BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Date of publication Date in BindingDB Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID PubChem SID ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence 1 PDB ID(s) of Target Chain 1 UniProt (SwissProt) Recommended Name of Target Chain 1 UniProt (SwissProt) Entry Name of Target Chain 1 UniProt (SwissProt) Primary ID of Target Chain 1 UniProt (SwissProt) Secondary ID(s) of Target Chain 1 UniProt (SwissProt) Alternative ID(s) of Target Chain 1 UniProt (TrEMBL) Submitted Name of Target Chain 1 UniProt (TrEMBL) Entry Name of Target Chain 1 UniProt (TrEMBL) Primary ID of Target Chain 1 UniProt (TrEMBL) Secondary ID(s) of Target Chain 1 UniProt (TrEMBL) Alternative ID(s) of Target Chain 1 BindingDB Target Chain Sequence 2 PDB ID(s) of Target Chain 2 UniProt (SwissProt) Recommended Name of Target Chain 2 UniProt (SwissProt) Entry Name of Target Chain 2 UniProt (SwissProt) Primary ID of Target Chain 2 UniProt (SwissProt) Secondary ID(s) of Target Chain 2 UniProt (SwissProt) Alternative ID(s) of Target Chain 2 UniProt (TrEMBL) Submitted Name of Target Chain 2 UniProt (TrEMBL) Entry Name of Target Chain 2 UniProt (TrEMBL) Primary ID of Target Chain 2 UniProt (TrEMBL) Secondary ID(s) of Target Chain 2 UniProt (TrEMBL) Alternative ID(s) of Target Chain 2 BindingDB Target Chain Sequence 3 PDB ID(s) of Target Chain 3 UniProt (SwissProt) Recommended Name of Target Chain 3 UniProt (SwissProt) Entry Name of Target Chain 3 UniProt (SwissProt) Primary ID of Target Chain 3 UniProt (SwissProt) Secondary ID(s) of Target Chain 3 UniProt (SwissProt) Alternative ID(s) of Target Chain 3 UniProt (TrEMBL) Submitted Name of Target Chain 3 UniProt (TrEMBL) Entry Name of Target Chain 3 UniProt (TrEMBL) Primary ID of Target Chain 3 UniProt (TrEMBL) Secondary ID(s) of Target Chain 3 UniProt (TrEMBL) Alternative ID(s) of Target Chain 3 BindingDB Target Chain Sequence 4 PDB ID(s) of Target Chain 4 UniProt (SwissProt) Recommended Name of Target Chain 4 UniProt (SwissProt) Entry Name of Target Chain 4 UniProt (SwissProt) Primary ID of Target Chain 4 UniProt (SwissProt) Secondary ID(s) of Target Chain 4 UniProt (SwissProt) Alternative ID(s) of Target Chain 4 UniProt (TrEMBL) Submitted Name of Target Chain 4 UniProt (TrEMBL) Entry Name of Target Chain 4 UniProt (TrEMBL) Primary ID of Target Chain 4 UniProt (TrEMBL) Secondary ID(s) of Target Chain 4 UniProt (TrEMBL) Alternative ID(s) of Target Chain 4 BindingDB Target Chain Sequence 5 PDB ID(s) of Target Chain 5 UniProt (SwissProt) Recommended Name of Target Chain 5 UniProt (SwissProt) Entry Name of Target Chain 5 UniProt (SwissProt) Primary ID of Target Chain 5 UniProt (SwissProt) Secondary ID(s) of Target Chain 5 UniProt (SwissProt) Alternative ID(s) of Target Chain 5 UniProt (TrEMBL) Submitted Name of Target Chain 5 UniProt (TrEMBL) Entry Name of Target Chain 5 UniProt (TrEMBL) Primary ID of Target Chain 5 UniProt (TrEMBL) Secondary ID(s) of Target Chain 5 UniProt (TrEMBL) Alternative ID(s) of Target Chain 5 BindingDB Target Chain Sequence 6 PDB ID(s) of Target Chain 6 UniProt (SwissProt) Recommended Name of Target Chain 6 UniProt (SwissProt) Entry Name of Target Chain 6 UniProt (SwissProt) Primary ID of Target Chain 6 UniProt (SwissProt) Secondary ID(s) of Target Chain 6 UniProt (SwissProt) Alternative ID(s) of Target Chain 6 UniProt (TrEMBL) Submitted Name of Target Chain 6 UniProt (TrEMBL) Entry Name of Target Chain 6 UniProt (TrEMBL) Primary ID of Target Chain 6 UniProt (TrEMBL) Secondary ID(s) of Target Chain 6 UniProt (TrEMBL) Alternative ID(s) of Target Chain 6 BindingDB Target Chain Sequence 7 PDB ID(s) of Target Chain 7 UniProt (SwissProt) Recommended Name of Target Chain 7 UniProt (SwissProt) Entry Name of Target Chain 7 UniProt (SwissProt) Primary ID of Target Chain 7 UniProt (SwissProt) Secondary ID(s) of Target Chain 7 UniProt (SwissProt) Alternative ID(s) of Target Chain 7 UniProt (TrEMBL) Submitted Name of Target Chain 7 UniProt (TrEMBL) Entry Name of Target Chain 7 UniProt (TrEMBL) Primary ID of Target Chain 7 UniProt (TrEMBL) Secondary ID(s) of Target Chain 7 UniProt (TrEMBL) Alternative ID(s) of Target Chain 7 BindingDB Target Chain Sequence 8 PDB ID(s) of Target Chain 8 UniProt (SwissProt) Recommended Name of Target Chain 8 UniProt (SwissProt) Entry Name of Target Chain 8 UniProt (SwissProt) Primary ID of Target Chain 8 UniProt (SwissProt) Secondary ID(s) of Target Chain 8 UniProt (SwissProt) Alternative ID(s) of Target Chain 8 UniProt (TrEMBL) Submitted Name of Target Chain 8 UniProt (TrEMBL) Entry Name of Target Chain 8 UniProt (TrEMBL) Primary ID of Target Chain 8 UniProt (TrEMBL) Secondary ID(s) of Target Chain 8 UniProt (TrEMBL) Alternative ID(s) of Target Chain 8 BindingDB Target Chain Sequence 9 PDB ID(s) of Target Chain 9 UniProt (SwissProt) Recommended Name of Target Chain 9 UniProt (SwissProt) Entry Name of Target Chain 9 UniProt (SwissProt) Primary ID of Target Chain 9 UniProt (SwissProt) Secondary ID(s) of Target Chain 9 UniProt (SwissProt) Alternative ID(s) of Target Chain 9 UniProt (TrEMBL) Submitted Name of Target Chain 9 UniProt (TrEMBL) Entry Name of Target Chain 9 UniProt (TrEMBL) Primary ID of Target Chain 9 UniProt (TrEMBL) Secondary ID(s) of Target Chain 9 UniProt (TrEMBL) Alternative ID(s) of Target Chain 9 BindingDB Target Chain Sequence 10 PDB ID(s) of Target Chain 10 UniProt (SwissProt) Recommended Name of Target Chain 10 UniProt (SwissProt) Entry Name of Target Chain 10 UniProt (SwissProt) Primary ID of Target Chain 10 UniProt (SwissProt) Secondary ID(s) of Target Chain 10 UniProt (SwissProt) Alternative ID(s) of Target Chain 10 UniProt (TrEMBL) Submitted Name of Target Chain 10 UniProt (TrEMBL) Entry Name of Target Chain 10 UniProt (TrEMBL) Primary ID of Target Chain 10 UniProt (TrEMBL) Secondary ID(s) of Target Chain 10 UniProt (TrEMBL) Alternative ID(s) of Target Chain 10 BindingDB Target Chain Sequence 11 PDB ID(s) of Target Chain 11 UniProt (SwissProt) Recommended Name of Target Chain 11 UniProt (SwissProt) Entry Name of Target Chain 11 UniProt (SwissProt) Primary ID of Target Chain 11 UniProt (SwissProt) Secondary ID(s) of Target Chain 11 UniProt (SwissProt) Alternative ID(s) of Target Chain 11 UniProt (TrEMBL) Submitted Name of Target Chain 11 UniProt (TrEMBL) Entry Name of Target Chain 11 UniProt (TrEMBL) Primary ID of Target Chain 11 UniProt (TrEMBL) Secondary ID(s) of Target Chain 11 UniProt (TrEMBL) Alternative ID(s) of Target Chain 11 BindingDB Target Chain Sequence 12 PDB ID(s) of Target Chain 12 UniProt (SwissProt) Recommended Name of Target Chain 12 UniProt (SwissProt) Entry Name of Target Chain 12 UniProt (SwissProt) Primary ID of Target Chain 12 UniProt (SwissProt) Secondary ID(s) of Target Chain 12 UniProt (SwissProt) Alternative ID(s) of Target Chain 12 UniProt (TrEMBL) Submitted Name of Target Chain 12 UniProt (TrEMBL) Entry Name of Target Chain 12 UniProt (TrEMBL) Primary ID of Target Chain 12 UniProt (TrEMBL) Secondary ID(s) of Target Chain 12 UniProt (TrEMBL) Alternative ID(s) of Target Chain 12 BindingDB Target Chain Sequence 13 PDB ID(s) of Target Chain 13 UniProt (SwissProt) Recommended Name of Target Chain 13 UniProt (SwissProt) Entry Name of Target Chain 13 UniProt (SwissProt) Primary ID of Target Chain 13 UniProt (SwissProt) Secondary ID(s) of Target Chain 13 UniProt (SwissProt) Alternative ID(s) of Target Chain 13 UniProt (TrEMBL) Submitted Name of Target Chain 13 UniProt (TrEMBL) Entry Name of Target Chain 13 UniProt (TrEMBL) Primary ID of Target Chain 13 UniProt (TrEMBL) Secondary ID(s) of Target Chain 13 UniProt (TrEMBL) Alternative ID(s) of Target Chain 13 BindingDB Target Chain Sequence 14 PDB ID(s) of Target Chain 14 UniProt (SwissProt) Recommended Name of Target Chain 14 UniProt (SwissProt) Entry Name of Target Chain 14 UniProt (SwissProt) Primary ID of Target Chain 14 UniProt (SwissProt) Secondary ID(s) of Target Chain 14 UniProt (SwissProt) Alternative ID(s) of Target Chain 14 UniProt (TrEMBL) Submitted Name of Target Chain 14 UniProt (TrEMBL) Entry Name of Target Chain 14 UniProt (TrEMBL) Primary ID of Target Chain 14 UniProt (TrEMBL) Secondary ID(s) of Target Chain 14 UniProt (TrEMBL) Alternative ID(s) of Target Chain 14 BindingDB Target Chain Sequence 15 PDB ID(s) of Target Chain 15 UniProt (SwissProt) Recommended Name of Target Chain 15 UniProt (SwissProt) Entry Name of Target Chain 15 UniProt (SwissProt) Primary ID of Target Chain 15 UniProt (SwissProt) Secondary ID(s) of Target Chain 15 UniProt (SwissProt) Alternative ID(s) of Target Chain 15 UniProt (TrEMBL) Submitted Name of Target Chain 15 UniProt (TrEMBL) Entry Name of Target Chain 15 UniProt (TrEMBL) Primary ID of Target Chain 15 UniProt (TrEMBL) Secondary ID(s) of Target Chain 15 UniProt (TrEMBL) Alternative ID(s) of Target Chain 15 BindingDB Target Chain Sequence 16 PDB ID(s) of Target Chain 16 UniProt (SwissProt) Recommended Name of Target Chain 16 UniProt (SwissProt) Entry Name of Target Chain 16 UniProt (SwissProt) Primary ID of Target Chain 16 UniProt (SwissProt) Secondary ID(s) of Target Chain 16 UniProt (SwissProt) Alternative ID(s) of Target Chain 16 UniProt (TrEMBL) Submitted Name of Target Chain 16 UniProt (TrEMBL) Entry Name of Target Chain 16 UniProt (TrEMBL) Primary ID of Target Chain 16 UniProt (TrEMBL) Secondary ID(s) of Target Chain 16 UniProt (TrEMBL) Alternative ID(s) of Target Chain 16 BindingDB Target Chain Sequence 17 PDB ID(s) of Target Chain 17 UniProt (SwissProt) Recommended Name of Target Chain 17 UniProt (SwissProt) Entry Name of Target Chain 17 UniProt (SwissProt) Primary ID of Target Chain 17 UniProt (SwissProt) Secondary ID(s) of Target Chain 17 UniProt (SwissProt) Alternative ID(s) of Target Chain 17 UniProt (TrEMBL) Submitted Name of Target Chain 17 UniProt (TrEMBL) Entry Name of Target Chain 17 UniProt (TrEMBL) Primary ID of Target Chain 17 UniProt (TrEMBL) Secondary ID(s) of Target Chain 17 UniProt (TrEMBL) Alternative ID(s) of Target Chain 17 BindingDB Target Chain Sequence 18 PDB ID(s) of Target Chain 18 UniProt (SwissProt) Recommended Name of Target Chain 18 UniProt (SwissProt) Entry Name of Target Chain 18 UniProt (SwissProt) Primary ID of Target Chain 18 UniProt (SwissProt) Secondary ID(s) of Target Chain 18 UniProt (SwissProt) Alternative ID(s) of Target Chain 18 UniProt (TrEMBL) Submitted Name of Target Chain 18 UniProt (TrEMBL) Entry Name of Target Chain 18 UniProt (TrEMBL) Primary ID of Target Chain 18 UniProt (TrEMBL) Secondary ID(s) of Target Chain 18 UniProt (TrEMBL) Alternative ID(s) of Target Chain 18 BindingDB Target Chain Sequence 19 PDB ID(s) of Target Chain 19 UniProt (SwissProt) Recommended Name of Target Chain 19 UniProt (SwissProt) Entry Name of Target Chain 19 UniProt (SwissProt) Primary ID of Target Chain 19 UniProt (SwissProt) Secondary ID(s) of Target Chain 19 UniProt (SwissProt) Alternative ID(s) of Target Chain 19 UniProt (TrEMBL) Submitted Name of Target Chain 19 UniProt (TrEMBL) Entry Name of Target Chain 19 UniProt (TrEMBL) Primary ID of Target Chain 19 UniProt (TrEMBL) Secondary ID(s) of Target Chain 19 UniProt (TrEMBL) Alternative ID(s) of Target Chain 19 BindingDB Target Chain Sequence 20 PDB ID(s) of Target Chain 20 UniProt (SwissProt) Recommended Name of Target Chain 20 UniProt (SwissProt) Entry Name of Target Chain 20 UniProt (SwissProt) Primary ID of Target Chain 20 UniProt (SwissProt) Secondary ID(s) of Target Chain 20 UniProt (SwissProt) Alternative ID(s) of Target Chain 20 UniProt (TrEMBL) Submitted Name of Target Chain 20 UniProt (TrEMBL) Entry Name of Target Chain 20 UniProt (TrEMBL) Primary ID of Target Chain 20 UniProt (TrEMBL) Secondary ID(s) of Target Chain 20 UniProt (TrEMBL) Alternative ID(s) of Target Chain 20 BindingDB Target Chain Sequence 21 PDB ID(s) of Target Chain 21 UniProt (SwissProt) Recommended Name of Target Chain 21 UniProt (SwissProt) Entry Name of Target Chain 21 UniProt (SwissProt) Primary ID of Target Chain 21 UniProt (SwissProt) Secondary ID(s) of Target Chain 21 UniProt (SwissProt) Alternative ID(s) of Target Chain 21 UniProt (TrEMBL) Submitted Name of Target Chain 21 UniProt (TrEMBL) Entry Name of Target Chain 21 UniProt (TrEMBL) Primary ID of Target Chain 21 UniProt (TrEMBL) Secondary ID(s) of Target Chain 21 UniProt (TrEMBL) Alternative ID(s) of Target Chain 21 BindingDB Target Chain Sequence 22 PDB ID(s) of Target Chain 22 UniProt (SwissProt) Recommended Name of Target Chain 22 UniProt (SwissProt) Entry Name of Target Chain 22 UniProt (SwissProt) Primary ID of Target Chain 22 UniProt (SwissProt) Secondary ID(s) of Target Chain 22 UniProt (SwissProt) Alternative ID(s) of Target Chain 22 UniProt (TrEMBL) Submitted Name of Target Chain 22 UniProt (TrEMBL) Entry Name of Target Chain 22 UniProt (TrEMBL) Primary ID of Target Chain 22 UniProt (TrEMBL) Secondary ID(s) of Target Chain 22 UniProt (TrEMBL) Alternative ID(s) of Target Chain 22 BindingDB Target Chain Sequence 23 PDB ID(s) of Target Chain 23 UniProt (SwissProt) Recommended Name of Target Chain 23 UniProt (SwissProt) Entry Name of Target Chain 23 UniProt (SwissProt) Primary ID of Target Chain 23 UniProt (SwissProt) Secondary ID(s) of Target Chain 23 UniProt (SwissProt) Alternative ID(s) of Target Chain 23 UniProt (TrEMBL) Submitted Name of Target Chain 23 UniProt (TrEMBL) Entry Name of Target Chain 23 UniProt (TrEMBL) Primary ID of Target Chain 23 UniProt (TrEMBL) Secondary ID(s) of Target Chain 23 UniProt (TrEMBL) Alternative ID(s) of Target Chain 23 BindingDB Target Chain Sequence 24 PDB ID(s) of Target Chain 24 UniProt (SwissProt) Recommended Name of Target Chain 24 UniProt (SwissProt) Entry Name of Target Chain 24 UniProt (SwissProt) Primary ID of Target Chain 24 UniProt (SwissProt) Secondary ID(s) of Target Chain 24 UniProt (SwissProt) Alternative ID(s) of Target Chain 24 UniProt (TrEMBL) Submitted Name of Target Chain 24 UniProt (TrEMBL) Entry Name of Target Chain 24 UniProt (TrEMBL) Primary ID of Target Chain 24 UniProt (TrEMBL) Secondary ID(s) of Target Chain 24 UniProt (TrEMBL) Alternative ID(s) of Target Chain 24 BindingDB Target Chain Sequence 25 PDB ID(s) of Target Chain 25 UniProt (SwissProt) Recommended