(39-16-26(40)31(39)8-2-9-31)37-29(36-25)41-18-30-7-3-11-38(30)15-20(33)12-30/h4-5,19-20,26,40H,2-3,6-13,15-18,35H2,1H3	AEKKZDRXZWGXLU-UHFFFAOYSA-N	437149	US20260022132, Compound 753a	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 16.0							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437149	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437149&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493820	439658778							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211986	CC1CCC2(Cc3nc(OCC45CCCN4CC(F)C5)nc(N4CC(OC5CC5)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H39FN6O3/c1-19-7-9-32(28-23(19)5-6-26(35)24(28)13-34)12-27-25(17-41-32)29(38-15-22(16-38)42-21-3-4-21)37-30(36-27)40-18-31-8-2-10-39(31)14-20(33)11-31/h5-6,19-22H,2-4,7-12,14-18,35H2,1H3	JHUGBHLFEKUJIY-UHFFFAOYSA-N	437150	US20260022132, Compound 754a(1)	GTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049]			 7.50							US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437150	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=497&target=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437150&enzyme=GTPase+KRas+%5B1-169%2CG12V%5D%2FSon+of+sevenless+homolog+1+%5B564-1049%5D&column=ki&startPg=0&Increment=50&submit=Search			134493797	439658779							2	EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT	3KSY,1XD4,8XJJ,9TK2,9QFF,5OVI,5OVH,5OVG,5OVF,5OVE,5OVD,2II0,8BEA,8BE9,8BE8,8BE7,8BE6,8BE5,8BE4,8BE2,7KFZ,4US2,4US1,4US0,4URZ,4URY,4URX,4URW,4URV,4URU,9MJM,9MJL,7UKS,7UKR,7AVV,7AVU,7AVT,7AVS,7AVL,7AVI,6SFR,6SCM,6EPP,6EPO,6EPN,6EPM,6EPL,1XD2,1XDV,4NYM,4NYJ,4NYI,1NVX,1NVW,1NVV,1NVU,6V9O,6V9N,6V9M,6V9L,6V9J,6V9F,6V94,6D5W,6D5V,6D5M,6D5L,6D5J,6D5H,6D5G,6D5E,6D59,6D56,6D55,6CUR,6CUP,6CUO,6BVM,6BVL,6BVK,6BVJ,6BVI,5WFR,5WFQ,5WFP,5WFO,1BKD	Son of sevenless homolog 1	SOS1_HUMAN	Q07889	A8K2G3 B4DXG2							MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK	9I5E,5V9O,5V9L,5V71,5KYK,6MQN,7NY8,6YXW,6GJ8,8PI0,5TB5,5TAR,6YR8,7RSE,7RSC,6W4E,7RP3,6GOD,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,9PZY,9C41,5VQ0,5VPZ,5VPY,5VPI,5VP7,5WHE,5WHD,9PVF,5UK9,5UFE,6GOF,6WS4,8JJS,7YV1,7YUZ,24HT,24HS,24HR,9C43,5UFQ,9C3Q,6P0Z,8STN,7F0W,7EYX,6M9W,8AFC,9BG5,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9C40,9U99	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																						
211987	Nc1cc(Cl)c2c(c1F)[C@]1(CCC2)Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc(N3CCCOCC3)c2CO1	InChI=1S/C29H36ClF2N5O3/c30-21-12-22(33)25(32)24-19(21)4-1-6-29(24)14-23-20(16-40-29)26(36-7-3-10-38-11-9-36)35-27(34-23)39-17-28-5-2-8-37(28)15-18(31)13-28/h12,18H,1-11,13-17,33H2	BVKBLWHFCAQFOA-UHFFFAOYSA-N	437151	US20260022132, Compound 181b	GTPase KRas [G12V]	Homo sapiens			 250						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437151	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437151&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134494108	439658780							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
211988	Cc1cc(N)c(F)c2c1CCCC21Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc(N3CCCn4nc(C(=O)N(C)C)cc4C3)c2CO1	InChI=1S/C35H44F2N8O3/c1-21-13-26(38)30(37)29-24(21)7-4-9-35(29)16-28-25(19-48-35)31(40-33(39-28)47-20-34-8-5-11-44(34)17-22(36)15-34)43-10-6-12-45-23(18-43)14-27(41-45)32(46)42(2)3/h13-14,22H,4-12,15-20,38H2,1-3H3	AKSQNOMFRXXNMX-UHFFFAOYSA-N	436794	5-(7-amino-8-fluoro-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-5-methyl-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidin]-4'-yl)-N,N-dimethyl-5,6,7,8-tetrahydro-4H-pyrazolo[1,5-a][1,4]diazepine-2-carboxamide ::US20260022132, Compound 501a	GTPase KRas [G12V]	Homo sapiens			 34.0						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436794	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436794&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493954	439658423							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
211989	Cc1cc(N)c(F)c2c1CCC[C@]21Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc(N3CCCn4nc(C(=O)N(C)C)cc4C3)c2CO1	InChI=1S/C35H44F2N8O3/c1-21-13-26(38)30(37)29-24(21)7-4-9-35(29)16-28-25(19-48-35)31(40-33(39-28)47-20-34-8-5-11-44(34)17-22(36)15-34)43-10-6-12-45-23(18-43)14-27(41-45)32(46)42(2)3/h13-14,22H,4-12,15-20,38H2,1-3H3	AKSQNOMFRXXNMX-UHFFFAOYSA-N	436795	5-((S)-7-amino-8-fluoro-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-5-methyl-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidin]-4'-yl)-N,N-dimethyl-5,6,7,8-tetrahydro-4H-pyrazolo[1,5-a][1,4]diazepine-2-carboxamide ::US20260022132, Compound 501b	GTPase KRas [G12V]	Homo sapiens			 19.0						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436795	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436795&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493772	439658424							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
211990	Cc1cc(N)c(F)c2c1CCC[C@@]21Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc(N3CCCn4nc(C(=O)N(C)C)cc4C3)c2CO1	InChI=1S/C35H44F2N8O3/c1-21-13-26(38)30(37)29-24(21)7-4-9-35(29)16-28-25(19-48-35)31(40-33(39-28)47-20-34-8-5-11-44(34)17-22(36)15-34)43-10-6-12-45-23(18-43)14-27(41-45)32(46)42(2)3/h13-14,22H,4-12,15-20,38H2,1-3H3	AKSQNOMFRXXNMX-UHFFFAOYSA-N	436796	5-((R)-7-amino-8-fluoro-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-5-methyl-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidin]-4'-yl)-N,N-dimethyl-5,6,7,8-tetrahydro-4H-pyrazolo[1,5-a][1,4]diazepine-2-carboxamide ::US20260022132, Compound 501c	GTPase KRas [G12V]	Homo sapiens			>5000						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436796	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436796&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493700	439658425							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
211991	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCC[C@@H](C#N)CC4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C33H40FN7O2/c1-21-7-10-33(29-24(21)5-6-27(37)25(29)17-36)15-28-26(19-43-33)30(40-11-2-4-22(16-35)8-13-40)39-31(38-28)42-20-32-9-3-12-41(32)18-23(34)14-32/h5-6,21-23H,2-4,7-15,18-20,37H2,1H3	NWVHCBTZYXKQBO-UHFFFAOYSA-N	436797	(1S,4S)-7-amino-4'-((R*)-4-cyanoazepan-1-yl)-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-4-methyl-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidine]-8-carbonitrile ::US20260022132, Compound 502a	GTPase KRas [G12V]	Homo sapiens			 0.240						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436797	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436797&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493686	439658426							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
211992	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCC[C@@H](C#N)CC4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C33H40FN7O2/c1-21-7-10-33(29-24(21)5-6-27(37)25(29)17-36)15-28-26(19-43-33)30(40-11-2-4-22(16-35)8-13-40)39-31(38-28)42-20-32-9-3-12-41(32)18-23(34)14-32/h5-6,21-23H,2-4,7-15,18-20,37H2,1H3	NWVHCBTZYXKQBO-UHFFFAOYSA-N	436797	(1S,4S)-7-amino-4'-((R*)-4-cyanoazepan-1-yl)-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-4-methyl-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidine]-8-carbonitrile ::US20260022132, Compound 502a	GTPase KRas [G12V]	Homo sapiens			 4.10						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436797	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436797&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493686	439658426							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
211993	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCC[C@H](C#N)CC4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C33H40FN7O2/c1-21-7-10-33(29-24(21)5-6-27(37)25(29)17-36)15-28-26(19-43-33)30(40-11-2-4-22(16-35)8-13-40)39-31(38-28)42-20-32-9-3-12-41(32)18-23(34)14-32/h5-6,21-23H,2-4,7-15,18-20,37H2,1H3	NWVHCBTZYXKQBO-UHFFFAOYSA-N	436798	(1S,4S)-7-amino-4'-((S*)-4-cyanoazepan-1-yl)-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-4-methyl-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidine]-8-carbonitrile ::US20260022132, Compound 502b	GTPase KRas [G12V]	Homo sapiens			 0.340						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436798	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436798&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493784	439658427							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
211994	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCC[C@H](C#N)CC4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C33H40FN7O2/c1-21-7-10-33(29-24(21)5-6-27(37)25(29)17-36)15-28-26(19-43-33)30(40-11-2-4-22(16-35)8-13-40)39-31(38-28)42-20-32-9-3-12-41(32)18-23(34)14-32/h5-6,21-23H,2-4,7-15,18-20,37H2,1H3	NWVHCBTZYXKQBO-UHFFFAOYSA-N	436798	(1S,4S)-7-amino-4'-((S*)-4-cyanoazepan-1-yl)-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-4-methyl-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidine]-8-carbonitrile ::US20260022132, Compound 502b	GTPase KRas [G12V]	Homo sapiens			 3.90						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436798	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436798&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493784	439658427							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
211995	N#Cc1c(N)ccc2c1C1(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCCOCC4)c3CO1)C1CC2C1	InChI=1S/C31H37FN6O3/c32-21-13-30(5-1-7-38(30)16-21)18-40-29-35-26-14-31(41-17-24(26)28(36-29)37-6-2-9-39-10-8-37)20-11-19(12-20)22-3-4-25(34)23(15-33)27(22)31/h3-4,19-21H,1-2,5-14,16-18,34H2	UZDBRLGBTAUPGA-UHFFFAOYSA-N	436799	6'-Amino-2-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-4-(1,4-oxazepan-4-yl)-2',3',5,8-tetrahydro-1'H-spiro[pyrano[4,3-d]pyrimidine-7,4'-[1,3]methanonaphthalene]-5'-carbonitrile ::US20260022132, Compound 503a	GTPase KRas [G12V]	Homo sapiens			 970						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436799	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436799&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490019	439658428							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
211996	N#Cc1c(N)ccc2c1[C@]1(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCCOCC4)c3CO1)C1CC2C1	InChI=1S/C31H37FN6O3/c32-21-13-30(5-1-7-38(30)16-21)18-40-29-35-26-14-31(41-17-24(26)28(36-29)37-6-2-9-39-10-8-37)20-11-19(12-20)22-3-4-25(34)23(15-33)27(22)31/h3-4,19-21H,1-2,5-14,16-18,34H2	UZDBRLGBTAUPGA-UHFFFAOYSA-N	436800	(7S)-6'-Amino-2-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-4-(1,4-oxazepan-4-yl)-2',3',5,8-tetrahydro-1'H-spiro[pyrano[4,3-d]pyrimidine-7,4'-[1,3]methanonaphthalene]-5'-carbonitrile ::US20260022132, Compound 503b	GTPase KRas [G12V]	Homo sapiens			>5000						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436800	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436800&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134494024	439658429							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
211997	N#Cc1c(N)ccc2c1[C@@]1(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCCOCC4)c3CO1)C1CC2C1	InChI=1S/C31H37FN6O3/c32-21-13-30(5-1-7-38(30)16-21)18-40-29-35-26-14-31(41-17-24(26)28(36-29)37-6-2-9-39-10-8-37)20-11-19(12-20)22-3-4-25(34)23(15-33)27(22)31/h3-4,19-21H,1-2,5-14,16-18,34H2	UZDBRLGBTAUPGA-UHFFFAOYSA-N	436801	(7R)-6'-Amino-2-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-4-(1,4-oxazepan-4-yl)-2',3',5,8-tetrahydro-1'H-spiro[pyrano[4,3-d]pyrimidine-7,4'-[1,3]methanonaphthalene]-5'-carbonitrile ::US20260022132, Compound 503c	GTPase KRas [G12V]	Homo sapiens			 580						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436801	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436801&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493733	439658430							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
211998	CN(C)C(=O)c1cc2n(n1)CCCN(c1nc(OC[C@@]34CCCN3C[C@H](F)C4)nc3c1CO[C@@]1(C3)c3c(ccc(N)c3C#N)C3CC1C3)C2	InChI=1S/C36H42FN9O3/c1-43(2)33(47)29-13-24-18-44(8-4-10-46(24)42-29)32-27-19-49-36(22-11-21(12-22)25-5-6-28(39)26(16-38)31(25)36)15-30(27)40-34(41-32)48-20-35-7-3-9-45(35)17-23(37)14-35/h5-6,13,21-23H,3-4,7-12,14-15,17-20,39H2,1-2H3	ZGIJEKLVPIKVJJ-UHFFFAOYSA-N	436802	5-((7R)-6'-amino-5'-cyano-2-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-2',3',5,8-tetrahydro-1'H-spiro[pyrano[4,3-d]pyrimidine-7,4'-[1,3]methanonaphthalen]-4-yl)-N,N-dimethyl-5,6,7,8-tetrahydro-4H-pyrazolo[1,5-a][1,4]diazepine-2-carboxamide ::US20260022132, Compound 504a	GTPase KRas [G12V]	Homo sapiens			 8.40						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436802	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436802&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490023	439658431							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
211999	CN(C)C(=O)c1cc2n(n1)CCCN(c1nc(OC[C@@]34CCCN3C[C@H](F)C4)nc3c1COC1(C3)c3c(ccc(N)c3C#N)C3CC1C3)C2	InChI=1S/C36H42FN9O3/c1-43(2)33(47)29-13-24-18-44(8-4-10-46(24)42-29)32-27-19-49-36(22-11-21(12-22)25-5-6-28(39)26(16-38)31(25)36)15-30(27)40-34(41-32)48-20-35-7-3-9-45(35)17-23(37)14-35/h5-6,13,21-23H,3-4,7-12,14-15,17-20,39H2,1-2H3	ZGIJEKLVPIKVJJ-UHFFFAOYSA-N	436803	5-(6'-Amino-5'-cyano-2-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-2',3',5,8-tetrahydro-1'H-spiro[pyrano[4,3-d]pyrimidine-7,4'-[1,3]methanonaphthalen]-4-yl)-N,N-dimethyl-5,6,7,8-tetrahydro-4H-pyrazolo[1,5-a][1,4]diazepine-2-carboxamide ::US20260022132, Compound 504b	GTPase KRas [G12V]	Homo sapiens			 6.00						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436803	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436803&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490020	439658432							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212000	CN(C)C(=O)c1cc2n(n1)CCCN(c1nc(OC[C@@]34CCCN3C[C@H](F)C4)nc3c1CO[C@]1(C3)c3c(ccc(N)c3C#N)C3CC1C3)C2	InChI=1S/C36H42FN9O3/c1-43(2)33(47)29-13-24-18-44(8-4-10-46(24)42-29)32-27-19-49-36(22-11-21(12-22)25-5-6-28(39)26(16-38)31(25)36)15-30(27)40-34(41-32)48-20-35-7-3-9-45(35)17-23(37)14-35/h5-6,13,21-23H,3-4,7-12,14-15,17-20,39H2,1-2H3	ZGIJEKLVPIKVJJ-UHFFFAOYSA-N	436804	5-((7S)-6'-amino-5'-cyano-2-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-2',3',5,8-tetrahydro-1'H-spiro[pyrano[4,3-d]pyrimidine-7,4'-[1,3]methanonaphthalen]-4-yl)-N,N-dimethyl-5,6,7,8-tetrahydro-4H-pyrazolo[1,5-a][1,4]diazepine-2-carboxamide ::US20260022132, Compound 504c	GTPase KRas [G12V]	Homo sapiens			>5000						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436804	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436804&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490021	439658433							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212001	Cc1cc(N)c(C#N)c2c1CCCC21Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc(N3CCCOCC3)c2CO1	InChI=1S/C31H39FN6O3/c1-20-13-25(34)23(16-33)27-22(20)5-2-7-31(27)15-26-24(18-41-31)28(37-8-4-11-39-12-10-37)36-29(35-26)40-19-30-6-3-9-38(30)17-21(32)14-30/h13,21H,2-12,14-15,17-19,34H2,1H3	MDLDHWUSUSXCHD-UHFFFAOYSA-N	436805	7-Amino-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-5-methyl-4'-(1,4-oxazepan-4-yl)-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidine]-8-carbonitrile ::US20260022132, Compound 505a	GTPase KRas [G12V]	Homo sapiens			 170						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436805	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436805&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490022	439658434							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212002	Cc1cc(N)c(F)c2c1CCCC21Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc(N3CCCOCC3)c2CO1	InChI=1S/C30H39F2N5O3/c1-19-13-23(33)26(32)25-21(19)5-2-7-30(25)15-24-22(17-40-30)27(36-8-4-11-38-12-10-36)35-28(34-24)39-18-29-6-3-9-37(29)16-20(31)14-29/h13,20H,2-12,14-18,33H2,1H3	GKQQFCIKDFXNEX-UHFFFAOYSA-N	436806	8-Fluoro-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-5-methyl-4'-(1,4-oxazepan-4-yl)-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidin]-7-amine ::US20260022132, Compound 506a	GTPase KRas [G12V]	Homo sapiens			>5000						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436806	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436806&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493792	439658435							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212003	CN(C)C(=O)c1nn2c(c1Cl)CN(c1nc(OC[C@@]34CCCN3C[C@H](F)C4)nc3c1COC1(CCCc4ccc(N)c(C#N)c41)C3)CCC2	InChI=1S/C35H41ClFN9O3/c1-43(2)32(47)30-29(36)27-18-44(11-5-13-46(27)42-30)31-24-19-49-35(10-3-6-21-7-8-25(39)23(16-38)28(21)35)15-26(24)40-33(41-31)48-20-34-9-4-12-45(34)17-22(37)14-34/h7-8,22H,3-6,9-15,17-20,39H2,1-2H3	UVCFFLFDHUHSQW-UHFFFAOYSA-N	436807	5-(7-Amino-8-cyano-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidin]-4'-yl)-3-chloro-N,N-dimethyl-5,6,7,8-tetrahydro-4H-pyrazolo[1,5-a][1,4]diazepine-2-carboxamide ::US20260022132, Compound 507a	GTPase KRas [G12V]	Homo sapiens			 0.082						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436807	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436807&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493997	439658436							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212004	CN(C)C(=O)c1nn2c(c1Cl)CN(c1nc(OC[C@@]34CCCN3C[C@H](F)C4)nc3c1COC1(CCCc4ccc(N)c(C#N)c41)C3)CCC2	InChI=1S/C35H41ClFN9O3/c1-43(2)32(47)30-29(36)27-18-44(11-5-13-46(27)42-30)31-24-19-49-35(10-3-6-21-7-8-25(39)23(16-38)28(21)35)15-26(24)40-33(41-31)48-20-34-9-4-12-45(34)17-22(37)14-34/h7-8,22H,3-6,9-15,17-20,39H2,1-2H3	UVCFFLFDHUHSQW-UHFFFAOYSA-N	436807	5-(7-Amino-8-cyano-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidin]-4'-yl)-3-chloro-N,N-dimethyl-5,6,7,8-tetrahydro-4H-pyrazolo[1,5-a][1,4]diazepine-2-carboxamide ::US20260022132, Compound 507a	GTPase KRas [G12V]	Homo sapiens			 0.240						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436807	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436807&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493997	439658436							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212005	CN(C)C(=O)c1nn2c(c1Cl)CN(c1nc(OC[C@@]34CCCN3C[C@H](F)C4)nc3c1CO[C@@]1(CCCc4ccc(N)c(C#N)c41)C3)CCC2	InChI=1S/C35H41ClFN9O3/c1-43(2)32(47)30-29(36)27-18-44(11-5-13-46(27)42-30)31-24-19-49-35(10-3-6-21-7-8-25(39)23(16-38)28(21)35)15-26(24)40-33(41-31)48-20-34-9-4-12-45(34)17-22(37)14-34/h7-8,22H,3-6,9-15,17-20,39H2,1-2H3	UVCFFLFDHUHSQW-UHFFFAOYSA-N	436808	5-((S)-7-Amino-8-cyano-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidin]-4'-yl)-3-chloro-N,N-dimethyl-5,6,7,8-tetrahydro-4H-pyrazolo[1,5-a][1,4]diazepine-2-carboxamide ::US20260022132, Compound 507b	GTPase KRas [G12V]	Homo sapiens			 0.058						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436808	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436808&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493718	439658437							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212006	CN(C)C(=O)c1nn2c(c1Cl)CN(c1nc(OC[C@@]34CCCN3C[C@H](F)C4)nc3c1CO[C@@]1(CCCc4ccc(N)c(C#N)c41)C3)CCC2	InChI=1S/C35H41ClFN9O3/c1-43(2)32(47)30-29(36)27-18-44(11-5-13-46(27)42-30)31-24-19-49-35(10-3-6-21-7-8-25(39)23(16-38)28(21)35)15-26(24)40-33(41-31)48-20-34-9-4-12-45(34)17-22(37)14-34/h7-8,22H,3-6,9-15,17-20,39H2,1-2H3	UVCFFLFDHUHSQW-UHFFFAOYSA-N	436808	5-((S)-7-Amino-8-cyano-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidin]-4'-yl)-3-chloro-N,N-dimethyl-5,6,7,8-tetrahydro-4H-pyrazolo[1,5-a][1,4]diazepine-2-carboxamide ::US20260022132, Compound 507b	GTPase KRas [G12V]	Homo sapiens			 0.110						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436808	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436808&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493718	439658437							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212007	CN(C)C(=O)c1nn2c(c1Cl)CN(c1nc(OC[C@@]34CCCN3C[C@H](F)C4)nc3c1CO[C@]1(CCCc4ccc(N)c(C#N)c41)C3)CCC2	InChI=1S/C35H41ClFN9O3/c1-43(2)32(47)30-29(36)27-18-44(11-5-13-46(27)42-30)31-24-19-49-35(10-3-6-21-7-8-25(39)23(16-38)28(21)35)15-26(24)40-33(41-31)48-20-34-9-4-12-45(34)17-22(37)14-34/h7-8,22H,3-6,9-15,17-20,39H2,1-2H3	UVCFFLFDHUHSQW-UHFFFAOYSA-N	436809	5-((R)-7-Amino-8-cyano-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidin]-4'-yl)-3-chloro-N,N-dimethyl-5,6,7,8-tetrahydro-4H-pyrazolo[1,5-a][1,4]diazepine-2-carboxamide ::US20260022132, Compound 507c	GTPase KRas [G12V]	Homo sapiens			 54.0						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436809	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436809&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493699	439658438							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212008	CC1CCC2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCCOCC4)c3CO2)c2c(F)c(N)cc(Cl)c21	InChI=1S/C30H38ClF2N5O3/c1-18-4-6-30(25-24(18)21(31)12-22(34)26(25)33)14-23-20(16-41-30)27(37-7-3-10-39-11-9-37)36-28(35-23)40-17-29-5-2-8-38(29)15-19(32)13-29/h12,18-19H,2-11,13-17,34H2,1H3	ULAWITNEZNGQKF-UHFFFAOYSA-N	436810	5-Chloro-8-fluoro-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-4-methyl-4'-(1,4-oxazepan-4-yl)-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidin]-7-amine ::US20260022132, Compound 508a	GTPase KRas [G12V]	Homo sapiens			 140						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436810	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436810&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493830	439658439							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212009	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCCn5nc(C(=O)N(C)C)c(Cl)c5C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C36H43ClFN9O3/c1-21-8-10-36(29-23(21)6-7-26(40)24(29)16-39)15-27-25(19-50-36)32(42-34(41-27)49-20-35-9-4-12-46(35)17-22(38)14-35)45-11-5-13-47-28(18-45)30(37)31(43-47)33(48)44(2)3/h6-7,21-22H,4-5,8-15,17-20,40H2,1-3H3	SDNSBDOTDDGQBP-UHFFFAOYSA-N	436811	5-((1S,4S)-7-Amino-8-cyano-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-4-methyl-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidin]-4'-yl)-3-chloro-N,N-dimethyl-5,6,7,8-tetrahydro-4H-pyrazolo[1,5-a][1,4]diazepine-2-carboxamide ::US20260022132, Compound 509a	GTPase KRas [G12V]	Homo sapiens			 0.030						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436811	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436811&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493711	439658440							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212010	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCCn5nc(C(=O)N(C)C)c(Cl)c5C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C36H43ClFN9O3/c1-21-8-10-36(29-23(21)6-7-26(40)24(29)16-39)15-27-25(19-50-36)32(42-34(41-27)49-20-35-9-4-12-46(35)17-22(38)14-35)45-11-5-13-47-28(18-45)30(37)31(43-47)33(48)44(2)3/h6-7,21-22H,4-5,8-15,17-20,40H2,1-3H3	SDNSBDOTDDGQBP-UHFFFAOYSA-N	436811	5-((1S,4S)-7-Amino-8-cyano-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-4-methyl-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidin]-4'-yl)-3-chloro-N,N-dimethyl-5,6,7,8-tetrahydro-4H-pyrazolo[1,5-a][1,4]diazepine-2-carboxamide ::US20260022132, Compound 509a	GTPase KRas [G12V]	Homo sapiens			 0.023						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436811	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436811&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493711	439658440							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212011	C[C@H]1CC[C@@]2(Cc3nc(OC[C@@]45CC(F)CN4C[C@H](F)C5)nc(N4CCCn5nc(C(=O)N(C)C)c(Cl)c5C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C36H42ClF2N9O3/c1-20-7-8-36(29-23(20)5-6-26(41)24(29)14-40)13-27-25(18-51-36)32(43-34(42-27)50-19-35-11-21(38)15-47(35)16-22(39)12-35)46-9-4-10-48-28(17-46)30(37)31(44-48)33(49)45(2)3/h5-6,20-22H,4,7-13,15-19,41H2,1-3H3	BCKNLVPNHWXURD-UHFFFAOYSA-N	436812	5-((1R,4S)-7-Amino-8-cyano-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-4-methyl-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidin]-4'-yl)-3-chloro-N,N-dimethyl-5,6,7,8-tetrahydro-4H-pyrazolo[1,5-a][1,4]diazepine-2-carboxamide ::US20260022132, Compound 509b	GTPase KRas [G12V]	Homo sapiens			 8.20						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436812	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436812&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493762	439658441							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212012	N#C[C@H]1CCCN(c2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc3c2COC2(CCCc4c(Cl)cc(N)c(F)c42)C3)CC1	InChI=1S/C31H37ClF2N6O2/c32-23-12-24(36)27(34)26-21(23)5-1-8-31(26)14-25-22(17-42-31)28(39-9-2-4-19(15-35)6-11-39)38-29(37-25)41-18-30-7-3-10-40(30)16-20(33)13-30/h12,19-20H,1-11,13-14,16-18,36H2	WHLJSIGCNLEYSF-UHFFFAOYSA-N	436813	(4S*)-1-(7-amino-5-chloro-8-fluoro-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidin]-4'-yl)azepane-4-carbonitrile ::US20260022132, Compound 510a	GTPase KRas [G12V]	Homo sapiens			>5000						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436813	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436813&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493706	439658442							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212013	N#C[C@@H]1CCCN(c2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc3c2COC2(CCCc4c(Cl)cc(N)c(F)c42)C3)CC1	InChI=1S/C31H37ClF2N6O2/c32-23-12-24(36)27(34)26-21(23)5-1-8-31(26)14-25-22(17-42-31)28(39-9-2-4-19(15-35)6-11-39)38-29(37-25)41-18-30-7-3-10-40(30)16-20(33)13-30/h12,19-20H,1-11,13-14,16-18,36H2	WHLJSIGCNLEYSF-UHFFFAOYSA-N	436814	(R*)-1-(7-amino-5-chloro-8-fluoro-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidin]-4'-yl)azepane-4-carbonitrile ::US20260022132, Compound 510b	GTPase KRas [G12V]	Homo sapiens			 330						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436814	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436814&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493863	439658443							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212014	N#C[C@H]1CCCN(c2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc3c2CO[C@]2(CCCc4c(Cl)cc(N)c(F)c42)C3)CC1	InChI=1S/C31H37ClF2N6O2/c32-23-12-24(36)27(34)26-21(23)5-1-8-31(26)14-25-22(17-42-31)28(39-9-2-4-19(15-35)6-11-39)38-29(37-25)41-18-30-7-3-10-40(30)16-20(33)13-30/h12,19-20H,1-11,13-14,16-18,36H2	WHLJSIGCNLEYSF-UHFFFAOYSA-N	436815	(S*)-1-((R)-7-amino-5-chloro-8-fluoro-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidin]-4'-yl)azepane-4-carbonitrile ::US20260022132, Compound 510c	GTPase KRas [G12V]	Homo sapiens			>5000						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436815	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436815&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493586	439658444							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212015	N#C[C@H]1CCCN(c2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc3c2CO[C@@]2(CCCc4c(Cl)cc(N)c(F)c42)C3)CC1	InChI=1S/C31H37ClF2N6O2/c32-23-12-24(36)27(34)26-21(23)5-1-8-31(26)14-25-22(17-42-31)28(39-9-2-4-19(15-35)6-11-39)38-29(37-25)41-18-30-7-3-10-40(30)16-20(33)13-30/h12,19-20H,1-11,13-14,16-18,36H2	WHLJSIGCNLEYSF-UHFFFAOYSA-N	436816	(S*)-1-((S)-7-amino-5-chloro-8-fluoro-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidin]-4'-yl)azepane-4-carbonitrile ::US20260022132, Compound 510d	GTPase KRas [G12V]	Homo sapiens			 1000						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436816	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436816&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493736	439658445							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212016	N#C[C@@H]1CCCN(c2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc3c2CO[C@]2(CCCc4c(Cl)cc(N)c(F)c42)C3)CC1	InChI=1S/C31H37ClF2N6O2/c32-23-12-24(36)27(34)26-21(23)5-1-8-31(26)14-25-22(17-42-31)28(39-9-2-4-19(15-35)6-11-39)38-29(37-25)41-18-30-7-3-10-40(30)16-20(33)13-30/h12,19-20H,1-11,13-14,16-18,36H2	WHLJSIGCNLEYSF-UHFFFAOYSA-N	436817	(R*)-1-((R)-7-amino-5-chloro-8-fluoro-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidin]-4'-yl)azepane-4-carbonitrile ::US20260022132, Compound 510e	GTPase KRas [G12V]	Homo sapiens			>5000						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436817	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436817&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493727	439658446							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212017	N#C[C@@H]1CCCN(c2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc3c2CO[C@@]2(CCCc4c(Cl)cc(N)c(F)c42)C3)CC1	InChI=1S/C31H37ClF2N6O2/c32-23-12-24(36)27(34)26-21(23)5-1-8-31(26)14-25-22(17-42-31)28(39-9-2-4-19(15-35)6-11-39)38-29(37-25)41-18-30-7-3-10-40(30)16-20(33)13-30/h12,19-20H,1-11,13-14,16-18,36H2	WHLJSIGCNLEYSF-UHFFFAOYSA-N	436818	(R*)-1-((S)-7-amino-5-chloro-8-fluoro-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidin]-4'-yl)azepane-4-carbonitrile ::US20260022132, Compound 510f	GTPase KRas [G12V]	Homo sapiens			 210						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436818	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436818&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493587	439658447							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212018	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCC[C@@H](CC#N)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C33H40FN7O2/c1-21-7-10-33(29-24(21)5-6-27(37)25(29)16-36)15-28-26(19-43-33)30(40-12-2-4-22(17-40)8-11-35)39-31(38-28)42-20-32-9-3-13-41(32)18-23(34)14-32/h5-6,21-23H,2-4,7-10,12-15,17-20,37H2,1H3	VGEIIJXEWCRVBJ-UHFFFAOYSA-N	436819	(1S,4S)-7-Amino-4'-((S)-3-(cyanomethyl)piperidin-1-yl)-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-4-methyl-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidine]-8-carbonitrile ::US20260022132, Compound 511a	GTPase KRas [G12V]	Homo sapiens			 0.120						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436819	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436819&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134494032	439658448							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212019	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCC[C@@H](CC#N)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C33H40FN7O2/c1-21-7-10-33(29-24(21)5-6-27(37)25(29)16-36)15-28-26(19-43-33)30(40-12-2-4-22(17-40)8-11-35)39-31(38-28)42-20-32-9-3-13-41(32)18-23(34)14-32/h5-6,21-23H,2-4,7-10,12-15,17-20,37H2,1H3	VGEIIJXEWCRVBJ-UHFFFAOYSA-N	436819	(1S,4S)-7-Amino-4'-((S)-3-(cyanomethyl)piperidin-1-yl)-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-4-methyl-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidine]-8-carbonitrile ::US20260022132, Compound 511a	GTPase KRas [G12V]	Homo sapiens			 2.40						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436819	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436819&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134494032	439658448							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212020	N#Cc1c(N)ccc2c1[C@@]1(CC[C@H]2C(F)(F)F)Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc(N3CCCOCC3)c2CO1	InChI=1S/C31H36F4N6O3/c32-19-13-29(6-1-9-41(29)16-19)18-43-28-38-25-14-30(44-17-22(25)27(39-28)40-8-2-11-42-12-10-40)7-5-23(31(33,34)35)20-3-4-24(37)21(15-36)26(20)30/h3-4,19,23H,1-2,5-14,16-18,37H2	HECHKKOQASXFHC-UHFFFAOYSA-N	436820	(1R*,4R)-7-amino-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-4'-(1,4-oxazepan-4-yl)-4-(trifluoromethyl)-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidine]-8-carbonitrile ::US20260022132, Compound 512a	GTPase KRas [G12V]	Homo sapiens			>5000						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436820	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436820&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493869	439658449							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212021	N#Cc1c(N)ccc2c1[C@]1(CC[C@@H]2C(F)(F)F)Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc(N3CCCOCC3)c2CO1	InChI=1S/C31H36F4N6O3/c32-19-13-29(6-1-9-41(29)16-19)18-43-28-38-25-14-30(44-17-22(25)27(39-28)40-8-2-11-42-12-10-40)7-5-23(31(33,34)35)20-3-4-24(37)21(15-36)26(20)30/h3-4,19,23H,1-2,5-14,16-18,37H2	HECHKKOQASXFHC-UHFFFAOYSA-N	436821	(1S*,4S)-7-Amino-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-4'-(1,4-oxazepan-4-yl)-4-(trifluoromethyl)-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidine]-8-carbonitrile ::US20260022132, Compound 512b	GTPase KRas [G12V]	Homo sapiens			 3.80						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436821	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436821&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493779	439658450							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212022	CN(C)C(=O)c1cc2n(n1)CCCN(c1nc(OC[C@@H]3CCCN3C)nc3c1COC1(CCCc4ccc(N)c(C#N)c41)C3)C2	InChI=1S/C33H41N9O3/c1-39(2)31(43)27-15-23-18-41(13-6-14-42(23)38-27)30-25-20-45-33(11-4-7-21-9-10-26(35)24(17-34)29(21)33)16-28(25)36-32(37-30)44-19-22-8-5-12-40(22)3/h9-10,15,22H,4-8,11-14,16,18-20,35H2,1-3H3	WPYMDJFWMSLJPU-UHFFFAOYSA-N	436822	5-(7-amino-8-cyano-2'-(((S)-1-methylpyrrolidin-2-yl)methoxy)-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidin]-4'-yl)-N,N-dimethyl-5,6,7,8-tetrahydro-4H-pyrazolo[1,5-a][1,4]diazepine-2-carboxamide ::US20260022132, Compound 513a	GTPase KRas [G12V]	Homo sapiens			 4.50						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436822	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436822&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134494029	439658451							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212023	CN1CC[C@@H](COc2nc3c(c(N4CCCn5nc(C(=O)N(C)C)cc5C4)n2)COC2(CCCc4ccc(N)c(C#N)c42)C3)C1	InChI=1S/C33H41N9O3/c1-39(2)31(43)27-14-23-18-41(11-5-12-42(23)38-27)30-25-20-45-33(10-4-6-22-7-8-26(35)24(16-34)29(22)33)15-28(25)36-32(37-30)44-19-21-9-13-40(3)17-21/h7-8,14,21H,4-6,9-13,15,17-20,35H2,1-3H3	OJOXRWJXEKHICJ-UHFFFAOYSA-N	436823	5-(7-Amino-8-cyano-2'-(((R)-1-methylpyrrolidin-3-yl)methoxy)-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidin]-4'-yl)-N,N-dimethyl-5,6,7,8-tetrahydro-4H-pyrazolo[1,5-a][1,4]diazepine-2-carboxamide ::US20260022132, Compound 514a	GTPase KRas [G12V]	Homo sapiens			 18.0						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436823	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436823&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493564	439658452							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212024	CN1CC[C@H](COc2nc3c(c(N4CCCn5nc(C(=O)N(C)C)cc5C4)n2)COC2(CCCc4ccc(N)c(C#N)c42)C3)C1	InChI=1S/C33H41N9O3/c1-39(2)31(43)27-14-23-18-41(11-5-12-42(23)38-27)30-25-20-45-33(10-4-6-22-7-8-26(35)24(16-34)29(22)33)15-28(25)36-32(37-30)44-19-21-9-13-40(3)17-21/h7-8,14,21H,4-6,9-13,15,17-20,35H2,1-3H3	OJOXRWJXEKHICJ-UHFFFAOYSA-N	436824	5-(7-amino-8-cyano-2'-(((S)-1-methylpyrrolidin-3-yl)methoxy)-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidin]-4'-yl)-N,N-dimethyl-5,6,7,8-tetrahydro-4H-pyrazolo[1,5-a][1,4]diazepine-2-carboxamide ::US20260022132, Compound 514b	GTPase KRas [G12V]	Homo sapiens			 33.0						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436824	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436824&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493839	439658453							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212025	N#CC[C@H]1CN(c2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc3c2CO[C@@]2(CCCc4ccc(N)cc42)C3)CCO1	InChI=1S/C30H37FN6O3/c31-21-14-29(7-2-10-37(29)16-21)19-39-28-34-26-15-30(8-1-3-20-4-5-22(33)13-25(20)30)40-18-24(26)27(35-28)36-11-12-38-23(17-36)6-9-32/h4-5,13,21,23H,1-3,6-8,10-12,14-19,33H2	JYRYSJDOWRZWEH-UHFFFAOYSA-N	436825	2-((S)-4-((S)-7-amino-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidin]-4'-yl)morpholin-2-yl)acetonitrile ::US20260022132, Compound 515a	GTPase KRas [G12V]	Homo sapiens			 400						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436825	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436825&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493849	439658454							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212026	N#Cc1c(N)ccc2c1[C@]1(CCC2)Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc(N3CCOCC(n4cccn4)C3)c2CO1	InChI=1S/C33H39FN8O3/c34-23-14-32(7-2-10-41(32)17-23)21-44-31-38-28-15-33(8-1-4-22-5-6-27(36)25(16-35)29(22)33)45-20-26(28)30(39-31)40-12-13-43-19-24(18-40)42-11-3-9-37-42/h3,5-6,9,11,23-24H,1-2,4,7-8,10,12-15,17-21,36H2	ZVJCZISSZXHAHJ-UHFFFAOYSA-N	436826	(S)-4'-(6-(1H-pyrazol-1-yl)-1,4-oxazepan-4-yl)-7-amino-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidine]-8-carbonitrile ::US20260022132, Compound 516a	GTPase KRas [G12V]	Homo sapiens			 0.680						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436826	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436826&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134494034	439658455							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212027	N#Cc1c(N)ccc2c1[C@]1(CCC2)Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc(N3CCOCC(n4cccn4)C3)c2CO1	InChI=1S/C33H39FN8O3/c34-23-14-32(7-2-10-41(32)17-23)21-44-31-38-28-15-33(8-1-4-22-5-6-27(36)25(16-35)29(22)33)45-20-26(28)30(39-31)40-12-13-43-19-24(18-40)42-11-3-9-37-42/h3,5-6,9,11,23-24H,1-2,4,7-8,10,12-15,17-21,36H2	ZVJCZISSZXHAHJ-UHFFFAOYSA-N	436826	(S)-4'-(6-(1H-pyrazol-1-yl)-1,4-oxazepan-4-yl)-7-amino-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidine]-8-carbonitrile ::US20260022132, Compound 516a	GTPase KRas [G12V]	Homo sapiens			 6.60						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436826	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436826&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134494034	439658455							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212028	N#Cc1c(N)ccc2c1[C@]1(CCC2)Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc(N3CCOC[C@H](n4cccn4)C3)c2CO1	InChI=1S/C33H39FN8O3/c34-23-14-32(7-2-10-41(32)17-23)21-44-31-38-28-15-33(8-1-4-22-5-6-27(36)25(16-35)29(22)33)45-20-26(28)30(39-31)40-12-13-43-19-24(18-40)42-11-3-9-37-42/h3,5-6,9,11,23-24H,1-2,4,7-8,10,12-15,17-21,36H2	ZVJCZISSZXHAHJ-UHFFFAOYSA-N	436827	(S)-4'-((R)-6-(1H-pyrazol-1-yl)-1,4-oxazepan-4-yl)-7-amino-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidine]-8-carbonitrile ::US20260022132, Compound 516b	GTPase KRas [G12V]	Homo sapiens			 380						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436827	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436827&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134494035	439658456							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212029	N#Cc1c(N)ccc2c1[C@]1(CCC2)Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc(N3CCOC[C@@H](n4cccn4)C3)c2CO1	InChI=1S/C33H39FN8O3/c34-23-14-32(7-2-10-41(32)17-23)21-44-31-38-28-15-33(8-1-4-22-5-6-27(36)25(16-35)29(22)33)45-20-26(28)30(39-31)40-12-13-43-19-24(18-40)42-11-3-9-37-42/h3,5-6,9,11,23-24H,1-2,4,7-8,10,12-15,17-21,36H2	ZVJCZISSZXHAHJ-UHFFFAOYSA-N	436828	(S)-4'-((S)-6-(1H-pyrazol-1-yl)-1,4-oxazepan-4-yl)-7-amino-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidine]-8-carbonitrile ::US20260022132, Compound 516c	GTPase KRas [G12V]	Homo sapiens			 0.360						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436828	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436828&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134494011	439658457							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212030	N#Cc1c(N)ccc2c1[C@]1(CCC2)Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc(N3CCOC[C@@H](n4cccn4)C3)c2CO1	InChI=1S/C33H39FN8O3/c34-23-14-32(7-2-10-41(32)17-23)21-44-31-38-28-15-33(8-1-4-22-5-6-27(36)25(16-35)29(22)33)45-20-26(28)30(39-31)40-12-13-43-19-24(18-40)42-11-3-9-37-42/h3,5-6,9,11,23-24H,1-2,4,7-8,10,12-15,17-21,36H2	ZVJCZISSZXHAHJ-UHFFFAOYSA-N	436828	(S)-4'-((S)-6-(1H-pyrazol-1-yl)-1,4-oxazepan-4-yl)-7-amino-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidine]-8-carbonitrile ::US20260022132, Compound 516c	GTPase KRas [G12V]	Homo sapiens			 5.00						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436828	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436828&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134494011	439658457							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212031	Cn1nccc1C(=O)N1CC2(CCCCN(c3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc4c(F)c(-c5ccc(F)c6sc(N)c(C#N)c56)c(Cl)cc34)C2)C1	InChI=1S/C38H37ClF3N9O2S/c1-48-27(7-10-45-48)35(52)50-18-37(19-50)8-2-3-11-49(17-37)34-23-13-25(39)29(22-5-6-26(41)32-28(22)24(15-43)33(44)54-32)30(42)31(23)46-36(47-34)53-20-38-9-4-12-51(38)16-21(40)14-38/h5-7,10,13,21H,2-4,8-9,11-12,14,16-20,44H2,1H3	IIVOFBAPEBNFQG-UHFFFAOYSA-N	436829	5-((S)-7-amino-8-cyano-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidin]-4'-yl)-3-fluoro-N,N-dimethyl-5,6,7,8-tetrahydro-4H-pyrazolo[1,5-a][1,4]diazepine-2-carboxamide ::US20260022132, Compound 517a	GTPase KRas [G12V]	Homo sapiens			 0.027						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436829	