BindingDB Reactant_set_id	Ligand SMILES	Ligand InChI	Ligand InChI Key	BindingDB MonomerID	BindingDB Ligand Name	Target Name	Target Source Organism According to Curator or DataSource	Ki (nM)	IC50 (nM)	Kd (nM)	EC50 (nM)	kon (M-1-s-1)	koff (s-1)	pH	Temp (C)	Curation/DataSource	Article DOI	BindingDB Entry DOI	PMID	PubChem AID	Patent Number	Authors	Date of publication	Date in BindingDB	Institution	Link to Ligand in BindingDB	Link to Target in BindingDB	Link to Ligand-Target Pair in BindingDB	Ligand HET ID in PDB	PDB ID(s) for Ligand-Target Complex	PubChem CID	PubChem SID	ChEBI ID of Ligand	ChEMBL ID of Ligand	DrugBank ID of Ligand	IUPHAR_GRAC ID of Ligand	KEGG ID of Ligand	ZINC ID of Ligand	Number of Protein Chains in Target (>1 implies a multichain complex)	BindingDB Target Chain Sequence 1	PDB ID(s) of Target Chain 1	UniProt (SwissProt) Recommended Name of Target Chain 1	UniProt (SwissProt) Entry Name of Target Chain 1	UniProt (SwissProt) Primary ID of Target Chain 1	UniProt (SwissProt) Secondary ID(s) of Target Chain 1	UniProt (SwissProt) Alternative ID(s) of Target Chain 1	UniProt (TrEMBL) Submitted Name of Target Chain 1	UniProt (TrEMBL) Entry Name of Target Chain 1	UniProt (TrEMBL) Primary ID of Target Chain 1	UniProt (TrEMBL) Secondary ID(s) of Target Chain 1	UniProt (TrEMBL) Alternative ID(s) of Target Chain 1	BindingDB Target Chain Sequence 2	PDB ID(s) of Target Chain 2	UniProt (SwissProt) Recommended Name of Target Chain 2	UniProt (SwissProt) Entry Name of Target Chain 2	UniProt (SwissProt) Primary ID of Target Chain 2	UniProt (SwissProt) Secondary ID(s) of Target Chain 2	UniProt (SwissProt) Alternative ID(s) of Target Chain 2	UniProt (TrEMBL) Submitted Name of Target Chain 2	UniProt (TrEMBL) Entry Name of Target Chain 2	UniProt (TrEMBL) Primary ID of Target Chain 2	UniProt (TrEMBL) Secondary ID(s) of Target Chain 2	UniProt (TrEMBL) Alternative ID(s) of Target Chain 2	BindingDB Target Chain Sequence 3	PDB ID(s) of Target Chain 3	UniProt (SwissProt) Recommended Name of Target Chain 3	UniProt (SwissProt) Entry Name of Target Chain 3	UniProt (SwissProt) Primary ID of Target Chain 3	UniProt (SwissProt) Secondary ID(s) of Target Chain 3	UniProt (SwissProt) Alternative ID(s) of Target Chain 3	UniProt (TrEMBL) Submitted Name of Target Chain 3	UniProt (TrEMBL) Entry Name of Target Chain 3	UniProt (TrEMBL) Primary ID of Target Chain 3	UniProt (TrEMBL) Secondary ID(s) of Target Chain 3	UniProt (TrEMBL) Alternative ID(s) of Target Chain 3	BindingDB Target Chain Sequence 4	PDB ID(s) of Target Chain 4	UniProt (SwissProt) Recommended Name of Target Chain 4	UniProt (SwissProt) Entry Name of Target Chain 4	UniProt (SwissProt) Primary ID of Target Chain 4	UniProt (SwissProt) Secondary ID(s) of Target Chain 4	UniProt (SwissProt) Alternative ID(s) of Target Chain 4	UniProt (TrEMBL) Submitted Name of Target Chain 4	UniProt (TrEMBL) Entry Name of Target Chain 4	UniProt (TrEMBL) Primary ID of Target Chain 4	UniProt (TrEMBL) Secondary ID(s) of Target Chain 4	UniProt (TrEMBL) Alternative ID(s) of Target Chain 4	BindingDB Target Chain Sequence 5	PDB ID(s) of Target Chain 5	UniProt (SwissProt) Recommended Name of Target Chain 5	UniProt (SwissProt) Entry Name of Target Chain 5	UniProt (SwissProt) Primary ID of Target Chain 5	UniProt (SwissProt) Secondary ID(s) of Target Chain 5	UniProt (SwissProt) Alternative ID(s) of Target Chain 5	UniProt (TrEMBL) Submitted Name of Target Chain 5	UniProt (TrEMBL) Entry Name of Target Chain 5	UniProt (TrEMBL) Primary ID of Target Chain 5	UniProt (TrEMBL) Secondary ID(s) of Target Chain 5	UniProt (TrEMBL) Alternative ID(s) of Target Chain 5	BindingDB Target Chain Sequence 6	PDB ID(s) of Target Chain 6	UniProt (SwissProt) Recommended Name of Target Chain 6	UniProt (SwissProt) Entry Name of Target Chain 6	UniProt (SwissProt) Primary ID of Target Chain 6	UniProt (SwissProt) Secondary ID(s) of Target Chain 6	UniProt (SwissProt) Alternative ID(s) of Target Chain 6	UniProt (TrEMBL) Submitted Name of Target Chain 6	UniProt (TrEMBL) Entry Name of Target Chain 6	UniProt (TrEMBL) Primary ID of Target Chain 6	UniProt (TrEMBL) Secondary ID(s) of Target Chain 6	UniProt (TrEMBL) Alternative ID(s) of Target Chain 6	BindingDB Target Chain Sequence 7	PDB ID(s) of Target Chain 7	UniProt (SwissProt) Recommended Name of Target Chain 7	UniProt (SwissProt) Entry Name of Target Chain 7	UniProt (SwissProt) Primary ID of Target Chain 7	UniProt (SwissProt) Secondary ID(s) of Target Chain 7	UniProt (SwissProt) Alternative ID(s) of Target Chain 7	UniProt (TrEMBL) Submitted Name of Target Chain 7	UniProt (TrEMBL) Entry Name of Target Chain 7	UniProt (TrEMBL) Primary ID of Target Chain 7	UniProt (TrEMBL) Secondary ID(s) of Target Chain 7	UniProt (TrEMBL) Alternative ID(s) of Target Chain 7	BindingDB Target Chain Sequence 8	PDB ID(s) of Target Chain 8	UniProt (SwissProt) Recommended Name of Target Chain 8	UniProt (SwissProt) Entry Name of Target Chain 8	UniProt (SwissProt) Primary ID of Target Chain 8	UniProt (SwissProt) Secondary ID(s) of Target Chain 8	UniProt (SwissProt) Alternative ID(s) of Target Chain 8	UniProt (TrEMBL) Submitted Name of Target Chain 8	UniProt (TrEMBL) Entry Name of Target Chain 8	UniProt (TrEMBL) Primary ID of Target Chain 8	UniProt (TrEMBL) Secondary ID(s) of Target Chain 8	UniProt (TrEMBL) Alternative ID(s) of Target Chain 8	BindingDB Target Chain Sequence 9	PDB ID(s) of Target Chain 9	UniProt (SwissProt) Recommended Name of Target Chain 9	UniProt (SwissProt) Entry Name of Target Chain 9	UniProt (SwissProt) Primary ID of Target Chain 9	UniProt (SwissProt) Secondary ID(s) of Target Chain 9	UniProt (SwissProt) Alternative ID(s) of Target Chain 9	UniProt (TrEMBL) Submitted Name of Target Chain 9	UniProt (TrEMBL) Entry Name of Target Chain 9	UniProt (TrEMBL) Primary ID of Target Chain 9	UniProt (TrEMBL) Secondary ID(s) of Target Chain 9	UniProt (TrEMBL) Alternative ID(s) of Target Chain 9	BindingDB Target Chain Sequence 10	PDB ID(s) of Target Chain 10	UniProt (SwissProt) Recommended Name of Target Chain 10	UniProt (SwissProt) Entry Name of Target Chain 10	UniProt (SwissProt) Primary ID of Target Chain 10	UniProt (SwissProt) Secondary ID(s) of Target Chain 10	UniProt (SwissProt) Alternative ID(s) of Target Chain 10	UniProt (TrEMBL) Submitted Name of Target Chain 10	UniProt (TrEMBL) Entry Name of Target Chain 10	UniProt (TrEMBL) Primary ID of Target Chain 10	UniProt (TrEMBL) Secondary ID(s) of Target Chain 10	UniProt (TrEMBL) Alternative ID(s) of Target Chain 10	BindingDB Target Chain Sequence 11	PDB ID(s) of Target Chain 11	UniProt (SwissProt) Recommended Name of Target Chain 11	UniProt (SwissProt) Entry Name of Target Chain 11	UniProt (SwissProt) Primary ID of Target Chain 11	UniProt (SwissProt) Secondary ID(s) of Target Chain 11	UniProt (SwissProt) Alternative ID(s) of Target Chain 11	UniProt (TrEMBL) Submitted Name of Target Chain 11	UniProt (TrEMBL) Entry Name of Target Chain 11	UniProt (TrEMBL) Primary ID of Target Chain 11	UniProt (TrEMBL) Secondary ID(s) of Target Chain 11	UniProt (TrEMBL) Alternative ID(s) of Target Chain 11	BindingDB Target Chain Sequence 12	PDB ID(s) of Target Chain 12	UniProt (SwissProt) Recommended Name of Target Chain 12	UniProt (SwissProt) Entry Name of Target Chain 12	UniProt (SwissProt) Primary ID of Target Chain 12	UniProt (SwissProt) Secondary ID(s) of Target Chain 12	UniProt (SwissProt) Alternative ID(s) of Target Chain 12	UniProt (TrEMBL) Submitted Name of Target Chain 12	UniProt (TrEMBL) Entry Name of Target Chain 12	UniProt (TrEMBL) Primary ID of Target Chain 12	UniProt (TrEMBL) Secondary ID(s) of Target Chain 12	UniProt (TrEMBL) Alternative ID(s) of Target Chain 12	BindingDB Target Chain Sequence 13	PDB ID(s) of Target Chain 13	UniProt (SwissProt) Recommended Name of Target Chain 13	UniProt (SwissProt) Entry Name of Target Chain 13	UniProt (SwissProt) Primary ID of Target Chain 13	UniProt (SwissProt) Secondary ID(s) of Target Chain 13	UniProt (SwissProt) Alternative ID(s) of Target Chain 13	UniProt (TrEMBL) Submitted Name of Target Chain 13	UniProt (TrEMBL) Entry Name of Target Chain 13	UniProt (TrEMBL) Primary ID of Target Chain 13	UniProt (TrEMBL) Secondary ID(s) of Target Chain 13	UniProt (TrEMBL) Alternative ID(s) of Target Chain 13	BindingDB Target Chain Sequence 14	PDB ID(s) of Target Chain 14	UniProt (SwissProt) Recommended Name of Target Chain 14	UniProt (SwissProt) Entry Name of Target Chain 14	UniProt (SwissProt) Primary ID of Target Chain 14	UniProt (SwissProt) Secondary ID(s) of Target Chain 14	UniProt (SwissProt) Alternative ID(s) of Target Chain 14	UniProt (TrEMBL) Submitted Name of Target Chain 14	UniProt (TrEMBL) Entry Name of Target Chain 14	UniProt (TrEMBL) Primary ID of Target Chain 14	UniProt (TrEMBL) Secondary ID(s) of Target Chain 14	UniProt (TrEMBL) Alternative ID(s) of Target Chain 14	BindingDB Target Chain Sequence 15	PDB ID(s) of Target Chain 15	UniProt (SwissProt) Recommended Name of Target Chain 15	UniProt (SwissProt) Entry Name of Target Chain 15	UniProt (SwissProt) Primary ID of Target Chain 15	UniProt (SwissProt) Secondary ID(s) of Target Chain 15	UniProt (SwissProt) Alternative ID(s) of Target Chain 15	UniProt (TrEMBL) Submitted Name of Target Chain 15	UniProt (TrEMBL) Entry Name of Target Chain 15	UniProt (TrEMBL) Primary ID of Target Chain 15	UniProt (TrEMBL) Secondary ID(s) of Target Chain 15	UniProt (TrEMBL) Alternative ID(s) of Target Chain 15	BindingDB Target Chain Sequence 16	PDB ID(s) of Target Chain 16	UniProt (SwissProt) Recommended Name of Target Chain 16	UniProt (SwissProt) Entry Name of Target Chain 16	UniProt (SwissProt) Primary ID of Target Chain 16	UniProt (SwissProt) Secondary ID(s) of Target Chain 16	UniProt (SwissProt) Alternative ID(s) of Target Chain 16	UniProt (TrEMBL) Submitted Name of Target Chain 16	UniProt (TrEMBL) Entry Name of Target Chain 16	UniProt (TrEMBL) Primary ID of Target Chain 16	UniProt (TrEMBL) Secondary ID(s) of Target Chain 16	UniProt (TrEMBL) Alternative ID(s) of Target Chain 16	BindingDB Target Chain Sequence 17	PDB ID(s) of Target Chain 17	UniProt (SwissProt) Recommended Name of Target Chain 17	UniProt (SwissProt) Entry Name of Target Chain 17	UniProt (SwissProt) Primary ID of Target Chain 17	UniProt (SwissProt) Secondary ID(s) of Target Chain 17	UniProt (SwissProt) Alternative ID(s) of Target Chain 17	UniProt (TrEMBL) Submitted Name of Target Chain 17	UniProt (TrEMBL) Entry Name of Target Chain 17	UniProt (TrEMBL) Primary ID of Target Chain 17	UniProt (TrEMBL) Secondary ID(s) of Target Chain 17	UniProt (TrEMBL) Alternative ID(s) of Target Chain 17	BindingDB Target Chain Sequence 18	PDB ID(s) of Target Chain 18	UniProt (SwissProt) Recommended Name of Target Chain 18	UniProt (SwissProt) Entry Name of Target Chain 18	UniProt (SwissProt) Primary ID of Target Chain 18	UniProt (SwissProt) Secondary ID(s) of Target Chain 18	UniProt (SwissProt) Alternative ID(s) of Target Chain 18	UniProt (TrEMBL) Submitted Name of Target Chain 18	UniProt (TrEMBL) Entry Name of Target Chain 18	UniProt (TrEMBL) Primary ID of Target Chain 18	UniProt (TrEMBL) Secondary ID(s) of Target Chain 18	UniProt (TrEMBL) Alternative ID(s) of Target Chain 18	BindingDB Target Chain Sequence 19	PDB ID(s) of Target Chain 19	UniProt (SwissProt) Recommended Name of Target Chain 19	UniProt (SwissProt) Entry Name of Target Chain 19	UniProt (SwissProt) Primary ID of Target Chain 19	UniProt (SwissProt) Secondary ID(s) of Target Chain 19	UniProt (SwissProt) Alternative ID(s) of Target Chain 19	UniProt (TrEMBL) Submitted Name of Target Chain 19	UniProt (TrEMBL) Entry Name of Target Chain 19	UniProt (TrEMBL) Primary ID of Target Chain 19	UniProt (TrEMBL) Secondary ID(s) of Target Chain 19	UniProt (TrEMBL) Alternative ID(s) of Target Chain 19	BindingDB Target Chain Sequence 20	PDB ID(s) of Target Chain 20	UniProt (SwissProt) Recommended Name of Target Chain 20	UniProt (SwissProt) Entry Name of Target Chain 20	UniProt (SwissProt) Primary ID of Target Chain 20	UniProt (SwissProt) Secondary ID(s) of Target Chain 20	UniProt (SwissProt) Alternative ID(s) of Target Chain 20	UniProt (TrEMBL) Submitted Name of Target Chain 20	UniProt (TrEMBL) Entry Name of Target Chain 20	UniProt (TrEMBL) Primary ID of Target Chain 20	UniProt (TrEMBL) Secondary ID(s) of Target Chain 20	UniProt (TrEMBL) Alternative ID(s) of Target Chain 20	BindingDB Target Chain Sequence 21	PDB ID(s) of Target Chain 21	UniProt (SwissProt) Recommended Name of Target Chain 21	UniProt (SwissProt) Entry Name of Target Chain 21	UniProt (SwissProt) Primary ID of Target Chain 21	UniProt (SwissProt) Secondary ID(s) of Target Chain 21	UniProt (SwissProt) Alternative ID(s) of Target Chain 21	UniProt (TrEMBL) Submitted Name of Target Chain 21	UniProt (TrEMBL) Entry Name of Target Chain 21	UniProt (TrEMBL) Primary ID of Target Chain 21	UniProt (TrEMBL) Secondary ID(s) of Target Chain 21	UniProt (TrEMBL) Alternative ID(s) of Target Chain 21	BindingDB Target Chain Sequence 22	PDB ID(s) of Target Chain 22	UniProt (SwissProt) Recommended Name of Target Chain 22	UniProt (SwissProt) Entry Name of Target Chain 22	UniProt (SwissProt) Primary ID of Target Chain 22	UniProt (SwissProt) Secondary ID(s) of Target Chain 22	UniProt (SwissProt) Alternative ID(s) of Target Chain 22	UniProt (TrEMBL) Submitted Name of Target Chain 22	UniProt (TrEMBL) Entry Name of Target Chain 22	UniProt (TrEMBL) Primary ID of Target Chain 22	UniProt (TrEMBL) Secondary ID(s) of Target Chain 22	UniProt (TrEMBL) Alternative ID(s) of Target Chain 22	BindingDB Target Chain Sequence 23	PDB ID(s) of Target Chain 23	UniProt (SwissProt) Recommended Name of Target Chain 23	UniProt (SwissProt) Entry Name of Target Chain 23	UniProt (SwissProt) Primary ID of Target Chain 23	UniProt (SwissProt) Secondary ID(s) of Target Chain 23	UniProt (SwissProt) Alternative ID(s) of Target Chain 23	UniProt (TrEMBL) Submitted Name of Target Chain 23	UniProt (TrEMBL) Entry Name of Target Chain 23	UniProt (TrEMBL) Primary ID of Target Chain 23	UniProt (TrEMBL) Secondary ID(s) of Target Chain 23	UniProt (TrEMBL) Alternative ID(s) of Target Chain 23	BindingDB Target Chain Sequence 24	PDB ID(s) of Target Chain 24	UniProt (SwissProt) Recommended Name of Target Chain 24	UniProt (SwissProt) Entry Name of Target Chain 24	UniProt (SwissProt) Primary ID of Target Chain 24	UniProt (SwissProt) Secondary ID(s) of Target Chain 24	UniProt (SwissProt) Alternative ID(s) of Target Chain 24	UniProt (TrEMBL) Submitted Name of Target Chain 24	UniProt (TrEMBL) Entry Name of Target Chain 24	UniProt (TrEMBL) Primary ID of Target Chain 24	UniProt (TrEMBL) Secondary ID(s) of Target Chain 24	UniProt (TrEMBL) Alternative ID(s) of Target Chain 24	BindingDB Target Chain Sequence 25	PDB ID(s) of Target Chain 25	UniProt (SwissProt) Recommended Name of Target Chain 25	UniProt (SwissProt) Entry Name of Target Chain 25	UniProt (SwissProt) Primary ID of Target Chain 25	UniProt (SwissProt) Secondary ID(s) of Target Chain 25	UniProt (SwissProt) Alternative ID(s) of Target Chain 25	UniProt (TrEMBL) Submitted Name of Target Chain 25	UniProt (TrEMBL) Entry Name of Target Chain 25	UniProt (TrEMBL) Primary ID of Target Chain 25	UniProt (TrEMBL) Secondary ID(s) of Target Chain 25	UniProt (TrEMBL) Alternative ID(s) of Target Chain 25	BindingDB Target Chain Sequence 26	PDB ID(s) of Target Chain 26	UniProt (SwissProt) Recommended Name of Target Chain 26	UniProt (SwissProt) Entry Name of Target Chain 26	UniProt (SwissProt) Primary ID of Target Chain 26	UniProt (SwissProt) Secondary ID(s) of Target Chain 26	UniProt (SwissProt) Alternative ID(s) of Target Chain 26	UniProt (TrEMBL) Submitted Name of Target Chain 26	UniProt (TrEMBL) Entry Name of Target Chain 26	UniProt (TrEMBL) Primary ID of Target Chain 26	UniProt (TrEMBL) Secondary ID(s) of Target Chain 26	UniProt (TrEMBL) Alternative ID(s) of Target Chain 26	BindingDB Target Chain Sequence 27	PDB ID(s) of Target Chain 27	UniProt (SwissProt) Recommended Name of Target Chain 27	UniProt (SwissProt) Entry Name of Target Chain 27	UniProt (SwissProt) Primary ID of Target Chain 27	UniProt (SwissProt) Secondary ID(s) of Target Chain 27	UniProt (SwissProt) Alternative ID(s) of Target Chain 27	UniProt (TrEMBL) Submitted Name of Target Chain 27	UniProt (TrEMBL) Entry Name of Target Chain 27	UniProt (TrEMBL) Primary ID of Target Chain 27	UniProt (TrEMBL) Secondary ID(s) of Target Chain 27	UniProt (TrEMBL) Alternative ID(s) of Target Chain 27	BindingDB Target Chain Sequence 28	PDB ID(s) of Target Chain 28	UniProt (SwissProt) Recommended Name of Target Chain 28	UniProt (SwissProt) Entry Name of Target Chain 28	UniProt (SwissProt) Primary ID of Target Chain 28	UniProt (SwissProt) Secondary ID(s) of Target Chain 28	UniProt (SwissProt) Alternative ID(s) of Target Chain 28	UniProt (TrEMBL) Submitted Name of Target Chain 28	UniProt (TrEMBL) Entry Name of Target Chain 28	UniProt (TrEMBL) Primary ID of Target Chain 28	UniProt (TrEMBL) Secondary ID(s) of Target Chain 28	UniProt (TrEMBL) Alternative ID(s) of Target Chain 28	BindingDB Target Chain Sequence 29	PDB ID(s) of Target Chain 29	UniProt (SwissProt) Recommended Name of Target Chain 29	UniProt (SwissProt) Entry Name of Target Chain 29	UniProt (SwissProt) Primary ID of Target Chain 29	UniProt (SwissProt) Secondary ID(s) of Target Chain 29	UniProt (SwissProt) Alternative ID(s) of Target Chain 29	UniProt (TrEMBL) Submitted Name of Target Chain 29	UniProt (TrEMBL) Entry Name of Target Chain 29	UniProt (TrEMBL) Primary ID of Target Chain 29	UniProt (TrEMBL) Secondary ID(s) of Target Chain 29	UniProt (TrEMBL) Alternative ID(s) of Target Chain 29	BindingDB Target Chain Sequence 30	PDB ID(s) of Target Chain 30	UniProt (SwissProt) Recommended Name of Target Chain 30	UniProt (SwissProt) Entry Name of Target Chain 30	UniProt (SwissProt) Primary ID of Target Chain 30	UniProt (SwissProt) Secondary ID(s) of Target Chain 30	UniProt (SwissProt) Alternative ID(s) of Target Chain 30	UniProt (TrEMBL) Submitted Name of Target Chain 30	UniProt (TrEMBL) Entry Name of Target Chain 30	UniProt (TrEMBL) Primary ID of Target Chain 30	UniProt (TrEMBL) Secondary ID(s) of Target Chain 30	UniProt (TrEMBL) Alternative ID(s) of Target Chain 30	BindingDB Target Chain Sequence 31	PDB ID(s) of Target Chain 31	UniProt (SwissProt) Recommended Name of Target Chain 31	UniProt (SwissProt) Entry Name of Target Chain 31	UniProt (SwissProt) Primary ID of Target Chain 31	UniProt (SwissProt) Secondary ID(s) of Target Chain 31	UniProt (SwissProt) Alternative ID(s) of Target Chain 31	UniProt (TrEMBL) Submitted Name of Target Chain 31	UniProt (TrEMBL) Entry Name of Target Chain 31	UniProt (TrEMBL) Primary ID of Target Chain 31	UniProt (TrEMBL) Secondary ID(s) of Target Chain 31	UniProt (TrEMBL) Alternative ID(s) of Target Chain 31	BindingDB Target Chain Sequence 32	PDB ID(s) of Target Chain 32	UniProt (SwissProt) Recommended Name of Target Chain 32	UniProt (SwissProt) Entry Name of Target Chain 32	UniProt (SwissProt) Primary ID of Target Chain 32	UniProt (SwissProt) Secondary ID(s) of Target Chain 32	UniProt (SwissProt) Alternative ID(s) of Target Chain 32	UniProt (TrEMBL) Submitted Name of Target Chain 32	UniProt (TrEMBL) Entry Name of Target Chain 32	UniProt (TrEMBL) Primary ID of Target Chain 32	UniProt (TrEMBL) Secondary ID(s) of Target Chain 32	UniProt (TrEMBL) Alternative ID(s) of Target Chain 32	BindingDB Target Chain Sequence 33	PDB ID(s) of Target Chain 33	UniProt (SwissProt) Recommended Name of Target Chain 33	UniProt (SwissProt) Entry Name of Target Chain 33	UniProt (SwissProt) Primary ID of Target Chain 33	UniProt (SwissProt) Secondary ID(s) of Target Chain 33	UniProt (SwissProt) Alternative ID(s) of Target Chain 33	UniProt (TrEMBL) Submitted Name of Target Chain 33	UniProt (TrEMBL) Entry Name of Target Chain 33	UniProt (TrEMBL) Primary ID of Target Chain 33	UniProt (TrEMBL) Secondary ID(s) of Target Chain 33	UniProt (TrEMBL) Alternative ID(s) of Target Chain 33	BindingDB Target Chain Sequence 34	PDB ID(s) of Target Chain 34	UniProt (SwissProt) Recommended Name of Target Chain 34	UniProt (SwissProt) Entry Name of Target Chain 34	UniProt (SwissProt) Primary ID of Target Chain 34	UniProt (SwissProt) Secondary ID(s) of Target Chain 34	UniProt (SwissProt) Alternative ID(s) of Target Chain 34	UniProt (TrEMBL) Submitted Name of Target Chain 34	UniProt (TrEMBL) Entry Name of Target Chain 34	UniProt (TrEMBL) Primary ID of Target Chain 34	UniProt (TrEMBL) Secondary ID(s) of Target Chain 34	UniProt (TrEMBL) Alternative ID(s) of Target Chain 34	BindingDB Target Chain Sequence 35	PDB ID(s) of Target Chain 35	UniProt (SwissProt) Recommended Name of Target Chain 35	UniProt (SwissProt) Entry Name of Target Chain 35	UniProt (SwissProt) Primary ID of Target Chain 35	UniProt (SwissProt) Secondary ID(s) of Target Chain 35	UniProt (SwissProt) Alternative ID(s) of Target Chain 35	UniProt (TrEMBL) Submitted Name of Target Chain 35	UniProt (TrEMBL) Entry Name of Target Chain 35	UniProt (TrEMBL) Primary ID of Target Chain 35	UniProt (TrEMBL) Secondary ID(s) of Target Chain 35	UniProt (TrEMBL) Alternative ID(s) of Target Chain 35	BindingDB Target Chain Sequence 36	PDB ID(s) of Target Chain 36	UniProt (SwissProt) Recommended Name of Target Chain 36	UniProt (SwissProt) Entry Name of Target Chain 36	UniProt (SwissProt) Primary ID of Target Chain 36	UniProt (SwissProt) Secondary ID(s) of Target Chain 36	UniProt (SwissProt) Alternative ID(s) of Target Chain 36	UniProt (TrEMBL) Submitted Name of Target Chain 36	UniProt (TrEMBL) Entry Name of Target Chain 36	UniProt (TrEMBL) Primary ID of Target Chain 36	UniProt (TrEMBL) Secondary ID(s) of Target Chain 36	UniProt (TrEMBL) Alternative ID(s) of Target Chain 36	BindingDB Target Chain Sequence 37	PDB ID(s) of Target Chain 37	UniProt (SwissProt) Recommended Name of Target Chain 37	UniProt (SwissProt) Entry Name of Target Chain 37	UniProt (SwissProt) Primary ID of Target Chain 37	UniProt (SwissProt) Secondary ID(s) of Target Chain 37	UniProt (SwissProt) Alternative ID(s) of Target Chain 37	UniProt (TrEMBL) Submitted Name of Target Chain 37	UniProt (TrEMBL) Entry Name of Target Chain 37	UniProt (TrEMBL) Primary ID of Target Chain 37	UniProt (TrEMBL) Secondary ID(s) of Target Chain 37	UniProt (TrEMBL) Alternative ID(s) of Target Chain 37	BindingDB Target Chain Sequence 38	PDB ID(s) of Target Chain 38	UniProt (SwissProt) Recommended Name of Target Chain 38	UniProt (SwissProt) Entry Name of Target Chain 38	UniProt (SwissProt) Primary ID of Target Chain 38	UniProt (SwissProt) Secondary ID(s) of Target Chain 38	UniProt (SwissProt) Alternative ID(s) of Target Chain 38	UniProt (TrEMBL) Submitted Name of Target Chain 38	UniProt (TrEMBL) Entry Name of Target Chain 38	UniProt (TrEMBL) Primary ID of Target Chain 38	UniProt (TrEMBL) Secondary ID(s) of Target Chain 38	UniProt (TrEMBL) Alternative ID(s) of Target Chain 38	BindingDB Target Chain Sequence 39	PDB ID(s) of Target Chain 39	UniProt (SwissProt) Recommended Name of Target Chain 39	UniProt (SwissProt) Entry Name of Target Chain 39	UniProt (SwissProt) Primary ID of Target Chain 39	UniProt (SwissProt) Secondary ID(s) of Target Chain 39	UniProt (SwissProt) Alternative ID(s) of Target Chain 39	UniProt (TrEMBL) Submitted Name of Target Chain 39	UniProt (TrEMBL) Entry Name of Target Chain 39	UniProt (TrEMBL) Primary ID of Target Chain 39	UniProt (TrEMBL) Secondary ID(s) of Target Chain 39	UniProt (TrEMBL) Alternative ID(s) of Target Chain 39	BindingDB Target Chain Sequence 40	PDB ID(s) of Target Chain 40	UniProt (SwissProt) Recommended Name of Target Chain 40	UniProt (SwissProt) Entry Name of Target Chain 40	UniProt (SwissProt) Primary ID of Target Chain 40	UniProt (SwissProt) Secondary ID(s) of Target Chain 40	UniProt (SwissProt) Alternative ID(s) of Target Chain 40	UniProt (TrEMBL) Submitted Name of Target Chain 40	UniProt (TrEMBL) Entry Name of Target Chain 40	UniProt (TrEMBL) Primary ID of Target Chain 40	UniProt (TrEMBL) Secondary ID(s) of Target Chain 40	UniProt (TrEMBL) Alternative ID(s) of Target Chain 40	BindingDB Target Chain Sequence 41	PDB ID(s) of Target Chain 41	UniProt (SwissProt) Recommended Name of Target Chain 41	UniProt (SwissProt) Entry Name of Target Chain 41	UniProt (SwissProt) Primary ID of Target Chain 41	UniProt (SwissProt) Secondary ID(s) of Target Chain 41	UniProt (SwissProt) Alternative ID(s) of Target Chain 41	UniProt (TrEMBL) Submitted Name of Target Chain 41	UniProt (TrEMBL) Entry Name of Target Chain 41	UniProt (TrEMBL) Primary ID of Target Chain 41	UniProt (TrEMBL) Secondary ID(s) of Target Chain 41	UniProt (TrEMBL) Alternative ID(s) of Target Chain 41	BindingDB Target Chain Sequence 42	PDB ID(s) of Target Chain 42	UniProt (SwissProt) Recommended Name of Target Chain 42	UniProt (SwissProt) Entry Name of Target Chain 42	UniProt (SwissProt) Primary ID of Target Chain 42	UniProt (SwissProt) Secondary ID(s) of Target Chain 42	UniProt (SwissProt) Alternative ID(s) of Target Chain 42	UniProt (TrEMBL) Submitted Name of Target Chain 42	UniProt (TrEMBL) Entry Name of Target Chain 42	UniProt (TrEMBL) Primary ID of Target Chain 42	UniProt (TrEMBL) Secondary ID(s) of Target Chain 42	UniProt (TrEMBL) Alternative ID(s) of Target Chain 42	BindingDB Target Chain Sequence 43	PDB ID(s) of Target Chain 43	UniProt (SwissProt) Recommended Name of Target Chain 43	UniProt (SwissProt) Entry Name of Target Chain 43	UniProt (SwissProt) Primary ID of Target Chain 43	UniProt (SwissProt) Secondary ID(s) of