Name of Target Chain 25 UniProt (SwissProt) Entry Name of Target Chain 25 UniProt (SwissProt) Primary ID of Target Chain 25 UniProt (SwissProt) Secondary ID(s) of Target Chain 25 UniProt (SwissProt) Alternative ID(s) of Target Chain 25 UniProt (TrEMBL) Submitted Name of Target Chain 25 UniProt (TrEMBL) Entry Name of Target Chain 25 UniProt (TrEMBL) Primary ID of Target Chain 25 UniProt (TrEMBL) Secondary ID(s) of Target Chain 25 UniProt (TrEMBL) Alternative ID(s) of Target Chain 25 BindingDB Target Chain Sequence 26 PDB ID(s) of Target Chain 26 UniProt (SwissProt) Recommended Name of Target Chain 26 UniProt (SwissProt) Entry Name of Target Chain 26 UniProt (SwissProt) Primary ID of Target Chain 26 UniProt (SwissProt) Secondary ID(s) of Target Chain 26 UniProt (SwissProt) Alternative ID(s) of Target Chain 26 UniProt (TrEMBL) Submitted Name of Target Chain 26 UniProt (TrEMBL) Entry Name of Target Chain 26 UniProt (TrEMBL) Primary ID of Target Chain 26 UniProt (TrEMBL) Secondary ID(s) of Target Chain 26 UniProt (TrEMBL) Alternative ID(s) of Target Chain 26 BindingDB Target Chain Sequence 27 PDB ID(s) of Target Chain 27 UniProt (SwissProt) Recommended Name of Target Chain 27 UniProt (SwissProt) Entry Name of Target Chain 27 UniProt (SwissProt) Primary ID of Target Chain 27 UniProt (SwissProt) Secondary ID(s) of Target Chain 27 UniProt (SwissProt) Alternative ID(s) of Target Chain 27 UniProt (TrEMBL) Submitted Name of Target Chain 27 UniProt (TrEMBL) Entry Name of Target Chain 27 UniProt (TrEMBL) Primary ID of Target Chain 27 UniProt (TrEMBL) Secondary ID(s) of Target Chain 27 UniProt (TrEMBL) Alternative ID(s) of Target Chain 27 BindingDB Target Chain Sequence 28 PDB ID(s) of Target Chain 28 UniProt (SwissProt) Recommended Name of Target Chain 28 UniProt (SwissProt) Entry Name of Target Chain 28 UniProt (SwissProt) Primary ID of Target Chain 28 UniProt (SwissProt) Secondary ID(s) of Target Chain 28 UniProt (SwissProt) Alternative ID(s) of Target Chain 28 UniProt (TrEMBL) Submitted Name of Target Chain 28 UniProt (TrEMBL) Entry Name of Target Chain 28 UniProt (TrEMBL) Primary ID of Target Chain 28 UniProt (TrEMBL) Secondary ID(s) of Target Chain 28 UniProt (TrEMBL) Alternative ID(s) of Target Chain 28 BindingDB Target Chain Sequence 29 PDB ID(s) of Target Chain 29 UniProt (SwissProt) Recommended Name of Target Chain 29 UniProt (SwissProt) Entry Name of Target Chain 29 UniProt (SwissProt) Primary ID of Target Chain 29 UniProt (SwissProt) Secondary ID(s) of Target Chain 29 UniProt (SwissProt) Alternative ID(s) of Target Chain 29 UniProt (TrEMBL) Submitted Name of Target Chain 29 UniProt (TrEMBL) Entry Name of Target Chain 29 UniProt (TrEMBL) Primary ID of Target Chain 29 UniProt (TrEMBL) Secondary ID(s) of Target Chain 29 UniProt (TrEMBL) Alternative ID(s) of Target Chain 29 BindingDB Target Chain Sequence 30 PDB ID(s) of Target Chain 30 UniProt (SwissProt) Recommended Name of Target Chain 30 UniProt (SwissProt) Entry Name of Target Chain 30 UniProt (SwissProt) Primary ID of Target Chain 30 UniProt (SwissProt) Secondary ID(s) of Target Chain 30 UniProt (SwissProt) Alternative ID(s) of Target Chain 30 UniProt (TrEMBL) Submitted Name of Target Chain 30 UniProt (TrEMBL) Entry Name of Target Chain 30 UniProt (TrEMBL) Primary ID of Target Chain 30 UniProt (TrEMBL) Secondary ID(s) of Target Chain 30 UniProt (TrEMBL) Alternative ID(s) of Target Chain 30 BindingDB Target Chain Sequence 31 PDB ID(s) of Target Chain 31 UniProt (SwissProt) Recommended Name of Target Chain 31 UniProt (SwissProt) Entry Name of Target Chain 31 UniProt (SwissProt) Primary ID of Target Chain 31 UniProt (SwissProt) Secondary ID(s) of Target Chain 31 UniProt (SwissProt) Alternative ID(s) of Target Chain 31 UniProt (TrEMBL) Submitted Name of Target Chain 31 UniProt (TrEMBL) Entry Name of Target Chain 31 UniProt (TrEMBL) Primary ID of Target Chain 31 UniProt (TrEMBL) Secondary ID(s) of Target Chain 31 UniProt (TrEMBL) Alternative ID(s) of Target Chain 31 BindingDB Target Chain Sequence 32 PDB ID(s) of Target Chain 32 UniProt (SwissProt) Recommended Name of Target Chain 32 UniProt (SwissProt) Entry Name of Target Chain 32 UniProt (SwissProt) Primary ID of Target Chain 32 UniProt (SwissProt) Secondary ID(s) of Target Chain 32 UniProt (SwissProt) Alternative ID(s) of Target Chain 32 UniProt (TrEMBL) Submitted Name of Target Chain 32 UniProt (TrEMBL) Entry Name of Target Chain 32 UniProt (TrEMBL) Primary ID of Target Chain 32 UniProt (TrEMBL) Secondary ID(s) of Target Chain 32 UniProt (TrEMBL) Alternative ID(s) of Target Chain 32 BindingDB Target Chain Sequence 33 PDB ID(s) of Target Chain 33 UniProt (SwissProt) Recommended Name of Target Chain 33 UniProt (SwissProt) Entry Name of Target Chain 33 UniProt (SwissProt) Primary ID of Target Chain 33 UniProt (SwissProt) Secondary ID(s) of Target Chain 33 UniProt (SwissProt) Alternative ID(s) of Target Chain 33 UniProt (TrEMBL) Submitted Name of Target Chain 33 UniProt (TrEMBL) Entry Name of Target Chain 33 UniProt (TrEMBL) Primary ID of Target Chain 33 UniProt (TrEMBL) Secondary ID(s) of Target Chain 33 UniProt (TrEMBL) Alternative ID(s) of Target Chain 33 BindingDB Target Chain Sequence 34 PDB ID(s) of Target Chain 34 UniProt (SwissProt) Recommended Name of Target Chain 34 UniProt (SwissProt) Entry Name of Target Chain 34 UniProt (SwissProt) Primary ID of Target Chain 34 UniProt (SwissProt) Secondary ID(s) of Target Chain 34 UniProt (SwissProt) Alternative ID(s) of Target Chain 34 UniProt (TrEMBL) Submitted Name of Target Chain 34 UniProt (TrEMBL) Entry Name of Target Chain 34 UniProt (TrEMBL) Primary ID of Target Chain 34 UniProt (TrEMBL) Secondary ID(s) of Target Chain 34 UniProt (TrEMBL) Alternative ID(s) of Target Chain 34 BindingDB Target Chain Sequence 35 PDB ID(s) of Target Chain 35 UniProt (SwissProt) Recommended Name of Target Chain 35 UniProt (SwissProt) Entry Name of Target Chain 35 UniProt (SwissProt) Primary ID of Target Chain 35 UniProt (SwissProt) Secondary ID(s) of Target Chain 35 UniProt (SwissProt) Alternative ID(s) of Target Chain 35 UniProt (TrEMBL) Submitted Name of Target Chain 35 UniProt (TrEMBL) Entry Name of Target Chain 35 UniProt (TrEMBL) Primary ID of Target Chain 35 UniProt (TrEMBL) Secondary ID(s) of Target Chain 35 UniProt (TrEMBL) Alternative ID(s) of Target Chain 35 BindingDB Target Chain Sequence 36 PDB ID(s) of Target Chain 36 UniProt (SwissProt) Recommended Name of Target Chain 36 UniProt (SwissProt) Entry Name of Target Chain 36 UniProt (SwissProt) Primary ID of Target Chain 36 UniProt (SwissProt) Secondary ID(s) of Target Chain 36 UniProt (SwissProt) Alternative ID(s) of Target Chain 36 UniProt (TrEMBL) Submitted Name of Target Chain 36 UniProt (TrEMBL) Entry Name of Target Chain 36 UniProt (TrEMBL) Primary ID of Target Chain 36 UniProt (TrEMBL) Secondary ID(s) of Target Chain 36 UniProt (TrEMBL) Alternative ID(s) of Target Chain 36 BindingDB Target Chain Sequence 37 PDB ID(s) of Target Chain 37 UniProt (SwissProt) Recommended Name of Target Chain 37 UniProt (SwissProt) Entry Name of Target Chain 37 UniProt (SwissProt) Primary ID of Target Chain 37 UniProt (SwissProt) Secondary ID(s) of Target Chain 37 UniProt (SwissProt) Alternative ID(s) of Target Chain 37 UniProt (TrEMBL) Submitted Name of Target Chain 37 UniProt (TrEMBL) Entry Name of Target Chain 37 UniProt (TrEMBL) Primary ID of Target Chain 37 UniProt (TrEMBL) Secondary ID(s) of Target Chain 37 UniProt (TrEMBL) Alternative ID(s) of Target Chain 37 BindingDB Target Chain Sequence 38 PDB ID(s) of Target Chain 38 UniProt (SwissProt) Recommended Name of Target Chain 38 UniProt (SwissProt) Entry Name of Target Chain 38 UniProt (SwissProt) Primary ID of Target Chain 38 UniProt (SwissProt) Secondary ID(s) of Target Chain 38 UniProt (SwissProt) Alternative ID(s) of Target Chain 38 UniProt (TrEMBL) Submitted Name of Target Chain 38 UniProt (TrEMBL) Entry Name of Target Chain 38 UniProt (TrEMBL) Primary ID of Target Chain 38 UniProt (TrEMBL) Secondary ID(s) of Target Chain 38 UniProt (TrEMBL) Alternative ID(s) of Target Chain 38 BindingDB Target Chain Sequence 39 PDB ID(s) of Target Chain 39 UniProt (SwissProt) Recommended Name of Target Chain 39 UniProt (SwissProt) Entry Name of Target Chain 39 UniProt (SwissProt) Primary ID of Target Chain 39 UniProt (SwissProt) Secondary ID(s) of Target Chain 39 UniProt (SwissProt) Alternative ID(s) of Target Chain 39 UniProt (TrEMBL) Submitted Name of Target Chain 39 UniProt (TrEMBL) Entry Name of Target Chain 39 UniProt (TrEMBL) Primary ID of Target Chain 39 UniProt (TrEMBL) Secondary ID(s) of Target Chain 39 UniProt (TrEMBL) Alternative ID(s) of Target Chain 39 BindingDB Target Chain Sequence 40 PDB ID(s) of Target Chain 40 UniProt (SwissProt) Recommended Name of Target Chain 40 UniProt (SwissProt) Entry Name of Target Chain 40 UniProt (SwissProt) Primary ID of Target Chain 40 UniProt (SwissProt) Secondary ID(s) of Target Chain 40 UniProt (SwissProt) Alternative ID(s) of Target Chain 40 UniProt (TrEMBL) Submitted Name of Target Chain 40 UniProt (TrEMBL) Entry Name of Target Chain 40 UniProt (TrEMBL) Primary ID of Target Chain 40 UniProt (TrEMBL) Secondary ID(s) of Target Chain 40 UniProt (TrEMBL) Alternative ID(s) of Target Chain 40 BindingDB Target Chain Sequence 41 PDB ID(s) of Target Chain 41 UniProt (SwissProt) Recommended Name of Target Chain 41 UniProt (SwissProt) Entry Name of Target Chain 41 UniProt (SwissProt) Primary ID of Target Chain 41 UniProt (SwissProt) Secondary ID(s) of Target Chain 41 UniProt (SwissProt) Alternative ID(s) of Target Chain 41 UniProt (TrEMBL) Submitted Name of Target Chain 41 UniProt (TrEMBL) Entry Name of Target Chain 41 UniProt (TrEMBL) Primary ID of Target Chain 41 UniProt (TrEMBL) Secondary ID(s) of Target Chain 41 UniProt (TrEMBL) Alternative ID(s) of Target Chain 41 BindingDB Target Chain Sequence 42 PDB ID(s) of Target Chain 42 UniProt (SwissProt) Recommended Name of Target Chain 42 UniProt (SwissProt) Entry Name of Target Chain 42 UniProt (SwissProt) Primary ID of Target Chain 42 UniProt (SwissProt) Secondary ID(s) of Target Chain 42 UniProt (SwissProt) Alternative ID(s) of Target Chain 42 UniProt (TrEMBL) Submitted Name of Target Chain 42 UniProt (TrEMBL) Entry Name of Target Chain 42 UniProt (TrEMBL) Primary ID of Target Chain 42 UniProt (TrEMBL) Secondary ID(s) of Target Chain 42 UniProt (TrEMBL) Alternative ID(s) of Target Chain 42 BindingDB Target Chain Sequence 43 PDB ID(s) of Target Chain 43 UniProt (SwissProt) Recommended Name of Target Chain 43 UniProt (SwissProt) Entry Name of Target Chain 43 UniProt (SwissProt) Primary ID of Target Chain 43 UniProt (SwissProt) Secondary ID(s) of Target Chain 43 UniProt (SwissProt) Alternative ID(s) of Target Chain 43 UniProt (TrEMBL) Submitted Name of Target Chain 43 UniProt (TrEMBL) Entry Name of Target Chain 43 UniProt (TrEMBL) Primary ID of Target Chain 43 UniProt (TrEMBL) Secondary ID(s) of Target Chain 43 UniProt (TrEMBL) Alternative ID(s) of Target Chain 43 BindingDB Target Chain Sequence 44 PDB ID(s) of Target Chain 44 UniProt (SwissProt) Recommended Name of Target Chain 44 UniProt (SwissProt) Entry Name of Target Chain 44 UniProt (SwissProt) Primary ID of Target Chain 44 UniProt (SwissProt) Secondary ID(s) of Target Chain 44 UniProt (SwissProt) Alternative ID(s) of Target Chain 44 UniProt (TrEMBL) Submitted Name of Target Chain 44 UniProt (TrEMBL) Entry Name of Target Chain 44 UniProt (TrEMBL) Primary ID of Target Chain 44 UniProt (TrEMBL) Secondary ID(s) of Target Chain 44 UniProt (TrEMBL) Alternative ID(s) of Target Chain 44 BindingDB Target Chain Sequence 45 PDB ID(s) of Target Chain 45 UniProt (SwissProt) Recommended Name of Target Chain 45 UniProt (SwissProt) Entry Name of Target Chain 45 UniProt (SwissProt) Primary ID of Target Chain 45 UniProt (SwissProt) Secondary ID(s) of Target Chain 45 UniProt (SwissProt) Alternative ID(s) of Target Chain 45 UniProt (TrEMBL) Submitted Name of Target Chain 45 UniProt (TrEMBL) Entry Name of Target Chain 45 UniProt (TrEMBL) Primary ID of Target Chain 45 UniProt (TrEMBL) Secondary ID(s) of Target Chain 45 UniProt (TrEMBL) Alternative ID(s) of Target Chain 45 BindingDB Target Chain Sequence 46 PDB ID(s) of Target Chain 46 UniProt (SwissProt) Recommended Name of Target Chain 46 UniProt (SwissProt) Entry Name of Target Chain 46 UniProt (SwissProt) Primary ID of Target Chain 46 UniProt (SwissProt) Secondary ID(s) of Target Chain 46 UniProt (SwissProt) Alternative ID(s) of Target Chain 46 UniProt (TrEMBL) Submitted Name of Target Chain 46 UniProt (TrEMBL) Entry Name of Target Chain 46 UniProt (TrEMBL) Primary ID of Target Chain 46 UniProt (TrEMBL) Secondary ID(s) of Target Chain 46 UniProt (TrEMBL) Alternative ID(s) of Target Chain 46 BindingDB Target Chain Sequence 47 PDB ID(s) of Target Chain 47 UniProt (SwissProt) Recommended Name of Target Chain 47 UniProt (SwissProt) Entry Name of Target Chain 47 UniProt (SwissProt) Primary ID of Target Chain 47 UniProt (SwissProt) Secondary ID(s) of Target Chain 47 UniProt (SwissProt) Alternative ID(s) of Target Chain 47 UniProt (TrEMBL) Submitted Name of Target Chain 47 UniProt (TrEMBL) Entry Name of Target Chain 47 UniProt (TrEMBL) Primary ID of Target Chain 47 UniProt (TrEMBL) Secondary ID(s) of Target Chain 47 UniProt (TrEMBL) Alternative ID(s) of Target Chain 47 BindingDB Target Chain Sequence 48 PDB ID(s) of Target Chain 48 UniProt (SwissProt) Recommended Name of Target Chain 48 UniProt (SwissProt) Entry Name of Target Chain 48 UniProt (SwissProt) Primary ID of Target Chain 48 UniProt (SwissProt) Secondary ID(s) of Target Chain 48 UniProt (SwissProt) Alternative ID(s) of Target Chain 48 UniProt (TrEMBL) Submitted Name of Target Chain 48 UniProt (TrEMBL) Entry Name of Target Chain 48 UniProt (TrEMBL) Primary ID of Target Chain 48 UniProt (TrEMBL) Secondary ID(s) of Target Chain 48 UniProt (TrEMBL) Alternative ID(s) of Target Chain 48 BindingDB Target Chain Sequence 49 PDB ID(s) of Target Chain 49 UniProt (SwissProt) Recommended Name of Target Chain 49 UniProt (SwissProt) Entry Name of Target Chain 49 UniProt (SwissProt) Primary ID of Target Chain 49 UniProt (SwissProt) Secondary ID(s) of