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436829&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493788	439658458							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212032	Cn1nccc1C(=O)N1CC2(CCCCN(c3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc4c(F)c(-c5ccc(F)c6sc(N)c(C#N)c56)c(Cl)cc34)C2)C1	InChI=1S/C38H37ClF3N9O2S/c1-48-27(7-10-45-48)35(52)50-18-37(19-50)8-2-3-11-49(17-37)34-23-13-25(39)29(22-5-6-26(41)32-28(22)24(15-43)33(44)54-32)30(42)31(23)46-36(47-34)53-20-38-9-4-12-51(38)16-21(40)14-38/h5-7,10,13,21H,2-4,8-9,11-12,14,16-20,44H2,1H3	IIVOFBAPEBNFQG-UHFFFAOYSA-N	436829	5-((S)-7-amino-8-cyano-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidin]-4'-yl)-3-fluoro-N,N-dimethyl-5,6,7,8-tetrahydro-4H-pyrazolo[1,5-a][1,4]diazepine-2-carboxamide ::US20260022132, Compound 517a	GTPase KRas [G12V]	Homo sapiens			 0.180						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436829	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436829&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493788	439658458							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212033	N#Cc1c(N)ccc2c1[C@]1(CCC2)Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc(N3CCOCC4(COC4)C3)c2CO1	InChI=1S/C32H39FN6O4/c33-22-11-31(6-2-8-39(31)14-22)20-42-29-36-26-12-32(7-1-3-21-4-5-25(35)23(13-34)27(21)32)43-15-24(26)28(37-29)38-9-10-40-17-30(16-38)18-41-19-30/h4-5,22H,1-3,6-12,14-20,35H2	PVVFTTZPFXNBAO-UHFFFAOYSA-N	436830	(S)-7-Amino-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-4'-(2,6-dioxa-9-azaspiro[3.6]decan-9-yl)-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidine]-8-carbonitrile ::US20260022132, Compound 518a	GTPase KRas [G12V]	Homo sapiens			 7.80						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436830	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436830&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493578	439658459							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212034	CN(C)C(=O)C1COCCN(c2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc3c2CO[C@@]2(CCCc4ccc(N)c(C#N)c42)C3)C1	InChI=1S/C33H42FN7O4/c1-39(2)30(42)22-16-40(11-12-43-18-22)29-25-19-45-33(9-3-5-21-6-7-26(36)24(15-35)28(21)33)14-27(25)37-31(38-29)44-20-32-8-4-10-41(32)17-23(34)13-32/h6-7,22-23H,3-5,8-14,16-20,36H2,1-2H3	PTZKZIKSXSNAIK-UHFFFAOYSA-N	436831	4-((S)-7-amino-8-cyano-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidin]-4'-yl)-N,N-dimethyl-1,4-oxazepane-6-carboxamide ::US20260022132, Compound 519a	GTPase KRas [G12V]	Homo sapiens			 17.0						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436831	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436831&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493852	439658460							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212035	Cc1c(C(=O)N(C)C)nn2c1CN(c1nc(OC[C@@]34CCCN3C[C@H](F)C4)nc3c1CO[C@@]1(CCCc4ccc(N)c(C#N)c41)C3)CCC2	InChI=1S/C36H44FN9O3/c1-22-29-19-44(12-6-14-46(29)42-31(22)33(47)43(2)3)32-26-20-49-36(11-4-7-23-8-9-27(39)25(17-38)30(23)36)16-28(26)40-34(41-32)48-21-35-10-5-13-45(35)18-24(37)15-35/h8-9,24H,4-7,10-16,18-21,39H2,1-3H3	ZQUPECFCGPIVCP-UHFFFAOYSA-N	436832	5-((S)-7-amino-8-cyano-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidin]-4'-yl)-N,N,3-trimethyl-5,6,7,8-tetrahydro-4H-pyrazolo[1,5-a][1,4]diazepine-2-carboxamide ::US20260022132, Compound 520a	GTPase KRas [G12V]	Homo sapiens			 0.028						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436832	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436832&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493803	439658461							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212036	Cc1c(C(=O)N(C)C)nn2c1CN(c1nc(OC[C@@]34CCCN3C[C@H](F)C4)nc3c1CO[C@@]1(CCCc4ccc(N)c(C#N)c41)C3)CCC2	InChI=1S/C36H44FN9O3/c1-22-29-19-44(12-6-14-46(29)42-31(22)33(47)43(2)3)32-26-20-49-36(11-4-7-23-8-9-27(39)25(17-38)30(23)36)16-28(26)40-34(41-32)48-21-35-10-5-13-45(35)18-24(37)15-35/h8-9,24H,4-7,10-16,18-21,39H2,1-3H3	ZQUPECFCGPIVCP-UHFFFAOYSA-N	436832	5-((S)-7-amino-8-cyano-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidin]-4'-yl)-N,N,3-trimethyl-5,6,7,8-tetrahydro-4H-pyrazolo[1,5-a][1,4]diazepine-2-carboxamide ::US20260022132, Compound 520a	GTPase KRas [G12V]	Homo sapiens			 0.170						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436832	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436832&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493803	439658461							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212037	CN(C)C(=O)c1cc2n(n1)CCCN(c1nc(OC[C@@]34CCCN3C[C@H](F)C4)nc3c1CO[C@]1(C3)C[C@@H]3C[C@@H]3c3ccc(N)cc31)C2	InChI=1S/C35H43FN8O3/c1-41(2)32(45)29-13-24-18-42(8-4-10-44(24)40-29)31-27-19-47-35(14-21-11-26(21)25-6-5-23(37)12-28(25)35)16-30(27)38-33(39-31)46-20-34-7-3-9-43(34)17-22(36)15-34/h5-6,12-13,21-22,26H,3-4,7-11,14-20,37H2,1-2H3	LJVMZXAEACSCTI-UHFFFAOYSA-N	436833	5-((1aSR,3RS,7bSR)-5-amino-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-1,1a,2,5',7b,8'-hexahydrospiro[cyclopropa[a]naphthalene-3,7'-pyrano[4,3-d]pyrimidin]-4'-yl)-N,N-dimethyl-5,6,7,8-tetrahydro-4H-pyrazolo[1,5-a][1,4]diazepine-2-carboxamide ::US20260022132, Compound 521a	GTPase KRas [G12V]	Homo sapiens			 15.0						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436833	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436833&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493866	439658462							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212038	N#CC[C@H]1COCCCN1c1nc(OC[C@@]23CCCN2C[C@H](F)C3)nc2c1CO[C@@]1(CCCc3ccc(N)c(C#N)c31)C2	InChI=1S/C32H38FN7O3/c33-22-14-31(8-2-11-39(31)17-22)20-42-30-37-27-15-32(9-1-4-21-5-6-26(36)24(16-35)28(21)32)43-19-25(27)29(38-30)40-12-3-13-41-18-23(40)7-10-34/h5-6,22-23H,1-4,7-9,11-15,17-20,36H2	HTPQSDHPRMNJFO-UHFFFAOYSA-N	436834	(S)-7-Amino-4'-((S)-3-(cyanomethyl)-1,4-oxazepan-4-yl)-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidine]-8-carbonitrile ::US20260022132, Compound 522a	GTPase KRas [G12V]	Homo sapiens			 12.0						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436834	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436834&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493585	439658463							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212039	CN(C)C(=O)c1cc2n(n1)CCCN(c1nc(OC[C@@H]3C[C@@H](F)CN3C)nc3c1COC1(CCCc4ccc(N)c(C#N)c41)C3)C2	InChI=1S/C33H40FN9O3/c1-40(2)31(44)27-13-22-17-42(10-5-11-43(22)39-27)30-25-19-46-33(9-4-6-20-7-8-26(36)24(15-35)29(20)33)14-28(25)37-32(38-30)45-18-23-12-21(34)16-41(23)3/h7-8,13,21,23H,4-6,9-12,14,16-19,36H2,1-3H3	JPQDJGWINKHDKL-UHFFFAOYSA-N	436835	5-(7-Amino-8-cyano-2'-(((2S,4R)-4-fluoro-1-methylpyrrolidin-2-yl)methoxy)-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidin]-4'-yl)-N,N-dimethyl-5,6,7,8-tetrahydro-4H-pyrazolo[1,5-a][1,4]diazepine-2-carboxamide ::US20260022132, Compound 523a	GTPase KRas [G12V]	Homo sapiens			 1.60						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436835	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436835&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134494020	439658464							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212040	CN1CCC[C@H]1COc1nc2c(c(N3CCCOCC3)n1)COC1(CCCc3ccc(N)c(C#N)c31)C2	InChI=1S/C28H36N6O3/c1-33-10-3-6-20(33)17-36-27-31-24-15-28(9-2-5-19-7-8-23(30)21(16-29)25(19)28)37-18-22(24)26(32-27)34-11-4-13-35-14-12-34/h7-8,20H,2-6,9-15,17-18,30H2,1H3	CHJBJULDLGVBRF-UHFFFAOYSA-N	436836	7-Amino-2'-(((S)-1-methylpyrrolidin-2-yl)methoxy)-4'-(1,4-oxazepan-4-yl)-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidine]-8-carbonitrile ::US20260022132, Compound 524a	GTPase KRas [G12V]	Homo sapiens			 86.0						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436836	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436836&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493723	439658465							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212041	CN1CC[C@@H](COc2nc3c(c(N4CCCOCC4)n2)COC2(CCCc4ccc(N)c(C#N)c42)C3)C1	InChI=1S/C28H36N6O3/c1-33-10-7-19(16-33)17-36-27-31-24-14-28(8-2-4-20-5-6-23(30)21(15-29)25(20)28)37-18-22(24)26(32-27)34-9-3-12-35-13-11-34/h5-6,19H,2-4,7-14,16-18,30H2,1H3	VPQDFNIFBIBEKF-UHFFFAOYSA-N	436837	7-Amino-2'-(((R)-1-methylpyrrolidin-3-yl)methoxy)-4'-(1,4-oxazepan-4-yl)-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidine]-8-carbonitrile ::US20260022132, Compound 525a	GTPase KRas [G12V]	Homo sapiens			 880						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436837	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436837&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134494030	439658466							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212042	CN(C)C(=O)c1cc2n(n1)CCCN(c1nc(OC[C@]3(C)CCCN3C)nc3c1COC1(CCCc4ccc(N)c(C#N)c41)C3)C2	InChI=1S/C34H43N9O3/c1-33(11-6-13-41(33)4)21-45-32-37-28-17-34(12-5-8-22-9-10-26(36)24(18-35)29(22)34)46-20-25(28)30(38-32)42-14-7-15-43-23(19-42)16-27(39-43)31(44)40(2)3/h9-10,16H,5-8,11-15,17,19-21,36H2,1-4H3	RMXYCKKQCUDHSQ-UHFFFAOYSA-N	436838	5-(7-amino-8-cyano-2'-(((S)-1,2-dimethylpyrrolidin-2-yl)methoxy)-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidin]-4'-yl)-N,N-dimethyl-5,6,7,8-tetrahydro-4H-pyrazolo[1,5-a][1,4]diazepine-2-carboxamide ::US20260022132, Compound 526a	GTPase KRas [G12V]	Homo sapiens			 2.50						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436838	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436838&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493584	439658467							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212043	CN(C)C(=O)c1cc2n(n1)CCCN(c1nc(OC[C@]3(C)CCCN3C)nc3c1CO[C@]1(CCCc4ccc(N)c(C#N)c41)C3)C2	InChI=1S/C34H43N9O3/c1-33(11-6-13-41(33)4)21-45-32-37-28-17-34(12-5-8-22-9-10-26(36)24(18-35)29(22)34)46-20-25(28)30(38-32)42-14-7-15-43-23(19-42)16-27(39-43)31(44)40(2)3/h9-10,16H,5-8,11-15,17,19-21,36H2,1-4H3	RMXYCKKQCUDHSQ-UHFFFAOYSA-N	436839	US20260022132, Compound 526b	GTPase KRas [G12V]	Homo sapiens			>5000						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436839	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436839&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493812	439658468							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212044	CN(C)C(=O)c1cc2n(n1)CCCN(c1nc(OC[C@]3(C)CCCN3C)nc3c1CO[C@@]1(CCCc4ccc(N)c(C#N)c41)C3)C2	InChI=1S/C34H43N9O3/c1-33(11-6-13-41(33)4)21-45-32-37-28-17-34(12-5-8-22-9-10-26(36)24(18-35)29(22)34)46-20-25(28)30(38-32)42-14-7-15-43-23(19-42)16-27(39-43)31(44)40(2)3/h9-10,16H,5-8,11-15,17,19-21,36H2,1-4H3	RMXYCKKQCUDHSQ-UHFFFAOYSA-N	436840	US20260022132, Compound 526c	GTPase KRas [G12V]	Homo sapiens			 2.10						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436840	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436840&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493786	439658469							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212045	CN(C)C(=O)c1cc2n(n1)CCCN(c1nc(OC[C@]3(C)CCCN3C)nc3c1CO[C@@]1(CCCc4ccc(N)c(C#N)c41)C3)C2	InChI=1S/C34H43N9O3/c1-33(11-6-13-41(33)4)21-45-32-37-28-17-34(12-5-8-22-9-10-26(36)24(18-35)29(22)34)46-20-25(28)30(38-32)42-14-7-15-43-23(19-42)16-27(39-43)31(44)40(2)3/h9-10,16H,5-8,11-15,17,19-21,36H2,1-4H3	RMXYCKKQCUDHSQ-UHFFFAOYSA-N	436840	US20260022132, Compound 526c	GTPase KRas [G12V]	Homo sapiens			 19.0						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436840	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436840&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493786	439658469							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212046	C[C@H](Oc1nc2c(c(N3CCCn4nc(C(=O)N(C)C)cc4C3)n1)CO[C@@]1(CCCc3ccc(N)c(C#N)c31)C2)[C@@H]1CCCN1C	InChI=1S/C34H43N9O3/c1-21(29-9-6-13-41(29)4)46-33-37-28-17-34(12-5-8-22-10-11-26(36)24(18-35)30(22)34)45-20-25(28)31(38-33)42-14-7-15-43-23(19-42)16-27(39-43)32(44)40(2)3/h10-11,16,21,29H,5-9,12-15,17,19-20,36H2,1-4H3	AWPLGPZJDDZEDE-UHFFFAOYSA-N	436841	5-((S*)-7-amino-8-cyano-2'-((S)-1-((S)-1-methylpyrrolidin-2-yl)ethoxy)-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidin]-4'-yl)-N,N-dimethyl-5,6,7,8-tetrahydro-4H-pyrazolo[1,5-a][1,4]diazepine-2-carboxamide ::US20260022132, Compound 527a	GTPase KRas [G12V]	Homo sapiens			 610						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436841	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436841&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493880	439658470							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212047	N#Cc1c(N)ccc2c1[C@]1(CCC2)Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc(N3CCOCC(c4ncco4)C3)c2CO1	InChI=1S/C33H38FN7O4/c34-23-13-32(6-2-9-41(32)17-23)20-44-31-38-27-14-33(7-1-3-21-4-5-26(36)24(15-35)28(21)33)45-19-25(27)29(39-31)40-10-12-42-18-22(16-40)30-37-8-11-43-30/h4-5,8,11,22-23H,1-3,6-7,9-10,12-14,16-20,36H2	FIPNMLYNBLKHOA-UHFFFAOYSA-N	436842	US20260022132, Compound 528a	GTPase KRas [G12V]	Homo sapiens			 1.50						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436842	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436842&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493848	439658471							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212048	N#Cc1c(N)ccc2c1[C@]1(CCC2)Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc(N3CCOCC(c4ncco4)C3)c2CO1	InChI=1S/C33H38FN7O4/c34-23-13-32(6-2-9-41(32)17-23)20-44-31-38-27-14-33(7-1-3-21-4-5-26(36)24(15-35)28(21)33)45-19-25(27)29(39-31)40-10-12-42-18-22(16-40)30-37-8-11-43-30/h4-5,8,11,22-23H,1-3,6-7,9-10,12-14,16-20,36H2	FIPNMLYNBLKHOA-UHFFFAOYSA-N	436842	US20260022132, Compound 528a	GTPase KRas [G12V]	Homo sapiens			 16.0						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436842	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436842&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493848	439658471							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212049	Cc1ncc(C2COCCN(c3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc4c3CO[C@@]3(CCCc5ccc(N)c(C#N)c53)C4)C2)o1	InChI=1S/C34H40FN7O4/c1-21-38-15-29(46-21)23-16-41(10-11-43-18-23)31-26-19-45-34(8-2-4-22-5-6-27(37)25(14-36)30(22)34)13-28(26)39-32(40-31)44-20-33-7-3-9-42(33)17-24(35)12-33/h5-6,15,23-24H,2-4,7-13,16-20,37H2,1H3	SNPVVKNQLHPPOT-UHFFFAOYSA-N	436843	(S)-7-Amino-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-4'-((SR)-6-(2-methyloxazol-5-yl)-1,4-oxazepan-4-yl)-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidine]-8-carbonitrile ::US20260022132, Compound 529a	GTPase KRas [G12V]	Homo sapiens			 6.30						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436843	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436843&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493734	439658472							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212050	Cc1ncc(C2COCCN(c3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc4c3CO[C@@]3(CCCc5ccc(N)c(C#N)c53)C4)C2)o1	InChI=1S/C34H40FN7O4/c1-21-38-15-29(46-21)23-16-41(10-11-43-18-23)31-26-19-45-34(8-2-4-22-5-6-27(37)25(14-36)30(22)34)13-28(26)39-32(40-31)44-20-33-7-3-9-42(33)17-24(35)12-33/h5-6,15,23-24H,2-4,7-13,16-20,37H2,1H3	SNPVVKNQLHPPOT-UHFFFAOYSA-N	436843	(S)-7-Amino-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-4'-((SR)-6-(2-methyloxazol-5-yl)-1,4-oxazepan-4-yl)-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidine]-8-carbonitrile ::US20260022132, Compound 529a	GTPase KRas [G12V]	Homo sapiens			 70.0						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436843	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436843&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493734	439658472							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212051	Cc1c(C(=O)N(C)C)nn2c1CN(c1nc(OC[C@@]34CCCN3C[C@H](F)C4)nc3c1CO[C@@]1(CC[C@H](C)c4ccc(N)c(C#N)c41)C3)CCC2	InChI=1S/C37H46FN9O3/c1-22-9-11-37(31-25(22)7-8-28(40)26(31)17-39)16-29-27(20-50-37)33(42-35(41-29)49-21-36-10-5-13-46(36)18-24(38)15-36)45-12-6-14-47-30(19-45)23(2)32(43-47)34(48)44(3)4/h7-8,22,24H,5-6,9-16,18-21,40H2,1-4H3	RVLLWXQYWDCEOI-UHFFFAOYSA-N	436844	US20260022132, Compound 530a	GTPase KRas [G12V]	Homo sapiens			 0.023						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436844	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436844&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493876	439658473							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212052	Cc1c(C(=O)N(C)C)nn2c1CN(c1nc(OC[C@@]34CCCN3C[C@H](F)C4)nc3c1CO[C@@]1(CC[C@H](C)c4ccc(N)c(C#N)c41)C3)CCC2	InChI=1S/C37H46FN9O3/c1-22-9-11-37(31-25(22)7-8-28(40)26(31)17-39)16-29-27(20-50-37)33(42-35(41-29)49-21-36-10-5-13-46(36)18-24(38)15-36)45-12-6-14-47-30(19-45)23(2)32(43-47)34(48)44(3)4/h7-8,22,24H,5-6,9-16,18-21,40H2,1-4H3	RVLLWXQYWDCEOI-UHFFFAOYSA-N	436844	US20260022132, Compound 530a	GTPase KRas [G12V]	Homo sapiens			 0.046						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436844	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436844&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493876	439658473							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212053	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCCn5nc(C(=O)N(C)C)c(F)c5C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C36H43F2N9O3/c1-21-8-10-36(29-23(21)6-7-26(40)24(29)16-39)15-27-25(19-50-36)32(42-34(41-27)49-20-35-9-4-12-46(35)17-22(37)14-35)45-11-5-13-47-28(18-45)30(38)31(43-47)33(48)44(2)3/h6-7,21-22H,4-5,8-15,17-20,40H2,1-3H3	DXCCUIKJCGUYNI-UHFFFAOYSA-N	436845	US20260022132, Compound 531a	GTPase KRas [G12V]	Homo sapiens			 0.020						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436845	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436845&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493582	439658474							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212054	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCCn5nc(C(=O)N(C)C)c(F)c5C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C36H43F2N9O3/c1-21-8-10-36(29-23(21)6-7-26(40)24(29)16-39)15-27-25(19-50-36)32(42-34(41-27)49-20-35-9-4-12-46(35)17-22(37)14-35)45-11-5-13-47-28(18-45)30(38)31(43-47)33(48)44(2)3/h6-7,21-22H,4-5,8-15,17-20,40H2,1-3H3	DXCCUIKJCGUYNI-UHFFFAOYSA-N	436845	US20260022132, Compound 531a	GTPase KRas [G12V]	Homo sapiens			 0.031						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436845	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436845&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493582	439658474							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212055	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCOC[C@@H](n5cccn5)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C34H41FN8O3/c1-22-6-8-34(30-25(22)4-5-28(37)26(30)16-36)15-29-27(20-46-34)31(41-12-13-44-19-24(18-41)43-11-3-9-38-43)40-32(39-29)45-21-33-7-2-10-42(33)17-23(35)14-33/h3-5,9,11,22-24H,2,6-8,10,12-15,17-21,37H2,1H3	UUOHEFJLIBXQFE-UHFFFAOYSA-N	436846	US20260022132, Compound 532a	GTPase KRas [G12V]	Homo sapiens			 0.065						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436846	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436846&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493701	439658475							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212056	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCOC[C@@H](n5cccn5)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C34H41FN8O3/c1-22-6-8-34(30-25(22)4-5-28(37)26(30)16-36)15-29-27(20-46-34)31(41-12-13-44-19-24(18-41)43-11-3-9-38-43)40-32(39-29)45-21-33-7-2-10-42(33)17-23(35)14-33/h3-5,9,11,22-24H,2,6-8,10,12-15,17-21,37H2,1H3	UUOHEFJLIBXQFE-UHFFFAOYSA-N	436846	US20260022132, Compound 532a	GTPase KRas [G12V]	Homo sapiens			 0.750						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436846	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436846&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493701	439658475							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212057	N#C[C@]1(F)CCCN(c2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc3c2CO[C@@]2(CCCc4ccc(N)cc42)C3)CC1	InChI=1S/C31H38F2N6O2/c32-22-15-30(8-3-12-39(30)17-22)20-40-28-36-26-16-31(9-1-4-21-5-6-23(35)14-25(21)31)41-18-24(26)27(37-28)38-11-2-7-29(33,19-34)10-13-38/h5-6,14,22H,1-4,7-13,15-18,20,35H2	BZHILTOGSVYOSA-UHFFFAOYSA-N	436847	US20260022132, Compound 533a	GTPase KRas [G12V]	Homo sapiens			 120						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436847	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436847&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493755	439658476							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212058	N#Cc1c(N)ccc2c1[C@]1(CCC2)Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc(N3CCC3)c2CO1	InChI=1S/C28H33FN6O2/c29-19-12-27(7-2-11-35(27)15-19)17-36-26-32-23-13-28(37-16-21(23)25(33-26)34-9-3-10-34)8-1-4-18-5-6-22(31)20(14-30)24(18)28/h5-6,19H,1-4,7-13,15-17,31H2	CZASIUIKRAFWCJ-UHFFFAOYSA-N	436848	US20260022132, Compound 534a	GTPase KRas [G12V]	Homo sapiens			 6.70						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436848	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436848&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134494041	439658477							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212059	N#Cc1c(N)ccc2c1[C@]1(CCC2)Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc(N3CCC3)c2CO1	InChI=1S/C28H33FN6O2/c29-19-12-27(7-2-11-35(27)15-19)17-36-26-32-23-13-28(37-16-21(23)25(33-26)34-9-3-10-34)8-1-4-18-5-6-22(31)20(14-30)24(18)28/h5-6,19H,1-4,7-13,15-17,31H2	CZASIUIKRAFWCJ-UHFFFAOYSA-N	436848	US20260022132, Compound 534a	GTPase KRas [G12V]	Homo sapiens			 46.0						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436848	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436848&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134494041	439658477							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212060	C[C@H](Oc1nc2c(c(N3CCCOCC3)n1)CO[C@@]1(CCCc3ccc(N)c(C#N)c31)C2)[C@@H]1CCCN1C	InChI=1S/C29H38N6O3/c1-19(25-7-4-11-34(25)2)38-28-32-24-16-29(10-3-6-20-8-9-23(31)21(17-30)26(20)29)37-18-22(24)27(33-28)35-12-5-14-36-15-13-35/h8-9,19,25H,3-7,10-16,18,31H2,1-2H3	HZLMUAPEBHJZQB-UHFFFAOYSA-N	437152	US20260022132, Compound 535a	GTPase KRas [G12V]	Homo sapiens			>5000						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437152	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437152&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493901	439658781							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212061	CN(C)C(=O)c1nn2c(c1Cl)CN(c1nc(OC[C@@]34CCCN3CC(F)C4)nc3c1COC1(CCCc4cc(F)c(N)c(C#N)c41)C3)CCC2	InChI=1S/C35H40ClF2N9O3/c1-44(2)32(48)30-28(36)26-17-45(9-5-11-47(26)43-30)31-23-18-50-35(8-3-6-20-12-24(38)29(40)22(15-39)27(20)35)14-25(23)41-33(42-31)49-19-34-7-4-10-46(34)16-21(37)13-34/h12,21H,3-11,13-14,16-19,40H2,1-2H3	AUTHDPSDKALYBR-UHFFFAOYSA-N	436849	US20260022132, Compound 536a	GTPase KRas [G12V]	Homo sapiens			 0.240						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436849	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436849&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493576	439658478							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212062	CN(C)C(=O)c1nn2c(c1Cl)CN(c1nc(OC[C@@]34CCCN3CC(F)C4)nc3c1COC1(CCCc4cc(F)c(N)c(C#N)c41)C3)CCC2	InChI=1S/C35H40ClF2N9O3/c1-44(2)32(48)30-28(36)26-17-45(9-5-11-47(26)43-30)31-23-18-50-35(8-3-6-20-12-24(38)29(40)22(15-39)27(20)35)14-25(23)41-33(42-31)49-19-34-7-4-10-46(34)16-21(37)13-34/h12,21H,3-11,13-14,16-19,40H2,1-2H3	AUTHDPSDKALYBR-UHFFFAOYSA-N	436849	US20260022132, Compound 536a	GTPase KRas [G12V]	Homo sapiens			 2.70						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436849	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436849&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493576	439658478							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212063	CN(C)C(=O)c1nn2c(c1Cl)CN(c1nc(OC[C@@]34CCCN3C[C@H](F)C4)nc3c1CO[C@]1(CCCc4cc(F)c(N)c(C#N)c41)C3)CCC2	InChI=1S/C35H40ClF2N9O3/c1-44(2)32(48)30-28(36)26-17-45(9-5-11-47(26)43-30)31-23-18-50-35(8-3-6-20-12-24(38)29(40)22(15-39)27(20)35)14-25(23)41-33(42-31)49-19-34-7-4-10-46(34)16-21(37)13-34/h12,21H,3-11,13-14,16-19,40H2,1-2H3	AUTHDPSDKALYBR-UHFFFAOYSA-N	436850	US20260022132, Compound 536b	GTPase KRas [G12V]	Homo sapiens			>5000						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436850	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436850&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493793	439658479							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212064	CN(C)C(=O)c1nn2c(c1Cl)CN(c1nc(OC[C@@]34CCCN3C[C@H](F)C4)nc3c1CO[C@@]1(CCCc4cc(F)c(N)c(C#N)c41)C3)CCC2	InChI=1S/C35H40ClF2N9O3/c1-44(2)32(48)30-28(36)26-17-45(9-5-11-47(26)43-30)31-23-18-50-35(8-3-6-20-12-24(38)29(40)22(15-39)27(20)35)14-25(23)41-33(42-31)49-19-34-7-4-10-46(34)16-21(37)13-34/h12,21H,3-11,13-14,16-19,40H2,1-2H3	AUTHDPSDKALYBR-UHFFFAOYSA-N	436851	US20260022132, Compound 536c	GTPase KRas [G12V]	Homo sapiens			 0.240						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436851	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436851&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134417391	439658480							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212065	CN(C)C(=O)c1nn2c(c1Cl)CN(c1nc(OC[C@@]34CCCN3C[C@H](F)C4)nc3c1CO[C@@]1(CCCc4cc(F)c(N)c(C#N)c41)C3)CCC2	InChI=1S/C35H40ClF2N9O3/c1-44(2)32(48)30-28(36)26-17-45(9-5-11-47(26)43-30)31-23-18-50-35(8-3-6-20-12-24(38)29(40)22(15-39)27(20)35)14-25(23)41-33(42-31)49-19-34-7-4-10-46(34)16-21(37)13-34/h12,21H,3-11,13-14,16-19,40H2,1-2H3	AUTHDPSDKALYBR-UHFFFAOYSA-N	436851	US20260022132, Compound 536c	GTPase KRas [G12V]	Homo sapiens			 2.50						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436851	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436851&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134417391	439658480							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212066	CN(C)C1CN(c2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc3c2CO[C@@]2(CCCc4ccc(N)c(C#N)c42)C3)C1	InChI=1S/C30H38FN7O2/c1-36(2)21-15-37(16-21)27-23-17-40-30(9-3-5-19-6-7-24(33)22(13-32)26(19)30)12-25(23)34-28(35-27)39-18-29-8-4-10-38(29)14-20(31)11-29/h6-7,20-21H,3-5,8-12,14-18,33H2,1-2H3	XYZWGXRBRVSJSL-UHFFFAOYSA-N	436852	US20260022132, Compound 537a	GTPase KRas [G12V]	Homo sapiens			>5000						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436852	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436852&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493716	439658481							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212067	N#Cc1c(N)ccc2c1[C@]1(CCC2)Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc(N3CC4(CCOC4)C3)c2CO1	InChI=1S/C31H37FN6O3/c32-21-11-30(6-2-9-38(30)14-21)19-40-28-35-25-12-31(7-1-3-20-4-5-24(34)22(13-33)26(20)31)41-15-23(25)27(36-28)37-16-29(17-37)8-10-39-18-29/h4-5,21H,1-3,6-12,14-19,34H2	QMUAGYMYEOURIL-UHFFFAOYSA-N	436853	US20260022132, Compound 538a	GTPase KRas [G12V]	Homo sapiens			 240						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436853	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436853&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493704	439658482							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212068	N#Cc1c(N)ccc2c1[C@]1(CCC2)Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc(N3CC(N4CCOCC4)C3)c2CO1	InChI=1S/C32H40FN7O3/c33-22-13-31(6-2-8-40(31)16-22)20-42-30-36-27-14-32(7-1-3-21-4-5-26(35)24(15-34)28(21)32)43-19-25(27)29(37-30)39-17-23(18-39)38-9-11-41-12-10-38/h4-5,22-23H,1-3,6-14,16-20,35H2	VVSFEJURONAHAL-UHFFFAOYSA-N	436854	US20260022132, Compound 539a	GTPase KRas [G12V]	Homo sapiens			>5000						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436854	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436854&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493592	439658483							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212069	N#Cc1c(N)ccc2c1[C@]1(CCC2)Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc(N3CC(F)C3)c2CO1	InChI=1S/C28H32F2N6O2/c29-18-9-27(6-2-8-36(27)14-18)16-37-26-33-23-10-28(38-15-21(23)25(34-26)35-12-19(30)13-35)7-1-3-17-4-5-22(32)20(11-31)24(17)28/h4-5,18-19H,1-3,6-10,12-16,32H2	SYEFMKCHHPCPPV-UHFFFAOYSA-N	436855	US20260022132, Compound 540a	GTPase KRas [G12V]	Homo sapiens			 7.20						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436855	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436855&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493761	439658484							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212070	N#Cc1c(N)ccc2c1[C@]1(CCC2)Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc(N3CC(n4cccn4)C3)c2CO1	InChI=1S/C31H35FN8O2/c32-21-12-30(7-2-10-39(30)15-21)19-41-29-36-26-13-31(8-1-4-20-5-6-25(34)23(14-33)27(20)31)42-18-24(26)28(37-29)38-16-22(17-38)40-11-3-9-35-40/h3,5-6,9,11,21-22H,1-2,4,7-8,10,12-13,15-19,34H2	MFXUATBJLKPMRN-UHFFFAOYSA-N	436856	US20260022132, Compound 541a	GTPase KRas [G12V]	Homo sapiens			 110						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436856	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436856&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493765	439658485							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212071	N#Cc1c(N)ccc2c1[C@]1(CCC2)Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc(N3CC(c4cccnc4)C3)c2CO1	InChI=1S/C33H36FN7O2/c34-24-12-32(8-3-11-41(32)18-24)20-42-31-38-28-13-33(9-1-4-21-6-7-27(36)25(14-35)29(21)33)43-19-26(28)30(39-31)40-16-23(17-40)22-5-2-10-37-15-22/h2,5-7,10,15,23-24H,1,3-4,8-9,11-13,16-20,36H2	NQRLIINXYHCPFI-UHFFFAOYSA-N	436857	US20260022132, Compound 542a	GTPase KRas [G12V]	Homo sapiens			 3.40						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436857	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436857&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493735	439658486							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212072	N#Cc1c(N)ccc2c1[C@]1(CCC2)Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc(N3CC(c4cccnc4)C3)c2CO1	InChI=1S/C33H36FN7O2/c34-24-12-32(8-3-11-41(32)18-24)20-42-31-38-28-13-33(9-1-4-21-6-7-27(36)25(14-35)29(21)33)43-19-26(28)30(39-31)40-16-23(17-40)22-5-2-10-37-15-22/h2,5-7,10,15,23-24H,1,3-4,8-9,11-13,16-20,36H2	NQRLIINXYHCPFI-UHFFFAOYSA-N	436857	US20260022132, Compound 542a	GTPase KRas [G12V]	Homo sapiens			 45.0						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436857	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436857&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493735	439658486							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212073	N#Cc1c(N)ccc2c1[C@]1(CCC2)Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc(N3CC(O)(c4ccccc4)C3)c2CO1	InChI=1S/C34H37FN6O3/c35-24-14-32(11-5-13-41(32)17-24)21-43-31-38-28-15-34(12-4-6-22-9-10-27(37)25(16-36)29(22)34)44-18-26(28)30(39-31)40-19-33(42,20-40)23-7-2-1-3-8-23/h1-3,7-10,24,42H,4-6,11-15,17-21,37H2	ZTUMYVAWEMCDRU-UHFFFAOYSA-N	436859	US20260022132, Compound 544a	GTPase KRas [G12V]	Homo sapiens			 340						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436859	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436859&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493882	439658488							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212074	CN1C[C@H](F)C[C@H]1COc1nc2c(c(N3CCCOCC3)n1)CO[C@@]1(CCCc3ccc(N)c(C#N)c31)C2	InChI=1S/C28H35FN6O3/c1-34-15-19(29)12-20(34)16-37-27-32-24-13-28(7-2-4-18-5-6-23(31)21(14-30)25(18)28)38-17-22(24)26(33-27)35-8-3-10-36-11-9-35/h5-6,19-20H,2-4,7-13,15-17,31H2,1H3	REUHQZONBXOUNV-UHFFFAOYSA-N	437153	US20260022132, Compound 545a	GTPase KRas [G12V]	Homo sapiens			 45.0						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437153	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437153&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493837	439658782							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212075	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4CC(F)(F)C5)nc(N4CCCn5nc(C(=O)N(C)C)c(Cl)c5C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C36H42ClF2N9O3/c1-21-8-10-35(28-22(21)6-7-25(41)23(28)15-40)14-26-24(17-51-35)31(43-33(42-26)50-20-34-9-4-12-47(34)19-36(38,39)18-34)46-11-5-13-48-27(16-46)29(37)30(44-48)32(49)45(2)3/h6-7,21H,4-5,8-14,16-20,41H2,1-3H3	NWHSOFHXOXFDFX-UHFFFAOYSA-N	436860	US20260022132, Compound 546a	GTPase KRas [G12V]	Homo sapiens			 0.100						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436860	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436860&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493752	439658489							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212076	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4CC(F)(F)C5)nc(N4CCCn5nc(C(=O)N(C)C)c(Cl)c5C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C36H42ClF2N9O3/c1-21-8-10-35(28-22(21)6-7-25(41)23(28)15-40)14-26-24(17-51-35)31(43-33(42-26)50-20-34-9-4-12-47(34)19-36(38,39)18-34)46-11-5-13-48-27(16-46)29(37)30(44-48)32(49)45(2)3/h6-7,21H,4-5,8-14,16-20,41H2,1-3H3	NWHSOFHXOXFDFX-UHFFFAOYSA-N	436860	US20260022132, Compound 546a	GTPase KRas [G12V]	Homo sapiens			 0.100						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436860	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436860&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493752	439658489							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212077	N#Cc1c(N)ccc2c1[C@]1(CCC2)Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc(N3CC4(CCO4)C3)c2CO1	InChI=1S/C30H35FN6O3/c31-20-11-28(6-2-9-37(28)14-20)18-38-27-34-24-12-30(7-1-3-19-4-5-23(33)21(13-32)25(19)30)40-15-22(24)26(35-27)36-16-29(17-36)8-10-39-29/h4-5,20H,1-3,6-12,14-18,33H2	QUOAGSMYZWIWDM-UHFFFAOYSA-N	436861	US20260022132, Compound 547a	GTPase KRas [G12V]	Homo sapiens			 180						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436861	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436861&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490024	439658490							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212078	N#Cc1c(N)ccc2c1[C@]1(CCC2)Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc(N3CC4(C3)CC4(F)F)c2CO1	InChI=1S/C30H33F3N6O2/c31-19-9-28(6-2-8-39(28)12-19)17-40-26-36-23-10-29(7-1-3-18-4-5-22(35)20(11-34)24(18)29)41-13-21(23)25(37-26)38-15-27(16-38)14-30(27,32)33/h4-5,19H,1-3,6-10,12-17,35H2	RQILTWDZEGJRDA-UHFFFAOYSA-N	436862	US20260022132, Compound 548a	GTPase KRas [G12V]	Homo sapiens			 260						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436862	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436862&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490027	439658491							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212079	CC(C)(O)C1CN(c2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc3c2CO[C@@]2(CCCc4ccc(N)c(C#N)c42)C3)C1	InChI=1S/C31H39FN6O3/c1-29(2,39)20-14-37(15-20)27-23-17-41-31(9-3-5-19-6-7-24(34)22(13-33)26(19)31)12-25(23)35-28(36-27)40-18-30-8-4-10-38(30)16-21(32)11-30/h6-7,20-21,39H,3-5,8-12,14-18,34H2,1-2H3	BONDOGADDTYJNO-UHFFFAOYSA-N	436863	US20260022132, Compound 549a	GTPase KRas [G12V]	Homo sapiens			>5000						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436863	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436863&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490025	439658492							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212080	N#Cc1c(N)ccc2c1[C@]1(CCC2)Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc(N3CCC34COC4)c2CO1	InChI=1S/C30H35FN6O3/c31-20-11-28(6-2-9-36(28)14-20)18-39-27-34-24-12-30(7-1-3-19-4-5-23(33)21(13-32)25(19)30)40-15-22(24)26(35-27)37-10-8-29(37)16-38-17-29/h4-5,20H,1-3,6-12,14-18,33H2	BHHVCVSMRRLGKB-UHFFFAOYSA-N	436864	(S)-7-Amino-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-4'-(6-oxa-1-azaspiro[3.3]heptan-1-yl)-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidine]-8-carbonitrile ::US20260022132, Compound 550a	GTPase KRas [G12V]	Homo sapiens			 0.270						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436864	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436864&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490026	439658493							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212081	N#Cc1c(N)ccc2c1[C@]1(CCC2)Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc(N3CCC34COC4)c2CO1	InChI=1S/C30H35FN6O3/c31-20-11-28(6-2-9-36(28)14-20)18-39-27-34-24-12-30(7-1-3-19-4-5-23(33)21(13-32)25(19)30)40-15-22(24)26(35-27)37-10-8-29(37)16-38-17-29/h4-5,20H,1-3,6-12,14-18,33H2	BHHVCVSMRRLGKB-UHFFFAOYSA-N	436864	(S)-7-Amino-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-4'-(6-oxa-1-azaspiro[3.3]heptan-1-yl)-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidine]-8-carbonitrile ::US20260022132, Compound 550a	GTPase KRas [G12V]	Homo sapiens			 2.60						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436864	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436864&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490026	439658493							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212082	N#Cc1c(N)ccc2c1[C@]1(CCC2)Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc(N3CC4(CCNC4=O)C3)c2CO1	InChI=1S/C31H36FN7O3/c32-20-11-30(6-2-10-39(30)14-20)18-41-28-36-24-12-31(7-1-3-19-4-5-23(34)21(13-33)25(19)31)42-15-22(24)26(37-28)38-16-29(17-38)8-9-35-27(29)40/h4-5,20H,1-3,6-12,14-18,34H2,(H,35,40)	QXSDUHSHRKHWBX-UHFFFAOYSA-N	436865	US20260022132, Compound 551a	GTPase KRas [G12V]	Homo sapiens			 110						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436865	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436865&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490028	439658494							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212083	N#Cc1c(N)ccc2c1[C@]1(CCC2)Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc(N3CC4(CNC(=O)C4)C3)c2CO1	InChI=1S/C31H36FN7O3/c32-20-9-30(6-2-8-39(30)13-20)18-41-28-36-24-10-31(7-1-3-19-4-5-23(34)21(12-33)26(19)31)42-14-22(24)27(37-28)38-16-29(17-38)11-25(40)35-15-29/h4-5,20H,1-3,6-11,13-18,34H2,(H,35,40)	YJWXKEOFTYLBJU-UHFFFAOYSA-N	436866	US20260022132, Compound 552a	GTPase KRas [G12V]	Homo sapiens			 20.0						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436866	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436866&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134494044	439658495							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212084	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCC4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C29H35FN6O2/c1-18-6-8-29(25-20(18)4-5-23(32)21(25)14-31)13-24-22(16-38-29)26(35-9-3-10-35)34-27(33-24)37-17-28-7-2-11-36(28)15-19(30)12-28/h4-5,18-19H,2-3,6-13,15-17,32H2,1H3	BZQAJGJCZFNMAQ-UHFFFAOYSA-N	436867	US20260022132, Compound 553a	GTPase KRas [G12V]	Homo sapiens			 0.750						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436867	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436867&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134494048	439658496							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212085	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCC4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C29H35FN6O2/c1-18-6-8-29(25-20(18)4-5-23(32)21(25)14-31)13-24-22(16-38-29)26(35-9-3-10-35)34-27(33-24)37-17-28-7-2-11-36(28)15-19(30)12-28/h4-5,18-19H,2-3,6-13,15-17,32H2,1H3	BZQAJGJCZFNMAQ-UHFFFAOYSA-N	436867	US20260022132, Compound 553a	GTPase KRas [G12V]	Homo sapiens			 8.80						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436867	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436867&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134494048	439658496							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212086	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCCC5(C4)NC(=O)NC5=O)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C33H39FN8O4/c1-19-6-9-33(26-21(19)4-5-24(36)22(26)14-35)13-25-23(16-46-33)27(41-10-3-8-32(17-41)28(43)39-29(44)40-32)38-30(37-25)45-18-31-7-2-11-42(31)15-20(34)12-31/h4-5,19-20H,2-3,6-13,15-18,36H2,1H3,(H2,39,40,43,44)	JJAZBFDHKAQEQK-UHFFFAOYSA-N	436868	US20260022132, Compound 554a	GTPase KRas [G12V]	Homo sapiens			 0.460						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436868	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436868&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493878	439658497							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212087	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCCC5(C4)NC(=O)NC5=O)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C33H39FN8O4/c1-19-6-9-33(26-21(19)4-5-24(36)22(26)14-35)13-25-23(16-46-33)27(41-10-3-8-32(17-41)28(43)39-29(44)40-32)38-30(37-25)45-18-31-7-2-11-42(31)15-20(34)12-31/h4-5,19-20H,2-3,6-13,15-18,36H2,1H3,(H2,39,40,43,44)	JJAZBFDHKAQEQK-UHFFFAOYSA-N	436868	US20260022132, Compound 554a	GTPase KRas [G12V]	Homo sapiens			 4.70						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436868	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436868&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493878	