Target Chain 43	UniProt (SwissProt) Alternative ID(s) of Target Chain 43	UniProt (TrEMBL) Submitted Name of Target Chain 43	UniProt (TrEMBL) Entry Name of Target Chain 43	UniProt (TrEMBL) Primary ID of Target Chain 43	UniProt (TrEMBL) Secondary ID(s) of Target Chain 43	UniProt (TrEMBL) Alternative ID(s) of Target Chain 43	BindingDB Target Chain Sequence 44	PDB ID(s) of Target Chain 44	UniProt (SwissProt) Recommended Name of Target Chain 44	UniProt (SwissProt) Entry Name of Target Chain 44	UniProt (SwissProt) Primary ID of Target Chain 44	UniProt (SwissProt) Secondary ID(s) of Target Chain 44	UniProt (SwissProt) Alternative ID(s) of Target Chain 44	UniProt (TrEMBL) Submitted Name of Target Chain 44	UniProt (TrEMBL) Entry Name of Target Chain 44	UniProt (TrEMBL) Primary ID of Target Chain 44	UniProt (TrEMBL) Secondary ID(s) of Target Chain 44	UniProt (TrEMBL) Alternative ID(s) of Target Chain 44	BindingDB Target Chain Sequence 45	PDB ID(s) of Target Chain 45	UniProt (SwissProt) Recommended Name of Target Chain 45	UniProt (SwissProt) Entry Name of Target Chain 45	UniProt (SwissProt) Primary ID of Target Chain 45	UniProt (SwissProt) Secondary ID(s) of Target Chain 45	UniProt (SwissProt) Alternative ID(s) of Target Chain 45	UniProt (TrEMBL) Submitted Name of Target Chain 45	UniProt (TrEMBL) Entry Name of Target Chain 45	UniProt (TrEMBL) Primary ID of Target Chain 45	UniProt (TrEMBL) Secondary ID(s) of Target Chain 45	UniProt (TrEMBL) Alternative ID(s) of Target Chain 45	BindingDB Target Chain Sequence 46	PDB ID(s) of Target Chain 46	UniProt (SwissProt) Recommended Name of Target Chain 46	UniProt (SwissProt) Entry Name of Target Chain 46	UniProt (SwissProt) Primary ID of Target Chain 46	UniProt (SwissProt) Secondary ID(s) of Target Chain 46	UniProt (SwissProt) Alternative ID(s) of Target Chain 46	UniProt (TrEMBL) Submitted Name of Target Chain 46	UniProt (TrEMBL) Entry Name of Target Chain 46	UniProt (TrEMBL) Primary ID of Target Chain 46	UniProt (TrEMBL) Secondary ID(s) of Target Chain 46	UniProt (TrEMBL) Alternative ID(s) of Target Chain 46	BindingDB Target Chain Sequence 47	PDB ID(s) of Target Chain 47	UniProt (SwissProt) Recommended Name of Target Chain 47	UniProt (SwissProt) Entry Name of Target Chain 47	UniProt (SwissProt) Primary ID of Target Chain 47	UniProt (SwissProt) Secondary ID(s) of Target Chain 47	UniProt (SwissProt) Alternative ID(s) of Target Chain 47	UniProt (TrEMBL) Submitted Name of Target Chain 47	UniProt (TrEMBL) Entry Name of Target Chain 47	UniProt (TrEMBL) Primary ID of Target Chain 47	UniProt (TrEMBL) Secondary ID(s) of Target Chain 47	UniProt (TrEMBL) Alternative ID(s) of Target Chain 47	BindingDB Target Chain Sequence 48	PDB ID(s) of Target Chain 48	UniProt (SwissProt) Recommended Name of Target Chain 48	UniProt (SwissProt) Entry Name of Target Chain 48	UniProt (SwissProt) Primary ID of Target Chain 48	UniProt (SwissProt) Secondary ID(s) of Target Chain 48	UniProt (SwissProt) Alternative ID(s) of Target Chain 48	UniProt (TrEMBL) Submitted Name of Target Chain 48	UniProt (TrEMBL) Entry Name of Target Chain 48	UniProt (TrEMBL) Primary ID of Target Chain 48	UniProt (TrEMBL) Secondary ID(s) of Target Chain 48	UniProt (TrEMBL) Alternative ID(s) of Target Chain 48	BindingDB Target Chain Sequence 49	PDB ID(s) of Target Chain 49	UniProt (SwissProt) Recommended Name of Target Chain 49	UniProt (SwissProt) Entry Name of Target Chain 49	UniProt (SwissProt) Primary ID of Target Chain 49	UniProt (SwissProt) Secondary ID(s) of Target Chain 49	UniProt (SwissProt) Alternative ID(s) of Target Chain 49	UniProt (TrEMBL) Submitted Name of Target Chain 49	UniProt (TrEMBL) Entry Name of Target Chain 49	UniProt (TrEMBL) Primary ID of Target Chain 49	UniProt (TrEMBL) Secondary ID(s) of Target Chain 49	UniProt (TrEMBL) Alternative ID(s) of Target Chain 49	BindingDB Target Chain Sequence 50	PDB ID(s) of Target Chain 50	UniProt (SwissProt) Recommended Name of Target Chain 50	UniProt (SwissProt) Entry Name of Target Chain 50	UniProt (SwissProt) Primary ID of Target Chain 50	UniProt (SwissProt) Secondary ID(s) of Target Chain 50	UniProt (SwissProt) Alternative ID(s) of Target Chain 50	UniProt (TrEMBL) Submitted Name of Target Chain 50	UniProt (TrEMBL) Entry Name of Target Chain 50	UniProt (TrEMBL) Primary ID of Target Chain 50	UniProt (TrEMBL) Secondary ID(s) of Target Chain 50	UniProt (TrEMBL) Alternative ID(s) of Target Chain 50
192881	CC(C)COc1ccc(CNC(=O)N(Cc2ccc(Cl)cn2)C2CCN(C)CC2)cc1	InChI=1S/C24H33ClN4O2/c1-18(2)17-31-23-8-4-19(5-9-23)14-27-24(30)29(22-10-12-28(3)13-11-22)16-21-7-6-20(25)15-26-21/h4-9,15,18,22H,10-14,16-17H2,1-3H3,(H,27,30)	YEDRUSULEMDABE-UHFFFAOYSA-N	368957	US12527775, Compound I-009	5-hydroxytryptamine receptor 2A	Homo sapiens	 0.291								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368957	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368957&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90115293	402365756							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192882	CC(C)COc1ccc(CNC(=O)N(Cc2ccn(C)n2)C2CCN(C)CC2)cc1	InChI=1S/C23H35N5O2/c1-18(2)17-30-22-7-5-19(6-8-22)15-24-23(29)28(16-20-9-14-27(4)25-20)21-10-12-26(3)13-11-21/h5-9,14,18,21H,10-13,15-17H2,1-4H3,(H,24,29)	DYVUYEIPCXXJPJ-UHFFFAOYSA-N	368958	US12527775, Compound I-021	5-hydroxytryptamine receptor 2A	Homo sapiens	 0.858								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368958	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368958&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90115129	402365757							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192883	CC(C)COc1ccc(CNC(=O)N(Cc2cc3ccccc3cn2)C2CCN(C)CC2)cc1	InChI=1S/C28H36N4O2/c1-21(2)20-34-27-10-8-22(9-11-27)17-30-28(33)32(26-12-14-31(3)15-13-26)19-25-16-23-6-4-5-7-24(23)18-29-25/h4-11,16,18,21,26H,12-15,17,19-20H2,1-3H3,(H,30,33)	DMEZBDVKBCXCAW-UHFFFAOYSA-N	368959	US12527775, Compound I-037	5-hydroxytryptamine receptor 2A	Homo sapiens	 0.654								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368959	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368959&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90114833	402365758							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192884	CC(C)COc1ccc(COC(=O)N(Cc2ccc(F)cn2)C2CCN(C)CC2)cc1	InChI=1S/C24H32FN3O3/c1-18(2)16-30-23-8-4-19(5-9-23)17-31-24(29)28(22-10-12-27(3)13-11-22)15-21-7-6-20(25)14-26-21/h4-9,14,18,22H,10-13,15-17H2,1-3H3	JOHIZHSVLNZEFM-UHFFFAOYSA-N	368960	US12527775, Compound I-042	5-hydroxytryptamine receptor 2A	Homo sapiens	 1.15								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368960	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368960&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90114882	402365759							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192885	COc1ccc(CNC(=O)N(Cc2ccc(F)cn2)C2CCN(C)CC2)cc1	InChI=1S/C21H27FN4O2/c1-25-11-9-19(10-12-25)26(15-18-6-5-17(22)14-23-18)21(27)24-13-16-3-7-20(28-2)8-4-16/h3-8,14,19H,9-13,15H2,1-2H3,(H,24,27)	PUALGYQQGJBFFN-UHFFFAOYSA-N	368961	US12527775, Compound I-043	5-hydroxytryptamine receptor 2A	Homo sapiens	 2.52								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368961	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368961&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90114593	402365760							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192886	CC(C)COc1ccc(CC(=O)N(Cc2ccc(F)cn2)C2CCN(C)CC2)cc1	InChI=1S/C24H32FN3O2/c1-18(2)17-30-23-8-4-19(5-9-23)14-24(29)28(22-10-12-27(3)13-11-22)16-21-7-6-20(25)15-26-21/h4-9,15,18,22H,10-14,16-17H2,1-3H3	QVKDJGZGOMKBSU-UHFFFAOYSA-N	368962	US12527775, Compound I-068	5-hydroxytryptamine receptor 2A	Homo sapiens	 6.52								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368962	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368962&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90114293	402365761							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192887	CC(C)COc1ccc(CNC(=O)N(Cc2ccc(F)c3ccoc23)C2CCN(C)CC2)cc1	InChI=1S/C27H34FN3O3/c1-19(2)18-34-23-7-4-20(5-8-23)16-29-27(32)31(22-10-13-30(3)14-11-22)17-21-6-9-25(28)24-12-15-33-26(21)24/h4-9,12,15,19,22H,10-11,13-14,16-18H2,1-3H3,(H,29,32)	VORIIPRUWIHSRU-UHFFFAOYSA-N	368963	US12527775, Compound I-071	5-hydroxytryptamine receptor 2A	Homo sapiens	 13.3								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368963	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368963&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90114821	402365762							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192888	CC(C)COc1ccc(CNC(=O)N(Cc2cc3c(cn2)OCCO3)C2CCN(C)CC2)cc1	InChI=1S/C26H36N4O4/c1-19(2)18-34-23-6-4-20(5-7-23)15-28-26(31)30(22-8-10-29(3)11-9-22)17-21-14-24-25(16-27-21)33-13-12-32-24/h4-7,14,16,19,22H,8-13,15,17-18H2,1-3H3,(H,28,31)	ZKMKNANNWRLODJ-UHFFFAOYSA-N	368964	US12527775, Compound I-072	5-hydroxytryptamine receptor 2A	Homo sapiens	 219								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368964	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368964&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90114960	402365763							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192889	CN1CCC(N(Cc2ccc(F)cn2)C(=O)NCc2cccc(O)c2)CC1	InChI=1S/C20H25FN4O2/c1-24-9-7-18(8-10-24)25(14-17-6-5-16(21)13-22-17)20(27)23-12-15-3-2-4-19(26)11-15/h2-6,11,13,18,26H,7-10,12,14H2,1H3,(H,23,27)	WBOIGIZGFANRAP-UHFFFAOYSA-N	368965	US12527775, Compound I-075	5-hydroxytryptamine receptor 2A	Homo sapiens	 130								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368965	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368965&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90115033	402365764							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192890	CN1CCC(N(Cc2ccc(F)cn2)C(=O)NCc2ccccc2O)CC1	InChI=1S/C20H25FN4O2/c1-24-10-8-18(9-11-24)25(14-17-7-6-16(21)13-22-17)20(27)23-12-15-4-2-3-5-19(15)26/h2-7,13,18,26H,8-12,14H2,1H3,(H,23,27)	FCMOKMRAVXNDRP-UHFFFAOYSA-N	368966	US12527775, Compound I-076	5-hydroxytryptamine receptor 2A	Homo sapiens	 62.0								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368966	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368966&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90115325	402365765							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192891	CN1CCC(N(Cc2ccc(F)cn2)C(=O)NCc2ccc(Br)cc2)CC1	InChI=1S/C20H24BrFN4O/c1-25-10-8-19(9-11-25)26(14-18-7-6-17(22)13-23-18)20(27)24-12-15-2-4-16(21)5-3-15/h2-7,13,19H,8-12,14H2,1H3,(H,24,27)	ADIMPFIRIIXWIL-UHFFFAOYSA-N	368967	US12527775, Compound I-082	5-hydroxytryptamine receptor 2A	Homo sapiens	 3.74								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368967	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368967&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90114782	402365766							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192892	CN1CCC(N(Cc2ccc(F)cn2)C(=O)NCc2ccc(Cl)cc2)CC1	InChI=1S/C20H24ClFN4O/c1-25-10-8-19(9-11-25)26(14-18-7-6-17(22)13-23-18)20(27)24-12-15-2-4-16(21)5-3-15/h2-7,13,19H,8-12,14H2,1H3,(H,24,27)	DUBASJUZOVOHOD-UHFFFAOYSA-N	368968	US12527775, Compound I-084	5-hydroxytryptamine receptor 2A	Homo sapiens	 5.61								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368968	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368968&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90114634	402365767							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192893	CC(C)COc1ccc(CNC(=O)N(Cc2ccc(F)cn2)[C@@H]2CCN(C)C[C@@H]2F)cc1	InChI=1S/C24H32F2N4O2/c1-17(2)16-32-21-8-4-18(5-9-21)12-28-24(31)30(14-20-7-6-19(25)13-27-20)23-10-11-29(3)15-22(23)26/h4-9,13,17,22-23H,10-12,14-16H2,1-3H3,(H,28,31)	RELRUDTWGGXBJF-UHFFFAOYSA-N	368969	US12527775, Compound I-085	5-hydroxytryptamine receptor 2A	Homo sapiens	 23.8								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368969	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368969&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90115474	402365768							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192894	CC(C)COc1ccc(CNC(=O)N(Cc2ccc(F)cn2)[C@H]2CCN(C)C[C@@H]2O)cc1	InChI=1S/C24H33FN4O3/c1-17(2)16-32-21-8-4-18(5-9-21)12-27-24(31)29(14-20-7-6-19(25)13-26-20)22-10-11-28(3)15-23(22)30/h4-9,13,17,22-23,30H,10-12,14-16H2,1-3H3,(H,27,31)	OTQNKXUNJMNGOX-UHFFFAOYSA-N	368970	US12527775, Compound I-088	5-hydroxytryptamine receptor 2A	Homo sapiens	 25.7								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368970	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368970&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90114809	402365769							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192895	CCCOc1ccc(CNC(=O)N(Cc2ccn(C)n2)[C@H]2CCN(C)CC23CC3)cc1	InChI=1S/C24H35N5O2/c1-4-15-31-21-7-5-19(6-8-21)16-25-23(30)29(17-20-9-14-28(3)26-20)22-10-13-27(2)18-24(22)11-12-24/h5-9,14,22H,4,10-13,15-18H2,1-3H3,(H,25,30)	HOVLTWZHAUDSGN-UHFFFAOYSA-N	50645461	CHEMBL5592950::US12527775, Compound I-102	5-hydroxytryptamine receptor 2A	Homo sapiens	 0.919								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50645461	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50645461&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			169811671	519660863							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192896	CCc1ccc(CNC(=O)N(Cc2ccc(F)cn2)C2CCN(C)CC2)cc1	InChI=1S/C22H29FN4O/c1-3-17-4-6-18(7-5-17)14-25-22(28)27(21-10-12-26(2)13-11-21)16-20-9-8-19(23)15-24-20/h4-9,15,21H,3,10-14,16H2,1-2H3,(H,25,28)	QWNGGMAFPJOHPR-UHFFFAOYSA-N	368973	US12527775, Compound I-116	5-hydroxytryptamine receptor 2A	Homo sapiens	 1.45								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368973	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368973&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90114638	402365772							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192897	CC(C)COc1ccc(CNC(=O)N(Cc2ccn(C)c2)[C@H]2CCNC[C@H]2F)cc1	InChI=1S/C23H33FN4O2/c1-17(2)16-30-20-6-4-18(5-7-20)12-26-23(29)28(15-19-9-11-27(3)14-19)22-8-10-25-13-21(22)24/h4-7,9,11,14,17,21-22,25H,8,10,12-13,15-16H2,1-3H3,(H,26,29)	WXBLNXYIJLJMGY-UHFFFAOYSA-N	368974	US12527775, Compound I-124	5-hydroxytryptamine receptor 2A	Homo sapiens	 0.690								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368974	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368974&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90115247	402365773							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192898	CCCOc1ccc(CNC(=O)N(Cc2cc(C)n(C)n2)[C@H]2CCN(C)CC23CC3)cc1	InChI=1S/C25H37N5O2/c1-5-14-32-22-8-6-20(7-9-22)16-26-24(31)30(17-21-15-19(2)29(4)27-21)23-10-13-28(3)18-25(23)11-12-25/h6-9,15,23H,5,10-14,16-18H2,1-4H3,(H,26,31)	BOKIASHIRMLMKK-UHFFFAOYSA-N	368975	US12527775, Compound I-126	5-hydroxytryptamine receptor 2A	Homo sapiens	 1.92								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368975	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368975&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90114891	402365774							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192899	CC(C)CNc1ccc(CNC(=O)N(Cc2ccc(F)cn2)[C@H]2CCNC[C@H]2F)cc1	InChI=1S/C23H31F2N5O/c1-16(2)11-27-19-6-3-17(4-7-19)12-29-23(31)30(22-9-10-26-14-21(22)25)15-20-8-5-18(24)13-28-20/h3-8,13,16,21-22,26-27H,9-12,14-15H2,1-2H3,(H,29,31)	JOONQQPCPNINAA-UHFFFAOYSA-N	368976	US12527775, Compound I-129	5-hydroxytryptamine receptor 2A	Homo sapiens	 0.850								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368976	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368976&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90113968	402365775							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192900	COCc1ccc(CNC(=O)N(Cc2ccc(C)cn2)C2CCN(C)CC2)cc1	InChI=1S/C23H32N4O2/c1-18-4-9-21(24-14-18)16-27(22-10-12-26(2)13-11-22)23(28)25-15-19-5-7-20(8-6-19)17-29-3/h4-9,14,22H,10-13,15-17H2,1-3H3,(H,25,28)	FORWHHUOSDGSMH-UHFFFAOYSA-N	368977	US12527775, Compound I-130	5-hydroxytryptamine receptor 2A	Homo sapiens	 15.3								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368977	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368977&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90115078	402365776							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192901	CCCOc1ccc(CNC(=O)N(Cc2ccn(C)c2)[C@H]2CCNC[C@H]2F)cc1	InChI=1S/C22H31FN4O2/c1-3-12-29-19-6-4-17(5-7-19)13-25-22(28)27(16-18-9-11-26(2)15-18)21-8-10-24-14-20(21)23/h4-7,9,11,15,20-21,24H,3,8,10,12-14,16H2,1-2H3,(H,25,28)	KGNCORAPCMJZMR-UHFFFAOYSA-N	368978	US12527775, Compound I-134	5-hydroxytryptamine receptor 2A	Homo sapiens	 0.475								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368978	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368978&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90115344	402365777							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192902	CC(C)COc1ccc(CNC(=O)N(Cc2ccc(F)cn2)C2CCN(C)C3(CC3)C2)cc1	InChI=1S/C26H35FN4O2/c1-19(2)18-33-24-8-4-20(5-9-24)15-29-25(32)31(17-22-7-6-21(27)16-28-22)23-10-13-30(3)26(14-23)11-12-26/h4-9,16,19,23H,10-15,17-18H2,1-3H3,(H,29,32)	MGTJJEWROCDVOA-UHFFFAOYSA-N	368979	US12527775, Compound I-136	5-hydroxytryptamine receptor 2A	Homo sapiens	 8.02								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368979	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368979&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90114674	402365778							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192903	CCCOc1ccc(CNC(=O)N(Cc2cc(C)n(C)n2)[C@H]2CCN(C)C[C@H]2F)cc1	InChI=1S/C23H34FN5O2/c1-5-12-31-20-8-6-18(7-9-20)14-25-23(30)29(15-19-13-17(2)28(4)26-19)22-10-11-27(3)16-21(22)24/h6-9,13,21-22H,5,10-12,14-16H2,1-4H3,(H,25,30)	MBTSTFUSFZSMQV-UHFFFAOYSA-N	368980	US12527775, Compound I-139	5-hydroxytryptamine receptor 2A	Homo sapiens	 2.93								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368980	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368980&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90114562	402365779							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192904	CC(C)COc1ccc(CNC(=O)N(Cc2cc(CF)n(C)n2)[C@H]2CCN(C)C[C@H]2F)cc1	InChI=1S/C24H35F2N5O2/c1-17(2)16-33-21-7-5-18(6-8-21)13-27-24(32)31(23-9-10-29(3)15-22(23)26)14-19-11-20(12-25)30(4)28-19/h5-8,11,17,22-23H,9-10,12-16H2,1-4H3,(H,27,32)	UEOITUGSFHEHMM-UHFFFAOYSA-N	368981	US12527775, Compound I-146	5-hydroxytryptamine receptor 2A	Homo sapiens	 1.94								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368981	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368981&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90114837	402365780							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192905	CC(C)CN(C)c1ccc(CNC(=O)N(Cc2ccc(F)cn2)[C@H]2CCN(C)C[C@H]2F)cc1	InChI=1S/C25H35F2N5O/c1-18(2)15-31(4)22-9-5-19(6-10-22)13-29-25(33)32(16-21-8-7-20(26)14-28-21)24-11-12-30(3)17-23(24)27/h5-10,14,18,23-24H,11-13,15-17H2,1-4H3,(H,29,33)	OZWUSGMYHJFGFC-UHFFFAOYSA-N	368982	US12527775, Compound I-147	5-hydroxytryptamine receptor 2A	Homo sapiens	 0.758								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368982	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368982&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90134911	402365781							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192906	CC(C)COc1ccc(CNC(=O)N(Cc2ccccn2)C2CCN(C)CC2)cc1	InChI=1S/C24H34N4O2/c1-19(2)18-30-23-9-7-20(8-10-23)16-26-24(29)28(17-21-6-4-5-13-25-21)22-11-14-27(3)15-12-22/h4-10,13,19,22H,11-12,14-18H2,1-3H3,(H,26,29)	UXTPWMGDBKRHQC-UHFFFAOYSA-N	368983	US12527775, Compound I-001	5-hydroxytryptamine receptor 2A	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368983	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368983&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90114499	402365782							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192907	CC(C)COc1ccc(CNC(=O)N(Cc2cccnc2)C2CCN(C)CC2)cc1	InChI=1S/C24H34N4O2/c1-19(2)18-30-23-8-6-20(7-9-23)16-26-24(29)28(17-21-5-4-12-25-15-21)22-10-13-27(3)14-11-22/h4-9,12,15,19,22H,10-11,13-14,16-18H2,1-3H3,(H,26,29)	VRNUNIGKMGDJJK-UHFFFAOYSA-N	368984	US12527775, Compound I-002	5-hydroxytryptamine receptor 2A	Homo sapiens	>100								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368984	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368984&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90114619	402365783							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192908	CC(C)COc1ccc(CNC(=O)N(Cc2ccncc2)C2CCN(C)CC2)cc1	InChI=1S/C24H34N4O2/c1-19(2)18-30-23-6-4-20(5-7-23)16-26-24(29)28(17-21-8-12-25-13-9-21)22-10-14-27(3)15-11-22/h4-9,12-13,19,22H,10-11,14-18H2,1-3H3,(H,26,29)	LVRLTRCYPPEDBZ-UHFFFAOYSA-N	368985	US12527775, Compound I-003	5-hydroxytryptamine receptor 2A	Homo sapiens	>100								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368985	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368985&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90115175	402365784							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192909	CC(C)COc1ccc(CNC(=O)N(Cc2ncccn2)C2CCN(C)CC2)cc1	InChI=1S/C23H33N5O2/c1-18(2)17-30-21-7-5-19(6-8-21)15-26-23(29)28(16-22-24-11-4-12-25-22)20-9-13-27(3)14-10-20/h4-8,11-12,18,20H,9-10,13-17H2,1-3H3,(H,26,29)	UTLOXSBDULDVCZ-UHFFFAOYSA-N	368986	US12527775, Compound I-004	5-hydroxytryptamine receptor 2A	Homo sapiens	>100								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368986	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368986&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90114605	402365785							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192910	CC(C)COc1ccc(CNC(=O)N(Cc2cccnn2)C2CCN(C)CC2)cc1	InChI=1S/C23H33N5O2/c1-18(2)17-30-22-8-6-19(7-9-22)15-24-23(29)28(16-20-5-4-12-25-26-20)21-10-13-27(3)14-11-21/h4-9,12,18,21H,10-11,13-17H2,1-3H3,(H,24,29)	BSFQDIYLWRZEAM-UHFFFAOYSA-N	368987	US12527775, Compound I-005	5-hydroxytryptamine receptor 2A	Homo sapiens	>100								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368987	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368987&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90114842	402365786							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192911	CC(C)COc1ccc(CNC(=O)N(Cc2cnccn2)C2CCN(C)CC2)cc1	InChI=1S/C23H33N5O2/c1-18(2)17-30-22-6-4-19(5-7-22)14-26-23(29)28(16-20-15-24-10-11-25-20)21-8-12-27(3)13-9-21/h4-7,10-11,15,18,21H,8-9,12-14,16-17H2,1-3H3,(H,26,29)	WXMBSNFSLZTCEU-UHFFFAOYSA-N	368988	US12527775, Compound I-006	5-hydroxytryptamine receptor 2A	Homo sapiens	>100								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368988	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368988&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90114288	402365787							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192912	CC(C)COc1ccc(CNC(=O)N(Cc2cncnc2)C2CCN(C)CC2)cc1	InChI=1S/C23H33N5O2/c1-18(2)16-30-22-6-4-19(5-7-22)14-26-23(29)28(15-20-12-24-17-25-13-20)21-8-10-27(3)11-9-21/h4-7,12-13,17-18,21H,8-11,14-16H2,1-3H3,(H,26,29)	KZAAESQVSREAQR-UHFFFAOYSA-N	368989	US12527775, Compound I-007	5-hydroxytryptamine receptor 2A	Homo sapiens	>100								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368989	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368989&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90114402	402365788							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192913	CC(C)COc1ccc(CNC(=O)N(Cc2ccc(F)cn2)C2CCN(C)CC2)cc1	InChI=1S/C24H33FN4O2/c1-18(2)17-31-23-8-4-19(5-9-23)14-27-24(30)29(22-10-12-28(3)13-11-22)16-21-7-6-20(25)15-26-21/h4-9,15,18,22H,10-14,16-17H2,1-3H3,(H,27,30)	MLLAVJGUUBZDGD-UHFFFAOYSA-N	50596718	CHEMBL5184703::US20230348421, Compound 1::US12527775, Compound I-008	5-hydroxytryptamine receptor 2A	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50596718	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50596718&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			168283780	482607570							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192914	COc1ccc(CN(C(=O)NCc2ccc(OCC(C)C)cc2)C2CCN(C)CC2)nc1	InChI=1S/C25H36N4O3/c1-19(2)18-32-23-8-5-20(6-9-23)15-27-25(30)29(22-11-13-28(3)14-12-22)17-21-7-10-24(31-4)16-26-21/h5-10,16,19,22H,11-15,17-18H2,1-4H3,(H,27,30)	BKTVUNBWQXVJSW-UHFFFAOYSA-N	368991	US12527775, Compound I-010	5-hydroxytryptamine receptor 2A	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368991	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368991&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90114393	402365790							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192915	N#Cc1ccc(CN(C(=O)NCc2ccc(OCC(C)C)cc2)C2CCN(C)CC2)nc1	InChI=1S/C25H33N5O2/c1-19(2)18-32-24-8-5-20(6-9-24)15-28-25(31)30(23-10-12-29(3)13-11-23)17-22-7-4-21(14-26)16-27-22/h4-9,16,19,23H,10-13,15,17-18H2,1-3H3,(H,28,31)	XBAOKRXXQFILIC-UHFFFAOYSA-N	368992	US12527775, Compound I-011	5-hydroxytryptamine receptor 2A	Homo sapiens	 55								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368992	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368992&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90114814	402365791							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192916	CC(C)COc1ccc(CNC(=O)N(Cc2ccc(C(F)(F)F)cn2)C2CCN(C)CC2)cc1	InChI=1S/C25H33F3N4O2/c1-18(2)17-34-23-8-4-19(5-9-23)14-30-24(33)32(22-10-12-31(3)13-11-22)16-21-7-6-20(15-29-21)25(26,27)28/h4-9,15,18,22H,10-14,16-17H2,1-3H3,(H,30,33)	HVWRVSOCJOCWJU-UHFFFAOYSA-N	368993	US12527775, Compound I-012	5-hydroxytryptamine receptor 2A	