BindingDB Reactant_set_id	Ligand SMILES	Ligand InChI	Ligand InChI Key	BindingDB MonomerID	BindingDB Ligand Name	Target Name	Target Source Organism According to Curator or DataSource	Ki (nM)	IC50 (nM)	Kd (nM)	EC50 (nM)	kon (M-1-s-1)	koff (s-1)	pH	Temp (C)	Curation/DataSource	Article DOI	BindingDB Entry DOI	PMID	PubChem AID	Patent Number	Authors	Date of publication	Date in BindingDB	Institution	Link to Ligand in BindingDB	Link to Target in BindingDB	Link to Ligand-Target Pair in BindingDB	Ligand HET ID in PDB	PDB ID(s) for Ligand-Target Complex	PubChem CID	PubChem SID	ChEBI ID of Ligand	ChEMBL ID of Ligand	DrugBank ID of Ligand	IUPHAR_GRAC ID of Ligand	KEGG ID of Ligand	ZINC ID of Ligand	Number of Protein Chains in Target (>1 implies a multichain complex)	BindingDB Target Chain Sequence 1	PDB ID(s) of Target Chain 1	UniProt (SwissProt) Recommended Name of Target Chain 1	UniProt (SwissProt) Entry Name of Target Chain 1	UniProt (SwissProt) Primary ID of Target Chain 1	UniProt (SwissProt) Secondary ID(s) of Target Chain 1	UniProt (SwissProt) Alternative ID(s) of Target Chain 1	UniProt (TrEMBL) Submitted Name of Target Chain 1	UniProt (TrEMBL) Entry Name of Target Chain 1	UniProt (TrEMBL) Primary ID of Target Chain 1	UniProt (TrEMBL) Secondary ID(s) of Target Chain 1	UniProt (TrEMBL) Alternative ID(s) of Target Chain 1	BindingDB Target Chain Sequence 2	PDB ID(s) of Target Chain 2	UniProt (SwissProt) Recommended Name of Target Chain 2	UniProt (SwissProt) Entry Name of Target Chain 2	UniProt (SwissProt) Primary ID of Target Chain 2	UniProt (SwissProt) Secondary ID(s) of Target Chain 2	UniProt (SwissProt) Alternative ID(s) of Target Chain 2	UniProt (TrEMBL) Submitted Name of Target Chain 2	UniProt (TrEMBL) Entry Name of Target Chain 2	UniProt (TrEMBL) Primary ID of Target Chain 2	UniProt (TrEMBL) Secondary ID(s) of Target Chain 2	UniProt (TrEMBL) Alternative ID(s) of Target Chain 2	BindingDB Target Chain Sequence 3	PDB ID(s) of Target Chain 3	UniProt (SwissProt) Recommended Name of Target Chain 3	UniProt (SwissProt) Entry Name of Target Chain 3	UniProt (SwissProt) Primary ID of Target Chain 3	UniProt (SwissProt) Secondary ID(s) of Target Chain 3	UniProt (SwissProt) Alternative ID(s) of Target Chain 3	UniProt (TrEMBL) Submitted Name of Target Chain 3	UniProt (TrEMBL) Entry Name of Target Chain 3	UniProt (TrEMBL) Primary ID of Target Chain 3	UniProt (TrEMBL) Secondary ID(s) of Target Chain 3	UniProt (TrEMBL) Alternative ID(s) of Target Chain 3	BindingDB Target Chain Sequence 4	PDB ID(s) of Target Chain 4	UniProt (SwissProt) Recommended Name of Target Chain 4	UniProt (SwissProt) Entry Name of Target Chain 4	UniProt (SwissProt) Primary ID of Target Chain 4	UniProt (SwissProt) Secondary ID(s) of Target Chain 4	UniProt (SwissProt) Alternative ID(s) of Target Chain 4	UniProt (TrEMBL) Submitted Name of Target Chain 4	UniProt (TrEMBL) Entry Name of Target Chain 4	UniProt (TrEMBL) Primary ID of Target Chain 4	UniProt (TrEMBL) Secondary ID(s) of Target Chain 4	UniProt (TrEMBL) Alternative ID(s) of Target Chain 4	BindingDB Target Chain Sequence 5	PDB ID(s) of Target Chain 5	UniProt (SwissProt) Recommended Name of Target Chain 5	UniProt (SwissProt) Entry Name of Target Chain 5	UniProt (SwissProt) Primary ID of Target Chain 5	UniProt (SwissProt) Secondary ID(s) of Target Chain 5	UniProt (SwissProt) Alternative ID(s) of Target Chain 5	UniProt (TrEMBL) Submitted Name of Target Chain 5	UniProt (TrEMBL) Entry Name of Target Chain 5	UniProt (TrEMBL) Primary ID of Target Chain 5	UniProt (TrEMBL) Secondary ID(s) of Target Chain 5	UniProt (TrEMBL) Alternative ID(s) of Target Chain 5	BindingDB Target Chain Sequence 6	PDB ID(s) of Target Chain 6	UniProt (SwissProt) Recommended Name of Target Chain 6	UniProt (SwissProt) Entry Name of Target Chain 6	UniProt (SwissProt) Primary ID of Target Chain 6	UniProt (SwissProt) Secondary ID(s) of Target Chain 6	UniProt (SwissProt) Alternative ID(s) of Target Chain 6	UniProt (TrEMBL) Submitted Name of Target Chain 6	UniProt (TrEMBL) Entry Name of Target Chain 6	UniProt (TrEMBL) Primary ID of Target Chain 6	UniProt (TrEMBL) Secondary ID(s) of Target Chain 6	UniProt (TrEMBL) Alternative ID(s) of Target Chain 6	BindingDB Target Chain Sequence 7	PDB ID(s) of Target Chain 7	UniProt (SwissProt) Recommended Name of Target Chain 7	UniProt (SwissProt) Entry Name of Target Chain 7	UniProt (SwissProt) Primary ID of Target Chain 7	UniProt (SwissProt) Secondary ID(s) of Target Chain 7	UniProt (SwissProt) Alternative ID(s) of Target Chain 7	UniProt (TrEMBL) Submitted Name of Target Chain 7	UniProt (TrEMBL) Entry Name of Target Chain 7	UniProt (TrEMBL) Primary ID of Target Chain 7	UniProt (TrEMBL) Secondary ID(s) of Target Chain 7	UniProt (TrEMBL) Alternative ID(s) of Target Chain 7	BindingDB Target Chain Sequence 8	PDB ID(s) of Target Chain 8	UniProt (SwissProt) Recommended Name of Target Chain 8	UniProt (SwissProt) Entry Name of Target Chain 8	UniProt (SwissProt) Primary ID of Target Chain 8	UniProt (SwissProt) Secondary ID(s) of Target Chain 8	UniProt (SwissProt) Alternative ID(s) of Target Chain 8	UniProt (TrEMBL) Submitted Name of Target Chain 8	UniProt (TrEMBL) Entry Name of Target Chain 8	UniProt (TrEMBL) Primary ID of Target Chain 8	UniProt (TrEMBL) Secondary ID(s) of Target Chain 8	UniProt (TrEMBL) Alternative ID(s) of Target Chain 8	BindingDB Target Chain Sequence 9	PDB ID(s) of Target Chain 9	UniProt (SwissProt) Recommended Name of Target Chain 9	UniProt (SwissProt) Entry Name of Target Chain 9	UniProt (SwissProt) Primary ID of Target Chain 9	UniProt (SwissProt) Secondary ID(s) of Target Chain 9	UniProt (SwissProt) Alternative ID(s) of Target Chain 9	UniProt (TrEMBL) Submitted Name of Target Chain 9	UniProt (TrEMBL) Entry Name of Target Chain 9	UniProt (TrEMBL) Primary ID of Target Chain 9	UniProt (TrEMBL) Secondary ID(s) of Target Chain 9	UniProt (TrEMBL) Alternative ID(s) of Target Chain 9	BindingDB Target Chain Sequence 10	PDB ID(s) of Target Chain 10	UniProt (SwissProt) Recommended Name of Target Chain 10	UniProt (SwissProt) Entry Name of Target Chain 10	UniProt (SwissProt) Primary ID of Target Chain 10	UniProt (SwissProt) Secondary ID(s) of Target Chain 10	UniProt (SwissProt) Alternative ID(s) of Target Chain 10	UniProt (TrEMBL) Submitted Name of Target Chain 10	UniProt (TrEMBL) Entry Name of Target Chain 10	UniProt (TrEMBL) Primary ID of Target Chain 10	UniProt (TrEMBL) Secondary ID(s) of Target Chain 10	UniProt (TrEMBL) Alternative ID(s) of Target Chain 10	BindingDB Target Chain Sequence 11	PDB ID(s) of Target Chain 11	UniProt (SwissProt) Recommended Name of Target Chain 11	UniProt (SwissProt) Entry Name of Target Chain 11	UniProt (SwissProt) Primary ID of Target Chain 11	UniProt (SwissProt) Secondary ID(s) of Target Chain 11	UniProt (SwissProt) Alternative ID(s) of Target Chain 11	UniProt (TrEMBL) Submitted Name of Target Chain 11	UniProt (TrEMBL) Entry Name of Target Chain 11	UniProt (TrEMBL) Primary ID of Target Chain 11	UniProt (TrEMBL) Secondary ID(s) of Target Chain 11	UniProt (TrEMBL) Alternative ID(s) of Target Chain 11	BindingDB Target Chain Sequence 12	PDB ID(s) of Target Chain 12	UniProt (SwissProt) Recommended Name of Target Chain 12	UniProt (SwissProt) Entry Name of Target Chain 12	UniProt (SwissProt) Primary ID of Target Chain 12	UniProt (SwissProt) Secondary ID(s) of Target Chain 12	UniProt (SwissProt) Alternative ID(s) of Target Chain 12	UniProt (TrEMBL) Submitted Name of Target Chain 12	UniProt (TrEMBL) Entry Name of Target Chain 12	UniProt (TrEMBL) Primary ID of Target Chain 12	UniProt (TrEMBL) Secondary ID(s) of Target Chain 12	UniProt (TrEMBL) Alternative ID(s) of Target Chain 12	BindingDB Target Chain Sequence 13	PDB ID(s) of Target Chain 13	UniProt (SwissProt) Recommended Name of Target Chain 13	UniProt (SwissProt) Entry Name of Target Chain 13	UniProt (SwissProt) Primary ID of Target Chain 13	UniProt (SwissProt) Secondary ID(s) of Target Chain 13	UniProt (SwissProt) Alternative ID(s) of Target Chain 13	UniProt (TrEMBL) Submitted Name of Target Chain 13	UniProt (TrEMBL) Entry Name of Target Chain 13	UniProt (TrEMBL) Primary ID of Target Chain 13	UniProt (TrEMBL) Secondary ID(s) of Target Chain 13	UniProt (TrEMBL) Alternative ID(s) of Target Chain 13	BindingDB Target Chain Sequence 14	PDB ID(s) of Target Chain 14	UniProt (SwissProt) Recommended Name of Target Chain 14	UniProt (SwissProt) Entry Name of Target Chain 14	UniProt (SwissProt) Primary ID of Target Chain 14	UniProt (SwissProt) Secondary ID(s) of Target Chain 14	UniProt (SwissProt) Alternative ID(s) of Target Chain 14	UniProt (TrEMBL) Submitted Name of Target Chain 14	UniProt (TrEMBL) Entry Name of Target Chain 14	UniProt (TrEMBL) Primary ID of Target Chain 14	UniProt (TrEMBL) Secondary ID(s) of Target Chain 14	UniProt (TrEMBL) Alternative ID(s) of Target Chain 14	BindingDB Target Chain Sequence 15	PDB ID(s) of Target Chain 15	UniProt (SwissProt) Recommended Name of Target Chain 15	UniProt (SwissProt) Entry Name of Target Chain 15	UniProt (SwissProt) Primary ID of Target Chain 15	UniProt (SwissProt) Secondary ID(s) of Target Chain 15	UniProt (SwissProt) Alternative ID(s) of Target Chain 15	UniProt (TrEMBL) Submitted Name of Target Chain 15	UniProt (TrEMBL) Entry Name of Target Chain 15	UniProt (TrEMBL) Primary ID of Target Chain 15	UniProt (TrEMBL) Secondary ID(s) of Target Chain 15	UniProt (TrEMBL) Alternative ID(s) of Target Chain 15	BindingDB Target Chain Sequence 16	PDB ID(s) of Target Chain 16	UniProt (SwissProt) Recommended Name of Target Chain 16	UniProt (SwissProt) Entry Name of Target Chain 16	UniProt (SwissProt) Primary ID of Target Chain 16	UniProt (SwissProt) Secondary ID(s) of Target Chain 16	UniProt (SwissProt) Alternative ID(s) of Target Chain 16	UniProt (TrEMBL) Submitted Name of Target Chain 16	UniProt (TrEMBL) Entry Name of Target Chain 16	UniProt (TrEMBL) Primary ID of Target Chain 16	UniProt (TrEMBL) Secondary ID(s) of Target Chain 16	UniProt (TrEMBL) Alternative ID(s) of Target Chain 16	BindingDB Target Chain Sequence 17	PDB ID(s) of Target Chain 17	UniProt (SwissProt) Recommended Name of Target Chain 17	UniProt (SwissProt) Entry Name of Target Chain 17	UniProt (SwissProt) Primary ID of Target Chain 17	UniProt (SwissProt) Secondary ID(s) of Target Chain 17	UniProt (SwissProt) Alternative ID(s) of Target Chain 17	UniProt (TrEMBL) Submitted Name of Target Chain 17	UniProt (TrEMBL) Entry Name of Target Chain 17	UniProt (TrEMBL) Primary ID of Target Chain 17	UniProt (TrEMBL) Secondary ID(s) of Target Chain 17	UniProt (TrEMBL) Alternative ID(s) of Target Chain 17	BindingDB Target Chain Sequence 18	PDB ID(s) of Target Chain 18	UniProt (SwissProt) Recommended Name of Target Chain 18	UniProt (SwissProt) Entry Name of Target Chain 18	UniProt (SwissProt) Primary ID of Target Chain 18	UniProt (SwissProt) Secondary ID(s) of Target Chain 18	UniProt (SwissProt) Alternative ID(s) of Target Chain 18	UniProt (TrEMBL) Submitted Name of Target Chain 18	UniProt (TrEMBL) Entry Name of Target Chain 18	UniProt (TrEMBL) Primary ID of Target Chain 18	UniProt (TrEMBL) Secondary ID(s) of Target Chain 18	UniProt (TrEMBL) Alternative ID(s) of Target Chain 18	BindingDB Target Chain Sequence 19	PDB ID(s) of Target Chain 19	UniProt (SwissProt) Recommended Name of Target Chain 19	UniProt (SwissProt) Entry Name of Target Chain 19	UniProt (SwissProt) Primary ID of Target Chain 19	UniProt (SwissProt) Secondary ID(s) of Target Chain 19	UniProt (SwissProt) Alternative ID(s) of Target Chain 19	UniProt (TrEMBL) Submitted Name of Target Chain 19	UniProt (TrEMBL) Entry Name of Target Chain 19	UniProt (TrEMBL) Primary ID of Target Chain 19	UniProt (TrEMBL) Secondary ID(s) of Target Chain 19	UniProt (TrEMBL) Alternative ID(s) of Target Chain 19	BindingDB Target Chain Sequence 20	PDB ID(s) of Target Chain 20	UniProt (SwissProt) Recommended Name of Target Chain 20	UniProt (SwissProt) Entry Name of Target Chain 20	UniProt (SwissProt) Primary ID of Target Chain 20	UniProt (SwissProt) Secondary ID(s) of Target Chain 20	UniProt (SwissProt) Alternative ID(s) of Target Chain 20	UniProt (TrEMBL) Submitted Name of Target Chain 20	UniProt (TrEMBL) Entry Name of Target Chain 20	UniProt (TrEMBL) Primary ID of Target Chain 20	UniProt (TrEMBL) Secondary ID(s) of Target Chain 20	UniProt (TrEMBL) Alternative ID(s) of Target Chain 20	BindingDB Target Chain Sequence 21	PDB ID(s) of Target Chain 21	UniProt (SwissProt) Recommended Name of Target Chain 21	UniProt (SwissProt) Entry Name of Target Chain 21	UniProt (SwissProt) Primary ID of Target Chain 21	UniProt (SwissProt) Secondary ID(s) of Target Chain 21	UniProt (SwissProt) Alternative ID(s) of Target Chain 21	UniProt (TrEMBL) Submitted Name of Target Chain 21	UniProt (TrEMBL) Entry Name of Target Chain 21	UniProt (TrEMBL) Primary ID of Target Chain 21	UniProt (TrEMBL) Secondary ID(s) of Target Chain 21	UniProt (TrEMBL) Alternative ID(s) of Target Chain 21	BindingDB Target Chain Sequence 22	PDB ID(s) of Target Chain 22	UniProt (SwissProt) Recommended Name of Target Chain 22	UniProt (SwissProt) Entry Name of Target Chain 22	UniProt (SwissProt) Primary ID of Target Chain 22	UniProt (SwissProt) Secondary ID(s) of Target Chain 22	UniProt (SwissProt) Alternative ID(s) of Target Chain 22	UniProt (TrEMBL) Submitted Name of Target Chain 22	UniProt (TrEMBL) Entry Name of Target Chain 22	UniProt (TrEMBL) Primary ID of Target Chain 22	UniProt (TrEMBL) Secondary ID(s) of Target Chain 22	UniProt (TrEMBL) Alternative ID(s) of Target Chain 22	BindingDB Target Chain Sequence 23	PDB ID(s) of Target Chain 23	UniProt (SwissProt) Recommended Name of Target Chain 23	UniProt (SwissProt) Entry Name of Target Chain 23	UniProt (SwissProt) Primary ID of Target Chain 23	UniProt (SwissProt) Secondary ID(s) of Target Chain 23	UniProt (SwissProt) Alternative ID(s) of Target Chain 23	UniProt (TrEMBL) Submitted Name of Target Chain 23	UniProt (TrEMBL) Entry Name of Target Chain 23	UniProt (TrEMBL) Primary ID of Target Chain 23	UniProt (TrEMBL) Secondary ID(s) of Target Chain 23	UniProt (TrEMBL) Alternative ID(s) of Target Chain 23	BindingDB Target Chain Sequence 24	PDB ID(s) of Target Chain 24	UniProt (SwissProt) Recommended Name of Target Chain 24	UniProt (SwissProt) Entry Name of Target Chain 24	UniProt (SwissProt) Primary ID of Target Chain 24	UniProt (SwissProt) Secondary ID(s) of Target Chain 24	UniProt (SwissProt) Alternative ID(s) of Target Chain 24	UniProt (TrEMBL) Submitted Name of Target Chain 24	UniProt (TrEMBL) Entry Name of Target Chain 24	UniProt (TrEMBL) Primary ID of Target Chain 24	UniProt (TrEMBL) Secondary ID(s) of Target Chain 24	UniProt (TrEMBL) Alternative ID(s) of Target Chain 24	BindingDB Target Chain Sequence 25	PDB ID(s) of Target Chain 25	UniProt (SwissProt) Recommended Name of Target Chain 25	UniProt (SwissProt) Entry Name of Target Chain 25	UniProt (SwissProt) Primary ID of Target Chain 25	UniProt (SwissProt) Secondary ID(s) of Target Chain 25	UniProt (SwissProt) Alternative ID(s) of Target Chain 25	UniProt (TrEMBL) Submitted Name of Target Chain 25	UniProt (TrEMBL) Entry Name of Target Chain 25	UniProt (TrEMBL) Primary ID of Target Chain 25	UniProt (TrEMBL) Secondary ID(s) of Target Chain 25	UniProt (TrEMBL) Alternative ID(s) of Target Chain 25	BindingDB Target Chain Sequence 26	PDB ID(s) of Target Chain 26	UniProt (SwissProt) Recommended Name of Target Chain 26	UniProt (SwissProt) Entry Name of Target Chain 26	UniProt (SwissProt) Primary ID of Target Chain 26	UniProt (SwissProt) Secondary ID(s) of Target Chain 26	UniProt (SwissProt) Alternative ID(s) of Target Chain 26	UniProt (TrEMBL) Submitted Name of Target Chain 26	UniProt (TrEMBL) Entry Name of Target Chain 26	UniProt (TrEMBL) Primary ID of Target Chain 26	UniProt (TrEMBL) Secondary ID(s) of Target Chain 26	UniProt (TrEMBL) Alternative ID(s) of Target Chain 26	BindingDB Target Chain Sequence 27	PDB ID(s) of Target Chain 27	UniProt (SwissProt) Recommended Name of Target Chain 27	UniProt (SwissProt) Entry Name of Target Chain 27	UniProt (SwissProt) Primary ID of Target Chain 27	UniProt (SwissProt) Secondary ID(s) of Target Chain 27	UniProt (SwissProt) Alternative ID(s) of Target Chain 27	UniProt (TrEMBL) Submitted Name of Target Chain 27	UniProt (TrEMBL) Entry Name of Target Chain 27	UniProt (TrEMBL) Primary ID of Target Chain 27	UniProt (TrEMBL) Secondary ID(s) of Target Chain 27	UniProt (TrEMBL) Alternative ID(s) of Target Chain 27	BindingDB Target Chain Sequence 28	PDB ID(s) of Target Chain 28	UniProt (SwissProt) Recommended Name of Target Chain 28	UniProt (SwissProt) Entry Name of Target Chain 28	UniProt (SwissProt) Primary ID of Target Chain 28	UniProt (SwissProt) Secondary ID(s) of Target Chain 28	UniProt (SwissProt) Alternative ID(s) of Target Chain 28	UniProt (TrEMBL) Submitted Name of Target Chain 28	UniProt (TrEMBL) Entry Name of Target Chain 28	UniProt (TrEMBL) Primary ID of Target Chain 28	UniProt (TrEMBL) Secondary ID(s) of Target Chain 28	UniProt (TrEMBL) Alternative ID(s) of Target Chain 28	BindingDB Target Chain Sequence 29	PDB ID(s) of Target Chain 29	UniProt (SwissProt) Recommended Name of Target Chain 29	UniProt (SwissProt) Entry Name of Target Chain 29	UniProt (SwissProt) Primary ID of Target Chain 29	UniProt (SwissProt) Secondary ID(s) of Target Chain 29	UniProt (SwissProt) Alternative ID(s) of Target Chain 29	UniProt (TrEMBL) Submitted Name of Target Chain 29	UniProt (TrEMBL) Entry Name of Target Chain 29	UniProt (TrEMBL) Primary ID of Target Chain 29	UniProt (TrEMBL) Secondary ID(s) of Target Chain 29	UniProt (TrEMBL) Alternative ID(s) of Target Chain 29	BindingDB Target Chain Sequence 30	PDB ID(s) of Target Chain 30	UniProt (SwissProt) Recommended Name of Target Chain 30	UniProt (SwissProt) Entry Name of Target Chain 30	UniProt (SwissProt) Primary ID of Target Chain 30	UniProt (SwissProt) Secondary ID(s) of Target Chain 30	UniProt (SwissProt) Alternative ID(s) of Target Chain 30	UniProt (TrEMBL) Submitted Name of Target Chain 30	UniProt (TrEMBL) Entry Name of Target Chain 30	UniProt (TrEMBL) Primary ID of Target Chain 30	UniProt (TrEMBL) Secondary ID(s) of Target Chain 30	UniProt (TrEMBL) Alternative ID(s) of Target Chain 30	BindingDB Target Chain Sequence 31	PDB ID(s) of Target Chain 31	UniProt (SwissProt) Recommended Name of Target Chain 31	UniProt (SwissProt) Entry Name of Target Chain 31	UniProt (SwissProt) Primary ID of Target Chain 31	UniProt (SwissProt) Secondary ID(s) of Target Chain 31	UniProt (SwissProt) Alternative ID(s) of Target Chain 31	UniProt (TrEMBL) Submitted Name of Target Chain 31	UniProt (TrEMBL) Entry Name of Target Chain 31	UniProt (TrEMBL) Primary ID of Target Chain 31	UniProt (TrEMBL) Secondary ID(s) of Target Chain 31	UniProt (TrEMBL) Alternative ID(s) of Target Chain 31	BindingDB Target Chain Sequence 32	PDB ID(s) of Target Chain 32	UniProt (SwissProt) Recommended Name of Target Chain 32	UniProt (SwissProt) Entry Name of Target Chain 32	UniProt (SwissProt) Primary ID of Target Chain 32	UniProt (SwissProt) Secondary ID(s) of Target Chain 32	UniProt (SwissProt) Alternative ID(s) of Target Chain 32	UniProt (TrEMBL) Submitted Name of Target Chain 32	UniProt (TrEMBL) Entry Name of Target Chain 32	UniProt (TrEMBL) Primary ID of Target Chain 32	UniProt (TrEMBL) Secondary ID(s) of Target Chain 32	UniProt (TrEMBL) Alternative ID(s) of Target Chain 32	BindingDB Target Chain Sequence 33	PDB ID(s) of Target Chain 33	UniProt (SwissProt) Recommended Name of Target Chain 33	UniProt (SwissProt) Entry Name of Target Chain 33	UniProt (SwissProt) Primary ID of Target Chain 33	UniProt (SwissProt) Secondary ID(s) of Target Chain 33	UniProt (SwissProt) Alternative ID(s) of Target Chain 33	UniProt (TrEMBL) Submitted Name of Target Chain 33	UniProt (TrEMBL) Entry Name of Target Chain 33	UniProt (TrEMBL) Primary ID of Target Chain 33	UniProt (TrEMBL) Secondary ID(s) of Target Chain 33	UniProt (TrEMBL) Alternative ID(s) of Target Chain 33	BindingDB Target Chain Sequence 34	PDB ID(s) of Target Chain 34	UniProt (SwissProt) Recommended Name of Target Chain 34	UniProt (SwissProt) Entry Name of Target Chain 34	UniProt (SwissProt) Primary ID of Target Chain 34	UniProt (SwissProt) Secondary ID(s) of Target Chain 34	UniProt (SwissProt) Alternative ID(s) of Target Chain 34	UniProt (TrEMBL) Submitted Name of Target Chain 34	UniProt (TrEMBL) Entry Name of Target Chain 34	UniProt (TrEMBL) Primary ID of Target Chain 34	UniProt (TrEMBL) Secondary ID(s) of Target Chain 34	UniProt (TrEMBL) Alternative ID(s) of Target Chain 34	BindingDB Target Chain Sequence 35	PDB ID(s) of Target Chain 35	UniProt (SwissProt) Recommended Name of Target Chain 35	UniProt (SwissProt) Entry Name of Target Chain 35	UniProt (SwissProt) Primary ID of Target Chain 35	UniProt (SwissProt) Secondary ID(s) of Target Chain 35	UniProt (SwissProt) Alternative ID(s) of Target Chain 35	UniProt (TrEMBL) Submitted Name of Target Chain 35	UniProt (TrEMBL) Entry Name of Target Chain 35	UniProt (TrEMBL) Primary ID of Target Chain 35	UniProt (TrEMBL) Secondary ID(s) of Target Chain 35	UniProt (TrEMBL) Alternative ID(s) of Target Chain 35	BindingDB Target Chain Sequence 36	PDB ID(s) of Target Chain 36	UniProt (SwissProt) Recommended Name of Target Chain 36	UniProt (SwissProt) Entry Name of Target Chain 36	UniProt (SwissProt) Primary ID of Target Chain 36	UniProt (SwissProt) Secondary ID(s) of Target Chain 36	UniProt (SwissProt) Alternative ID(s) of Target Chain 36	UniProt (TrEMBL) Submitted Name of Target Chain 36	UniProt (TrEMBL) Entry Name of Target Chain 36	UniProt (TrEMBL) Primary ID of Target Chain 36	UniProt (TrEMBL) Secondary ID(s) of Target Chain 36	UniProt (TrEMBL) Alternative ID(s) of Target Chain 36	BindingDB Target Chain Sequence 37	PDB ID(s) of Target Chain 37	UniProt (SwissProt) Recommended Name of Target Chain 37	UniProt (SwissProt) Entry Name of Target Chain 37	UniProt (SwissProt) Primary ID of Target Chain 37	UniProt (SwissProt) Secondary ID(s) of Target Chain 37	UniProt (SwissProt) Alternative ID(s) of Target Chain 37	UniProt (TrEMBL) Submitted Name of Target Chain 37	UniProt (TrEMBL) Entry Name of Target Chain 37	UniProt (TrEMBL) Primary ID of Target Chain 37	UniProt (TrEMBL) Secondary ID(s) of Target Chain 37	UniProt (TrEMBL) Alternative ID(s) of Target Chain 37	BindingDB Target Chain Sequence 38	PDB ID(s) of Target Chain 38	UniProt (SwissProt) Recommended Name of Target Chain 38	UniProt (SwissProt) Entry Name of Target Chain 38	UniProt (SwissProt) Primary ID of Target Chain 38	UniProt (SwissProt) Secondary ID(s) of Target Chain 38	UniProt (SwissProt) Alternative ID(s) of Target Chain 38	UniProt (TrEMBL) Submitted Name of Target Chain 38	UniProt (TrEMBL) Entry Name of Target Chain 38	UniProt (TrEMBL) Primary ID of Target Chain 38	UniProt (TrEMBL) Secondary ID(s) of Target Chain 38	UniProt (TrEMBL) Alternative ID(s) of Target Chain 38	BindingDB Target Chain Sequence 39	PDB ID(s) of Target Chain 39	UniProt (SwissProt) Recommended Name of Target Chain 39	UniProt (SwissProt) Entry Name of Target Chain 39	UniProt (SwissProt) Primary ID of Target Chain 39	UniProt (SwissProt) Secondary ID(s) of Target Chain 39	UniProt (SwissProt) Alternative ID(s) of Target Chain 39	UniProt (TrEMBL) Submitted Name of Target Chain 39	UniProt (TrEMBL) Entry Name of Target Chain 39	UniProt (TrEMBL) Primary ID of Target Chain 39	UniProt (TrEMBL) Secondary ID(s) of Target Chain 39	UniProt (TrEMBL) Alternative ID(s) of Target Chain 39	BindingDB Target Chain Sequence 40	PDB ID(s) of Target Chain 40	UniProt (SwissProt) Recommended Name of Target Chain 40	UniProt (SwissProt) Entry Name of Target Chain 40	UniProt (SwissProt) Primary ID of Target Chain 40	UniProt (SwissProt) Secondary ID(s) of Target Chain 40	UniProt (SwissProt) Alternative ID(s) of Target Chain 40	UniProt (TrEMBL) Submitted Name of Target Chain 40	UniProt (TrEMBL) Entry Name of Target Chain 40	UniProt (TrEMBL) Primary ID of Target Chain 40	UniProt (TrEMBL) Secondary ID(s) of Target Chain 40	UniProt (TrEMBL) Alternative ID(s) of Target Chain 40	BindingDB Target Chain Sequence 41	PDB ID(s) of Target Chain 41	UniProt (SwissProt) Recommended Name of Target Chain 41	UniProt (SwissProt) Entry Name of Target Chain 41	UniProt (SwissProt) Primary ID of Target Chain 41	UniProt (SwissProt) Secondary ID(s) of Target Chain 41	UniProt (SwissProt) Alternative ID(s) of Target Chain 41	UniProt (TrEMBL) Submitted Name of Target Chain 41	UniProt (TrEMBL) Entry Name of Target Chain 41	UniProt (TrEMBL) Primary ID of Target Chain 41	UniProt (TrEMBL) Secondary ID(s) of Target Chain 41	UniProt (TrEMBL) Alternative ID(s) of Target Chain 41	BindingDB Target Chain Sequence 42	PDB ID(s) of Target Chain 42	UniProt (SwissProt) Recommended Name of Target Chain 42	UniProt (SwissProt) Entry Name of Target Chain 42	UniProt (SwissProt) Primary ID of Target Chain 42	UniProt (SwissProt) Secondary ID(s) of Target Chain 42	UniProt (SwissProt) Alternative ID(s) of Target Chain 42	UniProt (TrEMBL) Submitted Name of Target Chain 42	UniProt (TrEMBL) Entry Name of Target Chain 42	UniProt (TrEMBL) Primary ID of Target Chain 42	UniProt (TrEMBL) Secondary ID(s) of Target Chain 42	UniProt (TrEMBL) Alternative ID(s) of Target Chain 42	BindingDB Target Chain Sequence 43	PDB ID(s) of Target Chain 43	UniProt (SwissProt) Recommended Name of Target Chain 43	UniProt (SwissProt) Entry Name of Target Chain 43	UniProt (SwissProt) Primary ID of Target Chain 43	UniProt (SwissProt) Secondary ID(s) of Target Chain 43	UniProt (SwissProt) Alternative ID(s) of Target Chain 43	UniProt (TrEMBL) Submitted Name of Target Chain 43	UniProt (TrEMBL) Entry Name of Target Chain 43	UniProt (TrEMBL) Primary ID of Target Chain 43	UniProt (TrEMBL) Secondary ID(s) of Target Chain 43	UniProt (TrEMBL) Alternative ID(s) of Target Chain 43	BindingDB Target Chain Sequence 44	PDB ID(s) of Target Chain 44	UniProt (SwissProt) Recommended Name of Target Chain 44	UniProt (SwissProt) Entry Name of Target Chain 44	UniProt (SwissProt) Primary ID of Target Chain 44	UniProt (SwissProt) Secondary ID(s) of Target Chain 44	UniProt (SwissProt) Alternative ID(s) of Target Chain 44	UniProt (TrEMBL) Submitted Name of Target Chain 44	UniProt (TrEMBL) Entry Name of Target Chain 44	UniProt (TrEMBL) Primary ID of Target Chain 44	UniProt (TrEMBL) Secondary ID(s) of Target Chain 44	UniProt (TrEMBL) Alternative ID(s) of Target Chain 44	BindingDB Target Chain Sequence 45	PDB ID(s) of Target Chain 45	UniProt (SwissProt) Recommended Name of Target Chain 45	UniProt (SwissProt) Entry Name of Target Chain 45	UniProt (SwissProt) Primary ID of Target Chain 45	UniProt (SwissProt) Secondary ID(s) of Target Chain 45	UniProt (SwissProt) Alternative ID(s) of Target Chain 45	UniProt (TrEMBL) Submitted Name of Target Chain 45	UniProt (TrEMBL) Entry Name of Target Chain 45	UniProt (TrEMBL) Primary ID of Target Chain 45	UniProt (TrEMBL) Secondary ID(s) of Target Chain 45	UniProt (TrEMBL) Alternative ID(s) of Target Chain 45	BindingDB Target Chain Sequence 46	PDB ID(s) of Target Chain 46	UniProt (SwissProt) Recommended Name of Target Chain 46	UniProt (SwissProt) Entry Name of Target Chain 46	UniProt (SwissProt) Primary ID of Target Chain 46	UniProt (SwissProt) Secondary ID(s) of Target Chain 46	UniProt (SwissProt) Alternative ID(s) of Target Chain 46	UniProt (TrEMBL) Submitted Name of Target Chain 46	UniProt (TrEMBL) Entry Name of Target Chain 46	UniProt (TrEMBL) Primary ID of Target Chain 46	UniProt (TrEMBL) Secondary ID(s) of Target Chain 46	UniProt (TrEMBL) Alternative ID(s) of Target Chain 46	BindingDB Target Chain Sequence 47	PDB ID(s) of Target Chain 47	UniProt (SwissProt) Recommended Name of Target Chain 47	UniProt (SwissProt) Entry Name of Target Chain 47	UniProt (SwissProt) Primary ID of Target Chain 47	UniProt (SwissProt) Secondary ID(s) of Target Chain 47	UniProt (SwissProt) Alternative ID(s) of Target Chain 47	UniProt (TrEMBL) Submitted Name of Target Chain 47	UniProt (TrEMBL) Entry Name of Target Chain 47	UniProt (TrEMBL) Primary ID of Target Chain 47	UniProt (TrEMBL) Secondary ID(s) of Target Chain 47	UniProt (TrEMBL) Alternative ID(s) of Target Chain 47	BindingDB Target Chain Sequence 48	PDB ID(s) of Target Chain 48	UniProt (SwissProt) Recommended Name of Target Chain 48	UniProt (SwissProt) Entry Name of Target Chain 48	UniProt (SwissProt) Primary ID of Target Chain 48	UniProt (SwissProt) Secondary ID(s) of Target Chain 48	UniProt (SwissProt) Alternative ID(s) of Target Chain 48	UniProt (TrEMBL) Submitted Name of Target Chain 48	UniProt (TrEMBL) Entry Name of Target Chain 48	UniProt (TrEMBL) Primary ID of Target Chain 48	UniProt (TrEMBL) Secondary ID(s) of Target Chain 48	UniProt (TrEMBL) Alternative ID(s) of Target Chain 48	BindingDB Target Chain Sequence 49	PDB ID(s) of Target Chain 49	UniProt (SwissProt) Recommended Name of Target Chain 49	UniProt (SwissProt) Entry Name of Target Chain 49	UniProt (SwissProt) Primary ID of Target Chain 49	UniProt (SwissProt) Secondary ID(s) of Target Chain 49	UniProt (SwissProt) Alternative ID(s) of Target Chain 49	UniProt (TrEMBL) Submitted Name of Target Chain 49	UniProt (TrEMBL) Entry Name of Target Chain 49	UniProt (TrEMBL) Primary ID of Target Chain 49	UniProt (TrEMBL) Secondary ID(s) of Target Chain 49	UniProt (TrEMBL) Alternative ID(s) of Target Chain 49	BindingDB Target Chain Sequence 50	PDB ID(s) of Target Chain 50	UniProt (SwissProt) Recommended Name of Target Chain 50	UniProt (SwissProt) Entry Name of Target Chain 50	UniProt (SwissProt) Primary ID of Target Chain 50	UniProt (SwissProt) Secondary ID(s) of Target Chain 50	UniProt (SwissProt) Alternative ID(s) of Target Chain 50	UniProt (TrEMBL) Submitted Name of Target Chain 50	UniProt (TrEMBL) Entry Name of Target Chain 50	UniProt (TrEMBL) Primary ID of Target Chain 50	UniProt (TrEMBL) Secondary ID(s) of Target Chain 50	UniProt (TrEMBL) Alternative ID(s) of Target Chain 50