439658497							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212088	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCC[C@]5(C4)NC(=O)NC5=O)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C33H39FN8O4/c1-19-6-9-33(26-21(19)4-5-24(36)22(26)14-35)13-25-23(16-46-33)27(41-10-3-8-32(17-41)28(43)39-29(44)40-32)38-30(37-25)45-18-31-7-2-11-42(31)15-20(34)12-31/h4-5,19-20H,2-3,6-13,15-18,36H2,1H3,(H2,39,40,43,44)	JJAZBFDHKAQEQK-UHFFFAOYSA-N	436869	US20260022132, Compound 554b	GTPase KRas [G12V]	Homo sapiens			 0.270						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436869	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436869&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493589	439658498							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212089	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCC[C@]5(C4)NC(=O)NC5=O)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C33H39FN8O4/c1-19-6-9-33(26-21(19)4-5-24(36)22(26)14-35)13-25-23(16-46-33)27(41-10-3-8-32(17-41)28(43)39-29(44)40-32)38-30(37-25)45-18-31-7-2-11-42(31)15-20(34)12-31/h4-5,19-20H,2-3,6-13,15-18,36H2,1H3,(H2,39,40,43,44)	JJAZBFDHKAQEQK-UHFFFAOYSA-N	436869	US20260022132, Compound 554b	GTPase KRas [G12V]	Homo sapiens			 3.30						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436869	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436869&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493589	439658498							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212090	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCC[C@@]5(C4)NC(=O)NC5=O)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C33H39FN8O4/c1-19-6-9-33(26-21(19)4-5-24(36)22(26)14-35)13-25-23(16-46-33)27(41-10-3-8-32(17-41)28(43)39-29(44)40-32)38-30(37-25)45-18-31-7-2-11-42(31)15-20(34)12-31/h4-5,19-20H,2-3,6-13,15-18,36H2,1H3,(H2,39,40,43,44)	JJAZBFDHKAQEQK-UHFFFAOYSA-N	436870	US20260022132, Compound 554c	GTPase KRas [G12V]	Homo sapiens			 0.120						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436870	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436870&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493591	439658499							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212091	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCC[C@@]5(C4)NC(=O)NC5=O)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C33H39FN8O4/c1-19-6-9-33(26-21(19)4-5-24(36)22(26)14-35)13-25-23(16-46-33)27(41-10-3-8-32(17-41)28(43)39-29(44)40-32)38-30(37-25)45-18-31-7-2-11-42(31)15-20(34)12-31/h4-5,19-20H,2-3,6-13,15-18,36H2,1H3,(H2,39,40,43,44)	JJAZBFDHKAQEQK-UHFFFAOYSA-N	436870	US20260022132, Compound 554c	GTPase KRas [G12V]	Homo sapiens			 1.90						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436870	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436870&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493591	439658499							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212092	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC5(C4)CC(C)(O)C5)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C33H41FN6O3/c1-20-6-8-33(27-22(20)4-5-25(36)23(27)12-35)11-26-24(14-43-33)28(39-17-31(18-39)15-30(2,41)16-31)38-29(37-26)42-19-32-7-3-9-40(32)13-21(34)10-32/h4-5,20-21,41H,3,6-11,13-19,36H2,1-2H3	DFEDOQLCCUFRAL-UHFFFAOYSA-N	436871	US20260022132, Compound 555a	GTPase KRas [G12V]	Homo sapiens			 380						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436871	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436871&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493601	439658500							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212093	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCC45COC5)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C31H37FN6O3/c1-19-5-7-31(26-21(19)3-4-24(34)22(26)13-33)12-25-23(15-41-31)27(38-10-8-30(38)16-39-17-30)36-28(35-25)40-18-29-6-2-9-37(29)14-20(32)11-29/h3-4,19-20H,2,5-12,14-18,34H2,1H3	GQGPIAPNFZYKDL-UHFFFAOYSA-N	436872	(1S,4S)-7-Amino-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-4-methyl-4'-(6-oxa-1-azaspiro[3.3]heptan-1-yl)-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidine]-8-carbonitrile ::US20260022132, Compound 556a	GTPase KRas [G12V]	Homo sapiens			 0.048						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436872	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436872&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493750	439658501							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212094	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCC45COC5)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C31H37FN6O3/c1-19-5-7-31(26-21(19)3-4-24(34)22(26)13-33)12-25-23(15-41-31)27(38-10-8-30(38)16-39-17-30)36-28(35-25)40-18-29-6-2-9-37(29)14-20(32)11-29/h3-4,19-20H,2,5-12,14-18,34H2,1H3	GQGPIAPNFZYKDL-UHFFFAOYSA-N	436872	(1S,4S)-7-Amino-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-4-methyl-4'-(6-oxa-1-azaspiro[3.3]heptan-1-yl)-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidine]-8-carbonitrile ::US20260022132, Compound 556a	GTPase KRas [G12V]	Homo sapiens			 0.330						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436872	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436872&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493750	439658501							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212095	C[C@H]1CC[C@@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCC45COC5)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C31H37FN6O3/c1-19-5-7-31(26-21(19)3-4-24(34)22(26)13-33)12-25-23(15-41-31)27(38-10-8-30(38)16-39-17-30)36-28(35-25)40-18-29-6-2-9-37(29)14-20(32)11-29/h3-4,19-20H,2,5-12,14-18,34H2,1H3	GQGPIAPNFZYKDL-UHFFFAOYSA-N	436873	US20260022132, Compound 556b	GTPase KRas [G12V]	Homo sapiens			>500						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436873	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436873&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493600	439658502							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212096	C[C@H]1CC[C@@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCC45COC5)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C31H37FN6O3/c1-19-5-7-31(26-21(19)3-4-24(34)22(26)13-33)12-25-23(15-41-31)27(38-10-8-30(38)16-39-17-30)36-28(35-25)40-18-29-6-2-9-37(29)14-20(32)11-29/h3-4,19-20H,2,5-12,14-18,34H2,1H3	GQGPIAPNFZYKDL-UHFFFAOYSA-N	436873	US20260022132, Compound 556b	GTPase KRas [G12V]	Homo sapiens			>500						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436873	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436873&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493600	439658502							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212097	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC[C@@H]4CO)c3CO2)c2cc(N)ccc21	InChI=1S/C29H38FN5O3/c1-18-5-8-29(24-11-20(31)3-4-22(18)24)13-25-23(16-38-29)26(35-10-6-21(35)15-36)33-27(32-25)37-17-28-7-2-9-34(28)14-19(30)12-28/h3-4,11,18-19,21,36H,2,5-10,12-17,31H2,1H3	ZFBUBXZKZPZQME-UHFFFAOYSA-N	437154	US20260022132, Compound 557a	GTPase KRas [G12V]	Homo sapiens			 71.0						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437154	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437154&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134494098	439658783							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212098	CN1CCC[C@@]1(C)COc1nc2c(c(N3CCCOCC3)n1)CO[C@@]1(CCCc3ccc(N)c(C#N)c31)C2	InChI=1S/C29H38N6O3/c1-28(9-4-11-34(28)2)19-37-27-32-24-16-29(10-3-6-20-7-8-23(31)21(17-30)25(20)29)38-18-22(24)26(33-27)35-12-5-14-36-15-13-35/h7-8H,3-6,9-16,18-19,31H2,1-2H3	FSGMPQQHETYPSH-UHFFFAOYSA-N	436874	US20260022132, Compound 558a	GTPase KRas [G12V]	Homo sapiens			 380						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436874	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436874&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493605	439658503							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212099	N#Cc1c(N)ccc2c1[C@]1(CCC2)Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc(N3CCOC[C@@H](n4cc(F)cn4)C3)c2CO1	InChI=1S/C33H38F2N8O3/c34-22-11-32(6-2-8-42(32)15-22)20-45-31-39-28-12-33(7-1-3-21-4-5-27(37)25(13-36)29(21)33)46-19-26(28)30(40-31)41-9-10-44-18-24(17-41)43-16-23(35)14-38-43/h4-5,14,16,22,24H,1-3,6-12,15,17-20,37H2	UVQFYXICOHIQER-UHFFFAOYSA-N	436875	US20260022132, Compound 559a	GTPase KRas [G12V]	Homo sapiens			 0.560						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436875	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436875&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493590	439658504							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212100	N#Cc1c(N)ccc2c1[C@]1(CCC2)Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc(N3CCOC[C@@H](n4cc(F)cn4)C3)c2CO1	InChI=1S/C33H38F2N8O3/c34-22-11-32(6-2-8-42(32)15-22)20-45-31-39-28-12-33(7-1-3-21-4-5-27(37)25(13-36)29(21)33)46-19-26(28)30(40-31)41-9-10-44-18-24(17-41)43-16-23(35)14-38-43/h4-5,14,16,22,24H,1-3,6-12,15,17-20,37H2	UVQFYXICOHIQER-UHFFFAOYSA-N	436875	US20260022132, Compound 559a	GTPase KRas [G12V]	Homo sapiens			 7.60						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436875	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436875&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493590	439658504							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212101	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC(F)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C29H34F2N6O2/c1-17-5-7-29(25-20(17)3-4-23(33)21(25)11-32)10-24-22(15-39-29)26(36-12-19(31)13-36)35-27(34-24)38-16-28-6-2-8-37(28)14-18(30)9-28/h3-4,17-19H,2,5-10,12-16,33H2,1H3	FVMUTFHUQFSJHZ-UHFFFAOYSA-N	436876	US20260022132, Compound 560a	GTPase KRas [G12V]	Homo sapiens			 0.680						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436876	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436876&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493873	439658505							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212102	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC(F)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C29H34F2N6O2/c1-17-5-7-29(25-20(17)3-4-23(33)21(25)11-32)10-24-22(15-39-29)26(36-12-19(31)13-36)35-27(34-24)38-16-28-6-2-8-37(28)14-18(30)9-28/h3-4,17-19H,2,5-10,12-16,33H2,1H3	FVMUTFHUQFSJHZ-UHFFFAOYSA-N	436876	US20260022132, Compound 560a	GTPase KRas [G12V]	Homo sapiens			 7.50						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436876	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436876&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493873	439658505							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212103	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC(c5cccnc5)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C34H38FN7O2/c1-21-7-9-34(30-25(21)5-6-28(37)26(30)14-36)13-29-27(19-44-34)31(41-16-23(17-41)22-4-2-10-38-15-22)40-32(39-29)43-20-33-8-3-11-42(33)18-24(35)12-33/h2,4-6,10,15,21,23-24H,3,7-9,11-13,16-20,37H2,1H3	DHVLSIYBMYHZRK-UHFFFAOYSA-N	436877	US20260022132, Compound 561a	GTPase KRas [G12V]	Homo sapiens			 0.310						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436877	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436877&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493864	439658506							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212104	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC(c5cccnc5)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C34H38FN7O2/c1-21-7-9-34(30-25(21)5-6-28(37)26(30)14-36)13-29-27(19-44-34)31(41-16-23(17-41)22-4-2-10-38-15-22)40-32(39-29)43-20-33-8-3-11-42(33)18-24(35)12-33/h2,4-6,10,15,21,23-24H,3,7-9,11-13,16-20,37H2,1H3	DHVLSIYBMYHZRK-UHFFFAOYSA-N	436877	US20260022132, Compound 561a	GTPase KRas [G12V]	Homo sapiens			 3.30						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436877	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436877&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493864	439658506							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212105	Cn1cc(C2COCCN(c3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc4c3CO[C@@]3(CCCc5ccc(N)c(C#N)c53)C4)C2)cn1	InChI=1S/C34H41FN8O3/c1-41-16-23(15-38-41)24-17-42(10-11-44-19-24)31-27-20-46-34(8-2-4-22-5-6-28(37)26(14-36)30(22)34)13-29(27)39-32(40-31)45-21-33-7-3-9-43(33)18-25(35)12-33/h5-6,15-16,24-25H,2-4,7-13,17-21,37H2,1H3	VKEBTILTAWAOFQ-UHFFFAOYSA-N	436878	US20260022132, Compound 562a	GTPase KRas [G12V]	Homo sapiens			 5.50						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436878	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436878&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493604	439658507							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212106	Cn1cc(C2COCCN(c3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc4c3CO[C@@]3(CCCc5ccc(N)c(C#N)c53)C4)C2)cn1	InChI=1S/C34H41FN8O3/c1-41-16-23(15-38-41)24-17-42(10-11-44-19-24)31-27-20-46-34(8-2-4-22-5-6-28(37)26(14-36)30(22)34)13-29(27)39-32(40-31)45-21-33-7-3-9-43(33)18-25(35)12-33/h5-6,15-16,24-25H,2-4,7-13,17-21,37H2,1H3	VKEBTILTAWAOFQ-UHFFFAOYSA-N	436878	US20260022132, Compound 562a	GTPase KRas [G12V]	Homo sapiens			 49.0						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436878	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436878&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493604	439658507							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212107	N#Cc1c(N)ccc2c1[C@]1(CCC2)Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc(N3CCOCC(c4nccs4)C3)c2CO1	InChI=1S/C33H38FN7O3S/c34-23-13-32(6-2-9-41(32)17-23)20-43-31-38-27-14-33(7-1-3-21-4-5-26(36)24(15-35)28(21)33)44-19-25(27)29(39-31)40-10-11-42-18-22(16-40)30-37-8-12-45-30/h4-5,8,12,22-23H,1-3,6-7,9-11,13-14,16-20,36H2	OAUJLQRXRHIUAR-UHFFFAOYSA-N	436879	US20260022132, Compound 563a	GTPase KRas [G12V]	Homo sapiens			 0.640						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436879	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436879&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493714	439658508							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212108	N#Cc1c(N)ccc2c1[C@]1(CCC2)Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc(N3CCOCC(c4nccs4)C3)c2CO1	InChI=1S/C33H38FN7O3S/c34-23-13-32(6-2-9-41(32)17-23)20-43-31-38-27-14-33(7-1-3-21-4-5-26(36)24(15-35)28(21)33)44-19-25(27)29(39-31)40-10-11-42-18-22(16-40)30-37-8-12-45-30/h4-5,8,12,22-23H,1-3,6-7,9-11,13-14,16-20,36H2	OAUJLQRXRHIUAR-UHFFFAOYSA-N	436879	US20260022132, Compound 563a	GTPase KRas [G12V]	Homo sapiens			 7.10						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436879	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436879&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493714	439658508							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212109	N#Cc1c(N)ccc2c1[C@]1(CCC2)Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc(N3CCOC[C@@H](n4ccc(F)n4)C3)c2CO1	InChI=1S/C33H38F2N8O3/c34-22-13-32(7-2-9-42(32)16-22)20-45-31-38-27-14-33(8-1-3-21-4-5-26(37)24(15-36)29(21)33)46-19-25(27)30(39-31)41-11-12-44-18-23(17-41)43-10-6-28(35)40-43/h4-6,10,22-23H,1-3,7-9,11-14,16-20,37H2	WDWKIWYHHXVGAW-UHFFFAOYSA-N	436880	US20260022132, Compound 564a	GTPase KRas [G12V]	Homo sapiens			 0.550						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436880	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436880&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493713	439658509							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212110	N#Cc1c(N)ccc2c1[C@]1(CCC2)Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc(N3CCOC[C@@H](n4ccc(F)n4)C3)c2CO1	InChI=1S/C33H38F2N8O3/c34-22-13-32(7-2-9-42(32)16-22)20-45-31-38-27-14-33(8-1-3-21-4-5-26(37)24(15-36)29(21)33)46-19-25(27)30(39-31)41-11-12-44-18-23(17-41)43-10-6-28(35)40-43/h4-6,10,22-23H,1-3,7-9,11-14,16-20,37H2	WDWKIWYHHXVGAW-UHFFFAOYSA-N	436880	US20260022132, Compound 564a	GTPase KRas [G12V]	Homo sapiens			 6.90						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436880	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436880&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493713	439658509							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212111	N#Cc1c(N)ccc2c1[C@]1(CCC2)Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc(N3CCOC[C@@H](n4nccc4F)C3)c2CO1	InChI=1S/C33H38F2N8O3/c34-22-13-32(7-2-10-42(32)16-22)20-45-31-39-27-14-33(8-1-3-21-4-5-26(37)24(15-36)29(21)33)46-19-25(27)30(40-31)41-11-12-44-18-23(17-41)43-28(35)6-9-38-43/h4-6,9,22-23H,1-3,7-8,10-14,16-20,37H2	MZQWHODBEWGYFM-UHFFFAOYSA-N	436881	US20260022132, Compound 565a	GTPase KRas [G12V]	Homo sapiens			 0.940						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436881	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436881&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493738	439658510							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212112	N#Cc1c(N)ccc2c1[C@]1(CCC2)Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc(N3CCOC[C@@H](n4nccc4F)C3)c2CO1	InChI=1S/C33H38F2N8O3/c34-22-13-32(7-2-10-42(32)16-22)20-45-31-39-27-14-33(8-1-3-21-4-5-26(37)24(15-36)29(21)33)46-19-25(27)30(40-31)41-11-12-44-18-23(17-41)43-28(35)6-9-38-43/h4-6,9,22-23H,1-3,7-8,10-14,16-20,37H2	MZQWHODBEWGYFM-UHFFFAOYSA-N	436881	US20260022132, Compound 565a	GTPase KRas [G12V]	Homo sapiens			 9.30						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436881	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436881&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493738	439658510							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212113	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC[C@H]4C#N)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C30H34FN7O2/c1-18-5-8-30(26-21(18)3-4-24(34)22(26)14-33)12-25-23(16-40-30)27(38-10-6-20(38)13-32)36-28(35-25)39-17-29-7-2-9-37(29)15-19(31)11-29/h3-4,18-20H,2,5-12,15-17,34H2,1H3	BCOPBZIACDBXSR-UHFFFAOYSA-N	436882	US20260022132, Compound 566a	GTPase KRas [G12V]	Homo sapiens			 0.220						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436882	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436882&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134494045	439658511							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212114	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC[C@H]4C#N)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C30H34FN7O2/c1-18-5-8-30(26-21(18)3-4-24(34)22(26)14-33)12-25-23(16-40-30)27(38-10-6-20(38)13-32)36-28(35-25)39-17-29-7-2-9-37(29)15-19(31)11-29/h3-4,18-20H,2,5-12,15-17,34H2,1H3	BCOPBZIACDBXSR-UHFFFAOYSA-N	436882	US20260022132, Compound 566a	GTPase KRas [G12V]	Homo sapiens			 3.10						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436882	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436882&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134494045	439658511							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212115	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC[C@@H]4C#N)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C30H34FN7O2/c1-18-5-8-30(26-21(18)3-4-24(34)22(26)14-33)12-25-23(16-40-30)27(38-10-6-20(38)13-32)36-28(35-25)39-17-29-7-2-9-37(29)15-19(31)11-29/h3-4,18-20H,2,5-12,15-17,34H2,1H3	BCOPBZIACDBXSR-UHFFFAOYSA-N	436883	US20260022132, Compound 566b	GTPase KRas [G12V]	Homo sapiens			 0.680						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436883	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436883&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493726	439658512							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212116	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC[C@@H]4C#N)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C30H34FN7O2/c1-18-5-8-30(26-21(18)3-4-24(34)22(26)14-33)12-25-23(16-40-30)27(38-10-6-20(38)13-32)36-28(35-25)39-17-29-7-2-9-37(29)15-19(31)11-29/h3-4,18-20H,2,5-12,15-17,34H2,1H3	BCOPBZIACDBXSR-UHFFFAOYSA-N	436883	US20260022132, Compound 566b	GTPase KRas [G12V]	Homo sapiens			 11.0						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436883	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436883&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493726	439658512							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212117	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC[C@@H]4C(N)=O)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C30H36FN7O3/c1-17-5-8-30(25-19(17)3-4-22(33)20(25)13-32)12-23-21(15-41-30)27(38-10-6-24(38)26(34)39)36-28(35-23)40-16-29-7-2-9-37(29)14-18(31)11-29/h3-4,17-18,24H,2,5-12,14-16,33H2,1H3,(H2,34,39)	KSXRNVAIRXXDMN-UHFFFAOYSA-N	436884	US20260022132, Compound 567a	GTPase KRas [G12V]	Homo sapiens			 0.660						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436884	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436884&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493773	439658513							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212118	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC[C@@H]4C(N)=O)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C30H36FN7O3/c1-17-5-8-30(25-19(17)3-4-22(33)20(25)13-32)12-23-21(15-41-30)27(38-10-6-24(38)26(34)39)36-28(35-23)40-16-29-7-2-9-37(29)14-18(31)11-29/h3-4,17-18,24H,2,5-12,14-16,33H2,1H3,(H2,34,39)	KSXRNVAIRXXDMN-UHFFFAOYSA-N	436884	US20260022132, Compound 567a	GTPase KRas [G12V]	Homo sapiens			 6.60						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436884	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436884&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493773	439658513							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212119	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC[C@H]4C(N)=O)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C30H36FN7O3/c1-17-5-8-30(25-19(17)3-4-22(33)20(25)13-32)12-23-21(15-41-30)27(38-10-6-24(38)26(34)39)36-28(35-23)40-16-29-7-2-9-37(29)14-18(31)11-29/h3-4,17-18,24H,2,5-12,14-16,33H2,1H3,(H2,34,39)	KSXRNVAIRXXDMN-UHFFFAOYSA-N	436885	US20260022132, Compound 567b	GTPase KRas [G12V]	Homo sapiens			 0.360						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436885	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436885&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493859	439658514							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212120	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC[C@H]4C(N)=O)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C30H36FN7O3/c1-17-5-8-30(25-19(17)3-4-22(33)20(25)13-32)12-23-21(15-41-30)27(38-10-6-24(38)26(34)39)36-28(35-23)40-16-29-7-2-9-37(29)14-18(31)11-29/h3-4,17-18,24H,2,5-12,14-16,33H2,1H3,(H2,34,39)	KSXRNVAIRXXDMN-UHFFFAOYSA-N	436885	US20260022132, Compound 567b	GTPase KRas [G12V]	Homo sapiens			 4.70						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436885	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436885&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493859	439658514							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212121	CNC(=O)[C@H]1CCN1c1nc(OC[C@@]23CCCN2C[C@H](F)C3)nc2c1CO[C@@]1(CC[C@H](C)c3ccc(N)c(C#N)c31)C2	InChI=1S/C31H38FN7O3/c1-18-6-9-31(26-20(18)4-5-23(34)21(26)14-33)13-24-22(16-42-31)27(39-11-7-25(39)28(40)35-2)37-29(36-24)41-17-30-8-3-10-38(30)15-19(32)12-30/h4-5,18-19,25H,3,6-13,15-17,34H2,1-2H3,(H,35,40)	IYUWQSXZDCYNOL-UHFFFAOYSA-N	436886	US20260022132, Compound 568a	GTPase KRas [G12V]	Homo sapiens			 16.0						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436886	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436886&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134494042	439658515							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212122	CNC(=O)[C@H]1CCN1c1nc(OC[C@@]23CCCN2C[C@H](F)C3)nc2c1CO[C@@]1(CC[C@H](C)c3ccc(N)c(C#N)c31)C2	InChI=1S/C31H38FN7O3/c1-18-6-9-31(26-20(18)4-5-23(34)21(26)14-33)13-24-22(16-42-31)27(39-11-7-25(39)28(40)35-2)37-29(36-24)41-17-30-8-3-10-38(30)15-19(32)12-30/h4-5,18-19,25H,3,6-13,15-17,34H2,1-2H3,(H,35,40)	IYUWQSXZDCYNOL-UHFFFAOYSA-N	436886	US20260022132, Compound 568a	GTPase KRas [G12V]	Homo sapiens			 140						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436886	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436886&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134494042	439658515							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212123	CNC(=O)[C@@H]1CCN1c1nc(OC[C@@]23CCCN2C[C@H](F)C3)nc2c1CO[C@@]1(CC[C@H](C)c3ccc(N)c(C#N)c31)C2	InChI=1S/C31H38FN7O3/c1-18-6-9-31(26-20(18)4-5-23(34)21(26)14-33)13-24-22(16-42-31)27(39-11-7-25(39)28(40)35-2)37-29(36-24)41-17-30-8-3-10-38(30)15-19(32)12-30/h4-5,18-19,25H,3,6-13,15-17,34H2,1-2H3,(H,35,40)	IYUWQSXZDCYNOL-UHFFFAOYSA-N	436887	US20260022132, Compound 568b	GTPase KRas [G12V]	Homo sapiens			 1.000						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436887	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436887&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493896	439658516							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212124	CNC(=O)[C@@H]1CCN1c1nc(OC[C@@]23CCCN2C[C@H](F)C3)nc2c1CO[C@@]1(CC[C@H](C)c3ccc(N)c(C#N)c31)C2	InChI=1S/C31H38FN7O3/c1-18-6-9-31(26-20(18)4-5-23(34)21(26)14-33)13-24-22(16-42-31)27(39-11-7-25(39)28(40)35-2)37-29(36-24)41-17-30-8-3-10-38(30)15-19(32)12-30/h4-5,18-19,25H,3,6-13,15-17,34H2,1-2H3,(H,35,40)	IYUWQSXZDCYNOL-UHFFFAOYSA-N	436887	US20260022132, Compound 568b	GTPase KRas [G12V]	Homo sapiens			 14.0						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436887	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436887&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493896	439658516							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212125	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC(C)(C#N)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C31H36FN7O2/c1-19-6-8-31(26-21(19)4-5-24(35)22(26)12-33)11-25-23(14-41-31)27(38-16-29(2,15-34)17-38)37-28(36-25)40-18-30-7-3-9-39(30)13-20(32)10-30/h4-5,19-20H,3,6-11,13-14,16-18,35H2,1-2H3	XYVNGIYERJPRIE-UHFFFAOYSA-N	436888	US20260022132, Compound 569a	GTPase KRas [G12V]	Homo sapiens			 1.60						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436888	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436888&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134494036	439658517							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212126	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC(C)(C#N)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C31H36FN7O2/c1-19-6-8-31(26-21(19)4-5-24(35)22(26)12-33)11-25-23(14-41-31)27(38-16-29(2,15-34)17-38)37-28(36-25)40-18-30-7-3-9-39(30)13-20(32)10-30/h4-5,19-20H,3,6-11,13-14,16-18,35H2,1-2H3	XYVNGIYERJPRIE-UHFFFAOYSA-N	436888	US20260022132, Compound 569a	GTPase KRas [G12V]	Homo sapiens			 18.0						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436888	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436888&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134494036	439658517							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212127	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC5(CCOC5)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H39FN6O3/c1-20-5-7-32(27-22(20)3-4-25(35)23(27)13-34)12-26-24(15-42-32)28(38-16-30(17-38)8-10-40-18-30)37-29(36-26)41-19-31-6-2-9-39(31)14-21(33)11-31/h3-4,20-21H,2,5-12,14-19,35H2,1H3	LFCHWLLLMVCDQA-UHFFFAOYSA-N	436889	US20260022132, Compound 570a	GTPase KRas [G12V]	Homo sapiens			 39.0						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436889	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436889&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134494052	439658518							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212128	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC5(CCOC5)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H39FN6O3/c1-20-5-7-32(27-22(20)3-4-25(35)23(27)13-34)12-26-24(15-42-32)28(38-16-30(17-38)8-10-40-18-30)37-29(36-26)41-19-31-6-2-9-39(31)14-21(33)11-31/h3-4,20-21H,2,5-12,14-19,35H2,1H3	LFCHWLLLMVCDQA-UHFFFAOYSA-N	436889	US20260022132, Compound 570a	GTPase KRas [G12V]	Homo sapiens			 280						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436889	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436889&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134494052	439658518							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212129	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC5(CCCO5)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H39FN6O3/c1-20-6-9-32(27-22(20)4-5-25(35)23(27)14-34)13-26-24(16-42-32)28(38-17-31(18-38)8-3-11-41-31)37-29(36-26)40-19-30-7-2-10-39(30)15-21(33)12-30/h4-5,20-21H,2-3,6-13,15-19,35H2,1H3	USQIDDUNOFWYNW-UHFFFAOYSA-N	436890	US20260022132, Compound 571a	GTPase KRas [G12V]	Homo sapiens			 15.0						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436890	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436890&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493697	439658519							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212130	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC5(CCCO5)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H39FN6O3/c1-20-6-9-32(27-22(20)4-5-25(35)23(27)14-34)13-26-24(16-42-32)28(38-17-31(18-38)8-3-11-41-31)37-29(36-26)40-19-30-7-2-10-39(30)15-21(33)12-30/h4-5,20-21H,2-3,6-13,15-19,35H2,1H3	USQIDDUNOFWYNW-UHFFFAOYSA-N	436890	US20260022132, Compound 571a	GTPase KRas [G12V]	Homo sapiens			 110						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436890	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436890&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493697	439658519							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212131	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC5(CC5C#N)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H36FN7O2/c1-19-5-7-32(27-22(19)3-4-25(36)23(27)13-35)11-26-24(15-42-32)28(39-16-30(17-39)9-20(30)12-34)38-29(37-26)41-18-31-6-2-8-40(31)14-21(33)10-31/h3-4,19-21H,2,5-11,14-18,36H2,1H3	VKMDQFXCVQSYRD-UHFFFAOYSA-N	436891	US20260022132, Compound 572a	GTPase KRas [G12V]	Homo sapiens			 38.0						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436891	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436891&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134494031	439658520							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212132	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC5(CC5C#N)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H36FN7O2/c1-19-5-7-32(27-22(19)3-4-25(36)23(27)13-35)11-26-24(15-42-32)28(39-16-30(17-39)9-20(30)12-34)38-29(37-26)41-18-31-6-2-8-40(31)14-21(33)10-31/h3-4,19-21H,2,5-11,14-18,36H2,1H3	VKMDQFXCVQSYRD-UHFFFAOYSA-N	436891	US20260022132, Compound 572a	GTPase KRas [G12V]	Homo sapiens			 250						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436891	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436891&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134494031	439658520							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212133	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4C[C@H]5COC[C@H]54)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C31H37FN6O3/c1-18-5-7-31(27-21(18)3-4-24(34)22(27)11-33)10-25-23(15-41-31)28(38-12-19-14-39-16-26(19)38)36-29(35-25)40-17-30-6-2-8-37(30)13-20(32)9-30/h3-4,18-20,26H,2,5-10,12-17,34H2,1H3	FFFIGCHXHTUULQ-UHFFFAOYSA-N	436892	US20260022132, Compound 573a	GTPase KRas [G12V]	Homo sapiens			 1.30						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436892	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436892&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134494054	439658521							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212134	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4C[C@H]5COC[C@H]54)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C31H37FN6O3/c1-18-5-7-31(27-21(18)3-4-24(34)22(27)11-33)10-25-23(15-41-31)28(38-12-19-14-39-16-26(19)38)36-29(35-25)40-17-30-6-2-8-37(30)13-20(32)9-30/h3-4,18-20,26H,2,5-10,12-17,34H2,1H3	FFFIGCHXHTUULQ-UHFFFAOYSA-N	436892	US20260022132, Compound 573a	GTPase KRas [G12V]	Homo sapiens			 13.0						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436892	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436892&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134494054	439658521							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212135	CNc1ccc2c(c1C#N)C1(CCC2)Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc(N3CCCn4nc(C(=O)N(C)C)c(Cl)c4C3)c2CO1	InChI=1S/C36H43ClFN9O3/c1-40-26-9-8-22-7-4-11-36(29(22)24(26)17-39)16-27-25(20-50-36)32(42-34(41-27)49-21-35-10-5-13-46(35)18-23(38)15-35)45-12-6-14-47-28(19-45)30(37)31(43-47)33(48)44(2)3/h8-9,23,40H,4-7,10-16,18-21H2,1-3H3	NYKXXFAXXVEEFV-UHFFFAOYSA-N	436893	US20260022132, Compound 574a	GTPase KRas [G12V]	Homo sapiens			 25.0						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436893	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436893&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493719	439658522							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212136	CNc1ccc2c(c1C#N)C1(CCC2)Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc(N3CCCn4nc(C(=O)N(C)C)c(Cl)c4C3)c2CO1	InChI=1S/C36H43ClFN9O3/c1-40-26-9-8-22-7-4-11-36(29(22)24(26)17-39)16-27-25(20-50-36)32(42-34(41-27)49-21-35-10-5-13-46(35)18-23(38)15-35)45-12-6-14-47-28(19-45)30(37)31(43-47)33(48)44(2)3/h8-9,23,40H,4-7,10-16,18-21H2,1-3H3	NYKXXFAXXVEEFV-UHFFFAOYSA-N	436893	US20260022132, Compound 574a	GTPase KRas [G12V]	Homo sapiens			 140						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436893	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436893&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493719	439658522							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212137	CNc1ccc2c(c1C#N)[C@]1(CCC2)Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc(N3CCCn4nc(C(=O)N(C)C)c(Cl)c4C3)c2CO1	InChI=1S/C36H43ClFN9O3/c1-40-26-9-8-22-7-4-11-36(29(22)24(26)17-39)16-27-25(20-50-36)32(42-34(41-27)49-21-35-10-5-13-46(35)18-23(38)15-35)45-12-6-14-47-28(19-45)30(37)31(43-47)33(48)44(2)3/h8-9,23,40H,4-7,10-16,18-21H2,1-3H3	NYKXXFAXXVEEFV-UHFFFAOYSA-N	436894	US20260022132, Compound 574b	GTPase KRas [G12V]	Homo sapiens			 11.0						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436894	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436894&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493717	439658523							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212138	CNc1ccc2c(c1C#N)[C@]1(CCC2)Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc(N3CCCn4nc(C(=O)N(C)C)c(Cl)c4C3)c2CO1	InChI=1S/C36H43ClFN9O3/c1-40-26-9-8-22-7-4-11-36(29(22)24(26)17-39)16-27-25(20-50-36)32(42-34(41-27)49-21-35-10-5-13-46(35)18-23(38)15-35)45-12-6-14-47-28(19-45)30(37)31(43-47)33(48)44(2)3/h8-9,23,40H,4-7,10-16,18-21H2,1-3H3	NYKXXFAXXVEEFV-UHFFFAOYSA-N	436894	US20260022132, Compound 574b	GTPase KRas [G12V]	Homo sapiens			 65.0						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436894	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436894&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493717	439658523							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212139	CNc1ccc2c(c1C#N)[C@@]1(CCC2)Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc(N3CCCn4nc(C(=O)N(C)C)c(Cl)c4C3)c2CO1	InChI=1S/C36H43ClFN9O3/c1-40-26-9-8-22-7-4-11-36(29(22)24(26)17-39)16-27-25(20-50-36)32(42-34(41-27)49-21-35-10-5-13-46(35)18-23(38)15-35)45-12-6-14-47-28(19-45)30(37)31(43-47)33(48)44(2)3/h8-9,23,40H,4-7,10-16,18-21H2,1-3H3	NYKXXFAXXVEEFV-UHFFFAOYSA-N	436895	US20260022132, Compound 574c	GTPase KRas [G12V]	Homo sapiens			>5000						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436895	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436895&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493729	439658524							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212140	CNc1ccc2c(c1C#N)[C@@]1(CCC2)Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc(N3CCCn4nc(C(=O)N(C)C)c(Cl)c4C3)c2CO1	InChI=1S/C36H43ClFN9O3/c1-40-26-9-8-22-7-4-11-36(29(22)24(26)17-39)16-27-25(20-50-36)32(42-34(41-27)49-21-35-10-5-13-46(35)18-23(38)15-35)45-12-6-14-47-28(19-45)30(37)31(43-47)33(48)44(2)3/h8-9,23,40H,4-7,10-16,18-21H2,1-3H3	NYKXXFAXXVEEFV-UHFFFAOYSA-N	436895	US20260022132, Compound 574c	GTPase KRas [G12V]	Homo sapiens			>5000						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436895	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436895&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493729	439658524							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212141	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC[C@@H]4C(=O)N(C)C)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H40FN7O3/c1-19-7-10-32(27-21(19)5-6-24(35)22(27)15-34)14-25-23(17-43-32)28(40-12-8-26(40)29(41)38(2)3)37-30(36-25)42-18-31-9-4-11-39(31)16-20(33)13-31/h5-6,19-20,26H,4,7-14,16-18,35H2,1-3H3	KIGOPEGIBJPSKT-UHFFFAOYSA-N	436896	US20260022132, Compound 575a	GTPase KRas [G12V]	Homo sapiens			 33.0						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436896	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436896&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493891	439658525							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212142	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC[C@H]4C(=O)N(C)C)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H40FN7O3/c1-19-7-10-32(27-21(19)5-6-24(35)22(27)15-34)14-25-23(17-43-32)28(40-12-8-26(40)29(41)38(2)3)37-30(36-25)42-18-31-9-4-11-39(31)16-20(33)13-31/h5-6,19-20,26H,4,7-14,16-18,35H2,1-3H3	KIGOPEGIBJPSKT-UHFFFAOYSA-N	436897	US20260022132, Compound 575b	GTPase KRas [G12V]	Homo sapiens			 34.0						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436897	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436897&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493728	439658526							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212143	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC[C@@H]4CO)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C30H37FN6O3/c1-18-5-8-30(26-21(18)3-4-24(33)22(26)13-32)12-25-23(16-40-30)27(37-10-6-20(37)15-38)35-28(34-25)39-17-29-7-2-9-36(29)14-19(31)11-29/h3-4,18-20,38H,2,5-12,14-17,33H2,1H3	RDJUPMCPGQTDON-UHFFFAOYSA-N	436898	(1S,4S)-7-Amino-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-4'-((R)-2-(hydroxymethyl)azetidin-1-yl)-4-methyl-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidine]-8-carbonitrile ::US20260022132, Compound 576a	GTPase KRas [G12V]	Homo sapiens			 0.037						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436898	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436898&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493790	439658527							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212144	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC[C@@H]4CO)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C30H37FN6O3/c1-18-5-8-30(26-21(18)3-4-24(33)22(26)13-32)12-25-23(16-40-30)27(37-10-6-20(37)15-38)35-28(34-25)39-17-29-7-2-9-36(29)14-19(31)11-29/h3-4,18-20,38H,2,5-12,14-17,33H2,1H3	RDJUPMCPGQTDON-UHFFFAOYSA-N	436898	(1S,4S)-7-Amino-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-4'-((R)-2-(hydroxymethyl)azetidin-1-yl)-4-methyl-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidine]-8-carbonitrile ::US20260022132, Compound 576a	GTPase KRas [G12V]	Homo sapiens			 0.190						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436898	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436898&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493790	439658527							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212145	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC[C@H]4CO)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C30H37FN6O3/c1-18-5-8-30(26-21(18)3-4-24(33)22(26)13-32)12-25-23(16-40-30)27(37-10-6-20(37)15-38)35-28(34-25)39-17-29-7-2-9-36(29)14-19(31)11-29/h3-4,18-20,38H,2,5-12,14-17,33H2,1H3	RDJUPMCPGQTDON-UHFFFAOYSA-N	436899	US20260022132, Compound 576b	GTPase KRas [G12V]	Homo sapiens			 0.290						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436899	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436899&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493593	439658528							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212146	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC[C@H]4CO)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C30H37FN6O3/c1-18-5-8-30(26-21(18)3-4-24(33)22(26)13-32)12-25-23(16-40-30)27(37-10-6-20(37)15-38)35-28(34-25)39-17-29-7-2-9-36(29)14-19(31)11-29/h3-4,18-20,38H,2,5-12,14-17,33H2,1H3	RDJUPMCPGQTDON-UHFFFAOYSA-N	436899	US20260022132, Compound 576b	GTPase KRas [G12V]	Homo sapiens			 3.60						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436899	