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368993	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368993&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			86718040	402365792							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192917	Cc1ccc(CN(C(=O)NCc2ccc(OCC(C)C)cc2)C2CCN(C)CC2)nc1	InChI=1S/C25H36N4O2/c1-19(2)18-31-24-9-6-21(7-10-24)16-27-25(30)29(23-11-13-28(4)14-12-23)17-22-8-5-20(3)15-26-22/h5-10,15,19,23H,11-14,16-18H2,1-4H3,(H,27,30)	GJGJPQXDSCFRCH-UHFFFAOYSA-N	368995	US12527775, Compound I-013	5-hydroxytryptamine receptor 2A	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368995	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368995&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90115179	402365793							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192918	CC(C)COc1ccc(CNC(=O)N(Cc2ncc(F)cc2F)C2CCN(C)CC2)cc1	InChI=1S/C24H32F2N4O2/c1-17(2)16-32-21-6-4-18(5-7-21)13-28-24(31)30(20-8-10-29(3)11-9-20)15-23-22(26)12-19(25)14-27-23/h4-7,12,14,17,20H,8-11,13,15-16H2,1-3H3,(H,28,31)	CXDAWYJEMGTVJX-UHFFFAOYSA-N	50596720	CHEMBL5200635::US12527775, Compound I-014	5-hydroxytryptamine receptor 2A	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50596720	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50596720&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			168292138	482607572							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192919	CC(C)COc1ccc(CNC(=O)N(Cc2ncc(F)cc2Cl)C2CCN(C)CC2)cc1	InChI=1S/C24H32ClFN4O2/c1-17(2)16-32-21-6-4-18(5-7-21)13-28-24(31)30(20-8-10-29(3)11-9-20)15-23-22(25)12-19(26)14-27-23/h4-7,12,14,17,20H,8-11,13,15-16H2,1-3H3,(H,28,31)	BKQXAIWOMSDZGY-UHFFFAOYSA-N	368997	US12527775, Compound I-015	5-hydroxytryptamine receptor 2A	Homo sapiens	>100								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368997	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368997&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90114489	402365795							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192920	CC(C)COc1ccc(CNC(=O)N(Cc2ncccc2F)C2CCN(C)CC2)cc1	InChI=1S/C24H33FN4O2/c1-18(2)17-31-21-8-6-19(7-9-21)15-27-24(30)29(20-10-13-28(3)14-11-20)16-23-22(25)5-4-12-26-23/h4-9,12,18,20H,10-11,13-17H2,1-3H3,(H,27,30)	ZAMMVJDZUPUELZ-UHFFFAOYSA-N	368998	US12527775, Compound I-016	5-hydroxytryptamine receptor 2A	Homo sapiens	 55								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368998	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368998&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90114309	402365796							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192921	CC(C)COc1ccc(CNC(=O)N(Cc2cc(F)ccn2)C2CCN(C)CC2)cc1	InChI=1S/C24H33FN4O2/c1-18(2)17-31-23-6-4-19(5-7-23)15-27-24(30)29(22-9-12-28(3)13-10-22)16-21-14-20(25)8-11-26-21/h4-8,11,14,18,22H,9-10,12-13,15-17H2,1-3H3,(H,27,30)	YHABPOZFDXRKMW-UHFFFAOYSA-N	368999	US12527775, Compound I-017	5-hydroxytryptamine receptor 2A	Homo sapiens	 55								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368999	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368999&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90114768	402365797							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192922	CC(C)COc1ccc(CNC(=O)N(Cc2cccc(F)n2)C2CCN(C)CC2)cc1	InChI=1S/C24H33FN4O2/c1-18(2)17-31-22-9-7-19(8-10-22)15-26-24(30)29(21-11-13-28(3)14-12-21)16-20-5-4-6-23(25)27-20/h4-10,18,21H,11-17H2,1-3H3,(H,26,30)	ZSMHROITERWGGD-UHFFFAOYSA-N	369000	US12527775, Compound I-018	5-hydroxytryptamine receptor 2A	Homo sapiens	 55								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369000	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369000&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90114017	402365798							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192923	CC(C)COc1ccc(CNC(=O)N(Cc2ccc(F)nc2)C2CCN(C)CC2)cc1	InChI=1S/C24H33FN4O2/c1-18(2)17-31-22-7-4-19(5-8-22)14-27-24(30)29(21-10-12-28(3)13-11-21)16-20-6-9-23(25)26-15-20/h4-9,15,18,21H,10-14,16-17H2,1-3H3,(H,27,30)	NLNJPUVDBXPERZ-UHFFFAOYSA-N	50596750	CHEMBL5179185::US12527775, Compound I-019	5-hydroxytryptamine receptor 2A	Homo sapiens	>100								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50596750	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50596750&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			168274667	482607602							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192924	CC(C)COc1ccc(CNC(=O)N(Cc2ncc(F)cn2)C2CCN(C)CC2)cc1	InChI=1S/C23H32FN5O2/c1-17(2)16-31-21-6-4-18(5-7-21)12-27-23(30)29(20-8-10-28(3)11-9-20)15-22-25-13-19(24)14-26-22/h4-7,13-14,17,20H,8-12,15-16H2,1-3H3,(H,27,30)	KBFQXTVCSCMAII-UHFFFAOYSA-N	631390	US20230348421, Compound 13::US12527775, Compound I-020	5-hydroxytryptamine receptor 2A	Homo sapiens	 55								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=631390	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=631390&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			169490282	485658868							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192925	CC(C)COc1ccc(CNC(=O)N(Cc2cnn(C)c2)C2CCN(C)CC2)cc1	InChI=1S/C23H35N5O2/c1-18(2)17-30-22-7-5-19(6-8-22)13-24-23(29)28(16-20-14-25-27(4)15-20)21-9-11-26(3)12-10-21/h5-8,14-15,18,21H,9-13,16-17H2,1-4H3,(H,24,29)	WQZCXKPBFILXFJ-UHFFFAOYSA-N	369003	US12527775, Compound I-022	5-hydroxytryptamine receptor 2A	Homo sapiens	>100								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369003	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369003&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			89993976	402365801							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192926	CC(C)COc1ccc(CNC(=O)N(Cc2ccnn2C)C2CCN(C)CC2)cc1	InChI=1S/C23H35N5O2/c1-18(2)17-30-22-7-5-19(6-8-22)15-24-23(29)28(16-21-9-12-25-27(21)4)20-10-13-26(3)14-11-20/h5-9,12,18,20H,10-11,13-17H2,1-4H3,(H,24,29)	LXTUMJFQUUGWQL-UHFFFAOYSA-N	369004	US12527775, Compound I-023	5-hydroxytryptamine receptor 2A	Homo sapiens	>100								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369004	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369004&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90115409	402365802							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192927	CC(C)COc1ccc(CNC(=O)N(Cc2nccn2C)C2CCN(C)CC2)cc1	InChI=1S/C23H35N5O2/c1-18(2)17-30-21-7-5-19(6-8-21)15-25-23(29)28(16-22-24-11-14-27(22)4)20-9-12-26(3)13-10-20/h5-8,11,14,18,20H,9-10,12-13,15-17H2,1-4H3,(H,25,29)	BUHFKUPHTQNPNM-UHFFFAOYSA-N	369005	US12527775, Compound I-024	5-hydroxytryptamine receptor 2A	Homo sapiens	>100								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369005	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369005&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90114955	402365803							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192928	CC(C)COc1ccc(CNC(=O)N(Cc2cn(C)cn2)C2CCN(C)CC2)cc1	InChI=1S/C23H35N5O2/c1-18(2)16-30-22-7-5-19(6-8-22)13-24-23(29)28(15-20-14-27(4)17-25-20)21-9-11-26(3)12-10-21/h5-8,14,17-18,21H,9-13,15-16H2,1-4H3,(H,24,29)	UIDHOJOSTPSITG-UHFFFAOYSA-N	369006	US12527775, Compound I-025	5-hydroxytryptamine receptor 2A	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369006	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369006&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90114720	402365804							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192929	CC(C)COc1ccc(CNC(=O)N(Cc2cc[nH]n2)C2CCN(C)CC2)cc1	InChI=1S/C22H33N5O2/c1-17(2)16-29-21-6-4-18(5-7-21)14-23-22(28)27(15-19-8-11-24-25-19)20-9-12-26(3)13-10-20/h4-8,11,17,20H,9-10,12-16H2,1-3H3,(H,23,28)(H,24,25)	HRRFYAWWLLIVHO-UHFFFAOYSA-N	369007	US12527775, Compound I-026	5-hydroxytryptamine receptor 2A	Homo sapiens	 55								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369007	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369007&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90115339	402365805							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192930	CC(C)COc1ccc(CNC(=O)N(Cc2ccn(C)c2)C2CCN(C)CC2)cc1	InChI=1S/C24H36N4O2/c1-19(2)18-30-23-7-5-20(6-8-23)15-25-24(29)28(17-21-9-12-27(4)16-21)22-10-13-26(3)14-11-22/h5-9,12,16,19,22H,10-11,13-15,17-18H2,1-4H3,(H,25,29)	RTKOEICOSPJBQY-UHFFFAOYSA-N	369008	US12527775, Compound I-027	5-hydroxytryptamine receptor 2A	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369008	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369008&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90114701	402365806							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192931	CC(C)COc1ccc(CNC(=O)N(Cc2cccn2C)C2CCN(C)CC2)cc1	InChI=1S/C24H36N4O2/c1-19(2)18-30-23-9-7-20(8-10-23)16-25-24(29)28(17-22-6-5-13-27(22)4)21-11-14-26(3)15-12-21/h5-10,13,19,21H,11-12,14-18H2,1-4H3,(H,25,29)	JXBZJUKLAIEHHN-UHFFFAOYSA-N	369009	US12527775, Compound I-028	5-hydroxytryptamine receptor 2A	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369009	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369009&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90114237	402365807							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192932	CC(C)COc1ccc(CNC(=O)N(Cc2cccs2)C2CCN(C)CC2)cc1	InChI=1S/C23H33N3O2S/c1-18(2)17-28-21-8-6-19(7-9-21)15-24-23(27)26(16-22-5-4-14-29-22)20-10-12-25(3)13-11-20/h4-9,14,18,20H,10-13,15-17H2,1-3H3,(H,24,27)	BHSGHONNOZWKFB-UHFFFAOYSA-N	369010	US12527775, Compound I-029	5-hydroxytryptamine receptor 2A	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369010	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369010&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90115353	402365808							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192933	Cc1ccc(CN(C(=O)NCc2ccc(OCC(C)C)cc2)C2CCN(C)CC2)s1	InChI=1S/C24H35N3O2S/c1-18(2)17-29-22-8-6-20(7-9-22)15-25-24(28)27(16-23-10-5-19(3)30-23)21-11-13-26(4)14-12-21/h5-10,18,21H,11-17H2,1-4H3,(H,25,28)	QEIHFEYWIJXBRN-UHFFFAOYSA-N	369011	US12527775, Compound I-030	5-hydroxytryptamine receptor 2A	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369011	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369011&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90115359	402365809							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192934	Cc1csc(CN(C(=O)NCc2ccc(OCC(C)C)cc2)C2CCN(C)CC2)c1	InChI=1S/C24H35N3O2S/c1-18(2)16-29-22-7-5-20(6-8-22)14-25-24(28)27(15-23-13-19(3)17-30-23)21-9-11-26(4)12-10-21/h5-8,13,17-18,21H,9-12,14-16H2,1-4H3,(H,25,28)	PIHPFLATLIGUAP-UHFFFAOYSA-N	369012	US12527775, Compound I-031	5-hydroxytryptamine receptor 2A	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369012	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369012&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90001680	402365810							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192935	CC(C)COc1ccc(CNC(=O)N(Cc2nccs2)C2CCN(C)CC2)cc1	InChI=1S/C22H32N4O2S/c1-17(2)16-28-20-6-4-18(5-7-20)14-24-22(27)26(15-21-23-10-13-29-21)19-8-11-25(3)12-9-19/h4-7,10,13,17,19H,8-9,11-12,14-16H2,1-3H3,(H,24,27)	VSMFWKPFNCUDAY-UHFFFAOYSA-N	369013	US12527775, Compound I-032	5-hydroxytryptamine receptor 2A	Homo sapiens	 55								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369013	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369013&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90001230	402365811							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192936	CC(C)COc1ccc(CNC(=O)N(Cc2ncco2)C2CCN(C)CC2)cc1	InChI=1S/C22H32N4O3/c1-17(2)16-29-20-6-4-18(5-7-20)14-24-22(27)26(15-21-23-10-13-28-21)19-8-11-25(3)12-9-19/h4-7,10,13,17,19H,8-9,11-12,14-16H2,1-3H3,(H,24,27)	KCVZHQVUDBZJAP-UHFFFAOYSA-N	369014	US12527775, Compound I-033	5-hydroxytryptamine receptor 2A	Homo sapiens	>100								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369014	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369014&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90114975	402365812							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192937	CC(C)COc1ccc(CNC(=O)N(Cc2ccns2)C2CCN(C)CC2)cc1	InChI=1S/C22H32N4O2S/c1-17(2)16-28-20-6-4-18(5-7-20)14-23-22(27)26(15-21-8-11-24-29-21)19-9-12-25(3)13-10-19/h4-8,11,17,19H,9-10,12-16H2,1-3H3,(H,23,27)	ISNWBTSZIYTFLG-UHFFFAOYSA-N	369015	US12527775, Compound I-034	5-hydroxytryptamine receptor 2A	Homo sapiens	>100								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369015	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369015&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90001178	402365813							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192938	Cc1cc(CN(C(=O)NCc2ccc(OCC(C)C)cc2)C2CCN(C)CC2)no1	InChI=1S/C23H34N4O3/c1-17(2)16-29-22-7-5-19(6-8-22)14-24-23(28)27(15-20-13-18(3)30-25-20)21-9-11-26(4)12-10-21/h5-8,13,17,21H,9-12,14-16H2,1-4H3,(H,24,28)	LYFFCNZNQDPZQW-UHFFFAOYSA-N	369016	US12527775, Compound I-035	5-hydroxytryptamine receptor 2A	Homo sapiens	 55								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369016	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369016&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90000899	402365814							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192939	Cc1nc(CN(C(=O)NCc2ccc(OCC(C)C)cc2)C2CCN(C)CC2)no1	InChI=1S/C22H33N5O3/c1-16(2)15-29-20-7-5-18(6-8-20)13-23-22(28)27(14-21-24-17(3)30-25-21)19-9-11-26(4)12-10-19/h5-8,16,19H,9-15H2,1-4H3,(H,23,28)	ZWEZYYYLDZHMGS-UHFFFAOYSA-N	369017	US12527775, Compound I-036	5-hydroxytryptamine receptor 2A	Homo sapiens	>100								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369017	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369017&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90114519	402365815							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192940	CC(C)COc1ccc(CNC(=O)N(Cc2nccc3ccccc23)C2CCN(C)CC2)cc1	InChI=1S/C28H36N4O2/c1-21(2)20-34-25-10-8-22(9-11-25)18-30-28(33)32(24-13-16-31(3)17-14-24)19-27-26-7-5-4-6-23(26)12-15-29-27/h4-12,15,21,24H,13-14,16-20H2,1-3H3,(H,30,33)	FLRJHFZZGWVKIZ-UHFFFAOYSA-N	369018	US12527775, Compound I-038	5-hydroxytryptamine receptor 2A	Homo sapiens	 55								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369018	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369018&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90114579	402365816							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192941	CC(C)COc1ccc(CNC(=O)N(Cc2cccc3ccncc23)C2CCN(C)CC2)cc1	InChI=1S/C28H36N4O2/c1-21(2)20-34-26-9-7-22(8-10-26)17-30-28(33)32(25-12-15-31(3)16-13-25)19-24-6-4-5-23-11-14-29-18-27(23)24/h4-11,14,18,21,25H,12-13,15-17,19-20H2,1-3H3,(H,30,33)	ZZOWTQXOBWYWMW-UHFFFAOYSA-N	369019	US12527775, Compound I-039	5-hydroxytryptamine receptor 2A	Homo sapiens	>100								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369019	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369019&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90115081	402365817							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192942	CC(C)COc1ccc(CNC(=O)N(Cc2cccc3cccnc23)C2CCN(C)CC2)cc1	InChI=1S/C28H36N4O2/c1-21(2)20-34-26-11-9-22(10-12-26)18-30-28(33)32(25-13-16-31(3)17-14-25)19-24-7-4-6-23-8-5-15-29-27(23)24/h4-12,15,21,25H,13-14,16-20H2,1-3H3,(H,30,33)	UXXLYNFVVYUHQB-UHFFFAOYSA-N	369020	US12527775, Compound I-040	5-hydroxytryptamine receptor 2A	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369020	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369020&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90114568	402365818							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192943	CC(C)COc1ccc(CNC(=O)N(Cc2cccc3cc[nH]c23)C2CCN(C)CC2)cc1	InChI=1S/C27H36N4O2/c1-20(2)19-33-25-9-7-21(8-10-25)17-29-27(32)31(24-12-15-30(3)16-13-24)18-23-6-4-5-22-11-14-28-26(22)23/h4-11,14,20,24,28H,12-13,15-19H2,1-3H3,(H,29,32)	FPGIWIKXPQUPSY-UHFFFAOYSA-N	369021	US12527775, Compound I-041	5-hydroxytryptamine receptor 2A	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369021	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369021&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90115480	402365819							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192944	CN1CCC(CC1)N(Cc1ccc(F)cn1)C(=O)NCc1ccc2OCCc2c1	InChI=1S/C22H27FN4O2/c1-26-9-6-20(7-10-26)27(15-19-4-3-18(23)14-24-19)22(28)25-13-16-2-5-21-17(12-16)8-11-29-21/h2-5,12,14,20H,6-11,13,15H2,1H3,(H,25,28)	PPSQBTQKEGJNIN-UHFFFAOYSA-N	631407	US20230348421, Compound 46::US12527775, Compound I-044	5-hydroxytryptamine receptor 2A	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=631407	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=631407&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			169490291	485658885							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192945	CN1CCC(N(Cc2ccc(F)cn2)C(=O)NCc2ccc3c(c2)CCCO3)CC1	InChI=1S/C23H29FN4O2/c1-27-10-8-21(9-11-27)28(16-20-6-5-19(24)15-25-20)23(29)26-14-17-4-7-22-18(13-17)3-2-12-30-22/h4-7,13,15,21H,2-3,8-12,14,16H2,1H3,(H,26,29)	BCJTVODADNLPKB-UHFFFAOYSA-N	369023	US12527775, Compound I-045	5-hydroxytryptamine receptor 2A	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369023	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369023&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90114815	402365821							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192946	CN1CCC(N(Cc2ccc(F)cn2)C(=O)NCc2ccc(OCC3CC3)cc2)CC1	InChI=1S/C24H31FN4O2/c1-28-12-10-22(11-13-28)29(16-21-7-6-20(25)15-26-21)24(30)27-14-18-4-8-23(9-5-18)31-17-19-2-3-19/h4-9,15,19,22H,2-3,10-14,16-17H2,1H3,(H,27,30)	KSDCXENHKYJIIX-UHFFFAOYSA-N	369024	US12527775, Compound I-046	5-hydroxytryptamine receptor 2A	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369024	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369024&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90114937	402365822							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192947	CCCOc1ccc(CNC(=O)N(Cc2ccc(F)cn2)C2CCN(C)CC2)cc1	InChI=1S/C23H31FN4O2/c1-3-14-30-22-8-4-18(5-9-22)15-26-23(29)28(21-10-12-27(2)13-11-21)17-20-7-6-19(24)16-25-20/h4-9,16,21H,3,10-15,17H2,1-2H3,(H,26,29)	KJDMYSQHMUGNEZ-UHFFFAOYSA-N	369025	US12527775, Compound I-047	5-hydroxytryptamine receptor 2A	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369025	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369025&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90115201	402365823							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192948	CN1CCC(N(Cc2ccc(F)cn2)C(=O)NCc2ccc(OC(F)F)cc2)CC1	InChI=1S/C21H25F3N4O2/c1-27-10-8-18(9-11-27)28(14-17-5-4-16(22)13-25-17)21(29)26-12-15-2-6-19(7-3-15)30-20(23)24/h2-7,13,18,20H,8-12,14H2,1H3,(H,26,29)	MFFWUTDXXDCBPF-UHFFFAOYSA-N	369026	US12527775, Compound I-048	5-hydroxytryptamine receptor 2A	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369026	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369026&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90114650	402365824							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192949	CC(C)COc1ccc(CNC(=O)N(Cc2ccc(F)cn2)C2CCN(C)CC2(F)F)cc1	InChI=1S/C24H31F3N4O2/c1-17(2)15-33-21-8-4-18(5-9-21)12-29-23(32)31(14-20-7-6-19(25)13-28-20)22-10-11-30(3)16-24(22,26)27/h4-9,13,17,22H,10-12,14-16H2,1-3H3,(H,29,32)	BPSHPSWTIJXILI-UHFFFAOYSA-N	369027	US12527775, Compound I-049	5-hydroxytryptamine receptor 2A	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369027	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369027&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90115437	402365825							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192950	CC(C)COc1ccc(CNC(=O)N(Cc2ccc(F)cn2)C2CCN(C)CC23CC3)cc1	InChI=1S/C26H35FN4O2/c1-19(2)17-33-23-8-4-20(5-9-23)14-29-25(32)31(16-22-7-6-21(27)15-28-22)24-10-13-30(3)18-26(24)11-12-26/h4-9,15,19,24H,10-14,16-18H2,1-3H3,(H,29,32)	HGGAPXYKOUETOQ-UHFFFAOYSA-N	369028	US12527775, Compound I-050	5-hydroxytryptamine receptor 2A	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369028	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369028&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90114257	402365826							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192951	CC(C)COc1ccc(CNC(=O)N(Cc2ccc(F)cn2)C2CCNCC23CC3)cc1	InChI=1S/C25H33FN4O2/c1-18(2)16-32-22-7-3-19(4-8-22)13-29-24(31)30(15-21-6-5-20(26)14-28-21)23-9-12-27-17-25(23)10-11-25/h3-8,14,18,23,27H,9-13,15-17H2,1-2H3,(H,29,31)	PRFDXHWUJFCOLY-UHFFFAOYSA-N	369029	US12527775, Compound I-051	5-hydroxytryptamine receptor 2A	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369029	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369029&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90114318	402365827							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192952	CC(C)COc1ccc(CNC(=O)N(Cc2ccc(F)cn2)[C@@H]2CCN3CCC[C@@H]3C2)cc1	InChI=1S/C26H35FN4O2/c1-19(2)18-33-25-9-5-20(6-10-25)15-29-26(32)31(17-22-8-7-21(27)16-28-22)24-11-13-30-12-3-4-23(30)14-24/h5-10,16,19,23-24H,3-4,11-15,17-18H2,1-2H3,(H,29,32)	GWOGXDIRRJDHMT-UHFFFAOYSA-N	369030	US12527775, Compound I-052	5-hydroxytryptamine receptor 2A	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369030	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369030&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90115291	402365828							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192953	CC(C)COc1ccc(CNC(=O)N(Cc2ccc(F)cn2)[C@@H]2CCN3CCC[C@H]3C2)cc1	InChI=1S/C26H35FN4O2/c1-19(2)18-33-25-9-5-20(6-10-25)15-29-26(32)31(17-22-8-7-21(27)16-28-22)24-11-13-30-12-3-4-23(30)14-24/h5-10,16,19,23-24H,3-4,11-15,17-18H2,1-2H3,(H,29,32)	GWOGXDIRRJDHMT-UHFFFAOYSA-N	369031	US12527775, Compound I-053	5-hydroxytryptamine receptor 2A	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369031	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369031&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90114667	402365829							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192954	O=C(NCc1ccc(OC(F)F)cc1)N(Cc1ccc(F)cn1)[C@@H]1CCNC[C@@H]1F	InChI=1S/C20H22F4N4O2/c21-14-3-4-15(26-10-14)12-28(18-7-8-25-11-17(18)22)20(29)27-9-13-1-5-16(6-2-13)30-19(23)24/h1-6,10,17-19,25H,7-9,11-12H2,(H,27,29)	KSUJAUJCXHKBOR-UHFFFAOYSA-N	369032	US12527775, Compound I-054	5-hydroxytryptamine receptor 2A	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369032	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369032&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90114574	402365830							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192955	CN1CC[C@@H](N(Cc2ccc(F)cn2)C(=O)NCc2ccc(OC(F)F)cc2)[C@@H](F)C1	InChI=1S/C21H24F4N4O2/c1-28-9-8-19(18(23)13-28)29(12-16-5-4-15(22)11-26-16)21(30)27-10-14-2-6-17(7-3-14)31-20(24)25/h2-7,11,18-20H,8-10,12-13H2,1H3,(H,27,30)	DGHDMWYXYQSLON-UHFFFAOYSA-N	369033	US12527775, Compound I-055	5-hydroxytryptamine receptor 2A	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369033	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369033&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90114086	402365831							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192956	CCCOc1ccc(CNC(=O)N(Cc2ccc(F)cn2)[C@@H]2CCNC[C@@H]2F)cc1	InChI=1S/C22H28F2N4O2/c1-2-11-30-19-7-3-16(4-8-19)12-27-22(29)28(21-9-10-25-14-20(21)24)15-18-6-5-17(23)13-26-18/h3-8,13,20-21,25H,2,9-12,14-15H2,1H3,(H,27,29)	ZFBKJFMKDYQXOV-UHFFFAOYSA-N	369034	US12527775, Compound I-056	5-hydroxytryptamine receptor 2A	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369034	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369034&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90114441	402365832							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192957	CCCOc1ccc(CNC(=O)N(Cc2ccc(F)cn2)[C@@H]2CCN(C)C[C@@H]2F)cc1	InChI=1S/C23H30F2N4O2/c1-3-12-31-20-8-4-17(5-9-20)13-27-23(30)29(15-19-7-6-18(24)14-26-19)22-10-11-28(2)16-21(22)25/h4-9,14,21-22H,3,10-13,15-16H2,1-2H3,(H,27,30)	IEBKHWQGGYMJFB-UHFFFAOYSA-N	369035	US12527775, Compound I-057	5-hydroxytryptamine receptor 2A	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369035	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369035&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90114664	402365833							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192958	CC(C)COc1ccc(CNC(=O)N(Cc2ccc(F)cn2)[C@@H]2CCNC[C@@H]2F)cc1	InChI=1S/C23H30F2N4O2/c1-16(2)15-31-20-7-3-17(4-8-20)11-28-23(30)29(22-9-10-26-13-21(22)25)14-19-6-5-18(24)12-27-19/h3-8,12,16,21-22,26H,9-11,13-15H2,1-2H3,(H,28,30)	WAIOOCMTXRBLQC-UHFFFAOYSA-N	369036	US12527775, Compound I-058	5-hydroxytryptamine receptor 2A	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369036	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369036&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90115290	402365834							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192959	CC(C)COc1ccc(CNC(=O)N(Cc2ccc(F)cn2)[C@@H]2CCN(C)C[C@@H]2F)cc1	InChI=1S/C24H32F2N4O2/c1-17(2)16-32-21-8-4-18(5-9-21)12-28-24(31)30(14-20-7-6-19(25)13-27-20)23-10-11-29(3)15-22(23)26/h4-9,13,17,22-23H,10-12,14-16H2,1-3H3,(H,28,31)	RELRUDTWGGXBJF-UHFFFAOYSA-N	369037	US12527775, Compound I-059	5-hydroxytryptamine receptor 2A	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369037	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369037&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90115009	402365835							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192960	COc1ccc(CNC(=O)N(Cc2ccc(F)cn2)C2CCNCC23CC3)cc1	InChI=1S/C22H27FN4O2/c1-29-19-6-2-16(3-7-19)12-26-21(28)27(14-18-5-4-17(23)13-25-18)20-8-11-24-15-22(20)9-10-22/h2-7,13,20,24H,8-12,14-15H2,1H3,(H,26,28)	HSDJYQCCXZKKAQ-UHFFFAOYSA-N	369038	US12527775, Compound