191950	CCc1c(N2CCN(C(=O)c3nc(C(F)(F)F)c[nH]3)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C30H28ClF6N9O4/c1-2-20-23(43-7-9-44(10-8-43)27(49)25-38-14-21(40-25)30(35,36)37)26(48)46-28(41-24(42-46)16-5-11-50-12-6-16)45(20)15-22(47)39-19-4-3-17(13-18(19)31)29(32,33)34/h3-5,13-14H,2,6-12,15H2,1H3,(H,38,40)(H,39,47)	MABIFLYXXMWAQB-UHFFFAOYSA-N	293044	US20260015358, Example 1	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		 550							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293044	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293044&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124122914	381613329							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
191951	CCc1c(N2CCN(C(=O)c3sc4cccnc4c3N)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C33H31ClF3N9O4S/c1-2-22-27(43-10-12-44(13-11-43)31(49)28-25(38)26-23(51-28)4-3-9-39-26)30(48)46-32(41-29(42-46)18-7-14-50-15-8-18)45(22)17-24(47)40-21-6-5-19(16-20(21)34)33(35,36)37/h3-7,9,16H,2,8,10-15,17,38H2,1H3,(H,40,47)	PCZLWVVOSKXOKL-UHFFFAOYSA-N	293045	2-(6-(4-(3-Aminothieno[3,2-b]pyridine-2-carbonyl)piperazin-1-yl)-2-(3,6-dihydro-2H-pyran-4-yl)-5-ethyl-7-oxo-[1,2,4]triazolo[1,5-a]pyrimidin-4(7H)-yl)-N-(2-chloro-4-(trifluoromethyl)phenyl)acetamide::US20260015358, Example 2	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		 550							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293045	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293045&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123199	381613330							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
191952	CCc1c(N2CCN(C(=O)c3cnc4c(ccn4Cc4ccc(OC)cc4)c3O)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C41H39ClF3N9O6/c1-3-32-34(50-14-16-51(17-15-50)38(57)29-21-46-37-28(35(29)56)10-13-52(37)22-24-4-7-27(59-2)8-5-24)39(58)54-40(48-36(49-54)25-11-18-60-19-12-25)53(32)23-33(55)47-31-9-6-26(20-30(31)42)41(43,44)45/h4-11,13,20-21H,3,12,14-19,22-23H2,1-2H3,(H,46,56)(H,47,55)	HGXOJOHSKDLHRY-UHFFFAOYSA-N	293046	US20260015358, Example 3	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293046	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293046&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123317	381613331							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
191953	CCc1c(N2CCN(C(=O)c3c(O)cc(C)oc3=O)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C32H31ClF3N7O7/c1-3-22-26(40-8-10-41(11-9-40)28(46)25-23(44)14-17(2)50-30(25)48)29(47)43-31(38-27(39-43)18-6-12-49-13-7-18)42(22)16-24(45)37-21-5-4-19(15-20(21)33)32(34,35)36/h4-6,14-15,44H,3,7-13,16H2,1-2H3,(H,37,45)	MVSAKRRRCGZCSU-UHFFFAOYSA-N	293047	US20260015358, Example 4	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293047	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293047&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123177	381613332							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
191954	CCN/C(=N/CCCN(C)C)N1CCN(C2=C(CC)C(CC(=O)Nc3ccc(C(F)(F)F)cc3C)c3nc(C4=CCOCC4)nn3C2=O)CC1	InChI=1S/C35H48F3N9O3/c1-6-26-27(22-29(48)41-28-10-9-25(21-23(28)3)35(36,37)38)32-42-31(24-11-19-50-20-12-24)43-47(32)33(49)30(26)45-15-17-46(18-16-45)34(39-7-2)40-13-8-14-44(4)5/h9-11,21,27H,6-8,12-20,22H2,1-5H3,(H,39,40)(H,41,48)	LIWVRJDLYUVGGZ-UHFFFAOYSA-N	293048	US20260015358, Example 5	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		>1000							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293048	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293048&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124122936	381613333							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
191955	CCc1c(N2CCN(C(=O)c3sc4cnccc4c3N)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C33H31ClF3N9O4S/c1-2-23-27(43-9-11-44(12-10-43)31(49)28-26(38)20-5-8-39-16-24(20)51-28)30(48)46-32(41-29(42-46)18-6-13-50-14-7-18)45(23)17-25(47)40-22-4-3-19(15-21(22)34)33(35,36)37/h3-6,8,15-16H,2,7,9-14,17,38H2,1H3,(H,40,47)	YNBGMSGNFJXGSK-UHFFFAOYSA-N	293049	US20260015358, Example 6	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		 550							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293049	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293049&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123603	381613334							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
191956	CCc1c(N2CCN(C(=O)c3ncnc4cc[nH]c34)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C32H30ClF3N10O4/c1-2-23-27(43-9-11-44(12-10-43)29(48)26-25-22(5-8-37-25)38-17-39-26)30(49)46-31(41-28(42-46)18-6-13-50-14-7-18)45(23)16-24(47)40-21-4-3-19(15-20(21)33)32(34,35)36/h3-6,8,15,17,37H,2,7,9-14,16H2,1H3,(H,40,47)	BXIYDTSKEGRAGW-UHFFFAOYSA-N	293051	US20260015358, Example 7	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293051	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293051&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123477	381613335							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
191957	CCc1c(N2CCN(c3nnc(C(F)F)s3)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C28H27ClF5N9O3S/c1-2-19-21(40-7-9-41(10-8-40)27-38-37-24(47-27)22(30)31)25(45)43-26(36-23(39-43)15-5-11-46-12-6-15)42(19)14-20(44)35-18-4-3-16(13-17(18)29)28(32,33)34/h3-5,13,22H,2,6-12,14H2,1H3,(H,35,44)	LFLXHBLOGMYEMA-UHFFFAOYSA-N	293052	US20260015358, Example 8	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		>1000							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293052	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293052&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123079	381613336							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
191958	CCc1c(N2CCN(C(=O)c3cc(-c4cc(OC)ncc4F)[nH]n3)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C35H33ClF4N10O5/c1-3-27-30(47-8-10-48(11-9-47)32(52)26-16-25(44-45-26)21-15-29(54-2)41-17-23(21)37)33(53)50-34(43-31(46-50)19-6-12-55-13-7-19)49(27)18-28(51)42-24-5-4-20(14-22(24)36)35(38,39)40/h4-6,14-17H,3,7-13,18H2,1-2H3,(H,42,51)(H,44,45)	VFNRZIKUBLGIKQ-UHFFFAOYSA-N	293053	N-(2-Chloro-4-(trifluoromethyl)phenyl)-2-(2-(3,6-dihydro-2H-pyran-4-yl)-5-ethyl-6-(4-(5-(5-fluoro-2-methoxypyridin-4-yl)-1H-pyrazole-3-carbonyl)piperazin-1-yl)-7-oxo-[1,2,4]triazolo[1,5-a]pyrimidin-4(7H)-yl)acetamide::US20260015358, Example 9	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		 550							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293053	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293053&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124122952	381613337							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
191959	CCc1c(N2CCN(S(=O)(=O)CC)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C27H31ClF3N7O5S/c1-3-21-23(35-9-11-36(12-10-35)44(41,42)4-2)25(40)38-26(33-24(34-38)17-7-13-43-14-8-17)37(21)16-22(39)32-20-6-5-18(15-19(20)28)27(29,30)31/h5-7,15H,3-4,8-14,16H2,1-2H3,(H,32,39)	ZOKCZQZNOSGRQG-UHFFFAOYSA-N	293054	US20260015358, Example 11	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		 550							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293054	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293054&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123585	381613338							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
191960	CCc1c(N2CCN(C(=O)NS(=O)(=O)c3cnn(C)c3)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C30H32ClF3N10O6S/c1-3-23-25(41-8-10-42(11-9-41)29(47)39-51(48,49)20-15-35-40(2)16-20)27(46)44-28(37-26(38-44)18-6-12-50-13-7-18)43(23)17-24(45)36-22-5-4-19(14-21(22)31)30(32,33)34/h4-6,14-16H,3,7-13,17H2,1-2H3,(H,36,45)(H,39,47)	LVJDPGWZQFWKRL-UHFFFAOYSA-N	293055	US20260015358, Example 14	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293055	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293055&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123077	381613339							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
191961	CCc1c(N2CCN(C(=O)c3ncnc4cn[nH]c34)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C31H29ClF3N11O4/c1-2-22-26(43-7-9-44(10-8-43)28(48)25-24-21(14-38-41-24)36-16-37-25)29(49)46-30(40-27(42-46)17-5-11-50-12-6-17)45(22)15-23(47)39-20-4-3-18(13-19(20)32)31(33,34)35/h3-5,13-14,16H,2,6-12,15H2,1H3,(H,38,41)(H,39,47)	DVKBWYVQZCDJMT-UHFFFAOYSA-N	293056	US20260015358, Example 17	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293056	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293056&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123077	381613340							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
191962	CCc1c(N2CCN(C(=O)Nc3[nH]ncc3C(F)(F)F)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C30H29ClF6N10O4/c1-2-21-23(44-7-9-45(10-8-44)28(50)41-25-18(14-38-42-25)30(35,36)37)26(49)47-27(40-24(43-47)16-5-11-51-12-6-16)46(21)15-22(48)39-20-4-3-17(13-19(20)31)29(32,33)34/h3-5,13-14H,2,6-12,15H2,1H3,(H,39,48)(H2,38,41,42,50)	YXYDNQGAUDJLSQ-UHFFFAOYSA-N	293057	US20260015358, Example 18	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		 550							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293057	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293057&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123501	381613341							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
191963	CCc1c(N2CCN(C(=O)c3[nH]ncc3C(F)(F)F)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C30H28ClF6N9O4/c1-2-21-24(43-7-9-44(10-8-43)26(48)23-18(14-38-41-23)30(35,36)37)27(49)46-28(40-25(42-46)16-5-11-50-12-6-16)45(21)15-22(47)39-20-4-3-17(13-19(20)31)29(32,33)34/h3-5,13-14H,2,6-12,15H2,1H3,(H,38,41)(H,39,47)	YLMUCZPYPXGVLB-UHFFFAOYSA-N	293058	N-(2-Chloro-4-(trifluoromethyl)phenyl)-2-(2-(3,6-dihydro-2H-pyran-4-yl)-5-ethyl-7-oxo-6-(4-(4-(trifluoromethyl)-1H-pyrazole-5-carbonyl)piperazin-1-yl)-[1,2,4]triazolo[1,5-a]pyrimidin-4(7H)-yl)acetamide::US20260015358, Example 19	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		>1000							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293058	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293058&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123498	381613342							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
191964	CCc1c(N2CCN(C(=O)c3ncnc4cn[nH]c34)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C31H29ClF3N11O4/c1-2-22-26(43-7-9-44(10-8-43)28(48)25-24-21(14-38-41-24)36-16-37-25)29(49)46-30(40-27(42-46)17-5-11-50-12-6-17)45(22)15-23(47)39-20-4-3-18(13-19(20)32)31(33,34)35/h3-5,13-14,16H,2,6-12,15H2,1H3,(H,38,41)(H,39,47)	DVKBWYVQZCDJMT-UHFFFAOYSA-N	293059	US20260015358, Example 20	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293059	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293059&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123691	381613343							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
191965	CCc1c(N2CCN(C(=O)c3n[nH]c(=O)[nH]c3=O)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C29H28ClF3N10O6/c1-2-19-22(40-7-9-41(10-8-40)25(46)21-24(45)36-27(48)38-37-21)26(47)43-28(35-23(39-43)15-5-11-49-12-6-15)42(19)14-20(44)34-18-4-3-16(13-17(18)30)29(31,32)33/h3-5,13H,2,6-12,14H2,1H3,(H,34,44)(H2,36,38,45,48)	KHKAHBUXXHCIRZ-UHFFFAOYSA-N	293060	US20260015358, Example 22	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293060	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293060&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123691	381613344							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
191966	CCc1c(N2CCN(c3noc4cccnc34)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C31H29ClF3N9O4/c1-2-22-26(41-10-12-42(13-11-41)28-25-23(48-40-28)4-3-9-36-25)29(46)44-30(38-27(39-44)18-7-14-47-15-8-18)43(22)17-24(45)37-21-6-5-19(16-20(21)32)31(33,34)35/h3-7,9,16H,2,8,10-15,17H2,1H3,(H,37,45)	PITJLTWBMPZUSE-UHFFFAOYSA-N	293061	US20260015358, Example 23	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		>1000							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293061	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293061&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124124917	381613345							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
191967	CCc1c(N2CCN(C(=O)NS(=O)(=O)CC)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C28H32ClF3N8O6S/c1-3-21-23(37-9-11-38(12-10-37)27(43)36-47(44,45)4-2)25(42)40-26(34-24(35-40)17-7-13-46-14-8-17)39(21)16-22(41)33-20-6-5-18(15-19(20)29)28(30,31)32/h5-7,15H,3-4,8-14,16H2,1-2H3,(H,33,41)(H,36,43)	SZZLZXHHIQFHMX-UHFFFAOYSA-N	293062	US20260015358, Example 25	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293062	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293062&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124124917	381613346							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
191968	CCC(=O)N1CCN(c2c(CC)n(CC(=O)Nc3ccc(C(F)(F)F)cc3Cl)c3nc(C4=CCOCC4)nn3c2=O)CC1	InChI=1S/C28H31ClF3N7O4/c1-3-21-24(37-11-9-36(10-12-37)23(41)4-2)26(42)39-27(34-25(35-39)17-7-13-43-14-8-17)38(21)16-22(40)33-20-6-5-18(15-19(20)29)28(30,31)32/h5-7,15H,3-4,8-14,16H2,1-2H3,(H,33,40)	PIHZMYVYRYPTLC-UHFFFAOYSA-N	293063	US20260015358, Example 27	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		 550							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293063	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293063&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124124917	381613347							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
191969	CCc1c(N2CCN(S(N)(=O)=O)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C25H28ClF3N8O5S/c1-2-19-21(34-7-9-35(10-8-34)43(30,40)41)23(39)37-24(32-22(33-37)15-5-11-42-12-6-15)36(19)14-20(38)31-18-4-3-16(13-17(18)26)25(27,28)29/h3-5,13H,2,6-12,14H2,1H3,(H,31,38)(H2,30,40,41)	HKGMCOYBYKALQS-UHFFFAOYSA-N	293064	US20260015358, Example 28	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		 550							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293064	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293064&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124124917	381613348							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
191970	CCc1c(N2CCN(S(=O)(=O)NC(C)=O)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C27H30ClF3N8O6S/c1-3-21-23(36-8-10-37(11-9-36)46(43,44)35-16(2)40)25(42)39-26(33-24(34-39)17-6-12-45-13-7-17)38(21)15-22(41)32-20-5-4-18(14-19(20)28)27(29,30)31/h4-6,14H,3,7-13,15H2,1-2H3,(H,32,41)(H,35,40)	FDAJZFMWYZTGEY-UHFFFAOYSA-N	293065	US20260015358, Example 29	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293065	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293065&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123098	381613349							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
191971	CCc1c(N2CCN(C(=O)Nc3[nH]cnc3C(F)(F)F)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C30H29ClF6N10O4/c1-2-20-22(44-7-9-45(10-8-44)28(50)42-25-23(30(35,36)37)38-15-39-25)26(49)47-27(41-24(43-47)16-5-11-51-12-6-16)46(20)14-21(48)40-19-4-3-17(13-18(19)31)29(32,33)34/h3-5,13,15H,2,6-12,14H2,1H3,(H,38,39)(H,40,48)(H,42,50)	RTGJGENHGANTQK-UHFFFAOYSA-N	293066	4-(4-(2-((2-chloro-4-(trifluoromethyl)phenyl)amino)-2-oxoethyl)-2-(3,6-dihydro-2H-pyran-4-yl)-5-ethyl-7-oxo-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)-N-(4-(trifluoromethyl)-1H-imidazol-5-yl)piperazine-1-carboxamide::US20260015358, Example 30	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		 550							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293066	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293066&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123666	381613350							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
191972	CCc5c(N2CCN(C(=O)c1[nH]cnc1C(F)(F)F)CC2)c(=O)n4nc(C3=CCOCC3)nc4n5CC(=O)Nc6ccc(C(F)(F)F)cc6Cl	InChI=1S/C30H28ClF6N9O4/c1-2-20-23(43-7-9-44(10-8-43)26(48)22-24(30(35,36)37)39-15-38-22)27(49)46-28(41-25(42-46)16-5-11-50-12-6-16)45(20)14-21(47)40-19-4-3-17(13-18(19)31)29(32,33)34/h3-5,13,15H,2,6-12,14H2,1H3,(H,38,39)(H,40,47)	GZEPQSORXLRRGH-UHFFFAOYSA-N	293067	US20260015358, Example 31	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		 550							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293067	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293067&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124122984	381613351							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
191973	CCc1c(N2CCN(C(=O)c3ncsc3N)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C29H29ClF3N9O4S/c1-2-20-23(39-7-9-40(10-8-39)26(44)22-24(34)47-15-35-22)27(45)42-28(37-25(38-42)16-5-11-46-12-6-16)41(20)14-21(43)36-19-4-3-17(13-18(19)30)29(31,32)33/h3-5,13,15H,2,6-12,14,34H2,1H3,(H,36,43)	SCIWZSHZWSFVLC-UHFFFAOYSA-N	293069	US20260015358, Example 32	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		 550							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293069	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293069&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123719	381613352							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
191974	CCC(=O)N(C(=O)Cn1c(CC)c(N2CCN(S(N)(=O)=O)CC2)c(=O)n2nc(C3=CCOCC3)nc12)c1ccc(C(F)(F)F)cc1Cl	InChI=1S/C28H32ClF3N8O6S/c1-3-20-24(36-9-11-37(12-10-36)47(33,44)45)26(43)40-27(34-25(35-40)17-7-13-46-14-8-17)38(20)16-23(42)39(22(41)4-2)21-6-5-18(15-19(21)29)28(30,31)32/h5-7,15H,3-4,8-14,16H2,1-2H3,(H2,33,44,45)	NVSPSDBIJSZZJV-UHFFFAOYSA-N	293070	US20260015358, Example 35	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		 550							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293070	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293070&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123888	381613353							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
191975	CCc1c(N2CCN(C(=O)CNC(=O)OC(C)(C)C)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C32H38ClF3N8O6/c1-5-23-26(42-12-10-41(11-13-42)25(46)17-37-30(48)50-31(2,3)4)28(47)44-29(39-27(40-44)19-8-14-49-15-9-19)43(23)18-24(45)38-22-7-6-20(16-21(22)33)32(34,35)36/h6-8,16H,5,9-15,17-18H2,1-4H3,(H,37,48)(H,38,45)	NBLFBCMKMGWIEN-UHFFFAOYSA-N	293071	US20260015358, Example 37	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293071	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293071&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123837	381613354							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
191976	CCNC(=O)NCC(=O)N1CCN(c2c(CC)n(CC(=O)Nc3ccc(C(F)(F)F)cc3Cl)c3nc(C4=CCOCC4)nn3c2=O)CC1	InChI=1S/C30H35ClF3N9O5/c1-3-22-25(41-11-9-40(10-12-41)24(45)16-36-28(47)35-4-2)27(46)43-29(38-26(39-43)18-7-13-48-14-8-18)42(22)17-23(44)37-21-6-5-19(15-20(21)31)30(32,33)34/h5-7,15H,3-4,8-14,16-17H2,1-2H3,(H,37,44)(H2,35,36,47)	FWQSPLIBJSVRBB-UHFFFAOYSA-N	293072	US20260015358, Example 41	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293072	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293072&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124122858	381613355							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
191977	CCc1c(N2CCN(C(=O)c3cnc4[nH]ccc4c3O)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C33H31ClF3N9O5/c1-2-24-26(43-9-11-44(12-10-43)30(49)21-16-39-29-20(27(21)48)5-8-38-29)31(50)46-32(41-28(42-46)18-6-13-51-14-7-18)45(24)17-25(47)40-23-4-3-19(15-22(23)34)33(35,36)37/h3-6,8,15-16H,2,7,9-14,17H2,1H3,(H,40,47)(H2,38,39,48)	PTTLOIJNIXPOEV-UHFFFAOYSA-N	293073	N-(2-Chloro-4-(trifluoromethyl)phenyl)-2-(2-(3,6-dihydro-2H-pyran-4-yl)-5-ethyl-6-(4-(4-hydroxy-1H-pyrrolo[2,3-b]pyridine-5-carbonyl)piperazin-1-yl)-7-oxo-[1,2,4]triazolo[1,5-a]pyrimidin-4(7H)-yl)acetamide::US20260015358, Example 42	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293073	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293073&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123007	381613356							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
191978	CCc1c(N2CCN(C(=O)c3c[nH]c(=O)n(C)c3=O)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C31H31ClF3N9O6/c1-3-22-24(41-8-10-42(11-9-41)27(47)19-15-36-30(49)40(2)26(19)46)28(48)44-29(38-25(39-44)17-6-12-50-13-7-17)43(22)16-23(45)37-21-5-4-18(14-20(21)32)31(33,34)35/h4-6,14-15H,3,7-13,16H2,1-2H3,(H,36,49)(H,37,45)	VYPAUWQSZQUSDU-UHFFFAOYSA-N	293074	US20260015358, Example 43	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		 550							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293074	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293074&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123264	381613357							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
191979	CCc1c(N2CCN(C(=O)c3ncnc4c(Cl)c[nH]c34)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C32H29Cl2F3N10O4/c1-2-22-27(44-7-9-45(10-8-44)29(49)26-25-24(39-16-40-26)20(34)14-38-25)30(50)47-31(42-28(43-47)17-5-11-51-12-6-17)46(22)15-23(48)41-21-4-3-18(13-19(21)33)32(35,36)37/h3-5,13-14,16,38H,2,6-12,15H2,1H3,(H,41,48)	WXWAEBQOLCVUAL-UHFFFAOYSA-N	293075	US20260015358, Example 44	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		 550							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293075	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293075&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123742	381613358							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
191980	CCc1c(N2CCN(C(=O)c3cnc4ccsc4c3O)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C33H30ClF3N8O5S/c1-2-24-26(42-8-10-43(11-9-42)30(48)20-16-38-23-7-14-51-28(23)27(20)47)31(49)45-32(40-29(41-45)18-5-12-50-13-6-18)44(24)17-25(46)39-22-4-3-19(15-21(22)34)33(35,36)37/h3-5,7,14-16H,2,6,8-13,17H2,1H3,(H,38,47)(H,39,46)	JCQZBQBXMQZWHS-UHFFFAOYSA-N	293076	US20260015358, Example 45	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293076	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293076&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123386	381613359							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
191981	CCc1c(N2CCN(C(=O)c3ncc(F)cc3N)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C31H30ClF4N9O4/c1-2-23-26(42-7-9-43(10-8-42)28(47)25-21(37)14-19(33)15-38-25)29(48)45-30(40-27(41-45)17-5-11-49-12-6-17)44(23)16-24(46)39-22-4-3-18(13-20(22)32)31(34,35)36/h3-5,13-15H,2,6-12,16,37H2,1H3,(H,39,46)	QZLHZWMMVOQOTK-UHFFFAOYSA-N	293077	US20260015358, Example 46	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		 550							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293077	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293077&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123636	381613360							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
191982	CCc1c(N2CCN(C(=O)c3ncc[nH]c3=O)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C30H29ClF3N9O5/c1-2-21-24(40-9-11-41(12-10-40)27(46)23-26(45)36-8-7-35-23)28(47)43-29(38-25(39-43)17-5-13-48-14-6-17)42(21)16-22(44)37-20-4-3-18(15-19(20)31)30(32,33)34/h3-5,7-8,15H,2,6,9-14,16H2,1H3,(H,36,45)(H,37,44)	HXMRZHQYOMKATE-UHFFFAOYSA-N	293078	US20260015358, Example 47	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293078	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293078&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123578	381613361							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
191983	CCc1c(N2CCN(C(=O)c3n[nH]c(=O)cc3O)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C30H29ClF3N9O6/c1-2-20-25(40-7-9-41(10-8-40)27(47)24-21(44)14-22(45)37-38-24)28(48)43-29(36-26(39-43)16-5-11-49-12-6-16)42(20)15-23(46)35-19-4-3-17(13-18(19)31)30(32,33)34/h3-5,13-14H,2,6-12,15H2,1H3,(H,35,46)(H2,37,44,45)	LIFJKIPIJQOZDJ-UHFFFAOYSA-N	293079	US20260015358, Example 48	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293079	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293079&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123341	381613362							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