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436899&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493593	439658528							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212147	C[C@H]1CC[C@@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC[C@@H]4CO)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C30H37FN6O3/c1-18-5-8-30(26-21(18)3-4-24(33)22(26)13-32)12-25-23(16-40-30)27(37-10-6-20(37)15-38)35-28(34-25)39-17-29-7-2-9-36(29)14-19(31)11-29/h3-4,18-20,38H,2,5-12,14-17,33H2,1H3	RDJUPMCPGQTDON-UHFFFAOYSA-N	436900	US20260022132, Compound 576c	GTPase KRas [G12V]	Homo sapiens			>500						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436900	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436900&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493799	439658529							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212148	C[C@H]1CC[C@@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC[C@H]4CO)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C30H37FN6O3/c1-18-5-8-30(26-21(18)3-4-24(33)22(26)13-32)12-25-23(16-40-30)27(37-10-6-20(37)15-38)35-28(34-25)39-17-29-7-2-9-36(29)14-19(31)11-29/h3-4,18-20,38H,2,5-12,14-17,33H2,1H3	RDJUPMCPGQTDON-UHFFFAOYSA-N	436901	US20260022132, Compound 576d	GTPase KRas [G12V]	Homo sapiens			>500						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436901	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436901&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493609	439658530							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212149	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC5(CC(C#N)C5)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C33H38FN7O2/c1-20-5-7-33(28-23(20)3-4-26(37)24(28)14-36)12-27-25(16-43-33)29(40-17-31(18-40)9-21(10-31)13-35)39-30(38-27)42-19-32-6-2-8-41(32)15-22(34)11-32/h3-4,20-22H,2,5-12,15-19,37H2,1H3	JMXPDWAHMFLSEV-UHFFFAOYSA-N	436902	US20260022132, Compound 577a	GTPase KRas [G12V]	Homo sapiens			 79.0						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436902	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436902&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493737	439658531							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212150	COC[C@H]1CCN1c1nc(OC[C@@]23CCCN2C[C@H](F)C3)nc2c1CO[C@@]1(CC[C@H](C)c3ccc(N)c(C#N)c31)C2	InChI=1S/C31H39FN6O3/c1-19-6-9-31(27-22(19)4-5-25(34)23(27)14-33)13-26-24(17-41-31)28(38-11-7-21(38)16-39-2)36-29(35-26)40-18-30-8-3-10-37(30)15-20(32)12-30/h4-5,19-21H,3,6-13,15-18,34H2,1-2H3	MSSFDNKNEQCXFM-UHFFFAOYSA-N	436903	(1S,4S)-7-Amino-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-4'-((R)-2-(methoxymethyl)azetidin-1-yl)-4-methyl-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidine]-8-carbonitrile ::US20260022132, Compound 578a	GTPase KRas [G12V]	Homo sapiens			 2.00						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436903	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436903&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493814	439658532							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212151	COC[C@H]1CCN1c1nc(OC[C@@]23CCCN2C[C@H](F)C3)nc2c1CO[C@@]1(CC[C@H](C)c3ccc(N)c(C#N)c31)C2	InChI=1S/C31H39FN6O3/c1-19-6-9-31(27-22(19)4-5-25(34)23(27)14-33)13-26-24(17-41-31)28(38-11-7-21(38)16-39-2)36-29(35-26)40-18-30-8-3-10-37(30)15-20(32)12-30/h4-5,19-21H,3,6-13,15-18,34H2,1-2H3	MSSFDNKNEQCXFM-UHFFFAOYSA-N	436903	(1S,4S)-7-Amino-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-4'-((R)-2-(methoxymethyl)azetidin-1-yl)-4-methyl-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidine]-8-carbonitrile ::US20260022132, Compound 578a	GTPase KRas [G12V]	Homo sapiens			 26.0						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436903	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436903&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493814	439658532							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212152	COC[C@@H]1CCN1c1nc(OC[C@@]23CCCN2C[C@H](F)C3)nc2c1CO[C@@]1(CC[C@H](C)c3ccc(N)c(C#N)c31)C2	InChI=1S/C31H39FN6O3/c1-19-6-9-31(27-22(19)4-5-25(34)23(27)14-33)13-26-24(17-41-31)28(38-11-7-21(38)16-39-2)36-29(35-26)40-18-30-8-3-10-37(30)15-20(32)12-30/h4-5,19-21H,3,6-13,15-18,34H2,1-2H3	MSSFDNKNEQCXFM-UHFFFAOYSA-N	436904	US20260022132, Compound 578b	GTPase KRas [G12V]	Homo sapiens			 0.200						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436904	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436904&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493817	439658533							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212153	COC[C@@H]1CCN1c1nc(OC[C@@]23CCCN2C[C@H](F)C3)nc2c1CO[C@@]1(CC[C@H](C)c3ccc(N)c(C#N)c31)C2	InChI=1S/C31H39FN6O3/c1-19-6-9-31(27-22(19)4-5-25(34)23(27)14-33)13-26-24(17-41-31)28(38-11-7-21(38)16-39-2)36-29(35-26)40-18-30-8-3-10-37(30)15-20(32)12-30/h4-5,19-21H,3,6-13,15-18,34H2,1-2H3	MSSFDNKNEQCXFM-UHFFFAOYSA-N	436904	US20260022132, Compound 578b	GTPase KRas [G12V]	Homo sapiens			 3.40						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436904	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436904&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493817	439658533							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212154	CC(C)(O)[C@H]1CCN1c1nc(OC[C@@]23CCCN2C[C@H](F)C3)nc2c1CO[C@@]1(CCCc3ccc(N)c(C#N)c31)C2	InChI=1S/C31H39FN6O3/c1-29(2,39)25-8-12-38(25)27-22-17-41-31(10-3-5-19-6-7-23(34)21(15-33)26(19)31)14-24(22)35-28(36-27)40-18-30-9-4-11-37(30)16-20(32)13-30/h6-7,20,25,39H,3-5,8-14,16-18,34H2,1-2H3	OIBJFGRCUMXUAX-UHFFFAOYSA-N	436905	US20260022132, Compound 579a	GTPase KRas [G12V]	Homo sapiens			 8.20						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436905	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436905&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493785	439658534							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212155	CC(C)(O)[C@H]1CCN1c1nc(OC[C@@]23CCCN2C[C@H](F)C3)nc2c1CO[C@@]1(CCCc3ccc(N)c(C#N)c31)C2	InChI=1S/C31H39FN6O3/c1-29(2,39)25-8-12-38(25)27-22-17-41-31(10-3-5-19-6-7-23(34)21(15-33)26(19)31)14-24(22)35-28(36-27)40-18-30-9-4-11-37(30)16-20(32)13-30/h6-7,20,25,39H,3-5,8-14,16-18,34H2,1-2H3	OIBJFGRCUMXUAX-UHFFFAOYSA-N	436905	US20260022132, Compound 579a	GTPase KRas [G12V]	Homo sapiens			 74.0						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436905	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436905&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493785	439658534							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212156	N#Cc1c(N)ccc2c1[C@]1(CCC2)Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc(N3CCC34CCOC4)c2CO1	InChI=1S/C31H37FN6O3/c32-21-13-30(6-2-10-37(30)16-21)19-40-28-35-25-14-31(7-1-3-20-4-5-24(34)22(15-33)26(20)31)41-17-23(25)27(36-28)38-11-8-29(38)9-12-39-18-29/h4-5,21H,1-3,6-14,16-19,34H2	GISWTTUEVHIJSY-UHFFFAOYSA-N	436906	US20260022132, Compound 580a	GTPase KRas [G12V]	Homo sapiens			 0.360						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436906	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436906&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493715	439658535							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212157	N#Cc1c(N)ccc2c1[C@]1(CCC2)Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc(N3CCC34CCOC4)c2CO1	InChI=1S/C31H37FN6O3/c32-21-13-30(6-2-10-37(30)16-21)19-40-28-35-25-14-31(7-1-3-20-4-5-24(34)22(15-33)26(20)31)41-17-23(25)27(36-28)38-11-8-29(38)9-12-39-18-29/h4-5,21H,1-3,6-14,16-19,34H2	GISWTTUEVHIJSY-UHFFFAOYSA-N	436906	US20260022132, Compound 580a	GTPase KRas [G12V]	Homo sapiens			 1.80						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436906	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436906&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493715	439658535							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212158	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCOC[C@@H](c5ncco5)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C34H40FN7O4/c1-21-5-7-34(29-24(21)3-4-27(37)25(29)15-36)14-28-26(19-46-34)30(41-10-12-43-18-22(16-41)31-38-8-11-44-31)40-32(39-28)45-20-33-6-2-9-42(33)17-23(35)13-33/h3-4,8,11,21-23H,2,5-7,9-10,12-14,16-20,37H2,1H3	DSTCBNCTDYCXIO-UHFFFAOYSA-N	436907	US20260022132, Compound 581a	GTPase KRas [G12V]	Homo sapiens			 0.110						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436907	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436907&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493831	439658536							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212159	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCOC[C@@H](c5ncco5)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C34H40FN7O4/c1-21-5-7-34(29-24(21)3-4-27(37)25(29)15-36)14-28-26(19-46-34)30(41-10-12-43-18-22(16-41)31-38-8-11-44-31)40-32(39-28)45-20-33-6-2-9-42(33)17-23(35)13-33/h3-4,8,11,21-23H,2,5-7,9-10,12-14,16-20,37H2,1H3	DSTCBNCTDYCXIO-UHFFFAOYSA-N	436907	US20260022132, Compound 581a	GTPase KRas [G12V]	Homo sapiens			 1.40						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436907	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436907&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493831	439658536							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212160	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC5(CC(C(N)=O)C5)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C33H40FN7O3/c1-19-5-7-33(27-22(19)3-4-25(36)23(27)13-35)12-26-24(15-44-33)29(40-16-31(17-40)9-20(10-31)28(37)42)39-30(38-26)43-18-32-6-2-8-41(32)14-21(34)11-32/h3-4,19-21H,2,5-12,14-18,36H2,1H3,(H2,37,42)	JBVWJBHKZZKJHM-UHFFFAOYSA-N	436908	US20260022132, Compound 582a	GTPase KRas [G12V]	Homo sapiens			 6.80						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436908	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436908&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493833	439658537							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212161	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC5(CC(C(N)=O)C5)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C33H40FN7O3/c1-19-5-7-33(27-22(19)3-4-25(36)23(27)13-35)12-26-24(15-44-33)29(40-16-31(17-40)9-20(10-31)28(37)42)39-30(38-26)43-18-32-6-2-8-41(32)14-21(34)11-32/h3-4,19-21H,2,5-12,14-18,36H2,1H3,(H2,37,42)	JBVWJBHKZZKJHM-UHFFFAOYSA-N	436908	US20260022132, Compound 582a	GTPase KRas [G12V]	Homo sapiens			 68.0						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436908	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436908&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493833	439658537							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212162	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCC45CCC5)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H39FN6O2/c1-20-6-10-32(27-22(20)4-5-25(35)23(27)16-34)15-26-24(18-41-32)28(39-13-11-30(39)7-2-8-30)37-29(36-26)40-19-31-9-3-12-38(31)17-21(33)14-31/h4-5,20-21H,2-3,6-15,17-19,35H2,1H3	XJRBJOPLPRLUHN-UHFFFAOYSA-N	436909	US20260022132, Compound 583a	GTPase KRas [G12V]	Homo sapiens			 0.068						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436909	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436909&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			155295429	439658538							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212163	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCC45CCC5)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H39FN6O2/c1-20-6-10-32(27-22(20)4-5-25(35)23(27)16-34)15-26-24(18-41-32)28(39-13-11-30(39)7-2-8-30)37-29(36-26)40-19-31-9-3-12-38(31)17-21(33)14-31/h4-5,20-21H,2-3,6-15,17-19,35H2,1H3	XJRBJOPLPRLUHN-UHFFFAOYSA-N	436909	US20260022132, Compound 583a	GTPase KRas [G12V]	Homo sapiens			 0.710						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436909	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436909&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			155295429	439658538							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212164	Cc1c(C(=O)N(C)C)nn2c1CN(c1nc(OC[C@@]34CCCN3CC(F)(F)C4)nc3c1CO[C@@]1(CC[C@H](C)c4ccc(N)c(C#N)c41)C3)CCC2	InChI=1S/C37H45F2N9O3/c1-22-9-11-36(30-24(22)7-8-27(41)25(30)16-40)15-28-26(18-51-36)32(43-34(42-28)50-21-35-10-5-13-47(35)20-37(38,39)19-35)46-12-6-14-48-29(17-46)23(2)31(44-48)33(49)45(3)4/h7-8,22H,5-6,9-15,17-21,41H2,1-4H3	VLNBTPXKAQJHJE-UHFFFAOYSA-N	436910	US20260022132, Compound 584a	GTPase KRas [G12V]	Homo sapiens			 0.088						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436910	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436910&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493708	439658539							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212165	Cc1c(C(=O)N(C)C)nn2c1CN(c1nc(OC[C@@]34CCCN3CC(F)(F)C4)nc3c1CO[C@@]1(CC[C@H](C)c4ccc(N)c(C#N)c41)C3)CCC2	InChI=1S/C37H45F2N9O3/c1-22-9-11-36(30-24(22)7-8-27(41)25(30)16-40)15-28-26(18-51-36)32(43-34(42-28)50-21-35-10-5-13-47(35)20-37(38,39)19-35)46-12-6-14-48-29(17-46)23(2)31(44-48)33(49)45(3)4/h7-8,22H,5-6,9-15,17-21,41H2,1-4H3	VLNBTPXKAQJHJE-UHFFFAOYSA-N	436910	US20260022132, Compound 584a	GTPase KRas [G12V]	Homo sapiens			 0.250						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436910	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436910&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493708	439658539							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212166	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC[C@@]45CCCOC5)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C33H41FN6O3/c1-21-6-9-33(28-23(21)4-5-26(36)24(28)16-35)15-27-25(18-43-33)29(40-12-10-31(40)8-3-13-41-19-31)38-30(37-27)42-20-32-7-2-11-39(32)17-22(34)14-32/h4-5,21-22H,2-3,6-15,17-20,36H2,1H3	SZFNANJMUTVUTH-UHFFFAOYSA-N	436911	(1S,4S)-7-amino-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-4-methyl-4'-((R)-6-oxa-1-azaspiro[3.5]nonan-1-yl)-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidine]-8-carbonitrile ::US20260022132, Compound 585a	GTPase KRas [G12V]	Homo sapiens			 0.029						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436911	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436911&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490032	439658540							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212167	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC[C@@]45CCCOC5)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C33H41FN6O3/c1-21-6-9-33(28-23(21)4-5-26(36)24(28)16-35)15-27-25(18-43-33)29(40-12-10-31(40)8-3-13-41-19-31)38-30(37-27)42-20-32-7-2-11-39(32)17-22(34)14-32/h4-5,21-22H,2-3,6-15,17-20,36H2,1H3	SZFNANJMUTVUTH-UHFFFAOYSA-N	436911	(1S,4S)-7-amino-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-4-methyl-4'-((R)-6-oxa-1-azaspiro[3.5]nonan-1-yl)-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidine]-8-carbonitrile ::US20260022132, Compound 585a	GTPase KRas [G12V]	Homo sapiens			 0.120						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436911	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436911&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490032	439658540							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212168	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC[C@]45CCCOC5)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C33H41FN6O3/c1-21-6-9-33(28-23(21)4-5-26(36)24(28)16-35)15-27-25(18-43-33)29(40-12-10-31(40)8-3-13-41-19-31)38-30(37-27)42-20-32-7-2-11-39(32)17-22(34)14-32/h4-5,21-22H,2-3,6-15,17-20,36H2,1H3	SZFNANJMUTVUTH-UHFFFAOYSA-N	436912	(1S,4S)-7-amino-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-4-methyl-4'-((S)-6-oxa-1-azaspiro[3.5]nonan-1-yl)-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidine]-8-carbonitrile ::US20260022132, Compound 585b	GTPase KRas [G12V]	Homo sapiens			 0.420						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436912	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436912&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490033	439658541							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212169	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC[C@]45CCCOC5)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C33H41FN6O3/c1-21-6-9-33(28-23(21)4-5-26(36)24(28)16-35)15-27-25(18-43-33)29(40-12-10-31(40)8-3-13-41-19-31)38-30(37-27)42-20-32-7-2-11-39(32)17-22(34)14-32/h4-5,21-22H,2-3,6-15,17-20,36H2,1H3	SZFNANJMUTVUTH-UHFFFAOYSA-N	436912	(1S,4S)-7-amino-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-4-methyl-4'-((S)-6-oxa-1-azaspiro[3.5]nonan-1-yl)-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidine]-8-carbonitrile ::US20260022132, Compound 585b	GTPase KRas [G12V]	Homo sapiens			 7.30						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436912	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436912&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490033	439658541							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212170	N#Cc1c(N)ccc2c1[C@]1(CCC2)Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc(N3CC[C@@H]3C(F)F)c2CO1	InChI=1S/C29H33F3N6O2/c30-18-11-28(7-2-9-37(28)14-18)16-39-27-35-22-12-29(8-1-3-17-4-5-21(34)19(13-33)24(17)29)40-15-20(22)26(36-27)38-10-6-23(38)25(31)32/h4-5,18,23,25H,1-3,6-12,14-16,34H2	KHJQGORKOCWUMZ-UHFFFAOYSA-N	436913	US20260022132, Compound 586a	GTPase KRas [G12V]	Homo sapiens			 1.50						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436913	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436913&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490034	439658542							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212171	N#Cc1c(N)ccc2c1[C@]1(CCC2)Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc(N3CC[C@@H]3C(F)F)c2CO1	InChI=1S/C29H33F3N6O2/c30-18-11-28(7-2-9-37(28)14-18)16-39-27-35-22-12-29(8-1-3-17-4-5-21(34)19(13-33)24(17)29)40-15-20(22)26(36-27)38-10-6-23(38)25(31)32/h4-5,18,23,25H,1-3,6-12,14-16,34H2	KHJQGORKOCWUMZ-UHFFFAOYSA-N	436913	US20260022132, Compound 586a	GTPase KRas [G12V]	Homo sapiens			 23.0						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436913	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436913&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490034	439658542							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212172	CN1CCC2(CCN2c2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc3c2CO[C@@]2(CCCc4ccc(N)c(C#N)c42)C3)C1	InChI=1S/C32H40FN7O2/c1-38-12-9-30(19-38)10-13-40(30)28-24-18-42-32(8-2-4-21-5-6-25(35)23(16-34)27(21)32)15-26(24)36-29(37-28)41-20-31-7-3-11-39(31)17-22(33)14-31/h5-6,22H,2-4,7-15,17-20,35H2,1H3	UBKMCASEGDXZIE-UHFFFAOYSA-N	436914	US20260022132, Compound 587a	GTPase KRas [G12V]	Homo sapiens			 24.0						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436914	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436914&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490037	439658543							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212173	CN1CCC2(CCN2c2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc3c2CO[C@@]2(CCCc4ccc(N)c(C#N)c42)C3)C1	InChI=1S/C32H40FN7O2/c1-38-12-9-30(19-38)10-13-40(30)28-24-18-42-32(8-2-4-21-5-6-25(35)23(16-34)27(21)32)15-26(24)36-29(37-28)41-20-31-7-3-11-39(31)17-22(33)14-31/h5-6,22H,2-4,7-15,17-20,35H2,1H3	UBKMCASEGDXZIE-UHFFFAOYSA-N	436914	US20260022132, Compound 587a	GTPase KRas [G12V]	Homo sapiens			 190						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436914	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436914&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490037	439658543							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212174	CN(C)C(=O)c1cc2n(n1)CCCN(c1nc(OC[C@@]34CCCN3CC(F)(F)C4)nc3c1CO[C@@]1(CCCc4ccc(N)c(C#N)c41)C3)C2	InChI=1S/C35H41F2N9O3/c1-43(2)31(47)27-14-23-17-44(11-5-13-46(23)42-27)30-25-18-49-34(10-3-6-22-7-8-26(39)24(16-38)29(22)34)15-28(25)40-32(41-30)48-21-33-9-4-12-45(33)20-35(36,37)19-33/h7-8,14H,3-6,9-13,15,17-21,39H2,1-2H3	MVSHBSDPVANNEM-UHFFFAOYSA-N	436915	US20260022132, Compound 588a	GTPase KRas [G12V]	Homo sapiens			 0.330						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436915	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436915&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490035	439658544							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212175	CN(C)C(=O)c1cc2n(n1)CCCN(c1nc(OC[C@@]34CCCN3CC(F)(F)C4)nc3c1CO[C@@]1(CCCc4ccc(N)c(C#N)c41)C3)C2	InChI=1S/C35H41F2N9O3/c1-43(2)31(47)27-14-23-17-44(11-5-13-46(23)42-27)30-25-18-49-34(10-3-6-22-7-8-26(39)24(16-38)29(22)34)15-28(25)40-32(41-30)48-21-33-9-4-12-45(33)20-35(36,37)19-33/h7-8,14H,3-6,9-13,15,17-21,39H2,1-2H3	MVSHBSDPVANNEM-UHFFFAOYSA-N	436915	US20260022132, Compound 588a	GTPase KRas [G12V]	Homo sapiens			 13.0						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436915	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436915&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490035	439658544							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212176	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCC45CCOCC5)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C33H41FN6O3/c1-21-5-7-33(28-23(21)3-4-26(36)24(28)17-35)16-27-25(19-43-33)29(40-12-8-31(40)9-13-41-14-10-31)38-30(37-27)42-20-32-6-2-11-39(32)18-22(34)15-32/h3-4,21-22H,2,5-16,18-20,36H2,1H3	JTAFLEZGDXBACY-UHFFFAOYSA-N	436916	(1S,4S)-7-Amino-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-4-methyl-4'-(7-oxa-1-azaspiro[3.5]nonan-1-yl)-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidine]-8-carbonitrile ::US20260022132, Compound 589a	GTPase KRas [G12V]	Homo sapiens			 0.410						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436916	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436916&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490036	439658545							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212177	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCC45CCOCC5)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C33H41FN6O3/c1-21-5-7-33(28-23(21)3-4-26(36)24(28)17-35)16-27-25(19-43-33)29(40-12-8-31(40)9-13-41-14-10-31)38-30(37-27)42-20-32-6-2-11-39(32)18-22(34)15-32/h3-4,21-22H,2,5-16,18-20,36H2,1H3	JTAFLEZGDXBACY-UHFFFAOYSA-N	436916	(1S,4S)-7-Amino-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-4-methyl-4'-(7-oxa-1-azaspiro[3.5]nonan-1-yl)-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidine]-8-carbonitrile ::US20260022132, Compound 589a	GTPase KRas [G12V]	Homo sapiens			 4.30						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436916	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436916&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490036	439658545							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212178	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4CC(F)(F)C5)nc(N4CCCn5nc(C(=O)N(C)C)c(F)c5C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C36H42F3N9O3/c1-21-8-10-35(28-22(21)6-7-25(41)23(28)15-40)14-26-24(17-51-35)31(43-33(42-26)50-20-34-9-4-12-47(34)19-36(38,39)18-34)46-11-5-13-48-27(16-46)29(37)30(44-48)32(49)45(2)3/h6-7,21H,4-5,8-14,16-20,41H2,1-3H3	DZOBLMMRJWKQMM-UHFFFAOYSA-N	436917	US20260022132, Compound 590a	GTPase KRas [G12V]	Homo sapiens			 0.043						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436917	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436917&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493893	439658546							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212179	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4CC(F)(F)C5)nc(N4CCCn5nc(C(=O)N(C)C)c(F)c5C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C36H42F3N9O3/c1-21-8-10-35(28-22(21)6-7-25(41)23(28)15-40)14-26-24(17-51-35)31(43-33(42-26)50-20-34-9-4-12-47(34)19-36(38,39)18-34)46-11-5-13-48-27(16-46)29(37)30(44-48)32(49)45(2)3/h6-7,21H,4-5,8-14,16-20,41H2,1-3H3	DZOBLMMRJWKQMM-UHFFFAOYSA-N	436917	US20260022132, Compound 590a	GTPase KRas [G12V]	Homo sapiens			 0.300						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436917	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436917&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493893	439658546							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212180	Cc1c(C(=O)N(C)C)nn2c1CN(c1nc(OC[C@@]34CCCN3CC(F)(F)C4)nc3c1CO[C@@]1(CCCc4ccc(N)c(C#N)c41)C3)CCC2	InChI=1S/C36H43F2N9O3/c1-22-28-17-45(12-6-14-47(28)43-30(22)32(48)44(2)3)31-25-18-50-35(11-4-7-23-8-9-26(40)24(16-39)29(23)35)15-27(25)41-33(42-31)49-21-34-10-5-13-46(34)20-36(37,38)19-34/h8-9H,4-7,10-15,17-21,40H2,1-3H3	AROFIEWVOMBLME-UHFFFAOYSA-N	436918	US20260022132, Compound 591a	GTPase KRas [G12V]	Homo sapiens			 0.120						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436918	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436918&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493781	439658547							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212181	Cc1c(C(=O)N(C)C)nn2c1CN(c1nc(OC[C@@]34CCCN3CC(F)(F)C4)nc3c1CO[C@@]1(CCCc4ccc(N)c(C#N)c41)C3)CCC2	InChI=1S/C36H43F2N9O3/c1-22-28-17-45(12-6-14-47(28)43-30(22)32(48)44(2)3)31-25-18-50-35(11-4-7-23-8-9-26(40)24(16-39)29(23)35)15-27(25)41-33(42-31)49-21-34-10-5-13-46(34)20-36(37,38)19-34/h8-9H,4-7,10-15,17-21,40H2,1-3H3	AROFIEWVOMBLME-UHFFFAOYSA-N	436918	US20260022132, Compound 591a	GTPase KRas [G12V]	Homo sapiens			 1.000						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436918	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436918&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493781	439658547							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212182	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCC4(CO)CO)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C31H39FN6O4/c1-19-5-7-31(26-21(19)3-4-24(34)22(26)13-33)12-25-23(15-42-31)27(38-10-8-30(38,16-39)17-40)36-28(35-25)41-18-29-6-2-9-37(29)14-20(32)11-29/h3-4,19-20,39-40H,2,5-12,14-18,34H2,1H3	XSNKISPQEXIIOD-UHFFFAOYSA-N	436919	(1S,4S)-7-Amino-4'-(2,2-bis(hydroxymethyl)azetidin-1-yl)-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-4-methyl-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidine]-8-carbonitrile ::US20260022132, Compound 592a	GTPase KRas [G12V]	Homo sapiens			 0.026						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436919	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436919&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493903	439658548							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212183	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCC4(CO)CO)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C31H39FN6O4/c1-19-5-7-31(26-21(19)3-4-24(34)22(26)13-33)12-25-23(15-42-31)27(38-10-8-30(38,16-39)17-40)36-28(35-25)41-18-29-6-2-9-37(29)14-20(32)11-29/h3-4,19-20,39-40H,2,5-12,14-18,34H2,1H3	XSNKISPQEXIIOD-UHFFFAOYSA-N	436919	(1S,4S)-7-Amino-4'-(2,2-bis(hydroxymethyl)azetidin-1-yl)-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-4-methyl-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidine]-8-carbonitrile ::US20260022132, Compound 592a	GTPase KRas [G12V]	Homo sapiens			 0.170						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436919	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436919&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493903	439658548							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212184	N#Cc1c(N)ccc2c1[C@]1(CCC2)Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc(N3CC4(CCC(=O)N4)C3)c2CO1	InChI=1S/C31H36FN7O3/c32-20-11-30(7-2-10-39(30)14-20)18-41-28-35-24-12-31(8-1-3-19-4-5-23(34)21(13-33)26(19)31)42-15-22(24)27(36-28)38-16-29(17-38)9-6-25(40)37-29/h4-5,20H,1-3,6-12,14-18,34H2,(H,37,40)	NSRVDXWKONSYMP-UHFFFAOYSA-N	436920	US20260022132, Compound 593a	GTPase KRas [G12V]	Homo sapiens			 97.0						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436920	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436920&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493822	439658549							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212185	N#Cc1c(N)ccc2c1[C@]1(CCC2)Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc(N3CC4(CCC(=O)N4)C3)c2CO1	InChI=1S/C31H36FN7O3/c32-20-11-30(7-2-10-39(30)14-20)18-41-28-35-24-12-31(8-1-3-19-4-5-23(34)21(13-33)26(19)31)42-15-22(24)27(36-28)38-16-29(17-38)9-6-25(40)37-29/h4-5,20H,1-3,6-12,14-18,34H2,(H,37,40)	NSRVDXWKONSYMP-UHFFFAOYSA-N	436920	US20260022132, Compound 593a	GTPase KRas [G12V]	Homo sapiens			 630						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436920	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436920&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493822	439658549							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212186	CN(C)C(=O)c1nn2c(c1F)CN(c1nc(OC[C@@]34CCCN3CC(F)(F)C4)nc3c1CO[C@@]1(CCCc4ccc(N)c(C#N)c41)C3)CCC2	InChI=1S/C35H40F3N9O3/c1-44(2)31(48)29-28(36)26-16-45(11-5-13-47(26)43-29)30-23-17-50-34(10-3-6-21-7-8-24(40)22(15-39)27(21)34)14-25(23)41-32(42-30)49-20-33-9-4-12-46(33)19-35(37,38)18-33/h7-8H,3-6,9-14,16-20,40H2,1-2H3	FYMHATAACKCDFX-UHFFFAOYSA-N	436921	US20260022132, Compound 594a	GTPase KRas [G12V]	Homo sapiens			 0.100						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436921	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436921&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493588	439658550							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212187	CN(C)C(=O)c1nn2c(c1F)CN(c1nc(OC[C@@]34CCCN3CC(F)(F)C4)nc3c1CO[C@@]1(CCCc4ccc(N)c(C#N)c41)C3)CCC2	InChI=1S/C35H40F3N9O3/c1-44(2)31(48)29-28(36)26-16-45(11-5-13-47(26)43-29)30-23-17-50-34(10-3-6-21-7-8-24(40)22(15-39)27(21)34)14-25(23)41-32(42-30)49-20-33-9-4-12-46(33)19-35(37,38)18-33/h7-8H,3-6,9-14,16-20,40H2,1-2H3	FYMHATAACKCDFX-UHFFFAOYSA-N	436921	US20260022132, Compound 594a	GTPase KRas [G12V]	Homo sapiens			 2.10						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436921	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436921&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493588	439658550							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212188	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCC4=O)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C29H33FN6O3/c1-17-5-8-29(25-19(17)3-4-22(32)20(25)13-31)12-23-21(15-39-29)26(36-10-6-24(36)37)34-27(33-23)38-16-28-7-2-9-35(28)14-18(30)11-28/h3-4,17-18H,2,5-12,14-16,32H2,1H3	FNZGKDYDOWSBAY-UHFFFAOYSA-N	436922	US20260022132, Compound 595a	GTPase KRas [G12V]	Homo sapiens			 0.390						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436922	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436922&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493617	439658551							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212189	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCC4=O)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C29H33FN6O3/c1-17-5-8-29(25-19(17)3-4-22(32)20(25)13-31)12-23-21(15-39-29)26(36-10-6-24(36)37)34-27(33-23)38-16-28-7-2-9-35(28)14-18(30)11-28/h3-4,17-18H,2,5-12,14-16,32H2,1H3	FNZGKDYDOWSBAY-UHFFFAOYSA-N	436922	US20260022132, Compound 595a	GTPase KRas [G12V]	Homo sapiens			 7.20						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436922	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436922&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493617	439658551							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212190	C[C@H]1CCC2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCC4=O)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C29H33FN6O3/c1-17-5-8-29(25-19(17)3-4-22(32)20(25)13-31)12-23-21(15-39-29)26(36-10-6-24(36)37)34-27(33-23)38-16-28-7-2-9-35(28)14-18(30)11-28/h3-4,17-18H,2,5-12,14-16,32H2,1H3	FNZGKDYDOWSBAY-UHFFFAOYSA-N	436923	US20260022132, Compound 595b	GTPase KRas [G12V]	Homo sapiens			 0.430						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436923	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436923&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493778	439658552							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212191	C[C@H]1CCC2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCC4=O)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C29H33FN6O3/c1-17-5-8-29(25-19(17)3-4-22(32)20(25)13-31)12-23-21(15-39-29)26(36-10-6-24(36)37)34-27(33-23)38-16-28-7-2-9-35(28)14-18(30)11-28/h3-4,17-18H,2,5-12,14-16,32H2,1H3	FNZGKDYDOWSBAY-UHFFFAOYSA-N	436923	US20260022132, Compound 595b	GTPase KRas [G12V]	Homo sapiens			 8.20						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436923	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436923&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493778	439658552							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212192	C[C@H]1CC[C@]2(Cc3nc(OCCCN4CCOCC4)nc(N4CCCn5nc(C(=O)N(C)C)c(Cl)c5C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C35H44ClN9O4/c1-22-8-9-35(29-23(22)6-7-26(38)24(29)19-37)18-27-25(21-49-35)32(40-34(39-27)48-15-5-10-43-13-16-47-17-14-43)44-11-4-12-45-28(20-44)30(36)31(41-45)33(46)42(2)3/h6-7,22H,4-5,8-18,20-21,38H2,1-3H3	KWJZINASTCWNQE-UHFFFAOYSA-N	436924	US20260022132, Compound 596a	GTPase KRas [G12V]	Homo sapiens			 1.000						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436924	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436924&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493612	439658553							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212193	C[C@H]1CC[C@]2(Cc3nc(OCCCN4CCOCC4)nc(N4CCCn5nc(C(=O)N(C)C)c(Cl)c5C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C35H44ClN9O4/c1-22-8-9-35(29-23(22)6-7-26(38)24(29)19-37)18-27-25(21-49-35)32(40-34(39-27)48-15-5-10-43-13-16-47-17-14-43)44-11-4-12-45-28(20-44)30(36)31(41-45)33(46)42(2)3/h6-7,22H,4-5,8-18,20-21,38H2,1-3H3	KWJZINASTCWNQE-UHFFFAOYSA-N	436924	US20260022132, Compound 596a	GTPase KRas [G12V]	Homo sapiens			 15.0						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436924	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436924&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493612	439658553							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212194	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC[C@]4(C)CO)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C31H39FN6O3/c1-19-6-8-31(26-21(19)4-5-24(34)22(26)14-33)13-25-23(16-41-31)27(38-11-9-29(38,2)17-39)36-28(35-25)40-18-30-7-3-10-37(30)15-20(32)12-30/h4-5,19-20,39H,3,6-13,15-18,34H2,1-2H3	HRTYKBHLPJAKIA-UHFFFAOYSA-N	436925	(1S,4S)-7-Amino-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-4'-((R)-2-(hydroxymethyl)-2-methylazetidin-1-yl)-4-methyl-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidine]-8-carbonitrile ::US20260022132, Compound 597a	GTPase KRas [G12V]	Homo sapiens			 0.017						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436925	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436925&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493801	439658554							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212195	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC[C@]4(C)CO)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C31H39FN6O3/c1-19-6-8-31(26-21(19)4-5-24(34)22(26)14-33)13-25-23(16-41-31)27(38-11-9-29(38,2)17-39)36-28(35-25)40-18-30-7-3-10-37(30)15-20(32)12-30/h4-5,19-20,39H,3,6-13,15-18,34H2,1-2H3	HRTYKBHLPJAKIA-UHFFFAOYSA-N	436925	(1S,4S)-7-Amino-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-4'-((R)-2-(hydroxymethyl)-2-methylazetidin-1-yl)-4-methyl-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidine]-8-carbonitrile ::US20260022132, Compound 597a	GTPase KRas [G12V]	Homo sapiens			 0.068						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436925	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436925&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493801	439658554							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212196	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC[C@@]4(C)CO)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C31H39FN6O3/c1-19-6-8-31(26-21(19)4-5-24(34)22(26)14-33)13-25-23(16-41-31)27(38-11-9-29(38,2)17-39)36-28(35-25)40-18-30-7-3-10-37(30)15-20(32)12-30/h4-5,19-20,39H,3,6-13,15-18,34H2,1-2H3	HRTYKBHLPJAKIA-UHFFFAOYSA-N	436926	US20260022132, Compound 597b	GTPase KRas [G12V]	Homo sapiens			 0.051						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436926	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436926&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490038	439658555							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212197	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC[C@@]4(C)CO)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C31H39FN6O3/c1-19-6-8-31(26-21(19)4-5-24(34)22(26)14-33)13-25-23(16-41-31)27(38-11-9-29(38,2)17-39)36-28(35-25)40-18-30-7-3-10-37(30)15-20(32)12-30/h4-5,19-20,39H,3,6-13,15-18,34H2,1-2H3	HRTYKBHLPJAKIA-UHFFFAOYSA-N	436926	US20260022132, Compound 597b	GTPase KRas [G12V]	Homo sapiens			 0.750						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436926	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436926&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490038	439658555							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212198	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCC45CCOC5)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H39FN6O3/c1-20-5-7-32(27-22(20)3-4-25(35)23(27)15-34)14-26-24(17-42-32)28(39-11-8-30(39)9-12-40-18-30)37-29(36-26)41-19-31-6-2-10-38(31)16-21(33)13-31/h3-4,20-21H,2,5-14,16-19,35H2,1H3	DGUONHWWQZQJLK-UHFFFAOYSA-N	436927	(1S,4S)-7-Amino-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-4-methyl-4'-(6-oxa-1-azaspiro[3.4]octan-1-yl)-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidine]-8-carbonitrile ::US20260022132, Compound 598a	GTPase KRas [G12V]	Homo sapiens			 0.087						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436927	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436927&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493753	439658556							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212199	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCC45CCOC5)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H39FN6O3/c1-20-5-7-32(27-22(20)3-4-25(35)23(27)15-34)14-26-24(17-42-32)28(39-11-8-30(39)9-12-40-18-30)37-29(36-26)41-19-31-6-2-10-38(31)16-21(33)13-31/h3-4,20-21H,2,5-14,16-19,35H2,1H3	DGUONHWWQZQJLK-UHFFFAOYSA-N	436927	(1S,4S)-7-Amino-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-4-methyl-4'-(6-oxa-1-azaspiro[3.4]octan-1-yl)-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidine]-8-carbonitrile ::US20260022132, Compound 598a	GTPase KRas [G12V]	Homo sapiens			 0.190						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436927	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436927&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493753	439658556							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212200	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC[C@@]45CCOC5)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H39FN6O3/c1-20-5-7-32(27-22(20)3-4-25(35)23(27)15-34)14-26-24(17-42-32)28(39-11-8-30(39)9-12-40-18-30)37-29(36-26)41-19-31-6-2-10-38(31)16-21(33)13-31/h3-4,20-21H,2,5-14,16-19,35H2,1H3	DGUONHWWQZQJLK-UHFFFAOYSA-N	436928	(1S,4S)-7-amino-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-4-methyl-4'-((S)-6-oxa-1-azaspiro[3.4]octan-1-yl)-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidine]-8-carbonitrile ::US20260022132, Compound 598b	GTPase KRas [G12V]	Homo sapiens			 0.033						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436928	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436928&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493898	439658557							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212201	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC[C@@]45CCOC5)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H39FN6O3/c1-20-5-7-32(27-22(20)3-4-25(35)23(27)15-34)14-26-24(17-42-32)28(39-11-8-30(39)9-12-40-18-30)37-29(36-26)41-19-31-6-2-10-38(31)16-21(33)13-31/h3-4,20-21H,2,5-14,16-19,35H2,1H3	DGUONHWWQZQJLK-UHFFFAOYSA-N	436928	(1S,4S)-7-amino-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-4-methyl-4'-((S)-6-oxa-1-azaspiro[3.4]octan-1-yl)-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidine]-8-carbonitrile ::US20260022132, Compound 598b	GTPase KRas [G12V]	Homo sapiens			 0.100						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436928	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436928&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493898	439658557							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212202	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC[C@]45CCOC5)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H39FN6O3/c1-20-5-7-32(27-22(20)3-4-25(35)23(27)15-34)14-26-24(17-42-32)28(39-11-8-30(39)9-12-40-18-30)37-29(36-26)41-19-31-6-2-10-38(31)16-21(33)13-31/h3-4,20-21H,2,5-14,16-19,35H2,1H3	DGUONHWWQZQJLK-UHFFFAOYSA-N	436929	