I-060	5-hydroxytryptamine receptor 2A	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369038	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369038&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90114894	402365836							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192961	COc1ccc(CNC(=O)N(Cc2ccc(F)cn2)C2CCN(C)CC23CC3)cc1	InChI=1S/C23H29FN4O2/c1-27-12-9-21(23(16-27)10-11-23)28(15-19-6-5-18(24)14-25-19)22(29)26-13-17-3-7-20(30-2)8-4-17/h3-8,14,21H,9-13,15-16H2,1-2H3,(H,26,29)	QWGQPPNQHPIMAS-UHFFFAOYSA-N	369039	US12527775, Compound I-061	5-hydroxytryptamine receptor 2A	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369039	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369039&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90115415	402365837							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192962	CCCOc1ccc(CNC(=O)N(Cc2ccc(F)cn2)C2CCNCC23CC3)cc1	InChI=1S/C24H31FN4O2/c1-2-13-31-21-7-3-18(4-8-21)14-28-23(30)29(16-20-6-5-19(25)15-27-20)22-9-12-26-17-24(22)10-11-24/h3-8,15,22,26H,2,9-14,16-17H2,1H3,(H,28,30)	BDTWDALLCFDLQP-UHFFFAOYSA-N	369040	US12527775, Compound I-062	5-hydroxytryptamine receptor 2A	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369040	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369040&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90114962	402365838							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192963	CCCOc1ccc(CNC(=O)N(Cc2ccc(F)cn2)C2CCN(C)CC23CC3)cc1	InChI=1S/C25H33FN4O2/c1-3-14-32-22-8-4-19(5-9-22)15-28-24(31)30(17-21-7-6-20(26)16-27-21)23-10-13-29(2)18-25(23)11-12-25/h4-9,16,23H,3,10-15,17-18H2,1-2H3,(H,28,31)	HTMVOJQJHVQXIO-UHFFFAOYSA-N	369041	US12527775, Compound I-063	5-hydroxytryptamine receptor 2A	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369041	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369041&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90115121	402365839							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192964	CC(C)COc1ccc(CNC(=O)N(Cc2ccn(C)n2)C2CCN(C)CC23CC3)cc1	InChI=1S/C25H37N5O2/c1-19(2)17-32-22-7-5-20(6-8-22)15-26-24(31)30(16-21-9-14-29(4)27-21)23-10-13-28(3)18-25(23)11-12-25/h5-9,14,19,23H,10-13,15-18H2,1-4H3,(H,26,31)	LIQILROYDQMRBR-UHFFFAOYSA-N	369042	US12527775, Compound I-064	5-hydroxytryptamine receptor 2A	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369042	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369042&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90114617	402365840							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192965	CCCOc1ccc(CNC(=O)N(Cc2ccn(C)n2)C2CCN(C)CC23CC3)cc1	InChI=1S/C24H35N5O2/c1-4-15-31-21-7-5-19(6-8-21)16-25-23(30)29(17-20-9-14-28(3)26-20)22-10-13-27(2)18-24(22)11-12-24/h5-9,14,22H,4,10-13,15-18H2,1-3H3,(H,25,30)	HOVLTWZHAUDSGN-UHFFFAOYSA-N	369043	US12527775, Compound I-065	5-hydroxytryptamine receptor 2A	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369043	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369043&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90114854	402365841							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192966	O=C(NCc1ccc(OCC2CC2)cc1)N(Cc1ccc(F)cn1)C1CCNCC12CC2	InChI=1S/C25H31FN4O2/c26-20-5-6-21(28-14-20)15-30(23-9-12-27-17-25(23)10-11-25)24(31)29-13-18-3-7-22(8-4-18)32-16-19-1-2-19/h3-8,14,19,23,27H,1-2,9-13,15-17H2,(H,29,31)	MFQJPPKXTFIDCS-UHFFFAOYSA-N	369044	US12527775, Compound I-066	5-hydroxytryptamine receptor 2A	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369044	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369044&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90115173	402365842							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192967	CN1CCC(N(Cc2ccc(F)cn2)C(=O)NCc2ccc(OCC3CC3)cc2)C2(CC2)C1	InChI=1S/C26H33FN4O2/c1-30-13-10-24(26(18-30)11-12-26)31(16-22-7-6-21(27)15-28-22)25(32)29-14-19-4-8-23(9-5-19)33-17-20-2-3-20/h4-9,15,20,24H,2-3,10-14,16-18H2,1H3,(H,29,32)	XKYAGYGTSUAWDO-UHFFFAOYSA-N	369045	US12527775, Compound I-067	5-hydroxytryptamine receptor 2A	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369045	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369045&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90114543	402365843							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192968	CC(C)COc1ccc(CNC(=O)N(Cc2ncccc2F)[C@@H]2CCN(C)C[C@@H]2F)cc1	InChI=1S/C24H32F2N4O2/c1-17(2)16-32-19-8-6-18(7-9-19)13-28-24(31)30(15-22-20(25)5-4-11-27-22)23-10-12-29(3)14-21(23)26/h4-9,11,17,21,23H,10,12-16H2,1-3H3,(H,28,31)	BFJPGRVEPQGNKG-UHFFFAOYSA-N	369046	US12527775, Compound I-069	5-hydroxytryptamine receptor 2A	Homo sapiens	 55								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369046	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369046&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90001568	402365844							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192969	CC(C)COc1ccc(CNC(=O)N(Cc2ccc(F)c3cccnc23)C2CCN(C)CC2)cc1	InChI=1S/C28H35FN4O2/c1-20(2)19-35-24-9-6-21(7-10-24)17-31-28(34)33(23-12-15-32(3)16-13-23)18-22-8-11-26(29)25-5-4-14-30-27(22)25/h4-11,14,20,23H,12-13,15-19H2,1-3H3,(H,31,34)	QAXKVARPGQRGFE-UHFFFAOYSA-N	369047	US12527775, Compound I-070	5-hydroxytryptamine receptor 2A	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369047	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369047&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90001583	402365845							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192970	CC(C)COc1ccc(CNC(=O)N(Cc2ncccc2F)[C@@H]2CCNC[C@@H]2F)cc1	InChI=1S/C23H30F2N4O2/c1-16(2)15-31-18-7-5-17(6-8-18)12-28-23(30)29(22-9-11-26-13-20(22)25)14-21-19(24)4-3-10-27-21/h3-8,10,16,20,22,26H,9,11-15H2,1-2H3,(H,28,30)	XKSZKJUILWLDNC-UHFFFAOYSA-N	369048	US12527775, Compound I-073	5-hydroxytryptamine receptor 2A	Homo sapiens	 55								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369048	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369048&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90000883	402365846							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192971	CC(C)COc1ccc(CNC(=O)N(Cc2cn(C)c3cccnc23)C2CCN(C)CC2)cc1	InChI=1S/C27H37N5O2/c1-20(2)19-34-24-9-7-21(8-10-24)16-29-27(33)32(23-11-14-30(3)15-12-23)18-22-17-31(4)25-6-5-13-28-26(22)25/h5-10,13,17,20,23H,11-12,14-16,18-19H2,1-4H3,(H,29,33)	FIQTZPQWSUGONN-UHFFFAOYSA-N	369049	US12527775, Compound I-074	5-hydroxytryptamine receptor 2A	Homo sapiens	 55								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369049	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369049&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90001154	402365847							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192972	CC(C)COc1ccc(CNC(=O)N(Cc2ncc(O)cc2F)C2CCN(C)CC2)cc1	InChI=1S/C24H33FN4O3/c1-17(2)16-32-21-6-4-18(5-7-21)13-27-24(31)29(19-8-10-28(3)11-9-19)15-23-22(25)12-20(30)14-26-23/h4-7,12,14,17,19,30H,8-11,13,15-16H2,1-3H3,(H,27,31)	RDZRYWBMFPMUKT-UHFFFAOYSA-N	369050	US12527775, Compound I-077	5-hydroxytryptamine receptor 2A	Homo sapiens	 55								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369050	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369050&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90001141	402365848							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192973	Cc1cnc(CN(C(=O)NCc2ccc(OCC(C)C)cc2)C2CCN(C)CC2)cn1	InChI=1S/C24H35N5O2/c1-18(2)17-31-23-7-5-20(6-8-23)14-27-24(30)29(22-9-11-28(4)12-10-22)16-21-15-25-19(3)13-26-21/h5-8,13,15,18,22H,9-12,14,16-17H2,1-4H3,(H,27,30)	GPOHSDBYYDCRNX-UHFFFAOYSA-N	369051	US12527775, Compound I-078	5-hydroxytryptamine receptor 2A	Homo sapiens	 55								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369051	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369051&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90001897	402365849							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192974	CC(C)COc1ccc(CNC(=O)N(Cc2cn(C)c3ccccc23)C2CCN(C)CC2)cc1	InChI=1S/C28H38N4O2/c1-21(2)20-34-25-11-9-22(10-12-25)17-29-28(33)32(24-13-15-30(3)16-14-24)19-23-18-31(4)27-8-6-5-7-26(23)27/h5-12,18,21,24H,13-17,19-20H2,1-4H3,(H,29,33)	OVLSMBMUUVSBKE-UHFFFAOYSA-N	369052	US12527775, Compound I-079	5-hydroxytryptamine receptor 2A	Homo sapiens	>100								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369052	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369052&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90001674	402365850							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192975	CC(C)COc1ccc(CNC(=O)N(Cc2ncc(F)cc2O)C2CCN(C)CC2)cc1	InChI=1S/C24H33FN4O3/c1-17(2)16-32-21-6-4-18(5-7-21)13-27-24(31)29(20-8-10-28(3)11-9-20)15-22-23(30)12-19(25)14-26-22/h4-7,12,14,17,20,30H,8-11,13,15-16H2,1-3H3,(H,27,31)	JVQQJSQFDKFGQG-UHFFFAOYSA-N	369053	US12527775, Compound I-080	5-hydroxytryptamine receptor 2A	Homo sapiens	 55								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369053	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369053&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90115113	402365851							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192976	CC(C)COc1ccc(CNC(=O)N(Cc2ccc(F)c3cc[nH]c23)C2CCN(C)CC2)cc1	InChI=1S/C27H35FN4O2/c1-19(2)18-34-23-7-4-20(5-8-23)16-30-27(33)32(22-11-14-31(3)15-12-22)17-21-6-9-25(28)24-10-13-29-26(21)24/h4-10,13,19,22,29H,11-12,14-18H2,1-3H3,(H,30,33)	PQUWOVGMBSCSIR-UHFFFAOYSA-N	369054	US12527775, Compound I-081	5-hydroxytryptamine receptor 2A	Homo sapiens	>100								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369054	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369054&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90114502	402365852							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192977	C=Cc1ccc(CNC(=O)N(Cc2ccc(F)cn2)C2CCN(C)CC2)cc1	InChI=1S/C22H27FN4O/c1-3-17-4-6-18(7-5-17)14-25-22(28)27(21-10-12-26(2)13-11-21)16-20-9-8-19(23)15-24-20/h3-9,15,21H,1,10-14,16H2,2H3,(H,25,28)	WMWKGQVFSOQGDY-UHFFFAOYSA-N	369055	US12527775, Compound I-083	5-hydroxytryptamine receptor 2A	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369055	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369055&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90114928	402365853							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192978	CCCOc1ccc(CNC(=O)N(Cc2ccn(C)n2)[C@@H]2CCN(C)CC23CC3)cc1	InChI=1S/C24H35N5O2/c1-4-15-31-21-7-5-19(6-8-21)16-25-23(30)29(17-20-9-14-28(3)26-20)22-10-13-27(2)18-24(22)11-12-24/h5-9,14,22H,4,10-13,15-18H2,1-3H3,(H,25,30)	HOVLTWZHAUDSGN-UHFFFAOYSA-N	369056	US12527775, Compound I-086	5-hydroxytryptamine receptor 2A	Homo sapiens	>100								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369056	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369056&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90114769	402365854							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192979	CC(C)COc1ccc(CNC(=O)N(Cc2ccn(C)n2)[C@@H]2CCN(C)CC23CC3)cc1	InChI=1S/C25H37N5O2/c1-19(2)17-32-22-7-5-20(6-8-22)15-26-24(31)30(16-21-9-14-29(4)27-21)23-10-13-28(3)18-25(23)11-12-25/h5-9,14,19,23H,10-13,15-18H2,1-4H3,(H,26,31)	LIQILROYDQMRBR-UHFFFAOYSA-N	369057	US12527775, Compound I-087	5-hydroxytryptamine receptor 2A	Homo sapiens	>100								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369057	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369057&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90115141	402365855							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192980	CC(C)COc1ccc(CNC(=O)N(Cc2ccc(F)cn2)C2CCN(C)C(CO)C2)cc1	InChI=1S/C25H35FN4O3/c1-18(2)17-33-24-8-4-19(5-9-24)13-28-25(32)30(15-21-7-6-20(26)14-27-21)22-10-11-29(3)23(12-22)16-31/h4-9,14,18,22-23,31H,10-13,15-17H2,1-3H3,(H,28,32)	HXXWCRJKNCZJSE-UHFFFAOYSA-N	369058	US12527775, Compound I-089	5-hydroxytryptamine receptor 2A	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369058	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369058&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90114452	402365856							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192981	CC(C)COc1ccc(CNC(=O)N(Cc2ccn(C)n2)C2CCNCC23CC3)cc1	InChI=1S/C24H35N5O2/c1-18(2)16-31-21-6-4-19(5-7-21)14-26-23(30)29(15-20-9-13-28(3)27-20)22-8-12-25-17-24(22)10-11-24/h4-7,9,13,18,22,25H,8,10-12,14-17H2,1-3H3,(H,26,30)	LCEUKLLCELNFRI-UHFFFAOYSA-N	369059	US12527775, Compound I-090	5-hydroxytryptamine receptor 2A	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369059	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369059&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90115062	402365857							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192982	CC(C)COc1ccc(CNC(=O)N(Cc2ccc(F)cn2)C2CCNCC2(F)F)cc1	InChI=1S/C23H29F3N4O2/c1-16(2)14-32-20-7-3-17(4-8-20)11-29-22(31)30(13-19-6-5-18(24)12-28-19)21-9-10-27-15-23(21,25)26/h3-8,12,16,21,27H,9-11,13-15H2,1-2H3,(H,29,31)	UDGIUWDEFGCBPL-UHFFFAOYSA-N	369060	US12527775, Compound I-091	5-hydroxytryptamine receptor 2A	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369060	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369060&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90114389	402365858							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192983	CN1CCC(N(Cc2ccc(F)cn2)C(=O)NCc2ccc(OCC(C)(F)F)cc2)CC1	InChI=1S/C23H29F3N4O2/c1-23(25,26)16-32-21-7-3-17(4-8-21)13-28-22(31)30(20-9-11-29(2)12-10-20)15-19-6-5-18(24)14-27-19/h3-8,14,20H,9-13,15-16H2,1-2H3,(H,28,31)	OOZJVBZAJFDWPM-UHFFFAOYSA-N	369061	US12527775, Compound I-092	5-hydroxytryptamine receptor 2A	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369061	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369061&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90114431	402365859							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192984	CC(C)COc1ccc(CNC(=O)N(Cc2ccn(C)c2)[C@@H]2CCNC[C@@H]2F)cc1	InChI=1S/C23H33FN4O2/c1-17(2)16-30-20-6-4-18(5-7-20)12-26-23(29)28(15-19-9-11-27(3)14-19)22-8-10-25-13-21(22)24/h4-7,9,11,14,17,21-22,25H,8,10,12-13,15-16H2,1-3H3,(H,26,29)	WXBLNXYIJLJMGY-UHFFFAOYSA-N	369062	US12527775, Compound I-093	5-hydroxytryptamine receptor 2A	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369062	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369062&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90114899	402365860							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192985	Cc1cc(CN(C(=O)NCc2ccc(OCC(C)C)cc2)C2CCN(C)CC23CC3)nn1C	InChI=1S/C26H39N5O2/c1-19(2)17-33-23-8-6-21(7-9-23)15-27-25(32)31(16-22-14-20(3)30(5)28-22)24-10-13-29(4)18-26(24)11-12-26/h6-9,14,19,24H,10-13,15-18H2,1-5H3,(H,27,32)	UPJOFLCBVKGEMD-UHFFFAOYSA-N	369063	US12527775, Compound I-094	5-hydroxytryptamine receptor 2A	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369063	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369063&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90114885	402365861							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192986	CN1CCC(CC1)N(Cc1ccc(F)cn1)C(=O)NCc1ccc(OCC(F)(F)F)cc1	InChI=1S/C22H26F4N4O2/c1-29-10-8-19(9-11-29)30(14-18-5-4-17(23)13-27-18)21(31)28-12-16-2-6-20(7-3-16)32-15-22(24,25)26/h2-7,13,19H,8-12,14-15H2,1H3,(H,28,31)	HCPZGSLTHYYAJZ-UHFFFAOYSA-N	50596723	CHEMBL5205903::US20230348421, Compound 59::US12527775, Compound I-095	5-hydroxytryptamine receptor 2A	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50596723	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50596723&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			168286940	482607575							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192987	Cc1cc(CN(C(=O)NCc2ccc(OCC(C)C)cc2)C2CCN(C)CC2)nn1C	InChI=1S/C24H37N5O2/c1-18(2)17-31-23-8-6-20(7-9-23)15-25-24(30)29(22-10-12-27(4)13-11-22)16-21-14-19(3)28(5)26-21/h6-9,14,18,22H,10-13,15-17H2,1-5H3,(H,25,30)	XCTQDZOAWGTATR-UHFFFAOYSA-N	369065	US12527775, Compound I-096	5-hydroxytryptamine receptor 2A	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369065	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369065&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90115434	402365863							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192988	C[C@H](F)COc1ccc(CNC(=O)N(Cc2ccc(F)cn2)C2CCN(C)CC2)cc1	InChI=1S/C23H30F2N4O2/c1-17(24)16-31-22-7-3-18(4-8-22)13-27-23(30)29(21-9-11-28(2)12-10-21)15-20-6-5-19(25)14-26-20/h3-8,14,17,21H,9-13,15-16H2,1-2H3,(H,27,30)	UXWCRWYGIJZKIL-UHFFFAOYSA-N	369066	US12527775, Compound I-097	5-hydroxytryptamine receptor 2A	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369066	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369066&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90114315	402365864							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192989	C[C@@H](F)COc1ccc(CNC(=O)N(Cc2ccc(F)cn2)C2CCN(C)CC2)cc1	InChI=1S/C23H30F2N4O2/c1-17(24)16-31-22-7-3-18(4-8-22)13-27-23(30)29(21-9-11-28(2)12-10-21)15-20-6-5-19(25)14-26-20/h3-8,14,17,21H,9-13,15-16H2,1-2H3,(H,27,30)	UXWCRWYGIJZKIL-UHFFFAOYSA-N	369067	US12527775, Compound I-098	5-hydroxytryptamine receptor 2A	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369067	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369067&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90114378	402365865							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192990	COc1ccc(CNC(=O)N(Cc2ccc(F)cn2)C2CCN(C)CC23CC3)cc1	InChI=1S/C23H29FN4O2/c1-27-12-9-21(23(16-27)10-11-23)28(15-19-6-5-18(24)14-25-19)22(29)26-13-17-3-7-20(30-2)8-4-17/h3-8,14,21H,9-13,15-16H2,1-2H3,(H,26,29)	QWGQPPNQHPIMAS-UHFFFAOYSA-N	369068	US12527775, Compound I-099	5-hydroxytryptamine receptor 2A	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369068	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369068&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90115381	402365866							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192991	Cc1ccc(CNC(=O)N(Cc2ccc(F)cn2)C2CCN(C)CC23CC3)cc1	InChI=1S/C23H29FN4O/c1-17-3-5-18(6-4-17)13-26-22(29)28(15-20-8-7-19(24)14-25-20)21-9-12-27(2)16-23(21)10-11-23/h3-8,14,21H,9-13,15-16H2,1-2H3,(H,26,29)	FKFURHGVBTVPEX-UHFFFAOYSA-N	369069	US12527775, Compound I-100	5-hydroxytryptamine receptor 2A	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369069	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369069&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90114547	402365867							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192992	Cc1ccc(CNC(=O)N(Cc2ccc(F)cn2)C2CCNCC23CC3)cc1	InChI=1S/C22H27FN4O/c1-16-2-4-17(5-3-16)12-26-21(28)27(14-19-7-6-18(23)13-25-19)20-8-11-24-15-22(20)9-10-22/h2-7,13,20,24H,8-12,14-15H2,1H3,(H,26,28)	JOJQHCHWEBXDFA-UHFFFAOYSA-N	369070	US12527775, Compound I-101	5-hydroxytryptamine receptor 2A	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369070	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369070&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90115355	402365868							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192993	CC(C)COc1ccc(CNC(=O)N(Cc2ccc(F)cn2)[C@H]2CCN(C)C[C@H]2F)cc1	InChI=1S/C24H32F2N4O2/c1-17(2)16-32-21-8-4-18(5-9-21)12-28-24(31)30(14-20-7-6-19(25)13-27-20)23-10-11-29(3)15-22(23)26/h4-9,13,17,22-23H,10-12,14-16H2,1-3H3,(H,28,31)	RELRUDTWGGXBJF-UHFFFAOYSA-N	369071	US12527775, Compound I-103	5-hydroxytryptamine receptor 2A	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369071	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369071&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90114595	402365869							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192994	COc1ccc(CNC(=O)N(Cc2cc(C)n(C)n2)C2CCN(C)CC23CC3)cc1	InChI=1S/C23H33N5O2/c1-17-13-19(25-27(17)3)15-28(21-9-12-26(2)16-23(21)10-11-23)22(29)24-14-18-5-7-20(30-4)8-6-18/h5-8,13,21H,9-12,14-16H2,1-4H3,(H,24,29)	OSXJWIZOZORKAS-UHFFFAOYSA-N	369072	US12527775, Compound I-104	5-hydroxytryptamine receptor 2A	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369072	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369072&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90113978	402365870							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207870	Cc1ccc(CNC(=O)N(Cc2cc(C)n(C)n2)C2CCN(C)CC23CC3)cc1	InChI=1S/C23H33N5O/c1-17-5-7-19(8-6-17)14-24-22(29)28(15-20-13-18(2)27(4)25-20)21-9-12-26(3)16-23(21)10-11-23/h5-8,13,21H,9-12,14-16H2,1-4H3,(H,24,29)	PGAZILYDJHZGLJ-UHFFFAOYSA-N	369073	US12527775, Compound I-105	5-hydroxytryptamine receptor 2A	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369073	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369073&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90114686	402365871							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207871	COc1ccc(COC(=O)N(Cc2ccn(C)c2)C2CCN(C)CC2)cc1	InChI=1S/C21H29N3O3/c1-22-12-9-19(10-13-22)24(15-18-8-11-23(2)14-18)21(25)27-16-17-4-6-20(26-3)7-5-17/h4-8,11,14,19H,9-10,12-13,15-16H2,1-3H3	OCQAPICTWWOQTQ-UHFFFAOYSA-N	369074	US12527775, Compound I-106	5-hydroxytryptamine receptor 2A	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369074	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369074&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90114963	402365872							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207872	CCCOc1ccc(CNC(=O)N(Cc2ccn(C)n2)C2CCNCC23CC3)cc1	InChI=1S/C23H33N5O2/c1-3-14-30-20-6-4-18(5-7-20)15-25-22(29)28(16-19-9-13-27(2)26-19)21-8-12-24-17-23(21)10-11-23/h4-7,9,13,21,24H,3,8,10-12,14-17H2,1-2H3,(H,25,29)	KZFQBYVIYNQALR-UHFFFAOYSA-N	369075	US12527775, Compound I-107	5-hydroxytryptamine receptor 2A	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369075	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369075&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90114811	402365873							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207873	CC(C)COc1ccc(CNC(=O)N(Cc2ccn(C)c2)[C@@H]2CCN(C)C[C@@H]2F)cc1	InChI=1S/C24H35FN4O2/c1-18(2)17-31-21-7-5-19(6-8-21)13-26-24(30)29(15-20-9-11-27(3)14-20)23-10-12-28(4)16-22(23)25/h5-9,11,14,18,22-23H,10,12-13,15-17H2,1-4H3,(H,26,30)	GVKKJHCFUNJLAI-UHFFFAOYSA-N	369076	US12527775, Compound I-108	5-hydroxytryptamine receptor 2A	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369076	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369076&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			89993998	402365874							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207874	CCCOc1ccc(CNC(=O)N(Cc2cc(C)n(C)n2)C2CCN(C)CC23CC3)cc1	InChI=1S/C25H37N5O2/c1-5-14-32-22-8-6-20(7-9-22)16-26-24(31)30(17-21-15-19(2)29(4)27-21)23-10-13-28(3)18-25(23)11-12-25/h6-9,15,23H,5,10-14,16-18H2,1-4H3,(H,26,31)	BOKIASHIRMLMKK-UHFFFAOYSA-N	369077	US12527775, Compound I-109	5-hydroxytryptamine receptor 2A	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369077	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369077&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90115036	402365875							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207875	CN1CCC(N(Cc2ccn(C)n2)C(=O)NCc2ccc(OCC3CC3)cc2)C2(CC2)C1	InChI=1S/C25H35N5O2/c1-28-13-10-23(25(18-28)11-12-25)30(16-21-9-14-29(2)27-21)24(31)26-15-19-5-7-22(8-6-19)32-17-20-3-4-20/h5-9,14,20,23H,3-4,10-13,15-18H2,1-2H3,(H,26,31)	ILDRACNCXJXBPV-UHFFFAOYSA-N	369078	US12527775, Compound I-110	5-hydroxytryptamine receptor 2A	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369078	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369078&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90114180	402365876							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207876	CN1CCC(N(Cc2ccn(C)n2)C(=O)NCc2ccc(OC(F)F)cc2)C2(CC2)C1	InChI=1S/C22H29F2N5O2/c1-27-11-8-19(22(15-27)9-10-22)29(14-17-7-12-28(2)26-17)21(30)25-13-16-3-5-18(6-4-16)31-20(23)24/h3-7,12,19-20H,8-11,13-15H2,1-2H3,(H,25,30)	OFFWBFAGOYTFBS-UHFFFAOYSA-N	369079	US12527775, Compound I-111	5-hydroxytryptamine receptor 2A	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369079	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369079&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90114354	402365877							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207877	CC(C)CNc1ccc(CNC(=O)N(Cc2ccc(F)cn2)C2CCN(C)CC2)cc1	InChI=1S/C24H34FN5O/c1-18(2)14-26-21-7-4-19(5-8-21)15-28-24(31)30(23-10-12-29(3)13-11-23)17-22-9-6-20(25)16-27-22/h4-9,16,18,23,26H,10-15,17H2,1-3H3,(H,28,31)	HLCSDQGWTAVIIG-UHFFFAOYSA-N	369080	US12527775, Compound I-112	5-hydroxytryptamine receptor 2A	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369080	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369080&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90114874	402365878							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207878	CN1CCC(N(Cc2ccc(F)cn2)C(=O)NCc2ccc(OC3CC3)cc2)CC1	InChI=1S/C23H29FN4O2/c1-27-12-10-20(11-13-27)28(16-19-5-4-18(24)15-25-19)23(29)26-14-17-2-6-21(7-3-17)30-22-8-9-22/h2-7,15,20,22H,8-14,16H2,1H3,(H,26,29)	ABISKCRCWSKHNS-UHFFFAOYSA-N	369081	US12527775, Compound I-113	5-hydroxytryptamine receptor 2A	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369081	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369081&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90115264	402365879							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207879	CC(C)COc1ccc(CNC(=O)N(Cc2ccn(C)n2)[C@H]2CCN(C)CC23CC3)cc1	InChI=1S/C25H37N5O2/c1-19(2)17-32-22-7-5-20(6-8-22)15-26-24(31)30(16-21-9-14-29(4)27-21)23-10-13-28(3)18-25(23)11-12-25/h5-9,14,19,23H,10-13,15-18H2,1-4H3,(H,26,31)	LIQILROYDQMRBR-UHFFFAOYSA-N	50645460	CHEMBL5569065::US12527775, Compound I-114	5-hydroxytryptamine receptor 2A	