Target Chain 49 UniProt (SwissProt) Alternative ID(s) of Target Chain 49 UniProt (TrEMBL) Submitted Name of Target Chain 49 UniProt (TrEMBL) Entry Name of Target Chain 49 UniProt (TrEMBL) Primary ID of Target Chain 49 UniProt (TrEMBL) Secondary ID(s) of Target Chain 49 UniProt (TrEMBL) Alternative ID(s) of Target Chain 49 BindingDB Target Chain Sequence 50 PDB ID(s) of Target Chain 50 UniProt (SwissProt) Recommended Name of Target Chain 50 UniProt (SwissProt) Entry Name of Target Chain 50 UniProt (SwissProt) Primary ID of Target Chain 50 UniProt (SwissProt) Secondary ID(s) of Target Chain 50 UniProt (SwissProt) Alternative ID(s) of Target Chain 50 UniProt (TrEMBL) Submitted Name of Target Chain 50 UniProt (TrEMBL) Entry Name of Target Chain 50 UniProt (TrEMBL) Primary ID of Target Chain 50 UniProt (TrEMBL) Secondary ID(s) of Target Chain 50 UniProt (TrEMBL) Alternative ID(s) of Target Chain 50 211110 C#Cc1c(F)ccc2cc(O)cc(-c3ncc4c(N5C6CCC5CNC6)nn(C)c4c3F)c12 InChI=1S/C25H21F2N5O/c1-3-17-20(26)7-4-13-8-16(33)9-18(21(13)17)23-22(27)24-19(12-29-23)25(30-31(24)2)32-14-5-6-15(32)11-28-10-14/h1,4,7-9,12,14-15,28,33H,5-6,10-11H2,2H3 PTFHATFTGVUEEB-UHFFFAOYSA-N 372324 US20260022118, Example 1 GTPase NRas [G12D] 499 US Patent 10.7270/Q2SN0FTF US20260022118 NAGY, E; MANDAL, PK; JONES, P; SOTH, MJ; CROSS, JB; REYNA, NJ; COX, J; MCAFOOS, TJ; TRAN, TN 1/22/2026 6/3/2026 University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372324 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2110&target=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372324&enzyme=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 132254819 402359265 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDLPTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKKLNSSDDGTQGCMGLPCVVM 8TBI,3CON,9P46,6MQT,6MQG,421P,821P,1PLL,1PLJ,1JAI,1CLU,8UN3,8UN5,7L0G,8TLR,1PLK,1JAH,4L9W,4L9S GTPase NRas RASN_HUMAN P01111 Q14971 Q15104 Q15282 211111 C#Cc1c(F)ccc2cc(O)cc(-c3ncc4c([C@H]5[C@@H]6CNC[C@@H]65)cn(C)c4c3F)c12 InChI=1S/C25H19F2N3O/c1-3-14-20(26)5-4-12-6-13(31)7-15(21(12)14)24-23(27)25-18(10-29-24)19(11-30(25)2)22-16-8-28-9-17(16)22/h1,4-7,10-11,16-17,22,28,31H,8-9H2,2H3 AJUNZAYEMMQVQR-UHFFFAOYSA-N 372326 US20260022118, Example 2 GTPase NRas [G12D] 52.6 US Patent 10.7270/Q2SN0FTF US20260022118 NAGY, E; MANDAL, PK; JONES, P; SOTH, MJ; CROSS, JB; REYNA, NJ; COX, J; MCAFOOS, TJ; TRAN, TN 1/22/2026 6/3/2026 University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372326 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2110&target=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372326&enzyme=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 132266625 402359267 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDLPTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKKLNSSDDGTQGCMGLPCVVM 8TBI,3CON,9P46,6MQT,6MQG,421P,821P,1PLL,1PLJ,1JAI,1CLU,8UN3,8UN5,7L0G,8TLR,1PLK,1JAH,4L9W,4L9S GTPase NRas RASN_HUMAN P01111 Q14971 Q15104 Q15282 211112 C#Cc1c(F)ccc2cc(O)cc(-c3ncc4c([C@H]5[C@@H]6CNC[C@@H]65)nn(C)c4c3F)c12 InChI=1S/C24H18F2N4O/c1-3-13-18(25)5-4-11-6-12(31)7-14(19(11)13)23-21(26)24-17(10-28-23)22(29-30(24)2)20-15-8-27-9-16(15)20/h1,4-7,10,15-16,20,27,31H,8-9H2,2H3 PEWKAELNLLCUBJ-UHFFFAOYSA-N 372327 US20260022118, Example 3 GTPase NRas [G12D] 85.0 US Patent 10.7270/Q2SN0FTF US20260022118 NAGY, E; MANDAL, PK; JONES, P; SOTH, MJ; CROSS, JB; REYNA, NJ; COX, J; MCAFOOS, TJ; TRAN, TN 1/22/2026 6/3/2026 University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372327 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2110&target=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372327&enzyme=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 132254745 402359268 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDLPTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKKLNSSDDGTQGCMGLPCVVM 8TBI,3CON,9P46,6MQT,6MQG,421P,821P,1PLL,1PLJ,1JAI,1CLU,8UN3,8UN5,7L0G,8TLR,1PLK,1JAH,4L9W,4L9S GTPase NRas RASN_HUMAN P01111 Q14971 Q15104 Q15282 211113 C#Cc1c(F)ccc2cc(O)cc(-c3ncc4c([C@H]5[C@@H]6CNC[C@@H]65)nn(C5CC5)c4c3F)c12 InChI=1S/C26H20F2N4O/c1-2-15-20(27)6-3-12-7-14(33)8-16(21(12)15)25-23(28)26-19(11-30-25)24(31-32(26)13-4-5-13)22-17-9-29-10-18(17)22/h1,3,6-8,11,13,17-18,22,29,33H,4-5,9-10H2 KRVHXOFDTPBNHQ-UHFFFAOYSA-N 372329 US20260022118, Example 4 GTPase NRas [G12D] 20.5 US Patent 10.7270/Q2SN0FTF US20260022118 NAGY, E; MANDAL, PK; JONES, P; SOTH, MJ; CROSS, JB; REYNA, NJ; COX, J; MCAFOOS, TJ; TRAN, TN 1/22/2026 6/3/2026 University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372329 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2110&target=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372329&enzyme=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 132254849 402359270 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDLPTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKKLNSSDDGTQGCMGLPCVVM 8TBI,3CON,9P46,6MQT,6MQG,421P,821P,1PLL,1PLJ,1JAI,1CLU,8UN3,8UN5,7L0G,8TLR,1PLK,1JAH,4L9W,4L9S GTPase NRas RASN_HUMAN P01111 Q14971 Q15104 Q15282 211114 C#Cc1c(F)ccc2cc(O)cc(-c3ncc4c([C@H]5[C@@H]6CNC[C@@H]65)cn(C5CC5)c4c3F)c12 InChI=1S/C27H21F2N3O/c1-2-16-22(28)6-3-13-7-15(33)8-17(23(13)16)26-25(29)27-20(11-31-26)21(12-32(27)14-4-5-14)24-18-9-30-10-19(18)24/h1,3,6-8,11-12,14,18-19,24,30,33H,4-5,9-10H2 BHPOPTGAZXXKHU-UHFFFAOYSA-N 372330 US20260022118, Example 5 GTPase NRas [G12D] 10.1 US Patent 10.7270/Q2SN0FTF US20260022118 NAGY, E; MANDAL, PK; JONES, P; SOTH, MJ; CROSS, JB; REYNA, NJ; COX, J; MCAFOOS, TJ; TRAN, TN 1/22/2026 6/3/2026 University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372330 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2110&target=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372330&enzyme=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 132254496 402359271 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDLPTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKKLNSSDDGTQGCMGLPCVVM 8TBI,3CON,9P46,6MQT,6MQG,421P,821P,1PLL,1PLJ,1JAI,1CLU,8UN3,8UN5,7L0G,8TLR,1PLK,1JAH,4L9W,4L9S GTPase NRas RASN_HUMAN P01111 Q14971 Q15104 Q15282 211115 C#Cc1c(F)ccc2cc(O)cc(-c3cc4c(cn3)c(N3CC5CCC(C3)N5)nn4CC)c12 InChI=1S/C26H24FN5O/c1-3-19-22(27)8-5-15-9-18(33)10-20(25(15)19)23-11-24-21(12-28-23)26(30-32(24)4-2)31-13-16-6-7-17(14-31)29-16/h1,5,8-12,16-17,29,33H,4,6-7,13-14H2,2H3 PAWXMXGLFWLLDI-UHFFFAOYSA-N 372331 4-(3-(3,8-diazabicyclo[3.2.1]octan-3-yl)-1- ethyl-1H-pyrazolo[4,3-c]pyridin-6-yl)-5- ethynyl-6-fluoronaphthalen-2-ol::US20260022118, Example 6 GTPase NRas [G12D] 8200 US Patent 10.7270/Q2SN0FTF US20260022118 NAGY, E; MANDAL, PK; JONES, P; SOTH, MJ; CROSS, JB; REYNA, NJ; COX, J; MCAFOOS, TJ; TRAN, TN 1/22/2026 6/3/2026 University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372331 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2110&target=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372331&enzyme=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 132254817 402359272 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDLPTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKKLNSSDDGTQGCMGLPCVVM 8TBI,3CON,9P46,6MQT,6MQG,421P,821P,1PLL,1PLJ,1JAI,1CLU,8UN3,8UN5,7L0G,8TLR,1PLK,1JAH,4L9W,4L9S GTPase NRas RASN_HUMAN P01111 Q14971 Q15104 Q15282 211116 C#Cc1c(F)ccc2cc(O)cc(-c3cc4c(cn3)c(N3CC5CCC(C3)N5)nn4CCC)c12 InChI=1S/C27H26FN5O/c1-3-9-33-25-12-24(21-11-19(34)10-16-5-8-23(28)20(4-2)26(16)21)29-13-22(25)27(31-33)32-14-17-6-7-18(15-32)30-17/h2,5,8,10-13,17-18,30,34H,3,6-7,9,14-15H2,1H3 JRZDBJCCSXEJFW-UHFFFAOYSA-N 372332 4-(3-(3,8-diazabicyclo[3.2.1]octan-3-yl)-1- propyl-1H-pyrazolo[4,3-c]pyridin-6-yl)-5- ethynyl-6-fluoronaphthalen-2-ol::US20260022118, Example 7 GTPase NRas [G12D] 4750 US Patent 10.7270/Q2SN0FTF US20260022118 NAGY, E; MANDAL, PK; JONES, P; SOTH, MJ; CROSS, JB; REYNA, NJ; COX, J; MCAFOOS, TJ; TRAN, TN 1/22/2026 6/3/2026 University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372332 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2110&target=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372332&enzyme=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 132254444 402359273 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDLPTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKKLNSSDDGTQGCMGLPCVVM 8TBI,3CON,9P46,6MQT,6MQG,421P,821P,1PLL,1PLJ,1JAI,1CLU,8UN3,8UN5,7L0G,8TLR,1PLK,1JAH,4L9W,4L9S GTPase NRas RASN_HUMAN P01111 Q14971 Q15104 Q15282 211117 C#Cc1c(F)ccc2cc(O)cc(-c3ncc4c(N5CC6CCC(C5)N6)nn(CC)c4c3F)c12 InChI=1S/C26H23F2N5O/c1-3-18-21(27)8-5-14-9-17(34)10-19(22(14)18)24-23(28)25-20(11-29-24)26(31-33(25)4-2)32-12-15-6-7-16(13-32)30-15/h1,5,8-11,15-16,30,34H,4,6-7,12-13H2,2H3 JNJAKQDJPHAWEB-UHFFFAOYSA-N 372333 4-(3-(3,8-diazabicyclo[3.2.1]octan-3-yl)-1- ethyl-7-fluoro-1H-pyrazolo[4,3-c]pyridin-6-yl)- 5-ethynyl-6-fluoronaphthalen-2-ol::US20260022118, Example 8 GTPase NRas [G12D] 1920 US Patent 10.7270/Q2SN0FTF US20260022118 NAGY, E; MANDAL, PK; JONES, P; SOTH, MJ; CROSS, JB; REYNA, NJ; COX, J; MCAFOOS, TJ; TRAN, TN 1/22/2026 6/3/2026 University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372333 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2110&target=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372333&enzyme=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 132254456 402359274 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDLPTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKKLNSSDDGTQGCMGLPCVVM 8TBI,3CON,9P46,6MQT,6MQG,421P,821P,1PLL,1PLJ,1JAI,1CLU,8UN3,8UN5,7L0G,8TLR,1PLK,1JAH,4L9W,4L9S GTPase NRas RASN_HUMAN P01111 Q14971 Q15104 Q15282 211118 C#Cc1c(F)ccc2cc(O)cc(-c3ncc4c(C5=CC6CCC(C5)N6)nn(CC)c4c3F)c12 InChI=1S/C27H22F2N4O/c1-3-19-22(28)8-5-14-11-18(34)12-20(23(14)19)26-24(29)27-21(13-30-26)25(32-33(27)4-2)15-9-16-6-7-17(10-15)31-16/h1,5,8-9,11-13,16-17,31,34H,4,6-7,10H2,2H3 HBOFCFRSTLPSNK-UHFFFAOYSA-N 372334 4-(3-(8-azabicyclo[3.2.1]oct-2-en-3-yl)-1-ethyl- 7-fluoro-1H-pyrazolo[4,3-c]pyridin-6-yl)-5- ethynyl-6-fluoronaphthalen-2-ol::US20260022118, Example 9 GTPase NRas [G12D] 16200 US Patent 10.7270/Q2SN0FTF US20260022118 NAGY, E; MANDAL, PK; JONES, P; SOTH, MJ; CROSS, JB; REYNA, NJ; COX, J; MCAFOOS, TJ; TRAN, TN 1/22/2026 6/3/2026 University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372334 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2110&target=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372334&enzyme=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 132254813 402359275 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDLPTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKKLNSSDDGTQGCMGLPCVVM 8TBI,3CON,9P46,6MQT,6MQG,421P,821P,1PLL,1PLJ,1JAI,1CLU,8UN3,8UN5,7L0G,8TLR,1PLK,1JAH,4L9W,4L9S GTPase NRas RASN_HUMAN P01111 Q14971 Q15104 Q15282 211119 C#Cc1c(F)ccc2cc(O)cc(-c3ncc4c(N5CCNCC5)nn(CC)c4c3F)c12 InChI=1S/C24H21F2N5O/c1-3-16-19(25)6-5-14-11-15(32)12-17(20(14)16)22-21(26)23-18(13-28-22)24(29-31(23)4-2)30-9-7-27-8-10-30/h1,5-6,11-13,27,32H,4,7-10H2,2H3 CGGQMNXECGEGEL-UHFFFAOYSA-N 372335 4-(1-ethyl-7-fluoro-3-(piperazin-1-yl)-1H- pyrazolo[4,3-c]pyridin-6-yl)-5-ethynyl-6- fluoronaphthalen-2-ol::US20260022118, Example 10 GTPase NRas [G12D] 38700 US Patent 10.7270/Q2SN0FTF US20260022118 NAGY, E; MANDAL, PK; JONES, P; SOTH, MJ; CROSS, JB; REYNA, NJ; COX, J; MCAFOOS, TJ; TRAN, TN 1/22/2026 6/3/2026 University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372335 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2110&target=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372335&enzyme=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 132254597 402359276 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDLPTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKKLNSSDDGTQGCMGLPCVVM 8TBI,3CON,9P46,6MQT,6MQG,421P,821P,1PLL,1PLJ,1JAI,1CLU,8UN3,8UN5,7L0G,8TLR,1PLK,1JAH,4L9W,4L9S GTPase NRas RASN_HUMAN P01111 Q14971 Q15104 Q15282 211120 C#Cc1c(F)ccc2cc(O)cc(-c3ncc4c(N[C@H]5[C@@H]6CNC[C@@H]65)nn(CC)c4c3F)c12 InChI=1S/C25H21F2N5O/c1-3-14-19(26)6-5-12-7-13(33)8-15(20(12)14)23-21(27)24-18(11-29-23)25(31-32(24)4-2)30-22-16-9-28-10-17(16)22/h1,5-8,11,16-17,22,28,33H,4,9-10H2,2H3,(H,30,31) QEROTOZBRJFZBJ-UHFFFAOYSA-N 372336 4-(3-(((1R,5S,6s)-3-azabicyclo[3.1.0]hexan-6- yl)amino)-1-ethyl-7-fluoro-1H-pyrazolo[4,3- c]pyridin-6-yl)-5-ethynyl-6-fluoronaphthalen-2- ol::US20260022118, Example 11 GTPase NRas [G12D] 31000 US Patent 10.7270/Q2SN0FTF US20260022118 NAGY, E; MANDAL, PK; JONES, P; SOTH, MJ; CROSS, JB; REYNA, NJ; COX, J; MCAFOOS, TJ; TRAN, TN 1/22/2026 6/3/2026 University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372336 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2110&target=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372336&enzyme=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 132254549 402359277 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDLPTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKKLNSSDDGTQGCMGLPCVVM 8TBI,3CON,9P46,6MQT,6MQG,421P,821P,1PLL,1PLJ,1JAI,1CLU,8UN3,8UN5,7L0G,8TLR,1PLK,1JAH,4L9W,4L9S GTPase NRas RASN_HUMAN P01111 Q14971 Q15104 Q15282 211121 C#Cc1c(F)ccc2cc(O)cc(-c3ncc4c(NCC5(N(C)C)CCC5)nn(CC)c4c3F)c12 InChI=1S/C27H27F2N5O/c1-5-18-21(28)9-8-16-12-17(35)13-19(22(16)18)24-23(29)25-20(14-30-24)26(32-34(25)6-2)31-15-27(33(3)4)10-7-11-27/h1,8-9,12-14,35H,6-7,10-11,15H2,2-4H3,(H,31,32) IWANVKUVRLDRRT-UHFFFAOYSA-N 372337 4-(3-(((1- (dimethylamino)cyclobutyl)methyl)amino)-1- ethyl-7-fluoro-1H-pyrazolo[4,3-c]pyridin-6-yl)- 5-ethynyl-6-fluoronaphthalen-2-ol::US20260022118, Example 12 GTPase NRas [G12D] 8350 US Patent 10.7270/Q2SN0FTF US20260022118 NAGY, E; MANDAL, PK; JONES, P; SOTH, MJ; CROSS, JB; REYNA, NJ; COX, J; MCAFOOS, TJ; TRAN, TN 1/22/2026 6/3/2026 University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372337 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2110&target=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372337&enzyme=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 132254654 402359278 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDLPTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKKLNSSDDGTQGCMGLPCVVM 8TBI,3CON,9P46,6MQT,6MQG,421P,821P,1PLL,1PLJ,1JAI,1CLU,8UN3,8UN5,7L0G,8TLR,1PLK,1JAH,4L9W,4L9S