191984	CCc1c(N2CCN(C(=O)c3cnc4scnc4c3O)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C32H29ClF3N9O5S/c1-2-22-25(42-7-9-43(10-8-42)29(48)19-14-37-28-24(26(19)47)38-16-51-28)30(49)45-31(40-27(41-45)17-5-11-50-12-6-17)44(22)15-23(46)39-21-4-3-18(13-20(21)33)32(34,35)36/h3-5,13-14,16H,2,6-12,15H2,1H3,(H,37,47)(H,39,46)	PGMPFEALTSYFNO-UHFFFAOYSA-N	293080	US20260015358, Example 49	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293080	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293080&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123104	381613363							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
191985	CCc1c(N2CCN(C(=O)c3c[nH]c(=O)[nH]c3=O)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C30H29ClF3N9O6/c1-2-21-23(40-7-9-41(10-8-40)26(46)18-14-35-28(48)38-25(18)45)27(47)43-29(37-24(39-43)16-5-11-49-12-6-16)42(21)15-22(44)36-20-4-3-17(13-19(20)31)30(32,33)34/h3-5,13-14H,2,6-12,15H2,1H3,(H,36,44)(H2,35,38,45,48)	DNELBSNFBDSYPQ-UHFFFAOYSA-N	293081	US20260015358, Example 50	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293081	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293081&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123438	381613364							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
191986	CCOC(=O)c1cnc2oc(C(=O)N3CCN(c4c(CC)n(CC(=O)Nc5ccc(C(F)(F)F)cc5Cl)c5nc(C6=CCOCC6)nn5c4=O)CC3)cc2c1O	InChI=1S/C36H34ClF3N8O8/c1-3-25-28(45-9-11-46(12-10-45)32(51)26-16-21-29(50)22(34(53)55-4-2)17-41-31(21)56-26)33(52)48-35(43-30(44-48)19-7-13-54-14-8-19)47(25)18-27(49)42-24-6-5-20(15-23(24)37)36(38,39)40/h5-7,15-17H,3-4,8-14,18H2,1-2H3,(H,41,50)(H,42,49)	QNQSUBBITPGPDE-UHFFFAOYSA-N	293082	US20260015358, Example 53	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293082	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293082&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123299	381613365							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
191987	CCc1c(N2CCN(C(=O)c3nccn(C)c3=O)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C31H31ClF3N9O5/c1-3-22-25(41-10-12-42(13-11-41)28(47)24-27(46)40(2)9-8-36-24)29(48)44-30(38-26(39-44)18-6-14-49-15-7-18)43(22)17-23(45)37-21-5-4-19(16-20(21)32)31(33,34)35/h4-6,8-9,16H,3,7,10-15,17H2,1-2H3,(H,37,45)	IFUIHRLWBLCPOH-UHFFFAOYSA-N	293095	US20260015358, Example 54	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		 550							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293095	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293095&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123835	381613378							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
191988	CCc1c(N2CCN(C(=O)c3cnc4sccc4c3O)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C33H30ClF3N8O5S/c1-2-24-26(42-8-10-43(11-9-42)30(48)21-16-38-29-20(27(21)47)7-14-51-29)31(49)45-32(40-28(41-45)18-5-12-50-13-6-18)44(24)17-25(46)39-23-4-3-19(15-22(23)34)33(35,36)37/h3-5,7,14-16H,2,6,8-13,17H2,1H3,(H,38,47)(H,39,46)	KDHSCTDPVICDMO-UHFFFAOYSA-N	293096	US20260015358, Example 55	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293096	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293096&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123179	381613379							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
191989	CCc1c(N2CCN(C(=O)c3nnc(C)[nH]c3=O)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C30H30ClF3N10O5/c1-3-21-24(41-8-10-42(11-9-41)27(47)23-26(46)35-16(2)38-39-23)28(48)44-29(37-25(40-44)17-6-12-49-13-7-17)43(21)15-22(45)36-20-5-4-18(14-19(20)31)30(32,33)34/h4-6,14H,3,7-13,15H2,1-2H3,(H,36,45)(H,35,38,46)	ZTWXKYRLHTXJQB-UHFFFAOYSA-N	293097	US20260015358, Example 56	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293097	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293097&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123537	381613380							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
191990	CCc1c(N2CCN(C(=O)c3cnc4[nH]cnc4c3O)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C32H30ClF3N10O5/c1-2-22-25(43-7-9-44(10-8-43)29(49)19-14-37-28-24(26(19)48)38-16-39-28)30(50)46-31(41-27(42-46)17-5-11-51-12-6-17)45(22)15-23(47)40-21-4-3-18(13-20(21)33)32(34,35)36/h3-5,13-14,16H,2,6-12,15H2,1H3,(H,40,47)(H2,37,38,39,48)	FCJVYFAOOWKYAF-UHFFFAOYSA-N	293098	US20260015358, Example 57	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293098	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293098&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124122934	381613381							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
191991	CCc1c(N2CCN(C(=O)c3nn(C)c(=O)[nH]c3=O)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C30H30ClF3N10O6/c1-3-20-23(41-8-10-42(11-9-41)26(47)22-25(46)37-29(49)40(2)38-22)27(48)44-28(36-24(39-44)16-6-12-50-13-7-16)43(20)15-21(45)35-19-5-4-17(14-18(19)31)30(32,33)34/h4-6,14H,3,7-13,15H2,1-2H3,(H,35,45)(H,37,46,49)	FIUFWNPIIXFFGH-UHFFFAOYSA-N	293099	US20260015358, Example 58	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293099	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293099&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123376	381613382							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
191992	CCc1c(N2CCN(C(=O)c3cn(C)c(=O)[nH]c3=O)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C31H31ClF3N9O6/c1-3-22-24(41-8-10-42(11-9-41)27(47)19-15-40(2)30(49)38-26(19)46)28(48)44-29(37-25(39-44)17-6-12-50-13-7-17)43(22)16-23(45)36-21-5-4-18(14-20(21)32)31(33,34)35/h4-6,14-15H,3,7-13,16H2,1-2H3,(H,36,45)(H,38,46,49)	HCWCXAFASARDCF-UHFFFAOYSA-N	293100	US20260015358, Example 59	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		 550							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293100	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293100&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123741	381613383							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
191993	CCc1c(N2CCN(C(=O)c3cccc(C)c3O)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C33H33ClF3N7O5/c1-3-25-27(41-11-13-42(14-12-41)30(47)22-6-4-5-19(2)28(22)46)31(48)44-32(39-29(40-44)20-9-15-49-16-10-20)43(25)18-26(45)38-24-8-7-21(17-23(24)34)33(35,36)37/h4-9,17,46H,3,10-16,18H2,1-2H3,(H,38,45)	XXXMNEFXNHIQLB-UHFFFAOYSA-N	293101	US20260015358, Example 60	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		 550							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293101	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293101&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123702	381613384							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
191994	CCc1c(N2CCN(C(=O)c3nccc4cc[nH]c34)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C33H31ClF3N9O4/c1-2-24-28(43-11-13-44(14-12-43)30(48)27-26-19(5-9-38-26)6-10-39-27)31(49)46-32(41-29(42-46)20-7-15-50-16-8-20)45(24)18-25(47)40-23-4-3-21(17-22(23)34)33(35,36)37/h3-7,9-10,17,38H,2,8,11-16,18H2,1H3,(H,40,47)	QETBGSFGFIEBFV-UHFFFAOYSA-N	770824	2-(6-(4-(1H-pyrrolo[2,3-c]pyridine-7-carbonyl)piperazin-1-yl)-2-(3,6-dihydro-2H-pyran-4-yl)-5-ethyl-7-oxo-[1,2,4]triazolo[1,5-a]pyrimidin-4(7H)-yl)-N-(2-chloro-4-(trifluoromethyl)phenyl)acetamide::WO2025049746, Example 45::US20260015358, Example 61	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=770824	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=770824&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			176222182	522823369							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
191995	CCc1c(N2CCN(C(=O)c3nccc4nc[nH]c34)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C32H30ClF3N10O4/c1-2-23-27(43-9-11-44(12-10-43)29(48)26-25-22(5-8-37-26)38-17-39-25)30(49)46-31(41-28(42-46)18-6-13-50-14-7-18)45(23)16-24(47)40-21-4-3-19(15-20(21)33)32(34,35)36/h3-6,8,15,17H,2,7,9-14,16H2,1H3,(H,38,39)(H,40,47)	XGWTUMXGRGKCCS-UHFFFAOYSA-N	770821	2-(6-(4-(3H-imidazo[4,5-c]pyridine-4-carbonyl)piperazin-1-yl)-2-(3,6-dihydro-2H-pyran-4-yl)-5-ethyl-7-oxo-[1,2,4]triazolo[1,5-a]pyrimidin-4(7H)-yl)-N-(2-chloro-4-(trifluoromethyl)phenyl)acetamide::WO2025049746, Example 42::US20260015358, Example 62	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=770821	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=770821&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			176222231	522823366							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
191996	CCc1c(N2CCN(C(=O)c3c[nH][nH]c3=O)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C29H29ClF3N9O5/c1-2-21-23(39-7-9-40(10-8-39)26(45)18-14-34-37-25(18)44)27(46)42-28(36-24(38-42)16-5-11-47-12-6-16)41(21)15-22(43)35-20-4-3-17(13-19(20)30)29(31,32)33/h3-5,13-14H,2,6-12,15H2,1H3,(H,35,43)(H2,34,37,44)	UDEMQAJBVLEZLD-UHFFFAOYSA-N	293104	US20260015358, Example 63	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293104	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293104&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123334	381613387							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
191997	CCc1c(N2CCN(C(=O)c3cn(C)[nH]c3=O)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C30H31ClF3N9O5/c1-3-22-24(40-8-10-41(11-9-40)27(46)19-15-39(2)38-26(19)45)28(47)43-29(36-25(37-43)17-6-12-48-13-7-17)42(22)16-23(44)35-21-5-4-18(14-20(21)31)30(32,33)34/h4-6,14-15H,3,7-13,16H2,1-2H3,(H,35,44)(H,38,45)	STJHFRCUTYDRNN-UHFFFAOYSA-N	293105	US20260015358, Example 64	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		 550							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293105	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293105&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123260	381613388							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
191998	CCc1c(N2CCN(C(=O)c3ccc[nH]c3=O)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C31H30ClF3N8O5/c1-2-23-25(40-10-12-41(13-11-40)28(46)20-4-3-9-36-27(20)45)29(47)43-30(38-26(39-43)18-7-14-48-15-8-18)42(23)17-24(44)37-22-6-5-19(16-21(22)32)31(33,34)35/h3-7,9,16H,2,8,10-15,17H2,1H3,(H,36,45)(H,37,44)	KBZFXJRCUWVERT-UHFFFAOYSA-N	293106	US20260015358, Example 65	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		 550							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293106	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293106&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124129579	381613389							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
191999	CCc1c(N2CCN(C(=O)C3CCC(=O)N3)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C30H32ClF3N8O5/c1-2-22-25(39-9-11-40(12-10-39)27(45)21-5-6-23(43)36-21)28(46)42-29(37-26(38-42)17-7-13-47-14-8-17)41(22)16-24(44)35-20-4-3-18(15-19(20)31)30(32,33)34/h3-4,7,15,21H,2,5-6,8-14,16H2,1H3,(H,35,44)(H,36,43)	SSXJXYFBRCPOBQ-UHFFFAOYSA-N	293107	US20260015358, Example 66	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		>1000							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293107	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293107&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123004	381613390							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192000	CCc6c(N3CCN(C(=O)c1nccc2[nH]ccc12)CC3)c(=O)n5nc(C4=CCOCC4)nc5n6CC(=O)Nc7ccc(Cl)cc7C(F)(F)F	InChI=1S/C33H31ClF3N9O4/c1-2-25-28(43-11-13-44(14-12-43)30(48)27-21-5-9-38-23(21)6-10-39-27)31(49)46-32(41-29(42-46)19-7-15-50-16-8-19)45(25)18-26(47)40-24-4-3-20(34)17-22(24)33(35,36)37/h3-7,9-10,17,38H,2,8,11-16,18H2,1H3,(H,40,47)	OOVNNLHEXNLLLE-UHFFFAOYSA-N	293108	US20260015358, Example 67	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293108	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293108&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123467	381613391							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192001	CCc6c(N3CCN(C(=O)c1ccnc2cc[nH]c12)CC3)c(=O)n5nc(C4=CCOCC4)nc5n6CC(=O)Nc7ccc(Cl)cc7C(F)(F)F	InChI=1S/C33H31ClF3N9O4/c1-2-25-28(43-11-13-44(14-12-43)30(48)21-5-9-38-24-6-10-39-27(21)24)31(49)46-32(41-29(42-46)19-7-15-50-16-8-19)45(25)18-26(47)40-23-4-3-20(34)17-22(23)33(35,36)37/h3-7,9-10,17,39H,2,8,11-16,18H2,1H3,(H,40,47)	NMXHQPQQBTZKDJ-UHFFFAOYSA-N	293109	US20260015358, Example 68	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		 550							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293109	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293109&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123580	381613392							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192002	CCc6c(N3CCN(C(=O)c1ncnc2[nH]ccc12)CC3)c(=O)n5nc(C4=CCOCC4)nc5n6CC(=O)Nc7ccc(Cl)cc7C(F)(F)F	InChI=1S/C32H30ClF3N10O4/c1-2-23-26(43-9-11-44(12-10-43)29(48)25-20-5-8-37-28(20)39-17-38-25)30(49)46-31(41-27(42-46)18-6-13-50-14-7-18)45(23)16-24(47)40-22-4-3-19(33)15-21(22)32(34,35)36/h3-6,8,15,17H,2,7,9-14,16H2,1H3,(H,40,47)(H,37,38,39)	NULFIOLZQMTDRF-UHFFFAOYSA-N	293110	US20260015358, Example 69	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		 550							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293110	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293110&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123256	381613393							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192003	CCc5c(N2CCN(C(=O)c1cnc(C(F)(F)F)[nH]1)CC2)c(=O)n4nc(C3=CCOCC3)nc4n5CC(=O)Nc6ccc(Cl)cc6C(F)(F)F	InChI=1S/C30H28ClF6N9O4/c1-2-21-23(43-7-9-44(10-8-43)25(48)20-14-38-27(40-20)30(35,36)37)26(49)46-28(41-24(42-46)16-5-11-50-12-6-16)45(21)15-22(47)39-19-4-3-17(31)13-18(19)29(32,33)34/h3-5,13-14H,2,6-12,15H2,1H3,(H,38,40)(H,39,47)	BPCKKCVNZFDWRF-UHFFFAOYSA-N	293111	US20260015358, Example 70	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		 550							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293111	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293111&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124122878	381613394							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192004	CCc1c(N2CCN(C(=O)c3cc4ccsc4[nH]c3=O)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C33H30ClF3N8O5S/c1-2-24-26(42-8-10-43(11-9-42)30(48)21-15-19-7-14-51-29(19)40-28(21)47)31(49)45-32(39-27(41-45)18-5-12-50-13-6-18)44(24)17-25(46)38-23-4-3-20(16-22(23)34)33(35,36)37/h3-5,7,14-16H,2,6,8-13,17H2,1H3,(H,38,46)(H,40,47)	YUIMKYZETHHSLX-UHFFFAOYSA-N	293112	US20260015358, Example 71	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293112	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293112&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123270	381613395							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192005	CCc1c(N2CCN(C(=O)c3ccn4nc(C)cc4c3O)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C34H33ClF3N9O5/c1-3-25-28(43-10-12-44(13-11-43)31(50)22-6-9-46-26(29(22)49)16-19(2)41-46)32(51)47-33(40-30(42-47)20-7-14-52-15-8-20)45(25)18-27(48)39-24-5-4-21(17-23(24)35)34(36,37)38/h4-7,9,16-17,49H,3,8,10-15,18H2,1-2H3,(H,39,48)	YQDNREZKDXBPCC-UHFFFAOYSA-N	293113	US20260015358, Example 72	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293113	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293113&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123959	381613396							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192006	CCc5c(N2CCN(C(=O)c1n[nH]c(=O)n(C)c1=O)CC2)c(=O)n4nc(C3=CCOCC3)nc4n5CC(=O)Nc6ccc(Cl)cc6C(F)(F)F	InChI=1S/C30H30ClF3N10O6/c1-3-20-23(41-8-10-42(11-9-41)26(47)22-25(46)40(2)29(49)38-37-22)27(48)44-28(36-24(39-44)16-6-12-50-13-7-16)43(20)15-21(45)35-19-5-4-17(31)14-18(19)30(32,33)34/h4-6,14H,3,7-13,15H2,1-2H3,(H,35,45)(H,38,49)	AIRYJQRMWVDOIT-UHFFFAOYSA-N	293114	US20260015358, Example 73	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293114	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293114&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124122968	381613397							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192007	CCc1c(N2CCN(C(=O)c3sc4cnccc4c3O)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C33H30ClF3N8O5S/c1-2-23-26(42-9-11-43(12-10-42)31(49)28-27(47)20-5-8-38-16-24(20)51-28)30(48)45-32(40-29(41-45)18-6-13-50-14-7-18)44(23)17-25(46)39-22-4-3-19(15-21(22)34)33(35,36)37/h3-6,8,15-16,47H,2,7,9-14,17H2,1H3,(H,39,46)	ZJXUXTDHZXGRQO-UHFFFAOYSA-N	293115	US20260015358, Example 74	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293115	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293115&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123828	381613398							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192008	CCc1c(N2CCN(C(=O)c3nc4cnccn4c3O)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C32H30ClF3N10O5/c1-2-22-26(42-9-11-43(12-10-42)28(48)25-29(49)44-8-7-37-16-23(44)39-25)30(50)46-31(40-27(41-46)18-5-13-51-14-6-18)45(22)17-24(47)38-21-4-3-19(15-20(21)33)32(34,35)36/h3-5,7-8,15-16,49H,2,6,9-14,17H2,1H3,(H,38,47)	CSICPYLXWBTCII-UHFFFAOYSA-N	293116	US20260015358, Example 75	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		 550							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293116	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293116&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123919	381613399							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192009	CCc1c(N2CCN(C(=O)c3n[nH]cc(C)c3=O)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C31H31ClF3N9O5/c1-3-22-25(41-8-10-42(11-9-41)28(47)24-26(46)17(2)15-36-39-24)29(48)44-30(38-27(40-44)18-6-12-49-13-7-18)43(22)16-23(45)37-21-5-4-19(14-20(21)32)31(33,34)35/h4-6,14-15H,3,7-13,16H2,1-2H3,(H,36,46)(H,37,45)	LVVRRWIUBFUWCV-UHFFFAOYSA-N	293117	US20260015358, Example 76	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		 550							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293117	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293117&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123358	381613400							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192010	CCc1c(N2CCN(C(=O)c3cnc4c(ccn4C)c3O)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C34H33ClF3N9O5/c1-3-25-27(44-10-12-45(13-11-44)31(50)22-17-39-30-21(28(22)49)6-9-43(30)2)32(51)47-33(41-29(42-47)19-7-14-52-15-8-19)46(25)18-26(48)40-24-5-4-20(16-23(24)35)34(36,37)38/h4-7,9,16-17H,3,8,10-15,18H2,1-2H3,(H,39,49)(H,40,48)	UAYLIRRAJWRYOF-UHFFFAOYSA-N	293118	US20260015358, Example 77	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293118	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293118&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123046	381613401							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192011	CCc1c(N2CCN(C(=O)c3cccc(=O)[nH]3)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C31H30ClF3N8O5/c1-2-23-26(40-10-12-41(13-11-40)28(46)22-4-3-5-24(44)37-22)29(47)43-30(38-27(39-43)18-8-14-48-15-9-18)42(23)17-25(45)36-21-7-6-19(16-20(21)32)31(33,34)35/h3-8,16H,2,9-15,17H2,1H3,(H,36,45)(H,37,44)	BUJJXRPWBLJWMK-UHFFFAOYSA-N	293119	US20260015358, Example 78	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293119	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293119&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123905	381613402							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192012	CCc1c(N2CCN(C(=O)c3ccnc(=O)[nH]3)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C30H29ClF3N9O5/c1-2-22-24(40-9-11-41(12-10-40)26(45)21-5-8-35-28(47)37-21)27(46)43-29(38-25(39-43)17-6-13-48-14-7-17)42(22)16-23(44)36-20-4-3-18(15-19(20)31)30(32,33)34/h3-6,8,15H,2,7,9-14,16H2,1H3,(H,36,44)(H,35,37,47)	WGQWNKSWSHFHEH-UHFFFAOYSA-N	293120	US20260015358, Example 79	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		 550							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293120	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293120&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123931	381613403							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192013	CCc1c(N2CCN(C(=O)c3cc4ccn(C)c4cc3O)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C35H34ClF3N8O5/c1-3-26-30(44-10-12-45(13-11-44)32(50)23-16-21-6-9-43(2)27(21)18-28(23)48)33(51)47-34(41-31(42-47)20-7-14-52-15-8-20)46(26)19-29(49)40-25-5-4-22(17-24(25)36)35(37,38)39/h4-7,9,16-18,48H,3,8,10-15,19H2,1-2H3,(H,40,49)	BPDZEUASUOAWBJ-UHFFFAOYSA-N	293121	US20260015358, Example 80	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		 550							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293121	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293121&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123872	381613404							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192014	CCc1c(N2CCN(C(=O)c3cnc4ncsc4c3O)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C32H29ClF3N9O5S/c1-2-22-24(42-7-9-43(10-8-42)29(48)19-14-37-28-26(25(19)47)51-16-38-28)30(49)45-31(40-27(41-45)17-5-11-50-12-6-17)44(22)15-23(46)39-21-4-3-18(13-20(21)33)32(34,35)36/h3-5,13-14,16H,2,6-12,15H2,1H3,(H,37,47)(H,39,46)	LNPHFCHTANZCNC-UHFFFAOYSA-N	293122	US20260015358, Example 81	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293122	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293122&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123687	381613405							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192015	CCc1c(N2CCN(C(=O)c3nnccc3O)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C30H29ClF3N9O5/c1-2-21-25(40-9-11-41(12-10-40)27(46)24-22(44)5-8-35-38-24)28(47)43-29(37-26(39-43)17-6-13-48-14-7-17)42(21)16-23(45)36-20-4-3-18(15-19(20)31)30(32,33)34/h3-6,8,15H,2,7,9-14,16H2,1H3,(H,35,44)(H,36,45)	ULYKHPBTPDGCOD-UHFFFAOYSA-N	293123	US20260015358, Example 82	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293123	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293123&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123520	381613406							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192016	CCc1c(N2CCN(C(=O)c3nnc(Cl)cc3O)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C30H28Cl2F3N9O5/c1-2-20-25(41-7-9-42(10-8-41)27(47)24-21(45)14-22(32)38-39-24)28(48)44-29(37-26(40-44)16-5-11-49-12-6-16)43(20)15-23(46)36-19-4-3-17(13-18(19)31)30(33,34)35/h3-5,13-14H,2,6-12,15H2,1H3,(H,36,46)(H,38,45)	USWVWHIWKPVVBZ-UHFFFAOYSA-N	293124	US20260015358, Example 83	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293124	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293124&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123545	381613407							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192017	CCc1c(N2CCN(C(=O)c3cnn4cccc4c3O)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C33H31ClF3N9O5/c1-2-24-27(42-10-12-43(13-11-42)30(49)21-17-38-45-9-3-4-25(45)28(21)48)31(50)46-32(40-29(41-46)19-7-14-51-15-8-19)44(24)18-26(47)39-23-6-5-20(16-22(23)34)33(35,36)37/h3-7,9,16-17,48H,2,8,10-15,18H2,1H3,(H,39,47)	HTUNYTRRZMFJAC-UHFFFAOYSA-N	293125	US20260015358, Example 84	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293125	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293125&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123681	381613408							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192018	CCc1c(N2CCN(C(=O)c3nn4ccnc4cc3O)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C32H30ClF3N10O5/c1-2-22-27(42-9-11-43(12-10-42)29(49)26-23(47)16-24-37-7-8-45(24)40-26)30(50)46-31(39-28(41-46)18-5-13-51-14-6-18)44(22)17-25(48)38-21-4-3-19(15-20(21)33)32(34,35)36/h3-5,7-8,15-16,47H,2,6,9-14,17H2,1H3,(H,38,48)	VRRVBIWGEUAMPN-UHFFFAOYSA-N	293126	US20260015358, Example 85	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293126	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293126&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124122866	381613409							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192019	CCc1c(N2CCN(C(=O)c3cc4ncncc4[nH]3)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C32H30ClF3N10O4/c1-2-25-27(43-7-9-44(10-8-43)29(48)23-14-22-24(39-23)15-37-17-38-22)30(49)46-31(41-28(42-46)18-5-11-50-12-6-18)45(25)16-26(47)40-21-4-3-19(13-20(21)33)32(34,35)36/h3-5,13-15,17,39H,2,6-12,16H2,1H3,(H,40,47)	WHPAIHMMJXYQFA-UHFFFAOYSA-N	293127	US20260015358, Example 86	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		 550							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293127	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293127&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123696	381613410							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192020	CCc1c(N2CCN(C(=O)c3sc4ncccc4c3O)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C33H30ClF3N8O5S/c1-2-23-25(42-10-12-43(13-11-42)31(49)27-26(47)20-4-3-9-38-29(20)51-27)30(48)45-32(40-28(41-45)18-7-14-50-15-8-18)44(23)17-24(46)39-22-6-5-19(16-21(22)34)33(35,36)37/h3-7,9,16,47H,2,8,10-15,17H2,1H3,(H,39,46)	VUEPGWJGVIAXGG-UHFFFAOYSA-N	293128	US20260015358, Example 87	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293128	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293128&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123803	381613411							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192021	CCc1c(N2CCN(C(=O)c3cc4c(O)ccnc4o3)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C33H30ClF3N8O6/c1-2-23-27(42-9-11-43(12-10-42)30(48)25-16-20-24(46)5-8-38-29(20)51-25)31(49)45-32(40-28(41-45)18-6-13-50-14-7-18)44(23)17-26(47)39-22-4-3-19(15-21(22)34)33(35,36)37/h3-6,8,15-16H,2,7,9-14,17H2,1H3,(H,38,46)(H,39,47)	BOPZEUZAIFRICD-UHFFFAOYSA-N	293129	US20260015358, Example 88	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293129	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293129&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123266	381613412							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192022	CCc1c(N2CCN(C(=O)C(N)=O)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C27H28ClF3N8O5/c1-2-19-21(36-7-9-37(10-8-36)25(43)22(32)41)24(42)39-26(34-23(35-39)15-5-11-44-12-6-15)38(19)14-20(40)33-18-4-3-16(13-17(18)28)27(29,30)31/h3-5,13H,2,6-12,14H2,1H3,(H2,32,41)(H,33,40)	PJEOUROIABUTEL-UHFFFAOYSA-N	293130	US20260015358, Example 89	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293130	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293130&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123120	381613413							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192023	CCc1c(N2CCN(C(=O)c3cccc4cn[nH]c34)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C33H31ClF3N9O4/c1-2-25-28(43-10-12-44(13-11-43)30(48)22-5-3-4-20-17-38-41-27(20)22)31(49)46-32(40-29(42-46)19-8-14-50-15-9-19)45(25)18-26(47)39-24-7-6-21(16-23(24)34)33(35,36)37/h3-8,16-17H,2,9-15,18H2,1H3,(H,38,41)(H,39,47)	LXUYFENJVUUPCL-UHFFFAOYSA-N	293131	US20260015358, Example 90	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293131	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293131&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123899	381613414							