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50645460	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50645460&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			169811703	519660862							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207880	CC(C)COc1ccc(CNC(=O)N(Cc2ccc(F)cn2)[C@H]2CCNC[C@H]2F)cc1	InChI=1S/C23H30F2N4O2/c1-16(2)15-31-20-7-3-17(4-8-20)11-28-23(30)29(22-9-10-26-13-21(22)25)14-19-6-5-18(24)12-27-19/h3-8,12,16,21-22,26H,9-11,13-15H2,1-2H3,(H,28,30)	WAIOOCMTXRBLQC-UHFFFAOYSA-N	369083	US12527775, Compound I-115	5-hydroxytryptamine receptor 2A	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369083	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369083&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90114394	402365881							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207881	CN1CCC(N(Cc2ccc(F)cn2)C(=O)NCc2ccc(OCC(F)(F)C(F)F)cc2)CC1	InChI=1S/C23H27F5N4O2/c1-31-10-8-19(9-11-31)32(14-18-5-4-17(24)13-29-18)22(33)30-12-16-2-6-20(7-3-16)34-15-23(27,28)21(25)26/h2-7,13,19,21H,8-12,14-15H2,1H3,(H,30,33)	ZWFQFKQAPWDFPL-UHFFFAOYSA-N	369084	US12527775, Compound I-117	5-hydroxytryptamine receptor 2A	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369084	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369084&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90114191	402365882							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207882	CC(C)COc1ccc(CNC(=O)N(Cc2ccn(C(F)F)n2)C2CCN(C)CC2)cc1	InChI=1S/C23H33F2N5O2/c1-17(2)16-32-21-6-4-18(5-7-21)14-26-23(31)29(20-9-11-28(3)12-10-20)15-19-8-13-30(27-19)22(24)25/h4-8,13,17,20,22H,9-12,14-16H2,1-3H3,(H,26,31)	SKLASZRMEYXCFM-UHFFFAOYSA-N	369085	US12527775, Compound I-118	5-hydroxytryptamine receptor 2A	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369085	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369085&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90114462	402365883							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207883	CCCOc1ccc(CNC(=O)N(Cc2ccc(F)cn2)[C@H]2CCNC[C@H]2F)cc1	InChI=1S/C22H28F2N4O2/c1-2-11-30-19-7-3-16(4-8-19)12-27-22(29)28(21-9-10-25-14-20(21)24)15-18-6-5-17(23)13-26-18/h3-8,13,20-21,25H,2,9-12,14-15H2,1H3,(H,27,29)	ZFBKJFMKDYQXOV-UHFFFAOYSA-N	369086	US12527775, Compound I-119	5-hydroxytryptamine receptor 2A	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369086	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369086&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90114395	402365884							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207884	Cc1ccc(CNC(=O)N(Cc2ccc(F)cn2)[C@H]2CCN(C)CC23CC3)cc1	InChI=1S/C23H29FN4O/c1-17-3-5-18(6-4-17)13-26-22(29)28(15-20-8-7-19(24)14-25-20)21-9-12-27(2)16-23(21)10-11-23/h3-8,14,21H,9-13,15-16H2,1-2H3,(H,26,29)	FKFURHGVBTVPEX-UHFFFAOYSA-N	369087	US12527775, Compound I-120	5-hydroxytryptamine receptor 2A	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369087	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369087&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90114747	402365885							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207885	CN1CCC(N(Cc2ccc(F)cn2)C(=O)NCc2ccc(N(C)C)cc2)CC1	InChI=1S/C22H30FN5O/c1-26(2)20-8-4-17(5-9-20)14-25-22(29)28(21-10-12-27(3)13-11-21)16-19-7-6-18(23)15-24-19/h4-9,15,21H,10-14,16H2,1-3H3,(H,25,29)	TYQZCRCTMUNSFI-UHFFFAOYSA-N	369088	US12527775, Compound I-121	5-hydroxytryptamine receptor 2A	Homo sapiens	 55								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369088	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369088&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90114177	402365886							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207886	CCCOc1ccc(CNC(=O)N(Cc2ccn(C)n2)[C@H]2CCNC[C@H]2F)cc1	InChI=1S/C21H30FN5O2/c1-3-12-29-18-6-4-16(5-7-18)13-24-21(28)27(15-17-9-11-26(2)25-17)20-8-10-23-14-19(20)22/h4-7,9,11,19-20,23H,3,8,10,12-15H2,1-2H3,(H,24,28)	KUGBHIAPXRVEQI-UHFFFAOYSA-N	369089	US12527775, Compound I-122	5-hydroxytryptamine receptor 2A	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369089	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369089&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90114813	402365887							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207887	CCCOc1ccc(CNC(=O)N(Cc2cc(C)n(C)n2)[C@H]2CCNC[C@H]2F)cc1	InChI=1S/C22H32FN5O2/c1-4-11-30-19-7-5-17(6-8-19)13-25-22(29)28(21-9-10-24-14-20(21)23)15-18-12-16(2)27(3)26-18/h5-8,12,20-21,24H,4,9-11,13-15H2,1-3H3,(H,25,29)	HPIYWAVCZKKHEU-UHFFFAOYSA-N	369090	US12527775, Compound I-123	5-hydroxytryptamine receptor 2A	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369090	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369090&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90115131	402365888							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207888	CN1CCC(N(Cc2ccc(F)cn2)C(=O)NCc2ccc(C3CC3)cc2)CC1	InChI=1S/C23H29FN4O/c1-27-12-10-22(11-13-27)28(16-21-9-8-20(24)15-25-21)23(29)26-14-17-2-4-18(5-3-17)19-6-7-19/h2-5,8-9,15,19,22H,6-7,10-14,16H2,1H3,(H,26,29)	XDFZHAZZPAAWGC-UHFFFAOYSA-N	369091	US12527775, Compound I-125	5-hydroxytryptamine receptor 2A	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369091	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369091&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90114465	402365889							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207889	CCCOc1ccc(CNC(=O)N(Cc2cc(C)n(C)n2)[C@@H]2CCN(C)CC23CC3)cc1	InChI=1S/C25H37N5O2/c1-5-14-32-22-8-6-20(7-9-22)16-26-24(31)30(17-21-15-19(2)29(4)27-21)23-10-13-28(3)18-25(23)11-12-25/h6-9,15,23H,5,10-14,16-18H2,1-4H3,(H,26,31)	BOKIASHIRMLMKK-UHFFFAOYSA-N	369092	US12527775, Compound I-127	5-hydroxytryptamine receptor 2A	Homo sapiens	>100								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369092	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369092&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90115063	402365890							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207890	Cc1cc(CN(C(=O)NCc2ccc(OCC(C)C)cc2)C2CCN(C)CC2)nn1CF	InChI=1S/C24H36FN5O2/c1-18(2)16-32-23-7-5-20(6-8-23)14-26-24(31)29(22-9-11-28(4)12-10-22)15-21-13-19(3)30(17-25)27-21/h5-8,13,18,22H,9-12,14-17H2,1-4H3,(H,26,31)	FCXBXAQMSYIWOD-UHFFFAOYSA-N	369093	US12527775, Compound I-128	5-hydroxytryptamine receptor 2A	Homo sapiens	 55								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369093	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369093&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90114661	402365891							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207891	COCc1ccc(CNC(=O)N(Cc2ccc(F)cn2)C2CCN(C)CC2)cc1	InChI=1S/C22H29FN4O2/c1-26-11-9-21(10-12-26)27(15-20-8-7-19(23)14-24-20)22(28)25-13-17-3-5-18(6-4-17)16-29-2/h3-8,14,21H,9-13,15-16H2,1-2H3,(H,25,28)	APBCSXZLJDLXAC-UHFFFAOYSA-N	369094	US12527775, Compound I-131	5-hydroxytryptamine receptor 2A	Homo sapiens	 55								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369094	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369094&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90114958	402365892							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207892	CC(C)COc1ccc(CNC(=O)N(Cc2ccn(C)n2)[C@H]2CCNC[C@H]2F)cc1	InChI=1S/C22H32FN5O2/c1-16(2)15-30-19-6-4-17(5-7-19)12-25-22(29)28(14-18-9-11-27(3)26-18)21-8-10-24-13-20(21)23/h4-7,9,11,16,20-21,24H,8,10,12-15H2,1-3H3,(H,25,29)	IPMREZXAURGMJI-UHFFFAOYSA-N	369095	US12527775, Compound I-132	5-hydroxytryptamine receptor 2A	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369095	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369095&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90115109	402365893							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207893	Cc1cc(CN(C(=O)NCc2ccc(OCC(C)C)cc2)[C@H]2CCNC[C@H]2F)nn1C	InChI=1S/C23H34FN5O2/c1-16(2)15-31-20-7-5-18(6-8-20)12-26-23(30)29(22-9-10-25-13-21(22)24)14-19-11-17(3)28(4)27-19/h5-8,11,16,21-22,25H,9-10,12-15H2,1-4H3,(H,26,30)	HCJPZHCBWYPSIV-UHFFFAOYSA-N	369096	US12527775, Compound I-133	5-hydroxytryptamine receptor 2A	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369096	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369096&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90114587	402365894							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207894	CC(C)COc1ccc(CNC(=O)N(Cc2cc(F)n(C)n2)C2CCN(C)CC2)cc1	InChI=1S/C23H34FN5O2/c1-17(2)16-31-21-7-5-18(6-8-21)14-25-23(30)29(20-9-11-27(3)12-10-20)15-19-13-22(24)28(4)26-19/h5-8,13,17,20H,9-12,14-16H2,1-4H3,(H,25,30)	QMSCKKGZGBFQNY-UHFFFAOYSA-N	369097	US12527775, Compound I-135	5-hydroxytryptamine receptor 2A	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369097	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369097&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90114893	402365895							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207895	CC(C)C(=O)Nc1ccc(CNC(=O)N(Cc2ccc(F)cn2)C2CCN(C)CC2)cc1	InChI=1S/C24H32FN5O2/c1-17(2)23(31)28-20-7-4-18(5-8-20)14-27-24(32)30(22-10-12-29(3)13-11-22)16-21-9-6-19(25)15-26-21/h4-9,15,17,22H,10-14,16H2,1-3H3,(H,27,32)(H,28,31)	KCQYMXHUGNIKGF-UHFFFAOYSA-N	369098	US12527775, Compound I-137	5-hydroxytryptamine receptor 2A	Homo sapiens	>100								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369098	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369098&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90115292	402365896							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207896	Cc1cc(CN(C(=O)NCc2ccc(OCC(C)C)cc2)[C@H]2CCN(C)C[C@H]2F)nn1C	InChI=1S/C24H36FN5O2/c1-17(2)16-32-21-8-6-19(7-9-21)13-26-24(31)30(14-20-12-18(3)29(5)27-20)23-10-11-28(4)15-22(23)25/h6-9,12,17,22-23H,10-11,13-16H2,1-5H3,(H,26,31)	RPIFEWACQSQQEQ-UHFFFAOYSA-N	369099	US12527775, Compound I-138	5-hydroxytryptamine receptor 2A	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369099	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369099&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			89993988	402365897							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207897	CC(C)COc1ccc(CNC(=O)N(Cc2ccn(C)c2)[C@H]2CCN(C)C[C@H]2F)cc1	InChI=1S/C24H35FN4O2/c1-18(2)17-31-21-7-5-19(6-8-21)13-26-24(30)29(15-20-9-11-27(3)14-20)23-10-12-28(4)16-22(23)25/h5-9,11,14,18,22-23H,10,12-13,15-17H2,1-4H3,(H,26,30)	GVKKJHCFUNJLAI-UHFFFAOYSA-N	369100	US12527775, Compound I-140	5-hydroxytryptamine receptor 2A	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369100	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369100&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90114845	402365898							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207898	CCCOc1ccc(CNC(=O)N(Cc2ccn(C)c2)[C@H]2CCN(C)C[C@H]2F)cc1	InChI=1S/C23H33FN4O2/c1-4-13-30-20-7-5-18(6-8-20)14-25-23(29)28(16-19-9-11-26(2)15-19)22-10-12-27(3)17-21(22)24/h5-9,11,15,21-22H,4,10,12-14,16-17H2,1-3H3,(H,25,29)	PUMOTCVLDTYGHU-UHFFFAOYSA-N	369101	US12527775, Compound I-141	5-hydroxytryptamine receptor 2A	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369101	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369101&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90114936	402365899							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207899	CC(C)COc1ccc(CNC(=O)N(Cc2cc[nH]c2)C2CCN(C)CC2)cc1	InChI=1S/C23H34N4O2/c1-18(2)17-29-22-6-4-19(5-7-22)15-25-23(28)27(16-20-8-11-24-14-20)21-9-12-26(3)13-10-21/h4-8,11,14,18,21,24H,9-10,12-13,15-17H2,1-3H3,(H,25,28)	AWVWSGLBFZHRNY-UHFFFAOYSA-N	369102	US12527775, Compound I-142	5-hydroxytryptamine receptor 2A	Homo sapiens	 55								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369102	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369102&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90114858	402365900							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207900	CC(C)COc1ccc(CNC(=O)N(Cc2cc[nH]n2)C2CCN(C)CC2)cc1	InChI=1S/C22H33N5O2/c1-17(2)16-29-21-6-4-18(5-7-21)14-23-22(28)27(15-19-8-11-24-25-19)20-9-12-26(3)13-10-20/h4-8,11,17,20H,9-10,12-16H2,1-3H3,(H,23,28)(H,24,25)	HRRFYAWWLLIVHO-UHFFFAOYSA-N	369103	US12527775, Compound I-143	5-hydroxytryptamine receptor 2A	Homo sapiens	 55								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369103	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369103&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90114475	402365901							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207901	Cc1cc(CN(C(=O)NCc2ccc(OCC(C)C)cc2)C2CCN(C)CC2)cn1C	InChI=1S/C25H38N4O2/c1-19(2)18-31-24-8-6-21(7-9-24)15-26-25(30)29(23-10-12-27(4)13-11-23)17-22-14-20(3)28(5)16-22/h6-9,14,16,19,23H,10-13,15,17-18H2,1-5H3,(H,26,30)	MZKJGGSGYAKAHN-UHFFFAOYSA-N	369104	US12527775, Compound I-144	5-hydroxytryptamine receptor 2A	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369104	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369104&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90114541	402365902							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207902	CC(C)COc1ccc(CNC(=O)N(Cc2cc(CF)n(C)n2)[C@H]2CCNC[C@H]2F)cc1	InChI=1S/C23H33F2N5O2/c1-16(2)15-32-20-6-4-17(5-7-20)12-27-23(31)30(22-8-9-26-13-21(22)25)14-18-10-19(11-24)29(3)28-18/h4-7,10,16,21-22,26H,8-9,11-15H2,1-3H3,(H,27,31)	JIQRANRWXAAFAI-UHFFFAOYSA-N	369105	US12527775, Compound I-145	5-hydroxytryptamine receptor 2A	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369105	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369105&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90114569	402365903							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207903	CC(C)COc1ccc(CNC(=O)N(Cc2cocn2)C2CCN(C)CC2)cc1	InChI=1S/C22H32N4O3/c1-17(2)14-29-21-6-4-18(5-7-21)12-23-22(27)26(13-19-15-28-16-24-19)20-8-10-25(3)11-9-20/h4-7,15-17,20H,8-14H2,1-3H3,(H,23,27)	AGKSXEOEBBFAEM-UHFFFAOYSA-N	369106	US12527775, Compound I-148	5-hydroxytryptamine receptor 2A	Homo sapiens	 55								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77		aid1799580	US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369106	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=687&target=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369106&enzyme=5-hydroxytryptamine+receptor+2A&column=ki&startPg=0&Increment=50&submit=Search			90114801	402365904							1	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV	9LLB,9LLA,9LL9,9LL8,9LL7,9ASA,9AS9,9AS8,9AS7,9AS6,9AS5,9AS4,9AS3,9AS2,9AS1,9AS0,9ARZ,9ARY,9ARX,6WHA,8V6U,8UWL,7RAN	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	P28223	B2RAC5 B4DZ79 F5GWE8 Q5T8C0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207904	CC(C)COc1ccc(CNC(=O)N(Cc2ccc(Cl)cn2)C2CCN(C)CC2)cc1	InChI=1S/C24H33ClN4O2/c1-18(2)17-31-23-8-4-19(5-9-23)14-27-24(30)29(22-10-12-28(3)13-11-22)16-21-7-6-20(25)15-26-21/h4-9,15,18,22H,10-14,16-17H2,1-3H3,(H,27,30)	YEDRUSULEMDABE-UHFFFAOYSA-N	368957	US12527775, Compound I-009	5-hydroxytryptamine receptor 2C	Homo sapiens	 7.92								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368957	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368957&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90115293	402365756							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207905	CC(C)COc1ccc(CNC(=O)N(Cc2ccn(C)n2)C2CCN(C)CC2)cc1	InChI=1S/C23H35N5O2/c1-18(2)17-30-22-7-5-19(6-8-22)15-24-23(29)28(16-20-9-14-27(4)25-20)21-10-12-26(3)13-11-21/h5-9,14,18,21H,10-13,15-17H2,1-4H3,(H,24,29)	DYVUYEIPCXXJPJ-UHFFFAOYSA-N	368958	US12527775, Compound I-021	5-hydroxytryptamine receptor 2C	Homo sapiens	 50.7								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368958	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368958&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90115129	402365757							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207906	CC(C)COc1ccc(CNC(=O)N(Cc2cc3ccccc3cn2)C2CCN(C)CC2)cc1	InChI=1S/C28H36N4O2/c1-21(2)20-34-27-10-8-22(9-11-27)17-30-28(33)32(26-12-14-31(3)15-13-26)19-25-16-23-6-4-5-7-24(23)18-29-25/h4-11,16,18,21,26H,12-15,17,19-20H2,1-3H3,(H,30,33)	DMEZBDVKBCXCAW-UHFFFAOYSA-N	368959	US12527775, Compound I-037	5-hydroxytryptamine receptor 2C	Homo sapiens	 28.2								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368959	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368959&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90114833	402365758							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207907	CC(C)COc1ccc(COC(=O)N(Cc2ccc(F)cn2)C2CCN(C)CC2)cc1	InChI=1S/C24H32FN3O3/c1-18(2)16-30-23-8-4-19(5-9-23)17-31-24(29)28(22-10-12-27(3)13-11-22)15-21-7-6-20(25)14-26-21/h4-9,14,18,22H,10-13,15-17H2,1-3H3	JOHIZHSVLNZEFM-UHFFFAOYSA-N	368960	US12527775, Compound I-042	5-hydroxytryptamine receptor 2C	Homo sapiens	 2.31								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368960	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368960&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90114882	402365759							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207908	COc1ccc(CNC(=O)N(Cc2ccc(F)cn2)C2CCN(C)CC2)cc1	InChI=1S/C21H27FN4O2/c1-25-11-9-19(10-12-25)26(15-18-6-5-17(22)14-23-18)21(27)24-13-16-3-7-20(28-2)8-4-16/h3-8,14,19H,9-13,15H2,1-2H3,(H,24,27)	PUALGYQQGJBFFN-UHFFFAOYSA-N	368961	US12527775, Compound I-043	5-hydroxytryptamine receptor 2C	Homo sapiens	 55.7								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368961	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368961&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90114593	402365760							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207909	CC(C)COc1ccc(CC(=O)N(Cc2ccc(F)cn2)C2CCN(C)CC2)cc1	InChI=1S/C24H32FN3O2/c1-18(2)17-30-23-8-4-19(5-9-23)14-24(29)28(22-10-12-27(3)13-11-22)16-21-7-6-20(25)15-26-21/h4-9,15,18,22H,10-14,16-17H2,1-3H3	QVKDJGZGOMKBSU-UHFFFAOYSA-N	368962	US12527775, Compound I-068	5-hydroxytryptamine receptor 2C	Homo sapiens	 49.9								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368962	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368962&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90114293	402365761							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207910	CC(C)COc1ccc(CNC(=O)N(Cc2ccc(F)c3ccoc23)C2CCN(C)CC2)cc1	InChI=1S/C27H34FN3O3/c1-19(2)18-34-23-7-4-20(5-8-23)16-29-27(32)31(22-10-13-30(3)14-11-22)17-21-6-9-25(28)24-12-15-33-26(21)24/h4-9,12,15,19,22H,10-11,13-14,16-18H2,1-3H3,(H,29,32)	VORIIPRUWIHSRU-UHFFFAOYSA-N	368963	US12527775, Compound I-071	5-hydroxytryptamine receptor 2C	Homo sapiens	 60.7								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368963	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368963&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90114821	402365762							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207911	CC(C)COc1ccc(CNC(=O)N(Cc2cc3c(cn2)OCCO3)C2CCN(C)CC2)cc1	InChI=1S/C26H36N4O4/c1-19(2)18-34-23-6-4-20(5-7-23)15-28-26(31)30(22-8-10-29(3)11-9-22)17-21-14-24-25(16-27-21)33-13-12-32-24/h4-7,14,16,19,22H,8-13,15,17-18H2,1-3H3,(H,28,31)	ZKMKNANNWRLODJ-UHFFFAOYSA-N	368964	US12527775, Compound I-072	5-hydroxytryptamine receptor 2C	Homo sapiens	 617								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368964	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368964&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90114960	402365763							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207912	CN1CCC(N(Cc2ccc(F)cn2)C(=O)NCc2cccc(O)c2)CC1	InChI=1S/C20H25FN4O2/c1-24-9-7-18(8-10-24)25(14-17-6-5-16(21)13-22-17)20(27)23-12-15-3-2-4-19(26)11-15/h2-6,11,13,18,26H,7-10,12,14H2,1H3,(H,23,27)	WBOIGIZGFANRAP-UHFFFAOYSA-N	368965	US12527775, Compound I-075	5-hydroxytryptamine receptor 2C	Homo sapiens	 1310								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368965	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368965&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90115033	402365764							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207913	CN1CCC(N(Cc2ccc(F)cn2)C(=O)NCc2ccccc2O)CC1	InChI=1S/C20H25FN4O2/c1-24-10-8-18(9-11-24)25(14-17-7-6-16(21)13-22-17)20(27)23-12-15-4-2-3-5-19(15)26/h2-7,13,18,26H,8-12,14H2,1H3,(H,23,27)	FCMOKMRAVXNDRP-UHFFFAOYSA-N	368966	US12527775, Compound I-076	5-hydroxytryptamine receptor 2C	Homo sapiens	 263								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368966	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368966&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90115325	402365765							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207914	CN1CCC(N(Cc2ccc(F)cn2)C(=O)NCc2ccc(Br)cc2)CC1	InChI=1S/C20H24BrFN4O/c1-25-10-8-19(9-11-25)26(14-18-7-6-17(22)13-23-18)20(27)24-12-15-2-4-16(21)5-3-15/h2-7,13,19H,8-12,14H2,1H3,(H,24,27)	ADIMPFIRIIXWIL-UHFFFAOYSA-N	368967	US12527775, Compound I-082	5-hydroxytryptamine receptor 2C	Homo sapiens	 28.8								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368967	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368967&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90114782	402365766							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207915	CN1CCC(N(Cc2ccc(F)cn2)C(=O)NCc2ccc(Cl)cc2)CC1	InChI=1S/C20H24ClFN4O/c1-25-10-8-19(9-11-25)26(14-18-7-6-17(22)13-23-18)20(27)24-12-15-2-4-16(21)5-3-15/h2-7,13,19H,8-12,14H2,1H3,(H,24,27)	DUBASJUZOVOHOD-UHFFFAOYSA-N	368968	US12527775, Compound I-084	5-hydroxytryptamine receptor 2C	Homo sapiens	 65.2								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368968	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368968&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90114634	402365767							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207916	CC(C)COc1ccc(CNC(=O)N(Cc2ccc(F)cn2)[C@@H]2CCN(C)C[C@@H]2F)cc1	InChI=1S/C24H32F2N4O2/c1-17(2)16-32-21-8-4-18(5-9-21)12-28-24(31)30(14-20-7-6-19(25)13-27-20)23-10-11-29(3)15-22(23)26/h4-9,13,17,22-23H,10-12,14-16H2,1-3H3,(H,28,31)	RELRUDTWGGXBJF-UHFFFAOYSA-N	368969	US12527775, Compound I-085	5-hydroxytryptamine receptor 2C	Homo sapiens	 96.2								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368969	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368969&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90115474	402365768							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207917	CC(C)COc1ccc(CNC(=O)N(Cc2ccc(F)cn2)[C@H]2CCN(C)C[C@@H]2O)cc1	InChI=1S/C24H33FN4O3/c1-17(2)16-32-21-8-4-18(5-9-21)12-27-24(31)29(14-20-7-6-19(25)13-26-20)22-10-11-28(3)15-23(22)30/h4-9,13,17,22-23,30H,10-12,14-16H2,1-3H3,(H,27,31)	OTQNKXUNJMNGOX-UHFFFAOYSA-N	368970	US12527775, Compound I-088	5-hydroxytryptamine receptor 2C	Homo sapiens	 134								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368970	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368970&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90114809	402365769							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207918	CCCOc1ccc(CNC(=O)N(Cc2ccn(C)n2)[C@H]2CCN(C)CC23CC3)cc1	InChI=1S/C24H35N5O2/c1-4-15-31-21-7-5-19(6-8-21)16-25-23(30)29(17-20-9-14-28(3)26-20)22-10-13-27(2)18-24(22)11-12-24/h5-9,14,22H,4,10-13,15-18H2,1-3H3,(H,25,30)	HOVLTWZHAUDSGN-UHFFFAOYSA-N	50645461	CHEMBL5592950::US12527775, Compound I-102	5-hydroxytryptamine receptor 2C	Homo sapiens	 4.01								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50645461	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50645461&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			169811671	519660863							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207919	CCc1ccc(CNC(=O)N(Cc2ccc(F)cn2)C2CCN(C)CC2)cc1	InChI=1S/C22H29FN4O/c1-3-17-4-6-18(7-5-17)14-25-22(28)27(21-10-12-26(2)13-11-21)16-20-9-8-19(23)15-24-20/h4-9,15,21H,3,10-14,16H2,1-2H3,(H,25,28)	QWNGGMAFPJOHPR-UHFFFAOYSA-N	368973	US12527775, Compound I-116	5-hydroxytryptamine receptor 2C	Homo sapiens	 12.2								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368973	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368973&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90114638	402365772							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207920	CC(C)COc1ccc(CNC(=O)N(Cc2ccn(C)c2)[C@H]2CCNC[C@H]2F)cc1	InChI=1S/C23H33FN4O2/c1-17(2)16-30-20-6-4-18(5-7-20)12-26-23(29)28(15-19-9-11-27(3)14-19)22-8-10-25-13-21(22)24/h4-7,9,11,14,17,21-22,25H,8,10,12-13,15-16H2,1-3H3,(H,26,29)	WXBLNXYIJLJMGY-UHFFFAOYSA-N	368974	US12527775, Compound I-124	5-hydroxytryptamine receptor 2C	Homo sapiens	 2.22								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368974	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368974&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90115247	402365773							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207921	CCCOc1ccc(CNC(=O)N(Cc2cc(C)n(C)n2)[C@H]2CCN(C)CC23CC3)cc1	InChI=1S/C25H37N5O2/c1-5-14-32-22-8-6-20(7-9-22)16-26-24(31)30(17-21-15-19(2)29(4)27-21)23-10-13-28(3)18-25(23)11-12-25/h6-9,15,23H,5,10-14,16-18H2,1-4H3,(H,26,31)	BOKIASHIRMLMKK-UHFFFAOYSA-N	368975	US12527775, Compound I-126	5-hydroxytryptamine receptor 2C	Homo sapiens	 1.09								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368975	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368975&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90114891	402365774							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207922	CC(C)CNc1ccc(CNC(=O)N(Cc2ccc(F)cn2)[C@H]2CCNC[C@H]2F)cc1	InChI=1S/C23H31F2N5O/c1-16(2)11-27-19-6-3-17(4-7-19)12-29-23(31)30(22-9-10-26-14-21(22)25)15-20-8-5-18(24)13-28-20/h3-8,13,16,21-22,26-27H,9-12,14-15H2,1-2H3,(H,29,31)	JOONQQPCPNINAA-UHFFFAOYSA-N	368976	US12527775, Compound I-129	