(1S,4S)-7-amino-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-4-methyl-4'-((R)-6-oxa-1-azaspiro[3.4]octan-1-yl)-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidine]-8-carbonitrile ::US20260022132, Compound 598c	GTPase KRas [G12V]	Homo sapiens			 0.130						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436929	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436929&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493614	439658558							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212203	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC[C@]45CCOC5)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H39FN6O3/c1-20-5-7-32(27-22(20)3-4-25(35)23(27)15-34)14-26-24(17-42-32)28(39-11-8-30(39)9-12-40-18-30)37-29(36-26)41-19-31-6-2-10-38(31)16-21(33)13-31/h3-4,20-21H,2,5-14,16-19,35H2,1H3	DGUONHWWQZQJLK-UHFFFAOYSA-N	436929	(1S,4S)-7-amino-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-4-methyl-4'-((R)-6-oxa-1-azaspiro[3.4]octan-1-yl)-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidine]-8-carbonitrile ::US20260022132, Compound 598c	GTPase KRas [G12V]	Homo sapiens			 1.60						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436929	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436929&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493614	439658558							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212204	CO[C@@H]1CN2CCC[C@]2(COc2nc3c(c(N4CCC45COC5)n2)CO[C@@]2(CC[C@H](C)c4ccc(N)c(C#N)c42)C3)C1	InChI=1S/C32H40N6O4/c1-20-6-8-32(27-22(20)4-5-25(34)23(27)14-33)13-26-24(16-42-32)28(38-11-9-31(38)17-40-18-31)36-29(35-26)41-19-30-7-3-10-37(30)15-21(12-30)39-2/h4-5,20-21H,3,6-13,15-19,34H2,1-2H3	PTDGGNQLVBBFIK-UHFFFAOYSA-N	436930	US20260022132, Compound 599a	GTPase KRas [G12V]	Homo sapiens			 45.0						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436930	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436930&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493747	439658559							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212205	CO[C@H]1CN2CCC[C@@]2(COc2nc3c(c(N4CCC45COC5)n2)CO[C@@]2(CC[C@H](C)c4ccc(N)c(C#N)c42)C3)C1	InChI=1S/C32H40N6O4/c1-20-6-8-32(27-22(20)4-5-25(34)23(27)14-33)13-26-24(16-42-32)28(38-11-9-31(38)17-40-18-31)36-29(35-26)41-19-30-7-3-10-37(30)15-21(12-30)39-2/h4-5,20-21H,3,6-13,15-19,34H2,1-2H3	PTDGGNQLVBBFIK-UHFFFAOYSA-N	436931	US20260022132, Compound 599b	GTPase KRas [G12V]	Homo sapiens			 0.150						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436931	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436931&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134494039	439658560							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212206	CO[C@H]1CN2CCC[C@@]2(COc2nc3c(c(N4CCC45COC5)n2)CO[C@@]2(CC[C@H](C)c4ccc(N)c(C#N)c42)C3)C1	InChI=1S/C32H40N6O4/c1-20-6-8-32(27-22(20)4-5-25(34)23(27)14-33)13-26-24(16-42-32)28(38-11-9-31(38)17-40-18-31)36-29(35-26)41-19-30-7-3-10-37(30)15-21(12-30)39-2/h4-5,20-21H,3,6-13,15-19,34H2,1-2H3	PTDGGNQLVBBFIK-UHFFFAOYSA-N	436931	US20260022132, Compound 599b	GTPase KRas [G12V]	Homo sapiens			 0.810						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436931	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436931&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134494039	439658560							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212207	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4C(=O)C[C@]45CCCOC5)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C33H39FN6O4/c1-20-6-9-33(28-22(20)4-5-25(36)23(28)15-35)13-26-24(17-44-33)29(40-27(41)14-32(40)8-3-11-42-18-32)38-30(37-26)43-19-31-7-2-10-39(31)16-21(34)12-31/h4-5,20-21H,2-3,6-14,16-19,36H2,1H3	RIONOUVYDULSNP-UHFFFAOYSA-N	436932	US20260022132, Compound 600a	GTPase KRas [G12V]	Homo sapiens			 0.920						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436932	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436932&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493756	439658561							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212208	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4C(=O)C[C@]45CCCOC5)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C33H39FN6O4/c1-20-6-9-33(28-22(20)4-5-25(36)23(28)15-35)13-26-24(17-44-33)29(40-27(41)14-32(40)8-3-11-42-18-32)38-30(37-26)43-19-31-7-2-10-39(31)16-21(34)12-31/h4-5,20-21H,2-3,6-14,16-19,36H2,1H3	RIONOUVYDULSNP-UHFFFAOYSA-N	436932	US20260022132, Compound 600a	GTPase KRas [G12V]	Homo sapiens			 10.00						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436932	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436932&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493756	439658561							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212209	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4C(=O)C[C@@]45CCCOC5)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C33H39FN6O4/c1-20-6-9-33(28-22(20)4-5-25(36)23(28)15-35)13-26-24(17-44-33)29(40-27(41)14-32(40)8-3-11-42-18-32)38-30(37-26)43-19-31-7-2-10-39(31)16-21(34)12-31/h4-5,20-21H,2-3,6-14,16-19,36H2,1H3	RIONOUVYDULSNP-UHFFFAOYSA-N	436933	US20260022132, Compound 600b	GTPase KRas [G12V]	Homo sapiens			 0.078						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436933	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436933&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493608	439658562							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212210	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4C(=O)C[C@@]45CCCOC5)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C33H39FN6O4/c1-20-6-9-33(28-22(20)4-5-25(36)23(28)15-35)13-26-24(17-44-33)29(40-27(41)14-32(40)8-3-11-42-18-32)38-30(37-26)43-19-31-7-2-10-39(31)16-21(34)12-31/h4-5,20-21H,2-3,6-14,16-19,36H2,1H3	RIONOUVYDULSNP-UHFFFAOYSA-N	436933	US20260022132, Compound 600b	GTPase KRas [G12V]	Homo sapiens			 0.610						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436933	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436933&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493608	439658562							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212211	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCC45CCCCC5)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C34H43FN6O2/c1-22-8-12-34(29-24(22)6-7-27(37)25(29)18-36)17-28-26(20-43-34)30(41-15-13-32(41)9-3-2-4-10-32)39-31(38-28)42-21-33-11-5-14-40(33)19-23(35)16-33/h6-7,22-23H,2-5,8-17,19-21,37H2,1H3	PQJLPACRZXKYGZ-UHFFFAOYSA-N	436934	US20260022132, Compound 601a	GTPase KRas [G12V]	Homo sapiens			 1.50						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436934	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436934&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493821	439658563							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212212	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCC45CCCCC5)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C34H43FN6O2/c1-22-8-12-34(29-24(22)6-7-27(37)25(29)18-36)17-28-26(20-43-34)30(41-15-13-32(41)9-3-2-4-10-32)39-31(38-28)42-21-33-11-5-14-40(33)19-23(35)16-33/h6-7,22-23H,2-5,8-17,19-21,37H2,1H3	PQJLPACRZXKYGZ-UHFFFAOYSA-N	436934	US20260022132, Compound 601a	GTPase KRas [G12V]	Homo sapiens			 4.90						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436934	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436934&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493821	439658563							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212213	CN(C)C(=O)c1nn2c(c1Cl)CN(c1nc(OC[C@@]34CCCN3C[C@H](F)C4)nc3c1COC1(CCC4(CC4)c4ccc(N)c(C#N)c41)C3)CCC2	InChI=1S/C37H43ClFN9O3/c1-45(2)33(49)31-30(38)28-19-46(12-4-14-48(28)44-31)32-24-20-51-37(11-10-35(8-9-35)25-5-6-26(41)23(17-40)29(25)37)16-27(24)42-34(43-32)50-21-36-7-3-13-47(36)18-22(39)15-36/h5-6,22H,3-4,7-16,18-21,41H2,1-2H3	QKKGUHKIOUDNHE-UHFFFAOYSA-N	436935	US20260022132, Compound 602a	GTPase KRas [G12V]	Homo sapiens			 0.063						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436935	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436935&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493872	439658564							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212214	CN(C)C(=O)c1nn2c(c1Cl)CN(c1nc(OC[C@@]34CCCN3C[C@H](F)C4)nc3c1COC1(CCC4(CC4)c4ccc(N)c(C#N)c41)C3)CCC2	InChI=1S/C37H43ClFN9O3/c1-45(2)33(49)31-30(38)28-19-46(12-4-14-48(28)44-31)32-24-20-51-37(11-10-35(8-9-35)25-5-6-26(41)23(17-40)29(25)37)16-27(24)42-34(43-32)50-21-36-7-3-13-47(36)18-22(39)15-36/h5-6,22H,3-4,7-16,18-21,41H2,1-2H3	QKKGUHKIOUDNHE-UHFFFAOYSA-N	436935	US20260022132, Compound 602a	GTPase KRas [G12V]	Homo sapiens			 0.900						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436935	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436935&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493872	439658564							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212215	N#Cc1c(N)ccc2c1[C@]1(CCC23CC3)Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc(N3CCC34COC4)c2CO1	InChI=1S/C32H37FN6O3/c33-20-12-30(4-1-10-38(30)15-20)19-41-28-36-25-13-32(42-16-22(25)27(37-28)39-11-9-31(39)17-40-18-31)8-7-29(5-6-29)23-2-3-24(35)21(14-34)26(23)32/h2-3,20H,1,4-13,15-19,35H2	MXFSKZPCOJYMTD-UHFFFAOYSA-N	436936	US20260022132, Compound 603a	GTPase KRas [G12V]	Homo sapiens			>500						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436936	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436936&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493787	439658565							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212216	N#Cc1c(N)ccc2c1[C@]1(CCC23CC3)Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc(N3CCC34COC4)c2CO1	InChI=1S/C32H37FN6O3/c33-20-12-30(4-1-10-38(30)15-20)19-41-28-36-25-13-32(42-16-22(25)27(37-28)39-11-9-31(39)17-40-18-31)8-7-29(5-6-29)23-2-3-24(35)21(14-34)26(23)32/h2-3,20H,1,4-13,15-19,35H2	MXFSKZPCOJYMTD-UHFFFAOYSA-N	436936	US20260022132, Compound 603a	GTPase KRas [G12V]	Homo sapiens			>500						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436936	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436936&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493787	439658565							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212217	N#Cc1c(N)ccc2c1[C@@]1(CCC23CC3)Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc(N3CCC34COC4)c2CO1	InChI=1S/C32H37FN6O3/c33-20-12-30(4-1-10-38(30)15-20)19-41-28-36-25-13-32(42-16-22(25)27(37-28)39-11-9-31(39)17-40-18-31)8-7-29(5-6-29)23-2-3-24(35)21(14-34)26(23)32/h2-3,20H,1,4-13,15-19,35H2	MXFSKZPCOJYMTD-UHFFFAOYSA-N	436937	US20260022132, Compound 603b	GTPase KRas [G12V]	Homo sapiens			 1.90						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436937	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436937&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134494049	439658566							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212218	N#Cc1c(N)ccc2c1[C@@]1(CCC23CC3)Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc(N3CCC34COC4)c2CO1	InChI=1S/C32H37FN6O3/c33-20-12-30(4-1-10-38(30)15-20)19-41-28-36-25-13-32(42-16-22(25)27(37-28)39-11-9-31(39)17-40-18-31)8-7-29(5-6-29)23-2-3-24(35)21(14-34)26(23)32/h2-3,20H,1,4-13,15-19,35H2	MXFSKZPCOJYMTD-UHFFFAOYSA-N	436937	US20260022132, Compound 603b	GTPase KRas [G12V]	Homo sapiens			 17.0						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436937	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436937&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134494049	439658566							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212219	C[C@H]1CCC2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCCn5nc(C(=O)N(C)C)c(Cl)c5C4)c3CO2)c2c1ccc(O)c2C#N	InChI=1S/C36H42ClFN8O4/c1-21-8-10-36(29-23(21)6-7-28(47)24(29)16-39)15-26-25(19-50-36)32(41-34(40-26)49-20-35-9-4-12-45(35)17-22(38)14-35)44-11-5-13-46-27(18-44)30(37)31(42-46)33(48)43(2)3/h6-7,21-22,47H,4-5,8-15,17-20H2,1-3H3	KIIAARLEFZTUIU-UHFFFAOYSA-N	436938	US20260022132, Compound 604a	GTPase KRas [G12V]	Homo sapiens			 0.150						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436938	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436938&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493712	439658567							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212220	C[C@H]1CCC2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCCn5nc(C(=O)N(C)C)c(Cl)c5C4)c3CO2)c2c1ccc(O)c2C#N	InChI=1S/C36H42ClFN8O4/c1-21-8-10-36(29-23(21)6-7-28(47)24(29)16-39)15-26-25(19-50-36)32(41-34(40-26)49-20-35-9-4-12-45(35)17-22(38)14-35)44-11-5-13-46-27(18-44)30(37)31(42-46)33(48)43(2)3/h6-7,21-22,47H,4-5,8-15,17-20H2,1-3H3	KIIAARLEFZTUIU-UHFFFAOYSA-N	436938	US20260022132, Compound 604a	GTPase KRas [G12V]	Homo sapiens			 1.80						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436938	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436938&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493712	439658567							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212221	C[C@H]1CC[C@@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCCn5nc(C(=O)N(C)C)c(Cl)c5C4)c3CO2)c2c1ccc(O)c2C#N	InChI=1S/C36H42ClFN8O4/c1-21-8-10-36(29-23(21)6-7-28(47)24(29)16-39)15-26-25(19-50-36)32(41-34(40-26)49-20-35-9-4-12-45(35)17-22(38)14-35)44-11-5-13-46-27(18-44)30(37)31(42-46)33(48)43(2)3/h6-7,21-22,47H,4-5,8-15,17-20H2,1-3H3	KIIAARLEFZTUIU-UHFFFAOYSA-N	436939	US20260022132, Compound 604b	GTPase KRas [G12V]	Homo sapiens			>500						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436939	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436939&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493823	439658568							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212222	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCCn5nc(C(=O)N(C)C)c(Cl)c5C4)c3CO2)c2c1ccc(O)c2C#N	InChI=1S/C36H42ClFN8O4/c1-21-8-10-36(29-23(21)6-7-28(47)24(29)16-39)15-26-25(19-50-36)32(41-34(40-26)49-20-35-9-4-12-45(35)17-22(38)14-35)44-11-5-13-46-27(18-44)30(37)31(42-46)33(48)43(2)3/h6-7,21-22,47H,4-5,8-15,17-20H2,1-3H3	KIIAARLEFZTUIU-UHFFFAOYSA-N	436940	US20260022132, Compound 604c	GTPase KRas [G12V]	Homo sapiens			 1.60						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436940	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436940&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493802	439658569							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212223	C[C@H]1CCC2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCC45COC5)c3CO2)c2c1ccc(O)c2C#N	InChI=1S/C31H36FN5O4/c1-19-5-7-31(26-21(19)3-4-25(38)22(26)13-33)12-24-23(15-41-31)27(37-10-8-30(37)16-39-17-30)35-28(34-24)40-18-29-6-2-9-36(29)14-20(32)11-29/h3-4,19-20,38H,2,5-12,14-18H2,1H3	NHQOMQRPZLARES-UHFFFAOYSA-N	436941	US20260022132, Compound 605a	GTPase KRas [G12V]	Homo sapiens			 6.60						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436941	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436941&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493845	439658570							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212224	C[C@H]1CCC2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCC45COC5)c3CO2)c2c1ccc(O)c2C#N	InChI=1S/C31H36FN5O4/c1-19-5-7-31(26-21(19)3-4-25(38)22(26)13-33)12-24-23(15-41-31)27(37-10-8-30(37)16-39-17-30)35-28(34-24)40-18-29-6-2-9-36(29)14-20(32)11-29/h3-4,19-20,38H,2,5-12,14-18H2,1H3	NHQOMQRPZLARES-UHFFFAOYSA-N	436941	US20260022132, Compound 605a	GTPase KRas [G12V]	Homo sapiens			 58.0						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436941	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436941&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493845	439658570							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212225	C[C@H]1CC[C@@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCC45COC5)c3CO2)c2c1ccc(O)c2C#N	InChI=1S/C31H36FN5O4/c1-19-5-7-31(26-21(19)3-4-25(38)22(26)13-33)12-24-23(15-41-31)27(37-10-8-30(37)16-39-17-30)35-28(34-24)40-18-29-6-2-9-36(29)14-20(32)11-29/h3-4,19-20,38H,2,5-12,14-18H2,1H3	NHQOMQRPZLARES-UHFFFAOYSA-N	436942	US20260022132, Compound 605b	GTPase KRas [G12V]	Homo sapiens			>500						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436942	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436942&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493915	439658571							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212226	C[C@H]1CC[C@@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCC45COC5)c3CO2)c2c1ccc(O)c2C#N	InChI=1S/C31H36FN5O4/c1-19-5-7-31(26-21(19)3-4-25(38)22(26)13-33)12-24-23(15-41-31)27(37-10-8-30(37)16-39-17-30)35-28(34-24)40-18-29-6-2-9-36(29)14-20(32)11-29/h3-4,19-20,38H,2,5-12,14-18H2,1H3	NHQOMQRPZLARES-UHFFFAOYSA-N	436942	US20260022132, Compound 605b	GTPase KRas [G12V]	Homo sapiens			>500						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436942	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436942&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493915	439658571							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212227	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCC45COC5)c3CO2)c2c1ccc(O)c2C#N	InChI=1S/C31H36FN5O4/c1-19-5-7-31(26-21(19)3-4-25(38)22(26)13-33)12-24-23(15-41-31)27(37-10-8-30(37)16-39-17-30)35-28(34-24)40-18-29-6-2-9-36(29)14-20(32)11-29/h3-4,19-20,38H,2,5-12,14-18H2,1H3	NHQOMQRPZLARES-UHFFFAOYSA-N	436943	US20260022132, Compound 605c	GTPase KRas [G12V]	Homo sapiens			 4.10						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436943	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436943&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493851	439658572							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212228	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCC45COC5)c3CO2)c2c1ccc(O)c2C#N	InChI=1S/C31H36FN5O4/c1-19-5-7-31(26-21(19)3-4-25(38)22(26)13-33)12-24-23(15-41-31)27(37-10-8-30(37)16-39-17-30)35-28(34-24)40-18-29-6-2-9-36(29)14-20(32)11-29/h3-4,19-20,38H,2,5-12,14-18H2,1H3	NHQOMQRPZLARES-UHFFFAOYSA-N	436943	US20260022132, Compound 605c	GTPase KRas [G12V]	Homo sapiens			 57.0						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436943	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436943&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493851	439658572							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212229	CC[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCC45COC5)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H39FN6O3/c1-2-20-6-8-32(27-22(20)4-5-25(35)23(27)14-34)13-26-24(16-42-32)28(39-11-9-31(39)17-40-18-31)37-29(36-26)41-19-30-7-3-10-38(30)15-21(33)12-30/h4-5,20-21H,2-3,6-13,15-19,35H2,1H3	FUDDEEIXGPOEBY-UHFFFAOYSA-N	436944	US20260022132, Compound 606a	GTPase KRas [G12V]	Homo sapiens			 1.000						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436944	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436944&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493806	439658573							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212230	CC[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCC45COC5)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H39FN6O3/c1-2-20-6-8-32(27-22(20)4-5-25(35)23(27)14-34)13-26-24(16-42-32)28(39-11-9-31(39)17-40-18-31)37-29(36-26)41-19-30-7-3-10-38(30)15-21(33)12-30/h4-5,20-21H,2-3,6-13,15-19,35H2,1H3	FUDDEEIXGPOEBY-UHFFFAOYSA-N	436944	US20260022132, Compound 606a	GTPase KRas [G12V]	Homo sapiens			 14.0						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436944	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436944&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493806	439658573							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212231	CC[C@H]1CC[C@@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCC45COC5)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H39FN6O3/c1-2-20-6-8-32(27-22(20)4-5-25(35)23(27)14-34)13-26-24(16-42-32)28(39-11-9-31(39)17-40-18-31)37-29(36-26)41-19-30-7-3-10-38(30)15-21(33)12-30/h4-5,20-21H,2-3,6-13,15-19,35H2,1H3	FUDDEEIXGPOEBY-UHFFFAOYSA-N	436945	US20260022132, Compound 606b	GTPase KRas [G12V]	Homo sapiens			>500						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436945	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436945&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493567	439658574							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212232	CC[C@H]1CC[C@@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCC45COC5)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H39FN6O3/c1-2-20-6-8-32(27-22(20)4-5-25(35)23(27)14-34)13-26-24(16-42-32)28(39-11-9-31(39)17-40-18-31)37-29(36-26)41-19-30-7-3-10-38(30)15-21(33)12-30/h4-5,20-21H,2-3,6-13,15-19,35H2,1H3	FUDDEEIXGPOEBY-UHFFFAOYSA-N	436945	US20260022132, Compound 606b	GTPase KRas [G12V]	Homo sapiens			>500						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436945	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436945&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493567	439658574							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212233	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC(CO)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C30H37FN6O3/c1-18-5-7-30(26-21(18)3-4-24(33)22(26)11-32)10-25-23(16-40-30)27(36-12-19(13-36)15-38)35-28(34-25)39-17-29-6-2-8-37(29)14-20(31)9-29/h3-4,18-20,38H,2,5-10,12-17,33H2,1H3	YHIWUUUNNDTMOQ-UHFFFAOYSA-N	436946	(1S,4S)-7-Amino-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-4'-(3-(hydroxymethyl)azetidin-1-yl)-4-methyl-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidine]-8-carbonitrile ::US20260022132, Compound 607a	GTPase KRas [G12V]	Homo sapiens			 2.90						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436946	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436946&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493899	439658575							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212234	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC(CO)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C30H37FN6O3/c1-18-5-7-30(26-21(18)3-4-24(33)22(26)11-32)10-25-23(16-40-30)27(36-12-19(13-36)15-38)35-28(34-25)39-17-29-6-2-8-37(29)14-20(31)9-29/h3-4,18-20,38H,2,5-10,12-17,33H2,1H3	YHIWUUUNNDTMOQ-UHFFFAOYSA-N	436946	(1S,4S)-7-Amino-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-4'-(3-(hydroxymethyl)azetidin-1-yl)-4-methyl-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidine]-8-carbonitrile ::US20260022132, Compound 607a	GTPase KRas [G12V]	Homo sapiens			 35.0						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436946	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436946&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493899	439658575							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212235	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4C(=O)C[C@@]45CCOC5)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H37FN6O4/c1-19-5-7-32(27-21(19)3-4-24(35)22(27)14-34)12-25-23(16-43-32)28(39-26(40)13-31(39)8-10-41-17-31)37-29(36-25)42-18-30-6-2-9-38(30)15-20(33)11-30/h3-4,19-20H,2,5-13,15-18,35H2,1H3	ZPWKIVPVCLLXRS-UHFFFAOYSA-N	436947	US20260022132, Compound 608a	GTPase KRas [G12V]	Homo sapiens			 0.050						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436947	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436947&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493618	439658576							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212236	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4C(=O)C[C@@]45CCOC5)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H37FN6O4/c1-19-5-7-32(27-21(19)3-4-24(35)22(27)14-34)12-25-23(16-43-32)28(39-26(40)13-31(39)8-10-41-17-31)37-29(36-25)42-18-30-6-2-9-38(30)15-20(33)11-30/h3-4,19-20H,2,5-13,15-18,35H2,1H3	ZPWKIVPVCLLXRS-UHFFFAOYSA-N	436947	US20260022132, Compound 608a	GTPase KRas [G12V]	Homo sapiens			 0.390						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436947	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436947&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493618	439658576							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212237	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4C(=O)C[C@]45CCOC5)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H37FN6O4/c1-19-5-7-32(27-21(19)3-4-24(35)22(27)14-34)12-25-23(16-43-32)28(39-26(40)13-31(39)8-10-41-17-31)37-29(36-25)42-18-30-6-2-9-38(30)15-20(33)11-30/h3-4,19-20H,2,5-13,15-18,35H2,1H3	ZPWKIVPVCLLXRS-UHFFFAOYSA-N	436948	US20260022132, Compound 608b	GTPase KRas [G12V]	Homo sapiens			 0.180						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436948	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436948&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134494056	439658577							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212238	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4C(=O)C[C@]45CCOC5)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H37FN6O4/c1-19-5-7-32(27-21(19)3-4-24(35)22(27)14-34)12-25-23(16-43-32)28(39-26(40)13-31(39)8-10-41-17-31)37-29(36-25)42-18-30-6-2-9-38(30)15-20(33)11-30/h3-4,19-20H,2,5-13,15-18,35H2,1H3	ZPWKIVPVCLLXRS-UHFFFAOYSA-N	436948	US20260022132, Compound 608b	GTPase KRas [G12V]	Homo sapiens			 2.50						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436948	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436948&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134494056	439658577							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212239	CC[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCC4(CO)CO)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H41FN6O4/c1-2-20-6-8-32(27-22(20)4-5-25(35)23(27)14-34)13-26-24(16-43-32)28(39-11-9-31(39,17-40)18-41)37-29(36-26)42-19-30-7-3-10-38(30)15-21(33)12-30/h4-5,20-21,40-41H,2-3,6-13,15-19,35H2,1H3	XMCFWJNJDSTPHW-UHFFFAOYSA-N	436949	US20260022132, Compound 609a	GTPase KRas [G12V]	Homo sapiens			 0.320						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436949	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436949&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493615	439658578							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212240	CC[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCC4(CO)CO)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H41FN6O4/c1-2-20-6-8-32(27-22(20)4-5-25(35)23(27)14-34)13-26-24(16-43-32)28(39-11-9-31(39,17-40)18-41)37-29(36-26)42-19-30-7-3-10-38(30)15-21(33)12-30/h4-5,20-21,40-41H,2-3,6-13,15-19,35H2,1H3	XMCFWJNJDSTPHW-UHFFFAOYSA-N	436949	US20260022132, Compound 609a	GTPase KRas [G12V]	Homo sapiens			 4.30						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436949	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436949&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493615	439658578							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212241	CC[C@H]1CC[C@@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCC4(CO)CO)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H41FN6O4/c1-2-20-6-8-32(27-22(20)4-5-25(35)23(27)14-34)13-26-24(16-43-32)28(39-11-9-31(39,17-40)18-41)37-29(36-26)42-19-30-7-3-10-38(30)15-21(33)12-30/h4-5,20-21,40-41H,2-3,6-13,15-19,35H2,1H3	XMCFWJNJDSTPHW-UHFFFAOYSA-N	436950	US20260022132, Compound 609b	GTPase KRas [G12V]	Homo sapiens			 21.0						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436950	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436950&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493732	439658579							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212242	C[C@H](O)[C@H]1CCN1c1nc(OC[C@@]23CCCN2C[C@H](F)C3)nc2c1CO[C@@]1(CC[C@H](C)c3ccc(N)c(C#N)c31)C2	InChI=1S/C31H39FN6O3/c1-18-6-9-31(27-21(18)4-5-24(34)22(27)14-33)13-25-23(16-41-31)28(38-11-7-26(38)19(2)39)36-29(35-25)40-17-30-8-3-10-37(30)15-20(32)12-30/h4-5,18-20,26,39H,3,6-13,15-17,34H2,1-2H3	VUTJVMWIEMNLBI-UHFFFAOYSA-N	436951	US20260022132, Compound 610a	GTPase KRas [G12V]	Homo sapiens			 0.990						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436951	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436951&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134494038	439658580							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212243	C[C@H](O)[C@H]1CCN1c1nc(OC[C@@]23CCCN2C[C@H](F)C3)nc2c1CO[C@@]1(CC[C@H](C)c3ccc(N)c(C#N)c31)C2	InChI=1S/C31H39FN6O3/c1-18-6-9-31(27-21(18)4-5-24(34)22(27)14-33)13-25-23(16-41-31)28(38-11-7-26(38)19(2)39)36-29(35-25)40-17-30-8-3-10-37(30)15-20(32)12-30/h4-5,18-20,26,39H,3,6-13,15-17,34H2,1-2H3	VUTJVMWIEMNLBI-UHFFFAOYSA-N	436951	US20260022132, Compound 610a	GTPase KRas [G12V]	Homo sapiens			 7.80						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436951	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436951&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134494038	439658580							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212244	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC[C@@H]4[C@@H](C)O)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C31H39FN6O3/c1-18-6-9-31(27-21(18)4-5-24(34)22(27)14-33)13-25-23(16-41-31)28(38-11-7-26(38)19(2)39)36-29(35-25)40-17-30-8-3-10-37(30)15-20(32)12-30/h4-5,18-20,26,39H,3,6-13,15-17,34H2,1-2H3	VUTJVMWIEMNLBI-UHFFFAOYSA-N	436952	US20260022132, Compound 610b	GTPase KRas [G12V]	Homo sapiens			 1.50						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436952	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436952&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134494050	439658581							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212245	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC(F)(F)[C@@H]4CO)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C30H35F3N6O3/c1-17-5-7-29(25-19(17)3-4-22(35)20(25)11-34)10-23-21(14-42-29)26(39-15-30(32,33)24(39)13-40)37-27(36-23)41-16-28-6-2-8-38(28)12-18(31)9-28/h3-4,17-18,24,40H,2,5-10,12-16,35H2,1H3	DQAHXKQVGLPZCV-UHFFFAOYSA-N	436953	US20260022132, Compound 611a	GTPase KRas [G12V]	Homo sapiens			 0.080						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436953	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436953&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493759	439658582							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212246	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC(F)(F)[C@@H]4CO)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C30H35F3N6O3/c1-17-5-7-29(25-19(17)3-4-22(35)20(25)11-34)10-23-21(14-42-29)26(39-15-30(32,33)24(39)13-40)37-27(36-23)41-16-28-6-2-8-38(28)12-18(31)9-28/h3-4,17-18,24,40H,2,5-10,12-16,35H2,1H3	DQAHXKQVGLPZCV-UHFFFAOYSA-N	436953	US20260022132, Compound 611a	GTPase KRas [G12V]	Homo sapiens			 0.580						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436953	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436953&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493759	439658582							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212247	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC(F)(F)[C@H]4CO)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C30H35F3N6O3/c1-17-5-7-29(25-19(17)3-4-22(35)20(25)11-34)10-23-21(14-42-29)26(39-15-30(32,33)24(39)13-40)37-27(36-23)41-16-28-6-2-8-38(28)12-18(31)9-28/h3-4,17-18,24,40H,2,5-10,12-16,35H2,1H3	DQAHXKQVGLPZCV-UHFFFAOYSA-N	436954	US20260022132, Compound 611b	GTPase KRas [G12V]	Homo sapiens			 1.10						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436954	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436954&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493754	439658583							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212248	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC(F)(F)[C@H]4CO)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C30H35F3N6O3/c1-17-5-7-29(25-19(17)3-4-22(35)20(25)11-34)10-23-21(14-42-29)26(39-15-30(32,33)24(39)13-40)37-27(36-23)41-16-28-6-2-8-38(28)12-18(31)9-28/h3-4,17-18,24,40H,2,5-10,12-16,35H2,1H3	DQAHXKQVGLPZCV-UHFFFAOYSA-N	436954	US20260022132, Compound 611b	GTPase KRas [G12V]	Homo sapiens			 10.00						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436954	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436954&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493754	439658583							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212249	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC[C@@H]4C)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C30H37FN6O2/c1-18-6-9-30(26-21(18)4-5-24(33)22(26)14-32)13-25-23(16-39-30)27(37-11-7-19(37)2)35-28(34-25)38-17-29-8-3-10-36(29)15-20(31)12-29/h4-5,18-20H,3,6-13,15-17,33H2,1-2H3	VSILTRBGRFUVGT-UHFFFAOYSA-N	436955	US20260022132, Compound 612a	GTPase KRas [G12V]	Homo sapiens			 1.40						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436955	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436955&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493834	439658584							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212250	C[C@@H]1CCN1c1nc(OC[C@@]23CCCN2C[C@H](F)C3)nc2c1CO[C@@]1(CC[C@H](C)c3ccc(N)c(C#N)c31)C2	InChI=1S/C30H37FN6O2/c1-18-6-9-30(26-21(18)4-5-24(33)22(26)14-32)13-25-23(16-39-30)27(37-11-7-19(37)2)35-28(34-25)38-17-29-8-3-10-36(29)15-20(31)12-29/h4-5,18-20H,3,6-13,15-17,33H2,1-2H3	VSILTRBGRFUVGT-UHFFFAOYSA-N	436956	US20260022132, Compound 612b	GTPase KRas [G12V]	Homo sapiens			 3.10						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436956	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436956&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493895	439658585							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212251	C[C@@H]1C[C@H](C)N1c1nc(OC[C@@]23CCCN2CC(F)C3)nc2c1CO[C@@]1(CC[C@H](C)c3ccc(N)c(C#N)c31)C2	InChI=1S/C31H39FN6O2/c1-18-7-9-31(27-22(18)5-6-25(34)23(27)14-33)13-26-24(16-40-31)28(38-19(2)11-20(38)3)36-29(35-26)39-17-30-8-4-10-37(30)15-21(32)12-30/h5-6,18-21H,4,7-13,15-17,34H2,1-3H3	CGQLDBBSNPEJAS-UHFFFAOYSA-N	436957	US20260022132, Compound 613a	GTPase KRas [G12V]	Homo sapiens			 1.10						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436957	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436957&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493804	439658586							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212252	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4[C@@H](C)C[C@@H]4C)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C31H39FN6O2/c1-18-7-9-31(27-22(18)5-6-25(34)23(27)14-33)13-26-24(16-40-31)28(38-19(2)11-20(38)3)36-29(35-26)39-17-30-8-4-10-37(30)15-21(32)12-30/h5-6,18-21H,4,7-13,15-17,34H2,1-3H3	CGQLDBBSNPEJAS-UHFFFAOYSA-N	436958	US20260022132, Compound 613b	GTPase KRas [G12V]	Homo sapiens			 0.680						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436958	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436958&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493881	439658587							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212253	C[C@@H]1C[C@@H](C)N1c1nc(OC[C@@]23CCCN2C[C@H](F)C3)nc2c1CO[C@@]1(CC[C@H](C)c3ccc(N)c(C#N)c31)C2	InChI=1S/C31H39FN6O2/c1-18-7-9-31(27-22(18)5-6-25(34)23(27)14-33)13-26-24(16-40-31)28(38-19(2)11-20(38)3)36-29(35-26)39-17-30-8-4-10-37(30)15-21(32)12-30/h5-6,18-21H,4,7-13,15-17,34H2,1-3H3	CGQLDBBSNPEJAS-UHFFFAOYSA-N	436959	US20260022132, Compound 613c	GTPase KRas [G12V]	Homo sapiens			 7.50						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436959	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436959&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493619	439658588							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212254	CC[C@H]1CCC2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCCn5nc(C(=O)N(C)C)c(Cl)c5C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C37H45ClFN9O3/c1-4-22-9-11-37(30-24(22)7-8-27(41)25(30)17-40)16-28-26(20-51-37)33(43-35(42-28)50-21-36-10-5-13-47(36)18-23(39)15-36)46-12-6-14-48-29(19-46)31(38)32(44-48)34(49)45(2)3/h7-8,22-23H,4-6,9-16,18-21,41H2,1-3H3	WTLGBYAJYMCSFK-UHFFFAOYSA-N	436960	US20260022132, Compound 614a	GTPase KRas [G12V]	Homo sapiens			 0.590						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436960	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436960&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134494063	439658589							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212255	CC[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCCn5nc(C(=O)N(C)C)c(Cl)c5C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C37H45ClFN9O3/c1-4-22-9-11-37(30-24(22)7-8-27(41)25(30)17-40)16-28-26(20-51-37)33(43-35(42-28)50-21-36-10-5-13-47(36)18-23(39)15-36)46-12-6-14-48-29(19-46)31(38)32(44-48)34(49)45(2)3/h7-8,22-23H,4-6,9-16,18-21,41H2,1-3H3	WTLGBYAJYMCSFK-UHFFFAOYSA-N	436961	US20260022132, Compound 614b	GTPase KRas [G12V]	Homo sapiens			 0.690						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436961	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436961&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493598	439658590							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212256	Cc1cc2[nH]ncc2c(-c2ccc3c(N(C)[C@@H]4CCN(C(=O)/C(F)=C/c5nccs5)C4)nc(OC[C@@]45CCCN4C[C@H](F)C5)nc3c2F)c1Cl	InChI=1S/C35H34ClF3N8O2S/c1-19-12-26-24(15-41-44-26)28(29(19)36)22-4-5-23-31(30(22)39)42-34(49-18-35-7-3-9-47(35)16-20(37)14-35)43-32(23)45(2)21-6-10-46(17-21)33(48)25(38)13-27-40-8-11-50-27/h4-5,8,11-13,15,20-21H,3,6-7,9-10,14,16-18H2,1-2H3,(H,41,44)	RUWNSBYLNKSSIN-UHFFFAOYSA-N	436962	US20260022132, Compound 614c	GTPase KRas [G12V]	Homo sapiens			>500						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436962	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436962&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493621	439658591							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212257	C[C@H]1CC[C@]2(Cc3nc(OCCN(C)C)nc(N4CCCn5nc(C(=O)N(C)C)c(Cl)c5C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H40ClN9O3/c1-19-9-10-32(26-20(19)7-8-23(35)21(26)16-34)15-24-22(18-45-32)29(37-31(36-24)44-14-13-39(2)3)41-11-6-12-42-25(17-41)27(33)28(38-42)30(43)40(4)5/h7-8,19H,6,9-15,17-18,35H2,1-5H3	UXFICBYXVNYQGI-UHFFFAOYSA-N	436963	US20260022132, Compound 615a	GTPase KRas [G12V]	Homo sapiens			 23.0						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436963	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436963&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493763	439658592							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212258	C[C@H]1CC[C@]2(Cc3nc(OCCN(C)C)nc(N4CCCn5nc(C(=O)N(C)C)cc5C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H41N9O3/c1-20-9-10-32(28-22(20)7-8-25(34)23(28)17-33)16-27-24(19-44-32)29(36-31(35-27)43-14-13-38(2)3)40-11-6-12-41-21(18-40)15-26(37-41)30(42)39(4)5/h7-8,15,20H,6,9-14,16,18-19,34H2,1-5H3	JEDVJSDFJOULPO-UHFFFAOYSA-N	436964	US20260022132, Compound 616a	GTPase KRas [G12V]	Homo sapiens			 54.0						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436964	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436964&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493758	439658593							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212259	C[C@H]1CC[C@]2(Cc3nc(OCC4(CN(C)C)CC4)nc(N4CCCn5nc(C(=O)N(C)C)c(Cl)c5C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C35H44ClN9O3/c1-21-9-10-35(28-22(21)7-8-25(38)23(28)16-37)15-26-24(18-48-35)31(40-33(39-26)47-20-34(11-12-34)19-42(2)3)44-13-6-14-45-27(17-44)29(36)30(41-45)32(46)43(4)5/h7-8,21H,6,9-15,17-20,38H2,1-5H3	BJRROEWTNCBXGW-UHFFFAOYSA-N	436965	US20260022132, Compound 617a	GTPase KRas [G12V]	Homo sapiens			 0.940						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436965	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436965&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493622	439658594							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212260	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCC[C@@H]4CO)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C31H39FN6O3/c1-19-7-9-31(27-22(19)5-6-25(34)23(27)14-33)13-26-24(17-41-31)28(38-11-2-4-21(38)16-39)36-29(35-26)40-18-30-8-3-10-37(30)15-20(32)12-30/h5-6,19-21,39H,2-4,7-13,15-18,34H2,1H3	IVJDIWPMJKYRKM-UHFFFAOYSA-N	436966	US20260022132, Compound 618a	GTPase KRas [G12V]	Homo sapiens			 0.640						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436966	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436966&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134494058	439658595							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212261	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCC4c4nccs4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H36FN7O2S/c1-19-5-8-32(27-21(19)3-4-24(35)22(27)15-34)14-25-23(17-42-32)28(40-11-6-26(40)29-36-9-12-43-29)38-30(37-25)41-18-31-7-2-10-39(31)16-20(33)13-31/h3-4,9,12,19-20,26H,2,5-8,10-11,13-14,16-18,35H2,1H3	XTQZJPFLRGPFLZ-UHFFFAOYSA-N	436967	US20260022132, Compound 619a	GTPase KRas [G12V]	Homo sapiens			 2.20						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436967	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436967&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493906	