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192024	CCc1c(N2CCN(C(=O)c3cccc4cc[nH]c34)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C34H32ClF3N8O4/c1-2-26-29(43-12-14-44(15-13-43)31(48)23-5-3-4-20-8-11-39-28(20)23)32(49)46-33(41-30(42-46)21-9-16-50-17-10-21)45(26)19-27(47)40-25-7-6-22(18-24(25)35)34(36,37)38/h3-9,11,18,39H,2,10,12-17,19H2,1H3,(H,40,47)	OCBGOQRODHATGX-UHFFFAOYSA-N	293132	US20260015358, Example 91	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293132	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293132&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123055	381613415							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192025	CCc1c(N2CCN(C(=O)c3cnc4cc(C)cn4c3O)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C34H33ClF3N9O5/c1-3-25-28(43-8-10-44(11-9-43)30(49)22-16-39-26-14-19(2)17-46(26)31(22)50)32(51)47-33(41-29(42-47)20-6-12-52-13-7-20)45(25)18-27(48)40-24-5-4-21(15-23(24)35)34(36,37)38/h4-6,14-17,50H,3,7-13,18H2,1-2H3,(H,40,48)	UGBZJAKWFHCTLV-UHFFFAOYSA-N	293133	US20260015358, Example 92	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293133	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293133&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123807	381613416							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192026	CCc1c(N2CCN(C(=O)CNC(=O)c3ccccc3)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C34H34ClF3N8O5/c1-2-26-29(44-14-12-43(13-15-44)28(48)19-39-31(49)22-6-4-3-5-7-22)32(50)46-33(41-30(42-46)21-10-16-51-17-11-21)45(26)20-27(47)40-25-9-8-23(18-24(25)35)34(36,37)38/h3-10,18H,2,11-17,19-20H2,1H3,(H,39,49)(H,40,47)	ZABJLHWVESRILV-UHFFFAOYSA-N	293134	US20260015358, Example 93	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293134	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293134&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123238	381613417							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192027	CCCC(=O)NCC(=O)N1CCN(c2c(CC)n(CC(=O)Nc3ccc(C(F)(F)F)cc3Cl)c3nc(C4=CCOCC4)nn3c2=O)CC1	InChI=1S/C31H36ClF3N8O5/c1-3-5-24(44)36-17-26(46)40-10-12-41(13-11-40)27-23(4-2)42(18-25(45)37-22-7-6-20(16-21(22)32)31(33,34)35)30-38-28(39-43(30)29(27)47)19-8-14-48-15-9-19/h6-8,16H,3-5,9-15,17-18H2,1-2H3,(H,36,44)(H,37,45)	LCJDUBCXICNSCA-UHFFFAOYSA-N	293135	US20260015358, Example 94	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293135	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293135&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123161	381613418							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192028	CCc1c(N2CCN(C(=O)CNC(=O)c3ccccn3)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C33H33ClF3N9O5/c1-2-25-28(44-13-11-43(12-14-44)27(48)18-39-30(49)24-5-3-4-10-38-24)31(50)46-32(41-29(42-46)20-8-15-51-16-9-20)45(25)19-26(47)40-23-7-6-21(17-22(23)34)33(35,36)37/h3-8,10,17H,2,9,11-16,18-19H2,1H3,(H,39,49)(H,40,47)	BIYOBMLUSQEUHJ-UHFFFAOYSA-N	293136	US20260015358, Example 95	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293136	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293136&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124122886	381613419							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192029	CCc1c(N2CCN(C(=O)CNC(=O)c3ccncc3)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C33H33ClF3N9O5/c1-2-25-28(44-13-11-43(12-14-44)27(48)18-39-30(49)21-5-9-38-10-6-21)31(50)46-32(41-29(42-46)20-7-15-51-16-8-20)45(25)19-26(47)40-24-4-3-22(17-23(24)34)33(35,36)37/h3-7,9-10,17H,2,8,11-16,18-19H2,1H3,(H,39,49)(H,40,47)	XRCWZJBTTSCOBQ-UHFFFAOYSA-N	293137	US20260015358, Example 96	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293137	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293137&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123922	381613420							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192030	CCc1c(N2CCN(C(=O)CNC(=O)c3ccccc3F)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C34H33ClF4N8O5/c1-2-26-29(45-13-11-44(12-14-45)28(49)18-40-31(50)22-5-3-4-6-24(22)36)32(51)47-33(42-30(43-47)20-9-15-52-16-10-20)46(26)19-27(48)41-25-8-7-21(17-23(25)35)34(37,38)39/h3-9,17H,2,10-16,18-19H2,1H3,(H,40,50)(H,41,48)	UFQOSJYTLODSBS-UHFFFAOYSA-N	293138	US20260015358, Example 97	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293138	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293138&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123697	381613421							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192031	CCc1c(N2CCN(C(=O)CNC(=O)c3ccc(F)cc3)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C34H33ClF4N8O5/c1-2-26-29(45-13-11-44(12-14-45)28(49)18-40-31(50)21-3-6-23(36)7-4-21)32(51)47-33(42-30(43-47)20-9-15-52-16-10-20)46(26)19-27(48)41-25-8-5-22(17-24(25)35)34(37,38)39/h3-9,17H,2,10-16,18-19H2,1H3,(H,40,50)(H,41,48)	SRPUBOLDVZBTMX-UHFFFAOYSA-N	293139	US20260015358, Example 98	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293139	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293139&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123677	381613422							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192032	CCc1c(N2CCN(C(=O)CNC(=O)c3cccc(F)c3)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C34H33ClF4N8O5/c1-2-26-29(45-12-10-44(11-13-45)28(49)18-40-31(50)21-4-3-5-23(36)16-21)32(51)47-33(42-30(43-47)20-8-14-52-15-9-20)46(26)19-27(48)41-25-7-6-22(17-24(25)35)34(37,38)39/h3-8,16-17H,2,9-15,18-19H2,1H3,(H,40,50)(H,41,48)	PKORXTXNJBRIPN-UHFFFAOYSA-N	293140	US20260015358, Example 99	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293140	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293140&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123764	381613423							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192033	CCc1c(N2CCN(C(=O)CNC(=O)c3nccs3)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C31H31ClF3N9O5S/c1-2-22-25(42-10-8-41(9-11-42)24(46)16-37-27(47)28-36-7-14-50-28)29(48)44-30(39-26(40-44)18-5-12-49-13-6-18)43(22)17-23(45)38-21-4-3-19(15-20(21)32)31(33,34)35/h3-5,7,14-15H,2,6,8-13,16-17H2,1H3,(H,37,47)(H,38,45)	DSQPIBBDSTXOPQ-UHFFFAOYSA-N	293141	US20260015358, Example 100	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293141	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293141&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123350	381613424							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192034	CCc1c(N2CCN(C(=O)CNC(=O)c3ccn[nH]3)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C31H32ClF3N10O5/c1-2-23-26(43-11-9-42(10-12-43)25(47)16-36-28(48)22-5-8-37-40-22)29(49)45-30(39-27(41-45)18-6-13-50-14-7-18)44(23)17-24(46)38-21-4-3-19(15-20(21)32)31(33,34)35/h3-6,8,15H,2,7,9-14,16-17H2,1H3,(H,36,48)(H,37,40)(H,38,46)	VOJYUSJXEGTSLT-UHFFFAOYSA-N	293142	US20260015358, Example 101	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293142	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293142&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124122850	381613425							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192035	CCc1c(N2CCN(C(=O)CNC(=O)c3ccn(C)n3)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C32H34ClF3N10O5/c1-3-24-27(44-12-10-43(11-13-44)26(48)17-37-29(49)23-6-9-42(2)40-23)30(50)46-31(39-28(41-46)19-7-14-51-15-8-19)45(24)18-25(47)38-22-5-4-20(16-21(22)33)32(34,35)36/h4-7,9,16H,3,8,10-15,17-18H2,1-2H3,(H,37,49)(H,38,47)	XDUPUASCQWAOGN-UHFFFAOYSA-N	293143	US20260015358, Example 102	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293143	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293143&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123862	381613426							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192036	CCc1c(N2CCN(C(=O)CNC(=O)c3cnn(C)c3)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C32H34ClF3N10O5/c1-3-24-27(44-10-8-43(9-11-44)26(48)16-37-29(49)20-15-38-42(2)17-20)30(50)46-31(40-28(41-46)19-6-12-51-13-7-19)45(24)18-25(47)39-23-5-4-21(14-22(23)33)32(34,35)36/h4-6,14-15,17H,3,7-13,16,18H2,1-2H3,(H,37,49)(H,39,47)	UQRYBOCDWQXTGO-UHFFFAOYSA-N	293144	US20260015358, Example 103	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293144	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293144&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123451	381613427							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192037	CCc1c(N2CCN(C(=O)CNC(=O)c3cccc(Cl)c3Cl)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C34H32Cl3F3N8O5/c1-2-25-29(46-12-10-45(11-13-46)27(50)17-41-31(51)21-4-3-5-22(35)28(21)37)32(52)48-33(43-30(44-48)19-8-14-53-15-9-19)47(25)18-26(49)42-24-7-6-20(16-23(24)36)34(38,39)40/h3-8,16H,2,9-15,17-18H2,1H3,(H,41,51)(H,42,49)	QHAFRZKOZUAXCY-UHFFFAOYSA-N	293145	US20260015358, Example 104	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		 550							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293145	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293145&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123446	381613428							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192038	CCc1c(N2CCN(C(=O)CNC(=O)c3csc(C)n3)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C32H33ClF3N9O5S/c1-3-24-27(43-10-8-42(9-11-43)26(47)15-37-29(48)23-17-51-18(2)38-23)30(49)45-31(40-28(41-45)19-6-12-50-13-7-19)44(24)16-25(46)39-22-5-4-20(14-21(22)33)32(34,35)36/h4-6,14,17H,3,7-13,15-16H2,1-2H3,(H,37,48)(H,39,46)	AWVKEUJNXINFAA-UHFFFAOYSA-N	293146	US20260015358, Example 105	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		 550							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293146	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293146&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123876	381613429							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192039	CCc1c(N2CCN(C(=O)CNC(=O)c3ncc[nH]3)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C31H32ClF3N10O5/c1-2-22-25(43-11-9-42(10-12-43)24(47)16-38-28(48)27-36-7-8-37-27)29(49)45-30(40-26(41-45)18-5-13-50-14-6-18)44(22)17-23(46)39-21-4-3-19(15-20(21)32)31(33,34)35/h3-5,7-8,15H,2,6,9-14,16-17H2,1H3,(H,36,37)(H,38,48)(H,39,46)	GLYAYCGSPGWKPA-UHFFFAOYSA-N	293147	US20260015358, Example 106	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		 550							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293147	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293147&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123473	381613430							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192040	CCc1c(N2CCN(C(=O)CNC(=O)c3cc(C)on3)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C32H33ClF3N9O6/c1-3-24-27(43-10-8-42(9-11-43)26(47)16-37-29(48)23-14-18(2)51-41-23)30(49)45-31(39-28(40-45)19-6-12-50-13-7-19)44(24)17-25(46)38-22-5-4-20(15-21(22)33)32(34,35)36/h4-6,14-15H,3,7-13,16-17H2,1-2H3,(H,37,48)(H,38,46)	MEOFOFMEEKDOGU-UHFFFAOYSA-N	293148	US20260015358, Example 107	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293148	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293148&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123201	381613431							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192041	CCc1c(N2CCN(C(=O)CNC(=O)c3c[nH][nH]c3=O)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C31H32ClF3N10O6/c1-2-22-25(43-9-7-42(8-10-43)24(47)15-36-27(48)19-14-37-40-28(19)49)29(50)45-30(39-26(41-45)17-5-11-51-12-6-17)44(22)16-23(46)38-21-4-3-18(13-20(21)32)31(33,34)35/h3-5,13-14H,2,6-12,15-16H2,1H3,(H,36,48)(H,38,46)(H2,37,40,49)	NYUDMVXROMWESL-UHFFFAOYSA-N	293149	US20260015358, Example 108	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293149	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293149&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123859	381613432							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192042	CCc1c(N2CCN(C(=O)CNC(=O)c3cnn4cccc4c3O)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1F	InChI=1S/C35H34F4N10O6/c1-2-25-29(46-12-10-45(11-13-46)28(51)18-40-32(53)22-17-41-48-9-3-4-26(48)30(22)52)33(54)49-34(43-31(44-49)20-7-14-55-15-8-20)47(25)19-27(50)42-24-6-5-21(16-23(24)36)35(37,38)39/h3-7,9,16-17,52H,2,8,10-15,18-19H2,1H3,(H,40,53)(H,42,50)	XAJVJOFLSPBSFY-UHFFFAOYSA-N	293150	US20260015358, Example 109	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293150	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293150&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123658	381613433							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192043	CCc1c(N2CCN(C(=O)CNC(=O)c3cccnc3)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C33H33ClF3N9O5/c1-2-25-28(44-12-10-43(11-13-44)27(48)18-39-30(49)21-4-3-9-38-17-21)31(50)46-32(41-29(42-46)20-7-14-51-15-8-20)45(25)19-26(47)40-24-6-5-22(16-23(24)34)33(35,36)37/h3-7,9,16-17H,2,8,10-15,18-19H2,1H3,(H,39,49)(H,40,47)	NGLTYVRAZVPSTJ-UHFFFAOYSA-N	293152	US20260015358, Example 110	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293152	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293152&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123278	381613434							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192044	CCc1c(N2CCN(C(=O)CNC(=O)c3ccccc3Cl)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C34H33Cl2F3N8O5/c1-2-26-29(45-13-11-44(12-14-45)28(49)18-40-31(50)22-5-3-4-6-23(22)35)32(51)47-33(42-30(43-47)20-9-15-52-16-10-20)46(26)19-27(48)41-25-8-7-21(17-24(25)36)34(37,38)39/h3-9,17H,2,10-16,18-19H2,1H3,(H,40,50)(H,41,48)	CHTATLARVKMKOO-UHFFFAOYSA-N	293153	US20260015358, Example 111	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293153	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293153&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123181	381613435							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192045	CCC1=C(N2CCN(C(=O)CNC(=O)c3ccccc3OC)CC2)C(=O)n2nc(C3=CCOCC3)nc2C1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C36H37ClF3N7O6/c1-3-23-25(19-29(48)42-27-9-8-22(18-26(27)37)36(38,39)40)33-43-32(21-10-16-53-17-11-21)44-47(33)35(51)31(23)46-14-12-45(13-15-46)30(49)20-41-34(50)24-6-4-5-7-28(24)52-2/h4-10,18,25H,3,11-17,19-20H2,1-2H3,(H,41,50)(H,42,48)	AVUMLHDADFZSQS-UHFFFAOYSA-N	293154	US20260015358, Example 112	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293154	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293154&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123048	381613436							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192046	CCc1c(N2CCN(C(=O)CNC(=O)c3ccccc3Br)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C34H33BrClF3N8O5/c1-2-26-29(45-13-11-44(12-14-45)28(49)18-40-31(50)22-5-3-4-6-23(22)35)32(51)47-33(42-30(43-47)20-9-15-52-16-10-20)46(26)19-27(48)41-25-8-7-21(17-24(25)36)34(37,38)39/h3-9,17H,2,10-16,18-19H2,1H3,(H,40,50)(H,41,48)	OZRWSFHPMCWKIJ-UHFFFAOYSA-N	293155	US20260015358, Example 113	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293155	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293155&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123709	381613437							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192047	CCc1c(N2CCN(C(=O)CNC(=O)c3ccnn3C)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C32H34ClF3N10O5/c1-3-23-27(44-12-10-43(11-13-44)26(48)17-37-29(49)24-6-9-38-42(24)2)30(50)46-31(40-28(41-46)19-7-14-51-15-8-19)45(23)18-25(47)39-22-5-4-20(16-21(22)33)32(34,35)36/h4-7,9,16H,3,8,10-15,17-18H2,1-2H3,(H,37,49)(H,39,47)	WIYBOKFLJAVVQZ-UHFFFAOYSA-N	293156	US20260015358, Example 114	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293156	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293156&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123085	381613438							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192048	CCc1c(N2CCN(C(=O)CNC(=O)c3cc(F)cc(F)c3)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C34H32ClF5N8O5/c1-2-26-29(46-9-7-45(8-10-46)28(50)17-41-31(51)20-13-22(36)16-23(37)14-20)32(52)48-33(43-30(44-48)19-5-11-53-12-6-19)47(26)18-27(49)42-25-4-3-21(15-24(25)35)34(38,39)40/h3-5,13-16H,2,6-12,17-18H2,1H3,(H,41,51)(H,42,49)	AAILKQVYAZLGIZ-UHFFFAOYSA-N	293157	US20260015358, Example 115	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293157	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293157&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123020	381613439							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192049	CCc1c(N2CCN(C(=O)CNC(=O)c3cccc(F)c3F)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C34H32ClF5N8O5/c1-2-25-29(46-12-10-45(11-13-46)27(50)17-41-31(51)21-4-3-5-23(36)28(21)37)32(52)48-33(43-30(44-48)19-8-14-53-15-9-19)47(25)18-26(49)42-24-7-6-20(16-22(24)35)34(38,39)40/h3-8,16H,2,9-15,17-18H2,1H3,(H,41,51)(H,42,49)	NFHGKRWRRGRUQD-UHFFFAOYSA-N	293158	US20260015358, Example 116	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293158	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293158&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123921	381613440							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192050	CCc1c(N2CCN(C(=O)CNC(=O)c3ccc(F)cc3F)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C34H32ClF5N8O5/c1-2-26-29(46-11-9-45(10-12-46)28(50)17-41-31(51)22-5-4-21(36)16-24(22)37)32(52)48-33(43-30(44-48)19-7-13-53-14-8-19)47(26)18-27(49)42-25-6-3-20(15-23(25)35)34(38,39)40/h3-7,15-16H,2,8-14,17-18H2,1H3,(H,41,51)(H,42,49)	JLWCVXBLFWFRRV-UHFFFAOYSA-N	293159	US20260015358, Example 117	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293159	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293159&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124122883	381613441							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192051	CCc1c(N2CCN(C(=O)CNC(=O)c3cc(F)ccc3F)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C34H32ClF5N8O5/c1-2-26-29(46-11-9-45(10-12-46)28(50)17-41-31(51)22-16-21(36)4-5-24(22)37)32(52)48-33(43-30(44-48)19-7-13-53-14-8-19)47(26)18-27(49)42-25-6-3-20(15-23(25)35)34(38,39)40/h3-7,15-16H,2,8-14,17-18H2,1H3,(H,41,51)(H,42,49)	YKFUXDDIPUEHQJ-UHFFFAOYSA-N	293160	US20260015358, Example 118	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293160	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293160&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124122828	381613442							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192052	CCc1c(N2CCN(C(=O)CNC(=O)c3ccc(OC)cc3)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C35H36ClF3N8O6/c1-3-27-30(45-14-12-44(13-15-45)29(49)19-40-32(50)22-4-7-24(52-2)8-5-22)33(51)47-34(42-31(43-47)21-10-16-53-17-11-21)46(27)20-28(48)41-26-9-6-23(18-25(26)36)35(37,38)39/h4-10,18H,3,11-17,19-20H2,1-2H3,(H,40,50)(H,41,48)	HYDKDLZHQNQLLN-UHFFFAOYSA-N	293161	US20260015358, Example 119	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293161	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293161&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123319	381613443							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192053	CCc1c(N2CCN(C(=O)CNC(=O)c3cnc4c(ccn4C)c3O)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C36H36ClF3N10O6/c1-3-26-29(48-12-10-47(11-13-48)28(52)18-42-33(54)23-17-41-32-22(30(23)53)6-9-46(32)2)34(55)50-35(44-31(45-50)20-7-14-56-15-8-20)49(26)19-27(51)43-25-5-4-21(16-24(25)37)36(38,39)40/h4-7,9,16-17H,3,8,10-15,18-19H2,1-2H3,(H,41,53)(H,42,54)(H,43,51)	PIJBRORVYLLWAM-UHFFFAOYSA-N	293162	US20260015358, Example 120	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		 550							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293162	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293162&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124122961	381613444							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192054	CCc1c(N2CCN(C(=O)CNC(=O)c3c[nH]cn3)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C31H32ClF3N10O5/c1-2-23-26(43-9-7-42(8-10-43)25(47)15-37-28(48)22-14-36-17-38-22)29(49)45-30(40-27(41-45)18-5-11-50-12-6-18)44(23)16-24(46)39-21-4-3-19(13-20(21)32)31(33,34)35/h3-5,13-14,17H,2,6-12,15-16H2,1H3,(H,36,38)(H,37,48)(H,39,46)	UCSOHWKQAMRIIK-UHFFFAOYSA-N	293163	US20260015358, Example 121	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293163	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293163&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123378	381613445							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192055	CCc1c(N2CCN(C(=O)CNC(=O)c3cc(C)ns3)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C32H33ClF3N9O5S/c1-3-23-27(43-10-8-42(9-11-43)26(47)16-37-29(48)24-14-18(2)41-51-24)30(49)45-31(39-28(40-45)19-6-12-50-13-7-19)44(23)17-25(46)38-22-5-4-20(15-21(22)33)32(34,35)36/h4-6,14-15H,3,7-13,16-17H2,1-2H3,(H,37,48)(H,38,46)	ZWUNDKZYYCIMLA-UHFFFAOYSA-N	293164	US20260015358, Example 122	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293164	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293164&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123793	381613446							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192056	CCc1c(N2CCN(C(=O)CNC(=O)c3ncco3)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C31H31ClF3N9O6/c1-2-22-25(42-10-8-41(9-11-42)24(46)16-37-27(47)28-36-7-14-50-28)29(48)44-30(39-26(40-44)18-5-12-49-13-6-18)43(22)17-23(45)38-21-4-3-19(15-20(21)32)31(33,34)35/h3-5,7,14-15H,2,6,8-13,16-17H2,1H3,(H,37,47)(H,38,45)	MWIKAEFXPMCDLB-UHFFFAOYSA-N	293165	US20260015358, Example 123	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293165	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293165&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124122913	381613447							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192057	CCc1c(N2CCN(C(=O)CNC(=O)c3c(F)cccc3F)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C34H32ClF5N8O5/c1-2-25-29(46-12-10-45(11-13-46)27(50)17-41-31(51)28-22(36)4-3-5-23(28)37)32(52)48-33(43-30(44-48)19-8-14-53-15-9-19)47(25)18-26(49)42-24-7-6-20(16-21(24)35)34(38,39)40/h3-8,16H,2,9-15,17-18H2,1H3,(H,41,51)(H,42,49)	WJYQSSPMDGPQSZ-UHFFFAOYSA-N	293166	US20260015358, Example 124	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293166	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293166&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123282	381613448							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192058	CCc1c(N2CCN(C(=O)CNC(=O)C3=C(Cl)CCC=C3Cl)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C34H34Cl3F3N8O5/c1-2-25-29(46-12-10-45(11-13-46)27(50)17-41-31(51)28-21(35)4-3-5-22(28)36)32(52)48-33(43-30(44-48)19-8-14-53-15-9-19)47(25)18-26(49)42-24-7-6-20(16-23(24)37)34(38,39)40/h4,6-8,16H,2-3,5,9-15,17-18H2,1H3,(H,41,51)(H,42,49)	GHRWAJZPJPXCPP-UHFFFAOYSA-N	293167	US20260015358, Example 125	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		 550							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293167	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293167&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123900	381613449							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192059	CCc1c(N2CCN(C(=O)CNC(=O)c3cc(Cl)ccc3Cl)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C34H32Cl3F3N8O5/c1-2-26-29(46-11-9-45(10-12-46)28(50)17-41-31(51)22-16-21(35)4-5-23(22)36)32(52)48-33(43-30(44-48)19-7-13-53-14-8-19)47(26)18-27(49)42-25-6-3-20(15-24(25)37)34(38,39)40/h3-7,15-16H,2,8-14,17-18H2,1H3,(H,41,51)(H,42,49)	XSQLUZCZLHIMKU-UHFFFAOYSA-N	293168	US20260015358, Example 126	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293168	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293168&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123533	381613450							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192060	CCc1c(N2CCN(C(=O)CNC(=O)c3ncc(C)s3)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C32H33ClF3N9O5S/c1-3-23-26(43-10-8-42(9-11-43)25(47)16-37-28(48)29-38-15-18(2)51-29)30(49)45-31(40-27(41-45)19-6-12-50-13-7-19)44(23)17-24(46)39-22-5-4-20(14-21(22)33)32(34,35)36/h4-6,14-15H,3,7-13,16-17H2,1-2H3,(H,37,48)(H,39,46)	IMOOCOWCWIEFED-UHFFFAOYSA-N	293169	US20260015358, Example 128	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		 550							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293169	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293169&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123337	381613451							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192061	CCc1c(N2CCN(C(=O)CNC(=O)c3cscn3)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C31H31ClF3N9O5S/c1-2-23-26(42-9-7-41(8-10-42)25(46)14-36-28(47)22-16-50-17-37-22)29(48)44-30(39-27(40-44)18-5-11-49-12-6-18)43(23)15-24(45)38-21-4-3-19(13-20(21)32)31(33,34)35/h3-5,13,16-17H,2,6-12,14-15H2,1H3,(H,36,47)(H,38,45)	OVSJTBPZYFETRS-UHFFFAOYSA-N	293170	US20260015358, Example 129	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293170	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293170&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123457	381613452							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192062	CCc1c(N2CCN(C(=O)CNC(=O)c3cc(C)no3)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C32H33ClF3N9O6/c1-3-23-27(43-10-8-42(9-11-43)26(47)16-37-29(48)24-14-18(2)41-51-24)30(49)45-31(39-28(40-45)19-6-12-50-13-7-19)44(23)17-25(46)38-22-5-4-20(15-21(22)33)32(34,35)36/h4-6,14-15H,3,7-13,16-17H2,1-2H3,(H,37,48)(H,38,46)	YGSLPCCSFGOFJN-UHFFFAOYSA-N	293171	US20260015358, Example 130	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293171	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293171&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123230	381613453							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192063	CCc1c(N2CCN(C(=O)CNC(=O)c3cnc(C)s3)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C32H33ClF3N9O5S/c1-3-23-27(43-10-8-42(9-11-43)26(47)16-38-29(48)24-15-37-18(2)51-24)30(49)45-31(40-28(41-45)19-6-12-50-13-7-19)44(23)17-25(46)39-22-5-4-20(14-21(22)33)32(34,35)36/h4-6,14-15H,3,7-13,16-17H2,1-2H3,(H,38,48)(H,39,46)	HSXDKOZOWXVHKY-UHFFFAOYSA-N	293172	US20260015358, Example 131	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		 550							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293172	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293172&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123425	381613454							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192064	CCc1c(N2CCN(C(=O)CNC(=O)c3ccc(F)c(F)c3)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C34H32ClF5N8O5/c1-2-26-29(46-11-9-45(10-12-46)28(50)17-41-31(51)20-3-5-23(36)24(37)15-20)32(52)48-33(43-30(44-48)19-7-13-53-14-8-19)47(26)18-27(49)42-25-6-4-21(16-22(25)35)34(38,39)40/h3-7,15-16H,2,8-14,17-18H2,1H3,(H,41,51)(H,42,49)	KJGRFEDZPIHRLQ-UHFFFAOYSA-N	293173	US20260015358, Example 132	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293173	