5-hydroxytryptamine receptor 2C	Homo sapiens	 1.51								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368976	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368976&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90113968	402365775							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207923	COCc1ccc(CNC(=O)N(Cc2ccc(C)cn2)C2CCN(C)CC2)cc1	InChI=1S/C23H32N4O2/c1-18-4-9-21(24-14-18)16-27(22-10-12-26(2)13-11-22)23(28)25-15-19-5-7-20(8-6-19)17-29-3/h4-9,14,22H,10-13,15-17H2,1-3H3,(H,25,28)	FORWHHUOSDGSMH-UHFFFAOYSA-N	368977	US12527775, Compound I-130	5-hydroxytryptamine receptor 2C	Homo sapiens	 348								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368977	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368977&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90115078	402365776							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207924	CCCOc1ccc(CNC(=O)N(Cc2ccn(C)c2)[C@H]2CCNC[C@H]2F)cc1	InChI=1S/C22H31FN4O2/c1-3-12-29-19-6-4-17(5-7-19)13-25-22(28)27(16-18-9-11-26(2)15-18)21-8-10-24-14-20(21)23/h4-7,9,11,15,20-21,24H,3,8,10,12-14,16H2,1-2H3,(H,25,28)	KGNCORAPCMJZMR-UHFFFAOYSA-N	368978	US12527775, Compound I-134	5-hydroxytryptamine receptor 2C	Homo sapiens	 3.20								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368978	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368978&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90115344	402365777							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207925	CC(C)COc1ccc(CNC(=O)N(Cc2ccc(F)cn2)C2CCN(C)C3(CC3)C2)cc1	InChI=1S/C26H35FN4O2/c1-19(2)18-33-24-8-4-20(5-9-24)15-29-25(32)31(17-22-7-6-21(27)16-28-22)23-10-13-30(3)26(14-23)11-12-26/h4-9,16,19,23H,10-15,17-18H2,1-3H3,(H,29,32)	MGTJJEWROCDVOA-UHFFFAOYSA-N	368979	US12527775, Compound I-136	5-hydroxytryptamine receptor 2C	Homo sapiens	 148								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368979	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368979&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90114674	402365778							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207926	CCCOc1ccc(CNC(=O)N(Cc2cc(C)n(C)n2)[C@H]2CCN(C)C[C@H]2F)cc1	InChI=1S/C23H34FN5O2/c1-5-12-31-20-8-6-18(7-9-20)14-25-23(30)29(15-19-13-17(2)28(4)26-19)22-10-11-27(3)16-21(22)24/h6-9,13,21-22H,5,10-12,14-16H2,1-4H3,(H,25,30)	MBTSTFUSFZSMQV-UHFFFAOYSA-N	368980	US12527775, Compound I-139	5-hydroxytryptamine receptor 2C	Homo sapiens	 11.1								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368980	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368980&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90114562	402365779							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207927	CC(C)COc1ccc(CNC(=O)N(Cc2cc(CF)n(C)n2)[C@H]2CCN(C)C[C@H]2F)cc1	InChI=1S/C24H35F2N5O2/c1-17(2)16-33-21-7-5-18(6-8-21)13-27-24(32)31(23-9-10-29(3)15-22(23)26)14-19-11-20(12-25)30(4)28-19/h5-8,11,17,22-23H,9-10,12-16H2,1-4H3,(H,27,32)	UEOITUGSFHEHMM-UHFFFAOYSA-N	368981	US12527775, Compound I-146	5-hydroxytryptamine receptor 2C	Homo sapiens	 4.96								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368981	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368981&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90114837	402365780							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207928	CC(C)CN(C)c1ccc(CNC(=O)N(Cc2ccc(F)cn2)[C@H]2CCN(C)C[C@H]2F)cc1	InChI=1S/C25H35F2N5O/c1-18(2)15-31(4)22-9-5-19(6-10-22)13-29-25(33)32(16-21-8-7-20(26)14-28-21)24-11-12-30(3)17-23(24)27/h5-10,14,18,23-24H,11-13,15-17H2,1-4H3,(H,29,33)	OZWUSGMYHJFGFC-UHFFFAOYSA-N	368982	US12527775, Compound I-147	5-hydroxytryptamine receptor 2C	Homo sapiens	 2.12								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368982	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368982&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90134911	402365781							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207929	CC(C)COc1ccc(CNC(=O)N(Cc2ccccn2)C2CCN(C)CC2)cc1	InChI=1S/C24H34N4O2/c1-19(2)18-30-23-9-7-20(8-10-23)16-26-24(29)28(17-21-6-4-5-13-25-21)22-11-14-27(3)15-12-22/h4-10,13,19,22H,11-12,14-18H2,1-3H3,(H,26,29)	UXTPWMGDBKRHQC-UHFFFAOYSA-N	368983	US12527775, Compound I-001	5-hydroxytryptamine receptor 2C	Homo sapiens	 55								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368983	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368983&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90114499	402365782							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207930	CC(C)COc1ccc(CNC(=O)N(Cc2cccnc2)C2CCN(C)CC2)cc1	InChI=1S/C24H34N4O2/c1-19(2)18-30-23-8-6-20(7-9-23)16-26-24(29)28(17-21-5-4-12-25-15-21)22-10-13-27(3)14-11-22/h4-9,12,15,19,22H,10-11,13-14,16-18H2,1-3H3,(H,26,29)	VRNUNIGKMGDJJK-UHFFFAOYSA-N	368984	US12527775, Compound I-002	5-hydroxytryptamine receptor 2C	Homo sapiens	>100								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368984	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368984&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90114619	402365783							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207931	CC(C)COc1ccc(CNC(=O)N(Cc2ccncc2)C2CCN(C)CC2)cc1	InChI=1S/C24H34N4O2/c1-19(2)18-30-23-6-4-20(5-7-23)16-26-24(29)28(17-21-8-12-25-13-9-21)22-10-14-27(3)15-11-22/h4-9,12-13,19,22H,10-11,14-18H2,1-3H3,(H,26,29)	LVRLTRCYPPEDBZ-UHFFFAOYSA-N	368985	US12527775, Compound I-003	5-hydroxytryptamine receptor 2C	Homo sapiens	>100								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368985	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368985&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90115175	402365784							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207932	CC(C)COc1ccc(CNC(=O)N(Cc2ncccn2)C2CCN(C)CC2)cc1	InChI=1S/C23H33N5O2/c1-18(2)17-30-21-7-5-19(6-8-21)15-26-23(29)28(16-22-24-11-4-12-25-22)20-9-13-27(3)14-10-20/h4-8,11-12,18,20H,9-10,13-17H2,1-3H3,(H,26,29)	UTLOXSBDULDVCZ-UHFFFAOYSA-N	368986	US12527775, Compound I-004	5-hydroxytryptamine receptor 2C	Homo sapiens	>100								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368986	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368986&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90114605	402365785							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207933	CC(C)COc1ccc(CNC(=O)N(Cc2cccnn2)C2CCN(C)CC2)cc1	InChI=1S/C23H33N5O2/c1-18(2)17-30-22-8-6-19(7-9-22)15-24-23(29)28(16-20-5-4-12-25-26-20)21-10-13-27(3)14-11-21/h4-9,12,18,21H,10-11,13-17H2,1-3H3,(H,24,29)	BSFQDIYLWRZEAM-UHFFFAOYSA-N	368987	US12527775, Compound I-005	5-hydroxytryptamine receptor 2C	Homo sapiens	>100								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368987	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368987&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90114842	402365786							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207934	CC(C)COc1ccc(CNC(=O)N(Cc2cnccn2)C2CCN(C)CC2)cc1	InChI=1S/C23H33N5O2/c1-18(2)17-30-22-6-4-19(5-7-22)14-26-23(29)28(16-20-15-24-10-11-25-20)21-8-12-27(3)13-9-21/h4-7,10-11,15,18,21H,8-9,12-14,16-17H2,1-3H3,(H,26,29)	WXMBSNFSLZTCEU-UHFFFAOYSA-N	368988	US12527775, Compound I-006	5-hydroxytryptamine receptor 2C	Homo sapiens	>100								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368988	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368988&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90114288	402365787							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207935	CC(C)COc1ccc(CNC(=O)N(Cc2cncnc2)C2CCN(C)CC2)cc1	InChI=1S/C23H33N5O2/c1-18(2)16-30-22-6-4-19(5-7-22)14-26-23(29)28(15-20-12-24-17-25-13-20)21-8-10-27(3)11-9-21/h4-7,12-13,17-18,21H,8-11,14-16H2,1-3H3,(H,26,29)	KZAAESQVSREAQR-UHFFFAOYSA-N	368989	US12527775, Compound I-007	5-hydroxytryptamine receptor 2C	Homo sapiens	>100								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368989	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368989&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90114402	402365788							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207936	CC(C)COc1ccc(CNC(=O)N(Cc2ccc(F)cn2)C2CCN(C)CC2)cc1	InChI=1S/C24H33FN4O2/c1-18(2)17-31-23-8-4-19(5-9-23)14-27-24(30)29(22-10-12-28(3)13-11-22)16-21-7-6-20(25)15-26-21/h4-9,15,18,22H,10-14,16-17H2,1-3H3,(H,27,30)	MLLAVJGUUBZDGD-UHFFFAOYSA-N	50596718	CHEMBL5184703::US20230348421, Compound 1::US12527775, Compound I-008	5-hydroxytryptamine receptor 2C	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50596718	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50596718&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			168283780	482607570							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207937	COc1ccc(CN(C(=O)NCc2ccc(OCC(C)C)cc2)C2CCN(C)CC2)nc1	InChI=1S/C25H36N4O3/c1-19(2)18-32-23-8-5-20(6-9-23)15-27-25(30)29(22-11-13-28(3)14-12-22)17-21-7-10-24(31-4)16-26-21/h5-10,16,19,22H,11-15,17-18H2,1-4H3,(H,27,30)	BKTVUNBWQXVJSW-UHFFFAOYSA-N	368991	US12527775, Compound I-010	5-hydroxytryptamine receptor 2C	Homo sapiens	 55								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368991	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368991&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90114393	402365790							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207938	N#Cc1ccc(CN(C(=O)NCc2ccc(OCC(C)C)cc2)C2CCN(C)CC2)nc1	InChI=1S/C25H33N5O2/c1-19(2)18-32-24-8-5-20(6-9-24)15-28-25(31)30(23-10-12-29(3)13-11-23)17-22-7-4-21(14-26)16-27-22/h4-9,16,19,23H,10-13,15,17-18H2,1-3H3,(H,28,31)	XBAOKRXXQFILIC-UHFFFAOYSA-N	368992	US12527775, Compound I-011	5-hydroxytryptamine receptor 2C	Homo sapiens	>100								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368992	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368992&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90114814	402365791							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207939	CC(C)COc1ccc(CNC(=O)N(Cc2ccc(C(F)(F)F)cn2)C2CCN(C)CC2)cc1	InChI=1S/C25H33F3N4O2/c1-18(2)17-34-23-8-4-19(5-9-23)14-30-24(33)32(22-10-12-31(3)13-11-22)16-21-7-6-20(15-29-21)25(26,27)28/h4-9,15,18,22H,10-14,16-17H2,1-3H3,(H,30,33)	HVWRVSOCJOCWJU-UHFFFAOYSA-N	368993	US12527775, Compound I-012	5-hydroxytryptamine receptor 2C	Homo sapiens	 55								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368993	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368993&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			86718040	402365792							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207940	Cc1ccc(CN(C(=O)NCc2ccc(OCC(C)C)cc2)C2CCN(C)CC2)nc1	InChI=1S/C25H36N4O2/c1-19(2)18-31-24-9-6-21(7-10-24)16-27-25(30)29(23-11-13-28(4)14-12-23)17-22-8-5-20(3)15-26-22/h5-10,15,19,23H,11-14,16-18H2,1-4H3,(H,27,30)	GJGJPQXDSCFRCH-UHFFFAOYSA-N	368995	US12527775, Compound I-013	5-hydroxytryptamine receptor 2C	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368995	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368995&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90115179	402365793							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207941	CC(C)COc1ccc(CNC(=O)N(Cc2ncc(F)cc2F)C2CCN(C)CC2)cc1	InChI=1S/C24H32F2N4O2/c1-17(2)16-32-21-6-4-18(5-7-21)13-28-24(31)30(20-8-10-29(3)11-9-20)15-23-22(26)12-19(25)14-27-23/h4-7,12,14,17,20H,8-11,13,15-16H2,1-3H3,(H,28,31)	CXDAWYJEMGTVJX-UHFFFAOYSA-N	50596720	CHEMBL5200635::US12527775, Compound I-014	5-hydroxytryptamine receptor 2C	Homo sapiens	 55								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50596720	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50596720&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			168292138	482607572							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207942	CC(C)COc1ccc(CNC(=O)N(Cc2ncc(F)cc2Cl)C2CCN(C)CC2)cc1	InChI=1S/C24H32ClFN4O2/c1-17(2)16-32-21-6-4-18(5-7-21)13-28-24(31)30(20-8-10-29(3)11-9-20)15-23-22(25)12-19(26)14-27-23/h4-7,12,14,17,20H,8-11,13,15-16H2,1-3H3,(H,28,31)	BKQXAIWOMSDZGY-UHFFFAOYSA-N	368997	US12527775, Compound I-015	5-hydroxytryptamine receptor 2C	Homo sapiens	>100								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368997	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368997&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90114489	402365795							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207943	CC(C)COc1ccc(CNC(=O)N(Cc2ncccc2F)C2CCN(C)CC2)cc1	InChI=1S/C24H33FN4O2/c1-18(2)17-31-21-8-6-19(7-9-21)15-27-24(30)29(20-10-13-28(3)14-11-20)16-23-22(25)5-4-12-26-23/h4-9,12,18,20H,10-11,13-17H2,1-3H3,(H,27,30)	ZAMMVJDZUPUELZ-UHFFFAOYSA-N	368998	US12527775, Compound I-016	5-hydroxytryptamine receptor 2C	Homo sapiens	>100								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368998	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368998&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90114309	402365796							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207944	CC(C)COc1ccc(CNC(=O)N(Cc2cc(F)ccn2)C2CCN(C)CC2)cc1	InChI=1S/C24H33FN4O2/c1-18(2)17-31-23-6-4-19(5-7-23)15-27-24(30)29(22-9-12-28(3)13-10-22)16-21-14-20(25)8-11-26-21/h4-8,11,14,18,22H,9-10,12-13,15-17H2,1-3H3,(H,27,30)	YHABPOZFDXRKMW-UHFFFAOYSA-N	368999	US12527775, Compound I-017	5-hydroxytryptamine receptor 2C	Homo sapiens	>100								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368999	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368999&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90114768	402365797							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207945	CC(C)COc1ccc(CNC(=O)N(Cc2cccc(F)n2)C2CCN(C)CC2)cc1	InChI=1S/C24H33FN4O2/c1-18(2)17-31-22-9-7-19(8-10-22)15-26-24(30)29(21-11-13-28(3)14-12-21)16-20-5-4-6-23(25)27-20/h4-10,18,21H,11-17H2,1-3H3,(H,26,30)	ZSMHROITERWGGD-UHFFFAOYSA-N	369000	US12527775, Compound I-018	5-hydroxytryptamine receptor 2C	Homo sapiens	>100								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369000	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369000&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90114017	402365798							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207946	CC(C)COc1ccc(CNC(=O)N(Cc2ccc(F)nc2)C2CCN(C)CC2)cc1	InChI=1S/C24H33FN4O2/c1-18(2)17-31-22-7-4-19(5-8-22)14-27-24(30)29(21-10-12-28(3)13-11-21)16-20-6-9-23(25)26-15-20/h4-9,15,18,21H,10-14,16-17H2,1-3H3,(H,27,30)	NLNJPUVDBXPERZ-UHFFFAOYSA-N	50596750	CHEMBL5179185::US12527775, Compound I-019	5-hydroxytryptamine receptor 2C	Homo sapiens	>100								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50596750	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50596750&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			168274667	482607602							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207947	CC(C)COc1ccc(CNC(=O)N(Cc2ncc(F)cn2)C2CCN(C)CC2)cc1	InChI=1S/C23H32FN5O2/c1-17(2)16-31-21-6-4-18(5-7-21)12-27-23(30)29(20-8-10-28(3)11-9-20)15-22-25-13-19(24)14-26-22/h4-7,13-14,17,20H,8-12,15-16H2,1-3H3,(H,27,30)	KBFQXTVCSCMAII-UHFFFAOYSA-N	631390	US20230348421, Compound 13::US12527775, Compound I-020	5-hydroxytryptamine receptor 2C	Homo sapiens	 55								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=631390	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=631390&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			169490282	485658868							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207948	CC(C)COc1ccc(CNC(=O)N(Cc2cnn(C)c2)C2CCN(C)CC2)cc1	InChI=1S/C23H35N5O2/c1-18(2)17-30-22-7-5-19(6-8-22)13-24-23(29)28(16-20-14-25-27(4)15-20)21-9-11-26(3)12-10-21/h5-8,14-15,18,21H,9-13,16-17H2,1-4H3,(H,24,29)	WQZCXKPBFILXFJ-UHFFFAOYSA-N	369003	US12527775, Compound I-022	5-hydroxytryptamine receptor 2C	Homo sapiens	>100								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369003	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369003&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			89993976	402365801							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207949	CC(C)COc1ccc(CNC(=O)N(Cc2ccnn2C)C2CCN(C)CC2)cc1	InChI=1S/C23H35N5O2/c1-18(2)17-30-22-7-5-19(6-8-22)15-24-23(29)28(16-21-9-12-25-27(21)4)20-10-13-26(3)14-11-20/h5-9,12,18,20H,10-11,13-17H2,1-4H3,(H,24,29)	LXTUMJFQUUGWQL-UHFFFAOYSA-N	369004	US12527775, Compound I-023	5-hydroxytryptamine receptor 2C	Homo sapiens	>100								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369004	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369004&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90115409	402365802							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207950	CC(C)COc1ccc(CNC(=O)N(Cc2nccn2C)C2CCN(C)CC2)cc1	InChI=1S/C23H35N5O2/c1-18(2)17-30-21-7-5-19(6-8-21)15-25-23(29)28(16-22-24-11-14-27(22)4)20-9-12-26(3)13-10-20/h5-8,11,14,18,20H,9-10,12-13,15-17H2,1-4H3,(H,25,29)	BUHFKUPHTQNPNM-UHFFFAOYSA-N	369005	US12527775, Compound I-024	5-hydroxytryptamine receptor 2C	Homo sapiens	>100								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369005	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369005&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90114955	402365803							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207951	CC(C)COc1ccc(CNC(=O)N(Cc2cn(C)cn2)C2CCN(C)CC2)cc1	InChI=1S/C23H35N5O2/c1-18(2)16-30-22-7-5-19(6-8-22)13-24-23(29)28(15-20-14-27(4)17-25-20)21-9-11-26(3)12-10-21/h5-8,14,17-18,21H,9-13,15-16H2,1-4H3,(H,24,29)	UIDHOJOSTPSITG-UHFFFAOYSA-N	369006	US12527775, Compound I-025	5-hydroxytryptamine receptor 2C	Homo sapiens	 55								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369006	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369006&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90114720	402365804							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207952	CC(C)COc1ccc(CNC(=O)N(Cc2cc[nH]n2)C2CCN(C)CC2)cc1	InChI=1S/C22H33N5O2/c1-17(2)16-29-21-6-4-18(5-7-21)14-23-22(28)27(15-19-8-11-24-25-19)20-9-12-26(3)13-10-20/h4-8,11,17,20H,9-10,12-16H2,1-3H3,(H,23,28)(H,24,25)	HRRFYAWWLLIVHO-UHFFFAOYSA-N	369007	US12527775, Compound I-026	5-hydroxytryptamine receptor 2C	Homo sapiens	>100								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369007	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369007&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90115339	402365805							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207953	CC(C)COc1ccc(CNC(=O)N(Cc2ccn(C)c2)C2CCN(C)CC2)cc1	InChI=1S/C24H36N4O2/c1-19(2)18-30-23-7-5-20(6-8-23)15-25-24(29)28(17-21-9-12-27(4)16-21)22-10-13-26(3)14-11-22/h5-9,12,16,19,22H,10-11,13-15,17-18H2,1-4H3,(H,25,29)	RTKOEICOSPJBQY-UHFFFAOYSA-N	369008	US12527775, Compound I-027	5-hydroxytryptamine receptor 2C	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369008	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369008&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90114701	402365806							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207954	CC(C)COc1ccc(CNC(=O)N(Cc2cccn2C)C2CCN(C)CC2)cc1	InChI=1S/C24H36N4O2/c1-19(2)18-30-23-9-7-20(8-10-23)16-25-24(29)28(17-22-6-5-13-27(22)4)21-11-14-26(3)15-12-21/h5-10,13,19,21H,11-12,14-18H2,1-4H3,(H,25,29)	JXBZJUKLAIEHHN-UHFFFAOYSA-N	369009	US12527775, Compound I-028	5-hydroxytryptamine receptor 2C	Homo sapiens	>100								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369009	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369009&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90114237	402365807							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207955	CC(C)COc1ccc(CNC(=O)N(Cc2cccs2)C2CCN(C)CC2)cc1	InChI=1S/C23H33N3O2S/c1-18(2)17-28-21-8-6-19(7-9-21)15-24-23(27)26(16-22-5-4-14-29-22)20-10-12-25(3)13-11-20/h4-9,14,18,20H,10-13,15-17H2,1-3H3,(H,24,27)	BHSGHONNOZWKFB-UHFFFAOYSA-N	369010	US12527775, Compound I-029	5-hydroxytryptamine receptor 2C	Homo sapiens	 55								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369010	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369010&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90115353	402365808							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207956	Cc1ccc(CN(C(=O)NCc2ccc(OCC(C)C)cc2)C2CCN(C)CC2)s1	InChI=1S/C24H35N3O2S/c1-18(2)17-29-22-8-6-20(7-9-22)15-25-24(28)27(16-23-10-5-19(3)30-23)21-11-13-26(4)14-12-21/h5-10,18,21H,11-17H2,1-4H3,(H,25,28)	QEIHFEYWIJXBRN-UHFFFAOYSA-N	369011	US12527775, Compound I-030	5-hydroxytryptamine receptor 2C	Homo sapiens	 55								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369011	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369011&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90115359	402365809							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207957	Cc1csc(CN(C(=O)NCc2ccc(OCC(C)C)cc2)C2CCN(C)CC2)c1	InChI=1S/C24H35N3O2S/c1-18(2)16-29-22-7-5-20(6-8-22)14-25-24(28)27(15-23-13-19(3)17-30-23)21-9-11-26(4)12-10-21/h5-8,13,17-18,21H,9-12,14-16H2,1-4H3,(H,25,28)	PIHPFLATLIGUAP-UHFFFAOYSA-N	369012	US12527775, Compound I-031	5-hydroxytryptamine receptor 2C	Homo sapiens	 55								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369012	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369012&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90001680	402365810							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207958	CC(C)COc1ccc(CNC(=O)N(Cc2nccs2)C2CCN(C)CC2)cc1	InChI=1S/C22H32N4O2S/c1-17(2)16-28-20-6-4-18(5-7-20)14-24-22(27)26(15-21-23-10-13-29-21)19-8-11-25(3)12-9-19/h4-7,10,13,17,19H,8-9,11-12,14-16H2,1-3H3,(H,24,27)	VSMFWKPFNCUDAY-UHFFFAOYSA-N	369013	US12527775, Compound I-032	5-hydroxytryptamine receptor 2C	Homo sapiens	>100								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369013	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369013&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90001230	402365811							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207959	CC(C)COc1ccc(CNC(=O)N(Cc2ncco2)C2CCN(C)CC2)cc1	InChI=1S/C22H32N4O3/c1-17(2)16-29-20-6-4-18(5-7-20)14-24-22(27)26(15-21-23-10-13-28-21)19-8-11-25(3)12-9-19/h4-7,10,13,17,19H,8-9,11-12,14-16H2,1-3H3,(H,24,27)	KCVZHQVUDBZJAP-UHFFFAOYSA-N	369014	US12527775, Compound I-033	5-hydroxytryptamine receptor 2C	Homo sapiens	>100								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369014	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369014&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90114975	402365812							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207960	CC(C)COc1ccc(CNC(=O)N(Cc2ccns2)C2CCN(C)CC2)cc1	InChI=1S/C22H32N4O2S/c1-17(2)16-28-20-6-4-18(5-7-20)14-23-22(27)26(15-21-8-11-24-29-21)19-9-12-25(3)13-10-19/h4-8,11,17,19H,9-10,12-16H2,1-3H3,(H,23,27)	ISNWBTSZIYTFLG-UHFFFAOYSA-N	369015	US12527775, Compound I-034	5-hydroxytryptamine receptor 2C	Homo sapiens	>100								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369015	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369015&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90001178	402365813							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207961	Cc1cc(CN(C(=O)NCc2ccc(OCC(C)C)cc2)C2CCN(C)CC2)no1	InChI=1S/C23H34N4O3/c1-17(2)16-29-22-7-5-19(6-8-22)14-24-23(28)27(15-20-13-18(3)30-25-20)21-9-11-26(4)12-10-21/h5-8,13,17,21H,9-12,14-16H2,1-4H3,(H,24,28)	LYFFCNZNQDPZQW-UHFFFAOYSA-N	369016	US12527775, Compound I-035	5-hydroxytryptamine receptor 2C	Homo sapiens	>100								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369016	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369016&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90000899	402365814							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207962	Cc1nc(CN(C(=O)NCc2ccc(OCC(C)C)cc2)C2CCN(C)CC2)no1	InChI=1S/C22H33N5O3/c1-16(2)15-29-20-7-5-18(6-8-20)13-23-22(28)27(14-21-24-17(3)30-25-21)19-9-11-26(4)12-10-19/h5-8,16,19H,9-15H2,1-4H3,(H,23,28)	ZWEZYYYLDZHMGS-UHFFFAOYSA-N	369017	US12527775, Compound I-036	5-hydroxytryptamine receptor 2C	Homo sapiens	>100								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369017	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369017&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90114519	402365815							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207963	CC(C)COc1ccc(CNC(=O)N(Cc2nccc3ccccc23)C2CCN(C)CC2)cc1	InChI=1S/C28H36N4O2/c1-21(2)20-34-25-10-8-22(9-11-25)18-30-28(33)32(24-13-16-31(3)17-14-24)19-27-26-7-5-4-6-23(26)12-15-29-27/h4-12,15,21,24H,13-14,16-20H2,1-3H3,(H,30,33)	FLRJHFZZGWVKIZ-UHFFFAOYSA-N	369018	US12527775, Compound I-038	5-hydroxytryptamine receptor 2C	Homo sapiens	>100								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369018	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369018&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90114579	402365816							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207964	CC(C)COc1ccc(CNC(=O)N(Cc2cccc3ccncc23)C2CCN(C)CC2)cc1	InChI=1S/C28H36N4O2/c1-21(2)20-34-26-9-7-22(8-10-26)17-30-28(33)32(25-12-15-31(3)16-13-25)19-24-6-4-5-23-11-14-29-18-27(23)24/h4-11,14,18,21,25H,12-13,15-17,19-20H2,1-3H3,(H,30,33)	ZZOWTQXOBWYWMW-UHFFFAOYSA-N	369019	US12527775, Compound I-039	5-hydroxytryptamine receptor 2C	Homo sapiens	>100								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369019	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369019&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90115081	402365817							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207965	CC(C)COc1ccc(CNC(=O)N(Cc2cccc3cccnc23)C2CCN(C)CC2)cc1	InChI=1S/C28H36N4O2/c1-21(2)20-34-26-11-9-22(10-12-26)18-30-28(33)32(25-13-16-31(3)17-14-25)19-24-7-4-6-23-8-5-15-29-27(23)24/h4-12,15,21,25H,13-14,16-20H2,1-3H3,(H,30,33)	UXXLYNFVVYUHQB-UHFFFAOYSA-N	369020	US12527775, Compound