439658596							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212262	COC[C@H]1CCCN1c1nc(OC[C@@]23CCCN2C[C@H](F)C3)nc2c1CO[C@@]1(CC[C@H](C)c3ccc(N)c(C#N)c31)C2	InChI=1S/C32H41FN6O3/c1-20-8-10-32(28-23(20)6-7-26(35)24(28)15-34)14-27-25(18-42-32)29(39-12-3-5-22(39)17-40-2)37-30(36-27)41-19-31-9-4-11-38(31)16-21(33)13-31/h6-7,20-22H,3-5,8-14,16-19,35H2,1-2H3	UXPXFHWACDGWEQ-UHFFFAOYSA-N	436968	US20260022132, Compound 620a	GTPase KRas [G12V]	Homo sapiens			 7.50						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436968	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436968&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493744	439658597							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212263	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC[C@H]4c4ncco4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H36FN7O3/c1-19-5-8-32(27-21(19)3-4-24(35)22(27)15-34)14-25-23(17-43-32)28(40-11-6-26(40)29-36-9-12-41-29)38-30(37-25)42-18-31-7-2-10-39(31)16-20(33)13-31/h3-4,9,12,19-20,26H,2,5-8,10-11,13-14,16-18,35H2,1H3	JQDZAUVZQQXCSV-UHFFFAOYSA-N	436969	US20260022132, Compound 621a	GTPase KRas [G12V]	Homo sapiens			 0.570						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436969	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436969&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493856	439658598							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212264	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC[C@@H]4c4ncco4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H36FN7O3/c1-19-5-8-32(27-21(19)3-4-24(35)22(27)15-34)14-25-23(17-43-32)28(40-11-6-26(40)29-36-9-12-41-29)38-30(37-25)42-18-31-7-2-10-39(31)16-20(33)13-31/h3-4,9,12,19-20,26H,2,5-8,10-11,13-14,16-18,35H2,1H3	JQDZAUVZQQXCSV-UHFFFAOYSA-N	436970	US20260022132, Compound 621b	GTPase KRas [G12V]	Homo sapiens			 470						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436970	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436970&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493626	439658599							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212265	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4[C@H](CO)C[C@@H]4CO)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C31H39FN6O4/c1-18-5-7-31(27-22(18)3-4-25(34)23(27)12-33)11-26-24(16-42-31)28(38-20(14-39)9-21(38)15-40)36-29(35-26)41-17-30-6-2-8-37(30)13-19(32)10-30/h3-4,18-21,39-40H,2,5-11,13-17,34H2,1H3	DPLPXAKXIGWDFX-UHFFFAOYSA-N	436971	US20260022132, Compound 622a	GTPase KRas [G12V]	Homo sapiens			 1.90						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436971	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436971&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493623	439658600							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212266	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCC4(C)C)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C31H39FN6O2/c1-19-7-9-31(26-21(19)5-6-24(34)22(26)15-33)14-25-23(17-40-31)27(38-12-10-29(38,2)3)36-28(35-25)39-18-30-8-4-11-37(30)16-20(32)13-30/h5-6,19-20H,4,7-14,16-18,34H2,1-3H3	JZQLTOVZQZAHFT-UHFFFAOYSA-N	436972	US20260022132, Compound 623a	GTPase KRas [G12V]	Homo sapiens			 0.330						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436972	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436972&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493731	439658601							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212267	COC[C@@]1(CO)CCN1c1nc(OC[C@@]23CCCN2C[C@H](F)C3)nc2c1CO[C@@]1(CC[C@H](C)c3ccc(N)c(C#N)c31)C2	InChI=1S/C32H41FN6O4/c1-20-6-8-32(27-22(20)4-5-25(35)23(27)14-34)13-26-24(16-43-32)28(39-11-9-31(39,17-40)18-41-2)37-29(36-26)42-19-30-7-3-10-38(30)15-21(33)12-30/h4-5,20-21,40H,3,6-13,15-19,35H2,1-2H3	AOCHUIYXUYUARC-UHFFFAOYSA-N	436973	US20260022132, Compound 624a	GTPase KRas [G12V]	Homo sapiens			>500						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436973	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436973&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493923	439658602							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212268	COC[C@]1(CO)CCN1c1nc(OC[C@@]23CCCN2C[C@H](F)C3)nc2c1CO[C@@]1(CC[C@H](C)c3ccc(N)c(C#N)c31)C2	InChI=1S/C32H41FN6O4/c1-20-6-8-32(27-22(20)4-5-25(35)23(27)14-34)13-26-24(16-43-32)28(39-11-9-31(39,17-40)18-41-2)37-29(36-26)42-19-30-7-3-10-38(30)15-21(33)12-30/h4-5,20-21,40H,3,6-13,15-19,35H2,1-2H3	AOCHUIYXUYUARC-UHFFFAOYSA-N	436974	US20260022132, Compound 624b	GTPase KRas [G12V]	Homo sapiens			 0.120						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436974	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436974&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493857	439658603							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212269	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCCCC4=O)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C31H37FN6O3/c1-19-8-10-31(27-21(19)6-7-24(34)22(27)15-33)14-25-23(17-41-31)28(38-12-3-2-5-26(38)39)36-29(35-25)40-18-30-9-4-11-37(30)16-20(32)13-30/h6-7,19-20H,2-5,8-14,16-18,34H2,1H3	WKLDJPPYPSNPBE-UHFFFAOYSA-N	436975	US20260022132, Compound 625a	GTPase KRas [G12V]	Homo sapiens			 61.0						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436975	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436975&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493774	439658604							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212270	C[C@H]1CC[C@]2(Cc3nc(OCC45CCCN4C[C@H](F)C5)nc(N4CCCOCC4=O)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C31H37FN6O4/c1-19-6-8-31(27-21(19)4-5-24(34)22(27)14-33)13-25-23(16-42-31)28(38-10-3-11-40-17-26(38)39)36-29(35-25)41-18-30-7-2-9-37(30)15-20(32)12-30/h4-5,19-20H,2-3,6-13,15-18,34H2,1H3	PWVWVJWGDKWNLR-UHFFFAOYSA-N	436976	US20260022132, Compound 626a	GTPase KRas [G12V]	Homo sapiens			 28.0						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436976	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436976&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493988	439658605							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212271	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCCC4=O)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C30H35FN6O3/c1-18-7-9-30(26-20(18)5-6-23(33)21(26)14-32)13-24-22(16-40-30)27(37-11-2-4-25(37)38)35-28(34-24)39-17-29-8-3-10-36(29)15-19(31)12-29/h5-6,18-19H,2-4,7-13,15-17,33H2,1H3	IFOXRFSLHGXTSV-UHFFFAOYSA-N	436977	US20260022132, Compound 627a	GTPase KRas [G12V]	Homo sapiens			 20.0						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436977	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436977&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493918	439658606							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212272	CO[C@H]1CN2CCC[C@@]2(COc2nc3c(c(N4CCCn5nc(C(=O)N(C)C)c(Cl)c5C4)n2)CO[C@@]2(CC[C@H](C)c4ccc(N)c(C#N)c42)C3)C1	InChI=1S/C37H46ClN9O4/c1-22-9-11-37(30-24(22)7-8-27(40)25(30)17-39)16-28-26(20-51-37)33(42-35(41-28)50-21-36-10-5-13-46(36)18-23(15-36)49-4)45-12-6-14-47-29(19-45)31(38)32(43-47)34(48)44(2)3/h7-8,22-23H,5-6,9-16,18-21,40H2,1-4H3	IVPTVHNQKVCOOU-UHFFFAOYSA-N	436979	US20260022132, Compound 628b	GTPase KRas [G12V]	Homo sapiens			 0.033						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436979	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436979&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493920	439658608							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212273	CO[C@@H]1CN2CCC[C@]2(COc2nc3c(c(N4CCCn5nc(C(=O)N(C)C)c(Cl)c5C4)n2)CO[C@@]2(CC[C@H](C)c4ccc(N)c(C#N)c42)C3)C1	InChI=1S/C37H46ClN9O4/c1-22-9-11-37(30-24(22)7-8-27(40)25(30)17-39)16-28-26(20-51-37)33(42-35(41-28)50-21-36-10-5-13-46(36)18-23(15-36)49-4)45-12-6-14-47-29(19-45)31(38)32(43-47)34(48)44(2)3/h7-8,22-23H,5-6,9-16,18-21,40H2,1-4H3	IVPTVHNQKVCOOU-UHFFFAOYSA-N	436980	US20260022132, Compound 628c	GTPase KRas [G12V]	Homo sapiens			 0.050						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436980	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436980&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493757	439658609							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212274	CN(C)C(=O)c1nn2c(c1Cl)CN(c1nc(OC[C@@]34CCCN3CC(F)(F)C4)nc3c1CO[C@@]1(CCCc4ccc(N)c(C#N)c41)C3)CCC2	InChI=1S/C35H40ClF2N9O3/c1-44(2)31(48)29-28(36)26-16-45(11-5-13-47(26)43-29)30-23-17-50-34(10-3-6-21-7-8-24(40)22(15-39)27(21)34)14-25(23)41-32(42-30)49-20-33-9-4-12-46(33)19-35(37,38)18-33/h7-8H,3-6,9-14,16-20,40H2,1-2H3	RBMRGHGQRJSAOA-UHFFFAOYSA-N	436983	US20260022132, Compound 631a	GTPase KRas [G12V]	Homo sapiens			 2.00						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436983	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436983&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134494057	439658612							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212275	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4CC(F)(F)C5)nc(N4CCCn5nc(C(=O)N(C)C)cc5C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C36H43F2N9O3/c1-22-8-10-35(30-24(22)6-7-27(40)25(30)16-39)15-29-26(18-50-35)31(45-11-5-13-47-23(17-45)14-28(43-47)32(48)44(2)3)42-33(41-29)49-21-34-9-4-12-46(34)20-36(37,38)19-34/h6-7,14,22H,4-5,8-13,15,17-21,40H2,1-3H3	GHNPIYQEQFPAIH-UHFFFAOYSA-N	436984	US20260022132, Compound 632a	GTPase KRas [G12V]	Homo sapiens			 9.00						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436984	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436984&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493858	439658613							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212276	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCOCC4=O)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C30H35FN6O4/c1-18-5-7-30(26-20(18)3-4-23(33)21(26)13-32)12-24-22(15-41-30)27(37-9-10-39-16-25(37)38)35-28(34-24)40-17-29-6-2-8-36(29)14-19(31)11-29/h3-4,18-19H,2,5-12,14-17,33H2,1H3	VLFMTNJLXHADIO-UHFFFAOYSA-N	436985	US20260022132, Compound 635a	GTPase KRas [G12V]	Homo sapiens			 14.0						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436985	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436985&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493813	439658614							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212277	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCOCCC4=O)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C31H37FN6O4/c1-19-5-8-31(27-21(19)3-4-24(34)22(27)15-33)14-25-23(17-42-31)28(38-10-12-40-11-6-26(38)39)36-29(35-25)41-18-30-7-2-9-37(30)16-20(32)13-30/h3-4,19-20H,2,5-14,16-18,34H2,1H3	UFYFQRKPTFFKMM-UHFFFAOYSA-N	436986	US20260022132, Compound 636a	GTPase KRas [G12V]	Homo sapiens			 140						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436986	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436986&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493916	439658615							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212278	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCC[C@]4(C)CO)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H41FN6O3/c1-20-7-10-32(27-22(20)5-6-25(35)23(27)15-34)14-26-24(17-42-32)28(39-12-3-8-30(39,2)18-40)37-29(36-26)41-19-31-9-4-11-38(31)16-21(33)13-31/h5-6,20-21,40H,3-4,7-14,16-19,35H2,1-2H3	NEOIEWLVNQDZBU-UHFFFAOYSA-N	436987	US20260022132, Compound 637a	GTPase KRas [G12V]	Homo sapiens			 1.30						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436987	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436987&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490039	439658616							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212279	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCC[C@@]4(C)CO)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H41FN6O3/c1-20-7-10-32(27-22(20)5-6-25(35)23(27)15-34)14-26-24(17-42-32)28(39-12-3-8-30(39,2)18-40)37-29(36-26)41-19-31-9-4-11-38(31)16-21(33)13-31/h5-6,20-21,40H,3-4,7-14,16-19,35H2,1-2H3	NEOIEWLVNQDZBU-UHFFFAOYSA-N	436988	US20260022132, Compound 637b	GTPase KRas [G12V]	Homo sapiens			 4.40						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436988	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436988&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134494064	439658617							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212280	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCCC45COC5)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H39FN6O3/c1-20-6-9-32(27-22(20)4-5-25(35)23(27)14-34)13-26-24(16-42-32)28(39-11-3-8-31(39)17-40-18-31)37-29(36-26)41-19-30-7-2-10-38(30)15-21(33)12-30/h4-5,20-21H,2-3,6-13,15-19,35H2,1H3	IZFDETJGNCHIHJ-UHFFFAOYSA-N	436989	US20260022132, Compound 638a	GTPase KRas [G12V]	Homo sapiens			 6.70						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436989	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436989&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493599	439658618							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212281	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC(C)(C)[C@@H]4CO)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H41FN6O3/c1-19-7-9-32(27-21(19)5-6-24(35)22(27)13-34)12-25-23(16-42-32)28(39-17-30(2,3)26(39)15-40)37-29(36-25)41-18-31-8-4-10-38(31)14-20(33)11-31/h5-6,19-20,26,40H,4,7-12,14-18,35H2,1-3H3	HTOYXIRZIQWTFM-UHFFFAOYSA-N	436992	US20260022132, Compound 639a	GTPase KRas [G12V]	Homo sapiens			 32.0						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436992	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436992&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134494068	439658621							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212282	C[C@@H]1C[C@H](CO)N1c1nc(OC[C@@]23CCCN2C[C@H](F)C3)nc2c1CO[C@@]1(CC[C@H](C)c3ccc(N)c(C#N)c31)C2	InChI=1S/C31H39FN6O3/c1-18-6-8-31(27-22(18)4-5-25(34)23(27)13-33)12-26-24(16-41-31)28(38-19(2)10-21(38)15-39)36-29(35-26)40-17-30-7-3-9-37(30)14-20(32)11-30/h4-5,18-21,39H,3,6-12,14-17,34H2,1-2H3	CQAVGXILPOPRIZ-UHFFFAOYSA-N	436993	(1S,4S)-7-Amino-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-4'-((2R,4R)-2-(hydroxymethyl)-4-methylazetidin-1-yl)-4-methyl-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidine]-8-carbonitrile ::US20260022132, Compound 640a	GTPase KRas [G12V]	Homo sapiens			 0.091						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436993	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436993&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493805	439658622							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212283	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4[C@@H](CO)C[C@@H]4C)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C31H39FN6O3/c1-18-6-8-31(27-22(18)4-5-25(34)23(27)13-33)12-26-24(16-41-31)28(38-19(2)10-21(38)15-39)36-29(35-26)40-17-30-7-3-9-37(30)14-20(32)11-30/h4-5,18-21,39H,3,6-12,14-17,34H2,1-2H3	CQAVGXILPOPRIZ-UHFFFAOYSA-N	437155	US20260022132, Compound 640b	GTPase KRas [G12V]	Homo sapiens			 0.240						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437155	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437155&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134494099	439658784							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212284	C[C@H]1CCC2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCCn5nc(C(=O)N(C)C)c(Cl)c5C4)c3CO2)c2c1cc(F)c(N)c2C#N	InChI=1S/C36H42ClF2N9O3/c1-20-6-8-36(28-22(20)12-25(39)30(41)23(28)15-40)14-26-24(18-51-36)32(43-34(42-26)50-19-35-7-4-10-47(35)16-21(38)13-35)46-9-5-11-48-27(17-46)29(37)31(44-48)33(49)45(2)3/h12,20-21H,4-11,13-14,16-19,41H2,1-3H3	OMOWVWMFRSPMOZ-UHFFFAOYSA-N	436994	US20260022132, Compound 641a	GTPase KRas [G12V]	Homo sapiens			 0.490						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436994	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436994&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493874	439658623							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212285	N#CC[C@H]1CN(c2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc3c(F)c(-c4c(C)ccc5[nH]ncc45)ccc23)CCN1C(=O)/C(F)=C/c1nccs1	InChI=1S/C36H34F3N9O2S/c1-21-3-6-28-26(17-42-45-28)30(21)24-4-5-25-32(31(24)39)43-35(50-20-36-8-2-11-47(36)18-22(37)16-36)44-33(25)46-12-13-48(23(19-46)7-9-40)34(49)27(38)15-29-41-10-14-51-29/h3-6,10,14-15,17,22-23H,2,7-8,11-13,16,18-20H2,1H3,(H,42,45)	QHCHTMRGWLBBAS-UHFFFAOYSA-N	436995	US20260022132, Compound 641b	GTPase KRas [G12V]	Homo sapiens			 0.260						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436995	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436995&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493783	439658624							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212286	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCCn5nc(C(=O)N(C)C)c(Cl)c5C4)c3CO2)c2c1cc(F)c(N)c2C#N	InChI=1S/C36H42ClF2N9O3/c1-20-6-8-36(28-22(20)12-25(39)30(41)23(28)15-40)14-26-24(18-51-36)32(43-34(42-26)50-19-35-7-4-10-47(35)16-21(38)13-35)46-9-5-11-48-27(17-46)29(37)31(44-48)33(49)45(2)3/h12,20-21H,4-11,13-14,16-19,41H2,1-3H3	OMOWVWMFRSPMOZ-UHFFFAOYSA-N	436996	US20260022132, Compound 641c	GTPase KRas [G12V]	Homo sapiens			 9.00						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436996	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436996&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493627	439658625							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212287	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCCC45CCOC5)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C33H41FN6O3/c1-21-6-9-33(28-23(21)4-5-26(36)24(28)16-35)15-27-25(18-43-33)29(40-12-3-7-31(40)10-13-41-19-31)38-30(37-27)42-20-32-8-2-11-39(32)17-22(34)14-32/h4-5,21-22H,2-3,6-15,17-20,36H2,1H3	SBECINMRVIKQRS-UHFFFAOYSA-N	436997	US20260022132, Compound 642a	GTPase KRas [G12V]	Homo sapiens			 1.000						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436997	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436997&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490043	439658626							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212288	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCC[C@@H]4C)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C31H39FN6O2/c1-19-8-10-31(27-22(19)6-7-25(34)23(27)15-33)14-26-24(17-40-31)28(38-12-3-5-20(38)2)36-29(35-26)39-18-30-9-4-11-37(30)16-21(32)13-30/h6-7,19-21H,3-5,8-14,16-18,34H2,1-2H3	IHFQUIFNKJDARV-UHFFFAOYSA-N	436998	US20260022132, Compound 643a	GTPase KRas [G12V]	Homo sapiens			 3.30						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436998	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436998&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493931	439658627							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212289	C[C@@H]1CCCN1c1nc(OC[C@@]23CCCN2C[C@H](F)C3)nc2c1CO[C@@]1(CC[C@H](C)c3ccc(N)c(C#N)c31)C2	InChI=1S/C31H39FN6O2/c1-19-8-10-31(27-22(19)6-7-25(34)23(27)15-33)14-26-24(17-40-31)28(38-12-3-5-20(38)2)36-29(35-26)39-18-30-9-4-11-37(30)16-21(32)13-30/h6-7,19-21H,3-5,8-14,16-18,34H2,1-2H3	IHFQUIFNKJDARV-UHFFFAOYSA-N	436999	US20260022132, Compound 643b	GTPase KRas [G12V]	Homo sapiens			 8.40						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=436999	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=436999&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134494066	439658628							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212290	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCC5(COC5)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H39FN6O3/c1-20-5-7-32(27-22(20)3-4-25(35)23(27)13-34)12-26-24(15-42-32)28(38-10-8-30(16-38)17-40-18-30)37-29(36-26)41-19-31-6-2-9-39(31)14-21(33)11-31/h3-4,20-21H,2,5-12,14-19,35H2,1H3	QARPBRXFHMNRJT-UHFFFAOYSA-N	437000	US20260022132, Compound 644a	GTPase KRas [G12V]	Homo sapiens			 72.0						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437000	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437000&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493628	439658629							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212291	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCC[C@H]4C#N)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C31H36FN7O2/c1-19-7-9-31(27-22(19)5-6-25(35)23(27)15-34)13-26-24(17-41-31)28(39-11-2-4-21(39)14-33)37-29(36-26)40-18-30-8-3-10-38(30)16-20(32)12-30/h5-6,19-21H,2-4,7-13,16-18,35H2,1H3	XDEDHBFKPBMMLQ-UHFFFAOYSA-N	437001	US20260022132, Compound 645a	GTPase KRas [G12V]	Homo sapiens			 16.0						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437001	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437001&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134494069	439658630							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212292	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCC[C@@H]4C#N)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C31H36FN7O2/c1-19-7-9-31(27-22(19)5-6-25(35)23(27)15-34)13-26-24(17-41-31)28(39-11-2-4-21(39)14-33)37-29(36-26)40-18-30-8-3-10-38(30)16-20(32)12-30/h5-6,19-21H,2-4,7-13,16-18,35H2,1H3	XDEDHBFKPBMMLQ-UHFFFAOYSA-N	437002	US20260022132, Compound 645b	GTPase KRas [G12V]	Homo sapiens			 7.90						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437002	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437002&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493606	439658631							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212293	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4C[C@H]5COC[C@H]5C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H39FN6O3/c1-19-5-7-32(28-23(19)3-4-26(35)24(28)11-34)10-27-25(17-42-32)29(38-12-20-15-40-16-21(20)13-38)37-30(36-27)41-18-31-6-2-8-39(31)14-22(33)9-31/h3-4,19-22H,2,5-10,12-18,35H2,1H3	VRUYRSYRCGTULZ-UHFFFAOYSA-N	437003	US20260022132, Compound 646a	GTPase KRas [G12V]	Homo sapiens			 55.0						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437003	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437003&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490044	439658632							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212294	C[C@H]7CC[C@]5(Cc4nc(OC[C@@]12CCCN1C[C@H](F)C2)nc(N3CC[C@@H](O)C3)c4CO5)c6c(C#N)c(N)ccc67	InChI=1S/C31H38FN5O3/c1-3-22-25(33)6-5-23-19(2)7-10-31(27(22)23)14-26-24(17-40-31)28(36-12-8-21(38)16-36)35-29(34-26)39-18-30-9-4-11-37(30)15-20(32)13-30/h1,5-6,19-21,38H,4,7-18,33H2,2H3	YEHMEZYZYYIVHP-UHFFFAOYSA-N	437004	US20260022132, Compound 647a	GTPase KRas [G12V]	Homo sapiens			 26.0						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437004	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437004&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490045	439658633							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212295	C[C@H]7CC[C@]5(Cc4nc(OC[C@@]12CCCN1C[C@H](F)C2)nc(N3CC[C@H](O)C3)c4CO5)c6c(C#N)c(N)ccc67	InChI=1S/C31H38FN5O3/c1-3-22-25(33)6-5-23-19(2)7-10-31(27(22)23)14-26-24(17-40-31)28(36-12-8-21(38)16-36)35-29(34-26)39-18-30-9-4-11-37(30)15-20(32)13-30/h1,5-6,19-21,38H,4,7-18,33H2,2H3	YEHMEZYZYYIVHP-UHFFFAOYSA-N	437005	US20260022132, Compound 647b	GTPase KRas [G12V]	Homo sapiens			 17.0						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437005	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437005&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490048	439658634							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212296	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC[C@@H](F)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C30H36F2N6O2/c1-18-5-8-30(26-21(18)3-4-24(34)22(26)13-33)12-25-23(16-40-30)27(37-10-6-19(31)14-37)36-28(35-25)39-17-29-7-2-9-38(29)15-20(32)11-29/h3-4,18-20H,2,5-12,14-17,34H2,1H3	FIFKBNCMFNVVJI-UHFFFAOYSA-N	437006	US20260022132, Compound 648a	GTPase KRas [G12V]	Homo sapiens			 18.0						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437006	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437006&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490046	439658635							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212297	C[C@H]7CC[C@]5(Cc4nc(OC[C@@]12CCCN1C[C@H](F)C2)nc(N3CC[C@H](F)C3)c4CO5)c6c(C#N)c(N)ccc67	InChI=1S/C31H37F2N5O2/c1-3-22-25(34)6-5-23-19(2)7-10-31(27(22)23)14-26-24(17-40-31)28(37-12-8-20(32)15-37)36-29(35-26)39-18-30-9-4-11-38(30)16-21(33)13-30/h1,5-6,19-21H,4,7-18,34H2,2H3	GUHGAJSCTDCYBF-UHFFFAOYSA-N	437007	US20260022132, Compound 648b	GTPase KRas [G12V]	Homo sapiens			 19.0						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437007	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437007&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490047	439658636							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212298	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC[C@@H](CO)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C31H39FN6O3/c1-19-5-8-31(27-22(19)3-4-25(34)23(27)13-33)12-26-24(17-41-31)28(37-10-6-20(14-37)16-39)36-29(35-26)40-18-30-7-2-9-38(30)15-21(32)11-30/h3-4,19-21,39H,2,5-12,14-18,34H2,1H3	HSJSXJXGHTYHOS-UHFFFAOYSA-N	437008	US20260022132, Compound 649a	GTPase KRas [G12V]	Homo sapiens			 25.0						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437008	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437008&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490049	439658637							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212299	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC[C@H](CO)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C31H39FN6O3/c1-19-5-8-31(27-22(19)3-4-25(34)23(27)13-33)12-26-24(17-41-31)28(37-10-6-20(14-37)16-39)36-29(35-26)40-18-30-7-2-9-38(30)15-21(32)11-30/h3-4,19-21,39H,2,5-12,14-18,34H2,1H3	HSJSXJXGHTYHOS-UHFFFAOYSA-N	437009	US20260022132, Compound 649b	GTPase KRas [G12V]	Homo sapiens			 21.0						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437009	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437009&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490050	439658638							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212300	N#C[C@@H]1C[C@@H](O)CN1c1nc(OC[C@@]23CCCN2C[C@H](F)C3)nc2c1CO[C@@]1(CC[C@H](C)c3ccc(N)c(C#N)c31)C2	InChI=1S/C31H36FN7O3/c1-18-5-7-31(27-22(18)3-4-25(35)23(27)13-34)11-26-24(16-42-31)28(39-15-21(40)9-20(39)12-33)37-29(36-26)41-17-30-6-2-8-38(30)14-19(32)10-30/h3-4,18-21,40H,2,5-11,14-17,35H2,1H3	COVJVOAJFJQESS-UHFFFAOYSA-N	437010	US20260022132, Compound 650a	GTPase KRas [G12V]	Homo sapiens			 20.0						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437010	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437010&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490051	439658639							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212301	N#C[C@@H]1C[C@H](O)CN1c1nc(OC[C@@]23CCCN2C[C@H](F)C3)nc2c1CO[C@@]1(CC[C@H](C)c3ccc(N)c(C#N)c31)C2	InChI=1S/C31H36FN7O3/c1-18-5-7-31(27-22(18)3-4-25(35)23(27)13-34)11-26-24(16-42-31)28(39-15-21(40)9-20(39)12-33)37-29(36-26)41-17-30-6-2-8-38(30)14-19(32)10-30/h3-4,18-21,40H,2,5-11,14-17,35H2,1H3	COVJVOAJFJQESS-UHFFFAOYSA-N	437011	US20260022132, Compound 650b	GTPase KRas [G12V]	Homo sapiens			 16.0						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437011	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437011&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490052	439658640							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212302	N#C[C@H]1C[C@H](O)CN1c1nc(OC[C@@]23CCCN2C[C@H](F)C3)nc2c1CO[C@@]1(CC[C@H](C)c3ccc(N)c(C#N)c31)C2	InChI=1S/C31H36FN7O3/c1-18-5-7-31(27-22(18)3-4-25(35)23(27)13-34)11-26-24(16-42-31)28(39-15-21(40)9-20(39)12-33)37-29(36-26)41-17-30-6-2-8-38(30)14-19(32)10-30/h3-4,18-21,40H,2,5-11,14-17,35H2,1H3	COVJVOAJFJQESS-UHFFFAOYSA-N	437012	US20260022132, Compound 650c	GTPase KRas [G12V]	Homo sapiens			 120						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437012	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437012&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490053	439658641							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212303	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4C[C@H](O)C[C@@H]4C#N)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C31H36FN7O3/c1-18-5-7-31(27-22(18)3-4-25(35)23(27)13-34)11-26-24(16-42-31)28(39-15-21(40)9-20(39)12-33)37-29(36-26)41-17-30-6-2-8-38(30)14-19(32)10-30/h3-4,18-21,40H,2,5-11,14-17,35H2,1H3	COVJVOAJFJQESS-UHFFFAOYSA-N	437013	US20260022132, Compound 650d	GTPase KRas [G12V]	Homo sapiens			 40.0						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437013	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437013&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490054	439658642							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212304	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4C[C@H](O)C[C@H]4C(N)=O)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C31H38FN7O4/c1-17-5-7-31(26-20(17)3-4-23(34)21(26)12-33)11-24-22(15-43-31)28(39-14-19(40)9-25(39)27(35)41)37-29(36-24)42-16-30-6-2-8-38(30)13-18(32)10-30/h3-4,17-19,25,40H,2,5-11,13-16,34H2,1H3,(H2,35,41)	XRWAVKHHFUDCKC-UHFFFAOYSA-N	437014	US20260022132, Compound 651a	GTPase KRas [G12V]	Homo sapiens			 34.0						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437014	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437014&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490055	439658643							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212305	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4C[C@@H](O)C[C@H]4C(N)=O)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C31H38FN7O4/c1-17-5-7-31(26-20(17)3-4-23(34)21(26)12-33)11-24-22(15-43-31)28(39-14-19(40)9-25(39)27(35)41)37-29(36-24)42-16-30-6-2-8-38(30)13-18(32)10-30/h3-4,17-19,25,40H,2,5-11,13-16,34H2,1H3,(H2,35,41)	XRWAVKHHFUDCKC-UHFFFAOYSA-N	437015	US20260022132, Compound 651b	GTPase KRas [G12V]	Homo sapiens			 56.0						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437015	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437015&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490056	439658644							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212306	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCC5(CCO5)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H39FN6O3/c1-20-5-7-32(27-22(20)3-4-25(35)23(27)15-34)14-26-24(17-42-32)28(38-11-8-31(18-38)9-12-41-31)37-29(36-26)40-19-30-6-2-10-39(30)16-21(33)13-30/h3-4,20-21H,2,5-14,16-19,35H2,1H3	RTKFNUOAOVWERI-UHFFFAOYSA-N	437016	US20260022132, Compound 652a	GTPase KRas [G12V]	Homo sapiens			 320						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437016	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437016&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490057	439658645							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212307	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC[C@@]5(CCO5)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H39FN6O3/c1-20-5-7-32(27-22(20)3-4-25(35)23(27)15-34)14-26-24(17-42-32)28(38-11-8-31(18-38)9-12-41-31)37-29(36-26)40-19-30-6-2-10-39(30)16-21(33)13-30/h3-4,20-21H,2,5-14,16-19,35H2,1H3	RTKFNUOAOVWERI-UHFFFAOYSA-N	437017	US20260022132, Compound 652b	GTPase KRas [G12V]	Homo sapiens			>500						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437017	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437017&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490058	439658646							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212308	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC[C@]5(CCO5)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H39FN6O3/c1-20-5-7-32(27-22(20)3-4-25(35)23(27)15-34)14-26-24(17-42-32)28(38-11-8-31(18-38)9-12-41-31)37-29(36-26)40-19-30-6-2-10-39(30)16-21(33)13-30/h3-4,20-21H,2,5-14,16-19,35H2,1H3	RTKFNUOAOVWERI-UHFFFAOYSA-N	437018	US20260022132, Compound 652c	GTPase KRas [G12V]	Homo sapiens			 210						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437018	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437018&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490059	439658647							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212309	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4C[C@H](C)[C@@H]4CO)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C31H39FN6O3/c1-18-6-8-31(27-21(18)4-5-24(34)22(27)12-33)11-25-23(16-41-31)28(38-13-19(2)26(38)15-39)36-29(35-25)40-17-30-7-3-9-37(30)14-20(32)10-30/h4-5,18-20,26,39H,3,6-11,13-17,34H2,1-2H3	ZBBUKADONAIUOW-UHFFFAOYSA-N	437019	US20260022132, Compound 653a	GTPase KRas [G12V]	Homo sapiens			 9.20						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437019	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437019&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490062	439658648							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212310	C[C@@H]1CN(c2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc3c2CO[C@@]2(CC[C@H](C)c4ccc(N)c(C#N)c42)C3)[C@H]1CO	InChI=1S/C31H39FN6O3/c1-18-6-8-31(27-21(18)4-5-24(34)22(27)12-33)11-25-23(16-41-31)28(38-13-19(2)26(38)15-39)36-29(35-25)40-17-30-7-3-9-37(30)14-20(32)10-30/h4-5,18-20,26,39H,3,6-11,13-17,34H2,1-2H3	ZBBUKADONAIUOW-UHFFFAOYSA-N	437020	US20260022132, Compound 653b	GTPase KRas [G12V]	Homo sapiens			 1.10						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437020	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437020&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490063	439658649							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212311	CO[C@H]1CN2CCC[C@@]2(COc2nc3c(c(N4CC[C@@]45CCOC5)n2)CO[C@@]2(CC[C@H](C)c4ccc(N)c(C#N)c42)C3)C1	InChI=1S/C33H42N6O4/c1-21-6-8-33(28-23(21)4-5-26(35)24(28)16-34)15-27-25(18-43-33)29(39-12-9-31(39)10-13-41-19-31)37-30(36-27)42-20-32-7-3-11-38(32)17-22(14-32)40-2/h4-5,21-22H,3,6-15,17-20,35H2,1-2H3	DWLNIOPNCRBZDB-UHFFFAOYSA-N	437021	US20260022132, Compound 654a	GTPase KRas [G12V]	Homo sapiens			 2.50						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437021	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437021&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490060	439658650							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212312	CO[C@@H]1CN2CCC[C@]2(COc2nc3c(c(N4CC[C@@]45CCOC5)n2)CO[C@@]2(CC[C@H](C)c4ccc(N)c(C#N)c42)C3)C1	InChI=1S/C33H42N6O4/c1-21-6-8-33(28-23(21)4-5-26(35)24(28)16-34)15-27-25(18-43-33)29(39-12-9-31(39)10-13-41-19-31)37-30(36-27)42-20-32-7-3-11-38(32)17-22(14-32)40-2/h4-5,21-22H,3,6-15,17-20,35H2,1-2H3	DWLNIOPNCRBZDB-UHFFFAOYSA-N	437022	US20260022132, Compound 654b	GTPase KRas [G12V]	Homo sapiens			 8.70						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437022	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437022&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490061	439658651							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212313	CO[C@@H]1CN2CCC[C@]2(COc2nc3c(c(N4CC[C@]45CCOC5)n2)CO[C@@]2(CC[C@H](C)c4ccc(N)c(C#N)c42)C3)C1	InChI=1S/C33H42N6O4/c1-21-6-8-33(28-23(21)4-5-26(35)24(28)16-34)15-27-25(18-43-33)29(39-12-9-31(39)10-13-41-19-31)37-30(36-27)42-20-32-7-3-11-38(32)17-22(14-32)40-2/h4-5,21-22H,3,6-15,17-20,35H2,1-2H3	DWLNIOPNCRBZDB-UHFFFAOYSA-N	437023	US20260022132, Compound 654c	GTPase KRas [G12V]	Homo sapiens			 0.830						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437023	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437023&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490064	439658652							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212314	CO[C@H]1CN2CCC[C@@]2(COc2nc3c(c(N4CC[C@]45CCOC5)n2)CO[C@@]2(CC[C@H](C)c4ccc(N)c(C#N)c42)C3)C1	InChI=1S/C33H42N6O4/c1-21-6-8-33(28-23(21)4-5-26(35)24(28)16-34)15-27-25(18-43-33)29(39-12-9-31(39)10-13-41-19-31)37-30(36-27)42-20-32-7-3-11-38(32)17-22(14-32)40-2/h4-5,21-22H,3,6-15,17-20,35H2,1-2H3	DWLNIOPNCRBZDB-UHFFFAOYSA-N	437024	US20260022132, Compound 654d	GTPase KRas [G12V]	Homo sapiens			 0.180						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437024	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437024&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490065	439658653							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212315	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4[C@@H](C)CC[C@@H]4C)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H41FN6O2/c1-19-9-11-32(28-23(19)7-8-26(35)24(28)15-34)14-27-25(17-41-32)29(39-20(2)5-6-21(39)3)37-30(36-27)40-18-31-10-4-12-38(31)16-22(33)13-31/h7-8,19-22H,4-6,9-14,16-18,35H2,1-3H3	IJAQFMFQRQRMQA-UHFFFAOYSA-N	437025	US20260022132, Compound 655a	GTPase KRas [G12V]	Homo sapiens			 3.40						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437025	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437025&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490066	439658654							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212316	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCC[C@H]4C(N)=O)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C31H38FN7O3/c1-18-7-9-31(26-20(18)5-6-23(34)21(26)14-33)13-24-22(16-42-31)28(39-11-2-4-25(39)27(35)40)37-29(36-24)41-17-30-8-3-10-38(30)15-19(32)12-30/h5-6,18-19,25H,2-4,7-13,15-17,34H2,1H3,(H2,35,40)	GUGFKPRHXBRWJX-UHFFFAOYSA-N	437026	US20260022132, Compound 656a	GTPase KRas [G12V]	Homo sapiens			 6.30						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437026	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437026&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490070	439658655							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212317	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4C(=O)CC[C@@H]4CN)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C31H38FN7O3/c1-18-7-9-31(27-21(18)4-5-24(35)22(27)14-34)12-25-23(16-42-31)28(39-20(13-33)3-6-26(39)40)37-29(36-25)41-17-30-8-2-10-38(30)15-19(32)11-30/h4-5,18-20H,2-3,6-13,15-17,33,35H2,1H3	CUDSWDHLYNVFJI-UHFFFAOYSA-N	437027	US20260022132, Compound 657a	GTPase KRas [G12V]	Homo sapiens			 210						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437027	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437027&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490067	439658656							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212318	CC1CN(c2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc3c2CO[C@@]2(CC[C@H](C)c4ccc(N)c(C#N)c42)C3)C1	InChI=1S/C30H37FN6O2/c1-18-13-36(14-18)27-23-16-39-30(8-6-19(2)21-4-5-24(33)22(12-32)26(21)30)11-25(23)34-28(35-27)38-17-29-7-3-9-37(29)15-20(31)10-29/h4-5,18-20H,3,6-11,13-17,33H2,1-2H3	WFWLDYHYZJKJIZ-UHFFFAOYSA-N	437028	US20260022132, Compound 658a	GTPase KRas [G12V]	Homo sapiens			 34.0						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437028	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437028&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493826	439658657							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212319	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC(C)(O)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C30H37FN6O3/c1-18-6-8-30(25-20(18)4-5-23(33)21(25)12-32)11-24-22(14-40-30)26(36-15-28(2,38)16-36)35-27(34-24)39-17-29-7-3-9-37(29)13-19(31)10-29/h4-5,18-19,38H,3,6-11,13-17,33H2,1-2H3	KUGIYRGVFHLKIH-UHFFFAOYSA-N	437029	US20260022132, Compound 659a	GTPase KRas [G12V]	Homo sapiens			 45.0						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437029	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437029&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490069	439658658							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212320	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC[C@@H]5C[C@@H]54)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C31H37FN6O2/c1-18-5-8-31(27-21(18)3-4-24(34)22(27)14-33)13-25-23(16-40-31)28(38-10-6-19-11-26(19)38)36-29(35-25)39-17-30-7-2-9-37(30)15-20(32)12-30/h3-4,18-20,26H,2,5-13,15-17,34H2,1H3	IQYKUQMIVYPPOQ-UHFFFAOYSA-N	437030	US20260022132, Compound 660a	GTPase KRas [G12V]	Homo sapiens			 5.10						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437030	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437030&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490071	439658659							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212321	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC[C@H]5C[C@H]54)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C31H37FN6O2/c1-18-5-8-31(27-21(18)3-4-24(34)22(27)14-33)13-25-23(16-40-31)28(38-10-6-19-11-26(19)38)36-29(35-25)39-17-30-7-2-9-37(30)15-20(32)12-30/h3-4,18-20,26H,2,5-13,15-17,34H2,1H3	IQYKUQMIVYPPOQ-UHFFFAOYSA-N	437031	US20260022132, Compound 660b	GTPase KRas [G12V]	Homo sapiens			 5.30						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437031	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437031&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490072	439658660							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212322	N#C[C@H]1CCN(c2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc3c2CO[C@@]2(CC[C@H](C)c4ccc(N)c(C#N)c42)C3)C1	