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293173&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124122827	381613455							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192065	CCc1c(N2CCN(C(=O)CNC(=O)c3ncccc3F)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C33H32ClF4N9O5/c1-2-24-28(45-12-10-44(11-13-45)26(49)17-40-30(50)27-22(35)4-3-9-39-27)31(51)47-32(42-29(43-47)19-7-14-52-15-8-19)46(24)18-25(48)41-23-6-5-20(16-21(23)34)33(36,37)38/h3-7,9,16H,2,8,10-15,17-18H2,1H3,(H,40,50)(H,41,48)	PDSJZXMGOGNFGU-UHFFFAOYSA-N	293174	US20260015358, Example 133	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293174	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293174&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123539	381613456							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192066	CCc1c(N2CCN(C(=O)CNC)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C28H32ClF3N8O4/c1-3-21-24(38-10-8-37(9-11-38)23(42)15-33-2)26(43)40-27(35-25(36-40)17-6-12-44-13-7-17)39(21)16-22(41)34-20-5-4-18(14-19(20)29)28(30,31)32/h4-6,14,33H,3,7-13,15-16H2,1-2H3,(H,34,41)	OFTKKCWDYZVKOZ-UHFFFAOYSA-N	293175	US20260015358, Example 134	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293175	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293175&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123251	381613457							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192067	CCc1c(N2CCN(C(=O)C(C)NC(=O)c3ccccc3)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C35H36ClF3N8O5/c1-3-27-29(44-13-15-45(16-14-44)32(50)21(2)40-31(49)23-7-5-4-6-8-23)33(51)47-34(42-30(43-47)22-11-17-52-18-12-22)46(27)20-28(48)41-26-10-9-24(19-25(26)36)35(37,38)39/h4-11,19,21H,3,12-18,20H2,1-2H3,(H,40,49)(H,41,48)	SPBAIZFMDLLACU-UHFFFAOYSA-N	293176	N-(1-(4-(4-(2-((2-Chloro-4-(trifluoromethyl)phenyl)amino)-2-oxoethyl)-2-(3,6-dihydro-2H-pyran-4-yl)-5-ethyl-7-oxo-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)piperazin-1-yl)-1-oxopropan-2-yl)benzamide::US20260015358, Example 136	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293176	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293176&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123076	381613458							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192068	[2H]C([2H])(NC(=O)c1ccccc1F)C(=O)N1CCN(C2=C(CC)C(CC(=O)Nc3ccc(C(F)(F)F)cc3Cl)c3nc(N4CCOCC4)nn3C2=O)CC1	InChI=1S/C34H35ClF4N8O5/c1-2-21-23(18-27(48)41-26-8-7-20(17-24(26)35)34(37,38)39)30-42-33(46-13-15-52-16-14-46)43-47(30)32(51)29(21)45-11-9-44(10-12-45)28(49)19-40-31(50)22-5-3-4-6-25(22)36/h3-8,17,23H,2,9-16,18-19H2,1H3,(H,40,50)(H,41,48)/i19D2	QLRSPLRBZBVAHH-FKUWIZNHSA-N	293177	US20260015358, Example 138	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293177	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293177&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123716	381613459							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192069	CCC1=C(N2CCC(NC(=O)CNC(=O)c3ccccc3)CC2)C(=O)n2nc(C3=CCOCC3)nc2C1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C36H37ClF3N7O5/c1-2-25-26(19-29(48)43-28-9-8-23(18-27(28)37)36(38,39)40)33-44-32(21-12-16-52-17-13-21)45-47(33)35(51)31(25)46-14-10-24(11-15-46)42-30(49)20-41-34(50)22-6-4-3-5-7-22/h3-9,12,18,24,26H,2,10-11,13-17,19-20H2,1H3,(H,41,50)(H,42,49)(H,43,48)	VZKFXHHNADOFAO-UHFFFAOYSA-N	293178	US20260015358, Example 141	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		>1000							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293178	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293178&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123910	381613460							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192070	CCc1c(N2CCN(C(=O)CNC(=O)c3ccccc3)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)N(C)c1ccc(C(F)(F)F)cc1Cl	InChI=1S/C35H36ClF3N8O5/c1-3-26-30(45-15-13-44(14-16-45)28(48)20-40-32(50)23-7-5-4-6-8-23)33(51)47-34(41-31(42-47)22-11-17-52-18-12-22)46(26)21-29(49)43(2)27-10-9-24(19-25(27)36)35(37,38)39/h4-11,19H,3,12-18,20-21H2,1-2H3,(H,40,50)	NNOOGIIFFKOHRI-UHFFFAOYSA-N	293179	US20260015358, Example 143	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		 550							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293179	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293179&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123090	381613461							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192071	CCc1c(N2CCN(C(=O)CNC(=O)c3ccccc3F)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1cc(F)c(C(F)(F)F)cc1C	InChI=1S/C35H35F5N8O5/c1-3-27-30(46-12-10-45(11-13-46)29(50)18-41-32(51)22-6-4-5-7-24(22)36)33(52)48-34(43-31(44-48)21-8-14-53-15-9-21)47(27)19-28(49)42-26-17-25(37)23(16-20(26)2)35(38,39)40/h4-8,16-17H,3,9-15,18-19H2,1-2H3,(H,41,51)(H,42,49)	TVIHCOLAFUXNPK-UHFFFAOYSA-N	293180	US20260015358, Example 144	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		 550							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293180	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293180&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123678	381613462							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192072	CCc1c(N2CCN(C(=O)c3cnn4cccc4c3O)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1sc(C)cc1Br	InChI=1S/C31H32BrN9O5S/c1-3-22-25(37-9-11-38(12-10-37)29(44)20-16-33-40-8-4-5-23(40)26(20)43)30(45)41-31(35-27(36-41)19-6-13-46-14-7-19)39(22)17-24(42)34-28-21(32)15-18(2)47-28/h4-6,8,15-16,43H,3,7,9-14,17H2,1-2H3,(H,34,42)	OEDOGQSDFUXYIZ-UHFFFAOYSA-N	293181	N-(3-Bromo-5-methylthiophen-2-yl)-2-(2-(3,6-dihydro-2H-pyran-4-yl)-5-ethyl-6-(4-(4-hydroxypyrrolo[1,2-b]pyridazine-3-carbonyl)piperazin-1-yl)-7-oxo-[1,2,4]triazolo[1,5-a]pyrimidin-4(7H)-yl)acetamide::US20260015358, Example 146	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		 550							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293181	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293181&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123607	381613463							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192073	CCc1c(N2CCN(C(=O)CNC(=O)c3ccccc3F)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(S(F)(F)(F)(F)F)cc1C	InChI=1S/C34H36F6N8O5S/c1-3-27-30(46-14-12-45(13-15-46)29(50)19-41-32(51)24-6-4-5-7-25(24)35)33(52)48-34(43-31(44-48)22-10-16-53-17-11-22)47(27)20-28(49)42-26-9-8-23(18-21(26)2)54(36,37,38,39)40/h4-10,18H,3,11-17,19-20H2,1-2H3,(H,41,51)(H,42,49)	KELBORHLFNQTPO-UHFFFAOYSA-N	293182	US20260015358, Example 147	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293182	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293182&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123325	381613464							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192074	CCc1c(N2CCN(C(=O)CNC(=O)c3ccccc3F)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1	InChI=1S/C34H34F4N8O5/c1-2-26-29(44-15-13-43(14-16-44)28(48)19-39-31(49)24-5-3-4-6-25(24)35)32(50)46-33(41-30(42-46)21-11-17-51-18-12-21)45(26)20-27(47)40-23-9-7-22(8-10-23)34(36,37)38/h3-11H,2,12-20H2,1H3,(H,39,49)(H,40,47)	CWBCTEIFGGUMTN-UHFFFAOYSA-N	293183	N-(2-(4-(2-(3,6-Dihydro-2H-pyran- 4-yl)-5-ethyl-7-oxo-4-(2-oxo-2-((4- (trifluoromethyl)phenyl)amino)ethyl)- 4,7-dihydro-[1,2,4]triazolo[1,5- a]pyrimidin-6-yl)piperazin-1-yl)-2- oxoethyl)-2-fluorobenzamide::US20260015358, Example 148	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293183	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293183&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123535	381613465							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192075	CCc1c(N2CCN(C(=O)CNC(=O)c3ccccc3F)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1F	InChI=1S/C34H33F5N8O5/c1-2-26-29(45-13-11-44(12-14-45)28(49)18-40-31(50)22-5-3-4-6-23(22)35)32(51)47-33(42-30(43-47)20-9-15-52-16-10-20)46(26)19-27(48)41-25-8-7-21(17-24(25)36)34(37,38)39/h3-9,17H,2,10-16,18-19H2,1H3,(H,40,50)(H,41,48)	PLPCXPVYAUEDKA-UHFFFAOYSA-N	293184	N-(2-(4-(2-(3,6-Dihydro-2H-pyran- 4-yl)-5-ethyl-4-(2-((2-fluoro-4- (trifluoromethyl)phenyl)amino)-2- oxoethyl)-7-oxo-4,7-dihydro- [1,2,4]triazolo[1,5-a]pyrimidin-6- yl)piperazin-1-yl)-2-oxoethyl)-2- fluorobenzamide::US20260015358, Example 149	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293184	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293184&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123528	381613466							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192076	CCc1c(N2CCN(C(=O)CNC(=O)c3ccccc3F)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(F)cc1F	InChI=1S/C33H33F3N8O5/c1-2-26-29(42-13-11-41(12-14-42)28(46)18-37-31(47)22-5-3-4-6-23(22)35)32(48)44-33(39-30(40-44)20-9-15-49-16-10-20)43(26)19-27(45)38-25-8-7-21(34)17-24(25)36/h3-9,17H,2,10-16,18-19H2,1H3,(H,37,47)(H,38,45)	RDNFZOLEJXPNTG-UHFFFAOYSA-N	293185	N-(2-(4-(4-(2-((2,4- Difluorophenyl)amino)-2- oxoethyl)-2-(3,6-dihydro-2H- pyran-4-yl)-5-ethyl-7-oxo-4,7- dihydro-[1,2,4]triazolo[1,5- a]pyrimidin-6-yl)piperazin-1-yl)-2- oxoethyl)-2-fluorobenzamide::US20260015358, Example 150	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293185	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293185&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123206	381613467							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192077	CCc1c(N2CCN(C(=O)CNC(=O)c3ccccc3F)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1sc(C)cc1Br	InChI=1S/C32H34BrFN8O5S/c1-3-24-27(40-12-10-39(11-13-40)26(44)17-35-29(45)21-6-4-5-7-23(21)34)31(46)42-32(37-28(38-42)20-8-14-47-15-9-20)41(24)18-25(43)36-30-22(33)16-19(2)48-30/h4-8,16H,3,9-15,17-18H2,1-2H3,(H,35,45)(H,36,43)	DUCJGBDWABZQPQ-UHFFFAOYSA-N	293186	N-(2-(4-(4-(2-((3-bromo-5- methylthiophen-2-yl)amino)-2- oxoethyl)-2-(3,6-dihydro-2H- pyran-4-yl)-5-ethyl-7-oxo-4,7- dihydro-[1,2,4]triazolo[1,5- a]pyrimidin-6-yl)piperazin-1-yl)-2- oxoethyl)-2-fluorobenzamide::US20260015358, Example 152	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		 550							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293186	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293186&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123579	381613468							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192078	CCc1c(N2CCN(C(=O)CNC(=O)c3ccccc3F)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C)s1	InChI=1S/C32H35FN8O5S/c1-3-24-28(39-14-12-38(13-15-39)27(43)18-34-30(44)22-6-4-5-7-23(22)33)31(45)41-32(36-29(37-41)21-10-16-46-17-11-21)40(24)19-25(42)35-26-9-8-20(2)47-26/h4-10H,3,11-19H2,1-2H3,(H,34,44)(H,35,42)	IDEWQMRTDXOHRX-UHFFFAOYSA-N	293187	N-(2-(4-(2-(3,6-Dihydro-2H-pyran- 4-yl)-5-ethyl-4-(2-((5- methylthiophen-2-yl)amino)-2- oxoethyl)-7-oxo-4,7-dihydro- [1,2,4]triazolo[1,5-a]pyrimidin-6- yl)piperazin-1-yl)-2-oxoethyl)-2- fluorobenzamide::US20260015358, Example 153	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		 550							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293187	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293187&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123721	381613469							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192079	CCc1c(N2CCN(C(=O)CNC(=O)c3ccccc3F)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1cc(C)cs1	InChI=1S/C32H35FN8O5S/c1-3-24-28(39-12-10-38(11-13-39)27(43)17-34-30(44)22-6-4-5-7-23(22)33)31(45)41-32(36-29(37-41)21-8-14-46-15-9-21)40(24)18-25(42)35-26-16-20(2)19-47-26/h4-8,16,19H,3,9-15,17-18H2,1-2H3,(H,34,44)(H,35,42)	DTXOROFOWLPNCK-UHFFFAOYSA-N	293188	N-(2-(4-(2-(3,6-Dihydro-2H-pyran- 4-yl)-5-ethyl-4-(2-((4- methylthiophen-2-yl)amino)-2- oxoethyl)-7-oxo-4,7-dihydro- [1,2,4]triazolo[1,5-a]pyrimidin-6- yl)piperazin-1-yl)-2-oxoethyl)-2- fluorobenzamide::US20260015358, Example 154	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293188	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293188&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124122954	381613470							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192080	CCc1c(N2CCN(C(=O)CNC(=O)c3ccccc3F)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1cnc(C(F)(F)F)s1	InChI=1S/C31H31F4N9O5S/c1-2-21-25(42-11-9-41(10-12-42)24(46)16-36-27(47)19-5-3-4-6-20(19)32)28(48)44-30(39-26(40-44)18-7-13-49-14-8-18)43(21)17-22(45)38-23-15-37-29(50-23)31(33,34)35/h3-7,15H,2,8-14,16-17H2,1H3,(H,36,47)(H,38,45)	NVWVDOLUJTWHPN-UHFFFAOYSA-N	293189	N-(2-(4-(2-(3,6-Dihydro-2H-pyran- 4-yl)-5-ethyl-7-oxo-4-(2-oxo-2-((2- (trifluoromethyl)thiazol-5- yl)amino)ethyl)-4,7-dihydro- [1,2,4]triazolo[1,5-a]pyrimidin-6- yl)piperazin-1-yl)-2-oxoethyl)-2- fluorobenzamide::US20260015358, Example 157	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293189	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293189&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123374	381613471							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192081	CCc1c(N2CCN(C(=O)CNC(=O)c3ccccc3F)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1cc(Br)cs1	InChI=1S/C31H32BrFN8O5S/c1-2-23-27(39-11-9-38(10-12-39)26(43)16-34-29(44)21-5-3-4-6-22(21)33)30(45)41-31(36-28(37-41)19-7-13-46-14-8-19)40(23)17-24(42)35-25-15-20(32)18-47-25/h3-7,15,18H,2,8-14,16-17H2,1H3,(H,34,44)(H,35,42)	IJOGUABEYYQWDQ-UHFFFAOYSA-N	293190	N-(2-(4-(4-(2-((4-Bromothiophen- 2-yl)amino)-2-oxoethyl)-2-(3,6- dihydro-2H-pyran-4-yl)-5-ethyl-7- oxo-4,7-dihydro- [1,2,4]triazolo[1,5-a]pyrimidin-6- yl)piperazin-1-yl)-2-oxoethyl)-2- fluorobenzamide::US20260015358, Example 161	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293190	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293190&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123205	381613472							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192082	CCc1c(N2CCN(C(=O)CNC(=O)c3ccccc3F)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1cc(C(F)(F)F)n(C)n1	InChI=1S/C32H34F4N10O5/c1-3-22-27(44-12-10-43(11-13-44)26(48)17-37-29(49)20-6-4-5-7-21(20)33)30(50)46-31(39-28(41-46)19-8-14-51-15-9-19)45(22)18-25(47)38-24-16-23(32(34,35)36)42(2)40-24/h4-8,16H,3,9-15,17-18H2,1-2H3,(H,37,49)(H,38,40,47)	BQHRGMHUVKGIQX-UHFFFAOYSA-N	293191	N-(2-(4-(2-(3,6-Dihydro-2H-pyran- 4-yl)-5-ethyl-4-(2-((1-methyl-5- (trifluoromethyl)-1H-pyrazol-3- yl)amino)-2-oxoethyl)-7-oxo-4,7- dihydro-[1,2,4]triazolo[1,5- a]pyrimidin-6-yl)piperazin-1-yl)-2- oxoethyl)-2-fluorobenzamide::US20260015358, Example 162	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		 550							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293191	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293191&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124122912	381613473							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192083	CCc1c(N2CCN(C(=O)CNC(=O)c3ccccc3F)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)nc1Cl	InChI=1S/C33H32ClF4N9O5/c1-2-23-27(45-13-11-44(12-14-45)26(49)17-39-30(50)20-5-3-4-6-21(20)35)31(51)47-32(42-29(43-47)19-9-15-52-16-10-19)46(23)18-25(48)40-22-7-8-24(33(36,37)38)41-28(22)34/h3-9H,2,10-18H2,1H3,(H,39,50)(H,40,48)	SYSMBUXQNISSAM-UHFFFAOYSA-N	293192	N-(2-(4-(4-(2-((2-Chloro-6- (trifluoromethyl)pyridin-3- yl)amino)-2-oxoethyl)-2-(3,6- dihydro-2H-pyran-4-yl)-5-ethyl-7- oxo-4,7-dihydro- [1,2,4]triazolo[1,5-a]pyrimidin-6- yl)piperazin-1-yl)-2-oxoethyl)-2- fluorobenzamide::US20260015358, Example 163	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293192	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293192&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123536	381613474							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192084	CCc1c(N2CCN(C(=O)C(=O)NCC3CC3)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C31H34ClF3N8O5/c1-2-23-25(40-9-11-41(12-10-40)29(47)27(45)36-16-18-3-4-18)28(46)43-30(38-26(39-43)19-7-13-48-14-8-19)42(23)17-24(44)37-22-6-5-20(15-21(22)32)31(33,34)35/h5-7,15,18H,2-4,8-14,16-17H2,1H3,(H,36,45)(H,37,44)	XXLXFCFSJDNVSB-UHFFFAOYSA-N	293193	US20260015358, Example 165	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293193	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293193&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124122887	381613475							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192085	CCc1c(N2CCN(C(=O)CNC(=O)N3CCCC3)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C32H37ClF3N9O5/c1-2-24-27(42-13-11-41(12-14-42)26(47)18-37-31(49)43-9-3-4-10-43)29(48)45-30(39-28(40-45)20-7-15-50-16-8-20)44(24)19-25(46)38-23-6-5-21(17-22(23)33)32(34,35)36/h5-7,17H,2-4,8-16,18-19H2,1H3,(H,37,49)(H,38,46)	NKCZALLMIVYMPV-UHFFFAOYSA-N	293194	N-(2-(4-(4-(2-((2-Chloro-4- (trifluoromethyl)phenyl)amino)-2- oxoethyl)-2-(3,6-dihydro-2H- pyran-4-yl)-5-ethyl-7-oxo-4,7- dihydro-[1,2,4]triazolo[1,5- a]pyrimidin-6-yl)piperazin-1-yl)-2- oxoethyl)pyrrolidine-1- carboxamide::US20260015358, Example 166	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		 550							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293194	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293194&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123188	381613476							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192086	CCOC(=O)NCC(=O)N1CCN(c2c(CC)n(CC(=O)Nc3ccc(C(F)(F)F)cc3Cl)c3nc(C4=CCOCC4)nn3c2=O)CC1	InChI=1S/C30H34ClF3N8O6/c1-3-22-25(40-11-9-39(10-12-40)24(44)16-35-29(46)48-4-2)27(45)42-28(37-26(38-42)18-7-13-47-14-8-18)41(22)17-23(43)36-21-6-5-19(15-20(21)31)30(32,33)34/h5-7,15H,3-4,8-14,16-17H2,1-2H3,(H,35,46)(H,36,43)	CUZWQALWLXWMPJ-UHFFFAOYSA-N	293195	Ethyl (2-(4-(4-(2-((2-chloro-4- (trifluoromethyl)phenyl)amino)-2- oxoethyl)-2-(3,6-dihydro-2H- pyran-4-yl)-5-ethyl-7-oxo-4,7- dihydro-[1,2,4]triazolo[1,5- a]pyrimidin-6-yl)piperazin-1-yl)-2- oxoethyl)carbamate::US20260015358, Example 167	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293195	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293195&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123633	381613477							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192087	CCc1c(N2CCN(C(=O)CNC(C)=O)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C29H32ClF3N8O5/c1-3-22-25(39-10-8-38(9-11-39)24(44)15-34-17(2)42)27(45)41-28(36-26(37-41)18-6-12-46-13-7-18)40(22)16-23(43)35-21-5-4-19(14-20(21)30)29(31,32)33/h4-6,14H,3,7-13,15-16H2,1-2H3,(H,34,42)(H,35,43)	VHFZRYFGWXBAMC-UHFFFAOYSA-N	293196	2-(6-(4-(Acetylglycyl)piperazin-1- yl)-2-(3,6-dihydro-2H-pyran-4-yl)- 5-ethyl-7-oxo-[1,2,4]triazolo[1,5- a]pyrimidin-4(7H)-yl)-N-(2-chloro- 4- (trifluoromethyl)phenyl)acetamide::US20260015358, Example 168	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293196	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293196&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123434	381613478							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192088	CCc1c(N2CCN(C(=O)CNC(=O)C(C)(C)C)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C32H38ClF3N8O5/c1-5-23-26(42-12-10-41(11-13-42)25(46)17-37-29(48)31(2,3)4)28(47)44-30(39-27(40-44)19-8-14-49-15-9-19)43(23)18-24(45)38-22-7-6-20(16-21(22)33)32(34,35)36/h6-8,16H,5,9-15,17-18H2,1-4H3,(H,37,48)(H,38,45)	RWOMDRMQAZQYJE-UHFFFAOYSA-N	293197	N-(2-(4-(4-(2-((2-Chloro-4- (trifluoromethyl)phenyl)amino)-2- oxoethyl)-2-(3,6-dihydro-2H- pyran-4-yl)-5-ethyl-7-oxo-4,7- dihydro-[1,2,4]triazolo[1,5- a]pyrimidin-6-yl)piperazin-1-yl)-2- oxoethyl)pivalamide::US20260015358, Example 169	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		 550							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293197	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293197&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123445	381613479							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192089	CCc1c(N2CCN(C(=O)CNS(C)(=O)=O)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C28H32ClF3N8O6S/c1-3-21-24(38-10-8-37(9-11-38)23(42)15-33-47(2,44)45)26(43)40-27(35-25(36-40)17-6-12-46-13-7-17)39(21)16-22(41)34-20-5-4-18(14-19(20)29)28(30,31)32/h4-6,14,33H,3,7-13,15-16H2,1-2H3,(H,34,41)	KSUKFIOMIXHBDG-UHFFFAOYSA-N	293198	N-(2-Chloro-4- (trifluoromethyl)phenyl)-2-(2-(3,6- dihydro-2H-pyran-4-yl)-5-ethyl-6- (4- ((methylsulfonyl)glycyl)piperazin- 1-yl)-7-oxo-[1,2,4]triazolo[1,5- a]pyrimidin-4(7H)-yl)acetamide::US20260015358, Example 170	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		 550							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293198	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293198&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123232	381613480							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192090	CCc1c(N2CCN(C(=O)CNS(=O)(=O)c3ccccc3)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C33H34ClF3N8O6S/c1-2-26-29(43-14-12-42(13-15-43)28(47)19-38-52(49,50)23-6-4-3-5-7-23)31(48)45-32(40-30(41-45)21-10-16-51-17-11-21)44(26)20-27(46)39-25-9-8-22(18-24(25)34)33(35,36)37/h3-10,18,38H,2,11-17,19-20H2,1H3,(H,39,46)	RAMKXPWBJSVUOE-UHFFFAOYSA-N	293199	N-(2-Chloro-4- (trifluoromethyl)phenyl)-2-(2-(3,6- dihydro-2H-pyran-4-yl)-5-ethyl-7- oxo-6-(4-(2- (phenylsulfonamido)acetyl)piperazin- 1-yl)-[1,2,4]triazolo[1,5- a]pyrimidin-4(7H)-yl)acetamide::US20260015358, Example 171	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		 550							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293199	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293199&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123412	381613481							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192091	CCc1c(N2CCN(C(=O)CNC(=O)N(C)C)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C30H35ClF3N9O5/c1-4-22-25(41-11-9-40(10-12-41)24(45)16-35-29(47)39(2)3)27(46)43-28(37-26(38-43)18-7-13-48-14-8-18)42(22)17-23(44)36-21-6-5-19(15-20(21)31)30(32,33)34/h5-7,15H,4,8-14,16-17H2,1-3H3,(H,35,47)(H,36,44)	JJALSOZWJKEAGL-UHFFFAOYSA-N	293200	N-(2-Chloro-4- (trifluoromethyl)phenyl)-2-(2-(3,6- dihydro-2H-pyran-4-yl)-6-(4- ((dimethylcarbamoyl)glycyl) piperazin-1-yl)-5-ethyl-7-oxo- [1,2,4]triazolo[1,5-a]pyrimidin- 4(7H)-yl)acetamide::US20260015358, Example 173	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		 550							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293200	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293200&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123255	381613482							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192092	CCc1c(N2CCN(C(=O)CNC(=O)COC)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C30H34ClF3N8O6/c1-3-22-26(40-10-8-39(9-11-40)25(45)15-35-24(44)17-47-2)28(46)42-29(37-27(38-42)18-6-12-48-13-7-18)41(22)16-23(43)36-21-5-4-19(14-20(21)31)30(32,33)34/h4-6,14H,3,7-13,15-17H2,1-2H3,(H,35,44)(H,36,43)	QKKRWUHSSPKLBA-UHFFFAOYSA-N	293201	N-(2-Chloro-4- (trifluoromethyl)phenyl)-2-(2-(3,6- dihydro-2H-pyran-4-yl)-5-ethyl-6- (4-((2- methoxyacetyl)glycyl)piperazin-1- yl)-7-oxo-[1,2,4]triazolo[1,5- a]pyrimidin-4(7H)-yl)acetamide::US20260015358, Example 174	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293201	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293201&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123468	381613483							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192093	CCc1c(N2CCN(C(=O)CNC(=O)c3ccc(C(F)(F)F)cc3)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C35H33ClF6N8O5/c1-2-26-29(48-13-11-47(12-14-48)28(52)18-43-31(53)21-3-5-22(6-4-21)34(37,38)39)32(54)50-33(45-30(46-50)20-9-15-55-16-10-20)49(26)19-27(51)44-25-8-7-23(17-24(25)36)35(40,41)42/h3-9,17H,2,10-16,18-19H2,1H3,(H,43,53)(H,44,51)	FXIHMZKNMRGKRU-UHFFFAOYSA-N	293202	N-(2-(4-(4-(2-((2-Chloro-4- (trifluoromethyl)phenyl)amino)-2- oxoethyl)-2-(3,6-dihydro-2H- pyran-4-yl)-5-ethyl-7-oxo-4,7- dihydro-[1,2,4]triazolo[1,5- a]Pyrimidin-6-yl)piperazin-1-yl)-2- oxoethyl)-4- (trifluoromethyl)benzamide::US20260015358, Example 176	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		 550							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293202	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293202&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123062	381613484							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192094	CCc1c(N2CCN(C(=O)CNC(=O)Cc3ccc(F)cc3)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C35H35ClF4N8O5/c1-2-27-31(46-13-11-45(12-14-46)30(51)19-41-28(49)17-21-3-6-24(37)7-4-21)33(52)48-34(43-32(44-48)22-9-15-53-16-10-22)47(27)20-29(50)42-26-8-5-23(18-25(26)36)35(38,39)40/h3-9,18H,2,10-17,19-20H2,1H3,(H,41,49)(H,42,50)	ACAQKIFZCVLXAN-UHFFFAOYSA-N	293203	N-(2-Chloro-4- (trifluoromethyl)phenyl)-2-(2-(3,6- dihydro-2H-pyran-4-yl)-5-ethyl-6- (4-((2-(4- fluorophenyl)acetyl)glycyl)piperazin- 1-yl)-7-oxo-[1,2,4]triazolo[1,5- a]pyrimidin-4(7H)-yl)acetamide::US20260015358, Example 177	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293203	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293203&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123671	381613485							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192095	CCC1=C(N2CCN(C(=O)CNC(=O)Nc3ccccc3)CC2)C(=O)n2nc(C3=CCOCC3)nc2C1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C35H36ClF3N8O5/c1-2-24-25(19-28(48)42-27-9-8-22(18-26(27)36)35(37,38)39)32-43-31(21-10-16-52-17-11-21)44-47(32)33(50)30(24)46-14-12-45(13-15-46)29(49)20-40-34(51)41-23-6-4-3-5-7-23/h3-10,18,25H,2,11-17,19-20H2,1H3,(H,42,48)(H2,40,41,51)	IUIXDDADOFBWGG-UHFFFAOYSA-N	293204	US20260015358, Example 178	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293204	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293204&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123897	381613486							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192096	CCC1=C(N2CCN(C(=O)CNC(=O)Nc3cc(F)cc(F)c3)CC2)C(=O)n2nc(C3=CCOCC3)nc2C1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C35H34ClF5N8O5/c1-2-24-25(17-28(50)44-27-4-3-20(13-26(27)36)35(39,40)41)32-45-31(19-5-11-54-12-6-19)46-49(32)33(52)30(24)48-9-7-47(8-10-48)29(51)18-42-34(53)43-23-15-21(37)14-22(38)16-23/h3-5,13-16,25H,2,6-12,17-18H2,1H3,(H,44,50)(H2,42,43,53)	QJRSWYJARTYCGA-UHFFFAOYSA-N	293205	US20260015358, Example 179	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293205	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293205&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123647	381613487							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192097	CCc1c(N2CCN(C(=O)CNC(=O)Nc3ccccc3F)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C34H34ClF4N9O5/c1-2-26-29(46-13-11-45(12-14-46)28(50)18-40-32(52)42-25-6-4-3-5-23(25)36)31(51)48-33(43-30(44-48)20-9-15-53-16-10-20)47(26)19-27(49)41-24-8-7-21(17-22(24)35)34(37,38)39/h3-9,17H,2,10-16,18-19H2,1H3,(H,41,49)(H2,40,42,52)	BZDJXEXENYVXJH-UHFFFAOYSA-N	293206	US20260015358, Example 180	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293206	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293206&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123861	381613488							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192098	