I-040	5-hydroxytryptamine receptor 2C	Homo sapiens	 55								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369020	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369020&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90114568	402365818							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207966	CC(C)COc1ccc(CNC(=O)N(Cc2cccc3cc[nH]c23)C2CCN(C)CC2)cc1	InChI=1S/C27H36N4O2/c1-20(2)19-33-25-9-7-21(8-10-25)17-29-27(32)31(24-12-15-30(3)16-13-24)18-23-6-4-5-22-11-14-28-26(22)23/h4-11,14,20,24,28H,12-13,15-19H2,1-3H3,(H,29,32)	FPGIWIKXPQUPSY-UHFFFAOYSA-N	369021	US12527775, Compound I-041	5-hydroxytryptamine receptor 2C	Homo sapiens	 55								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369021	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369021&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90115480	402365819							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207967	CN1CCC(CC1)N(Cc1ccc(F)cn1)C(=O)NCc1ccc2OCCc2c1	InChI=1S/C22H27FN4O2/c1-26-9-6-20(7-10-26)27(15-19-4-3-18(23)14-24-19)22(28)25-13-16-2-5-21-17(12-16)8-11-29-21/h2-5,12,14,20H,6-11,13,15H2,1H3,(H,25,28)	PPSQBTQKEGJNIN-UHFFFAOYSA-N	631407	US20230348421, Compound 46::US12527775, Compound I-044	5-hydroxytryptamine receptor 2C	Homo sapiens	>100								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=631407	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=631407&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			169490291	485658885							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207968	CN1CCC(N(Cc2ccc(F)cn2)C(=O)NCc2ccc3c(c2)CCCO3)CC1	InChI=1S/C23H29FN4O2/c1-27-10-8-21(9-11-27)28(16-20-6-5-19(24)15-25-20)23(29)26-14-17-4-7-22-18(13-17)3-2-12-30-22/h4-7,13,15,21H,2-3,8-12,14,16H2,1H3,(H,26,29)	BCJTVODADNLPKB-UHFFFAOYSA-N	369023	US12527775, Compound I-045	5-hydroxytryptamine receptor 2C	Homo sapiens	>100								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369023	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369023&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90114815	402365821							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207969	CN1CCC(N(Cc2ccc(F)cn2)C(=O)NCc2ccc(OCC3CC3)cc2)CC1	InChI=1S/C24H31FN4O2/c1-28-12-10-22(11-13-28)29(16-21-7-6-20(25)15-26-21)24(30)27-14-18-4-8-23(9-5-18)31-17-19-2-3-19/h4-9,15,19,22H,2-3,10-14,16-17H2,1H3,(H,27,30)	KSDCXENHKYJIIX-UHFFFAOYSA-N	369024	US12527775, Compound I-046	5-hydroxytryptamine receptor 2C	Homo sapiens	 55								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369024	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369024&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90114937	402365822							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207970	CCCOc1ccc(CNC(=O)N(Cc2ccc(F)cn2)C2CCN(C)CC2)cc1	InChI=1S/C23H31FN4O2/c1-3-14-30-22-8-4-18(5-9-22)15-26-23(29)28(21-10-12-27(2)13-11-21)17-20-7-6-19(24)16-25-20/h4-9,16,21H,3,10-15,17H2,1-2H3,(H,26,29)	KJDMYSQHMUGNEZ-UHFFFAOYSA-N	369025	US12527775, Compound I-047	5-hydroxytryptamine receptor 2C	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369025	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369025&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90115201	402365823							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207971	CN1CCC(N(Cc2ccc(F)cn2)C(=O)NCc2ccc(OC(F)F)cc2)CC1	InChI=1S/C21H25F3N4O2/c1-27-10-8-18(9-11-27)28(14-17-5-4-16(22)13-25-17)21(29)26-12-15-2-6-19(7-3-15)30-20(23)24/h2-7,13,18,20H,8-12,14H2,1H3,(H,26,29)	MFFWUTDXXDCBPF-UHFFFAOYSA-N	369026	US12527775, Compound I-048	5-hydroxytryptamine receptor 2C	Homo sapiens	 55								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369026	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369026&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90114650	402365824							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207972	CC(C)COc1ccc(CNC(=O)N(Cc2ccc(F)cn2)C2CCN(C)CC2(F)F)cc1	InChI=1S/C24H31F3N4O2/c1-17(2)15-33-21-8-4-18(5-9-21)12-29-23(32)31(14-20-7-6-19(25)13-28-20)22-10-11-30(3)16-24(22,26)27/h4-9,13,17,22H,10-12,14-16H2,1-3H3,(H,29,32)	BPSHPSWTIJXILI-UHFFFAOYSA-N	369027	US12527775, Compound I-049	5-hydroxytryptamine receptor 2C	Homo sapiens	 55								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369027	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369027&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90115437	402365825							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207973	CC(C)COc1ccc(CNC(=O)N(Cc2ccc(F)cn2)C2CCN(C)CC23CC3)cc1	InChI=1S/C26H35FN4O2/c1-19(2)17-33-23-8-4-20(5-9-23)14-29-25(32)31(16-22-7-6-21(27)15-28-22)24-10-13-30(3)18-26(24)11-12-26/h4-9,15,19,24H,10-14,16-18H2,1-3H3,(H,29,32)	HGGAPXYKOUETOQ-UHFFFAOYSA-N	369028	US12527775, Compound I-050	5-hydroxytryptamine receptor 2C	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369028	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369028&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90114257	402365826							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207974	CC(C)COc1ccc(CNC(=O)N(Cc2ccc(F)cn2)C2CCNCC23CC3)cc1	InChI=1S/C25H33FN4O2/c1-18(2)16-32-22-7-3-19(4-8-22)13-29-24(31)30(15-21-6-5-20(26)14-28-21)23-9-12-27-17-25(23)10-11-25/h3-8,14,18,23,27H,9-13,15-17H2,1-2H3,(H,29,31)	PRFDXHWUJFCOLY-UHFFFAOYSA-N	369029	US12527775, Compound I-051	5-hydroxytryptamine receptor 2C	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369029	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369029&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90114318	402365827							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207975	CC(C)COc1ccc(CNC(=O)N(Cc2ccc(F)cn2)[C@@H]2CCN3CCC[C@@H]3C2)cc1	InChI=1S/C26H35FN4O2/c1-19(2)18-33-25-9-5-20(6-10-25)15-29-26(32)31(17-22-8-7-21(27)16-28-22)24-11-13-30-12-3-4-23(30)14-24/h5-10,16,19,23-24H,3-4,11-15,17-18H2,1-2H3,(H,29,32)	GWOGXDIRRJDHMT-UHFFFAOYSA-N	369030	US12527775, Compound I-052	5-hydroxytryptamine receptor 2C	Homo sapiens	 55								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369030	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369030&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90115291	402365828							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207976	CC(C)COc1ccc(CNC(=O)N(Cc2ccc(F)cn2)[C@@H]2CCN3CCC[C@H]3C2)cc1	InChI=1S/C26H35FN4O2/c1-19(2)18-33-25-9-5-20(6-10-25)15-29-26(32)31(17-22-8-7-21(27)16-28-22)24-11-13-30-12-3-4-23(30)14-24/h5-10,16,19,23-24H,3-4,11-15,17-18H2,1-2H3,(H,29,32)	GWOGXDIRRJDHMT-UHFFFAOYSA-N	369031	US12527775, Compound I-053	5-hydroxytryptamine receptor 2C	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369031	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369031&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90114667	402365829							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207977	O=C(NCc1ccc(OC(F)F)cc1)N(Cc1ccc(F)cn1)[C@@H]1CCNC[C@@H]1F	InChI=1S/C20H22F4N4O2/c21-14-3-4-15(26-10-14)12-28(18-7-8-25-11-17(18)22)20(29)27-9-13-1-5-16(6-2-13)30-19(23)24/h1-6,10,17-19,25H,7-9,11-12H2,(H,27,29)	KSUJAUJCXHKBOR-UHFFFAOYSA-N	369032	US12527775, Compound I-054	5-hydroxytryptamine receptor 2C	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369032	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369032&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90114574	402365830							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207978	CN1CC[C@@H](N(Cc2ccc(F)cn2)C(=O)NCc2ccc(OC(F)F)cc2)[C@@H](F)C1	InChI=1S/C21H24F4N4O2/c1-28-9-8-19(18(23)13-28)29(12-16-5-4-15(22)11-26-16)21(30)27-10-14-2-6-17(7-3-14)31-20(24)25/h2-7,11,18-20H,8-10,12-13H2,1H3,(H,27,30)	DGHDMWYXYQSLON-UHFFFAOYSA-N	369033	US12527775, Compound I-055	5-hydroxytryptamine receptor 2C	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369033	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369033&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90114086	402365831							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207979	CCCOc1ccc(CNC(=O)N(Cc2ccc(F)cn2)[C@@H]2CCNC[C@@H]2F)cc1	InChI=1S/C22H28F2N4O2/c1-2-11-30-19-7-3-16(4-8-19)12-27-22(29)28(21-9-10-25-14-20(21)24)15-18-6-5-17(23)13-26-18/h3-8,13,20-21,25H,2,9-12,14-15H2,1H3,(H,27,29)	ZFBKJFMKDYQXOV-UHFFFAOYSA-N	369034	US12527775, Compound I-056	5-hydroxytryptamine receptor 2C	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369034	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369034&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90114441	402365832							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207980	CCCOc1ccc(CNC(=O)N(Cc2ccc(F)cn2)[C@@H]2CCN(C)C[C@@H]2F)cc1	InChI=1S/C23H30F2N4O2/c1-3-12-31-20-8-4-17(5-9-20)13-27-23(30)29(15-19-7-6-18(24)14-26-19)22-10-11-28(2)16-21(22)25/h4-9,14,21-22H,3,10-13,15-16H2,1-2H3,(H,27,30)	IEBKHWQGGYMJFB-UHFFFAOYSA-N	369035	US12527775, Compound I-057	5-hydroxytryptamine receptor 2C	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369035	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369035&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90114664	402365833							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207981	CC(C)COc1ccc(CNC(=O)N(Cc2ccc(F)cn2)[C@@H]2CCNC[C@@H]2F)cc1	InChI=1S/C23H30F2N4O2/c1-16(2)15-31-20-7-3-17(4-8-20)11-28-23(30)29(22-9-10-26-13-21(22)25)14-19-6-5-18(24)12-27-19/h3-8,12,16,21-22,26H,9-11,13-15H2,1-2H3,(H,28,30)	WAIOOCMTXRBLQC-UHFFFAOYSA-N	369036	US12527775, Compound I-058	5-hydroxytryptamine receptor 2C	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369036	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369036&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90115290	402365834							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207982	CC(C)COc1ccc(CNC(=O)N(Cc2ccc(F)cn2)[C@@H]2CCN(C)C[C@@H]2F)cc1	InChI=1S/C24H32F2N4O2/c1-17(2)16-32-21-8-4-18(5-9-21)12-28-24(31)30(14-20-7-6-19(25)13-27-20)23-10-11-29(3)15-22(23)26/h4-9,13,17,22-23H,10-12,14-16H2,1-3H3,(H,28,31)	RELRUDTWGGXBJF-UHFFFAOYSA-N	369037	US12527775, Compound I-059	5-hydroxytryptamine receptor 2C	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369037	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369037&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90115009	402365835							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207983	COc1ccc(CNC(=O)N(Cc2ccc(F)cn2)C2CCNCC23CC3)cc1	InChI=1S/C22H27FN4O2/c1-29-19-6-2-16(3-7-19)12-26-21(28)27(14-18-5-4-17(23)13-25-18)20-8-11-24-15-22(20)9-10-22/h2-7,13,20,24H,8-12,14-15H2,1H3,(H,26,28)	HSDJYQCCXZKKAQ-UHFFFAOYSA-N	369038	US12527775, Compound I-060	5-hydroxytryptamine receptor 2C	Homo sapiens	 55								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369038	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369038&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90114894	402365836							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207984	COc1ccc(CNC(=O)N(Cc2ccc(F)cn2)C2CCN(C)CC23CC3)cc1	InChI=1S/C23H29FN4O2/c1-27-12-9-21(23(16-27)10-11-23)28(15-19-6-5-18(24)14-25-19)22(29)26-13-17-3-7-20(30-2)8-4-17/h3-8,14,21H,9-13,15-16H2,1-2H3,(H,26,29)	QWGQPPNQHPIMAS-UHFFFAOYSA-N	369039	US12527775, Compound I-061	5-hydroxytryptamine receptor 2C	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369039	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369039&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90115415	402365837							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207985	CCCOc1ccc(CNC(=O)N(Cc2ccc(F)cn2)C2CCNCC23CC3)cc1	InChI=1S/C24H31FN4O2/c1-2-13-31-21-7-3-18(4-8-21)14-28-23(30)29(16-20-6-5-19(25)15-27-20)22-9-12-26-17-24(22)10-11-24/h3-8,15,22,26H,2,9-14,16-17H2,1H3,(H,28,30)	BDTWDALLCFDLQP-UHFFFAOYSA-N	369040	US12527775, Compound I-062	5-hydroxytryptamine receptor 2C	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369040	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369040&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90114962	402365838							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207986	CCCOc1ccc(CNC(=O)N(Cc2ccc(F)cn2)C2CCN(C)CC23CC3)cc1	InChI=1S/C25H33FN4O2/c1-3-14-32-22-8-4-19(5-9-22)15-28-24(31)30(17-21-7-6-20(26)16-27-21)23-10-13-29(2)18-25(23)11-12-25/h4-9,16,23H,3,10-15,17-18H2,1-2H3,(H,28,31)	HTMVOJQJHVQXIO-UHFFFAOYSA-N	369041	US12527775, Compound I-063	5-hydroxytryptamine receptor 2C	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369041	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369041&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90115121	402365839							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207987	CC(C)COc1ccc(CNC(=O)N(Cc2ccn(C)n2)C2CCN(C)CC23CC3)cc1	InChI=1S/C25H37N5O2/c1-19(2)17-32-22-7-5-20(6-8-22)15-26-24(31)30(16-21-9-14-29(4)27-21)23-10-13-28(3)18-25(23)11-12-25/h5-9,14,19,23H,10-13,15-18H2,1-4H3,(H,26,31)	LIQILROYDQMRBR-UHFFFAOYSA-N	369042	US12527775, Compound I-064	5-hydroxytryptamine receptor 2C	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369042	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369042&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90114617	402365840							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207988	CCCOc1ccc(CNC(=O)N(Cc2ccn(C)n2)C2CCN(C)CC23CC3)cc1	InChI=1S/C24H35N5O2/c1-4-15-31-21-7-5-19(6-8-21)16-25-23(30)29(17-20-9-14-28(3)26-20)22-10-13-27(2)18-24(22)11-12-24/h5-9,14,22H,4,10-13,15-18H2,1-3H3,(H,25,30)	HOVLTWZHAUDSGN-UHFFFAOYSA-N	369043	US12527775, Compound I-065	5-hydroxytryptamine receptor 2C	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369043	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369043&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90114854	402365841							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207989	O=C(NCc1ccc(OCC2CC2)cc1)N(Cc1ccc(F)cn1)C1CCNCC12CC2	InChI=1S/C25H31FN4O2/c26-20-5-6-21(28-14-20)15-30(23-9-12-27-17-25(23)10-11-25)24(31)29-13-18-3-7-22(8-4-18)32-16-19-1-2-19/h3-8,14,19,23,27H,1-2,9-13,15-17H2,(H,29,31)	MFQJPPKXTFIDCS-UHFFFAOYSA-N	369044	US12527775, Compound I-066	5-hydroxytryptamine receptor 2C	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369044	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369044&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90115173	402365842							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207990	CN1CCC(N(Cc2ccc(F)cn2)C(=O)NCc2ccc(OCC3CC3)cc2)C2(CC2)C1	InChI=1S/C26H33FN4O2/c1-30-13-10-24(26(18-30)11-12-26)31(16-22-7-6-21(27)15-28-22)25(32)29-14-19-4-8-23(9-5-19)33-17-20-2-3-20/h4-9,15,20,24H,2-3,10-14,16-18H2,1H3,(H,29,32)	XKYAGYGTSUAWDO-UHFFFAOYSA-N	369045	US12527775, Compound I-067	5-hydroxytryptamine receptor 2C	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369045	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369045&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90114543	402365843							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207991	CC(C)COc1ccc(CNC(=O)N(Cc2ncccc2F)[C@@H]2CCN(C)C[C@@H]2F)cc1	InChI=1S/C24H32F2N4O2/c1-17(2)16-32-19-8-6-18(7-9-19)13-28-24(31)30(15-22-20(25)5-4-11-27-22)23-10-12-29(3)14-21(23)26/h4-9,11,17,21,23H,10,12-16H2,1-3H3,(H,28,31)	BFJPGRVEPQGNKG-UHFFFAOYSA-N	369046	US12527775, Compound I-069	5-hydroxytryptamine receptor 2C	Homo sapiens	>100								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369046	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369046&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90001568	402365844							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207992	CC(C)COc1ccc(CNC(=O)N(Cc2ccc(F)c3cccnc23)C2CCN(C)CC2)cc1	InChI=1S/C28H35FN4O2/c1-20(2)19-35-24-9-6-21(7-10-24)17-31-28(34)33(23-12-15-32(3)16-13-23)18-22-8-11-26(29)25-5-4-14-30-27(22)25/h4-11,14,20,23H,12-13,15-19H2,1-3H3,(H,31,34)	QAXKVARPGQRGFE-UHFFFAOYSA-N	369047	US12527775, Compound I-070	5-hydroxytryptamine receptor 2C	Homo sapiens	 55								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369047	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369047&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90001583	402365845							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207993	CC(C)COc1ccc(CNC(=O)N(Cc2ncccc2F)[C@@H]2CCNC[C@@H]2F)cc1	InChI=1S/C23H30F2N4O2/c1-16(2)15-31-18-7-5-17(6-8-18)12-28-23(30)29(22-9-11-26-13-20(22)25)14-21-19(24)4-3-10-27-21/h3-8,10,16,20,22,26H,9,11-15H2,1-2H3,(H,28,30)	XKSZKJUILWLDNC-UHFFFAOYSA-N	369048	US12527775, Compound I-073	5-hydroxytryptamine receptor 2C	Homo sapiens	>100								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369048	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369048&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90000883	402365846							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207994	CC(C)COc1ccc(CNC(=O)N(Cc2cn(C)c3cccnc23)C2CCN(C)CC2)cc1	InChI=1S/C27H37N5O2/c1-20(2)19-34-24-9-7-21(8-10-24)16-29-27(33)32(23-11-14-30(3)15-12-23)18-22-17-31(4)25-6-5-13-28-26(22)25/h5-10,13,17,20,23H,11-12,14-16,18-19H2,1-4H3,(H,29,33)	FIQTZPQWSUGONN-UHFFFAOYSA-N	369049	US12527775, Compound I-074	5-hydroxytryptamine receptor 2C	Homo sapiens	 55								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369049	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369049&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90001154	402365847							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207995	CC(C)COc1ccc(CNC(=O)N(Cc2ncc(O)cc2F)C2CCN(C)CC2)cc1	InChI=1S/C24H33FN4O3/c1-17(2)16-32-21-6-4-18(5-7-21)13-27-24(31)29(19-8-10-28(3)11-9-19)15-23-22(25)12-20(30)14-26-23/h4-7,12,14,17,19,30H,8-11,13,15-16H2,1-3H3,(H,27,31)	RDZRYWBMFPMUKT-UHFFFAOYSA-N	369050	US12527775, Compound I-077	5-hydroxytryptamine receptor 2C	Homo sapiens	>100								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369050	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369050&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90001141	402365848							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207996	Cc1cnc(CN(C(=O)NCc2ccc(OCC(C)C)cc2)C2CCN(C)CC2)cn1	InChI=1S/C24H35N5O2/c1-18(2)17-31-23-7-5-20(6-8-23)14-27-24(30)29(22-9-11-28(4)12-10-22)16-21-15-25-19(3)13-26-21/h5-8,13,15,18,22H,9-12,14,16-17H2,1-4H3,(H,27,30)	GPOHSDBYYDCRNX-UHFFFAOYSA-N	369051	US12527775, Compound I-078	5-hydroxytryptamine receptor 2C	Homo sapiens	>100								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369051	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369051&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90001897	402365849							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207997	CC(C)COc1ccc(CNC(=O)N(Cc2cn(C)c3ccccc23)C2CCN(C)CC2)cc1	InChI=1S/C28H38N4O2/c1-21(2)20-34-25-11-9-22(10-12-25)17-29-28(33)32(24-13-15-30(3)16-14-24)19-23-18-31(4)27-8-6-5-7-26(23)27/h5-12,18,21,24H,13-17,19-20H2,1-4H3,(H,29,33)	OVLSMBMUUVSBKE-UHFFFAOYSA-N	369052	US12527775, Compound I-079	5-hydroxytryptamine receptor 2C	Homo sapiens	>100								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369052	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369052&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90001674	402365850							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207998	CC(C)COc1ccc(CNC(=O)N(Cc2ncc(F)cc2O)C2CCN(C)CC2)cc1	InChI=1S/C24H33FN4O3/c1-17(2)16-32-21-6-4-18(5-7-21)13-27-24(31)29(20-8-10-28(3)11-9-20)15-22-23(30)12-19(25)14-26-22/h4-7,12,14,17,20,30H,8-11,13,15-16H2,1-3H3,(H,27,31)	JVQQJSQFDKFGQG-UHFFFAOYSA-N	369053	US12527775, Compound I-080	5-hydroxytryptamine receptor 2C	Homo sapiens	 55								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369053	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369053&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90115113	402365851							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
207999	CC(C)COc1ccc(CNC(=O)N(Cc2ccc(F)c3cc[nH]c23)C2CCN(C)CC2)cc1	InChI=1S/C27H35FN4O2/c1-19(2)18-34-23-7-4-20(5-8-23)16-30-27(33)32(22-11-14-31(3)15-12-22)17-21-6-9-25(28)24-10-13-29-26(21)24/h4-10,13,19,22,29H,11-12,14-18H2,1-3H3,(H,30,33)	PQUWOVGMBSCSIR-UHFFFAOYSA-N	369054	US12527775, Compound I-081	5-hydroxytryptamine receptor 2C	Homo sapiens	>100								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369054	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369054&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90114502	402365852							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
208000	C=Cc1ccc(CNC(=O)N(Cc2ccc(F)cn2)C2CCN(C)CC2)cc1	InChI=1S/C22H27FN4O/c1-3-17-4-6-18(7-5-17)14-25-22(28)27(21-10-12-26(2)13-11-21)16-20-9-8-19(23)15-24-20/h3-9,15,21H,1,10-14,16H2,2H3,(H,25,28)	WMWKGQVFSOQGDY-UHFFFAOYSA-N	369055	US12527775, Compound I-083	5-hydroxytryptamine receptor 2C	Homo sapiens	 55								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369055	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369055&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90114928	402365853							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
208001	CCCOc1ccc(CNC(=O)N(Cc2ccn(C)n2)[C@@H]2CCN(C)CC23CC3)cc1	InChI=1S/C24H35N5O2/c1-4-15-31-21-7-5-19(6-8-21)16-25-23(30)29(17-20-9-14-28(3)26-20)22-10-13-27(2)18-24(22)11-12-24/h5-9,14,22H,4,10-13,15-18H2,1-3H3,(H,25,30)	HOVLTWZHAUDSGN-UHFFFAOYSA-N	369056	US12527775, Compound I-086	5-hydroxytryptamine receptor 2C	Homo sapiens	>100								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369056	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369056&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90114769	402365854							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
208002	CC(C)COc1ccc(CNC(=O)N(Cc2ccn(C)n2)[C@@H]2CCN(C)CC23CC3)cc1	InChI=1S/C25H37N5O2/c1-19(2)17-32-22-7-5-20(6-8-22)15-26-24(31)30(16-21-9-14-29(4)27-21)23-10-13-28(3)18-25(23)11-12-25/h5-9,14,19,23H,10-13,15-18H2,1-4H3,(H,26,31)	LIQILROYDQMRBR-UHFFFAOYSA-N	369057	US12527775, Compound I-087	5-hydroxytryptamine receptor 2C	Homo sapiens	 55								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369057	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369057&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90115141	402365855							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
208003	CC(C)COc1ccc(CNC(=O)N(Cc2ccc(F)cn2)C2CCN(C)C(CO)C2)cc1	InChI=1S/C25H35FN4O3/c1-18(2)17-33-24-8-4-19(5-9-24)13-28-25(32)30(15-21-7-6-20(26)14-27-21)22-10-11-29(3)23(12-22)16-31/h4-9,14,18,22-23,31H,10-13,15-17H2,1-3H3,(H,28,32)	HXXWCRJKNCZJSE-UHFFFAOYSA-N	369058	US12527775, Compound I-089	5-hydroxytryptamine receptor 2C	Homo sapiens	 55								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369058	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369058&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90114452	402365856							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
208004	CC(C)COc1ccc(CNC(=O)N(Cc2ccn(C)n2)C2CCNCC23CC3)cc1	InChI=1S/C24H35N5O2/c1-18(2)16-31-21-6-4-19(5-7-21)14-26-23(30)29(15-20-9-13-28(3)27-20)22-8-12-25-17-24(22)10-11-24/h4-7,9,13,18,22,25H,8,10-12,14-17H2,1-3H3,(H,26,30)	LCEUKLLCELNFRI-UHFFFAOYSA-N	369059	US12527775, Compound I-090	5-hydroxytryptamine receptor 2C	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369059	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369059&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90115062	402365857							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
208005	CC(C)COc1ccc(CNC(=O)N(Cc2ccc(F)cn2)C2CCNCC2(F)F)cc1	InChI=1S/C23H29F3N4O2/c1-16(2)14-32-20-7-3-17(4-8-20)11-29-22(31)30(13-19-6-5-18(24)12-28-19)21-9-10-27-15-23(21,25)26/h3-8,12,16,21,27H,9-11,13-15H2,1-2H3,(H,29,31)	UDGIUWDEFGCBPL-UHFFFAOYSA-N	369060	US12527775, Compound I-091	5-hydroxytryptamine receptor 2C	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369060	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369060&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90114389	402365858							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
208006	CN1CCC(N(Cc2ccc(F)cn2)C(=O)NCc2ccc(OCC(C)(F)F)cc2)CC1	InChI=1S/C23H29F3N4O2/c1-23(25,26)16-32-21-7-3-17(4-8-21)13-28-22(31)30(20-9-11-29(2)12-10-20)15-19-6-5-18(24)14-27-19/h3-8,14,20H,9-13,15-16H2,1-2H3,(H,28,31)	OOZJVBZAJFDWPM-UHFFFAOYSA-N	369061	US12527775, Compound I-092	5-hydroxytryptamine receptor 2C	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369061	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369061&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90114431	402365859							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
208007	CC(C)COc1ccc(CNC(=O)N(Cc2ccn(C)c2)[C@@H]2CCNC[C@@H]2F)cc1	InChI=1S/C23H33FN4O2/c1-17(2)16-30-20-6-4-18(5-7-20)12-26-23(29)28(15-19-9-11-27(3)14-19)22-8-10-25-13-21(22)24/h4-7,9,11,14,17,21-22,25H,8,10,12-13,15-16H2,1-3H3,(H,26,29)	WXBLNXYIJLJMGY-UHFFFAOYSA-N	369062	US12527775, Compound I-093	5-hydroxytryptamine receptor 2C	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369062	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369062&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90114899	402365860							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
208008	Cc1cc(CN(C(=O)NCc2ccc(OCC(C)C)cc2)C2CCN(C)CC23CC3)nn1C	InChI=1S/C26H39N5O2/c1-19(2)17-33-23-8-6-21(7-9-23)15-27-25(32)31(16-22-14-20(3)30(5)28-22)24-10-13-29(4)18-26(24)11-12-26/h6-9,14,19,24H,10-13,15-18H2,1-5H3,(H,27,32)	UPJOFLCBVKGEMD-UHFFFAOYSA-N	369063	US12527775, Compound I-094	5-hydroxytryptamine receptor 2C	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369063	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369063&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90114885	402365861							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