GTPase NRas RASN_HUMAN P01111 Q14971 Q15104 Q15282 211122 C#Cc1c(F)ccc2cc(O)cc(-c3ncc4c(N5CC6CCC(C5)N6)nn(C)c4c3F)c12 InChI=1S/C25H21F2N5O/c1-3-17-20(26)7-4-13-8-16(33)9-18(21(13)17)23-22(27)24-19(10-28-23)25(30-31(24)2)32-11-14-5-6-15(12-32)29-14/h1,4,7-10,14-15,29,33H,5-6,11-12H2,2H3 FSGJYLKEEVFTSP-UHFFFAOYSA-N 372338 4-(3-(3,8-diazabicyclo[3.2.1]octan-3-yl)-7- fluoro-1-methyl-1H-pyrazolo[4,3-c]pyridin-6- yl)-5-ethynyl-6-fluoronaphthalen-2-ol::US20260022118, Example 13 GTPase NRas [G12D] 891 US Patent 10.7270/Q2SN0FTF US20260022118 NAGY, E; MANDAL, PK; JONES, P; SOTH, MJ; CROSS, JB; REYNA, NJ; COX, J; MCAFOOS, TJ; TRAN, TN 1/22/2026 6/3/2026 University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372338 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2110&target=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372338&enzyme=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 132255034 402359279 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDLPTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKKLNSSDDGTQGCMGLPCVVM 8TBI,3CON,9P46,6MQT,6MQG,421P,821P,1PLL,1PLJ,1JAI,1CLU,8UN3,8UN5,7L0G,8TLR,1PLK,1JAH,4L9W,4L9S GTPase NRas RASN_HUMAN P01111 Q14971 Q15104 Q15282 211123 C#Cc1c(F)ccc2cc(O)cc(-c3ncc4c(N5CC6CCC(C5)N6)nn(CCC)c4c3F)c12 InChI=1S/C27H25F2N5O/c1-3-9-34-26-21(27(32-34)33-13-16-6-7-17(14-33)31-16)12-30-25(24(26)29)20-11-18(35)10-15-5-8-22(28)19(4-2)23(15)20/h2,5,8,10-12,16-17,31,35H,3,6-7,9,13-14H2,1H3 LMPPAJRIGYHBBX-UHFFFAOYSA-N 373132 4-(3-(3,8-diazabicyclo[3.2.1]octan-3-yl)-7- fluoro-1-propyl-1H-pyrazolo[4,3-c]pyridin-6- yl)-5-ethynyl-6-fluoronaphthalen-2-ol::US20260022118, Example 14 GTPase NRas [G12D] 4410 US Patent 10.7270/Q2SN0FTF US20260022118 NAGY, E; MANDAL, PK; JONES, P; SOTH, MJ; CROSS, JB; REYNA, NJ; COX, J; MCAFOOS, TJ; TRAN, TN 1/22/2026 6/3/2026 University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373132 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2110&target=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373132&enzyme=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 117732745 404342237 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDLPTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKKLNSSDDGTQGCMGLPCVVM 8TBI,3CON,9P46,6MQT,6MQG,421P,821P,1PLL,1PLJ,1JAI,1CLU,8UN3,8UN5,7L0G,8TLR,1PLK,1JAH,4L9W,4L9S GTPase NRas RASN_HUMAN P01111 Q14971 Q15104 Q15282 211124 C#Cc1c(F)ccc2cc(O)cc(-c3ncc4c(N5CC6CCC(C5)N6)nn(CC5CCOC5)c4c3F)c12 InChI=1S/C29H27F2N5O2/c1-2-21-24(30)6-3-17-9-20(37)10-22(25(17)21)27-26(31)28-23(11-32-27)29(34-36(28)12-16-7-8-38-15-16)35-13-18-4-5-19(14-35)33-18/h1,3,6,9-11,16,18-19,33,37H,4-5,7-8,12-15H2 KKKQAHJJFUVBCD-UHFFFAOYSA-N 373133 4-(3-(3,8-diazabicyclo[3.2.1]octan-3-yl)-7- fluoro-1-((tetrahydrofuran-3-yl)methyl)-1H- pyrazolo[4,3-c]pyridin-6-yl)-5-ethynyl-6- fluoronaphthalen-2-ol::US20260022118, Example 15 GTPase NRas [G12D] 5970 US Patent 10.7270/Q2SN0FTF US20260022118 NAGY, E; MANDAL, PK; JONES, P; SOTH, MJ; CROSS, JB; REYNA, NJ; COX, J; MCAFOOS, TJ; TRAN, TN 1/22/2026 6/3/2026 University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373133 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2110&target=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373133&enzyme=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 71715611 404342238 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDLPTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKKLNSSDDGTQGCMGLPCVVM 8TBI,3CON,9P46,6MQT,6MQG,421P,821P,1PLL,1PLJ,1JAI,1CLU,8UN3,8UN5,7L0G,8TLR,1PLK,1JAH,4L9W,4L9S GTPase NRas RASN_HUMAN P01111 Q14971 Q15104 Q15282 211125 C#Cc1c(F)ccc2cc(O)cc(-c3ncc4c(N5CC6CCC(C5)N6)nn(C5CCC5)c4c3F)c12 InChI=1S/C28H25F2N5O/c1-2-20-23(29)9-6-15-10-19(36)11-21(24(15)20)26-25(30)27-22(12-31-26)28(33-35(27)18-4-3-5-18)34-13-16-7-8-17(14-34)32-16/h1,6,9-12,16-18,32,36H,3-5,7-8,13-14H2 FZFFDOZAOGFBGR-UHFFFAOYSA-N 373134 4-(3-(3,8-diazabicyclo[3.2.1]octan-3-yl)-1- cyclobutyl-7-fluoro-1H-pyrazolo[4,3-c]pyridin- 6-yl)-5-ethynyl-6-fluoronaphthalen-2-ol::US20260022118, Example 16 GTPase NRas [G12D] 5650 US Patent 10.7270/Q2SN0FTF US20260022118 NAGY, E; MANDAL, PK; JONES, P; SOTH, MJ; CROSS, JB; REYNA, NJ; COX, J; MCAFOOS, TJ; TRAN, TN 1/22/2026 6/3/2026 University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373134 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2110&target=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373134&enzyme=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 117732716 404342239 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDLPTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKKLNSSDDGTQGCMGLPCVVM 8TBI,3CON,9P46,6MQT,6MQG,421P,821P,1PLL,1PLJ,1JAI,1CLU,8UN3,8UN5,7L0G,8TLR,1PLK,1JAH,4L9W,4L9S GTPase NRas RASN_HUMAN P01111 Q14971 Q15104 Q15282 211126 C#Cc1c(F)ccc2cc(O)cc(-c3ncc4c(N5CC6CCC(C5)N6)n[nH]c4c3F)c12 InChI=1S/C24H19F2N5O/c1-2-16-19(25)6-3-12-7-15(32)8-17(20(12)16)22-21(26)23-18(9-27-22)24(30-29-23)31-10-13-4-5-14(11-31)28-13/h1,3,6-9,13-14,28,32H,4-5,10-11H2,(H,29,30) LTVLZXAGDQWODY-UHFFFAOYSA-N 373135 4-(3-(3,8-diazabicyclo[3.2.1]octan-3-yl)-7- fluoro-1H-pyrazolo[4,3-c]pyridin-6-yl)-5- ethynyl-6-fluoronaphthalen-2-ol::US20260022118, Example 17 GTPase NRas [G12D] 30800 US Patent 10.7270/Q2SN0FTF US20260022118 NAGY, E; MANDAL, PK; JONES, P; SOTH, MJ; CROSS, JB; REYNA, NJ; COX, J; MCAFOOS, TJ; TRAN, TN 1/22/2026 6/3/2026 University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373135 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2110&target=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373135&enzyme=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 117732737 404342240 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDLPTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKKLNSSDDGTQGCMGLPCVVM 8TBI,3CON,9P46,6MQT,6MQG,421P,821P,1PLL,1PLJ,1JAI,1CLU,8UN3,8UN5,7L0G,8TLR,1PLK,1JAH,4L9W,4L9S GTPase NRas RASN_HUMAN P01111 Q14971 Q15104 Q15282 211127 C#Cc1c(F)ccc2cc(O)cc(-c3cc4[nH]nc(N5CC6CCC(C5)N6)c4cn3)c12 InChI=1S/C24H20FN5O/c1-2-17-20(25)6-3-13-7-16(31)8-18(23(13)17)21-9-22-19(10-26-21)24(29-28-22)30-11-14-4-5-15(12-30)27-14/h1,3,6-10,14-15,27,31H,4-5,11-12H2,(H,28,29) VUFRZHOWEMBCNB-UHFFFAOYSA-N 373136 4-(3-(3,8-diazabicyclo[3.2.1]octan-3-yl)-1H- pyrazolo[4,3-c]pyridin-6-yl)-5-ethynyl-6- fluoronaphthalen-2-ol::US20260022118, Example 18 GTPase NRas [G12D] 40500 US Patent 10.7270/Q2SN0FTF US20260022118 NAGY, E; MANDAL, PK; JONES, P; SOTH, MJ; CROSS, JB; REYNA, NJ; COX, J; MCAFOOS, TJ; TRAN, TN 1/22/2026 6/3/2026 University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373136 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2110&target=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373136&enzyme=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 71715781 404342241 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDLPTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKKLNSSDDGTQGCMGLPCVVM 8TBI,3CON,9P46,6MQT,6MQG,421P,821P,1PLL,1PLJ,1JAI,1CLU,8UN3,8UN5,7L0G,8TLR,1PLK,1JAH,4L9W,4L9S GTPase NRas RASN_HUMAN P01111 Q14971 Q15104 Q15282 211128 C#Cc1c(F)ccc2cc(O)cc(-c3cc4c(cn3)c(N3C5CCC3CNC5)nn4C)c12 InChI=1S/C25H22FN5O/c1-3-18-21(26)7-4-14-8-17(32)9-19(24(14)18)22-10-23-20(13-28-22)25(29-30(23)2)31-15-5-6-16(31)12-27-11-15/h1,4,7-10,13,15-16,27,32H,5-6,11-12H2,2H3 CXPPYDSUONPMLM-UHFFFAOYSA-N 373137 4-(3-(3,8-diazabicyclo[3.2.1]octan-8-yl)-1- methyl-1H-pyrazolo[4,3-c]pyridin-6-yl)-5- ethynyl-6-fluoronaphthalen-2-ol::US20260022118, Example 19 GTPase NRas [G12D] 6100 US Patent 10.7270/Q2SN0FTF US20260022118 NAGY, E; MANDAL, PK; JONES, P; SOTH, MJ; CROSS, JB; REYNA, NJ; COX, J; MCAFOOS, TJ; TRAN, TN 1/22/2026 6/3/2026 University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373137 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2110&target=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373137&enzyme=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 71715782 404342242 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDLPTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKKLNSSDDGTQGCMGLPCVVM 8TBI,3CON,9P46,6MQT,6MQG,421P,821P,1PLL,1PLJ,1JAI,1CLU,8UN3,8UN5,7L0G,8TLR,1PLK,1JAH,4L9W,4L9S GTPase NRas RASN_HUMAN P01111 Q14971 Q15104 Q15282 211129 C#Cc1c(F)ccc2cc(O)cc(-c3ncc4c([C@H]5[C@@H]6CNC[C@@H]65)nn(CC)c4c3F)c12 InChI=1S/C25H20F2N4O/c1-3-14-19(26)6-5-12-7-13(32)8-15(20(12)14)24-22(27)25-18(11-29-24)23(30-31(25)4-2)21-16-9-28-10-17(16)21/h1,5-8,11,16-17,21,28,32H,4,9-10H2,2H3 BFMMYCZWTBMNED-UHFFFAOYSA-N 373138 4-(3-((1R,5S,6r)-3-azabicyclo[3.1.0]hexan-6- yl)-1-ethyl-7-fluoro-1H-pyrazolo[4,3-c]pyridin- 6-yl)-5-ethynyl-6-fluoronaphthalen-2-ol::US20260022118, Example 20 GTPase NRas [G12D] 159 US Patent 10.7270/Q2SN0FTF US20260022118 NAGY, E; MANDAL, PK; JONES, P; SOTH, MJ; CROSS, JB; REYNA, NJ; COX, J; MCAFOOS, TJ; TRAN, TN 1/22/2026 6/3/2026 University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373138 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2110&target=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373138&enzyme=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 71715783 404342243 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDLPTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKKLNSSDDGTQGCMGLPCVVM 8TBI,3CON,9P46,6MQT,6MQG,421P,821P,1PLL,1PLJ,1JAI,1CLU,8UN3,8UN5,7L0G,8TLR,1PLK,1JAH,4L9W,4L9S GTPase NRas RASN_HUMAN P01111 Q14971 Q15104 Q15282 211130 C#Cc1c(F)ccc2cc(O)cc(-c3ncc4c([C@H]5[C@@H]6CNC[C@@H]65)c(C)n(C)c4c3F)c12 InChI=1S/C26H21F2N3O/c1-4-15-20(27)6-5-13-7-14(32)8-16(22(13)15)25-24(28)26-19(11-30-25)21(12(2)31(26)3)23-17-9-29-10-18(17)23/h1,5-8,11,17-18,23,29,32H,9-10H2,2-3H3 YXWMJCPEFDIDAI-UHFFFAOYSA-N 373139 4-(3-((1R,5S,6s)-3-azabicyclo[3.1.0]hexan-6- yl)-7-fluoro-1,2-dimethyl-1H-pyrrolo[3,2- c]pyridin-6-yl)-5-ethynyl-6-fluoronaphthalen-2- ol::US20260022118, Example 21 GTPase NRas [G12D] 1840 US Patent 10.7270/Q2SN0FTF US20260022118 NAGY, E; MANDAL, PK; JONES, P; SOTH, MJ; CROSS, JB; REYNA, NJ; COX, J; MCAFOOS, TJ; TRAN, TN 1/22/2026 6/3/2026 University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373139 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2110&target=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373139&enzyme=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 89739415 404342244 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDLPTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKKLNSSDDGTQGCMGLPCVVM 8TBI,3CON,9P46,6MQT,6MQG,421P,821P,1PLL,1PLJ,1JAI,1CLU,8UN3,8UN5,7L0G,8TLR,1PLK,1JAH,4L9W,4L9S GTPase NRas RASN_HUMAN P01111 Q14971 Q15104 Q15282 211131 C#Cc1c(F)ccc2cc(O)cc(-c3cc4c(cn3)c([C@H]3[C@@H]5CNC[C@@H]53)cn4C)c12 InChI=1S/C25H20FN3O/c1-3-15-21(26)5-4-13-6-14(30)7-16(24(13)15)22-8-23-17(11-28-22)20(12-29(23)2)25-18-9-27-10-19(18)25/h1,4-8,11-12,18-19,25,27,30H,9-10H2,2H3 IHATTXAMDOATJH-UHFFFAOYSA-N 373140 4-(3-((1R,5S,6s)-3-azabicyclo[3.1.0]hexan-6- yl)-1-methyl-1H-pyrrolo[3,2-c]pyridin-6-yl)-5- ethynyl-6-fluoronaphthalen-2-ol::US20260022118, Example 22 GTPase NRas [G12D] 1640 US Patent 10.7270/Q2SN0FTF US20260022118 NAGY, E; MANDAL, PK; JONES, P; SOTH, MJ; CROSS, JB; REYNA, NJ; COX, J; MCAFOOS, TJ; TRAN, TN 1/22/2026 6/3/2026 University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373140 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2110&target=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373140&enzyme=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 71715839 404342245 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDLPTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKKLNSSDDGTQGCMGLPCVVM 8TBI,3CON,9P46,6MQT,6MQG,421P,821P,1PLL,1PLJ,1JAI,1CLU,8UN3,8UN5,7L0G,8TLR,1PLK,1JAH,4L9W,4L9S GTPase NRas RASN_HUMAN P01111 Q14971 Q15104 Q15282 211132 C#Cc1c(F)ccc2cc(O)cc(-c3ncc4c([C@H]5[C@@H]6CNC[C@@H]65)c(CO)n(C)c4c3F)c12 InChI=1S/C26H21F2N3O2/c1-3-14-19(27)5-4-12-6-13(33)7-15(21(12)14)25-24(28)26-18(10-30-25)23(20(11-32)31(26)2)22-16-8-29-9-17(16)22/h1,4-7,10,16-17,22,29,32-33H,8-9,11H2,2H3 GMFZGUJKKUFQQH-UHFFFAOYSA-N 373141 4-(3-((1R,5S,6s)-3-azabicyclo[3.1.0]hexan-6- yl)-7-fluoro-2-(hydroxymethyl)-1-methyl-1H- pyrrolo[3,2-c]pyridin-6-yl)-5-ethynyl-6- fluoronaphthalen-2-ol::US20260022118, Example 23 GTPase NRas [G12D] 13700 US Patent 10.7270/Q2SN0FTF US20260022118 NAGY, E; MANDAL, PK; JONES, P; SOTH, MJ; CROSS, JB; REYNA, NJ; COX, J; MCAFOOS, TJ; TRAN, TN 1/22/2026 6/3/2026 University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373141 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2110&target=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373141&enzyme=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 71715840 404342246 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDLPTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKKLNSSDDGTQGCMGLPCVVM 8TBI,3CON,9P46,6MQT,6MQG,421P,821P,1PLL,1PLJ,1JAI,1CLU,8UN3,8UN5,7L0G,8TLR,1PLK,1JAH,4L9W,4L9S GTPase NRas RASN_HUMAN P01111 Q14971 Q15104 Q15282 211133 C#Cc1c(F)ccc2cc(O)cc(-c3ncc4c([C@H]5[C@@H]6CNC[C@@H]65)nn(C(C)C)c4c3F)c12 InChI=1S/C26H22F2N4O/c1-4-15-20(27)6-5-13-7-14(33)8-16(21(13)15)25-23(28)26-19(11-30-25)24(31-32(26)12(2)3)22-17-9-29-10-18(17)22/h1,5-8,11-12,17-18,22,29,33H,9-10H2,2-3H3 VAGLLUBBAKRLKY-UHFFFAOYSA-N 373142 4-(3-((1R,5S,6r)-3-azabicyclo[3.1.0]hexan-6- yl)-7-fluoro-1-isopropyl-1H-pyrazolo[4,3- c]pyridin-6-yl)-5-ethynyl-6-fluoronaphthalen-2- ol::US20260022118, Example 24 GTPase NRas [G12D] 824 US Patent 10.7270/Q2SN0FTF US20260022118 NAGY, E; MANDAL, PK; JONES, P; SOTH, MJ; CROSS, JB; REYNA, NJ; COX, J; MCAFOOS, TJ; TRAN, TN 1/22/2026 6/3/2026 University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373142 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2110&target=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373142&enzyme=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 71715841 404342247 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDLPTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKKLNSSDDGTQGCMGLPCVVM 8TBI,3CON,9P46,6MQT,6MQG,421P,821P,1PLL,1PLJ,1JAI,1CLU,8UN3,8UN5,7L0G,8TLR,1PLK,1JAH,4L9W,4L9S GTPase NRas RASN_HUMAN P01111 Q14971 Q15104 Q15282 211134 C#Cc1c(F)ccc2cc(O)cc(-c3ncc4c(N5CC6CCC5CN6)nn(C)c4c3F)c12 