CCc1c(N2CCN(C(=O)CNC(=O)Nc3ccccc3Cl)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C34H34Cl2F3N9O5/c1-2-26-29(46-13-11-45(12-14-46)28(50)18-40-32(52)42-24-6-4-3-5-22(24)35)31(51)48-33(43-30(44-48)20-9-15-53-16-10-20)47(26)19-27(49)41-25-8-7-21(17-23(25)36)34(37,38)39/h3-9,17H,2,10-16,18-19H2,1H3,(H,41,49)(H2,40,42,52)	JKVAJTCGFUBRPA-UHFFFAOYSA-N	293207	US20260015358, Example 181	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293207	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293207&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123655	381613489							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192099	CCc1c(N2CCN(C(=O)CNC(=O)N3CCc4ccccc43)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C36H37ClF3N9O5/c1-2-27-31(46-15-13-45(14-16-46)30(51)20-41-35(53)47-12-9-22-5-3-4-6-28(22)47)33(52)49-34(43-32(44-49)23-10-17-54-18-11-23)48(27)21-29(50)42-26-8-7-24(19-25(26)37)36(38,39)40/h3-8,10,19H,2,9,11-18,20-21H2,1H3,(H,41,53)(H,42,50)	JFZHWMNKXYERFO-UHFFFAOYSA-N	293208	N-(2-(4-(4-(2-((2-Chloro-4-(trifluoromethyl)phenyl)amino)-2-oxoethyl)-2-(3,6-dihydro-2H-pyran-4-yl)-5-ethyl-7-oxo-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)piperazin-1-yl)-2-oxoethyl)indoline-1-carboxamide::US20260015358, Example 182	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293208	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293208&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123019	381613490							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192100	CCc1c(N2CCN(C(=O)CNC(=O)NCc3ccccc3)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C35H37ClF3N9O5/c1-2-27-30(46-14-12-45(13-15-46)29(50)20-41-33(52)40-19-22-6-4-3-5-7-22)32(51)48-34(43-31(44-48)23-10-16-53-17-11-23)47(27)21-28(49)42-26-9-8-24(18-25(26)36)35(37,38)39/h3-10,18H,2,11-17,19-21H2,1H3,(H,42,49)(H2,40,41,52)	IBWPCFGEJFQRGW-UHFFFAOYSA-N	293209	2-(6-(4- ((Benzylcarbamoyl)glycyl)piperazin- 1-yl)-2-(3,6-dihydro-2H-pyran-4- yl)-5-ethyl-7-oxo- [1,2,4]triazolo[1,5-a]pyrimidin- 4(7H)-yl)-N-(2-chloro-4- (trifluoromethyl)phenyl)acetamide::US20260015358, Example 183	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293209	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293209&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123760	381613491							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192101	CCC1=C(N2CCN(C(=O)CNC(=O)NC3CC3)CC2)C(=O)n2nc(C3=CCOCC3)nc2C1CC(=O)Nc1ccc(C(F)(F)F)cc1F	InChI=1S/C32H36F4N8O5/c1-2-21-22(16-25(45)39-24-6-3-19(15-23(24)33)32(34,35)36)29-40-28(18-7-13-49-14-8-18)41-44(29)30(47)27(21)43-11-9-42(10-12-43)26(46)17-37-31(48)38-20-4-5-20/h3,6-7,15,20,22H,2,4-5,8-14,16-17H2,1H3,(H,39,45)(H2,37,38,48)	ZIZWYPSUDLIUON-UHFFFAOYSA-N	293210	N-(2-Chloro-4- (trifluoromethyl)phenyl)-2-(6-(4- ((cyclopropylcarbamoyl)glycyl) piperazin-1-yl)-2-(3,6-dihydro-2H- pyran-4-yl)-5-ethyl-7-oxo- [1,2,4]triazolo[1,5-a]pyrimidin- 4(7H)-yl)acetamide::US20260015358, Example 184	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293210	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293210&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123938	381613492							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192102	CCc1c(N2CCN(C(=O)CNC(=O)N3Cc4ccccc4C3)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C36H37ClF3N9O5/c1-2-28-31(46-13-11-45(12-14-46)30(51)18-41-35(53)47-19-23-5-3-4-6-24(23)20-47)33(52)49-34(43-32(44-49)22-9-15-54-16-10-22)48(28)21-29(50)42-27-8-7-25(17-26(27)37)36(38,39)40/h3-9,17H,2,10-16,18-21H2,1H3,(H,41,53)(H,42,50)	FBGKJHAKDYATBU-UHFFFAOYSA-N	293211	N-(2-(4-(4-(2-((2-Chloro-4- (trifluoromethyl)phenyl)amino)-2- oxoethyl)-2-(3,6-dihydro-2H- pyran-4-yl)-5-ethyl-7-oxo-4,7- dihydro-[1,2,4]triazolo[1,5- a]pyrimidin-6-yl)piperazin-1-yl)-2- oxoethyl)isoindoline-2- carboxamide::US20260015358, Example 185	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293211	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293211&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123258	381613493							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192103	CCc1c(N2CCN(C(=O)CNC(=O)Nc3cc(F)ccc3F)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C34H33ClF5N9O5/c1-2-26-29(47-11-9-46(10-12-47)28(51)17-41-32(53)43-25-16-21(36)4-5-23(25)37)31(52)49-33(44-30(45-49)19-7-13-54-14-8-19)48(26)18-27(50)42-24-6-3-20(15-22(24)35)34(38,39)40/h3-7,15-16H,2,8-14,17-18H2,1H3,(H,42,50)(H2,41,43,53)	BGHCZAJKMQJSLW-UHFFFAOYSA-N	293212	N-(2-Chloro-4- (trifluoromethyl)phenyl)-2-(6-(4- (((2,5- difluorophenyl)carbamoyl)glycyl) piperazin-1-yl)-2-(3,6-dihydro-2H- pyran-4-yl)-5-ethyl-7-oxo- [1,2,4]triazolo[1,5-a]pyrimidin- 4(7H)-yl)acetamide::US20260015358, Example 186	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293212	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293212&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124129603	381613494							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192104	CCc1c(N2CCN(C(=O)CNC(=O)Nc3ccccc3C#N)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C35H34ClF3N10O5/c1-2-27-30(47-13-11-46(12-14-47)29(51)19-41-33(53)43-25-6-4-3-5-22(25)18-40)32(52)49-34(44-31(45-49)21-9-15-54-16-10-21)48(27)20-28(50)42-26-8-7-23(17-24(26)36)35(37,38)39/h3-9,17H,2,10-16,19-20H2,1H3,(H,42,50)(H2,41,43,53)	XMTQSJMPZSUMES-UHFFFAOYSA-N	293213	N-(2-Chloro-4- (trifluoromethyl)phenyl)-2-(6-(4- (((2- cyanophenyl)carbamoyl)glycyl) piperazin-1-yl)-2-(3,6-dihydro-2H- pyran-4-yl)-5-ethyl-7-oxo- [1,2,4]triazolo[1,5-a]pyrimidin- 4(7H)-yl)acetamide::US20260015358, Example 187	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293213	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293213&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123180	381613495							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192105	CCc1c(N2CCN(C(=O)CNC(=O)Nc3nccs3)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C31H32ClF3N10O5S/c1-2-22-25(43-10-8-42(9-11-43)24(47)16-37-28(49)40-29-36-7-14-51-29)27(48)45-30(39-26(41-45)18-5-12-50-13-6-18)44(22)17-23(46)38-21-4-3-19(15-20(21)32)31(33,34)35/h3-5,7,14-15H,2,6,8-13,16-17H2,1H3,(H,38,46)(H2,36,37,40,49)	SHJLZDHGBPUDKB-UHFFFAOYSA-N	293214	N-(2-Chloro-4- (trifluoromethyl)phenyl)-2-(2-(3,6- dihydro-2H-pyran-4-yl)-5-ethyl-7- oxo-6-(4-((thiazol-2- ylcarbamoyl)glycyl)piperazin-1-yl)- [1,2,4]triazolo[1,5-a]pyrimidin- 4(7H)-yl)acetamide::US20260015358, Example 188	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293214	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293214&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123674	381613496							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192106	CCc1c(N2CCN(C(=O)CNC(=O)N(C)Cc3ccccc3)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C36H39ClF3N9O5/c1-3-28-31(47-15-13-46(14-16-47)30(51)20-41-35(53)45(2)21-23-7-5-4-6-8-23)33(52)49-34(43-32(44-49)24-11-17-54-18-12-24)48(28)22-29(50)42-27-10-9-25(19-26(27)37)36(38,39)40/h4-11,19H,3,12-18,20-22H2,1-2H3,(H,41,53)(H,42,50)	SPJVVMSRWWCNHN-UHFFFAOYSA-N	293215	2-(6-(4- ((Benzyl(methyl)carbamoyl)glycyl) piperazin-1-yl)-2-(3,6-dihydro-2H- pyran-4-yl)-5-ethyl-7-oxo- [1,2,4]triazolo[1,5-a]pyrimidin- 4(7H)-yl)-N-(2-chloro-4- (trifluoromethyl)phenyl)acetamide::US20260015358, Example 189	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293215	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293215&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124122985	381613497							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192107	CCc1c(N2CCN(C(=O)CNC(=O)NCC3CC3)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C32H37ClF3N9O5/c1-2-24-27(43-11-9-42(10-12-43)26(47)17-38-30(49)37-16-19-3-4-19)29(48)45-31(40-28(41-45)20-7-13-50-14-8-20)44(24)18-25(46)39-23-6-5-21(15-22(23)33)32(34,35)36/h5-7,15,19H,2-4,8-14,16-18H2,1H3,(H,39,46)(H2,37,38,49)	IFVHUAFAVSQJCF-UHFFFAOYSA-N	293216	N-(2-Chloro-4- (trifluoromethyl)phenyl)-2-(6-(4- (((cyclopropylmethyl)carbamoyl) glycyl)piperazin-1-yl)-2-(3,6- dihydro-2H-pyran-4-yl)-5-ethyl-7- oxo-[1,2,4]triazolo[1,5- a]pyrimidin-4(7H)-yl)acetamide::US20260015358, Example 190	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293216	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293216&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123639	381613498							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192108	CCc1c(N2CCN(C(=O)CNC(=O)NCc3ccccc3F)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C35H36ClF4N9O5/c1-2-27-30(47-13-11-46(12-14-47)29(51)19-42-33(53)41-18-22-5-3-4-6-25(22)37)32(52)49-34(44-31(45-49)21-9-15-54-16-10-21)48(27)20-28(50)43-26-8-7-23(17-24(26)36)35(38,39)40/h3-9,17H,2,10-16,18-20H2,1H3,(H,43,50)(H2,41,42,53)	WNCZMMJGVVMDGP-UHFFFAOYSA-N	293217	N-(2-Chloro-4- (trifluoromethyl)phenyl)-2-(2-(3,6- dihydro-2H-pyran-4-yl)-5-ethyl-6- (4-(((2- fluorobenzyl)carbamoyl)glycyl) piperazin-1-yl)-7-oxo- [1,2,4]triazolo[1,5-a]pyrimidin- 4(7H)-yl)acetamide::US20260015358, Example 191	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293217	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293217&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124122864	381613499							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192109	CCc1c(N2CCN(C(=O)CNC(=O)N3Cc4ccncc4C3)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C35H36ClF3N10O5/c1-2-27-30(46-11-9-45(10-12-46)29(51)17-41-34(53)47-18-22-5-8-40-16-23(22)19-47)32(52)49-33(43-31(44-49)21-6-13-54-14-7-21)48(27)20-28(50)42-26-4-3-24(15-25(26)36)35(37,38)39/h3-6,8,15-16H,2,7,9-14,17-20H2,1H3,(H,41,53)(H,42,50)	JIQVWNQKTGRICU-UHFFFAOYSA-N	293218	N-(2-(4-(4-(2-((2-Chloro-4- (trifluoromethyl)phenyl)amino)-2- oxoethyl)-2-(3,6-dihydro-2H- pyran-4-yl)-5-ethyl-7-oxo-4,7- dihydro-[1,2,4]triazolo[1,5- a]pyrimidin-6-yl)piperazin-1-yl)-2- oxoethyl)-1,3-dihydro-2H- pyrrolo[3,4-c]pyridine-2- carboxamide::US20260015358, Example 192	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293218	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293218&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123398	381613500							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192110	CCc1c(N2CCN(C(=O)CNC(=O)N3CCc4cccc(F)c43)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C36H36ClF4N9O5/c1-2-27-31(47-14-12-46(13-15-47)29(52)19-42-35(54)48-11-8-21-4-3-5-25(38)30(21)48)33(53)50-34(44-32(45-50)22-9-16-55-17-10-22)49(27)20-28(51)43-26-7-6-23(18-24(26)37)36(39,40)41/h3-7,9,18H,2,8,10-17,19-20H2,1H3,(H,42,54)(H,43,51)	MALMYTAWTBBYNE-UHFFFAOYSA-N	293219	N-(2-(4-(4-(2-((2-Chloro-4- (trifluoromethyl)phenyl)amino)-2- oxoethyl)-2-(3,6-dihydro-2H- pyran-4-yl)-5-ethyl-7-oxo-4,7- dihydro-[1,2,4]triazolo[1,5- a]pyrimidin-6-yl)piperazin-1-yl)-2- oxoethyl)-7-fluoroindoline-1- carboxamide::US20260015358, Example 193	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293219	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293219&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123121	381613501							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192111	CCc1c(N2CCN(S(=O)(=O)NC(=O)c3ccccc3)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C32H32ClF3N8O6S/c1-2-25-27(41-12-14-42(15-13-41)51(48,49)40-29(46)21-6-4-3-5-7-21)30(47)44-31(38-28(39-44)20-10-16-50-17-11-20)43(25)19-26(45)37-24-9-8-22(18-23(24)33)32(34,35)36/h3-10,18H,2,11-17,19H2,1H3,(H,37,45)(H,40,46)	ZLROFTLPZKFWGU-UHFFFAOYSA-N	293220	US20260015358, Example 194	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293220	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293220&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123450	381613502							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192112	CCc1c(N2CCN(C(=O)c3ncc4ncsc4c3O)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C32H29ClF3N9O5S/c1-2-22-25(42-7-9-43(10-8-42)29(48)24-26(47)27-21(14-37-24)38-16-51-27)30(49)45-31(40-28(41-45)17-5-11-50-12-6-17)44(22)15-23(46)39-20-4-3-18(13-19(20)33)32(34,35)36/h3-5,13-14,16,47H,2,6-12,15H2,1H3,(H,39,46)	FFGRMLZCLZGIOP-UHFFFAOYSA-N	293221	US20260015358, Example 195	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293221	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293221&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123134	381613503							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192113	CCc1c(N2CCN(C(=O)c3ncc4nc(Cl)sc4c3O)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C32H28Cl2F3N9O5S/c1-2-21-24(43-7-9-44(10-8-43)28(49)23-25(48)26-20(14-38-23)40-30(34)52-26)29(50)46-31(41-27(42-46)16-5-11-51-12-6-16)45(21)15-22(47)39-19-4-3-17(13-18(19)33)32(35,36)37/h3-5,13-14,48H,2,6-12,15H2,1H3,(H,39,47)	HZCCCYKTWQSCAT-UHFFFAOYSA-N	293222	US20260015358, Example 196	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293222	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293222&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123695	381613504							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192114	CCc1c(N2CCN(C(=O)c3cc4sccc4[nH]c3=O)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C33H30ClF3N8O5S/c1-2-24-27(42-8-10-43(11-9-42)30(48)20-16-25-23(7-14-51-25)39-29(20)47)31(49)45-32(40-28(41-45)18-5-12-50-13-6-18)44(24)17-26(46)38-22-4-3-19(15-21(22)34)33(35,36)37/h3-5,7,14-16H,2,6,8-13,17H2,1H3,(H,38,46)(H,39,47)	CAHKXKYXEDIJJH-UHFFFAOYSA-N	293223	US20260015358, Example 197	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293223	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293223&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123462	381613505							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192115	CCc1c(N2CCN(C(=O)c3c(O)nn4c(Cl)cccc34)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C33H30Cl2F3N9O5/c1-2-22-27(43-10-12-44(13-11-43)30(50)26-23-4-3-5-24(35)46(23)42-29(26)49)31(51)47-32(40-28(41-47)18-8-14-52-15-9-18)45(22)17-25(48)39-21-7-6-19(16-20(21)34)33(36,37)38/h3-8,16H,2,9-15,17H2,1H3,(H,39,48)(H,42,49)	XDGVMZXHXLGBCZ-UHFFFAOYSA-N	293224	2-(6-(4-(7-Chloro-2-hydroxypyrazolo[1,5-a]pyridine-3-carbonyl)piperazin-1-yl)-2-(3,6-dihydro-2H-pyran-4-yl)-5-ethyl-7-oxo-[1,2,4]triazolo[1,5-a]pyrimidin-4(7H)-yl)-N-(2-chloro-4-(trifluoromethyl)phenyl)acetamide::US20260015358, Example 198	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293224	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293224&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123679	381613506							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192116	CCc1c(N2CCN(C(=O)c3ncc4nc(Cl)sc4c3O)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1F	InChI=1S/C32H28ClF4N9O5S/c1-2-21-24(43-7-9-44(10-8-43)28(49)23-25(48)26-20(14-38-23)40-30(33)52-26)29(50)46-31(41-27(42-46)16-5-11-51-12-6-16)45(21)15-22(47)39-19-4-3-17(13-18(19)34)32(35,36)37/h3-5,13-14,48H,2,6-12,15H2,1H3,(H,39,47)	GUPLMPLNVROOHW-UHFFFAOYSA-N	293225	2-(6-(4-(2-Chloro-7-hydroxythiazolo[4,5-c]pyridine-6-carbonyl)piperazin-1-yl)-2-(3,6-dihydro-2H-pyran-4-yl)-5-ethyl-7-oxo-[1,2,4]triazolo[1,5-a]pyrimidin-4(7H)-yl)-N-(2-fluoro-4-(trifluoromethyl)phenyl)acetamide::US20260015358, Example 199	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293225	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293225&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123008	381613507							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192117	CCc1c(N2CCN(C(=O)c3ccn4nccc4c3O)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C33H31ClF3N9O5/c1-2-24-27(42-11-13-43(14-12-42)30(49)21-6-10-45-25(28(21)48)5-9-38-45)31(50)46-32(40-29(41-46)19-7-15-51-16-8-19)44(24)18-26(47)39-23-4-3-20(17-22(23)34)33(35,36)37/h3-7,9-10,17,48H,2,8,11-16,18H2,1H3,(H,39,47)	JVYADKJLFXWYEK-UHFFFAOYSA-N	293226	US20260015358, Example 200	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293226	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293226&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123706	381613508							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192118	CCc1c(N2CCN(C(=O)c3cnn4cncc4c3O)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C32H30ClF3N10O5/c1-2-23-26(42-7-9-43(10-8-42)29(49)20-14-38-45-17-37-15-24(45)27(20)48)30(50)46-31(40-28(41-46)18-5-11-51-12-6-18)44(23)16-25(47)39-22-4-3-19(13-21(22)33)32(34,35)36/h3-5,13-15,17,48H,2,6-12,16H2,1H3,(H,39,47)	VIJINQPYLBSGGK-UHFFFAOYSA-N	293227	US20260015358, Example 201	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293227	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293227&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123379	381613509							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192119	CCc1c(N2CCN(C(=O)c3ncn4cccc4c3O)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C33H31ClF3N9O5/c1-2-23-27(42-10-12-43(13-11-42)30(49)26-28(48)24-4-3-9-44(24)18-38-26)31(50)46-32(40-29(41-46)19-7-14-51-15-8-19)45(23)17-25(47)39-22-6-5-20(16-21(22)34)33(35,36)37/h3-7,9,16,18,48H,2,8,10-15,17H2,1H3,(H,39,47)	KHQLJLYENMLAPB-UHFFFAOYSA-N	293228	US20260015358, Example 202	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		 550							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293228	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293228&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123935	381613510							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192120	CCc1c(N2CCN(C(=O)c3ncc4ccn(C)c4c3O)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C34H33ClF3N9O5/c1-3-24-28(44-10-12-45(13-11-44)31(50)26-29(49)27-20(17-39-26)6-9-43(27)2)32(51)47-33(41-30(42-47)19-7-14-52-15-8-19)46(24)18-25(48)40-23-5-4-21(16-22(23)35)34(36,37)38/h4-7,9,16-17,49H,3,8,10-15,18H2,1-2H3,(H,40,48)	LUKRBSFXVQBMID-UHFFFAOYSA-N	293229	US20260015358, Example 203	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293229	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293229&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123552	381613511							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192121	CCc1c(N2CCN(C(=O)c3ncc4ccccc4c3O)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C35H32ClF3N8O5/c1-2-26-29(44-11-13-45(14-12-44)32(50)28-30(49)23-6-4-3-5-21(23)18-40-28)33(51)47-34(42-31(43-47)20-9-15-52-16-10-20)46(26)19-27(48)41-25-8-7-22(17-24(25)36)35(37,38)39/h3-9,17-18,49H,2,10-16,19H2,1H3,(H,41,48)	CILNYDVRUVXBNO-UHFFFAOYSA-N	293230	US20260015358, Example 204	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293230	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293230&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123428	381613512							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192122	CCc1c(N2CCN(C(=O)c3ncc4c(ccn4C)c3O)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C34H33ClF3N9O5/c1-3-24-28(44-10-12-45(13-11-44)31(50)27-29(49)21-6-9-43(2)25(21)17-39-27)32(51)47-33(41-30(42-47)19-7-14-52-15-8-19)46(24)18-26(48)40-23-5-4-20(16-22(23)35)34(36,37)38/h4-7,9,16-17,49H,3,8,10-15,18H2,1-2H3,(H,40,48)	XINXPRPQJKIYIO-UHFFFAOYSA-N	293231	N-(2-Chloro-4-(trifluoromethyl)phenyl)-2-(2-(3,6-dihydro-2H-pyran-4-yl)-5-ethyl-6-(4-(4-hydroxy-1-methyl-1H-pyrrolo[2,3-c]pyridine-5-carbonyl)piperazin-1-yl)-7-oxo-[1,2,4]triazolo[1,5-a]pyrimidin-4(7H)-yl)acetamide::US20260015358, Example 205	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293231	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293231&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123223	381613513							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192123	CCc1c(N2CCN(C(=O)c3cnn4ccnc4c3O)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C32H30ClF3N10O5/c1-2-23-25(42-9-11-43(12-10-42)29(49)20-16-38-45-8-7-37-28(45)26(20)48)30(50)46-31(40-27(41-46)18-5-13-51-14-6-18)44(23)17-24(47)39-22-4-3-19(15-21(22)33)32(34,35)36/h3-5,7-8,15-16,48H,2,6,9-14,17H2,1H3,(H,39,47)	RXBFDOWEDIGNOD-UHFFFAOYSA-N	293232	US20260015358, Example 206	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293232	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293232&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123400	381613514							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192124	CCc1c(N2CCN(C(=O)C(=O)Nc3ncccn3)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C31H30ClF3N10O5/c1-2-22-24(42-10-12-43(13-11-42)28(49)26(47)40-29-36-8-3-9-37-29)27(48)45-30(39-25(41-45)18-6-14-50-15-7-18)44(22)17-23(46)38-21-5-4-19(16-20(21)32)31(33,34)35/h3-6,8-9,16H,2,7,10-15,17H2,1H3,(H,38,46)(H,36,37,40,47)	KPAAJTOCGJOTHW-UHFFFAOYSA-N	293233	US20260015358, Example 207	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		 550							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293233	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293233&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123293	381613515							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192125	CCC1=C(N2CCN(C(=O)CNc3nc(=O)c4ccccc4[nH]3)CC2)C(=O)n2nc(C3=CCOCC3)nc2C1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C36H35ClF3N9O5/c1-2-22-24(18-28(50)42-27-8-7-21(17-25(27)37)36(38,39)40)32-44-31(20-9-15-54-16-10-20)46-49(32)34(53)30(22)48-13-11-47(12-14-48)29(51)19-41-35-43-26-6-4-3-5-23(26)33(52)45-35/h3-9,17,24H,2,10-16,18-19H2,1H3,(H,42,50)(H2,41,43,45,52)	KPBSFOCMEKNFOB-UHFFFAOYSA-N	293234	US20260015358, Example 208	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293234	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293234&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123338	381613516							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192126	[2H]C([2H])(NC(=O)c1cc(NC)ccc1F)C(=O)N1CCN(c2c(CC)n(CC(=O)Nc3ccc(C(F)(F)F)cc3F)c3nc(C4=CCOCC4)nn3c2=O)CC1	InChI=1S/C35H36F5N9O5/c1-3-27-30(47-12-10-46(11-13-47)29(51)18-42-32(52)23-17-22(41-2)5-6-24(23)36)33(53)49-34(44-31(45-49)20-8-14-54-15-9-20)48(27)19-28(50)43-26-7-4-21(16-25(26)37)35(38,39)40/h4-8,16-17,41H,3,9-15,18-19H2,1-2H3,(H,42,52)(H,43,50)/i18D2	VAOPDXOVFCMFJV-CPLZMPMBSA-N	293235	US20260015358, Example 209	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293235	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293235&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123042	381613517							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192127	CCC1=C(N2CCN(C(=O)CNC(=O)c3nncc(C)c3O)CC2)C(=O)n2nc(C3=CCOCC3)nc2C1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C34H35ClF3N9O6/c1-3-21-22(15-25(48)41-24-5-4-20(14-23(24)35)34(36,37)38)31-42-30(19-6-12-53-13-7-19)44-47(31)33(52)28(21)46-10-8-45(9-11-46)26(49)17-39-32(51)27-29(50)18(2)16-40-43-27/h4-6,14,16,22H,3,7-13,15,17H2,1-2H3,(H,39,51)(H,40,50)(H,41,48)	FTJSZTWZUZLEAN-UHFFFAOYSA-N	293236	US20260015358, Example 210	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293236	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293236&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123289	381613518							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192128	CCc1c(N2CCN(C(=O)CNC(=O)c3cccc(F)c3O)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C34H33ClF4N8O6/c1-2-25-28(45-12-10-44(11-13-45)27(49)17-40-31(51)21-4-3-5-23(36)29(21)50)32(52)47-33(42-30(43-47)19-8-14-53-15-9-19)46(25)18-26(48)41-24-7-6-20(16-22(24)35)34(37,38)39/h3-8,16,50H,2,9-15,17-18H2,1H3,(H,40,51)(H,41,48)	IZOXNKWHWYFAKH-UHFFFAOYSA-N	293237	N-(2-(4-(4-(2-((2-Chloro-4- (trifluoromethyl)phenyl)amino)-2- oxoethyl)-2-(3,6-dihydro-2H- pyran-4-yl)-5-ethyl-7-oxo-4,7- dihydro-[1,2,4]triazolo[1,5- a]pyrimidin-6-yl)piperazin-1-yl)-2- oxoethyl)-3-fluoro-2- hydroxybenzamide::US20260015358, Example 211	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293237	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293237&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123588	381613519							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192129	CCc1c(N2CCN(C(=O)CNC(=O)c3cc(N(C)C)ccc3F)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C36H38ClF4N9O5/c1-4-28-31(48-13-11-47(12-14-48)30(52)19-42-33(53)24-18-23(46(2)3)6-7-26(24)38)34(54)50-35(44-32(45-50)21-9-15-55-16-10-21)49(28)20-29(51)43-27-8-5-22(17-25(27)37)36(39,40)41/h5-9,17-18H,4,10-16,19-20H2,1-3H3,(H,42,53)(H,43,51)	OEYYVOQJQPNHBL-UHFFFAOYSA-N	293238	N-(2-(4-(4-(2-((2-Chloro-4- (trifluoromethyl)phenyl)amino)-2- oxoethyl)-2-(3,6-dihydro-2H- pyran-4-yl)-5-ethyl-7-oxo-4,7- dihydro-[1,2,4]triazolo[1,5- a]pyrimidin-6-yl)piperazin-1-yl)-2- oxoethyl)-5-(dimethylamino)-2- fluorobenzamide::US20260015358, Example 212	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		 550							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293238	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293238&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123812	381613520							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192130	CCc1c(N2CCN(C(=O)CNC(=O)c3cc(NC)c(F)cc3F)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1F	InChI=1S/C35H35F6N9O5/c1-3-27-30(48-10-8-47(9-11-48)29(52)17-43-32(53)21-15-26(42-2)24(38)16-22(21)36)33(54)50-34(45-31(46-50)19-6-12-55-13-7-19)49(27)18-28(51)44-25-5-4-20(14-23(25)37)35(39,40)41/h4-6,14-16,42H,3,7-13,17-18H2,1-2H3,(H,43,53)(H,44,51)	CLMPJBSYGXFXMY-UHFFFAOYSA-N	293239	N-(2-(4-(2-(3,6-Dihydro-2H-pyran- 4-yl)-5-ethyl-4-(2-((2-fluoro-4- (trifluoromethyl)phenyl)amino)-2- oxoethyl)-7-oxo-4,7-dihydro- [1,2,4]triazolo[1,5-a]pyrimidin-6- yl)piperazin-1-yl)-2-oxoethyl)-2,4- difluoro-5- (methylamino)benzamide::US20260015358, Example 213	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293239	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293239&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123344	381613521							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192131	CCc1c(N2CCN(C(=O)CNC(=O)c3ccc(F)c(F)c3O)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1F	InChI=1S/C34H32F6N8O6/c1-2-24-28(46-11-9-45(10-12-46)26(50)16-41-31(52)20-4-5-21(35)27(37)29(20)51)32(53)48-33(43-30(44-48)18-7-13-54-14-8-18)47(24)17-25(49)42-23-6-3-19(15-22(23)36)34(38,39)40/h3-7,15,51H,2,8-14,16-17H2,1H3,(H,41,52)(H,42,49)	UAQGOVHUVBENHN-UHFFFAOYSA-N	293240	N-(2-(4-(2-(3,6-Dihydro-2H-pyran- 4-yl)-5-ethyl-4-(2-((2-fluoro-4- (trifluoromethyl)phenyl)amino)-2- oxoethyl)-7-oxo-4,7-dihydro- [1,2,4]triazolo[1,5-a]pyrimidin-6- yl)piperazin-1-yl)-2-oxoethyl)-3,4- difluoro-2-hydroxybenzamide::US20260015358, Example 214	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293240	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293240&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123851	381613522							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192132	CCc1c(N2CCN(C(=O)CNC(=O)c3cc(NC)ccc3F)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1F	InChI=1S/C35H36F5N9O5/c1-3-27-30(47-12-10-46(11-13-47)29(51)18-42-32(52)23-17-22(41-2)5-6-24(23)36)33(53)49-34(44-31(45-49)20-8-14-54-15-9-20)48(27)19-28(50)43-26-7-4-21(16-25(26)37)35(38,39)40/h4-8,16-17,41H,3,9-15,18-19H2,1-2H3,(H,42,52)(H,43,50)	VAOPDXOVFCMFJV-UHFFFAOYSA-N	293241	N-(2-(4-(2-(3,6-dihydro-2H-pyran- 