208009	CN1CCC(CC1)N(Cc1ccc(F)cn1)C(=O)NCc1ccc(OCC(F)(F)F)cc1	InChI=1S/C22H26F4N4O2/c1-29-10-8-19(9-11-29)30(14-18-5-4-17(23)13-27-18)21(31)28-12-16-2-6-20(7-3-16)32-15-22(24,25)26/h2-7,13,19H,8-12,14-15H2,1H3,(H,28,31)	HCPZGSLTHYYAJZ-UHFFFAOYSA-N	50596723	CHEMBL5205903::US20230348421, Compound 59::US12527775, Compound I-095	5-hydroxytryptamine receptor 2C	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50596723	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50596723&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			168286940	482607575							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
208010	Cc1cc(CN(C(=O)NCc2ccc(OCC(C)C)cc2)C2CCN(C)CC2)nn1C	InChI=1S/C24H37N5O2/c1-18(2)17-31-23-8-6-20(7-9-23)15-25-24(30)29(22-10-12-27(4)13-11-22)16-21-14-19(3)28(5)26-21/h6-9,14,18,22H,10-13,15-17H2,1-5H3,(H,25,30)	XCTQDZOAWGTATR-UHFFFAOYSA-N	369065	US12527775, Compound I-096	5-hydroxytryptamine receptor 2C	Homo sapiens	 55								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369065	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369065&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90115434	402365863							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
208011	C[C@H](F)COc1ccc(CNC(=O)N(Cc2ccc(F)cn2)C2CCN(C)CC2)cc1	InChI=1S/C23H30F2N4O2/c1-17(24)16-31-22-7-3-18(4-8-22)13-27-23(30)29(21-9-11-28(2)12-10-21)15-20-6-5-19(25)14-26-20/h3-8,14,17,21H,9-13,15-16H2,1-2H3,(H,27,30)	UXWCRWYGIJZKIL-UHFFFAOYSA-N	369066	US12527775, Compound I-097	5-hydroxytryptamine receptor 2C	Homo sapiens	 55								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369066	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369066&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90114315	402365864							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
208012	C[C@@H](F)COc1ccc(CNC(=O)N(Cc2ccc(F)cn2)C2CCN(C)CC2)cc1	InChI=1S/C23H30F2N4O2/c1-17(24)16-31-22-7-3-18(4-8-22)13-27-23(30)29(21-9-11-28(2)12-10-21)15-20-6-5-19(25)14-26-20/h3-8,14,17,21H,9-13,15-16H2,1-2H3,(H,27,30)	UXWCRWYGIJZKIL-UHFFFAOYSA-N	369067	US12527775, Compound I-098	5-hydroxytryptamine receptor 2C	Homo sapiens	 55								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369067	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369067&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90114378	402365865							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
208013	COc1ccc(CNC(=O)N(Cc2ccc(F)cn2)C2CCN(C)CC23CC3)cc1	InChI=1S/C23H29FN4O2/c1-27-12-9-21(23(16-27)10-11-23)28(15-19-6-5-18(24)14-25-19)22(29)26-13-17-3-7-20(30-2)8-4-17/h3-8,14,21H,9-13,15-16H2,1-2H3,(H,26,29)	QWGQPPNQHPIMAS-UHFFFAOYSA-N	369068	US12527775, Compound I-099	5-hydroxytryptamine receptor 2C	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369068	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369068&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90115381	402365866							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
208014	Cc1ccc(CNC(=O)N(Cc2ccc(F)cn2)C2CCN(C)CC23CC3)cc1	InChI=1S/C23H29FN4O/c1-17-3-5-18(6-4-17)13-26-22(29)28(15-20-8-7-19(24)14-25-20)21-9-12-27(2)16-23(21)10-11-23/h3-8,14,21H,9-13,15-16H2,1-2H3,(H,26,29)	FKFURHGVBTVPEX-UHFFFAOYSA-N	369069	US12527775, Compound I-100	5-hydroxytryptamine receptor 2C	Homo sapiens	 55								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369069	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369069&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90114547	402365867							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
208015	Cc1ccc(CNC(=O)N(Cc2ccc(F)cn2)C2CCNCC23CC3)cc1	InChI=1S/C22H27FN4O/c1-16-2-4-17(5-3-16)12-26-21(28)27(14-19-7-6-18(23)13-25-19)20-8-11-24-15-22(20)9-10-22/h2-7,13,20,24H,8-12,14-15H2,1H3,(H,26,28)	JOJQHCHWEBXDFA-UHFFFAOYSA-N	369070	US12527775, Compound I-101	5-hydroxytryptamine receptor 2C	Homo sapiens	 55								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369070	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369070&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90115355	402365868							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
208016	CC(C)COc1ccc(CNC(=O)N(Cc2ccc(F)cn2)[C@H]2CCN(C)C[C@H]2F)cc1	InChI=1S/C24H32F2N4O2/c1-17(2)16-32-21-8-4-18(5-9-21)12-28-24(31)30(14-20-7-6-19(25)13-27-20)23-10-11-29(3)15-22(23)26/h4-9,13,17,22-23H,10-12,14-16H2,1-3H3,(H,28,31)	RELRUDTWGGXBJF-UHFFFAOYSA-N	369071	US12527775, Compound I-103	5-hydroxytryptamine receptor 2C	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369071	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369071&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90114595	402365869							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
208017	COc1ccc(CNC(=O)N(Cc2cc(C)n(C)n2)C2CCN(C)CC23CC3)cc1	InChI=1S/C23H33N5O2/c1-17-13-19(25-27(17)3)15-28(21-9-12-26(2)16-23(21)10-11-23)22(29)24-14-18-5-7-20(30-4)8-6-18/h5-8,13,21H,9-12,14-16H2,1-4H3,(H,24,29)	OSXJWIZOZORKAS-UHFFFAOYSA-N	369072	US12527775, Compound I-104	5-hydroxytryptamine receptor 2C	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369072	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369072&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90113978	402365870							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
208018	Cc1ccc(CNC(=O)N(Cc2cc(C)n(C)n2)C2CCN(C)CC23CC3)cc1	InChI=1S/C23H33N5O/c1-17-5-7-19(8-6-17)14-24-22(29)28(15-20-13-18(2)27(4)25-20)21-9-12-26(3)16-23(21)10-11-23/h5-8,13,21H,9-12,14-16H2,1-4H3,(H,24,29)	PGAZILYDJHZGLJ-UHFFFAOYSA-N	369073	US12527775, Compound I-105	5-hydroxytryptamine receptor 2C	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369073	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369073&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90114686	402365871							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
208019	COc1ccc(COC(=O)N(Cc2ccn(C)c2)C2CCN(C)CC2)cc1	InChI=1S/C21H29N3O3/c1-22-12-9-19(10-13-22)24(15-18-8-11-23(2)14-18)21(25)27-16-17-4-6-20(26-3)7-5-17/h4-8,11,14,19H,9-10,12-13,15-16H2,1-3H3	OCQAPICTWWOQTQ-UHFFFAOYSA-N	369074	US12527775, Compound I-106	5-hydroxytryptamine receptor 2C	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369074	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369074&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90114963	402365872							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
208020	CCCOc1ccc(CNC(=O)N(Cc2ccn(C)n2)C2CCNCC23CC3)cc1	InChI=1S/C23H33N5O2/c1-3-14-30-20-6-4-18(5-7-20)15-25-22(29)28(16-19-9-13-27(2)26-19)21-8-12-24-17-23(21)10-11-23/h4-7,9,13,21,24H,3,8,10-12,14-17H2,1-2H3,(H,25,29)	KZFQBYVIYNQALR-UHFFFAOYSA-N	369075	US12527775, Compound I-107	5-hydroxytryptamine receptor 2C	Homo sapiens	 55								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369075	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369075&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90114811	402365873							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
208021	CC(C)COc1ccc(CNC(=O)N(Cc2ccn(C)c2)[C@@H]2CCN(C)C[C@@H]2F)cc1	InChI=1S/C24H35FN4O2/c1-18(2)17-31-21-7-5-19(6-8-21)13-26-24(30)29(15-20-9-11-27(3)14-20)23-10-12-28(4)16-22(23)25/h5-9,11,14,18,22-23H,10,12-13,15-17H2,1-4H3,(H,26,30)	GVKKJHCFUNJLAI-UHFFFAOYSA-N	369076	US12527775, Compound I-108	5-hydroxytryptamine receptor 2C	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369076	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369076&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			89993998	402365874							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
208022	CCCOc1ccc(CNC(=O)N(Cc2cc(C)n(C)n2)C2CCN(C)CC23CC3)cc1	InChI=1S/C25H37N5O2/c1-5-14-32-22-8-6-20(7-9-22)16-26-24(31)30(17-21-15-19(2)29(4)27-21)23-10-13-28(3)18-25(23)11-12-25/h6-9,15,23H,5,10-14,16-18H2,1-4H3,(H,26,31)	BOKIASHIRMLMKK-UHFFFAOYSA-N	369077	US12527775, Compound I-109	5-hydroxytryptamine receptor 2C	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369077	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369077&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90115036	402365875							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
208023	CN1CCC(N(Cc2ccn(C)n2)C(=O)NCc2ccc(OCC3CC3)cc2)C2(CC2)C1	InChI=1S/C25H35N5O2/c1-28-13-10-23(25(18-28)11-12-25)30(16-21-9-14-29(2)27-21)24(31)26-15-19-5-7-22(8-6-19)32-17-20-3-4-20/h5-9,14,20,23H,3-4,10-13,15-18H2,1-2H3,(H,26,31)	ILDRACNCXJXBPV-UHFFFAOYSA-N	369078	US12527775, Compound I-110	5-hydroxytryptamine receptor 2C	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369078	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369078&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90114180	402365876							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
208024	CN1CCC(N(Cc2ccn(C)n2)C(=O)NCc2ccc(OC(F)F)cc2)C2(CC2)C1	InChI=1S/C22H29F2N5O2/c1-27-11-8-19(22(15-27)9-10-22)29(14-17-7-12-28(2)26-17)21(30)25-13-16-3-5-18(6-4-16)31-20(23)24/h3-7,12,19-20H,8-11,13-15H2,1-2H3,(H,25,30)	OFFWBFAGOYTFBS-UHFFFAOYSA-N	369079	US12527775, Compound I-111	5-hydroxytryptamine receptor 2C	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369079	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369079&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90114354	402365877							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
208025	CC(C)CNc1ccc(CNC(=O)N(Cc2ccc(F)cn2)C2CCN(C)CC2)cc1	InChI=1S/C24H34FN5O/c1-18(2)14-26-21-7-4-19(5-8-21)15-28-24(31)30(23-10-12-29(3)13-11-23)17-22-9-6-20(25)16-27-22/h4-9,16,18,23,26H,10-15,17H2,1-3H3,(H,28,31)	HLCSDQGWTAVIIG-UHFFFAOYSA-N	369080	US12527775, Compound I-112	5-hydroxytryptamine receptor 2C	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369080	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369080&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90114874	402365878							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
208026	CN1CCC(N(Cc2ccc(F)cn2)C(=O)NCc2ccc(OC3CC3)cc2)CC1	InChI=1S/C23H29FN4O2/c1-27-12-10-20(11-13-27)28(16-19-5-4-18(24)15-25-19)23(29)26-14-17-2-6-21(7-3-17)30-22-8-9-22/h2-7,15,20,22H,8-14,16H2,1H3,(H,26,29)	ABISKCRCWSKHNS-UHFFFAOYSA-N	369081	US12527775, Compound I-113	5-hydroxytryptamine receptor 2C	Homo sapiens	 55								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369081	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369081&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90115264	402365879							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
208027	CC(C)COc1ccc(CNC(=O)N(Cc2ccn(C)n2)[C@H]2CCN(C)CC23CC3)cc1	InChI=1S/C25H37N5O2/c1-19(2)17-32-22-7-5-20(6-8-22)15-26-24(31)30(16-21-9-14-29(4)27-21)23-10-13-28(3)18-25(23)11-12-25/h5-9,14,19,23H,10-13,15-18H2,1-4H3,(H,26,31)	LIQILROYDQMRBR-UHFFFAOYSA-N	50645460	CHEMBL5569065::US12527775, Compound I-114	5-hydroxytryptamine receptor 2C	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50645460	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50645460&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			169811703	519660862							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
208028	CC(C)COc1ccc(CNC(=O)N(Cc2ccc(F)cn2)[C@H]2CCNC[C@H]2F)cc1	InChI=1S/C23H30F2N4O2/c1-16(2)15-31-20-7-3-17(4-8-20)11-28-23(30)29(22-9-10-26-13-21(22)25)14-19-6-5-18(24)12-27-19/h3-8,12,16,21-22,26H,9-11,13-15H2,1-2H3,(H,28,30)	WAIOOCMTXRBLQC-UHFFFAOYSA-N	369083	US12527775, Compound I-115	5-hydroxytryptamine receptor 2C	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369083	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369083&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90114394	402365881							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
208029	CN1CCC(N(Cc2ccc(F)cn2)C(=O)NCc2ccc(OCC(F)(F)C(F)F)cc2)CC1	InChI=1S/C23H27F5N4O2/c1-31-10-8-19(9-11-31)32(14-18-5-4-17(24)13-29-18)22(33)30-12-16-2-6-20(7-3-16)34-15-23(27,28)21(25)26/h2-7,13,19,21H,8-12,14-15H2,1H3,(H,30,33)	ZWFQFKQAPWDFPL-UHFFFAOYSA-N	369084	US12527775, Compound I-117	5-hydroxytryptamine receptor 2C	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369084	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369084&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90114191	402365882							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
208030	CC(C)COc1ccc(CNC(=O)N(Cc2ccn(C(F)F)n2)C2CCN(C)CC2)cc1	InChI=1S/C23H33F2N5O2/c1-17(2)16-32-21-6-4-18(5-7-21)14-26-23(31)29(20-9-11-28(3)12-10-20)15-19-8-13-30(27-19)22(24)25/h4-8,13,17,20,22H,9-12,14-16H2,1-3H3,(H,26,31)	SKLASZRMEYXCFM-UHFFFAOYSA-N	369085	US12527775, Compound I-118	5-hydroxytryptamine receptor 2C	Homo sapiens	 55								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369085	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369085&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90114462	402365883							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
208031	CCCOc1ccc(CNC(=O)N(Cc2ccc(F)cn2)[C@H]2CCNC[C@H]2F)cc1	InChI=1S/C22H28F2N4O2/c1-2-11-30-19-7-3-16(4-8-19)12-27-22(29)28(21-9-10-25-14-20(21)24)15-18-6-5-17(23)13-26-18/h3-8,13,20-21,25H,2,9-12,14-15H2,1H3,(H,27,29)	ZFBKJFMKDYQXOV-UHFFFAOYSA-N	369086	US12527775, Compound I-119	5-hydroxytryptamine receptor 2C	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369086	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369086&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90114395	402365884							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
208032	Cc1ccc(CNC(=O)N(Cc2ccc(F)cn2)[C@H]2CCN(C)CC23CC3)cc1	InChI=1S/C23H29FN4O/c1-17-3-5-18(6-4-17)13-26-22(29)28(15-20-8-7-19(24)14-25-20)21-9-12-27(2)16-23(21)10-11-23/h3-8,14,21H,9-13,15-16H2,1-2H3,(H,26,29)	FKFURHGVBTVPEX-UHFFFAOYSA-N	369087	US12527775, Compound I-120	5-hydroxytryptamine receptor 2C	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369087	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369087&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90114747	402365885							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
208033	CN1CCC(N(Cc2ccc(F)cn2)C(=O)NCc2ccc(N(C)C)cc2)CC1	InChI=1S/C22H30FN5O/c1-26(2)20-8-4-17(5-9-20)14-25-22(29)28(21-10-12-27(3)13-11-21)16-19-7-6-18(23)15-24-19/h4-9,15,21H,10-14,16H2,1-3H3,(H,25,29)	TYQZCRCTMUNSFI-UHFFFAOYSA-N	369088	US12527775, Compound I-121	5-hydroxytryptamine receptor 2C	Homo sapiens	>100								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369088	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369088&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90114177	402365886							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
208034	CCCOc1ccc(CNC(=O)N(Cc2ccn(C)n2)[C@H]2CCNC[C@H]2F)cc1	InChI=1S/C21H30FN5O2/c1-3-12-29-18-6-4-16(5-7-18)13-24-21(28)27(15-17-9-11-26(2)25-17)20-8-10-23-14-19(20)22/h4-7,9,11,19-20,23H,3,8,10,12-15H2,1-2H3,(H,24,28)	KUGBHIAPXRVEQI-UHFFFAOYSA-N	369089	US12527775, Compound I-122	5-hydroxytryptamine receptor 2C	Homo sapiens	 55								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369089	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369089&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90114813	402365887							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
208035	CCCOc1ccc(CNC(=O)N(Cc2cc(C)n(C)n2)[C@H]2CCNC[C@H]2F)cc1	InChI=1S/C22H32FN5O2/c1-4-11-30-19-7-5-17(6-8-19)13-25-22(29)28(21-9-10-24-14-20(21)23)15-18-12-16(2)27(3)26-18/h5-8,12,20-21,24H,4,9-11,13-15H2,1-3H3,(H,25,29)	HPIYWAVCZKKHEU-UHFFFAOYSA-N	369090	US12527775, Compound I-123	5-hydroxytryptamine receptor 2C	Homo sapiens	 55								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369090	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369090&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90115131	402365888							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
208036	CN1CCC(N(Cc2ccc(F)cn2)C(=O)NCc2ccc(C3CC3)cc2)CC1	InChI=1S/C23H29FN4O/c1-27-12-10-22(11-13-27)28(16-21-9-8-20(24)15-25-21)23(29)26-14-17-2-4-18(5-3-17)19-6-7-19/h2-5,8-9,15,19,22H,6-7,10-14,16H2,1H3,(H,26,29)	XDFZHAZZPAAWGC-UHFFFAOYSA-N	369091	US12527775, Compound I-125	5-hydroxytryptamine receptor 2C	Homo sapiens	 55								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369091	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369091&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90114465	402365889							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
208037	CCCOc1ccc(CNC(=O)N(Cc2cc(C)n(C)n2)[C@@H]2CCN(C)CC23CC3)cc1	InChI=1S/C25H37N5O2/c1-5-14-32-22-8-6-20(7-9-22)16-26-24(31)30(17-21-15-19(2)29(4)27-21)23-10-13-28(3)18-25(23)11-12-25/h6-9,15,23H,5,10-14,16-18H2,1-4H3,(H,26,31)	BOKIASHIRMLMKK-UHFFFAOYSA-N	369092	US12527775, Compound I-127	5-hydroxytryptamine receptor 2C	Homo sapiens	>100								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369092	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369092&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90115063	402365890							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
208038	Cc1cc(CN(C(=O)NCc2ccc(OCC(C)C)cc2)C2CCN(C)CC2)nn1CF	InChI=1S/C24H36FN5O2/c1-18(2)16-32-23-7-5-20(6-8-23)14-26-24(31)29(22-9-11-28(4)12-10-22)15-21-13-19(3)30(17-25)27-21/h5-8,13,18,22H,9-12,14-17H2,1-4H3,(H,26,31)	FCXBXAQMSYIWOD-UHFFFAOYSA-N	369093	US12527775, Compound I-128	5-hydroxytryptamine receptor 2C	Homo sapiens	 55								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369093	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369093&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90114661	402365891							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
208039	COCc1ccc(CNC(=O)N(Cc2ccc(F)cn2)C2CCN(C)CC2)cc1	InChI=1S/C22H29FN4O2/c1-26-11-9-21(10-12-26)27(15-20-8-7-19(23)14-24-20)22(28)25-13-17-3-5-18(6-4-17)16-29-2/h3-8,14,21H,9-13,15-16H2,1-2H3,(H,25,28)	APBCSXZLJDLXAC-UHFFFAOYSA-N	369094	US12527775, Compound I-131	5-hydroxytryptamine receptor 2C	Homo sapiens	>100								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369094	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369094&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90114958	402365892							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
208040	CC(C)COc1ccc(CNC(=O)N(Cc2ccn(C)n2)[C@H]2CCNC[C@H]2F)cc1	InChI=1S/C22H32FN5O2/c1-16(2)15-30-19-6-4-17(5-7-19)12-25-22(29)28(14-18-9-11-27(3)26-18)21-8-10-24-13-20(21)23/h4-7,9,11,16,20-21,24H,8,10,12-15H2,1-3H3,(H,25,29)	IPMREZXAURGMJI-UHFFFAOYSA-N	369095	US12527775, Compound I-132	5-hydroxytryptamine receptor 2C	Homo sapiens	 55								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369095	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369095&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90115109	402365893							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
208041	Cc1cc(CN(C(=O)NCc2ccc(OCC(C)C)cc2)[C@H]2CCNC[C@H]2F)nn1C	InChI=1S/C23H34FN5O2/c1-16(2)15-31-20-7-5-18(6-8-20)12-26-23(30)29(22-9-10-25-13-21(22)24)14-19-11-17(3)28(4)27-19/h5-8,11,16,21-22,25H,9-10,12-15H2,1-4H3,(H,26,30)	HCJPZHCBWYPSIV-UHFFFAOYSA-N	369096	US12527775, Compound I-133	5-hydroxytryptamine receptor 2C	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369096	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369096&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90114587	402365894							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
208042	CC(C)COc1ccc(CNC(=O)N(Cc2cc(F)n(C)n2)C2CCN(C)CC2)cc1	InChI=1S/C23H34FN5O2/c1-17(2)16-31-21-7-5-18(6-8-21)14-25-23(30)29(20-9-11-27(3)12-10-20)15-19-13-22(24)28(4)26-19/h5-8,13,17,20H,9-12,14-16H2,1-4H3,(H,25,30)	QMSCKKGZGBFQNY-UHFFFAOYSA-N	369097	US12527775, Compound I-135	5-hydroxytryptamine receptor 2C	Homo sapiens	 55								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369097	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369097&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90114893	402365895							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
208043	CC(C)C(=O)Nc1ccc(CNC(=O)N(Cc2ccc(F)cn2)C2CCN(C)CC2)cc1	InChI=1S/C24H32FN5O2/c1-17(2)23(31)28-20-7-4-18(5-8-20)14-27-24(32)30(22-10-12-29(3)13-11-22)16-21-9-6-19(25)15-26-21/h4-9,15,17,22H,10-14,16H2,1-3H3,(H,27,32)(H,28,31)	KCQYMXHUGNIKGF-UHFFFAOYSA-N	369098	US12527775, Compound I-137	5-hydroxytryptamine receptor 2C	Homo sapiens	>100								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369098	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369098&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90115292	402365896							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
208044	Cc1cc(CN(C(=O)NCc2ccc(OCC(C)C)cc2)[C@H]2CCN(C)C[C@H]2F)nn1C	InChI=1S/C24H36FN5O2/c1-17(2)16-32-21-8-6-19(7-9-21)13-26-24(31)30(14-20-12-18(3)29(5)27-20)23-10-11-28(4)15-22(23)25/h6-9,12,17,22-23H,10-11,13-16H2,1-5H3,(H,26,31)	RPIFEWACQSQQEQ-UHFFFAOYSA-N	369099	US12527775, Compound I-138	5-hydroxytryptamine receptor 2C	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369099	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369099&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			89993988	402365897							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
208045	CC(C)COc1ccc(CNC(=O)N(Cc2ccn(C)c2)[C@H]2CCN(C)C[C@H]2F)cc1	InChI=1S/C24H35FN4O2/c1-18(2)17-31-21-7-5-19(6-8-21)13-26-24(30)29(15-20-9-11-27(3)14-20)23-10-12-28(4)16-22(23)25/h5-9,11,14,18,22-23H,10,12-13,15-17H2,1-4H3,(H,26,30)	GVKKJHCFUNJLAI-UHFFFAOYSA-N	369100	US12527775, Compound I-140	5-hydroxytryptamine receptor 2C	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369100	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369100&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90114845	402365898							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
208046	CCCOc1ccc(CNC(=O)N(Cc2ccn(C)c2)[C@H]2CCN(C)C[C@H]2F)cc1	InChI=1S/C23H33FN4O2/c1-4-13-30-20-7-5-18(6-8-20)14-25-23(29)28(16-19-9-11-26(2)15-19)22-10-12-27(3)17-21(22)24/h5-9,11,15,21-22H,4,10,12-14,16-17H2,1-3H3,(H,25,29)	PUMOTCVLDTYGHU-UHFFFAOYSA-N	369101	US12527775, Compound I-141	5-hydroxytryptamine receptor 2C	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369101	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369101&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90114936	402365899							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
208047	CC(C)COc1ccc(CNC(=O)N(Cc2cc[nH]c2)C2CCN(C)CC2)cc1	InChI=1S/C23H34N4O2/c1-18(2)17-29-22-6-4-19(5-7-22)15-25-23(28)27(16-20-8-11-24-14-20)21-9-12-26(3)13-10-21/h4-8,11,14,18,21,24H,9-10,12-13,15-17H2,1-3H3,(H,25,28)	AWVWSGLBFZHRNY-UHFFFAOYSA-N	369102	US12527775, Compound I-142	5-hydroxytryptamine receptor 2C	Homo sapiens	>100								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369102	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369102&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90114858	402365900							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
208048	CC(C)COc1ccc(CNC(=O)N(Cc2cc[nH]n2)C2CCN(C)CC2)cc1	InChI=1S/C22H33N5O2/c1-17(2)16-29-21-6-4-18(5-7-21)14-23-22(28)27(15-19-8-11-24-25-19)20-9-12-26(3)13-10-20/h4-8,11,17,20H,9-10,12-16H2,1-3H3,(H,23,28)(H,24,25)	HRRFYAWWLLIVHO-UHFFFAOYSA-N	369103	US12527775, Compound I-143	5-hydroxytryptamine receptor 2C	Homo sapiens	>100								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369103	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369103&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90114475	402365901							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
208049	Cc1cc(CN(C(=O)NCc2ccc(OCC(C)C)cc2)C2CCN(C)CC2)cn1C	InChI=1S/C25H38N4O2/c1-19(2)18-31-24-8-6-21(7-9-24)15-26-25(30)29(23-10-12-27(4)13-11-23)17-22-14-20(3)28(5)16-22/h6-9,14,16,19,23H,10-13,15,17-18H2,1-5H3,(H,26,30)	MZKJGGSGYAKAHN-UHFFFAOYSA-N	369104	US12527775, Compound I-144	5-hydroxytryptamine receptor 2C	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369104	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369104&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90114541	402365902							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
208050	CC(C)COc1ccc(CNC(=O)N(Cc2cc(CF)n(C)n2)[C@H]2CCNC[C@H]2F)cc1	InChI=1S/C23H33F2N5O2/c1-16(2)15-32-20-6-4-17(5-7-20)12-27-23(31)30(22-8-9-26-13-21(22)25)14-18-10-19(11-24)29(3)28-18/h4-7,10,16,21-22,26H,8-9,11-15H2,1-3H3,(H,27,31)	JIQRANRWXAAFAI-UHFFFAOYSA-N	369105	US12527775, Compound I-145	5-hydroxytryptamine receptor 2C	Homo sapiens	<10								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369105	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369105&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90114569	402365903							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
208051	CC(C)COc1ccc(CNC(=O)N(Cc2cocn2)C2CCN(C)CC2)cc1	InChI=1S/C22H32N4O3/c1-17(2)14-29-21-6-4-18(5-7-21)12-23-22(27)26(13-19-15-28-16-24-19)20-8-10-25(3)11-9-20/h4-7,15-17,20H,8-14H2,1-3H3,(H,23,27)	AGKSXEOEBBFAEM-UHFFFAOYSA-N	369106	US12527775, Compound I-148	5-hydroxytryptamine receptor 2C	Homo sapiens	>100								US Patent	10.1111/j.1747-0285.2007.00551.x	10.7270/Q2Z89J77			US12527775	Nakahara, K; Fuchino, K; Nagatani, K	1/20/2026	6/1/2026	Shionogi	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369106	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3430&target=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369106&enzyme=5-hydroxytryptamine+receptor+2C&column=ki&startPg=0&Increment=50&submit=Search			90114801	402365904							1	MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV	8DPI,8DPH,9UGL	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	P28335	B1AMW4 Q5VUF8 Q9NP28