InChI=1S/C25H21F2N5O/c1-3-17-20(26)7-4-13-8-16(33)9-18(21(13)17)23-22(27)24-19(11-29-23)25(30-31(24)2)32-12-14-5-6-15(32)10-28-14/h1,4,7-9,11,14-15,28,33H,5-6,10,12H2,2H3 UYSCCLKJAPAKEQ-UHFFFAOYSA-N 373147 4-(3-(2,5-diazabicyclo[2.2.2]octan-2-yl)-7- fluoro-1-methyl-1H-pyrazolo[4,3-c]pyridin-6- yl)-5-ethynyl-6-fluoronaphthalen-2-ol::US20260022118, Example 26 GTPase NRas [G12D] 73.8 US Patent 10.7270/Q2SN0FTF US20260022118 NAGY, E; MANDAL, PK; JONES, P; SOTH, MJ; CROSS, JB; REYNA, NJ; COX, J; MCAFOOS, TJ; TRAN, TN 1/22/2026 6/3/2026 University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373147 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2110&target=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373147&enzyme=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 89748213 404342251 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDLPTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKKLNSSDDGTQGCMGLPCVVM 8TBI,3CON,9P46,6MQT,6MQG,421P,821P,1PLL,1PLJ,1JAI,1CLU,8UN3,8UN5,7L0G,8TLR,1PLK,1JAH,4L9W,4L9S GTPase NRas RASN_HUMAN P01111 Q14971 Q15104 Q15282 211135 C#Cc1c(F)ccc2cc(O)cc(-c3ccc4c([C@H]5[C@@H]6CNC[C@@H]65)nn(C)c4c3F)c12 InChI=1S/C25H19F2N3O/c1-3-14-20(26)7-4-12-8-13(31)9-17(21(12)14)15-5-6-16-24(22-18-10-28-11-19(18)22)29-30(2)25(16)23(15)27/h1,4-9,18-19,22,28,31H,10-11H2,2H3 XMWICOZDCNGJJI-UHFFFAOYSA-N 373151 4-(3-((1R,5S,6r)-3-azabicyclo[3.1.0]hexan-6- yl)-7-fluoro-1-methyl-1H-indazol-6-yl)-5- ethynyl-6-fluoronaphthalen-2-ol::US20260022118, Example 27 GTPase NRas [G12D] 3180 US Patent 10.7270/Q2SN0FTF US20260022118 NAGY, E; MANDAL, PK; JONES, P; SOTH, MJ; CROSS, JB; REYNA, NJ; COX, J; MCAFOOS, TJ; TRAN, TN 1/22/2026 6/3/2026 University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373151 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2110&target=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373151&enzyme=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 89748237 404342253 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDLPTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKKLNSSDDGTQGCMGLPCVVM 8TBI,3CON,9P46,6MQT,6MQG,421P,821P,1PLL,1PLJ,1JAI,1CLU,8UN3,8UN5,7L0G,8TLR,1PLK,1JAH,4L9W,4L9S GTPase NRas RASN_HUMAN P01111 Q14971 Q15104 Q15282 211136 C#Cc1c(F)ccc2cc(O)cc(-c3ncc4c(N5CC6CC5CN6)nn(C)c4c3F)c12 InChI=1S/C24H19F2N5O/c1-3-16-19(25)5-4-12-6-15(32)8-17(20(12)16)22-21(26)23-18(10-28-22)24(29-30(23)2)31-11-13-7-14(31)9-27-13/h1,4-6,8,10,13-14,27,32H,7,9,11H2,2H3 SZPOKASHVQWZCR-UHFFFAOYSA-N 373152 4-(3-(2,5-diazabicyclo[2.2.1]heptan-2-yl)-7- fluoro-1-methyl-1H-pyrazolo[4,3-c]pyridin-6- yl)-5-ethynyl-6-fluoronaphthalen-2-ol::US20260022118, Example 28 GTPase NRas [G12D] 1100 US Patent 10.7270/Q2SN0FTF US20260022118 NAGY, E; MANDAL, PK; JONES, P; SOTH, MJ; CROSS, JB; REYNA, NJ; COX, J; MCAFOOS, TJ; TRAN, TN 1/22/2026 6/3/2026 University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373152 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2110&target=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373152&enzyme=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 89739456 404342254 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDLPTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKKLNSSDDGTQGCMGLPCVVM 8TBI,3CON,9P46,6MQT,6MQG,421P,821P,1PLL,1PLJ,1JAI,1CLU,8UN3,8UN5,7L0G,8TLR,1PLK,1JAH,4L9W,4L9S GTPase NRas RASN_HUMAN P01111 Q14971 Q15104 Q15282 211137 C#Cc1c(F)ccc2cc(O)cc(-c3c(F)cc4c([C@H]5[C@@H]6CNC[C@@H]65)cn(C)c4c3F)c12 InChI=1S/C26H19F3N2O/c1-3-14-20(27)5-4-12-6-13(32)7-16(22(12)14)24-21(28)8-15-19(11-31(2)26(15)25(24)29)23-17-9-30-10-18(17)23/h1,4-8,11,17-18,23,30,32H,9-10H2,2H3 DRTMQTBFONNNAJ-UHFFFAOYSA-N 373154 4-(3-((1R,5S,6s)-3-azabicyclo[3.1.0]hexan-6- yl)-5,7-difluoro-1-methyl-1H-indol-6-yl)-5- ethynyl-6-fluoronaphthalen-2-ol::US20260022118, Example 29 GTPase NRas [G12D] 965 US Patent 10.7270/Q2SN0FTF US20260022118 NAGY, E; MANDAL, PK; JONES, P; SOTH, MJ; CROSS, JB; REYNA, NJ; COX, J; MCAFOOS, TJ; TRAN, TN 1/22/2026 6/3/2026 University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373154 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2110&target=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373154&enzyme=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 89739635 404342256 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDLPTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKKLNSSDDGTQGCMGLPCVVM 8TBI,3CON,9P46,6MQT,6MQG,421P,821P,1PLL,1PLJ,1JAI,1CLU,8UN3,8UN5,7L0G,8TLR,1PLK,1JAH,4L9W,4L9S GTPase NRas RASN_HUMAN P01111 Q14971 Q15104 Q15282 211138 C#Cc1c(F)ccc2cc(O)cc(-c3ncc4c(N5C[C@@H]6CC[C@H]5CN6)nn(C)c4c3F)c12 InChI=1S/C25H21F2N5O/c1-3-17-20(26)7-4-13-8-16(33)9-18(21(13)17)23-22(27)24-19(11-29-23)25(30-31(24)2)32-12-14-5-6-15(32)10-28-14/h1,4,7-9,11,14-15,28,33H,5-6,10,12H2,2H3 UYSCCLKJAPAKEQ-UHFFFAOYSA-N 373155 4-(3-((1S,4S)-2,5-diazabicyclo[2.2.2]octan-2- yl)-7-fluoro-1-methyl-1H-pyrazolo[4,3- c]pyridin-6-yl)-5-ethynyl-6-fluoronaphthalen-2- ol::US20260022118, Example 30 GTPase NRas [G12D] 51.9 US Patent 10.7270/Q2SN0FTF US20260022118 NAGY, E; MANDAL, PK; JONES, P; SOTH, MJ; CROSS, JB; REYNA, NJ; COX, J; MCAFOOS, TJ; TRAN, TN 1/22/2026 6/3/2026 University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373155 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2110&target=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373155&enzyme=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 89748225 404342257 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDLPTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKKLNSSDDGTQGCMGLPCVVM 8TBI,3CON,9P46,6MQT,6MQG,421P,821P,1PLL,1PLJ,1JAI,1CLU,8UN3,8UN5,7L0G,8TLR,1PLK,1JAH,4L9W,4L9S GTPase NRas RASN_HUMAN P01111 Q14971 Q15104 Q15282 211139 C#Cc1c(F)ccc2cc(O)cc(-c3ncc4c(N5CC6CCCC(C5)N6)nn(C)c4c3F)c12 InChI=1S/C26H23F2N5O/c1-3-18-21(27)8-7-14-9-17(34)10-19(22(14)18)24-23(28)25-20(11-29-24)26(31-32(25)2)33-12-15-5-4-6-16(13-33)30-15/h1,7-11,15-16,30,34H,4-6,12-13H2,2H3 GXYMODDCRYGCIL-UHFFFAOYSA-N 373156 US20260022118, Example 31 GTPase NRas [G12D] 3430 US Patent 10.7270/Q2SN0FTF US20260022118 NAGY, E; MANDAL, PK; JONES, P; SOTH, MJ; CROSS, JB; REYNA, NJ; COX, J; MCAFOOS, TJ; TRAN, TN 1/22/2026 6/3/2026 University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373156 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2110&target=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373156&enzyme=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 89739245 404342258 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDLPTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKKLNSSDDGTQGCMGLPCVVM 8TBI,3CON,9P46,6MQT,6MQG,421P,821P,1PLL,1PLJ,1JAI,1CLU,8UN3,8UN5,7L0G,8TLR,1PLK,1JAH,4L9W,4L9S GTPase NRas RASN_HUMAN P01111 Q14971 Q15104 Q15282 211140 C#Cc1c(F)ccc2cc(O)cc(-c3ncc4c(N5CC(N(C)C)C5)nn(C)c4c3F)c12 InChI=1S/C24H21F2N5O/c1-5-16-19(25)7-6-13-8-15(32)9-17(20(13)16)22-21(26)23-18(10-27-22)24(28-30(23)4)31-11-14(12-31)29(2)3/h1,6-10,14,32H,11-12H2,2-4H3 LBHNHQWGYULFNP-UHFFFAOYSA-N 373157 4-[3-[3-(dimethylamino)azetidin-1-yl]-7-fluoro-1-methyl-pyrazolo[4,3-c]pyridin-6-yl]-5-ethynyl-6-fluoro-naphthalen-2-ol::US20260022118, Example 33 GTPase NRas [G12D] 8750 US Patent 10.7270/Q2SN0FTF US20260022118 NAGY, E; MANDAL, PK; JONES, P; SOTH, MJ; CROSS, JB; REYNA, NJ; COX, J; MCAFOOS, TJ; TRAN, TN 1/22/2026 6/3/2026 University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373157 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2110&target=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373157&enzyme=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 89748238 404342259 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDLPTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKKLNSSDDGTQGCMGLPCVVM 8TBI,3CON,9P46,6MQT,6MQG,421P,821P,1PLL,1PLJ,1JAI,1CLU,8UN3,8UN5,7L0G,8TLR,1PLK,1JAH,4L9W,4L9S GTPase NRas RASN_HUMAN P01111 Q14971 Q15104 Q15282 211141 C#Cc1c(F)ccc2cc(O)cc(-c3ncc4c(N5CC6CC(C5)N6)nn(C)c4c3F)c12 InChI=1S/C24H19F2N5O/c1-3-16-19(25)5-4-12-6-15(32)8-17(20(12)16)22-21(26)23-18(9-27-22)24(29-30(23)2)31-10-13-7-14(11-31)28-13/h1,4-6,8-9,13-14,28,32H,7,10-11H2,2H3 GNGHCVHPRUNPIH-UHFFFAOYSA-N 373158 US20260022118, Example 34 GTPase NRas [G12D] 613 US Patent 10.7270/Q2SN0FTF US20260022118 NAGY, E; MANDAL, PK; JONES, P; SOTH, MJ; CROSS, JB; REYNA, NJ; COX, J; MCAFOOS, TJ; TRAN, TN 1/22/2026 6/3/2026 University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373158 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2110&target=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373158&enzyme=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 89739372 404342260 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDLPTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKKLNSSDDGTQGCMGLPCVVM 8TBI,3CON,9P46,6MQT,6MQG,421P,821P,1PLL,1PLJ,1JAI,1CLU,8UN3,8UN5,7L0G,8TLR,1PLK,1JAH,4L9W,4L9S GTPase NRas RASN_HUMAN P01111 Q14971 Q15104 Q15282 211142 C#Cc1c(F)ccc2cc(O)cc(-c3ncc4c(N5CC6CCCC5CN6)nn(C)c4c3F)c12 InChI=1S/C26H23F2N5O/c1-3-18-21(27)8-7-14-9-17(34)10-19(22(14)18)24-23(28)25-20(12-30-24)26(31-32(25)2)33-13-15-5-4-6-16(33)11-29-15/h1,7-10,12,15-16,29,34H,4-6,11,13H2,2H3 SJMUUGDPCBZPJD-UHFFFAOYSA-N 373159 US20260022118, Example 36 GTPase NRas [G12D] 4030 US Patent 10.7270/Q2SN0FTF US20260022118 NAGY, E; MANDAL, PK; JONES, P; SOTH, MJ; CROSS, JB; REYNA, NJ; COX, J; MCAFOOS, TJ; TRAN, TN 1/22/2026 6/3/2026 University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373159 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2110&target=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373159&enzyme=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 89748149 404342261 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDLPTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKKLNSSDDGTQGCMGLPCVVM 8TBI,3CON,9P46,6MQT,6MQG,421P,821P,1PLL,1PLJ,1JAI,1CLU,8UN3,8UN5,7L0G,8TLR,1PLK,1JAH,4L9W,4L9S GTPase NRas RASN_HUMAN P01111 Q14971 Q15104 Q15282 211143 C#Cc1c(F)ccc2cc(O)cc(-c3ncc4c(c(C)cn4C4=CC5CCC4CN5)c3F)c12 InChI=1S/C27H21F2N3O/c1-3-19-21(28)7-5-15-8-18(33)10-20(25(15)19)27-26(29)24-14(2)13-32(23(24)12-31-27)22-9-17-6-4-16(22)11-30-17/h1,5,7-10,12-13,16-17,30,33H,4,6,11H2,2H3 XIRQWHIJANMBEI-UHFFFAOYSA-N 373160 US20260022118, Example 38 GTPase NRas [G12D] 3990 US Patent 10.7270/Q2SN0FTF US20260022118 NAGY, E; MANDAL, PK; JONES, P; SOTH, MJ; CROSS, JB; REYNA, NJ; COX, J; MCAFOOS, TJ; TRAN, TN 1/22/2026 6/3/2026 University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373160 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2110&target=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373160&enzyme=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 89748150 404342262 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDLPTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKKLNSSDDGTQGCMGLPCVVM 8TBI,3CON,9P46,6MQT,6MQG,421P,821P,1PLL,1PLJ,1JAI,1CLU,8UN3,8UN5,7L0G,8TLR,1PLK,1JAH,4L9W,4L9S GTPase NRas RASN_HUMAN P01111 Q14971 Q15104 Q15282 211144 C#Cc1c(F)ccc2cc(O)cc(-c3ncc4c(c(C)cn4C4CC5CCC4CN5)c3F)c12 InChI=1S/C27H23F2N3O/c1-3-19-21(28)7-5-15-8-18(33)10-20(25(15)19)27-26(29)24-14(2)13-32(23(24)12-31-27)22-9-17-6-4-16(22)11-30-17/h1,5,7-8,10,12-13,16-17,22,30,33H,4,6,9,11H2,2H3 XSNIOOHYXZUYJG-UHFFFAOYSA-N 373161 US20260022118, Example 39 GTPase NRas [G12D] 435 US Patent 10.7270/Q2SN0FTF US20260022118 NAGY, E; MANDAL, PK; JONES, P; SOTH, MJ; CROSS, JB; REYNA, NJ; COX, J; MCAFOOS, TJ; TRAN, TN 1/22/2026 6/3/2026 University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373161 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2110&target=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373161&enzyme=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 89740812 404342263 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDLPTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKKLNSSDDGTQGCMGLPCVVM 8TBI,3CON,9P46,6MQT,6MQG,421P,821P,1PLL,1PLJ,1JAI,1CLU,8UN3,8UN5,7L0G,8TLR,1PLK,1JAH,4L9W,4L9S GTPase NRas RASN_HUMAN P01111 Q14971 Q15104 Q15282 211145 C#Cc1c(F)ccc2cc(O)cc(-c3ncc4c(c(C)cn4C4[C@H]5CNC[C@@H]45)c3F)c12 InChI=1S/C25H19F2N3O/c1-3-15-19(26)5-4-13-6-14(31)7-16(22(13)15)24-23(27)21-12(2)11-30(20(21)10-29-24)25-17-8-28-9-18(17)25/h1,4-7,10-11,17-18,25,28,31H,8-9H2,2H3 DZWNLJOEEGCGLY-UHFFFAOYSA-N 373164 US20260022118, Example 40 GTPase NRas [G12D] 1130 US Patent 10.7270/Q2SN0FTF US20260022118 NAGY, E; MANDAL, PK; JONES, P; SOTH, MJ; CROSS, JB; REYNA, NJ; COX, J; MCAFOOS, TJ; TRAN, TN 1/22/2026 6/3/2026 University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373164 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2110&target=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373164&enzyme=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 89748144 404342266 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDLPTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKKLNSSDDGTQGCMGLPCVVM 8TBI,3CON,9P46,6MQT,6MQG,421P,821P,1PLL,1PLJ,1JAI,1CLU,8UN3,8UN5,7L0G,8TLR,1PLK,1JAH,4L9W,4L9S GTPase NRas RASN_HUMAN P01111 Q14971 Q15104 Q15282 211146 C#Cc1c(F)ccc2cc(O)cc(-c3ncc4c(C5=CC6CCC5CN6)nn(C)c4c3F)c12 InChI=1S/C26H20F2N4O/c1-3-17-21(27)7-5-13-8-16(33)10-19(22(13)17)25-23(28)26-20(12-30-25)24(31-32(26)2)18-9-15-6-4-14(18)11-29-15/h1,5,7-10,12,14-15,29,33H,4,6,11H2,2H3 KROFIYHMFMMRCG-UHFFFAOYSA-N 373165 US20260022118, Example 42 GTPase NRas [G12D] 2980 US Patent 10.7270/Q2SN0FTF US20260022118 NAGY, E; MANDAL, PK; JONES, P; SOTH, MJ; CROSS, JB; REYNA, NJ; COX, J; MCAFOOS, TJ; TRAN, TN 1/22/2026 6/3/2026 University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373165 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2110&target=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373165&enzyme=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 77914734 404342267 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDLPTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKKLNSSDDGTQGCMGLPCVVM 8TBI,3CON,9P46,6MQT,6MQG,421P,821P,1PLL,1PLJ,1JAI,1CLU,8UN3,8UN5,7L0G,8TLR,1PLK,1JAH,4L9W,4L9S GTPase NRas RASN_HUMAN P01111 Q14971 Q15104 Q15282 211147 C#Cc1c(F)ccc2cc(O)cc(-c3ncc4c(C5CC6CCC5CN6)nn(C)c4c3F)c12 