4-yl)-5-ethyl-4-(2-((2-fluoro-4- (trifluoromethyl)phenyl)amino)-2- oxoethyl)-7-oxo-4,7-dihydro- [1,2,4]triazolo[1,5-a]pyrimidin-6- yl)piperazin-1-yl)-2-oxoethyl)-2- fluoro-5-(methylamino)benzamide::US20260015358, Example 215	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293241	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293241&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123969	381613523							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192133	CCc1c(N2CCN(C(=O)CNC(=O)c3nccs3)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1F	InChI=1S/C31H31F4N9O5S/c1-2-22-25(42-10-8-41(9-11-42)24(46)16-37-27(47)28-36-7-14-50-28)29(48)44-30(39-26(40-44)18-5-12-49-13-6-18)43(22)17-23(45)38-21-4-3-19(15-20(21)32)31(33,34)35/h3-5,7,14-15H,2,6,8-13,16-17H2,1H3,(H,37,47)(H,38,45)	RJOHDWNLAFUCCC-UHFFFAOYSA-N	293242	N-(2-(4-(2-(3,6-Dihydro-2H-pyran- 4-yl)-5-ethyl-4-(2-((2-fluoro-4- (trifluoromethyl)phenyl)amino)-2- oxoethyl)-7-oxo-4,7-dihydro- [1,2,4]triazolo[1,5-a]pyrimidin-6- yl)piperazin-1-yl)-2- oxoethyl)thiazole-2-carboxamide::US20260015358, Example 216	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293242	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293242&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123061	381613524							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192134	CCC1=C(N2CCN(C(=O)CNC(=O)c3ncco3)CC2)C(=O)n2nc(C3=CCOCC3)nc2C1CC(=O)Nc1ccc(C(F)(F)F)cc1F	InChI=1S/C32H32F4N8O6/c1-2-20-21(16-24(45)39-23-4-3-19(15-22(23)33)32(34,35)36)28-40-27(18-5-12-49-13-6-18)41-44(28)31(48)26(20)43-10-8-42(9-11-43)25(46)17-38-29(47)30-37-7-14-50-30/h3-5,7,14-15,21H,2,6,8-13,16-17H2,1H3,(H,38,47)(H,39,45)	FFCVYHKIRVVRHS-UHFFFAOYSA-N	293243	N-(2-(4-(2-(3,6-Dihydro-2H-pyran- 4-yl)-5-ethyl-4-(2-((2-fluoro-4- (trifluoromethyl)phenyl)amino)-2- oxoethyl)-7-oxo-4,7-dihydro- [1,2,4]triazolo[1,5-a]pyrimidin-6- yl)piperazin-1-yl)-2- oxoethyl)oxazole-2-carboxamide::US20260015358, Example 217	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293243	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293243&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123752	381613525							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192135	CCC1=C(N2CCN(C(=O)CNC(=O)c3cc(C)on3)CC2)C(=O)n2nc(C3=CCOCC3)nc2C1CC(=O)Nc1ccc(C(F)(F)F)cc1F	InChI=1S/C33H34F4N8O6/c1-3-21-22(16-26(46)39-24-5-4-20(15-23(24)34)33(35,36)37)30-40-29(19-6-12-50-13-7-19)41-45(30)32(49)28(21)44-10-8-43(9-11-44)27(47)17-38-31(48)25-14-18(2)51-42-25/h4-6,14-15,22H,3,7-13,16-17H2,1-2H3,(H,38,48)(H,39,46)	ZXGDZDBTWUUCLY-UHFFFAOYSA-N	293244	N-(2-(4-(2-(3,6-Dihydro-2H-pyran- 4-yl)-5-ethyl-4-(2-((2-fluoro-4- (trifluoromethyl)phenyl)amino)-2- oxoethyl)-7-oxo-4,7-dihydro- [1,2,4]triazolo[1,5-a]pyrimidin-6- yl)piperazin-1-yl)-2-oxoethyl)-5- methylisoxazole-3-carboxamide::US20260015358, Example 218	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293244	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293244&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123651	381613526							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192136	CCC1=C(N2CCN(C(=O)CNC(=O)c3ccns3)CC2)C(=O)n2nc(C3=CCOCC3)nc2C1CC(=O)Nc1ccc(C(F)(F)F)cc1F	InChI=1S/C32H32F4N8O5S/c1-2-20-21(16-25(45)39-23-4-3-19(15-22(23)33)32(34,35)36)29-40-28(18-6-13-49-14-7-18)41-44(29)31(48)27(20)43-11-9-42(10-12-43)26(46)17-37-30(47)24-5-8-38-50-24/h3-6,8,15,21H,2,7,9-14,16-17H2,1H3,(H,37,47)(H,39,45)	YQLPMQQATGLEAJ-UHFFFAOYSA-N	293245	N-(2-(4-(2-(3,6-Dihydro-2H-pyran- 4-yl)-5-ethyl-4-(2-((2-fluoro-4- (trifluoromethyl)phenyl)amino)-2- oxoethyl)-7-oxo-4,7-dihydro- [1,2,4]triazolo[1,5-a]pyrimidin-6- yl)piperazin-1-yl)-2- oxoethyl)isothiazole-5-carboxamide::US20260015358, Example 219	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293245	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293245&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123870	381613527							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192137	CCC1=C(N2CCN(C(=O)CNC(=O)c3ccno3)CC2)C(=O)n2nc(C3=CCOCC3)nc2C1CC(=O)Nc1ccc(C(F)(F)F)cc1F	InChI=1S/C32H32F4N8O6/c1-2-20-21(16-25(45)39-23-4-3-19(15-22(23)33)32(34,35)36)29-40-28(18-6-13-49-14-7-18)41-44(29)31(48)27(20)43-11-9-42(10-12-43)26(46)17-37-30(47)24-5-8-38-50-24/h3-6,8,15,21H,2,7,9-14,16-17H2,1H3,(H,37,47)(H,39,45)	NTIFGCDYHPFITL-UHFFFAOYSA-N	293246	N-(2-(4-(2-(3,6-Dihydro-2H-pyran- 4-yl)-5-ethyl-4-(2-((2-fluoro-4- (trifluoromethyl)phenyl)amino)-2- oxoethyl)-7-oxo-4,7-dihydro- [1,2,4]triazolo[1,5-a]pyrimidin-6- yl)piperazin-1-yl)-2- oxoethyl)isoxazole-5-carboxamide::US20260015358, Example 220	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293246	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293246&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123495	381613528							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192138	CCC1=C(N2CCN(C(=O)CNC(=O)c3ccon3)CC2)C(=O)n2nc(C3=CCOCC3)nc2C1CC(=O)Nc1ccc(C(F)(F)F)cc1F	InChI=1S/C32H32F4N8O6/c1-2-20-21(16-25(45)38-23-4-3-19(15-22(23)33)32(34,35)36)29-39-28(18-5-12-49-13-6-18)40-44(29)31(48)27(20)43-10-8-42(9-11-43)26(46)17-37-30(47)24-7-14-50-41-24/h3-5,7,14-15,21H,2,6,8-13,16-17H2,1H3,(H,37,47)(H,38,45)	CIXDLKAAMAEIRW-UHFFFAOYSA-N	293247	N-(2-(4-(2-(3,6-Dihydro-2H-pyran- 4-yl)-5-ethyl-4-(2-((2-fluoro-4- (trifluoromethyl)phenyl)amino)-2- oxoethyl)-7-oxo-4,7-dihydro- [1,2,4]triazolo[1,5-a]pyrimidin-6- yl)piperazin-1-yl)-2- oxoethyl)isoxazole-3-carboxamide::US20260015358, Example 221	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293247	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293247&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123917	381613529							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192139	CCC1=C(N2CCN(C(=O)CNC(=O)c3nncc(C)c3O)CC2)C(=O)n2nc(C3=CCOCC3)nc2C1CC(=O)Nc1ccc(C(F)(F)F)cc1F	InChI=1S/C34H35F4N9O6/c1-3-21-22(15-25(48)41-24-5-4-20(14-23(24)35)34(36,37)38)31-42-30(19-6-12-53-13-7-19)44-47(31)33(52)28(21)46-10-8-45(9-11-46)26(49)17-39-32(51)27-29(50)18(2)16-40-43-27/h4-6,14,16,22H,3,7-13,15,17H2,1-2H3,(H,39,51)(H,40,50)(H,41,48)	HRBIZYSPWRCLAZ-UHFFFAOYSA-N	293248	N-(2-(4-(2-(3,6-Dihydro-2H-pyran- 4-yl)-5-ethyl-4-(2-((2-fluoro-4- (trifluoromethyl)phenyl)amino)-2- oxoethyl)-7-oxo-4,7-dihydro- [1,2,4]triazolo[1,5-a]pyrimidin-6- yl)piperazin-1-yl)-2-oxoethyl)-5- hydroxy-6-methylpyrimidine-4- carboxamide::US20260015358, Example 222	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293248	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293248&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123901	381613530							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192140	[2H]C([2H])(NC(=O)c1ccccc1F)C(=O)N1CCN(C2=C(CC)C(CC(=O)Nc3ccc(C(F)(F)F)cc3F)c3nc(C4=CCOCC4)nn3C2=O)CC1	InChI=1S/C35H34F5N7O5/c1-2-22-24(18-28(48)42-27-8-7-21(17-26(27)37)35(38,39)40)32-43-31(20-9-15-52-16-10-20)44-47(32)34(51)30(22)46-13-11-45(12-14-46)29(49)19-41-33(50)23-5-3-4-6-25(23)36/h3-9,17,24H,2,10-16,18-19H2,1H3,(H,41,50)(H,42,48)/i19D2	UHWWSJMJHXFLMR-FKUWIZNHSA-N	293249	N-(2-(4-(2-(3,6-Dihydro-2H-pyran- 4-yl)-5-ethyl-4-(2-((2-fluoro-4- (trifluoromethyl)phenyl)amino)-2- oxoethyl)-7-oxo-4,7-dihydro- [1,2,4]triazolo[1,5-a]pyrimidin-6- yl)piperazin-1-yl)-2-oxoethyl-1,1- d2)-2-fluorobenzamide::US20260015358, Example 223	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293249	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293249&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123182	381613531							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192141	CCC1=C(N2CCN(C(=O)CNC(=O)c3cc(N(C)C)ccc3F)CC2)C(=O)n2nc(C3=CCOCC3)nc2C1CC(=O)Nc1ccc(C(F)(F)F)cc1F	InChI=1S/C37H39F5N8O5/c1-4-24-25(19-30(51)44-29-8-5-22(17-28(29)39)37(40,41)42)34-45-33(21-9-15-55-16-10-21)46-50(34)36(54)32(24)49-13-11-48(12-14-49)31(52)20-43-35(53)26-18-23(47(2)3)6-7-27(26)38/h5-9,17-18,25H,4,10-16,19-20H2,1-3H3,(H,43,53)(H,44,51)	MPQCCNYOHVKIQS-UHFFFAOYSA-N	293250	N-(2-(4-(2-(3,6-Dihydro-2H-pyran- 4-yl)-5-ethyl-4-(2-((2-fluoro-4- (trifluoromethyl)phenyl)amino)-2- oxoethyl)-7-oxo-4,7-dihydro- [1,2,4]triazolo[1,5-a]pyrimidin-6- yl)piperazin-1-yl)-2-oxoethyl)-5- (dimethylamino)-2- fluorobenzamide::US20260015358, Example 224	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293250	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293250&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123728	381613532							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192142	[2H]C([2H])(NC(=O)c1ccccc1F)C(=O)N1CCN(c2c(CC)n(C([2H])([2H])C(=O)Nc3ccc(C(F)(F)F)cc3F)c3nc(C4=CCOCC4)nn3c2=O)CC1	InChI=1S/C34H33F5N8O5/c1-2-26-29(45-13-11-44(12-14-45)28(49)18-40-31(50)22-5-3-4-6-23(22)35)32(51)47-33(42-30(43-47)20-9-15-52-16-10-20)46(26)19-27(48)41-25-8-7-21(17-24(25)36)34(37,38)39/h3-9,17H,2,10-16,18-19H2,1H3,(H,40,50)(H,41,48)/i18D2,19D2	PLPCXPVYAUEDKA-AUZVCRNNSA-N	293251	US20260015358, Example 225	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293251	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293251&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123356	381613533							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192143	CCc1c(N2CCN(C(=O)C(=O)Nc3ncco3)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C30H29ClF3N9O6/c1-2-21-23(40-8-10-41(11-9-40)27(47)25(45)38-28-35-7-14-49-28)26(46)43-29(37-24(39-43)17-5-12-48-13-6-17)42(21)16-22(44)36-20-4-3-18(15-19(20)31)30(32,33)34/h3-5,7,14-15H,2,6,8-13,16H2,1H3,(H,36,44)(H,35,38,45)	WJCHGOPIPVWUAS-UHFFFAOYSA-N	293252	2-(4-(4-(2-((2-Chloro-4-(trifluoromethyl)phenyl)amino)-2-oxoethyl)-2-(3,6-dihydro-2H-pyran-4-yl)-5-ethyl-7-oxo-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)piperazin-1-yl)-N-(oxazol-2-yl)-2-oxoacetamide::US20260015358, Example 226	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293252	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293252&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124122947	381613534							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192520	CCc1c(N2CCN(C(=O)C(=O)Nc3nccs3)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1F	InChI=1S/C30H29F4N9O5S/c1-2-21-23(40-8-10-41(11-9-40)27(47)25(45)38-28-35-7-14-49-28)26(46)43-29(37-24(39-43)17-5-12-48-13-6-17)42(21)16-22(44)36-20-4-3-18(15-19(20)31)30(32,33)34/h3-5,7,14-15H,2,6,8-13,16H2,1H3,(H,36,44)(H,35,38,45)	XHKKXAWOXXYRRB-UHFFFAOYSA-N	293253	2-(4-(2-(3,6-Dihydro-2H-pyran-4-yl)-5-ethyl-4-(2-((2-fluoro-4-(trifluoromethyl)phenyl)amino)-2-oxoethyl)-7-oxo-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)piperazin-1-yl)-2-oxo-N-(thiazol-2-yl)acetamide::US20260015358, Example 227	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293253	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293253&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124122979	381613535							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192521	CCc1c(N2CCN(C(=O)C(=O)Nc3ncco3)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1F	InChI=1S/C30H29F4N9O6/c1-2-21-23(40-8-10-41(11-9-40)27(47)25(45)38-28-35-7-14-49-28)26(46)43-29(37-24(39-43)17-5-12-48-13-6-17)42(21)16-22(44)36-20-4-3-18(15-19(20)31)30(32,33)34/h3-5,7,14-15H,2,6,8-13,16H2,1H3,(H,36,44)(H,35,38,45)	GZQBKFOQQCKPQX-UHFFFAOYSA-N	293254	2-(4-(2-(3,6-Dihydro-2H-pyran-4-yl)-5-ethyl-4-(2-((2-fluoro-4-(trifluoromethyl)phenyl)amino)-2-oxoethyl)-7-oxo-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)piperazin-1-yl)-N-(oxazol-2-yl)-2-oxoacetamide::US20260015358, Example 228	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293254	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293254&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123941	381613536							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192522	CCc1c(N2CCN(C(=O)C(=O)Nc3ccccn3)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1F	InChI=1S/C32H31F4N9O5/c1-2-23-26(42-11-13-43(14-12-42)30(49)28(47)39-24-5-3-4-10-37-24)29(48)45-31(40-27(41-45)19-8-15-50-16-9-19)44(23)18-25(46)38-22-7-6-20(17-21(22)33)32(34,35)36/h3-8,10,17H,2,9,11-16,18H2,1H3,(H,38,46)(H,37,39,47)	FBZXDBYCXFISLB-UHFFFAOYSA-N	293255	2-(4-(2-(3,6-Dihydro-2H-pyran-4-yl)-5-ethyl-4-(2-((2-fluoro-4-(trifluoromethyl)phenyl)amino)-2-oxoethyl)-7-oxo-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)piperazin-1-yl)-2-oxo-N-(pyridin-2-yl)acetamide::US20260015358, Example 229	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		 550							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293255	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293255&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123628	381613537							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192523	CCc1c(N2CCN(C(=O)CNC(=O)c3ccccc3)CC2)c(=O)n2nc(N3CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C33H35ClF3N9O5/c1-2-25-28(43-12-10-42(11-13-43)27(48)19-38-29(49)21-6-4-3-5-7-21)30(50)46-32(40-31(41-46)44-14-16-51-17-15-44)45(25)20-26(47)39-24-9-8-22(18-23(24)34)33(35,36)37/h3-9,18H,2,10-17,19-20H2,1H3,(H,38,49)(H,39,47)	IORNVXMBQGARKU-UHFFFAOYSA-N	293256	US20260015358, Example 231	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293256	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293256&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123125	381613538							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192524	CCc1c(N2CCN(C(=O)CNC(=O)c3ccccc3)CC2)c(=O)n2nc(N3Cc4ccncc4C3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C36H34ClF3N10O4/c1-2-28-31(47-14-12-46(13-15-47)30(52)18-42-32(53)22-6-4-3-5-7-22)33(54)50-35(44-34(45-50)48-19-23-10-11-41-17-24(23)20-48)49(28)21-29(51)43-27-9-8-25(16-26(27)37)36(38,39)40/h3-11,16-17H,2,12-15,18-21H2,1H3,(H,42,53)(H,43,51)	UHZVFWSEYUOESI-UHFFFAOYSA-N	293257	US20260015358, Example 232	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293257	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293257&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123216	381613539							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192525	CCc1c(N2CCN(C(=O)CNC(=O)c3ccccc3)CC2)c(=O)n2nc(N3Cc4ccncc4C3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C36H34ClF3N10O4/c1-2-28-31(47-14-12-46(13-15-47)30(52)18-42-32(53)22-6-4-3-5-7-22)33(54)50-35(44-34(45-50)48-19-23-10-11-41-17-24(23)20-48)49(28)21-29(51)43-27-9-8-25(16-26(27)37)36(38,39)40/h3-11,16-17H,2,12-15,18-21H2,1H3,(H,42,53)(H,43,51)	UHZVFWSEYUOESI-UHFFFAOYSA-N	293258	US20260015358, Example 233	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293258	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293258&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123421	381613540							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192526	CCc1c(N2CCN(C(=O)CNC(=O)c3ccccc3)CC2)c(=O)n2nc(N3CCc4ncccc43)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C36H34ClF3N10O4/c1-2-27-31(47-17-15-46(16-18-47)30(52)20-42-32(53)22-7-4-3-5-8-22)33(54)50-35(44-34(45-50)48-14-12-26-28(48)9-6-13-41-26)49(27)21-29(51)43-25-11-10-23(19-24(25)37)36(38,39)40/h3-11,13,19H,2,12,14-18,20-21H2,1H3,(H,42,53)(H,43,51)	HIYFUUMJSGFXGH-UHFFFAOYSA-N	293259	N-(2-(4-(4-(2-((2-Chloro-4-(trifluoromethyl)phenyl)amino)-2-oxoethyl)-2-(2,3-dihydro-1H-pyrrolo[3,2-b]pyridin-1-yl)-5-ethyl-7-oxo-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)piperazin-1-yl)-2-oxoethyl)benzamide::US20260015358, Example 234	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		 550							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293259	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293259&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			124123612	381613541							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192527	CCc1c(N2CCN(C(=O)CNC(=O)c3ccccc3)CC2)c(=O)n2nc(N3CC4(COC4)C3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C34H35ClF3N9O5/c1-2-25-28(44-12-10-43(11-13-44)27(49)15-39-29(50)21-6-4-3-5-7-21)30(51)47-32(41-31(42-47)45-17-33(18-45)19-52-20-33)46(25)16-26(48)40-24-9-8-22(14-23(24)35)34(36,37)38/h3-9,14H,2,10-13,15-20H2,1H3,(H,39,50)(H,40,48)	NZLCWCUQXBRYPB-UHFFFAOYSA-N	321416	US20260015358, Example 235	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		 550							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=321416	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=321416&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			122659500	384224505							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192528	CCc1c(N2CCN(C(=O)CNC(=O)c3ccccc3)CC2)c(=O)n2nc(-c3cnc4c(c3)CCCO4)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C37H35ClF3N9O5/c1-2-28-31(48-14-12-47(13-15-48)30(52)20-42-33(53)22-7-4-3-5-8-22)35(54)50-36(45-32(46-50)24-17-23-9-6-16-55-34(23)43-19-24)49(28)21-29(51)44-27-11-10-25(18-26(27)38)37(39,40)41/h3-5,7-8,10-11,17-19H,2,6,9,12-16,20-21H2,1H3,(H,42,53)(H,44,51)	HLIGNTYQYWURDT-UHFFFAOYSA-N	321440	US20260015358, Example 236	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		 550							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=321440	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=321440&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			122659501	384224529							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192529	CCc1c(N2CCN(C(=O)CNC(=O)c3ccccc3)CC2)c(=O)n2nc(C(C)(C)C)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C33H36ClF3N8O4/c1-5-24-27(43-15-13-42(14-16-43)26(47)18-38-28(48)20-9-7-6-8-10-20)29(49)45-31(40-30(41-45)32(2,3)4)44(24)19-25(46)39-23-12-11-21(17-22(23)34)33(35,36)37/h6-12,17H,5,13-16,18-19H2,1-4H3,(H,38,48)(H,39,46)	WLFGDOAWBSPYMP-UHFFFAOYSA-N	327826	US20260015358, Example 237	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		 550							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327826	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327826&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			25063725	384582746							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192530	CCc1c(N2CCN(C(=O)CNC(=O)c3ccccc3)CC2)c(=O)n2nc(C3CC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C32H32ClF3N8O4/c1-2-24-27(42-14-12-41(13-15-42)26(46)17-37-29(47)20-6-4-3-5-7-20)30(48)44-31(39-28(40-44)19-8-9-19)43(24)18-25(45)38-23-11-10-21(16-22(23)33)32(34,35)36/h3-7,10-11,16,19H,2,8-9,12-15,17-18H2,1H3,(H,37,47)(H,38,45)	QJQAGZZILAGJSI-UHFFFAOYSA-N	327827	US20260015358, Example 238	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		 550							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327827	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327827&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			25063327	384582747							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192531	CCOc1nc2n(CC(=O)Nc3ccc(C(F)(F)F)cc3Cl)c(CC)c(N3CCN(C(=O)CNC(=O)c4ccccc4F)CC3)c(=O)n2n1	InChI=1S/C31H31ClF4N8O5/c1-3-23-26(42-13-11-41(12-14-42)25(46)16-37-27(47)19-7-5-6-8-21(19)33)28(48)44-30(39-29(40-44)49-4-2)43(23)17-24(45)38-22-10-9-18(15-20(22)32)31(34,35)36/h5-10,15H,3-4,11-14,16-17H2,1-2H3,(H,37,47)(H,38,45)	PUTXJDBQLXGGFU-UHFFFAOYSA-N	327828	US20260015358, Example 239	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		 550							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327828	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327828&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			25063329	384582748							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192532	CCC4=C(N2CCN(C(=O)CNC(=O)c1ccccc1F)CC2)C(=O)n3nc(SC)nc3C4CC(=O)Nc5ccc(C(F)(F)F)cc5Cl	InChI=1S/C31H30ClF4N7O4S/c1-3-18-20(15-24(44)38-23-9-8-17(14-21(23)32)31(34,35)36)27-39-30(48-2)40-43(27)29(47)26(18)42-12-10-41(11-13-42)25(45)16-37-28(46)19-6-4-5-7-22(19)33/h4-9,14,20H,3,10-13,15-16H2,1-2H3,(H,37,46)(H,38,44)	PJRFSNIWCNVJSR-UHFFFAOYSA-N	327829	US20260015358, Example 241	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		 550							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327829	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327829&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			68927969	384582749							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192533	CCc1c(N2CCN(C(=O)CNC(=O)c3ccccc3F)CC2)c(=O)n2nc(N3CC(F)(F)C3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C32H30ClF6N9O4/c1-2-23-26(45-11-9-44(10-12-45)25(50)14-40-27(51)19-5-3-4-6-21(19)34)28(52)48-30(42-29(43-48)46-16-31(35,36)17-46)47(23)15-24(49)41-22-8-7-18(13-20(22)33)32(37,38)39/h3-8,13H,2,9-12,14-17H2,1H3,(H,40,51)(H,41,49)	DKPLNZGFVPBWAG-UHFFFAOYSA-N	327832	US20260015358, Example 244	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327832	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327832&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			25063368	384582750							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192534	CCc6c(N2CCN(C(=O)CNC(=O)c1ccccc1F)CC2)c(=O)n5nc(N4Cc3ccncc3C4)nc5n6CC(=O)Nc7ccc(C(F)(F)F)cc7Cl	InChI=1S/C36H33ClF4N10O4/c1-2-28-31(48-13-11-47(12-14-48)30(53)17-43-32(54)24-5-3-4-6-26(24)38)33(55)51-35(45-34(46-51)49-18-21-9-10-42-16-22(21)19-49)50(28)20-29(52)44-27-8-7-23(15-25(27)37)36(39,40)41/h3-10,15-16H,2,11-14,17-20H2,1H3,(H,43,54)(H,44,52)	OIQFIWBSAJXRDE-UHFFFAOYSA-N	327833	US20260015358, Example 246	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		 550							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327833	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327833&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			25063688	384582751							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192535	CCc1c(N2CCN(C(=O)CNC(=O)c3nccs3)CC2)c(=O)n2nc(N3CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C30H32ClF3N10O5S/c1-2-21-24(41-8-6-40(7-9-41)23(46)16-36-25(47)26-35-5-14-50-26)27(48)44-29(38-28(39-44)42-10-12-49-13-11-42)43(21)17-22(45)37-20-4-3-18(15-19(20)31)30(32,33)34/h3-5,14-15H,2,6-13,16-17H2,1H3,(H,36,47)(H,37,45)	KKBZOIGBFOCYLY-UHFFFAOYSA-N	327834	US20260015358, Example 248	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327834	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327834&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			23642333	384582752							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192536	CCc1c(N2CCN(C(=O)CNC(=O)c3ncco3)CC2)c(=O)n2nc(N3CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C30H32ClF3N10O6/c1-2-21-24(41-8-6-40(7-9-41)23(46)16-36-25(47)26-35-5-12-50-26)27(48)44-29(38-28(39-44)42-10-13-49-14-11-42)43(21)17-22(45)37-20-4-3-18(15-19(20)31)30(32,33)34/h3-5,12,15H,2,6-11,13-14,16-17H2,1H3,(H,36,47)(H,37,45)	OTLZFYJLJNCQPM-UHFFFAOYSA-N	327835	US20260015358, Example 249	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327835	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327835&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			25063410	384582753							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192537	CCc1c(N2CCN(C(=O)CNC(=O)c3cc(NC)ccc3F)CC2)c(=O)n2nc(N3CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C34H37ClF4N10O5/c1-3-26-29(46-10-8-45(9-11-46)28(51)18-41-30(52)22-17-21(40-2)5-6-24(22)36)31(53)49-33(43-32(44-49)47-12-14-54-15-13-47)48(26)19-27(50)42-25-7-4-20(16-23(25)35)34(37,38)39/h4-7,16-17,40H,3,8-15,18-19H2,1-2H3,(H,41,52)(H,42,50)	YDQNTUZYUIQVKC-UHFFFAOYSA-N	327836	US20260015358, Example 250	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327836	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327836&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			68926755	384582754							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192538	CCc1c(N2CCN(C(=O)CNC(=O)c3ccc(F)c(NC)c3)CC2)c(=O)n2nc(N3CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C34H37ClF4N10O5/c1-3-26-29(46-10-8-45(9-11-46)28(51)18-41-30(52)20-4-6-23(36)25(16-20)40-2)31(53)49-33(43-32(44-49)47-12-14-54-15-13-47)48(26)19-27(50)42-24-7-5-21(17-22(24)35)34(37,38)39/h4-7,16-17,40H,3,8-15,18-19H2,1-2H3,(H,41,52)(H,42,50)	YRQYHRDHXLPOSB-UHFFFAOYSA-N	327838	US20260015358, Example 251	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327838	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327838&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			25063444	384582755							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192539	CCc1c(N2CCN(C(=O)CNC(=O)c3cccc(O)c3F)CC2)c(=O)n2nc(N3CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1F	InChI=1S/C33H34F5N9O6/c1-2-23-28(44-10-8-43(9-11-44)26(50)17-39-29(51)20-4-3-5-24(48)27(20)35)30(52)47-32(41-31(42-47)45-12-14-53-15-13-45)46(23)18-25(49)40-22-7-6-19(16-21(22)34)33(36,37)38/h3-7,16,48H,2,8-15,17-18H2,1H3,(H,39,51)(H,40,49)	WVVAPMDNTNQBSX-UHFFFAOYSA-N	327839	US20260015358, Example 252	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327839	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327839&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			25063491	384582756							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192540	CCc1c(N2CCN(C(=O)CNC(=O)c3cc(F)cc(NC)c3)CC2)c(=O)n2nc(N3CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1F	InChI=1S/C34H37F5N10O5/c1-3-26-29(46-8-6-45(7-9-46)28(51)18-41-30(52)20-14-22(35)17-23(15-20)40-2)31(53)49-33(43-32(44-49)47-10-12-54-13-11-47)48(26)19-27(50)42-25-5-4-21(16-24(25)36)34(37,38)39/h4-5,14-17,40H,3,6-13,18-19H2,1-2H3,(H,41,52)(H,42,50)	GMLDBHHHFRBAQO-UHFFFAOYSA-N	327840	N-(2-(4-(5-Ethyl-4-(2-((2-fluoro-4-(trifluoromethyl)phenyl)amino)-2-oxoethyl)-2-morpholino-7-oxo-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)piperazin-1-yl)-2-oxoethyl)-3-fluoro-5-(methylamino)benzamide::US20260015358, Example 253	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327840	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327840&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			25063691	384582757							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192541	CCc1c(N2CCN(C(=O)CNC(=O)c3ccccc3F)CC2)c(=O)n2nc(N3CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1F	InChI=1S/C33H34F5N9O5/c1-2-25-28(44-11-9-43(10-12-44)27(49)18-39-29(50)21-5-3-4-6-22(21)34)30(51)47-32(41-31(42-47)45-13-15-52-16-14-45)46(25)19-26(48)40-24-8-7-20(17-23(24)35)33(36,37)38/h3-8,17H,2,9-16,18-19H2,1H3,(H,39,50)(H,40,48)	QARLPFLBOLUFOX-UHFFFAOYSA-N	327841	US20260015358, Example 254	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327841	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327841&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			68997427	384582758							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192542	CCc1c(N2CCN(C(=O)CNC(=O)c3cccc(F)c3N)CC2)c(=O)n2nc(N3CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1F	InChI=1S/C33H35F5N10O5/c1-2-24-28(45-10-8-44(9-11-45)26(50)17-40-29(51)20-4-3-5-21(34)27(20)39)30(52)48-32(42-31(43-48)46-12-14-53-15-13-46)47(24)18-25(49)41-23-7-6-19(16-22(23)35)33(36,37)38/h3-7,16H,2,8-15,17-18,39H2,1H3,(H,40,51)(H,41,49)	JWYYMIYHZYUWPS-UHFFFAOYSA-N	327842	2-Amino-N-(2-(4-(5-Ethyl-4-(2-((2-fluoro-4-(trifluoromethyl)phenyl)amino)-2-oxoethyl)-2-morpholino-7-oxo-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)piperazin-1-yl)-2-oxoethyl)-3-fluorobenzamide::US20260015358, Example 