InChI=1S/C31H36FN7O2/c1-19-5-8-31(27-22(19)3-4-25(35)23(27)14-34)12-26-24(17-41-31)28(38-10-6-20(13-33)15-38)37-29(36-26)40-18-30-7-2-9-39(30)16-21(32)11-30/h3-4,19-21H,2,5-12,15-18,35H2,1H3	MCVZLKKAOQTZQY-UHFFFAOYSA-N	437032	US20260022132, Compound 661a	GTPase KRas [G12V]	Homo sapiens			 35.0						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437032	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437032&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490073	439658661							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212323	N#C[C@@H]1CCN(c2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc3c2CO[C@@]2(CC[C@H](C)c4ccc(N)c(C#N)c42)C3)C1	InChI=1S/C31H36FN7O2/c1-19-5-8-31(27-22(19)3-4-25(35)23(27)14-34)12-26-24(17-41-31)28(38-10-6-20(13-33)15-38)37-29(36-26)40-18-30-7-2-9-39(30)16-21(32)11-30/h3-4,19-21H,2,5-12,15-18,35H2,1H3	MCVZLKKAOQTZQY-UHFFFAOYSA-N	437033	US20260022132, Compound 661b	GTPase KRas [G12V]	Homo sapiens			 13.0						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437033	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437033&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490074	439658662							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212324	CO[C@@H]1CN2CCC[C@]2(COc2nc3c(c(N4CC[C@]45CCCOC5)n2)CO[C@@]2(CC[C@H](C)c4ccc(N)c(C#N)c42)C3)C1	InChI=1S/C34H44N6O4/c1-22-7-10-34(29-24(22)5-6-27(36)25(29)17-35)16-28-26(19-44-34)30(40-13-11-32(40)9-4-14-42-20-32)38-31(37-28)43-21-33-8-3-12-39(33)18-23(15-33)41-2/h5-6,22-23H,3-4,7-16,18-21,36H2,1-2H3	RNVKWRBVXPJAJZ-UHFFFAOYSA-N	437034	US20260022132, Compound 662a	GTPase KRas [G12V]	Homo sapiens			 1.10						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437034	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437034&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490075	439658663							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212325	CO[C@H]1CN2CCC[C@@]2(COc2nc3c(c(N4CC[C@]45CCCOC5)n2)CO[C@@]2(CC[C@H](C)c4ccc(N)c(C#N)c42)C3)C1	InChI=1S/C34H44N6O4/c1-22-7-10-34(29-24(22)5-6-27(36)25(29)17-35)16-28-26(19-44-34)30(40-13-11-32(40)9-4-14-42-20-32)38-31(37-28)43-21-33-8-3-12-39(33)18-23(15-33)41-2/h5-6,22-23H,3-4,7-16,18-21,36H2,1-2H3	RNVKWRBVXPJAJZ-UHFFFAOYSA-N	437035	US20260022132, Compound 662b	GTPase KRas [G12V]	Homo sapiens			 0.190						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437035	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437035&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490076	439658664							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212326	CO[C@@H]1CN2CCC[C@]2(COc2nc3c(c(N4CC[C@@]45CCCOC5)n2)CO[C@@]2(CC[C@H](C)c4ccc(N)c(C#N)c42)C3)C1	InChI=1S/C34H44N6O4/c1-22-7-10-34(29-24(22)5-6-27(36)25(29)17-35)16-28-26(19-44-34)30(40-13-11-32(40)9-4-14-42-20-32)38-31(37-28)43-21-33-8-3-12-39(33)18-23(15-33)41-2/h5-6,22-23H,3-4,7-16,18-21,36H2,1-2H3	RNVKWRBVXPJAJZ-UHFFFAOYSA-N	437036	US20260022132, Compound 662c	GTPase KRas [G12V]	Homo sapiens			 28.0						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437036	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437036&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490077	439658665							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212327	CO[C@H]1CN2CCC[C@@]2(COc2nc3c(c(N4CC[C@@]45CCCOC5)n2)CO[C@@]2(CC[C@H](C)c4ccc(N)c(C#N)c42)C3)C1	InChI=1S/C34H44N6O4/c1-22-7-10-34(29-24(22)5-6-27(36)25(29)17-35)16-28-26(19-44-34)30(40-13-11-32(40)9-4-14-42-20-32)38-31(37-28)43-21-33-8-3-12-39(33)18-23(15-33)41-2/h5-6,22-23H,3-4,7-16,18-21,36H2,1-2H3	RNVKWRBVXPJAJZ-UHFFFAOYSA-N	437037	US20260022132, Compound 662d	GTPase KRas [G12V]	Homo sapiens			 9.00						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437037	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437037&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493853	439658666							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212328	N#Cc1c(N)ccc2c1[C@]1(CCC2)Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc([C@H]3CCOC3)c2CO1	InChI=1S/C29H34FN5O3/c30-20-11-28(7-2-9-35(28)14-20)17-37-27-33-24-12-29(38-16-22(24)26(34-27)19-6-10-36-15-19)8-1-3-18-4-5-23(32)21(13-31)25(18)29/h4-5,19-20H,1-3,6-12,14-17,32H2	GNLMLIKHAKZLAN-UHFFFAOYSA-N	437038	US20260022132, Compound 663a	GTPase KRas [G12V]	Homo sapiens			 13.0						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437038	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437038&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490079	439658667							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212329	N#Cc1c(N)ccc2c1[C@]1(CCC2)Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc([C@H]3CCOC3)c2CO1	InChI=1S/C29H34FN5O3/c30-20-11-28(7-2-9-35(28)14-20)17-37-27-33-24-12-29(38-16-22(24)26(34-27)19-6-10-36-15-19)8-1-3-18-4-5-23(32)21(13-31)25(18)29/h4-5,19-20H,1-3,6-12,14-17,32H2	GNLMLIKHAKZLAN-UHFFFAOYSA-N	437038	US20260022132, Compound 663a	GTPase KRas [G12V]	Homo sapiens			 130						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437038	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437038&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490079	439658667							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212330	N#Cc1c(N)ccc2c1[C@]1(CCC2)Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc([C@@H]3CCOC3)c2CO1	InChI=1S/C29H34FN5O3/c30-20-11-28(7-2-9-35(28)14-20)17-37-27-33-24-12-29(38-16-22(24)26(34-27)19-6-10-36-15-19)8-1-3-18-4-5-23(32)21(13-31)25(18)29/h4-5,19-20H,1-3,6-12,14-17,32H2	GNLMLIKHAKZLAN-UHFFFAOYSA-N	437039	US20260022132, Compound 663b	GTPase KRas [G12V]	Homo sapiens			 43.0						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437039	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437039&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490080	439658668							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212331	N#Cc1c(N)ccc2c1[C@]1(CCC2)Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc([C@@H]3CCOC3)c2CO1	InChI=1S/C29H34FN5O3/c30-20-11-28(7-2-9-35(28)14-20)17-37-27-33-24-12-29(38-16-22(24)26(34-27)19-6-10-36-15-19)8-1-3-18-4-5-23(32)21(13-31)25(18)29/h4-5,19-20H,1-3,6-12,14-17,32H2	GNLMLIKHAKZLAN-UHFFFAOYSA-N	437039	US20260022132, Compound 663b	GTPase KRas [G12V]	Homo sapiens			 410						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437039	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437039&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490080	439658668							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212332	N#Cc1c(N)ccc2c1[C@]1(CCC2)Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc([C@H]3CCCO3)c2CO1	InChI=1S/C29H34FN5O3/c30-19-12-28(8-3-10-35(28)15-19)17-37-27-33-23-13-29(38-16-21(23)26(34-27)24-5-2-11-36-24)9-1-4-18-6-7-22(32)20(14-31)25(18)29/h6-7,19,24H,1-5,8-13,15-17,32H2	VVULFPFQDPTCQF-UHFFFAOYSA-N	437040	US20260022132, Compound 664a	GTPase KRas [G12V]	Homo sapiens			 4.00						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437040	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437040&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490081	439658669							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212333	N#Cc1c(N)ccc2c1[C@]1(CCC2)Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc([C@H]3CCCO3)c2CO1	InChI=1S/C29H34FN5O3/c30-19-12-28(8-3-10-35(28)15-19)17-37-27-33-23-13-29(38-16-21(23)26(34-27)24-5-2-11-36-24)9-1-4-18-6-7-22(32)20(14-31)25(18)29/h6-7,19,24H,1-5,8-13,15-17,32H2	VVULFPFQDPTCQF-UHFFFAOYSA-N	437040	US20260022132, Compound 664a	GTPase KRas [G12V]	Homo sapiens			 44.0						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437040	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437040&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490081	439658669							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212334	N#Cc1c(N)ccc2c1[C@]1(CCC2)Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc([C@@H]3CCCO3)c2CO1	InChI=1S/C29H34FN5O3/c30-19-12-28(8-3-10-35(28)15-19)17-37-27-33-23-13-29(38-16-21(23)26(34-27)24-5-2-11-36-24)9-1-4-18-6-7-22(32)20(14-31)25(18)29/h6-7,19,24H,1-5,8-13,15-17,32H2	VVULFPFQDPTCQF-UHFFFAOYSA-N	437041	US20260022132, Compound 664b	GTPase KRas [G12V]	Homo sapiens			 42.0						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437041	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437041&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490082	439658670							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212335	N#Cc1c(N)ccc2c1[C@]1(CCC2)Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc([C@@H]3CCCO3)c2CO1	InChI=1S/C29H34FN5O3/c30-19-12-28(8-3-10-35(28)15-19)17-37-27-33-23-13-29(38-16-21(23)26(34-27)24-5-2-11-36-24)9-1-4-18-6-7-22(32)20(14-31)25(18)29/h6-7,19,24H,1-5,8-13,15-17,32H2	VVULFPFQDPTCQF-UHFFFAOYSA-N	437041	US20260022132, Compound 664b	GTPase KRas [G12V]	Homo sapiens			 270						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437041	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437041&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490082	439658670							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212336	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc([C@H]4CCCO4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C30H36FN5O3/c1-18-7-9-30(26-20(18)5-6-23(33)21(26)14-32)13-24-22(16-39-30)27(25-4-2-11-37-25)35-28(34-24)38-17-29-8-3-10-36(29)15-19(31)12-29/h5-6,18-19,25H,2-4,7-13,15-17,33H2,1H3	ISXVQBCKBHYBLS-UHFFFAOYSA-N	437042	US20260022132, Compound 665a	GTPase KRas [G12V]	Homo sapiens			 0.180						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437042	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437042&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490083	439658671							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212337	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc([C@H]4CCCO4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C30H36FN5O3/c1-18-7-9-30(26-20(18)5-6-23(33)21(26)14-32)13-24-22(16-39-30)27(25-4-2-11-37-25)35-28(34-24)38-17-29-8-3-10-36(29)15-19(31)12-29/h5-6,18-19,25H,2-4,7-13,15-17,33H2,1H3	ISXVQBCKBHYBLS-UHFFFAOYSA-N	437042	US20260022132, Compound 665a	GTPase KRas [G12V]	Homo sapiens			 2.10						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437042	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437042&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490083	439658671							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212338	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc([C@@H]4CCCO4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C30H36FN5O3/c1-18-7-9-30(26-20(18)5-6-23(33)21(26)14-32)13-24-22(16-39-30)27(25-4-2-11-37-25)35-28(34-24)38-17-29-8-3-10-36(29)15-19(31)12-29/h5-6,18-19,25H,2-4,7-13,15-17,33H2,1H3	ISXVQBCKBHYBLS-UHFFFAOYSA-N	437043	US20260022132, Compound 665b	GTPase KRas [G12V]	Homo sapiens			 3.80						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437043	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437043&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490084	439658672							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212339	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc([C@@H]4CCCO4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C30H36FN5O3/c1-18-7-9-30(26-20(18)5-6-23(33)21(26)14-32)13-24-22(16-39-30)27(25-4-2-11-37-25)35-28(34-24)38-17-29-8-3-10-36(29)15-19(31)12-29/h5-6,18-19,25H,2-4,7-13,15-17,33H2,1H3	ISXVQBCKBHYBLS-UHFFFAOYSA-N	437043	US20260022132, Compound 665b	GTPase KRas [G12V]	Homo sapiens			 32.0						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437043	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437043&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490084	439658672							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212340	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4CC(F)(F)C5)nc(N4CCC45COC5)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C31H36F2N6O3/c1-19-5-7-30(25-20(19)3-4-23(35)21(25)12-34)11-24-22(13-42-30)26(39-10-8-29(39)16-40-17-29)37-27(36-24)41-18-28-6-2-9-38(28)15-31(32,33)14-28/h3-4,19H,2,5-11,13-18,35H2,1H3	XDFIROPWACSWKD-UHFFFAOYSA-N	437044	US20260022132, Compound 666a	GTPase KRas [G12V]	Homo sapiens			 10.00						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437044	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437044&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490085	439658673							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212341	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC[C@@](C)(O)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C31H39FN6O3/c1-19-6-8-31(26-21(19)4-5-24(34)22(26)14-33)13-25-23(16-41-31)27(37-11-9-29(2,39)17-37)36-28(35-25)40-18-30-7-3-10-38(30)15-20(32)12-30/h4-5,19-20,39H,3,6-13,15-18,34H2,1-2H3	RHZYQPDOHSHFRI-UHFFFAOYSA-N	437045	US20260022132, Compound 667a	GTPase KRas [G12V]	Homo sapiens			 240						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437045	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437045&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490086	439658674							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212342	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC[C@](C)(O)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C31H39FN6O3/c1-19-6-8-31(26-21(19)4-5-24(34)22(26)14-33)13-25-23(16-41-31)27(37-11-9-29(2,39)17-37)36-28(35-25)40-18-30-7-3-10-38(30)15-20(32)12-30/h4-5,19-20,39H,3,6-13,15-18,34H2,1-2H3	RHZYQPDOHSHFRI-UHFFFAOYSA-N	437046	US20260022132, Compound 667b	GTPase KRas [G12V]	Homo sapiens			 83.0						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437046	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437046&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490088	439658675							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212343	C[C@@H]1[C@@H](O)CN1c1nc(OC[C@@]23CCCN2C[C@H](F)C3)nc2c1CO[C@@]1(CC[C@H](C)c3ccc(N)c(C#N)c31)C2	InChI=1S/C30H37FN6O3/c1-17-6-8-30(26-20(17)4-5-23(33)21(26)12-32)11-24-22(15-40-30)27(37-14-25(38)18(37)2)35-28(34-24)39-16-29-7-3-9-36(29)13-19(31)10-29/h4-5,17-19,25,38H,3,6-11,13-16,33H2,1-2H3	HAZGXRJJHFSEGK-UHFFFAOYSA-N	437047	US20260022132, Compound 668a	GTPase KRas [G12V]	Homo sapiens			 5.50						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437047	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437047&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490087	439658676							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212344	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4C[C@@H](O)[C@@H]4C)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C30H37FN6O3/c1-17-6-8-30(26-20(17)4-5-23(33)21(26)12-32)11-24-22(15-40-30)27(37-14-25(38)18(37)2)35-28(34-24)39-16-29-7-3-9-36(29)13-19(31)10-29/h4-5,17-19,25,38H,3,6-11,13-16,33H2,1-2H3	HAZGXRJJHFSEGK-UHFFFAOYSA-N	437048	US20260022132, Compound 668b	GTPase KRas [G12V]	Homo sapiens			 3.90						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437048	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437048&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490090	439658677							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212345	C[C@@H]1[C@H](O)CN1c1nc(OC[C@@]23CCCN2C[C@H](F)C3)nc2c1CO[C@@]1(CC[C@H](C)c3ccc(N)c(C#N)c31)C2	InChI=1S/C30H37FN6O3/c1-17-6-8-30(26-20(17)4-5-23(33)21(26)12-32)11-24-22(15-40-30)27(37-14-25(38)18(37)2)35-28(34-24)39-16-29-7-3-9-36(29)13-19(31)10-29/h4-5,17-19,25,38H,3,6-11,13-16,33H2,1-2H3	HAZGXRJJHFSEGK-UHFFFAOYSA-N	437049	US20260022132, Compound 668c	GTPase KRas [G12V]	Homo sapiens			 2.60						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437049	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437049&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490089	439658678							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212346	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4C[C@H](O)[C@@H]4C)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C30H37FN6O3/c1-17-6-8-30(26-20(17)4-5-23(33)21(26)12-32)11-24-22(15-40-30)27(37-14-25(38)18(37)2)35-28(34-24)39-16-29-7-3-9-36(29)13-19(31)10-29/h4-5,17-19,25,38H,3,6-11,13-16,33H2,1-2H3	HAZGXRJJHFSEGK-UHFFFAOYSA-N	437050	US20260022132, Compound 668d	GTPase KRas [G12V]	Homo sapiens			 4.40						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437050	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437050&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490091	439658679							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212347	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC(CCO)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C31H39FN6O3/c1-19-5-8-31(27-22(19)3-4-25(34)23(27)13-33)12-26-24(17-41-31)28(37-14-20(15-37)6-10-39)36-29(35-26)40-18-30-7-2-9-38(30)16-21(32)11-30/h3-4,19-21,39H,2,5-12,14-18,34H2,1H3	OEPJUTRWLIPJRE-UHFFFAOYSA-N	437051	US20260022132, Compound 669a	GTPase KRas [G12V]	Homo sapiens			 130						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437051	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437051&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490092	439658680							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212348	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC(O)(C(C)(C)C)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C33H43FN6O3/c1-20-8-10-32(27-22(20)6-7-25(36)23(27)14-35)13-26-24(16-43-32)28(39-17-33(41,18-39)30(2,3)4)38-29(37-26)42-19-31-9-5-11-40(31)15-21(34)12-31/h6-7,20-21,41H,5,8-13,15-19,36H2,1-4H3	LEBPRHNKANXUBX-UHFFFAOYSA-N	437052	US20260022132, Compound 670a	GTPase KRas [G12V]	Homo sapiens			>500						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437052	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437052&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490093	439658681							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212349	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC[C@@H]4C(C)(C)O)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H41FN6O3/c1-19-7-10-32(27-21(19)5-6-24(35)22(27)15-34)14-25-23(17-42-32)28(39-12-8-26(39)30(2,3)40)37-29(36-25)41-18-31-9-4-11-38(31)16-20(33)13-31/h5-6,19-20,26,40H,4,7-14,16-18,35H2,1-3H3	PIUVGUIJJUWTSQ-UHFFFAOYSA-N	437053	US20260022132, Compound 671a	GTPase KRas [G12V]	Homo sapiens			 5.70						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437053	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437053&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490094	439658682							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212350	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC[C@H]4C(C)(C)O)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H41FN6O3/c1-19-7-10-32(27-21(19)5-6-24(35)22(27)15-34)14-25-23(17-42-32)28(39-12-8-26(39)30(2,3)40)37-29(36-25)41-18-31-9-4-11-38(31)16-20(33)13-31/h5-6,19-20,26,40H,4,7-14,16-18,35H2,1-3H3	PIUVGUIJJUWTSQ-UHFFFAOYSA-N	437054	US20260022132, Compound 671b	GTPase KRas [G12V]	Homo sapiens			 7.40						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437054	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437054&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490095	439658683							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212351	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC5(CCC(O)CC5)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C34H43FN6O3/c1-21-5-11-34(29-24(21)3-4-27(37)25(29)15-36)14-28-26(17-44-34)30(40-18-32(19-40)9-6-23(42)7-10-32)39-31(38-28)43-20-33-8-2-12-41(33)16-22(35)13-33/h3-4,21-23,42H,2,5-14,16-20,37H2,1H3	DYVRXMUNGMIXCZ-UHFFFAOYSA-N	437055	US20260022132, Compound 672a	GTPase KRas [G12V]	Homo sapiens			>500						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437055	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437055&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490096	439658684							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212352	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC[C@]45CC[C@@H](O)OC5)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C33H41FN6O4/c1-20-5-9-33(28-22(20)3-4-25(36)23(28)15-35)14-26-24(17-44-33)29(40-12-10-31(40)8-6-27(41)42-18-31)38-30(37-26)43-19-32-7-2-11-39(32)16-21(34)13-32/h3-4,20-21,27,41H,2,5-14,16-19,36H2,1H3	NGSLNXBNRYSEQS-UHFFFAOYSA-N	437056	US20260022132, Compound 673a	GTPase KRas [G12V]	Homo sapiens			 4.00						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437056	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437056&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490097	439658685							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212353	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC(c5nccn5C)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C33H39FN8O2/c1-20-6-8-33(28-23(20)4-5-26(36)24(28)14-35)13-27-25(18-44-33)30(41-15-21(16-41)29-37-9-11-40(29)2)39-31(38-27)43-19-32-7-3-10-42(32)17-22(34)12-32/h4-5,9,11,20-22H,3,6-8,10,12-13,15-19,36H2,1-2H3	NTIFQLBRUDLBJP-UHFFFAOYSA-N	437057	US20260022132, Compound 674a	GTPase KRas [G12V]	Homo sapiens			 260						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437057	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437057&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490098	439658686							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212354	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC(c5cnn(C)c5)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C33H39FN8O2/c1-20-6-8-33(29-24(20)4-5-27(36)25(29)12-35)11-28-26(18-44-33)30(41-15-22(16-41)21-13-37-40(2)14-21)39-31(38-28)43-19-32-7-3-9-42(32)17-23(34)10-32/h4-5,13-14,20,22-23H,3,6-11,15-19,36H2,1-2H3	OARBUVORUZSPJB-UHFFFAOYSA-N	437058	US20260022132, Compound 675a	GTPase KRas [G12V]	Homo sapiens			 33.0						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437058	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437058&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490099	439658687							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212355	COCC1CC2(C1)CN(c1nc(OC[C@@]34CCCN3C[C@H](F)C4)nc3c1CO[C@@]1(CC[C@H](C)c4ccc(N)c(C#N)c41)C3)C2	InChI=1S/C34H43FN6O3/c1-21-6-8-34(29-24(21)4-5-27(37)25(29)14-36)13-28-26(17-44-34)30(40-18-32(19-40)10-22(11-32)16-42-2)39-31(38-28)43-20-33-7-3-9-41(33)15-23(35)12-33/h4-5,21-23H,3,6-13,15-20,37H2,1-2H3	JZOIFSKUQHLWGY-UHFFFAOYSA-N	437059	US20260022132, Compound 676a	GTPase KRas [G12V]	Homo sapiens			 1300						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437059	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437059&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490100	439658688							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212356	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC(C)(CO)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C31H39FN6O3/c1-19-6-8-31(26-21(19)4-5-24(34)22(26)12-33)11-25-23(14-41-31)27(37-15-29(2,16-37)17-39)36-28(35-25)40-18-30-7-3-9-38(30)13-20(32)10-30/h4-5,19-20,39H,3,6-11,13-18,34H2,1-2H3	RADYTEUNECTYEZ-UHFFFAOYSA-N	437060	US20260022132, Compound 677a	GTPase KRas [G12V]	Homo sapiens			 220						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437060	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437060&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490101	439658689							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212357	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC5(CCOCC5)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C33H41FN6O3/c1-21-5-7-33(28-23(21)3-4-26(36)24(28)15-35)14-27-25(17-43-33)29(39-18-31(19-39)8-11-41-12-9-31)38-30(37-27)42-20-32-6-2-10-40(32)16-22(34)13-32/h3-4,21-22H,2,5-14,16-20,36H2,1H3	RWMCLNYUTUZALR-UHFFFAOYSA-N	437061	US20260022132, Compound 678a	GTPase KRas [G12V]	Homo sapiens			>500						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437061	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437061&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490102	439658690							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212358	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC5(CCCCO5)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C33H41FN6O3/c1-21-7-10-33(28-23(21)5-6-26(36)24(28)15-35)14-27-25(17-43-33)29(39-18-32(19-39)9-2-3-12-42-32)38-30(37-27)41-20-31-8-4-11-40(31)16-22(34)13-31/h5-6,21-22H,2-4,7-14,16-20,36H2,1H3	SWCJKDBUTIOJIX-UHFFFAOYSA-N	437062	US20260022132, Compound 679a	GTPase KRas [G12V]	Homo sapiens			 400						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437062	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437062&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490103	439658691							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212359	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4C[C@@H]5C[C@@H](CO)C[C@@H]54)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C33H41FN6O3/c1-19-5-7-33(29-23(19)3-4-26(36)24(29)13-35)12-27-25(17-43-33)30(40-14-21-9-20(16-41)10-28(21)40)38-31(37-27)42-18-32-6-2-8-39(32)15-22(34)11-32/h3-4,19-22,28,41H,2,5-12,14-18,36H2,1H3	XMPBJAMJAIXJNB-UHFFFAOYSA-N	437063	US20260022132, Compound 680a	GTPase KRas [G12V]	Homo sapiens			 20.0						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437063	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437063&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490104	439658692							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212360	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4C[C@@H]5C[C@@H](CO)C[C@@H]54)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C33H41FN6O3/c1-19-5-7-33(29-23(19)3-4-26(36)24(29)13-35)12-27-25(17-43-33)30(40-14-21-9-20(16-41)10-28(21)40)38-31(37-27)42-18-32-6-2-8-39(32)15-22(34)11-32/h3-4,19-22,28,41H,2,5-12,14-18,36H2,1H3	XMPBJAMJAIXJNB-UHFFFAOYSA-N	437064	US20260022132, Compound 680b	GTPase KRas [G12V]	Homo sapiens			 360						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437064	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437064&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490105	439658693							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212361	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4C[C@H]5C[C@H](CO)C[C@H]54)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C33H41FN6O3/c1-19-5-7-33(29-23(19)3-4-26(36)24(29)13-35)12-27-25(17-43-33)30(40-14-21-9-20(16-41)10-28(21)40)38-31(37-27)42-18-32-6-2-8-39(32)15-22(34)11-32/h3-4,19-22,28,41H,2,5-12,14-18,36H2,1H3	XMPBJAMJAIXJNB-UHFFFAOYSA-N	437065	US20260022132, Compound 680c	GTPase KRas [G12V]	Homo sapiens			 14.0						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437065	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437065&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490106	439658694							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212362	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4C[C@H]5OCC[C@H]54)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C31H37FN6O3/c1-18-5-8-31(27-20(18)3-4-23(34)21(27)13-33)12-24-22(16-41-31)28(38-15-26-25(38)6-10-39-26)36-29(35-24)40-17-30-7-2-9-37(30)14-19(32)11-30/h3-4,18-19,25-26H,2,5-12,14-17,34H2,1H3	PGAOJZVDGUIRGK-UHFFFAOYSA-N	437066	US20260022132, Compound 681a	GTPase KRas [G12V]	Homo sapiens			 2.30						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437066	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437066&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490107	439658695							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212363	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC5(CCN(C)C5=O)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C33H40FN7O3/c1-20-6-8-33(27-22(20)4-5-25(36)23(27)14-35)13-26-24(16-44-33)28(40-17-31(18-40)9-11-39(2)29(31)42)38-30(37-26)43-19-32-7-3-10-41(32)15-21(34)12-32/h4-5,20-21H,3,6-13,15-19,36H2,1-2H3	QNOPBTNFFKZDRE-UHFFFAOYSA-N	437067	US20260022132, Compound 682a	GTPase KRas [G12V]	Homo sapiens			 120						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437067	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437067&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490108	439658696							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212364	CC(C)CC1(O)CN(c2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc3c2CO[C@@]2(CC[C@H](C)c4ccc(N)c(C#N)c42)C3)C1	InChI=1S/C33H43FN6O3/c1-20(2)11-32(41)17-39(18-32)29-25-16-43-33(9-7-21(3)23-5-6-26(36)24(14-35)28(23)33)13-27(25)37-30(38-29)42-19-31-8-4-10-40(31)15-22(34)12-31/h5-6,20-22,41H,4,7-13,15-19,36H2,1-3H3	GLFORMZXSDATFM-UHFFFAOYSA-N	437068	US20260022132, Compound 683a	GTPase KRas [G12V]	Homo sapiens			 170						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437068	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437068&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490111	439658697							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212365	CCC1(O)CN(c2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc3c2CO[C@@]2(CC[C@H](C)c4ccc(N)c(C#N)c42)C3)C1	InChI=1S/C31H39FN6O3/c1-3-30(39)16-37(17-30)27-23-15-41-31(9-7-19(2)21-5-6-24(34)22(13-33)26(21)31)12-25(23)35-28(36-27)40-18-29-8-4-10-38(29)14-20(32)11-29/h5-6,19-20,39H,3-4,7-12,14-18,34H2,1-2H3	GIKNGOYZOZIOJW-UHFFFAOYSA-N	437069	US20260022132, Compound 684a	GTPase KRas [G12V]	Homo sapiens			 270						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437069	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437069&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490109	439658698							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212366	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4C5COCC4C5)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C31H37FN6O3/c1-18-5-7-31(27-22(18)3-4-25(34)23(27)12-33)11-26-24(16-41-31)28(38-20-9-21(38)15-39-14-20)36-29(35-26)40-17-30-6-2-8-37(30)13-19(32)10-30/h3-4,18-21H,2,5-11,13-17,34H2,1H3	ITBFBMMITFHNJQ-UHFFFAOYSA-N	437070	US20260022132, Compound 685a	GTPase KRas [G12V]	Homo sapiens			 9.00						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437070	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437070&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490112	439658699							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212367	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC(C)(CCO)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H41FN6O3/c1-20-6-8-32(27-22(20)4-5-25(35)23(27)14-34)13-26-24(16-42-32)28(38-17-30(2,18-38)9-11-40)37-29(36-26)41-19-31-7-3-10-39(31)15-21(33)12-31/h4-5,20-21,40H,3,6-13,15-19,35H2,1-2H3	KQDSBXUSZMYGFZ-UHFFFAOYSA-N	437071	US20260022132, Compound 686a	GTPase KRas [G12V]	Homo sapiens			 240						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437071	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437071&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490110	439658700							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212368	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC(c5cncn5C)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C33H39FN8O2/c1-20-6-8-33(29-23(20)4-5-26(36)24(29)12-35)11-27-25(17-44-33)30(41-14-21(15-41)28-13-37-19-40(28)2)39-31(38-27)43-18-32-7-3-9-42(32)16-22(34)10-32/h4-5,13,19-22H,3,6-11,14-18,36H2,1-2H3	FWPMVJQNZGKILH-UHFFFAOYSA-N	437073	US20260022132, Compound 687a	GTPase KRas [G12V]	Homo sapiens			 1.10						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437073	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437073&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490115	439658702							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212369	COCC1CN(c2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc3c2CO[C@@]2(CC[C@H](C)c4ccc(N)c(C#N)c42)C3)C1(C)C	InChI=1S/C33H43FN6O3/c1-20-8-10-33(28-23(20)6-7-26(36)24(28)14-35)13-27-25(18-43-33)29(40-15-21(17-41-4)31(40,2)3)38-30(37-27)42-19-32-9-5-11-39(32)16-22(34)12-32/h6-7,20-22H,5,8-13,15-19,36H2,1-4H3	ILXODEODKSXZRR-UHFFFAOYSA-N	437074	US20260022132, Compound 688a	GTPase KRas [G12V]	Homo sapiens			 13.0						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437074	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437074&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490114	439658703							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212370	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4C[C@@H](CO)C4(C)C)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H41FN6O3/c1-19-7-9-32(27-22(19)5-6-25(35)23(27)13-34)12-26-24(17-42-32)28(39-14-20(16-40)30(39,2)3)37-29(36-26)41-18-31-8-4-10-38(31)15-21(33)11-31/h5-6,19-21,40H,4,7-12,14-18,35H2,1-3H3	RAZXEQVBCQQQTB-UHFFFAOYSA-N	437075	US20260022132, Compound 689a	GTPase KRas [G12V]	Homo sapiens			 0.680						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437075	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437075&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490116	439658704							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212371	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4C[C@H](CO)C4(C)C)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H41FN6O3/c1-19-7-9-32(27-22(19)5-6-25(35)23(27)13-34)12-26-24(17-42-32)28(39-14-20(16-40)30(39,2)3)37-29(36-26)41-18-31-8-4-10-38(31)15-21(33)11-31/h5-6,19-21,40H,4,7-12,14-18,35H2,1-3H3	RAZXEQVBCQQQTB-UHFFFAOYSA-N	437076	US20260022132, Compound 689b	GTPase KRas [G12V]	Homo sapiens			 26.0						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437076	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437076&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490120	439658705							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212372	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC(c5ccn(C)n5)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C33H39FN8O2/c1-20-6-9-33(29-23(20)4-5-26(36)24(29)14-35)13-28-25(18-44-33)30(41-15-21(16-41)27-7-11-40(2)39-27)38-31(37-28)43-19-32-8-3-10-42(32)17-22(34)12-32/h4-5,7,11,20-22H,3,6,8-10,12-13,15-19,36H2,1-2H3	UQPGBLZRMWBOOM-UHFFFAOYSA-N	437077	US20260022132, Compound 690a	GTPase KRas [G12V]	Homo sapiens			 59.0						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437077	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437077&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490118	439658706							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212373	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC(C(F)(F)CO)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C31H37F3N6O3/c1-18-5-7-30(26-21(18)3-4-24(36)22(26)11-35)10-25-23(15-43-30)27(39-12-19(13-39)31(33,34)16-41)38-28(37-25)42-17-29-6-2-8-40(29)14-20(32)9-29/h3-4,18-20,41H,2,5-10,12-17,36H2,1H3	PHTPNMRDEHLAOZ-UHFFFAOYSA-N	437078	US20260022132, Compound 691a	GTPase KRas [G12V]	Homo sapiens			 360						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437078	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437078&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490119	439658707							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212374	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC(C5CCOC5)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C33H41FN6O3/c1-20-5-8-33(29-24(20)3-4-27(36)25(29)13-35)12-28-26(18-43-33)30(39-14-22(15-39)21-6-10-41-17-21)38-31(37-28)42-19-32-7-2-9-40(32)16-23(34)11-32/h3-4,20-23H,2,5-12,14-19,36H2,1H3	TYVUMKRYXKTJFV-UHFFFAOYSA-N	437079	US20260022132, Compound 692a	GTPase KRas [G12V]	Homo sapiens			 770						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437079	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437079&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490121	439658708							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212375	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4C[C@H]5COCC[C@H]54)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H39FN6O3/c1-19-5-8-32(28-22(19)3-4-25(35)23(28)13-34)12-26-24(17-42-32)29(39-14-20-16-40-10-6-27(20)39)37-30(36-26)41-18-31-7-2-9-38(31)15-21(33)11-31/h3-4,19-21,27H,2,5-12,14-18,35H2,1H3	NHSXLCMBTSEHIC-UHFFFAOYSA-N	437080	US20260022132, Compound 693a	GTPase KRas [G12V]	Homo sapiens			 14.0						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437080	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437080&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490122	439658709							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212376	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC5(CC5F)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C31H36F2N6O2/c1-18-5-7-31(26-20(18)3-4-23(35)21(26)12-34)10-24-22(14-41-31)27(38-15-29(16-38)11-25(29)33)37-28(36-24)40-17-30-6-2-8-39(30)13-19(32)9-30/h3-4,18-19,25H,2,5-11,13-17,35H2,1H3	VKIMATKEOQARKR-UHFFFAOYSA-N	437081	US20260022132, Compound 694a	GTPase KRas [G12V]	Homo sapiens			 150						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437081	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437081&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490123	439658710							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212377	COC(C)(C)C1CCN1c1nc(OC[C@@]23CCCN2C[C@H](F)C3)nc2c1CO[C@@]1(CC[C@H](C)c3ccc(N)c(C#N)c31)C2	InChI=1S/C33H43FN6O3/c1-20-8-11-33(28-22(20)6-7-25(36)23(28)16-35)15-26-24(18-43-33)29(40-13-9-27(40)31(2,3)41-4)38-30(37-26)42-19-32-10-5-12-39(32)17-21(34)14-32/h6-7,20-21,27H,5,8-15,17-19,36H2,1-4H3	TZOISURSACEINO-UHFFFAOYSA-N	437083	US20260022132, Compound 695a	GTPase KRas [G12V]	Homo sapiens			 46.0						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437083	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437083&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490125	439658712							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212378	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC5(C4)OC[C@H]4C[C@H]45)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C33H39FN6O3/c1-19-5-7-32(28-22(19)3-4-26(36)23(28)12-35)11-27-24(15-43-32)29(39-16-33(17-39)25-9-20(25)14-42-33)38-30(37-27)41-18-31-6-2-8-40(31)13-21(34)10-31/h3-4,19-21,25H,2,5-11,13-18,36H2,1H3	MZPFSDIGYAWRSO-UHFFFAOYSA-N	437084	US20260022132, Compound 696a	GTPase KRas [G12V]	Homo sapiens			>500						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437084	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437084&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490126	439658713							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212379	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC(N5CCCOCC5)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C34H44FN7O3/c1-22-6-8-34(30-25(22)4-5-28(37)26(30)16-36)15-29-27(20-45-34)31(41-18-24(19-41)40-9-3-12-43-13-11-40)39-32(38-29)44-21-33-7-2-10-42(33)17-23(35)14-33/h4-5,22-24H,2-3,6-15,17-21,37H2,1H3	OJKGXIZJWUZOOJ-UHFFFAOYSA-N	437085	US20260022132, Compound 697a	GTPase KRas [G12V]	Homo sapiens			>500						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437085	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437085&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490127	439658714							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212380	CC1CCC2(CO1)CN(c1nc(OC[C@@]34CCCN3C[C@H](F)C4)nc3c1CO[C@@]1(CC[C@H](C)c4ccc(N)c(C#N)c41)C3)C2	InChI=1S/C34H43FN6O3/c1-21-6-10-34(29-24(21)4-5-27(37)25(29)14-36)13-28-26(16-44-34)30(40-17-32(18-40)9-7-22(2)42-19-32)39-31(38-28)43-20-33-8-3-11-41(33)15-23(35)12-33/h4-5,21-23H,3,6-13,15-20,37H2,1-2H3	KHVVWAUBOUQDPW-UHFFFAOYSA-N	437086	US20260022132, Compound 698a	GTPase KRas [G12V]	Homo sapiens			>500						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437086	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437086&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490128	439658715							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212381	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC(N5CCOCC5)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C33H42FN7O3/c1-21-5-7-33(29-24(21)3-4-27(36)25(29)15-35)14-28-26(19-44-33)30(40-17-23(18-40)39-9-11-42-12-10-39)38-31(37-28)43-20-32-6-2-8-41(32)16-22(34)13-32/h3-4,21-23H,2,5-14,16-20,36H2,1H3	ZPASFWWOUWZJSJ-UHFFFAOYSA-N	437087	US20260022132, Compound 699a	GTPase KRas [G12V]	Homo sapiens			>500						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437087	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437087&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490129	439658716							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212382	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC(C5CCO5)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H39FN6O3/c1-19-5-8-32(28-22(19)3-4-25(35)23(28)13-34)12-26-24(17-42-32)29(38-14-20(15-38)27-6-10-40-27)37-30(36-26)41-18-31-7-2-9-39(31)16-21(33)11-31/h3-4,19-21,27H,2,5-12,14-18,35H2,1H3	RGKCELPOEVMITC-UHFFFAOYSA-N	437088	US20260022132, Compound 700a	GTPase KRas [G12V]	Homo sapiens			 390						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437088	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437088&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490130	439658717							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212383	