InChI=1S/C26H22F2N4O/c1-3-17-21(27)7-5-13-8-16(33)10-19(22(13)17)25-23(28)26-20(12-30-25)24(31-32(26)2)18-9-15-6-4-14(18)11-29-15/h1,5,7-8,10,12,14-15,18,29,33H,4,6,9,11H2,2H3 ABSRXWONLUOTJX-UHFFFAOYSA-N 373166 US20260022118, Example 44 GTPase NRas [G12D] 201 US Patent 10.7270/Q2SN0FTF US20260022118 NAGY, E; MANDAL, PK; JONES, P; SOTH, MJ; CROSS, JB; REYNA, NJ; COX, J; MCAFOOS, TJ; TRAN, TN 1/22/2026 6/3/2026 University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373166 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2110&target=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373166&enzyme=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 77910111 404342268 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDLPTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKKLNSSDDGTQGCMGLPCVVM 8TBI,3CON,9P46,6MQT,6MQG,421P,821P,1PLL,1PLJ,1JAI,1CLU,8UN3,8UN5,7L0G,8TLR,1PLK,1JAH,4L9W,4L9S GTPase NRas RASN_HUMAN P01111 Q14971 Q15104 Q15282 211148 C#Cc1c(F)ccc2cc(O)cc(-c3ncc4c(c3F)n(C)c(=O)n4C3[C@H]4CNC[C@@H]34)c12 InChI=1S/C24H18F2N4O2/c1-3-13-17(25)5-4-11-6-12(31)7-14(19(11)13)21-20(26)23-18(10-28-21)30(24(32)29(23)2)22-15-8-27-9-16(15)22/h1,4-7,10,15-16,22,27,31H,8-9H2,2H3 QXLGJDXMAYKKMK-UHFFFAOYSA-N 373167 US20260022118, Example 45 GTPase NRas [G12D] 9940 US Patent 10.7270/Q2SN0FTF US20260022118 NAGY, E; MANDAL, PK; JONES, P; SOTH, MJ; CROSS, JB; REYNA, NJ; COX, J; MCAFOOS, TJ; TRAN, TN 1/22/2026 6/3/2026 University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373167 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2110&target=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373167&enzyme=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 89748143 404342269 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDLPTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKKLNSSDDGTQGCMGLPCVVM 8TBI,3CON,9P46,6MQT,6MQG,421P,821P,1PLL,1PLJ,1JAI,1CLU,8UN3,8UN5,7L0G,8TLR,1PLK,1JAH,4L9W,4L9S GTPase NRas RASN_HUMAN P01111 Q14971 Q15104 Q15282 211149 C#Cc1c(F)ccc2cc(O)cc(-c3ncc4c([C@H]5[C@@H]6CNC[C@@H]65)nn(C5C[C@@H]5C)c4c3F)c12 InChI=1S/C27H22F2N4O/c1-3-15-20(28)5-4-13-7-14(34)8-16(22(13)15)26-24(29)27-19(11-31-26)25(23-17-9-30-10-18(17)23)32-33(27)21-6-12(21)2/h1,4-5,7-8,11-12,17-18,21,23,30,34H,6,9-10H2,2H3 PICRQQSUAAUHNR-UHFFFAOYSA-N 373168 US20260022118, Example 46 GTPase NRas [G12D] 60.7 US Patent 10.7270/Q2SN0FTF US20260022118 NAGY, E; MANDAL, PK; JONES, P; SOTH, MJ; CROSS, JB; REYNA, NJ; COX, J; MCAFOOS, TJ; TRAN, TN 1/22/2026 6/3/2026 University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373168 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2110&target=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373168&enzyme=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 89739795 404342270 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDLPTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKKLNSSDDGTQGCMGLPCVVM 8TBI,3CON,9P46,6MQT,6MQG,421P,821P,1PLL,1PLJ,1JAI,1CLU,8UN3,8UN5,7L0G,8TLR,1PLK,1JAH,4L9W,4L9S GTPase NRas RASN_HUMAN P01111 Q14971 Q15104 Q15282 211150 C#Cc1c(F)ccc2cc(O)cc(-c3ncc4c([C@H]5[C@@H]6CNC[C@@H]65)nn(C5CC5F)c4c3F)c12 InChI=1S/C26H19F3N4O/c1-2-13-18(27)4-3-11-5-12(34)6-14(21(11)13)25-23(29)26-17(10-31-25)24(22-15-8-30-9-16(15)22)32-33(26)20-7-19(20)28/h1,3-6,10,15-16,19-20,22,30,34H,7-9H2 NBSLKGQFTHPEFW-UHFFFAOYSA-N 373169 US20260022118, Example 49 GTPase NRas [G12D] 81.5 US Patent 10.7270/Q2SN0FTF US20260022118 NAGY, E; MANDAL, PK; JONES, P; SOTH, MJ; CROSS, JB; REYNA, NJ; COX, J; MCAFOOS, TJ; TRAN, TN 1/22/2026 6/3/2026 University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373169 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2110&target=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373169&enzyme=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 89739887 404342271 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDLPTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKKLNSSDDGTQGCMGLPCVVM 8TBI,3CON,9P46,6MQT,6MQG,421P,821P,1PLL,1PLJ,1JAI,1CLU,8UN3,8UN5,7L0G,8TLR,1PLK,1JAH,4L9W,4L9S GTPase NRas RASN_HUMAN P01111 Q14971 Q15104 Q15282 211151 C#Cc1c(F)ccc2cc(O)cc(-c3ncc4c(N5C[C@@H]6C[C@H](O)[C@H](C5)N6)nn(C)c4c3F)c12 InChI=1S/C25H21F2N5O2/c1-3-15-18(26)5-4-12-6-14(33)8-16(21(12)15)23-22(27)24-17(9-28-23)25(30-31(24)2)32-10-13-7-20(34)19(11-32)29-13/h1,4-6,8-9,13,19-20,29,33-34H,7,10-11H2,2H3 QUAWFYCFAHVVBY-UHFFFAOYSA-N 373170 US20260022118, Example 57 GTPase NRas [G12D] 737 US Patent 10.7270/Q2SN0FTF US20260022118 NAGY, E; MANDAL, PK; JONES, P; SOTH, MJ; CROSS, JB; REYNA, NJ; COX, J; MCAFOOS, TJ; TRAN, TN 1/22/2026 6/3/2026 University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373170 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2110&target=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373170&enzyme=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 89739624 404342272 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDLPTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKKLNSSDDGTQGCMGLPCVVM 8TBI,3CON,9P46,6MQT,6MQG,421P,821P,1PLL,1PLJ,1JAI,1CLU,8UN3,8UN5,7L0G,8TLR,1PLK,1JAH,4L9W,4L9S GTPase NRas RASN_HUMAN P01111 Q14971 Q15104 Q15282 211152 C#Cc1c(F)ccc2cc(O)cc(-c3ncc4c([C@H]5[C@@H]6CNC[C@@H]65)c(C#N)n(C)c4c3F)c12 InChI=1S/C26H18F2N4O/c1-3-14-19(27)5-4-12-6-13(33)7-15(21(12)14)25-24(28)26-18(11-31-25)23(20(8-29)32(26)2)22-16-9-30-10-17(16)22/h1,4-7,11,16-17,22,30,33H,9-10H2,2H3 BPWXVLWCKWMRAI-UHFFFAOYSA-N 373171 US20260022118, Example 58 GTPase NRas [G12D] 300 US Patent 10.7270/Q2SN0FTF US20260022118 NAGY, E; MANDAL, PK; JONES, P; SOTH, MJ; CROSS, JB; REYNA, NJ; COX, J; MCAFOOS, TJ; TRAN, TN 1/22/2026 6/3/2026 University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373171 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2110&target=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373171&enzyme=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 71715161 404342273 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDLPTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKKLNSSDDGTQGCMGLPCVVM 8TBI,3CON,9P46,6MQT,6MQG,421P,821P,1PLL,1PLJ,1JAI,1CLU,8UN3,8UN5,7L0G,8TLR,1PLK,1JAH,4L9W,4L9S GTPase NRas RASN_HUMAN P01111 Q14971 Q15104 Q15282 211153 C#CCn1nc([C@H]2[C@@H]3CNC[C@@H]32)c2cnc(-c3cc(O)cc4ccc(F)c(C#C)c34)c(F)c21 InChI=1S/C26H18F2N4O/c1-3-7-32-26-19(24(31-32)22-17-10-29-11-18(17)22)12-30-25(23(26)28)16-9-14(33)8-13-5-6-20(27)15(4-2)21(13)16/h1-2,5-6,8-9,12,17-18,22,29,33H,7,10-11H2 DGUYPQFZZQVZKF-UHFFFAOYSA-N 373172 US20260022118, Example 59 GTPase NRas [G12D] 1110 US Patent 10.7270/Q2SN0FTF US20260022118 NAGY, E; MANDAL, PK; JONES, P; SOTH, MJ; CROSS, JB; REYNA, NJ; COX, J; MCAFOOS, TJ; TRAN, TN 1/22/2026 6/3/2026 University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373172 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2110&target=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373172&enzyme=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 77912472 404342274 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDLPTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKKLNSSDDGTQGCMGLPCVVM 8TBI,3CON,9P46,6MQT,6MQG,421P,821P,1PLL,1PLJ,1JAI,1CLU,8UN3,8UN5,7L0G,8TLR,1PLK,1JAH,4L9W,4L9S GTPase NRas RASN_HUMAN P01111 Q14971 Q15104 Q15282 211154 C#Cc1c(F)ccc2cc(O)cc(-c3ncc4c(N5C[C@H]6CC[C@@H]5CN6)nn(C)c4c3F)c12 InChI=1S/C25H21F2N5O/c1-3-17-20(26)7-4-13-8-16(33)9-18(21(13)17)23-22(27)24-19(11-29-23)25(30-31(24)2)32-12-14-5-6-15(32)10-28-14/h1,4,7-9,11,14-15,28,33H,5-6,10,12H2,2H3 UYSCCLKJAPAKEQ-UHFFFAOYSA-N 373173 US20260022118, Example 60 GTPase NRas [G12D] 2550 US Patent 10.7270/Q2SN0FTF US20260022118 NAGY, E; MANDAL, PK; JONES, P; SOTH, MJ; CROSS, JB; REYNA, NJ; COX, J; MCAFOOS, TJ; TRAN, TN 1/22/2026 6/3/2026 University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373173 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2110&target=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373173&enzyme=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 71715162 404342275 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDLPTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKKLNSSDDGTQGCMGLPCVVM 8TBI,3CON,9P46,6MQT,6MQG,421P,821P,1PLL,1PLJ,1JAI,1CLU,8UN3,8UN5,7L0G,8TLR,1PLK,1JAH,4L9W,4L9S GTPase NRas RASN_HUMAN P01111 Q14971 Q15104 Q15282 211155 C#Cc1c(F)ccc2cc(O)cc(-c3nc(OC)c4c([C@H]5[C@@H]6CNC[C@@H]65)nn(C5CC5)c4c3F)c12 InChI=1S/C27H22F2N4O2/c1-3-15-19(28)7-4-12-8-14(34)9-16(20(12)15)24-23(29)26-22(27(31-24)35-2)25(32-33(26)13-5-6-13)21-17-10-30-11-18(17)21/h1,4,7-9,13,17-18,21,30,34H,5-6,10-11H2,2H3 NSIKETGAHXFYAG-UHFFFAOYSA-N 373174 US20260022118, Example 61 GTPase NRas [G12D] 15.8 US Patent 10.7270/Q2SN0FTF US20260022118 NAGY, E; MANDAL, PK; JONES, P; SOTH, MJ; CROSS, JB; REYNA, NJ; COX, J; MCAFOOS, TJ; TRAN, TN 1/22/2026 6/3/2026 University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373174 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2110&target=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373174&enzyme=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 71715219 404342276 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDLPTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKKLNSSDDGTQGCMGLPCVVM 8TBI,3CON,9P46,6MQT,6MQG,421P,821P,1PLL,1PLJ,1JAI,1CLU,8UN3,8UN5,7L0G,8TLR,1PLK,1JAH,4L9W,4L9S GTPase NRas RASN_HUMAN P01111 Q14971 Q15104 Q15282 211156 C#Cc1c(F)ccc2cc(O)cc(-c3nc(OC(C)C)c4c([C@H]5[C@@H]6CNC[C@@H]65)nn(C5CC5)c4c3F)c12 InChI=1S/C29H26F2N4O2/c1-4-17-21(30)8-5-14-9-16(36)10-18(22(14)17)26-25(31)28-24(29(33-26)37-13(2)3)27(34-35(28)15-6-7-15)23-19-11-32-12-20(19)23/h1,5,8-10,13,15,19-20,23,32,36H,6-7,11-12H2,2-3H3 OCGYDHZQBVTLKV-UHFFFAOYSA-N 373175 US20260022118, Example 62 GTPase NRas [G12D] 18.8 US Patent 10.7270/Q2SN0FTF US20260022118 NAGY, E; MANDAL, PK; JONES, P; SOTH, MJ; CROSS, JB; REYNA, NJ; COX, J; MCAFOOS, TJ; TRAN, TN 1/22/2026 6/3/2026 University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373175 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2110&target=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373175&enzyme=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 71715220 404342277 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDLPTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKKLNSSDDGTQGCMGLPCVVM 8TBI,3CON,9P46,6MQT,6MQG,421P,821P,1PLL,1PLJ,1JAI,1CLU,8UN3,8UN5,7L0G,8TLR,1PLK,1JAH,4L9W,4L9S GTPase NRas RASN_HUMAN P01111 Q14971 Q15104 Q15282 211157 C#Cc1c(F)ccc2cc(O)cc(-c3nc(OCC)c4c([C@H]5[C@@H]6CNC[C@@H]65)nn(C5CC5)c4c3F)c12 InChI=1S/C28H24F2N4O2/c1-3-16-20(29)8-5-13-9-15(35)10-17(21(13)16)25-24(30)27-23(28(32-25)36-4-2)26(33-34(27)14-6-7-14)22-18-11-31-12-19(18)22/h1,5,8-10,14,18-19,22,31,35H,4,6-7,11-12H2,2H3 QJRYWGPPZUYLGP-UHFFFAOYSA-N 373176 US20260022118, Example 63 GTPase NRas [G12D] 8.29 US Patent 10.7270/Q2SN0FTF US20260022118 NAGY, E; MANDAL, PK; JONES, P; SOTH, MJ; CROSS, JB; REYNA, NJ; COX, J; MCAFOOS, TJ; TRAN, TN 1/22/2026 6/3/2026 University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373176 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2110&target=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373176&enzyme=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 71715221 404342278 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDLPTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKKLNSSDDGTQGCMGLPCVVM 8TBI,3CON,9P46,6MQT,6MQG,421P,821P,1PLL,1PLJ,1JAI,1CLU,8UN3,8UN5,7L0G,8TLR,1PLK,1JAH,4L9W,4L9S GTPase NRas RASN_HUMAN P01111 Q14971 Q15104 Q15282 211158 C#Cc1c(F)ccc2cc(O)cc(-c3nc(OC4CCC4)c4c([C@H]5[C@@H]6CNC[C@@H]65)nn(C5CC5)c4c3F)c12 InChI=1S/C30H26F2N4O2/c1-2-18-22(31)9-6-14-10-16(37)11-19(23(14)18)27-26(32)29-25(30(34-27)38-17-4-3-5-17)28(35-36(29)15-7-8-15)24-20-12-33-13-21(20)24/h1,6,9-11,15,17,20-21,24,33,37H,3-5,7-8,12-13H2 XYIOYXHJVREIFZ-UHFFFAOYSA-N 373177 US20260022118, Example 64 GTPase NRas [G12D] 24.3 US Patent 10.7270/Q2SN0FTF US20260022118 NAGY, E; MANDAL, PK; JONES, P; SOTH, MJ; CROSS, JB; REYNA, NJ; COX, J; MCAFOOS, TJ; TRAN, TN 1/22/2026 6/3/2026 University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373177 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2110&target=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373177&enzyme=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 71661445 404342279 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDLPTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKKLNSSDDGTQGCMGLPCVVM 8TBI,3CON,9P46,6MQT,6MQG,421P,821P,1PLL,1PLJ,1JAI,1CLU,8UN3,8UN5,7L0G,8TLR,1PLK,1JAH,4L9W,4L9S GTPase NRas RASN_HUMAN P01111 Q14971 Q15104 Q15282 211159 C#Cc1c(F)ccc2cc(O)cc(-c3nc(OC4CCCC4)c4c([C@H]5[C@@H]6CNC[C@@H]65)nn(C5CC5)c4c3F)c12 InChI=1S/C31H28F2N4O2/c1-2-19-23(32)10-7-15-11-17(38)12-20(24(15)19)28-27(33)30-26(31(35-28)39-18-5-3-4-6-18)29(36-37(30)16-8-9-16)25-21-13-34-14-22(21)25/h1,7,10-12,16,18,21-22,25,34,38H,3-6,8-9,13-14H2 GIABYPKJZWFWLC-UHFFFAOYSA-N 373178 US20260022118, Example 65 GTPase NRas [G12D] 125 US Patent 10.7270/Q2SN0FTF US20260022118 NAGY, E; MANDAL, PK; JONES, P; SOTH, MJ; CROSS, JB; REYNA, NJ; COX, J; MCAFOOS, TJ; TRAN, TN 1/22/2026 6/3/2026 University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373178 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2110&target=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373178&enzyme=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 89748158 404342280 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDLPTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKKLNSSDDGTQGCMGLPCVVM 8TBI,3CON,9P46,6MQT,6MQG,421P,821P,1PLL,1PLJ,1JAI,1CLU,8UN3,8UN5,7L0G,8TLR,1PLK,1JAH,4L9W,4L9S GTPase NRas RASN_HUMAN P01111 Q14971 Q15104 Q15282 211160 C#Cc1c(F)ccc2cc(O)cc(-c3nc(OC(F)F)c4c([C@H]5[C@@H]6CNC[C@@H]65)nn(C5CC5)c4c3F)c12 InChI=1S/C27H20F4N4O2/c1-2-14-18(28)6-3-11-7-13(36)8-15(19(11)14)23-22(29)25-21(26(33-23)37-27(30)31)24(34-35(25)12-4-5-12)20-16-9-32-10-17(16)20/h1,3,6-8,12,16-17,20,27,32,36H,4-5,9-10H2 MOSHMBAYVDRMTA-UHFFFAOYSA-N 373179 US20260022118, Example 66 GTPase NRas [G12D] 114 US Patent 10.7270/Q2SN0FTF US20260022118 NAGY, E; MANDAL, PK; JONES, P; SOTH, MJ; CROSS, JB; REYNA, NJ; COX, J; MCAFOOS, TJ; TRAN, TN 1/22/2026 6/3/2026 University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373179 