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC(F)(c5cccnc5)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C34H37F2N7O2/c1-21-7-9-34(29-24(21)5-6-27(38)25(29)14-37)13-28-26(17-45-34)30(42-18-33(36,19-42)22-4-2-10-39-15-22)41-31(40-28)44-20-32-8-3-11-43(32)16-23(35)12-32/h2,4-6,10,15,21,23H,3,7-9,11-13,16-20,38H2,1H3	PHFORYPWFYSLAN-UHFFFAOYSA-N	437089	US20260022132, Compound 701a	GTPase KRas [G12V]	Homo sapiens			 3.70						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437089	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437089&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490131	439658718							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212384	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4C[C@@H](O)C4(C)C)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C31H39FN6O3/c1-18-7-9-31(26-20(18)5-6-23(34)21(26)13-33)12-24-22(16-41-31)27(38-15-25(39)29(38,2)3)36-28(35-24)40-17-30-8-4-10-37(30)14-19(32)11-30/h5-6,18-19,25,39H,4,7-12,14-17,34H2,1-3H3	BGLKGOQSWPMPNZ-UHFFFAOYSA-N	437090	US20260022132, Compound 702a	GTPase KRas [G12V]	Homo sapiens			 1.20						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437090	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437090&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490132	439658719							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212385	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4C[C@H](O)C4(C)C)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C31H39FN6O3/c1-18-7-9-31(26-20(18)5-6-23(34)21(26)13-33)12-24-22(16-41-31)27(38-15-25(39)29(38,2)3)36-28(35-24)40-17-30-8-4-10-37(30)14-19(32)11-30/h5-6,18-19,25,39H,4,7-12,14-17,34H2,1-3H3	BGLKGOQSWPMPNZ-UHFFFAOYSA-N	437091	US20260022132, Compound 702b	GTPase KRas [G12V]	Homo sapiens			 0.990						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437091	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437091&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490133	439658720							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212386	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC(F)(CO)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C30H36F2N6O3/c1-18-5-7-30(25-20(18)3-4-23(34)21(25)11-33)10-24-22(13-41-30)26(37-14-28(32,15-37)16-39)36-27(35-24)40-17-29-6-2-8-38(29)12-19(31)9-29/h3-4,18-19,39H,2,5-10,12-17,34H2,1H3	SKTXEVMEZQMWJG-UHFFFAOYSA-N	437092	US20260022132, Compound 703a	GTPase KRas [G12V]	Homo sapiens			 81.0						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437092	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437092&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490134	439658721							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212387	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC5(CCC(C)(C)OC5)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C35H45FN6O3/c1-22-7-9-35(29-24(22)5-6-27(38)25(29)15-37)14-28-26(17-44-35)30(41-18-33(19-41)11-10-32(2,3)45-20-33)40-31(39-28)43-21-34-8-4-12-42(34)16-23(36)13-34/h5-6,22-23H,4,7-14,16-21,38H2,1-3H3	HAJXALSFHICKQI-UHFFFAOYSA-N	437093	US20260022132, Compound 704a	GTPase KRas [G12V]	Homo sapiens			>500						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437093	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437093&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493952	439658722							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212388	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC(O)(c5cccc(F)c5)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C35H38F2N6O3/c1-21-8-10-35(30-25(21)6-7-28(39)26(30)15-38)14-29-27(17-46-35)31(42-18-34(44,19-42)22-4-2-5-23(36)12-22)41-32(40-29)45-20-33-9-3-11-43(33)16-24(37)13-33/h2,4-7,12,21,24,44H,3,8-11,13-14,16-20,39H2,1H3	SBFNRIMHFJJXAG-UHFFFAOYSA-N	437094	US20260022132, Compound 705a	GTPase KRas [G12V]	Homo sapiens			 350						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437094	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437094&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134490136	439658723							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212389	N#Cc1c(N)ccc2c1[C@]1(CCC2)Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc([C@@H]3CCO3)c2CO1	InChI=1S/C28H32FN5O3/c29-18-11-27(7-2-9-34(27)14-18)16-36-26-32-22-12-28(37-15-20(22)25(33-26)23-6-10-35-23)8-1-3-17-4-5-21(31)19(13-30)24(17)28/h4-5,18,23H,1-3,6-12,14-16,31H2	KVASZMPUFFRBPX-UHFFFAOYSA-N	437095	US20260022132, Compound 706a	GTPase KRas [G12V]	Homo sapiens			 540						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437095	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437095&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493930	439658724							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212390	N#Cc1c(N)ccc2c1[C@@]1(CCC2)Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc([C@@H]3CCO3)c2CO1	InChI=1S/C28H32FN5O3/c29-18-11-27(7-2-9-34(27)14-18)16-36-26-32-22-12-28(37-15-20(22)25(33-26)23-6-10-35-23)8-1-3-17-4-5-21(31)19(13-30)24(17)28/h4-5,18,23H,1-3,6-12,14-16,31H2	KVASZMPUFFRBPX-UHFFFAOYSA-N	437096	US20260022132, Compound 706b	GTPase KRas [G12V]	Homo sapiens			>500						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437096	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437096&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493917	439658725							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212391	N#Cc1c(N)ccc2c1[C@@]1(CCC2)Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc([C@H]3CCO3)c2CO1	InChI=1S/C28H32FN5O3/c29-18-11-27(7-2-9-34(27)14-18)16-36-26-32-22-12-28(37-15-20(22)25(33-26)23-6-10-35-23)8-1-3-17-4-5-21(31)19(13-30)24(17)28/h4-5,18,23H,1-3,6-12,14-16,31H2	KVASZMPUFFRBPX-UHFFFAOYSA-N	437097	US20260022132, Compound 706c	GTPase KRas [G12V]	Homo sapiens			>500						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437097	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437097&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493630	439658726							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212392	N#Cc1c(N)ccc2c1[C@]1(CCC2)Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc([C@H]3CCO3)c2CO1	InChI=1S/C28H32FN5O3/c29-18-11-27(7-2-9-34(27)14-18)16-36-26-32-22-12-28(37-15-20(22)25(33-26)23-6-10-35-23)8-1-3-17-4-5-21(31)19(13-30)24(17)28/h4-5,18,23H,1-3,6-12,14-16,31H2	KVASZMPUFFRBPX-UHFFFAOYSA-N	437098	US20260022132, Compound 706d	GTPase KRas [G12V]	Homo sapiens			 130						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437098	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437098&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493816	439658727							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212393	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC5(C4)CC(O)(C(F)F)C5)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C33H39F3N6O3/c1-19-5-7-33(26-21(19)3-4-24(38)22(26)11-37)10-25-23(13-45-33)27(41-16-30(17-41)14-32(43,15-30)28(35)36)40-29(39-25)44-18-31-6-2-8-42(31)12-20(34)9-31/h3-4,19-20,28,43H,2,5-10,12-18,38H2,1H3	NFIXLLBEZQDXND-UHFFFAOYSA-N	437099	US20260022132, Compound 707a	GTPase KRas [G12V]	Homo sapiens			>500						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437099	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437099&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493953	439658728							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212394	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC(O)(c5ccc(F)cc5)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C35H38F2N6O3/c1-21-9-11-35(30-25(21)7-8-28(39)26(30)15-38)14-29-27(17-46-35)31(42-18-34(44,19-42)22-3-5-23(36)6-4-22)41-32(40-29)45-20-33-10-2-12-43(33)16-24(37)13-33/h3-8,21,24,44H,2,9-14,16-20,39H2,1H3	KTEMIAYQLJBCHP-UHFFFAOYSA-N	437100	US20260022132, Compound 708a	GTPase KRas [G12V]	Homo sapiens			 270						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437100	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437100&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493914	439658729							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212395	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC(Oc5ccncc5)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C34H38FN7O3/c1-21-5-9-34(30-25(21)3-4-28(37)26(30)15-36)14-29-27(19-44-34)31(41-17-24(18-41)45-23-6-10-38-11-7-23)40-32(39-29)43-20-33-8-2-12-42(33)16-22(35)13-33/h3-4,6-7,10-11,21-22,24H,2,5,8-9,12-14,16-20,37H2,1H3	NGEMLPCTDKTGJQ-UHFFFAOYSA-N	437101	US20260022132, Compound 709a	GTPase KRas [G12V]	Homo sapiens			 3.30						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437101	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437101&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493815	439658730							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212396	Cc1cc(C)n(C2CN(c3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc4c3CO[C@@]3(CC[C@H](C)c5ccc(N)c(C#N)c53)C4)C2)n1	InChI=1S/C34H41FN8O2/c1-20-7-9-34(30-25(20)5-6-28(37)26(30)14-36)13-29-27(18-45-34)31(41-16-24(17-41)43-22(3)11-21(2)40-43)39-32(38-29)44-19-33-8-4-10-42(33)15-23(35)12-33/h5-6,11,20,23-24H,4,7-10,12-13,15-19,37H2,1-3H3	RVXYFLMJCDLIAI-UHFFFAOYSA-N	437102	US20260022132, Compound 710a	GTPase KRas [G12V]	Homo sapiens			 710						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437102	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437102&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493789	439658731							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212397	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC(C)(N5CCOCC5)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C34H44FN7O3/c1-22-6-8-34(29-24(22)4-5-27(37)25(29)16-36)15-28-26(18-45-34)30(40-19-32(2,20-40)41-10-12-43-13-11-41)39-31(38-28)44-21-33-7-3-9-42(33)17-23(35)14-33/h4-5,22-23H,3,6-15,17-21,37H2,1-2H3	SYSYCIUWGSOCOF-UHFFFAOYSA-N	437103	US20260022132, Compound 711a	GTPase KRas [G12V]	Homo sapiens			>500						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437103	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437103&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493629	439658732							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212398	CC1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC(n5cnc6c5CCCC6)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C36H43FN8O2/c1-22-9-11-36(32-25(22)7-8-28(39)26(32)15-38)14-30-27(19-47-36)33(43-17-24(18-43)45-21-40-29-5-2-3-6-31(29)45)42-34(41-30)46-20-35-10-4-12-44(35)16-23(37)13-35/h7-8,21-24H,2-6,9-14,16-20,39H2,1H3	JEQQGCQAPBCHAG-UHFFFAOYSA-N	437104	US20260022132, Compound 712a	GTPase KRas [G12V]	Homo sapiens			 120						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437104	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437104&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134494079	439658733							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212399	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC(Oc5ccccn5)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C34H38FN7O3/c1-21-8-10-34(30-24(21)6-7-27(37)25(30)15-36)14-28-26(19-44-34)31(41-17-23(18-41)45-29-5-2-3-11-38-29)40-32(39-28)43-20-33-9-4-12-42(33)16-22(35)13-33/h2-3,5-7,11,21-23H,4,8-10,12-14,16-20,37H2,1H3	KTKPAFCOQQYOOI-UHFFFAOYSA-N	437105	US20260022132, Compound 713a	GTPase KRas [G12V]	Homo sapiens			 26.0						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437105	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437105&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134494090	439658734							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212400	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC(N5CCCC5=O)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C33H40FN7O3/c1-20-7-9-33(29-23(20)5-6-26(36)24(29)14-35)13-27-25(18-44-33)30(39-16-22(17-39)41-11-2-4-28(41)42)38-31(37-27)43-19-32-8-3-10-40(32)15-21(34)12-32/h5-6,20-22H,2-4,7-13,15-19,36H2,1H3	ZDLLFFUSCZWRNE-UHFFFAOYSA-N	437106	US20260022132, Compound 714a	GTPase KRas [G12V]	Homo sapiens			 110						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437106	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437106&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493947	439658735							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212401	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC(CO)(C5CC5)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C33H41FN6O3/c1-20-7-9-33(28-23(20)5-6-26(36)24(28)13-35)12-27-25(15-43-33)29(39-16-31(17-39,18-41)21-3-4-21)38-30(37-27)42-19-32-8-2-10-40(32)14-22(34)11-32/h5-6,20-22,41H,2-4,7-12,14-19,36H2,1H3	VTGQCTKQSCGGLZ-UHFFFAOYSA-N	437107	US20260022132, Compound 715a	GTPase KRas [G12V]	Homo sapiens			 480						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437107	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437107&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493639	439658736							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212402	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC(CN5CCOCC5)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C34H44FN7O3/c1-22-5-7-34(30-25(22)3-4-28(37)26(30)15-36)14-29-27(20-45-34)31(41-17-23(18-41)16-40-9-11-43-12-10-40)39-32(38-29)44-21-33-6-2-8-42(33)19-24(35)13-33/h3-4,22-24H,2,5-14,16-21,37H2,1H3	SHKGJMDQKYXTST-UHFFFAOYSA-N	437108	US20260022132, Compound 716a	GTPase KRas [G12V]	Homo sapiens			 96.0						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437108	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437108&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493818	439658737							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212403	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC5(CC(C(C)(C)O)C5)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C35H45FN6O3/c1-21-7-9-35(29-24(21)5-6-27(38)25(29)15-37)14-28-26(17-45-35)30(41-18-33(19-41)11-22(12-33)32(2,3)43)40-31(39-28)44-20-34-8-4-10-42(34)16-23(36)13-34/h5-6,21-23,43H,4,7-14,16-20,38H2,1-3H3	VWNGBVVDDGRQKF-UHFFFAOYSA-N	437109	US20260022132, Compound 717a	GTPase KRas [G12V]	Homo sapiens			 650						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437109	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437109&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493957	439658738							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212404	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC(C5COC5)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H39FN6O3/c1-19-5-7-32(28-23(19)3-4-26(35)24(28)11-34)10-27-25(17-42-32)29(38-12-20(13-38)21-15-40-16-21)37-30(36-27)41-18-31-6-2-8-39(31)14-22(33)9-31/h3-4,19-22H,2,5-10,12-18,35H2,1H3	VWTXOWOUCZCJLH-UHFFFAOYSA-N	437110	US20260022132, Compound 718a	GTPase KRas [G12V]	Homo sapiens			 310						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437110	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437110&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493637	439658739							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212405	COC1(C)CN(c2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc3c2CO[C@@]2(CC[C@H](C)c4ccc(N)c(C#N)c42)C3)C1	InChI=1S/C31H39FN6O3/c1-19-7-9-31(26-21(19)5-6-24(34)22(26)13-33)12-25-23(15-41-31)27(37-16-29(2,17-37)39-3)36-28(35-25)40-18-30-8-4-10-38(30)14-20(32)11-30/h5-6,19-20H,4,7-12,14-18,34H2,1-3H3	RLFIQODEAFQUKL-UHFFFAOYSA-N	437111	US20260022132, Compound 719a	GTPase KRas [G12V]	Homo sapiens			 680						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437111	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437111&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134494086	439658740							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212406	COC1CC2(CCN2c2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc3c2CO[C@@]2(CC[C@H](C)c4ccc(N)c(C#N)c42)C3)C1	InChI=1S/C33H41FN6O3/c1-20-6-8-33(28-23(20)4-5-26(36)24(28)16-35)15-27-25(18-43-33)29(40-11-9-31(40)13-22(14-31)41-2)38-30(37-27)42-19-32-7-3-10-39(32)17-21(34)12-32/h4-5,20-22H,3,6-15,17-19,36H2,1-2H3	WNBWJVWQXGXYQW-UHFFFAOYSA-N	437112	US20260022132, Compound 720a	GTPase KRas [G12V]	Homo sapiens			 0.540						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437112	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437112&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493926	439658741							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212407	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCC45CC(F)C5)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H38F2N6O2/c1-19-5-7-32(27-22(19)3-4-25(36)23(27)15-35)14-26-24(17-42-32)28(40-10-8-30(40)11-20(33)12-30)38-29(37-26)41-18-31-6-2-9-39(31)16-21(34)13-31/h3-4,19-21H,2,5-14,16-18,36H2,1H3	XGLLOWWUZHKVNQ-UHFFFAOYSA-N	437113	US20260022132, Compound 721a	GTPase KRas [G12V]	Homo sapiens			 0.650						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437113	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437113&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134494082	439658742							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212408	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC(C(N)=O)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C30H36FN7O3/c1-17-5-7-30(25-20(17)3-4-23(33)21(25)11-32)10-24-22(15-41-30)27(37-12-18(13-37)26(34)39)36-28(35-24)40-16-29-6-2-8-38(29)14-19(31)9-29/h3-4,17-19H,2,5-10,12-16,33H2,1H3,(H2,34,39)	LURFLURQZWBKQI-UHFFFAOYSA-N	437114	US20260022132, Compound 722a	GTPase KRas [G12V]	Homo sapiens			 14.0						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437114	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437114&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493919	439658743							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212409	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC5(CCC5O)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H39FN6O3/c1-19-5-9-32(27-21(19)3-4-24(35)22(27)13-34)12-25-23(15-42-32)28(38-16-30(17-38)8-6-26(30)40)37-29(36-25)41-18-31-7-2-10-39(31)14-20(33)11-31/h3-4,19-20,26,40H,2,5-12,14-18,35H2,1H3	SPLCFDYUUMJXKH-UHFFFAOYSA-N	437115	US20260022132, Compound 723a	GTPase KRas [G12V]	Homo sapiens			 600						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437115	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437115&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493928	439658744							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212410	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC5(CC(F)C5)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H38F2N6O2/c1-19-5-7-32(27-22(19)3-4-25(36)23(27)13-35)12-26-24(15-42-32)28(39-16-30(17-39)9-20(33)10-30)38-29(37-26)41-18-31-6-2-8-40(31)14-21(34)11-31/h3-4,19-21H,2,5-12,14-18,36H2,1H3	LYLLGRPNHKUIPR-UHFFFAOYSA-N	437116	US20260022132, Compound 724a	GTPase KRas [G12V]	Homo sapiens			>500						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437116	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437116&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493958	439658745							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212411	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC(C56CC(O)(C5)C6)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C34H41FN6O3/c1-20-5-7-34(28-23(20)3-4-26(37)24(28)11-36)10-27-25(15-44-34)29(40-12-21(13-40)31-16-33(42,17-31)18-31)39-30(38-27)43-19-32-6-2-8-41(32)14-22(35)9-32/h3-4,20-22,42H,2,5-10,12-19,37H2,1H3	CJMYECRWFZQTQZ-UHFFFAOYSA-N	437117	US20260022132, Compound 725a	GTPase KRas [G12V]	Homo sapiens			>500						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437117	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437117&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493934	439658746							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212412	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC5(CCC5C#N)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C33H38FN7O2/c1-20-5-9-33(28-23(20)3-4-26(37)24(28)14-36)12-27-25(16-43-33)29(40-17-31(18-40)8-6-21(31)13-35)39-30(38-27)42-19-32-7-2-10-41(32)15-22(34)11-32/h3-4,20-22H,2,5-12,15-19,37H2,1H3	WCCXVGMXYIWTDI-UHFFFAOYSA-N	437118	US20260022132, Compound 726a	GTPase KRas [G12V]	Homo sapiens			 170						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437118	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437118&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493855	439658747							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212413	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC5(CCCCOC5)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C34H43FN6O3/c1-22-7-10-34(29-24(22)5-6-27(37)25(29)15-36)14-28-26(17-44-34)30(40-18-32(19-40)8-2-3-12-42-20-32)39-31(38-28)43-21-33-9-4-11-41(33)16-23(35)13-33/h5-6,22-23H,2-4,7-14,16-21,37H2,1H3	MLDUARNWPALILR-UHFFFAOYSA-N	437119	US20260022132, Compound 727a	GTPase KRas [G12V]	Homo sapiens			>500						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437119	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437119&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134494097	439658748							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212414	CCOC1(C)CN(c2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc3c2CO[C@@]2(CC[C@H](C)c4ccc(N)c(C#N)c42)C3)C1	InChI=1S/C32H41FN6O3/c1-4-41-30(3)17-38(18-30)28-24-16-42-32(10-8-20(2)22-6-7-25(35)23(14-34)27(22)32)13-26(24)36-29(37-28)40-19-31-9-5-11-39(31)15-21(33)12-31/h6-7,20-21H,4-5,8-13,15-19,35H2,1-3H3	JZZWUUPRCSOSDQ-UHFFFAOYSA-N	437120	US20260022132, Compound 728a	GTPase KRas [G12V]	Homo sapiens			>500						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437120	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437120&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134494104	439658749							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212415	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4[C@@H]5C[C@H](O)C[C@H]4C5)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H39FN6O3/c1-18-5-7-32(28-23(18)3-4-26(35)24(28)14-34)13-27-25(16-42-32)29(39-20-9-21(39)11-22(40)10-20)37-30(36-27)41-17-31-6-2-8-38(31)15-19(33)12-31/h3-4,18-22,40H,2,5-13,15-17,35H2,1H3	LVTOPZCOFMBCJX-UHFFFAOYSA-N	437121	US20260022132, Compound 729a	GTPase KRas [G12V]	Homo sapiens			 8.90						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437121	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437121&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493938	439658750							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212416	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4[C@@H]5C[C@@H](O)C[C@H]4C5)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H39FN6O3/c1-18-5-7-32(28-23(18)3-4-26(35)24(28)14-34)13-27-25(16-42-32)29(39-20-9-21(39)11-22(40)10-20)37-30(36-27)41-17-31-6-2-8-38(31)15-19(33)12-31/h3-4,18-22,40H,2,5-13,15-17,35H2,1H3	LVTOPZCOFMBCJX-UHFFFAOYSA-N	437122	US20260022132, Compound 729b	GTPase KRas [G12V]	Homo sapiens			 14.0						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437122	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437122&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493829	439658751							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212417	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4CC(F)C5)nc(N4CC(C#N)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C30H34FN7O2/c1-18-5-7-30(26-21(18)3-4-24(34)22(26)12-33)10-25-23(16-40-30)27(37-13-19(11-32)14-37)36-28(35-25)39-17-29-6-2-8-38(29)15-20(31)9-29/h3-4,18-20H,2,5-10,13-17,34H2,1H3	NHSJNKDVVDRUFQ-UHFFFAOYSA-N	437123	US20260022132, Compound 730a	GTPase KRas [G12V]	Homo sapiens			 3.50						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437123	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437123&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134494103	439658752							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212418	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC5(CN(C)C(=O)C5(F)F)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C33H38F3N7O3/c1-19-6-8-32(26-21(19)4-5-24(38)22(26)12-37)11-25-23(14-46-32)27(42-16-30(17-42)15-41(2)28(44)33(30,35)36)40-29(39-25)45-18-31-7-3-9-43(31)13-20(34)10-31/h4-5,19-20H,3,6-11,13-18,38H2,1-2H3	IGHWUMYBADVSCN-UHFFFAOYSA-N	437124	US20260022132, Compound 731a	GTPase KRas [G12V]	Homo sapiens			 19.0						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437124	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437124&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493636	439658753							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212419	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC(F)(c5nccn5C)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C33H38F2N8O2/c1-20-6-8-33(27-22(20)4-5-25(37)23(27)14-36)13-26-24(16-45-33)28(42-17-32(35,18-42)29-38-9-11-41(29)2)40-30(39-26)44-19-31-7-3-10-43(31)15-21(34)12-31/h4-5,9,11,20-21H,3,6-8,10,12-13,15-19,37H2,1-2H3	KHWBFKKWNJWPTJ-UHFFFAOYSA-N	437125	US20260022132, Compound 732a	GTPase KRas [G12V]	Homo sapiens			 650						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437125	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437125&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493854	439658754							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212420	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC(F)(C#N)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C30H33F2N7O2/c1-18-5-7-30(25-20(18)3-4-23(35)21(25)11-33)10-24-22(13-41-30)26(38-15-28(32,14-34)16-38)37-27(36-24)40-17-29-6-2-8-39(29)12-19(31)9-29/h3-4,18-19H,2,5-10,12-13,15-17,35H2,1H3	UIFCSNBLNGOACW-UHFFFAOYSA-N	437126	US20260022132, Compound 733a	GTPase KRas [G12V]	Homo sapiens			 24.0						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437126	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437126&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493640	439658755							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212421	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC(F)(C(N)=O)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C30H35F2N7O3/c1-17-5-7-30(24-19(17)3-4-22(34)20(24)11-33)10-23-21(13-42-30)25(38-14-29(32,15-38)26(35)40)37-27(36-23)41-16-28-6-2-8-39(28)12-18(31)9-28/h3-4,17-18H,2,5-10,12-16,34H2,1H3,(H2,35,40)	FHAKTJZOGXRLDM-UHFFFAOYSA-N	437127	US20260022132, Compound 734a	GTPase KRas [G12V]	Homo sapiens			 22.0						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437127	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437127&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493909	439658756							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212422	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC(N5CC[C@@H](O)C5)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C33H42FN7O3/c1-20-5-8-33(29-24(20)3-4-27(36)25(29)13-35)12-28-26(18-44-33)30(40-15-22(16-40)39-10-6-23(42)17-39)38-31(37-28)43-19-32-7-2-9-41(32)14-21(34)11-32/h3-4,20-23,42H,2,5-12,14-19,36H2,1H3	DTOJLIMVXDZVMH-UHFFFAOYSA-N	437128	US20260022132, Compound 735a	GTPase KRas [G12V]	Homo sapiens			>500						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437128	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437128&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493840	439658757							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212423	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCC4CCC#N)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H38FN7O2/c1-20-7-10-32(28-23(20)5-6-26(36)24(28)16-35)15-27-25(18-42-32)29(40-13-8-22(40)4-2-11-34)38-30(37-27)41-19-31-9-3-12-39(31)17-21(33)14-31/h5-6,20-22H,2-4,7-10,12-15,17-19,36H2,1H3	ZLVMOSJEWOWJFO-UHFFFAOYSA-N	437129	US20260022132, Compound 736a	GTPase KRas [G12V]	Homo sapiens			 1.30						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437129	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437129&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493632	439658758							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212424	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCC45CC(CO)C5)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C33H41FN6O3/c1-20-5-7-33(28-23(20)3-4-26(36)24(28)15-35)14-27-25(18-43-33)29(40-10-8-31(40)11-21(12-31)17-41)38-30(37-27)42-19-32-6-2-9-39(32)16-22(34)13-32/h3-4,20-22,41H,2,5-14,16-19,36H2,1H3	ZYYGMFCRYVBUQH-UHFFFAOYSA-N	437130	US20260022132, Compound 737a	GTPase KRas [G12V]	Homo sapiens			 2.30						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437130	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437130&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493644	439658759							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212425	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC(Cc5cnn(C)c5)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C34H41FN8O2/c1-21-6-8-34(30-25(21)4-5-28(37)26(30)13-36)12-29-27(19-45-34)31(42-16-23(17-42)10-22-14-38-41(2)15-22)40-32(39-29)44-20-33-7-3-9-43(33)18-24(35)11-33/h4-5,14-15,21,23-24H,3,6-12,16-20,37H2,1-2H3	MWIPWQOFDPRIGP-UHFFFAOYSA-N	437131	US20260022132, Compound 738a	GTPase KRas [G12V]	Homo sapiens			 52.0						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437131	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437131&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493810	439658760							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212426	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC(C5(O)CCC5)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C33H41FN6O3/c1-20-6-10-33(28-23(20)4-5-26(36)24(28)14-35)13-27-25(18-43-33)29(39-15-21(16-39)32(41)8-2-9-32)38-30(37-27)42-19-31-7-3-11-40(31)17-22(34)12-31/h4-5,20-22,41H,2-3,6-13,15-19,36H2,1H3	UTPJIUVRYNRTCU-UHFFFAOYSA-N	437132	US20260022132, Compound 739a	GTPase KRas [G12V]	Homo sapiens			>500						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437132	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437132&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493932	439658761							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212427	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC(OC5COC5)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H39FN6O4/c1-19-5-7-32(28-23(19)3-4-26(35)24(28)11-34)10-27-25(17-42-32)29(38-13-21(14-38)43-22-15-40-16-22)37-30(36-27)41-18-31-6-2-8-39(31)12-20(33)9-31/h3-4,19-22H,2,5-10,12-18,35H2,1H3	CCJDWGBMHYHVFP-UHFFFAOYSA-N	437133	US20260022132, Compound 740a	GTPase KRas [G12V]	Homo sapiens			 72.0						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437133	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437133&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493860	439658762							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212428	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC[C@H]4CCO)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C31H39FN6O3/c1-19-5-9-31(27-22(19)3-4-25(34)23(27)15-33)14-26-24(17-41-31)28(38-11-6-21(38)7-12-39)36-29(35-26)40-18-30-8-2-10-37(30)16-20(32)13-30/h3-4,19-21,39H,2,5-14,16-18,34H2,1H3	ARBVWVRPIMHVPL-UHFFFAOYSA-N	437134	US20260022132, Compound 741a	GTPase KRas [G12V]	Homo sapiens			 3.70						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437134	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437134&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493959	439658763							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212429	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC[C@@H]4CCO)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C31H39FN6O3/c1-19-5-9-31(27-22(19)3-4-25(34)23(27)15-33)14-26-24(17-41-31)28(38-11-6-21(38)7-12-39)36-29(35-26)40-18-30-8-2-10-37(30)16-20(32)13-30/h3-4,19-21,39H,2,5-14,16-18,34H2,1H3	ARBVWVRPIMHVPL-UHFFFAOYSA-N	437135	US20260022132, Compound 741b	GTPase KRas [G12V]	Homo sapiens			 7.40						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437135	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437135&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493635	439658764							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212430	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC(CCC#N)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H38FN7O2/c1-20-7-9-32(28-23(20)5-6-26(36)24(28)14-35)13-27-25(18-42-32)29(39-15-21(16-39)4-2-10-34)38-30(37-27)41-19-31-8-3-11-40(31)17-22(33)12-31/h5-6,20-22H,2-4,7-9,11-13,15-19,36H2,1H3	PBWAIOOZXHTWHX-UHFFFAOYSA-N	437136	US20260022132, Compound 742a	GTPase KRas [G12V]	Homo sapiens			 140						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437136	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437136&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134494095	439658765							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212431	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC(C(C)(C)O)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H41FN6O3/c1-19-7-9-32(27-22(19)5-6-25(35)23(27)13-34)12-26-24(17-42-32)28(38-14-20(15-38)30(2,3)40)37-29(36-26)41-18-31-8-4-10-39(31)16-21(33)11-31/h5-6,19-21,40H,4,7-12,14-18,35H2,1-3H3	WSLXZJKHYQVJBP-UHFFFAOYSA-N	437137	US20260022132, Compound 743a	GTPase KRas [G12V]	Homo sapiens			>500						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437137	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437137&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493945	439658766							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212432	C[C@H](O)C1CN(c2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc3c2CO[C@@]2(CC[C@H](C)c4ccc(N)c(C#N)c42)C3)C1	InChI=1S/C31H39FN6O3/c1-18-6-8-31(27-22(18)4-5-25(34)23(27)12-33)11-26-24(16-41-31)28(37-13-20(14-37)19(2)39)36-29(35-26)40-17-30-7-3-9-38(30)15-21(32)10-30/h4-5,18-21,39H,3,6-11,13-17,34H2,1-2H3	WCRAATVQWLEXOF-UHFFFAOYSA-N	437140	US20260022132, Compound 745b	GTPase KRas [G12V]	Homo sapiens			 660						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437140	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437140&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493861	439658769							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212433	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC[C@]45C[C@@H](O)C5)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H39FN6O3/c1-19-5-7-32(27-22(19)3-4-25(35)23(27)15-34)14-26-24(17-42-32)28(39-10-8-30(39)12-21(40)13-30)37-29(36-26)41-18-31-6-2-9-38(31)16-20(33)11-31/h3-4,19-21,40H,2,5-14,16-18,35H2,1H3	PRTVPVSGMHPKLJ-UHFFFAOYSA-N	437142	US20260022132, Compound 747a	GTPase KRas [G12V]	Homo sapiens			 0.330						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437142	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437142&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493964	439658771							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212434	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCC45CC(O)C5)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H39FN6O3/c1-19-5-7-32(27-22(19)3-4-25(35)23(27)15-34)14-26-24(17-42-32)28(39-10-8-30(39)12-21(40)13-30)37-29(36-26)41-18-31-6-2-9-38(31)16-20(33)11-31/h3-4,19-21,40H,2,5-14,16-18,35H2,1H3	PRTVPVSGMHPKLJ-UHFFFAOYSA-N	437143	US20260022132, Compound 747b	GTPase KRas [G12V]	Homo sapiens			 0.260						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437143	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437143&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134494110	439658772							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212435	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC(n5cccn5)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H37FN8O2/c1-20-6-8-32(28-23(20)4-5-26(35)24(28)14-34)13-27-25(18-43-32)29(39-16-22(17-39)41-11-3-9-36-41)38-30(37-27)42-19-31-7-2-10-40(31)15-21(33)12-31/h3-5,9,11,20-22H,2,6-8,10,12-13,15-19,35H2,1H3	BQXHHGVZKFNJAP-UHFFFAOYSA-N	437144	US20260022132, Compound 748a	GTPase KRas [G12V]	Homo sapiens			 120						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437144	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437144&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493941	439658773							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212436	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC(F)(CC#N)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C31H35F2N7O2/c1-19-5-7-31(26-21(19)3-4-24(36)22(26)13-35)12-25-23(15-42-31)27(39-16-29(33,17-39)8-9-34)38-28(37-25)41-18-30-6-2-10-40(30)14-20(32)11-30/h3-4,19-20H,2,5-8,10-12,14-18,36H2,1H3	LUPWLXOBPYQFGM-UHFFFAOYSA-N	437145	US20260022132, Compound 749a	GTPase KRas [G12V]	Homo sapiens			 130						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437145	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437145&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493827	439658774							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212437	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC(n5ccnc5)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H37FN8O2/c1-20-5-7-32(28-23(20)3-4-26(35)24(28)13-34)12-27-25(17-43-32)29(40-15-22(16-40)39-10-8-36-19-39)38-30(37-27)42-18-31-6-2-9-41(31)14-21(33)11-31/h3-4,8,10,19-22H,2,5-7,9,11-12,14-18,35H2,1H3	MDPVZAZVSZRZJO-UHFFFAOYSA-N	437146	US20260022132, Compound 750a	GTPase KRas [G12V]	Homo sapiens			 0.420						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437146	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437146&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493647	439658775							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212438	N#Cc1c(N)ccc2c1[C@]1(CCC2)Cc2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc(N3CC[C@@H]3CO)c2CO1	InChI=1S/C29H35FN6O3/c30-19-11-28(7-2-9-35(28)14-19)17-38-27-33-24-12-29(8-1-3-18-4-5-23(32)21(13-31)25(18)29)39-16-22(24)26(34-27)36-10-6-20(36)15-37/h4-5,19-20,37H,1-3,6-12,14-17,32H2	BDPDXXCXPPFHGP-UHFFFAOYSA-N	437147	(S)-7-amino-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-4'-((R)-2-(hydroxymethyl)azetidin-1-yl)-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidine]-8-carbonitrile ::US20260022132, Compound 751a	GTPase KRas [G12V]	Homo sapiens			 2.40						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437147	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437147&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493962	439658776							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212439	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC5(CN(C)CCO5)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C33H42FN7O3/c1-21-6-8-33(28-23(21)4-5-26(36)24(28)14-35)13-27-25(16-44-33)29(40-18-32(19-40)17-39(2)10-11-43-32)38-30(37-27)42-20-31-7-3-9-41(31)15-22(34)12-31/h4-5,21-22H,3,6-13,15-20,36H2,1-2H3	TYVQDYPNZUUTDZ-UHFFFAOYSA-N	437148	US20260022132, Compound 752a	GTPase KRas [G12V]	Homo sapiens			>500						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437148	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437148&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493832	439658777							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212440	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC(O)C45CCC5)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H39FN6O3/c1-19-6-10-32(27-21(19)4-5-24(35)22(27)14-34)13-25-23(17-42-32)28(39-16-26(40)31(39)8-2-9-31)37-29(36-25)41-18-30-7-3-11-38(30)15-20(33)12-30/h4-5,19-20,26,40H,2-3,6-13,15-18,35H2,1H3	AEKKZDRXZWGXLU-UHFFFAOYSA-N	437149	US20260022132, Compound 753a	GTPase KRas [G12V]	Homo sapiens			 84.0						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437149	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437149&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134493820	439658778							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
212441	C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CC(OC5CC5)C4)c3CO2)c2c1ccc(N)c2C#N	InChI=1S/C32H39FN6O3/c1-19-7-9-32(28-23(19)5-6-26(35)24(28)13-34)12-27-25(17-41-32)29(38-15-22(16-38)42-21-3-4-21)37-30(36-27)40-18-31-8-2-10-39(31)14-20(33)11-31/h5-6,19-22H,2-4,7-12,14-18,35H2,1H3	JHUGBHLFEKUJIY-UHFFFAOYSA-N	437156	US20260022132, Compound 754a	GTPase KRas [G12V]	Homo sapiens			 46.0						US Patent		10.7270/Q2MW2NZB			US20260022132	Cabral, S; Mascitti, V; Decultot, LJ; Herold, J; Hesp, KD; Lajiness, JP; Seim, AE; Tofoleanu, F; Tsai, A	1/22/2026	6/3/2026	Treeline Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437156	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1398&target=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437156&enzyme=GTPase+KRas+%5BG12V%5D&column=ki&startPg=0&Increment=50&submit=Search			134494073	439658785							1	MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM	8PI0,7NY8,6YXW,6MQN,5V9O,5V9L,5V71,5KYK,5VQ0,5VPZ,5VPY,5VPI,5VP7,6GJ8,9C41,9PVF,5UK9,5UFE,6YR8,6WS4,9C43,5UFQ,7ROV,9C3Q,7RP3,8STN,6P0Z,5WHE,5WHD,7F0W,7EYX,9C3R,7XKJ,9RKC,9P45,9P44,9GBJ,9C40,8AZY,6ZL5,6GJ5,4EPR,6M9W,8AFC,9BG5,9U99,9U90,9U8Z,9U8U,8FMK,8FMJ,11QE,8EPW,8EBZ,7KFZ,6XGV,6OB3,9UOH,8X6R,8V3A,8V39,8QUG,8AZX,8AFB,7YCE,7YCC,9E9I	GTPase KRas	RASK_HUMAN	P01116	A8K8Z5 B0LPF9 P01118 Q96D10		small monomeric GTPase	L7RSL8_HUMAN	L7RSL8