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2110&target=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373179&enzyme=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 71715222 404342281 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDLPTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKKLNSSDDGTQGCMGLPCVVM 8TBI,3CON,9P46,6MQT,6MQG,421P,821P,1PLL,1PLJ,1JAI,1CLU,8UN3,8UN5,7L0G,8TLR,1PLK,1JAH,4L9W,4L9S GTPase NRas RASN_HUMAN P01111 Q14971 Q15104 Q15282 211161 C#Cc1c(F)ccc2cc(O)cc(-c3nc(OCC(F)(F)F)c4c([C@H]5[C@@H]6CNC[C@@H]65)nn(C5CC5)c4c3F)c12 InChI=1S/C28H21F5N4O2/c1-2-15-19(29)6-3-12-7-14(38)8-16(20(12)15)24-23(30)26-22(27(35-24)39-11-28(31,32)33)25(36-37(26)13-4-5-13)21-17-9-34-10-18(17)21/h1,3,6-8,13,17-18,21,34,38H,4-5,9-11H2 RVQKKTSDLKFDJK-UHFFFAOYSA-N 373180 US20260022118, Example 67 GTPase NRas [G12D] 114 US Patent 10.7270/Q2SN0FTF US20260022118 NAGY, E; MANDAL, PK; JONES, P; SOTH, MJ; CROSS, JB; REYNA, NJ; COX, J; MCAFOOS, TJ; TRAN, TN 1/22/2026 6/3/2026 University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373180 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2110&target=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373180&enzyme=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 71715223 404342282 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDLPTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKKLNSSDDGTQGCMGLPCVVM 8TBI,3CON,9P46,6MQT,6MQG,421P,821P,1PLL,1PLJ,1JAI,1CLU,8UN3,8UN5,7L0G,8TLR,1PLK,1JAH,4L9W,4L9S GTPase NRas RASN_HUMAN P01111 Q14971 Q15104 Q15282 211162 C#Cc1c(F)ccc2cc(O)cc(-c3nc(OC4CC(F)(F)C4)c4c([C@H]5[C@@H]6CNC[C@@H]65)nn(C5CC5)c4c3F)c12 InChI=1S/C30H24F4N4O2/c1-2-17-21(31)6-3-13-7-15(39)8-18(22(13)17)26-25(32)28-24(29(36-26)40-16-9-30(33,34)10-16)27(37-38(28)14-4-5-14)23-19-11-35-12-20(19)23/h1,3,6-8,14,16,19-20,23,35,39H,4-5,9-12H2 YVAOUKITKQXIEF-UHFFFAOYSA-N 373181 US20260022118, Example 68 GTPase NRas [G12D] 566 US Patent 10.7270/Q2SN0FTF US20260022118 NAGY, E; MANDAL, PK; JONES, P; SOTH, MJ; CROSS, JB; REYNA, NJ; COX, J; MCAFOOS, TJ; TRAN, TN 1/22/2026 6/3/2026 University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373181 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2110&target=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373181&enzyme=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 71715275 404342283 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDLPTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKKLNSSDDGTQGCMGLPCVVM 8TBI,3CON,9P46,6MQT,6MQG,421P,821P,1PLL,1PLJ,1JAI,1CLU,8UN3,8UN5,7L0G,8TLR,1PLK,1JAH,4L9W,4L9S GTPase NRas RASN_HUMAN P01111 Q14971 Q15104 Q15282 211163 C#Cc1c(F)ccc2cc(O)cc(-c3nc(OC4CNC4)c4c([C@H]5[C@@H]6CNC[C@@H]65)nn(C5CC5)c4c3F)c12 InChI=1S/C29H25F2N5O2/c1-2-17-21(30)6-3-13-7-15(37)8-18(22(13)17)26-25(31)28-24(29(34-26)38-16-9-32-10-16)27(35-36(28)14-4-5-14)23-19-11-33-12-20(19)23/h1,3,6-8,14,16,19-20,23,32-33,37H,4-5,9-12H2 AVKRKPNYHNIKKG-UHFFFAOYSA-N 373182 US20260022118, Example 69 GTPase NRas [G12D] 1790 US Patent 10.7270/Q2SN0FTF US20260022118 NAGY, E; MANDAL, PK; JONES, P; SOTH, MJ; CROSS, JB; REYNA, NJ; COX, J; MCAFOOS, TJ; TRAN, TN 1/22/2026 6/3/2026 University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373182 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2110&target=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373182&enzyme=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 71715276 404342284 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDLPTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKKLNSSDDGTQGCMGLPCVVM 8TBI,3CON,9P46,6MQT,6MQG,421P,821P,1PLL,1PLJ,1JAI,1CLU,8UN3,8UN5,7L0G,8TLR,1PLK,1JAH,4L9W,4L9S GTPase NRas RASN_HUMAN P01111 Q14971 Q15104 Q15282 211164 C#Cc1c(F)ccc2cc(O)cc(-c3nc(OC4CC4)c4c([C@H]5[C@@H]6CNC[C@@H]65)nn(C5CC5)c4c3F)c12 InChI=1S/C29H24F2N4O2/c1-2-17-21(30)8-3-13-9-15(36)10-18(22(13)17)26-25(31)28-24(29(33-26)37-16-6-7-16)27(34-35(28)14-4-5-14)23-19-11-32-12-20(19)23/h1,3,8-10,14,16,19-20,23,32,36H,4-7,11-12H2 ZMUHQGIJDANANM-UHFFFAOYSA-N 373183 US20260022118, Example 70 GTPase NRas [G12D] 33.3 US Patent 10.7270/Q2SN0FTF US20260022118 NAGY, E; MANDAL, PK; JONES, P; SOTH, MJ; CROSS, JB; REYNA, NJ; COX, J; MCAFOOS, TJ; TRAN, TN 1/22/2026 6/3/2026 University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373183 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2110&target=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373183&enzyme=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 71715277 404342285 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDLPTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKKLNSSDDGTQGCMGLPCVVM 8TBI,3CON,9P46,6MQT,6MQG,421P,821P,1PLL,1PLJ,1JAI,1CLU,8UN3,8UN5,7L0G,8TLR,1PLK,1JAH,4L9W,4L9S GTPase NRas RASN_HUMAN P01111 Q14971 Q15104 Q15282 211165 C#Cc1c(F)ccc2cc(O)cc(-c3nc(CC)c4c([C@H]5[C@@H]6CNC[C@@H]65)nn(C5CC5)c4c3F)c12 InChI=1S/C28H24F2N4O/c1-3-16-20(29)8-5-13-9-15(35)10-17(22(13)16)26-25(30)28-24(21(4-2)32-26)27(33-34(28)14-6-7-14)23-18-11-31-12-19(18)23/h1,5,8-10,14,18-19,23,31,35H,4,6-7,11-12H2,2H3 RSCWLXNAYRHGDN-UHFFFAOYSA-N 373184 US20260022118, Example 72 GTPase NRas [G12D] 0.594 US Patent 10.7270/Q2SN0FTF US20260022118 NAGY, E; MANDAL, PK; JONES, P; SOTH, MJ; CROSS, JB; REYNA, NJ; COX, J; MCAFOOS, TJ; TRAN, TN 1/22/2026 6/3/2026 University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373184 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2110&target=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373184&enzyme=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 71715278 404342286 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDLPTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKKLNSSDDGTQGCMGLPCVVM 8TBI,3CON,9P46,6MQT,6MQG,421P,821P,1PLL,1PLJ,1JAI,1CLU,8UN3,8UN5,7L0G,8TLR,1PLK,1JAH,4L9W,4L9S GTPase NRas RASN_HUMAN P01111 Q14971 Q15104 Q15282 211166 C#Cc1c(F)ccc2cc(O)cc(-c3nc(CC(C)C)c4c([C@H]5[C@@H]6CNC[C@@H]65)nn(C5CC5)c4c3F)c12 InChI=1S/C30H28F2N4O/c1-4-18-22(31)8-5-15-10-17(37)11-19(24(15)18)28-27(32)30-26(23(34-28)9-14(2)3)29(35-36(30)16-6-7-16)25-20-12-33-13-21(20)25/h1,5,8,10-11,14,16,20-21,25,33,37H,6-7,9,12-13H2,2-3H3 TTZSLVIOSOYPDV-UHFFFAOYSA-N 373185 US20260022118, Example 73 GTPase NRas [G12D] 212 US Patent 10.7270/Q2SN0FTF US20260022118 NAGY, E; MANDAL, PK; JONES, P; SOTH, MJ; CROSS, JB; REYNA, NJ; COX, J; MCAFOOS, TJ; TRAN, TN 1/22/2026 6/3/2026 University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373185 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2110&target=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373185&enzyme=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 71715279 404342287 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDLPTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKKLNSSDDGTQGCMGLPCVVM 8TBI,3CON,9P46,6MQT,6MQG,421P,821P,1PLL,1PLJ,1JAI,1CLU,8UN3,8UN5,7L0G,8TLR,1PLK,1JAH,4L9W,4L9S GTPase NRas RASN_HUMAN P01111 Q14971 Q15104 Q15282 211167 C#Cc1c(F)ccc2cc(O)cc(-c3nc(C(C)C)c4c([C@H]5[C@@H]6CNC[C@@H]65)nn(C5CC5)c4c3F)c12 InChI=1S/C29H26F2N4O/c1-4-17-21(30)8-5-14-9-16(36)10-18(22(14)17)27-25(31)29-24(26(33-27)13(2)3)28(34-35(29)15-6-7-15)23-19-11-32-12-20(19)23/h1,5,8-10,13,15,19-20,23,32,36H,6-7,11-12H2,2-3H3 ZGMAEZGKDREUBS-UHFFFAOYSA-N 373186 US20260022118, Example 74 GTPase NRas [G12D] 0.141 US Patent 10.7270/Q2SN0FTF US20260022118 NAGY, E; MANDAL, PK; JONES, P; SOTH, MJ; CROSS, JB; REYNA, NJ; COX, J; MCAFOOS, TJ; TRAN, TN 1/22/2026 6/3/2026 University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373186 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2110&target=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373186&enzyme=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 89739541 404342288 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDLPTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKKLNSSDDGTQGCMGLPCVVM 8TBI,3CON,9P46,6MQT,6MQG,421P,821P,1PLL,1PLJ,1JAI,1CLU,8UN3,8UN5,7L0G,8TLR,1PLK,1JAH,4L9W,4L9S GTPase NRas RASN_HUMAN P01111 Q14971 Q15104 Q15282 211168 C#Cc1c(F)ccc2cc(O)cc(-c3nc(N(C)C(C)C)c4c([C@H]5[C@@H]6CNC[C@@H]65)nn(C5CC5)c4c3F)c12 InChI=1S/C30H29F2N5O/c1-5-18-22(31)9-6-15-10-17(38)11-19(23(15)18)27-26(32)29-25(30(34-27)36(4)14(2)3)28(35-37(29)16-7-8-16)24-20-12-33-13-21(20)24/h1,6,9-11,14,16,20-21,24,33,38H,7-8,12-13H2,2-4H3 NXXZCLRHPOQUPP-UHFFFAOYSA-N 373188 US20260022118, Example 75 GTPase NRas [G12D] 25.0 US Patent 10.7270/Q2SN0FTF US20260022118 NAGY, E; MANDAL, PK; JONES, P; SOTH, MJ; CROSS, JB; REYNA, NJ; COX, J; MCAFOOS, TJ; TRAN, TN 1/22/2026 6/3/2026 University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373188 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2110&target=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373188&enzyme=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 71715332 404342290 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDLPTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKKLNSSDDGTQGCMGLPCVVM 8TBI,3CON,9P46,6MQT,6MQG,421P,821P,1PLL,1PLJ,1JAI,1CLU,8UN3,8UN5,7L0G,8TLR,1PLK,1JAH,4L9W,4L9S GTPase NRas RASN_HUMAN P01111 Q14971 Q15104 Q15282 211169 C#Cc1c(F)ccc2cc(O)cc(-c3nc(NC)c4c([C@H]5[C@@H]6CNC[C@@H]65)nn(C5CC5)c4c3F)c12 InChI=1S/C27H23F2N5O/c1-3-15-19(28)7-4-12-8-14(35)9-16(20(12)15)24-23(29)26-22(27(30-2)32-24)25(33-34(26)13-5-6-13)21-17-10-31-11-18(17)21/h1,4,7-9,13,17-18,21,31,35H,5-6,10-11H2,2H3,(H,30,32) QQECYIWSMCMEBV-UHFFFAOYSA-N 373189 US20260022118, Example 76 GTPase NRas [G12D] 28.3 US Patent 10.7270/Q2SN0FTF US20260022118 NAGY, E; MANDAL, PK; JONES, P; SOTH, MJ; CROSS, JB; REYNA, NJ; COX, J; MCAFOOS, TJ; TRAN, TN 1/22/2026 6/3/2026 University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373189 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2110&target=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373189&enzyme=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 71715333 404342291 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDLPTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKKLNSSDDGTQGCMGLPCVVM 8TBI,3CON,9P46,6MQT,6MQG,421P,821P,1PLL,1PLJ,1JAI,1CLU,8UN3,8UN5,7L0G,8TLR,1PLK,1JAH,4L9W,4L9S GTPase NRas RASN_HUMAN P01111 Q14971 Q15104 Q15282 211170 C#Cc1c(F)ccc2cc(O)cc(-c3nc(NC(C)C)c4c([C@H]5[C@@H]6CNC[C@@H]65)nn(C5CC5)c4c3F)c12 InChI=1S/C29H27F2N5O/c1-4-17-21(30)8-5-14-9-16(37)10-18(22(14)17)26-25(31)28-24(29(34-26)33-13(2)3)27(35-36(28)15-6-7-15)23-19-11-32-12-20(19)23/h1,5,8-10,13,15,19-20,23,32,37H,6-7,11-12H2,2-3H3,(H,33,34) HRNJHFOFOJFPAS-UHFFFAOYSA-N 373190 US20260022118, Example 77 GTPase NRas [G12D] 17.9 US Patent 10.7270/Q2SN0FTF US20260022118 NAGY, E; MANDAL, PK; JONES, P; SOTH, MJ; CROSS, JB; REYNA, NJ; COX, J; MCAFOOS, TJ; TRAN, TN 1/22/2026 6/3/2026 University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373190 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2110&target=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373190&enzyme=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 71715334 404342292 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDLPTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKKLNSSDDGTQGCMGLPCVVM 8TBI,3CON,9P46,6MQT,6MQG,421P,821P,1PLL,1PLJ,1JAI,1CLU,8UN3,8UN5,7L0G,8TLR,1PLK,1JAH,4L9W,4L9S GTPase NRas RASN_HUMAN P01111 Q14971 Q15104 Q15282 211171 C#Cc1c(F)ccc2cc(O)cc(-c3nc(Nc4ccccc4)c4c([C@H]5[C@@H]6CNC[C@@H]65)nn(C5CC5)c4c3F)c12 InChI=1S/C32H25F2N5O/c1-2-20-24(33)11-8-16-12-19(40)13-21(25(16)20)29-28(34)31-27(32(37-29)36-17-6-4-3-5-7-17)30(38-39(31)18-9-10-18)26-22-14-35-15-23(22)26/h1,3-8,11-13,18,22-23,26,35,40H,9-10,14-15H2,(H,36,37) ILUDEJATZGCCLY-UHFFFAOYSA-N 373191 US20260022118, Example 83 GTPase NRas [G12D] 49.5 US Patent 10.7270/Q2SN0FTF US20260022118 NAGY, E; MANDAL, PK; JONES, P; SOTH, MJ; CROSS, JB; REYNA, NJ; COX, J; MCAFOOS, TJ; TRAN, TN 1/22/2026 6/3/2026 University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373191 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2110&target=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373191&enzyme=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 71715335 404342293 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDLPTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKKLNSSDDGTQGCMGLPCVVM 8TBI,3CON,9P46,6MQT,6MQG,421P,821P,1PLL,1PLJ,1JAI,1CLU,8UN3,8UN5,7L0G,8TLR,1PLK,1JAH,4L9W,4L9S GTPase NRas RASN_HUMAN P01111 Q14971 Q15104 Q15282 211172 C#Cc1c(F)ccc2cc(O)cc(-c3nc(C(C)=O)c4c([C@H]5[C@@H]6CNC[C@@H]65)nn(C5CC5)c4c3F)c12 InChI=1S/C28H22F2N4O2/c1-3-16-20(29)7-4-13-8-15(36)9-17(21(13)16)26-24(30)28-23(25(32-26)12(2)35)27(33-34(28)14-5-6-14)22-18-10-31-11-19(18)22/h1,4,7-9,14,18-19,22,31,36H,5-6,10-11H2,2H3 UAFWLVWMLYGVQU-UHFFFAOYSA-N 373192 US20260022118, Example 84 GTPase NRas [G12D] 119 US Patent 10.7270/Q2SN0FTF US20260022118 NAGY, E; MANDAL, PK; JONES, P; SOTH, MJ; CROSS, JB; REYNA, NJ; COX, J; MCAFOOS, TJ; TRAN, TN 1/22/2026 6/3/2026 University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373192 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2110&target=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373192&enzyme=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 89739846 404342294 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDLPTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKKLNSSDDGTQGCMGLPCVVM 8TBI,3CON,9P46,6MQT,6MQG,421P,821P,1PLL,1PLJ,1JAI,1CLU,8UN3,8UN5,7L0G,8TLR,1PLK,1JAH,4L9W,4L9S GTPase NRas RASN_HUMAN P01111 Q14971 Q15104 Q15282 211173 C#Cc1c(F)ccc2cc(O)cc(-c3ncc4c(N5CC6CCC(C5)N6)cn(C5CC5)c4c3F)c12 InChI=1S/C28H24F2N4O/c1-2-20-23(29)8-3-15-9-19(35)10-21(25(15)20)27-26(30)28-22(11-31-27)24(14-34(28)18-6-7-18)33-12-16-4-5-17(13-33)32-16/h1,3,8-11,14,16-18,32,35H,4-7,12-13H2 VJFVCSGFTFTBHA-UHFFFAOYSA-N 373193 US20260022118, Example 85 GTPase NRas [G12D] 336 US Patent 10.7270/Q2SN0FTF US20260022118 NAGY, E; MANDAL, PK; JONES, P; SOTH, MJ; CROSS, JB; REYNA, NJ; COX, J; MCAFOOS, TJ; TRAN, TN 1/22/2026 6/3/2026 University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373193 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2110&target=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373193&enzyme=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 89739505 404342295 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDLPTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKKLNSSDDGTQGCMGLPCVVM 8TBI,3CON,9P46,6MQT,6MQG,421P,821P,1PLL,1PLJ,1JAI,1CLU,8UN3,8UN5,7L0G,8TLR,1PLK,1JAH,4L9W,4L9S GTPase NRas RASN_HUMAN P01111 Q14971 Q15104 Q15282 211174 C#Cc1c(F)ccc2cc(O)cc(-c3ncc4c(N5C[C@@H]6CC[C@H]5CN6)cn(C5CC5)c4c3F)c12 InChI=1S/C28H24F2N4O/c1-2-20-23(29)8-3-15-9-19(35)10-21(25(15)20)27-26(30)28-22(12-32-27)24(14-34(28)17-6-7-17)33-13-16-4-5-18(33)11-31-16/h1,3,8-10,12,14,16-18,31,35H,4-7,11,13H2 BZFKRWLSLCWJDS-UHFFFAOYSA-N 373194 US20260022118, Example 86 GTPase NRas [G12D] 151 US Patent 10.7270/Q2SN0FTF US20260022118 NAGY, E; MANDAL, PK; JONES, P; SOTH, MJ; CROSS, JB; REYNA, NJ; COX, J; MCAFOOS, TJ; TRAN, TN 1/22/2026 6/3/2026 University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373194 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2110&target=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373194&enzyme=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 71715389 404342296 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDLPTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKKLNSSDDGTQGCMGLPCVVM 8TBI,3CON,9P46,6MQT,6MQG,421P,821P,1PLL,1PLJ,1JAI,1CLU,8UN3,8UN5,7L0G,8TLR,1PLK,1JAH,4L9W,4L9S GTPase NRas RASN_HUMAN P01111 Q14971 Q15104 Q15282 211175 C#Cc1c(F)ccc2cc(N)cc(-c3nc(CC)c4c([C@H]5[C@@H]6CNC[C@@H]65)nn(C5CC5)c4c3F)c12 InChI=1S/C28H25F2N5/c1-3-16-20(29)8-5-13-9-14(31)10-17(22(13)16)26-25(30)28-24(21(4-2)33-26)27(34-35(28)15-6-7-15)23-18-11-32-12-19(18)23/h1,5,8-10,15,18-19,23,32H,4,6-7,11-12,31H2,2H3 JBIFQXPOIYQCQV-UHFFFAOYSA-N 373195 US20260022118, Example 88 GTPase NRas [G12D] 4.58 US Patent 10.7270/Q2SN0FTF US20260022118 NAGY, E; MANDAL, PK; JONES, P; SOTH, MJ; CROSS, JB; REYNA, NJ; COX, J; MCAFOOS, TJ; TRAN, TN 1/22/2026 6/3/2026 University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373195 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2110&target=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373195&enzyme=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 71715390 404342297 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDLPTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKKLNSSDDGTQGCMGLPCVVM 8TBI,3CON,9P46,6MQT,6MQG,421P,821P,1PLL,1PLJ,1JAI,1CLU,8UN3,8UN5,7L0G,8TLR,1PLK,1JAH,4L9W,4L9S GTPase NRas RASN_HUMAN P01111 Q14971 Q15104 Q15282 211176 C#Cc1c(F)ccc2cc(O)cc(-c3nc(CC)c4c(N5C[C@@H]6CC[C@H]5CN6)nn(C5CC5)c4c3F)c12 InChI=1S/C29H27F2N5O/c1-3-20-22(30)10-5-15-11-19(37)12-21(24(15)20)27-26(31)28-25(23(4-2)33-27)29(34-36(28)17-8-9-17)35-14-16-6-7-18(35)13-32-16/h1,5,10-12,16-18,32,37H,4,6-9,13-14H2,2H3 VDVCTVNTTQWZNE-UHFFFAOYSA-N 373196 US20260022118, Example 90 GTPase NRas [G12D] 107 US Patent 10.7270/Q2SN0FTF US20260022118 NAGY, E; MANDAL, PK; JONES, P; SOTH, MJ; CROSS, JB; REYNA, NJ; COX, J; MCAFOOS, TJ; TRAN, TN 1/22/2026 6/3/2026 University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373196 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2110&target=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373196&enzyme=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 71715391 404342298 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDLPTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKKLNSSDDGTQGCMGLPCVVM 8TBI,3CON,9P46,6MQT,6MQG,421P,821P,1PLL,1PLJ,1JAI,1CLU,8UN3,8UN5,7L0G,8TLR,1PLK,1JAH,4L9W,4L9S GTPase NRas RASN_HUMAN P01111 Q14971 Q15104 Q15282 211177 C#Cc1c(F)ccc2cc(O)cc(-c3nc(OC)c4c(N5C[C@@H]6CC[C@H]5CN6)nn(C5CC5)c4c3F)c12 InChI=1S/C28H25F2N5O2/c1-3-19-21(29)9-4-14-10-18(36)11-20(22(14)19)25-24(30)26-23(28(32-25)37-2)27(33-35(26)16-7-8-16)34-13-15-5-6-17(34)12-31-15/h1,4,9-11,15-17,31,36H,5-8,12-13H2,2H3 JLIQBYLBURSYGF-UHFFFAOYSA-N 373197 US20260022118, Example 91 GTPase NRas [G12D] 146 US Patent 10.7270/Q2SN0FTF US20260022118 NAGY, E; MANDAL, PK; JONES, P; SOTH, MJ; CROSS, JB; REYNA, NJ; COX, J; MCAFOOS, TJ; TRAN, TN 1/22/2026 6/3/2026 University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373197 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2110&target=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373197&enzyme=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 71715445 404342299 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDLPTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKKLNSSDDGTQGCMGLPCVVM 8TBI,3CON,9P46,6MQT,6MQG,421P,821P,1PLL,1PLJ,1JAI,1CLU,8UN3,8UN5,7L0G,8TLR,1PLK,1JAH,4L9W,4L9S GTPase NRas RASN_HUMAN P01111 Q14971 Q15104 Q15282 211178 C#Cc1c(F)ccc2cc(O)cc(-c3ncc4c([C@H]5[C@@H]6CNC(C(=O)OC)[C@@H]65)nn(C)c4c3F)c12 InChI=1S/C26H20F2N4O3/c1-4-13-17(27)6-5-11-7-12(33)8-14(18(11)13)23-21(28)25-16(10-29-23)22(31-32(25)2)19-15-9-30-24(20(15)19)26(34)35-3/h1,5-8,10,15,19-20,24,30,33H,9H2,2-3H3 KGXHJSHRTPJUIR-UHFFFAOYSA-N 373198 methyl (1S,5R,6S)-6-(6-(8-ethynyl-7-fluoro-3- hydroxynaphthalen-1-yl)-7-fluoro-1-methyl- 1H-pyrazolo[4,3-c]pyridin-3-yl)-3- azabicyclo[3.1.0]hexane-2-carboxylate::US20260022118, Example 96 GTPase NRas [G12D] 904 US Patent 10.7270/Q2SN0FTF US20260022118 NAGY, E; MANDAL, PK; JONES, P; SOTH, MJ; CROSS, JB; REYNA, NJ; COX, J; MCAFOOS, TJ; TRAN, TN 1/22/2026 6/3/2026 University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373198 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2110&target=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373198&enzyme=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 77913180 404342300 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDLPTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKKLNSSDDGTQGCMGLPCVVM 8TBI,3CON,9P46,6MQT,6MQG,421P,821P,1PLL,1PLJ,1JAI,1CLU,8UN3,8UN5,7L0G,8TLR,1PLK,1JAH,4L9W,4L9S GTPase NRas RASN_HUMAN P01111 Q14971 Q15104 Q15282 211179 C#Cc1c(F)ccc2cc(O)cc(-c3ncc4c([C@H]5[C@@H]6CNC(CO)[C@@H]65)nn(C)c4c3F)c12 InChI=1S/C25H20F2N4O2/c1-3-13-17(26)5-4-11-6-12(33)7-14(19(11)13)24-22(27)25-16(9-29-24)23(30-31(25)2)21-15-8-28-18(10-32)20(15)21/h1,4-7,9,15,18,20-21,28,32-33H,8,10H2,2H3 YRONVIHNADRKSI-UHFFFAOYSA-N 373199 5-ethynyl-6-fluoro-4-(7-fluoro-3-((1S,5R,6S)-2- (hydroxymethyl)-3-azabicyclo[3.1.0]hexan-6- yl)-1-methyl-1H-pyrazolo[4,3-c]pyridin-6- yl)naphthalen-2-ol::US20260022118, Example 97 GTPase NRas [G12D] 190 US Patent 10.7270/Q2SN0FTF US20260022118 NAGY, E; MANDAL, PK; JONES, P; SOTH, MJ; CROSS, JB; REYNA, NJ; COX, J; MCAFOOS, TJ; TRAN, TN 1/22/2026 6/3/2026 University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373199 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2110&target=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373199&enzyme=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 71715447 404342301 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDLPTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKKLNSSDDGTQGCMGLPCVVM 8TBI,3CON,9P46,6MQT,6MQG,421P,821P,1PLL,1PLJ,1JAI,1CLU,8UN3,8UN5,7L0G,8TLR,1PLK,1JAH,4L9W,4L9S GTPase NRas RASN_HUMAN P01111 Q14971 Q15104 Q15282 211180 C#Cc1c(F)ccc2cc(O)cc(-c3nc(OCC(C)C)c4c([C@H]5[C@@H]6CNC[C@@H]65)nn(C5CC5)c4c3F)c12 InChI=1S/C30H28F2N4O2/c1-4-18-22(31)8-5-15-9-17(37)10-19(23(15)18)27-26(32)29-25(30(34-27)38-13-14(2)3)28(35-36(29)16-6-7-16)24-20-11-33-12-21(20)24/h1,5,8-10,14,16,20-21,24,33,37H,6-7,11-13H2,2-3H3 MNEBKSNJUIXXEJ-UHFFFAOYSA-N 373200 4-(3-((1R,5S,6r)-3-azabicyclo[3.1.0]hexan-6- yl)-1-cyclopropyl-7-fluoro-4-isobutoxy-1H- pyrazolo[4,3-c]pyridin-6-yl)-5-ethynyl-6- fluoronaphthalen-2-ol::US20260022118, Example 100 GTPase NRas [G12D] 704 US Patent 10.7270/Q2SN0FTF US20260022118 NAGY, E; MANDAL, PK; JONES, P; SOTH, MJ; CROSS, JB; REYNA, NJ; COX, J; MCAFOOS, TJ; TRAN, TN 1/22/2026 6/3/2026 University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373200 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2110&target=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373200&enzyme=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 71715448 404342302 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDLPTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKKLNSSDDGTQGCMGLPCVVM 8TBI,3CON,9P46,6MQT,6MQG,421P,821P,1PLL,1PLJ,1JAI,1CLU,8UN3,8UN5,7L0G,8TLR,1PLK,1JAH,4L9W,4L9S GTPase NRas RASN_HUMAN P01111 Q14971 Q15104 Q15282 211181 C#Cc1c(F)ccc2cc(O)cc(-c3ncc4c([C@H]5[C@@H]6CNC[C@@H]65)nn(CCCN(C)C)c4c3F)c12 InChI=1S/C28H27F2N5O/c1-4-17-22(29)7-6-15-10-16(36)11-18(23(15)17)27-25(30)28-21(14-32-27)26(24-19-12-31-13-20(19)24)33-35(28)9-5-8-34(2)3/h1,6-7,10-11,14,19-20,24,31,36H,5,8-9,12-13H2,2-3H3 KQDQITGOVSGYFT-UHFFFAOYSA-N 373201 4-(3-((1R,5S,6r)-3-azabicyclo[3.1.0]hexan-6- yl)-1-(3-(dimethylamino)propyl)-7-fluoro-1H- pyrazolo[4,3-c]pyridin-6-yl)-5-ethynyl-6- fluoronaphthalen-2-ol::US20260022118, Example 102 GTPase NRas [G12D] 7600 US Patent 10.7270/Q2SN0FTF US20260022118 NAGY, E; MANDAL, PK; JONES, P; SOTH, MJ; CROSS, JB; REYNA, NJ; COX, J; MCAFOOS, TJ; TRAN, TN 1/22/2026 6/3/2026 University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373201 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2110&target=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373201&enzyme=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 71715446 404342303 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDLPTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKKLNSSDDGTQGCMGLPCVVM 8TBI,3CON,9P46,6MQT,6MQG,421P,821P,1PLL,1PLJ,1JAI,1CLU,8UN3,8UN5,7L0G,8TLR,1PLK,1JAH,4L9W,4L9S GTPase NRas RASN_HUMAN P01111 Q14971 Q15104 Q15282 211182 C#Cc1c(F)ccc2cc(O)cc(-c3ncc4c(C5[C@H]6CNC[C@@H]56)cn(CCO)c4c3F)c12 InChI=1S/C26H21F2N3O2/c1-2-15-21(27)4-3-13-7-14(33)8-16(22(13)15)25-24(28)26-19(11-30-25)20(12-31(26)5-6-32)23-17-9-29-10-18(17)23/h1,3-4,7-8,11-12,17-18,23,29,32-33H,5-6,9-10H2 XYBUCUBETYKEHF-UHFFFAOYSA-N 373203 4-(3-((1R,5S)-3-azabicyclo[3.1.0]hexan-6-yl)- 7-fluoro-1-(2-hydroxyethyl)-1H-pyrrolo[3,2- c]pyridin-6-yl)-5-ethynyl-6-fluoronaphthalen-2- ol::US20260022118, Example 103 GTPase NRas [G12D] 488 US Patent 10.7270/Q2SN0FTF US20260022118 NAGY, E; MANDAL, PK; JONES, P; SOTH, MJ; CROSS, JB; REYNA, NJ; COX, J; MCAFOOS, TJ; TRAN, TN 1/22/2026 6/3/2026 University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373203 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2110&target=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373203&enzyme=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 89739395 404342305 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDLPTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKKLNSSDDGTQGCMGLPCVVM 8TBI,3CON,9P46,6MQT,6MQG,421P,821P,1PLL,1PLJ,1JAI,1CLU,8UN3,8UN5,7L0G,8TLR,1PLK,1JAH,4L9W,4L9S GTPase NRas RASN_HUMAN P01111 Q14971 Q15104 Q15282 211183 C#Cc1c(F)ccc2cc(O)cc(-c3ncc4c([C@H]5[C@@H]6CNC[C@@H]65)nn([C@@H]5C[C@@H]5C)c4c3F)c12 InChI=1S/C27H22F2N4O/c1-3-15-20(28)5-4-13-7-14(34)8-16(22(13)15)26-24(29)27-19(11-31-26)25(23-17-9-30-10-18(17)23)32-33(27)21-6-12(21)2/h1,4-5,7-8,11-12,17-18,21,23,30,34H,6,9-10H2,2H3 PICRQQSUAAUHNR-UHFFFAOYSA-N 373204 4-(3-((1R,5S,6r)-3-azabicyclo[3.1.0]hexan-6- yl)-7-fluoro-1-((1R,2S)-2-methylcyclopropyl)- 1H-pyrazolo[4,3-c]pyridin-6-yl)-5-ethynyl-6- fluoronaphthalen-2-ol::US20260022118, Example 104 GTPase NRas [G12D] 1170 US Patent 10.7270/Q2SN0FTF US20260022118 NAGY, E; MANDAL, PK; JONES, P; SOTH, MJ; CROSS, JB; REYNA, NJ; COX, J; MCAFOOS, TJ; TRAN, TN 1/22/2026 6/3/2026 University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373204 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2110&target=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373204&enzyme=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 71715499 404342306 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDLPTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKKLNSSDDGTQGCMGLPCVVM 8TBI,3CON,9P46,6MQT,6MQG,421P,821P,1PLL,1PLJ,1JAI,1CLU,8UN3,8UN5,7L0G,8TLR,1PLK,1JAH,4L9W,4L9S GTPase NRas RASN_HUMAN P01111 Q14971 Q15104 Q15282 211184 C#Cc1c(F)ccc2cc(O)cc(-c3ncc4c(N5CC6CCC5CN6)nn(C5CC5)c4c3F)c12 InChI=1S/C27H23F2N5O/c1-2-19-22(28)8-3-14-9-18(35)10-20(23(14)19)25-24(29)26-21(12-31-25)27(32-34(26)16-6-7-16)33-13-15-4-5-17(33)11-30-15/h1,3,8-10,12,15-17,30,35H,4-7,11,13H2 KHIXLLWESRIMRA-UHFFFAOYSA-N 373205 4-(3-(2,5-diazabicyclo[2.2.2]octan-2-yl)-1- cyclopropyl-7-fluoro-1H-pyrazolo[4,3- c]pyridin-6-yl)-5-ethynyl-6-fluoronaphthalen-2- ol::US20260022118, Example 105 GTPase NRas [G12D] 18.5 US Patent 10.7270/Q2SN0FTF US20260022118 NAGY, E; MANDAL, PK; JONES, P; SOTH, MJ; CROSS, JB; REYNA, NJ; COX, J; MCAFOOS, TJ; TRAN, TN 1/22/2026 6/3/2026 University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373205 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2110&target=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373205&enzyme=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 71715500 404342307 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDLPTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKKLNSSDDGTQGCMGLPCVVM 8TBI,3CON,9P46,6MQT,6MQG,421P,821P,1PLL,1PLJ,1JAI,1CLU,8UN3,8UN5,7L0G,8TLR,1PLK,1JAH,4L9W,4L9S GTPase NRas RASN_HUMAN P01111 Q14971 Q15104 Q15282 211185 C#Cc1c(F)ccc2cc(O)cc(-c3ncc4c(N5C[C@@H]6CC[C@H]5CN6)nn(C5CC5)c4c3F)c12 InChI=1S/C27H23F2N5O/c1-2-19-22(28)8-3-14-9-18(35)10-20(23(14)19)25-24(29)26-21(12-31-25)27(32-34(26)16-6-7-16)33-13-15-4-5-17(33)11-30-15/h1,3,8-10,12,15-17,30,35H,4-7,11,13H2 KHIXLLWESRIMRA-UHFFFAOYSA-N 373206 4-(3-((1S,4S)-2,5-diazabicyclo[2.2.2]octan-2- yl)-1-cyclopropyl-7-fluoro-1H-pyrazolo[4,3- c]pyridin-6-yl)-5-ethynyl-6-fluoronaphthalen-2- ol::US20260022118, Example 106 GTPase NRas [G12D] 9.39 US Patent 10.7270/Q2SN0FTF US20260022118 NAGY, E; MANDAL, PK; JONES, P; SOTH, MJ; CROSS, JB; REYNA, NJ; COX, J; MCAFOOS, TJ; TRAN, TN 1/22/2026 6/3/2026 University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373206 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2110&target=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373206&enzyme=GTPase+NRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 71715501 404342308 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDLPTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKKLNSSDDGTQGCMGLPCVVM 8TBI,3CON,9P46,6MQT,6MQG,421P,821P,1PLL,1PLJ,1JAI,1CLU,8UN3,8UN5,7L0G,8TLR,1PLK,1JAH,4L9W,4L9S GTPase NRas RASN_HUMAN P01111 Q14971 Q15104 Q15282