255	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327842	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327842&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			25063535	384582759							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192543	CCc1c(N2CCN(C(=O)CNC(=O)c3ccc(F)c(NC)c3)CC2)c(=O)n2nc(N3CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1F	InChI=1S/C34H37F5N10O5/c1-3-26-29(46-10-8-45(9-11-46)28(51)18-41-30(52)20-4-6-22(35)25(16-20)40-2)31(53)49-33(43-32(44-49)47-12-14-54-15-13-47)48(26)19-27(50)42-24-7-5-21(17-23(24)36)34(37,38)39/h4-7,16-17,40H,3,8-15,18-19H2,1-2H3,(H,41,52)(H,42,50)	HOQKXTOBNVMRLN-UHFFFAOYSA-N	327843	US20260015358, Example 256	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327843	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327843&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			25063653	384582760							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192544	CCc1c(N2CCN(C(=O)CNC(=O)c3ncco3)CC2)c(=O)n2nc(N3CCCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1F	InChI=1S/C31H34F4N10O6/c1-2-22-25(42-10-8-41(9-11-42)24(47)17-37-26(48)27-36-6-14-51-27)28(49)45-30(39-29(40-45)43-7-3-13-50-15-12-43)44(22)18-23(46)38-21-5-4-19(16-20(21)32)31(33,34)35/h4-6,14,16H,2-3,7-13,15,17-18H2,1H3,(H,37,48)(H,38,46)	AZZWXDLDVZPNLR-UHFFFAOYSA-N	327844	US20260015358, Example 257	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		 550							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327844	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327844&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			57682603	384582761							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192545	CCc1c(N2CCN(C(=O)C(=O)Nc3nccs3)CC2)c(=O)n2nc(N3CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C29H30ClF3N10O5S/c1-2-20-22(39-6-8-40(9-7-39)25(47)23(45)36-27-34-5-14-49-27)24(46)43-28(37-26(38-43)41-10-12-48-13-11-41)42(20)16-21(44)35-19-4-3-17(15-18(19)30)29(31,32)33/h3-5,14-15H,2,6-13,16H2,1H3,(H,35,44)(H,34,36,45)	BWFQZACGVARDIM-UHFFFAOYSA-N	327845	2-(4-(4-(2-((2-Chloro-4-(trifluoromethyl)phenyl)amino)-2-oxoethyl)-5-ethyl-2-morpholino-7-oxo-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)piperazin-1-yl)-2-oxo-N-(thiazol-2-yl)acetamide::US20260015358, Example 258	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327845	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327845&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			25063614	384582762							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192546	CCc1c(N2CCN(C(=O)C(=O)Nc3nccs3)CC2)c(=O)n2nc(N3Cc4ccncc4C3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C32H29ClF3N11O4S/c1-2-23-25(43-8-10-44(11-9-43)28(51)26(49)40-30-38-7-12-52-30)27(50)47-31(41-29(42-47)45-15-18-5-6-37-14-19(18)16-45)46(23)17-24(48)39-22-4-3-20(13-21(22)33)32(34,35)36/h3-7,12-14H,2,8-11,15-17H2,1H3,(H,39,48)(H,38,40,49)	OQTQXHPMSTXIOH-UHFFFAOYSA-N	332546	2-(4-(4-(2-((2-Chloro-4-(trifluoromethyl)phenyl)amino)-2-oxoethyl)-2-(1,3-dihydro-2H-pyrrolo[3,4-c]pyridin-2-yl)-5-ethyl-7-oxo-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)piperazin-1-yl)-2-oxo-N-(thiazol-2-yl)acetamide::US20260015358, Example 259	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		 550							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332546	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332546&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			91667585	384577260							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192547	CCc1c(N2CCN(C(=O)C(=O)Nc3nccs3)CC2)c(=O)n2nc(N3CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1F	InChI=1S/C29H30F4N10O5S/c1-2-20-22(39-6-8-40(9-7-39)25(47)23(45)36-27-34-5-14-49-27)24(46)43-28(37-26(38-43)41-10-12-48-13-11-41)42(20)16-21(44)35-19-4-3-17(15-18(19)30)29(31,32)33/h3-5,14-15H,2,6-13,16H2,1H3,(H,35,44)(H,34,36,45)	PUBKPOHOVHJMFO-UHFFFAOYSA-N	332547	2-(4-(5-Ethyl-4-(2-((2-fluoro-4-(trifluoromethyl)phenyl)amino)-2-oxoethyl)-2-morpholino-7-oxo-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)piperazin-1-yl)-2-oxo-N-(thiazol-2-yl)acetamide::US20260015358, Example 260	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332547	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332547&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			117979121	384577261							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192548	CCc1c(N2CCN(C(=O)C(=O)Nc3nccs3)CC2)c(=O)n2nc(N3CCn4cncc4C3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1F	InChI=1S/C31H30F4N12O4S/c1-2-22-24(42-6-8-43(9-7-42)27(51)25(49)39-29-37-5-12-52-29)26(50)47-30(40-28(41-47)44-10-11-45-17-36-14-19(45)15-44)46(22)16-23(48)38-21-4-3-18(13-20(21)32)31(33,34)35/h3-5,12-14,17H,2,6-11,15-16H2,1H3,(H,38,48)(H,37,39,49)	NIEWJVYNFPVCFI-UHFFFAOYSA-N	332548	2-(4-(2-(5,6-Dihydroimidazo[1,5-a]pyrazin-7(8H)-yl)-5-ethyl-4-(2-((2-fluoro-4-(trifluoromethyl)phenyl)amino)-2-oxoethyl)-7-oxo-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)piperazin-1-yl)-2-oxo-N-(thiazol-2-yl)acetamide::US20260015358, Example 261	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332548	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332548&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			117978836	384577262							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192549	CCc1c(N2CCN(C(=O)C(=O)Nc3nccs3)CC2)c(=O)n2nc(N3CCCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1F	InChI=1S/C30H32F4N10O5S/c1-2-21-23(40-8-10-41(11-9-40)26(48)24(46)37-28-35-6-15-50-28)25(47)44-29(38-27(39-44)42-7-3-13-49-14-12-42)43(21)17-22(45)36-20-5-4-18(16-19(20)31)30(32,33)34/h4-6,15-16H,2-3,7-14,17H2,1H3,(H,36,45)(H,35,37,46)	QQVZIWBAEGBZSA-UHFFFAOYSA-N	332549	2-(4-(5-Ethyl-4-(2-((2-fluoro-4-(trifluoromethyl)phenyl)amino)-2-oxoethyl)-2-(1,4-oxazepan-4-yl)-7-oxo-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)piperazin-1-yl)-2-oxo-N-(thiazol-2-yl)acetamide::US20260015358, Example 262	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		 550							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332549	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332549&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			117979044	384577263							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192550	CCc1c(N2CCN(C(=O)CNC(=O)c3ccccc3F)CC2)c(=O)n2nc(N3Cc4cnn(C)c4C3)nc2n1CC(=O)Nc1cc(C)cs1	InChI=1S/C33H36FN11O4S/c1-4-24-29(42-11-9-41(10-12-42)28(47)15-35-30(48)22-7-5-6-8-23(22)34)31(49)45-33(44(24)18-26(46)37-27-13-20(2)19-50-27)38-32(39-45)43-16-21-14-36-40(3)25(21)17-43/h5-8,13-14,19H,4,9-12,15-18H2,1-3H3,(H,35,48)(H,37,46)	QGHYGTKEDQIZNJ-UHFFFAOYSA-N	332550	US20260015358, Example 263	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332550	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332550&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			117979008	384577264							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192551	CCc1c(N2CCN(C(=O)C(=O)Nc3nccs3)CC2)c(=O)n2nc(N3CCN4C(=O)OC[C@H]4C3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1F	InChI=1S/C31H31F4N11O6S/c1-2-21-23(41-6-8-42(9-7-41)26(50)24(48)38-28-36-5-12-53-28)25(49)46-29(39-27(40-46)43-10-11-44-18(14-43)16-52-30(44)51)45(21)15-22(47)37-20-4-3-17(13-19(20)32)31(33,34)35/h3-5,12-13,18H,2,6-11,14-16H2,1H3,(H,37,47)(H,36,38,48)	BKQMFHMEJYKVOQ-UHFFFAOYSA-N	332551	US20260015358, Example 264	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332551	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332551&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			117979089	384577265							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192552	CCc1c(N2CCN(C(=O)CNC(=O)NC(=O)c3cc(F)ccc3F)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C35H33ClF5N9O6/c1-2-26-29(48-11-9-47(10-12-48)28(52)17-42-33(55)45-31(53)22-16-21(37)4-5-24(22)38)32(54)50-34(44-30(46-50)19-7-13-56-14-8-19)49(26)18-27(51)43-25-6-3-20(15-23(25)36)35(39,40)41/h3-7,15-16H,2,8-14,17-18H2,1H3,(H,43,51)(H2,42,45,53,55)	WMCCQZQGQIWQJH-UHFFFAOYSA-N	332552	US20260015358, Example 265	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332552	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332552&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			117979145	384577266							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192553	CCc1c(N2CCN(C(=O)c3cnc4ccccc4c3O)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C35H32ClF3N8O5/c1-2-27-29(44-11-13-45(14-12-44)32(50)23-18-40-25-6-4-3-5-22(25)30(23)49)33(51)47-34(42-31(43-47)20-9-15-52-16-10-20)46(27)19-28(48)41-26-8-7-21(17-24(26)36)35(37,38)39/h3-9,17-18H,2,10-16,19H2,1H3,(H,40,49)(H,41,48)	HYJUINFERHFOMU-UHFFFAOYSA-N	332553	US20260015358, Example 266	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332553	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332553&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			117979114	384577267							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192554	CCc1c(N2CCN(C(=O)CNC(=O)Cc3ccccc3)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C35H36ClF3N8O5/c1-2-27-31(45-14-12-44(13-15-45)30(50)20-40-28(48)18-22-6-4-3-5-7-22)33(51)47-34(42-32(43-47)23-10-16-52-17-11-23)46(27)21-29(49)41-26-9-8-24(19-25(26)36)35(37,38)39/h3-10,19H,2,11-18,20-21H2,1H3,(H,40,48)(H,41,49)	ODZHDXMPPXRLJB-UHFFFAOYSA-N	332554	US20260015358, Example 267	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332554	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332554&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			117978833	384577268							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192555	CCc1c(N2CCN(C(=O)CNC(=O)c3cncs3)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C31H31ClF3N9O5S/c1-2-22-26(42-9-7-41(8-10-42)25(46)15-37-28(47)23-14-36-17-50-23)29(48)44-30(39-27(40-44)18-5-11-49-12-6-18)43(22)16-24(45)38-21-4-3-19(13-20(21)32)31(33,34)35/h3-5,13-14,17H,2,6-12,15-16H2,1H3,(H,37,47)(H,38,45)	KNJNMLGKVRQHRV-UHFFFAOYSA-N	332555	N-(2-(4-(4-(2-((2-Chloro-4- (trifluoromethyl)phenyl)amino)-2- oxoethyl)-2-(3,6-dihydro-2H- pyran-4-yl)-5-ethyl-7-oxo-4,7- dihydro-[1,2,4]triazolo[1,5- a]pyrimidin-6-yl)piperazin-1-yl)-2- oxoethyl)thiazole-5-carboxamide::US20260015358, Example 268	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332555	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332555&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			117979151	384577269							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192556	CCc1c(N2CCN(C(=O)CNC(=O)c3ccccc3O)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C34H34ClF3N8O6/c1-2-25-29(44-13-11-43(12-14-44)28(49)18-39-31(50)22-5-3-4-6-26(22)47)32(51)46-33(41-30(42-46)20-9-15-52-16-10-20)45(25)19-27(48)40-24-8-7-21(17-23(24)35)34(36,37)38/h3-9,17,47H,2,10-16,18-19H2,1H3,(H,39,50)(H,40,48)	XJGWOCYNOSSHOR-UHFFFAOYSA-N	332556	N-(2-(4-(4-(2-((2-Chloro-4- (trifluoromethyl)phenyl)amino)-2- oxoethyl)-2-(3,6-dihydro-2H- pyran-4-yl)-5-ethyl-7-oxo-4,7- dihydro-[1,2,4]triazolo[1,5- a]pyrimidin-6-yl)piperazin-1-yl)-2- oxoethyl)-2-hydroxybenzamide::US20260015358, Example 269	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332556	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332556&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			117979176	384577270							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192557	CCc1c(N2CCN(C(=O)CNC(=O)c3cccc(O)c3)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C34H34ClF3N8O6/c1-2-26-29(44-12-10-43(11-13-44)28(49)18-39-31(50)21-4-3-5-23(47)16-21)32(51)46-33(41-30(42-46)20-8-14-52-15-9-20)45(26)19-27(48)40-25-7-6-22(17-24(25)35)34(36,37)38/h3-8,16-17,47H,2,9-15,18-19H2,1H3,(H,39,50)(H,40,48)	ADHFTHCUNLCQJF-UHFFFAOYSA-N	332557	N-(2-(4-(4-(2-((2-Chloro-4- (trifluoromethyl)phenyl)amino)-2- oxoethyl)-2-(3,6-dihydro-2H- pyran-4-yl)-5-ethyl-7-oxo-4,7- dihydro-[1,2,4]triazolo[1,5- a]pyrimidin-6-yl)piperazin-1-yl)-2- oxoethyl)-3-hydroxybenzamide::US20260015358, Example 270	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332557	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332557&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			117979068	384577271							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192558	CCc1c(N2CCN(C(=O)CNC(=O)c3ncccc3O)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C33H33ClF3N9O6/c1-2-23-28(44-12-10-43(11-13-44)26(49)17-39-30(50)27-24(47)4-3-9-38-27)31(51)46-32(41-29(42-46)19-7-14-52-15-8-19)45(23)18-25(48)40-22-6-5-20(16-21(22)34)33(35,36)37/h3-7,9,16,47H,2,8,10-15,17-18H2,1H3,(H,39,50)(H,40,48)	DEDGTARZLOXLKM-UHFFFAOYSA-N	332558	N-(2-(4-(4-(2-((2-Chloro-4- (trifluoromethyl)phenyl)amino)-2- oxoethyl)-2-(3,6-dihydro-2H- pyran-4-yl)-5-ethyl-7-oxo-4,7- dihydro-[1,2,4]triazolo[1,5- a]pyrimidin-6-yl)piperazin-1-yl)-2- oxoethyl)-3-hydroxypicolinamide::US20260015358, Example 271	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		 550							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332558	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332558&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			117978842	384577272							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192559	CCc1c(N2CCN(C(=O)CNC(=O)CC3CCC3)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C33H38ClF3N8O5/c1-2-25-29(43-12-10-42(11-13-43)28(48)18-38-26(46)16-20-4-3-5-20)31(49)45-32(40-30(41-45)21-8-14-50-15-9-21)44(25)19-27(47)39-24-7-6-22(17-23(24)34)33(35,36)37/h6-8,17,20H,2-5,9-16,18-19H2,1H3,(H,38,46)(H,39,47)	NKAKUOKHTOQPKG-UHFFFAOYSA-N	332559	N-(2-Chloro-4- (trifluoromethyl)phenyl)-2-(6-(4- ((2- cyclobutylacetyl)glycyl)piperazin- 1-yl)-2-(3,6-dihydro-2H-pyran-4- yl)-5-ethyl-7-oxo- [1,2,4]triazolo[1,5-a]pyrimidin- 4(7H)-yl)acetamide::US20260015358, Example 272	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332559	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332559&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			121425301	384577273							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192560	CCc1c(N2CCN(C(=O)CNC(=O)CC3COC3)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C32H36ClF3N8O6/c1-2-24-28(42-9-7-41(8-10-42)27(47)15-37-25(45)13-19-17-50-18-19)30(48)44-31(39-29(40-44)20-5-11-49-12-6-20)43(24)16-26(46)38-23-4-3-21(14-22(23)33)32(34,35)36/h3-5,14,19H,2,6-13,15-18H2,1H3,(H,37,45)(H,38,46)	HLSBUMOIRVJKLJ-UHFFFAOYSA-N	332560	N-(2-Chloro-4- (trifluoromethyl)phenyl)-2-(2-(3,6- dihydro-2H-pyran-4-yl)-5-ethyl-6- (4-((2-(oxetan-3- yl)acetyl)glycyl)piperazin-1-yl)-7- oxo-[1,2,4]triazolo[1,5- a]pyrimidin-4(7H)-yl)acetamide::US20260015358, Example 273	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		 550							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332560	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332560&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			121425303	384577274							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192561	CCc1c(N2CCN(C(=O)CNC(=O)Cc3ccccc3F)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C35H35ClF4N8O5/c1-2-27-31(46-13-11-45(12-14-46)30(51)19-41-28(49)17-22-5-3-4-6-25(22)37)33(52)48-34(43-32(44-48)21-9-15-53-16-10-21)47(27)20-29(50)42-26-8-7-23(18-24(26)36)35(38,39)40/h3-9,18H,2,10-17,19-20H2,1H3,(H,41,49)(H,42,50)	KMBSBKNAHLDDJO-UHFFFAOYSA-N	332561	N-(2-Chloro-4- (trifluoromethyl)phenyl)-2-(2-(3,6- dihydro-2H-pyran-4-yl)-5-ethyl-6- (4-((2-(2- fluorophenyl)acetyl)glycyl)piperazin- 1-yl)-7-oxo-[1,2,4]triazolo[1,5- a]pyrimidin-4(7H)-yl)acetamide::US20260015358, Example 274	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332561	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332561&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			138403804	384577275							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192562	CCc1c(N2CCN(C(=O)CNC(=O)CC3CC3)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C32H36ClF3N8O5/c1-2-24-28(42-11-9-41(10-12-42)27(47)17-37-25(45)15-19-3-4-19)30(48)44-31(39-29(40-44)20-7-13-49-14-8-20)43(24)18-26(46)38-23-6-5-21(16-22(23)33)32(34,35)36/h5-7,16,19H,2-4,8-15,17-18H2,1H3,(H,37,45)(H,38,46)	SUOKLTFZHZTSPD-UHFFFAOYSA-N	332562	N-(2-Chloro-4- (trifluoromethyl)phenyl)-2-(6-(4- ((2- cyclopropylacetyl)glycyl)piperazin- 1-yl)-2-(3,6-dihydro-2H-pyran-4- yl)-5-ethyl-7-oxo- [1,2,4]triazolo[1,5-a]pyrimidin- 4(7H)-yl)acetamide::US20260015358, Example 275	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332562	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332562&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			117979007	384577276							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192563	CCc1c(N2CCN(C(=O)CNC(=O)Cc3cscn3)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C32H33ClF3N9O5S/c1-2-24-28(43-9-7-42(8-10-43)27(48)15-37-25(46)14-21-17-51-18-38-21)30(49)45-31(40-29(41-45)19-5-11-50-12-6-19)44(24)16-26(47)39-23-4-3-20(13-22(23)33)32(34,35)36/h3-5,13,17-18H,2,6-12,14-16H2,1H3,(H,37,46)(H,39,47)	GTYIOOGQOPRJGI-UHFFFAOYSA-N	332563	N-(2-Chloro-4- (trifluoromethyl)phenyl)-2-(2-(3,6- dihydro-2H-pyran-4-yl)-5-ethyl-7- oxo-6-(4-((2-(thiazol-4- yl)acetyl)glycyl)piperazin-1-yl)- [1,2,4]triazolo[1,5-a]pyrimidin- 4(7H)-yl)acetamide::US20260015358, Example 276	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332563	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332563&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			117979018	384577277							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192564	CCc1c(N2CCN(C(=O)CNC(=O)c3cccc(NC)c3)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C35H37ClF3N9O5/c1-3-27-30(46-13-11-45(12-14-46)29(50)19-41-32(51)22-5-4-6-24(17-22)40-2)33(52)48-34(43-31(44-48)21-9-15-53-16-10-21)47(27)20-28(49)42-26-8-7-23(18-25(26)36)35(37,38)39/h4-9,17-18,40H,3,10-16,19-20H2,1-2H3,(H,41,51)(H,42,49)	MWAGKGVVZGMDGI-UHFFFAOYSA-N	332564	N-(2-(4-(4-(2-((2-Chloro-4- (trifluoromethyl)phenyl)amino)-2- oxoethyl)-2-(3,6-dihydro-2H- pyran-4-yl)-5-ethyl-7-oxo-4,7- dihydro-[1,2,4]triazolo[1,5- a]pyrimidin-6-yl)piperazin-1-yl)-2- oxoethyl)-3- (methylamino)benzamide::US20260015358, Example 277	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332564	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332564&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			117978882	384577278							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192565	CCc1c(N2CCN(C(=O)CNC(=O)c3cccc(NC(C)=O)c3)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C36H37ClF3N9O6/c1-3-28-31(47-13-11-46(12-14-47)30(52)19-41-33(53)23-5-4-6-25(17-23)42-21(2)50)34(54)49-35(44-32(45-49)22-9-15-55-16-10-22)48(28)20-29(51)43-27-8-7-24(18-26(27)37)36(38,39)40/h4-9,17-18H,3,10-16,19-20H2,1-2H3,(H,41,53)(H,42,50)(H,43,51)	WJUOZHORAOPIDZ-UHFFFAOYSA-N	332565	3-Acetamido-N-(2-(4-(4-(2-((2- chloro-4- (trifluoromethyl)phenyl)amino)-2- oxoethyl)-2-(3,6-dihydro-2H- pyran-4-yl)-5-ethyl-7-oxo-4,7- dihydro-[1,2,4]triazolo[1,5- a]pyrimidin-6-yl)piperazin-1-yl)-2- oxoethyl)benzamide::US20260015358, Example 278	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332565	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332565&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			117978873	384577279							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192566	CCc1c(N2CCN(C(=O)CNC(=O)c3ccnc(O)c3)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C33H33ClF3N9O6/c1-2-24-28(44-11-9-43(10-12-44)27(49)17-39-30(50)20-5-8-38-25(47)15-20)31(51)46-32(41-29(42-46)19-6-13-52-14-7-19)45(24)18-26(48)40-23-4-3-21(16-22(23)34)33(35,36)37/h3-6,8,15-16H,2,7,9-14,17-18H2,1H3,(H,38,47)(H,39,50)(H,40,48)	DOARKGSPUVKDON-UHFFFAOYSA-N	332566	N-(2-(4-(4-(2-((2-Chloro-4- (trifluoromethyl)phenyl)amino)-2- oxoethyl)-2-(3,6-dihydro-2H- pyran-4-yl)-5-ethyl-7-oxo-4,7- dihydro-[1,2,4]triazolo[1,5- a]pyrimidin-6-yl)piperazin-1-yl)-2- oxoethyl)-2- hydroxyisonicotinamide::US20260015358, Example 279	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332566	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332566&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			137446172	384577280							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192567	CCc1c(N2CCN(C(=O)CNC(=O)c3cnccc3O)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C33H33ClF3N9O6/c1-2-24-28(44-11-9-43(10-12-44)27(49)17-39-30(50)21-16-38-8-5-25(21)47)31(51)46-32(41-29(42-46)19-6-13-52-14-7-19)45(24)18-26(48)40-23-4-3-20(15-22(23)34)33(35,36)37/h3-6,8,15-16H,2,7,9-14,17-18H2,1H3,(H,38,47)(H,39,50)(H,40,48)	NFZANSQHWCWCQX-UHFFFAOYSA-N	332567	N-(2-(4-(4-(2-((2-Chloro-4- (trifluoromethyl)phenyl)amino)-2- oxoethyl)-2-(3,6-dihydro-2H- pyran-4-yl)-5-ethyl-7-oxo-4,7- dihydro-[1,2,4]triazolo[1,5- a]pyrimidin-6-yl)piperazin-1-yl)-2- oxoethyl)-4-hydroxynicotinamide::US20260015358, Example 280	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332567	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332567&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			137446177	384577281							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192568	CCc1c(N2CCN(C(=O)CNC(=O)c3cncc(O)c3)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C33H33ClF3N9O6/c1-2-25-28(44-9-7-43(8-10-44)27(49)17-39-30(50)20-13-22(47)16-38-15-20)31(51)46-32(41-29(42-46)19-5-11-52-12-6-19)45(25)18-26(48)40-24-4-3-21(14-23(24)34)33(35,36)37/h3-5,13-16,47H,2,6-12,17-18H2,1H3,(H,39,50)(H,40,48)	ROQPFBOKPJUBPU-UHFFFAOYSA-N	332568	N-(2-(4-(4-(2-((2-Chloro-4- (trifluoromethyl)phenyl)amino)-2- oxoethyl)-2-(3,6-dihydro-2H- pyran-4-yl)-5-ethyl-7-oxo-4,7- dihydro-[1,2,4]triazolo[1,5- a]pyrimidin-6-yl)piperazin-1-yl)-2- oxoethyl)-5-hydroxynicotinamide::US20260015358, Example 281	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332568	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332568&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			138403805	384577282							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192569	CCc1c(N2CCN(C(=O)CNC(=O)c3cccnc3O)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C33H33ClF3N9O6/c1-2-24-27(44-12-10-43(11-13-44)26(48)17-39-30(50)21-4-3-9-38-29(21)49)31(51)46-32(41-28(42-46)19-7-14-52-15-8-19)45(24)18-25(47)40-23-6-5-20(16-22(23)34)33(35,36)37/h3-7,9,16H,2,8,10-15,17-18H2,1H3,(H,38,49)(H,39,50)(H,40,47)	ZOMBWIZGXVSJLD-UHFFFAOYSA-N	332569	N-(2-(4-(4-(2-((2-Chloro-4- (trifluoromethyl)phenyl)amino)-2- oxoethyl)-2-(3,6-dihydro-2H- pyran-4-yl)-5-ethyl-7-oxo-4,7- dihydro-[1,2,4]triazolo[1,5- a]pyrimidin-6-yl)piperazin-1-yl)-2- oxoethyl)-2-hydroxynicotinamide::US20260015358, Example 282	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332569	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332569&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			121410133	384577283							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192570	CCc1c(N2CCN(C(=O)CNC(=O)c3cn(C)[nH]c3=O)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C32H34ClF3N10O6/c1-3-23-26(44-10-8-43(9-11-44)25(48)15-37-28(49)20-16-42(2)41-29(20)50)30(51)46-31(39-27(40-46)18-6-12-52-13-7-18)45(23)17-24(47)38-22-5-4-19(14-21(22)33)32(34,35)36/h4-6,14,16H,3,7-13,15,17H2,1-2H3,(H,37,49)(H,38,47)(H,41,50)	LQWUBXKLXHIMJT-UHFFFAOYSA-N	332570	N-(2-(4-(4-(2-((2-Chloro-4-(trifluoromethyl)phenyl)amino)-2-oxoethyl)-2-(3,6-dihydro-2H-pyran-4-yl)-5-ethyl-7-oxo-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)piperazin-1-yl)-2-oxoethyl)-1-methyl-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxamide::US20260015358, Example 283	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		 550							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332570	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332570&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			117978917	384577284							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192571	CCc1c(N2CCN(C(=O)CNC(=O)c3cc(F)cc(NC)c3)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C35H36ClF4N9O5/c1-3-27-30(47-10-8-46(9-11-47)29(51)18-42-32(52)21-14-23(37)17-24(15-21)41-2)33(53)49-34(44-31(45-49)20-6-12-54-13-7-20)48(27)19-28(50)43-26-5-4-22(16-25(26)36)35(38,39)40/h4-6,14-17,41H,3,7-13,18-19H2,1-2H3,(H,42,52)(H,43,50)	FRIBTJFDXGNYAW-UHFFFAOYSA-N	332571	US20260015358, Example 284	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332571	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332571&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			117978897	384577285							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192572	CCc1c(N2CCN(C(=O)CNC(=O)c3ccc(F)c(NC)c3)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C35H36ClF4N9O5/c1-3-27-30(47-12-10-46(11-13-47)29(51)18-42-32(52)21-4-6-24(37)26(16-21)41-2)33(53)49-34(44-31(45-49)20-8-14-54-15-9-20)48(27)19-28(50)43-25-7-5-22(17-23(25)36)35(38,39)40/h4-8,16-17,41H,3,9-15,18-19H2,1-2H3,(H,42,52)(H,43,50)	HFXXZCZBGNLWMX-UHFFFAOYSA-N	332572	US20260015358, Example 285	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332572	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332572&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			117978832	384577286							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192573	CCc1c(N2CCN(C(=O)CNC(=O)c3ccc(F)c(N(C)C)c3)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C36H38ClF4N9O5/c1-4-27-31(48-13-11-47(12-14-48)30(52)19-42-33(53)22-5-7-25(38)28(17-22)46(2)3)34(54)50-35(44-32(45-50)21-9-15-55-16-10-21)49(27)20-29(51)43-26-8-6-23(18-24(26)37)36(39,40)41/h5-9,17-18H,4,10-16,19-20H2,1-3H3,(H,42,53)(H,43,51)	CLTIDSJTEOWQCS-UHFFFAOYSA-N	332573	US20260015358, Example 286	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332573	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332573&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			117978912	384577287							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192574	CCc1c(N2CCN(C(=O)CNC(=O)c3cccc(NC)c3F)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C35H36ClF4N9O5/c1-3-26-30(47-13-11-46(12-14-47)28(51)18-42-32(52)22-5-4-6-25(41-2)29(22)37)33(53)49-34(44-31(45-49)20-9-15-54-16-10-20)48(26)19-27(50)43-24-8-7-21(17-23(24)36)35(38,39)40/h4-9,17,41H,3,10-16,18-19H2,1-2H3,(H,42,52)(H,43,50)	JIADBCWPSAMWAP-UHFFFAOYSA-N	332574	US20260015358, Example 287	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332574	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332574&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			117979252	384577288							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192575	CCc1c(N2CCN(C(=O)CNC(=O)c3cccc(N)c3)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C34H35ClF3N9O5/c1-2-26-29(45-12-10-44(11-13-45)28(49)18-40-31(50)21-4-3-5-23(39)16-21)32(51)47-33(42-30(43-47)20-8-14-52-15-9-20)46(26)19-27(48)41-25-7-6-22(17-24(25)35)34(36,37)38/h3-8,16-17H,2,9-15,18-19,39H2,1H3,(H,40,50)(H,41,48)	GXFMCWAVTLOLBG-UHFFFAOYSA-N	332575	3-Amino-N-(2-(4-(4-(2-((2-chloro-4-(trifluoromethyl)phenyl)amino)-2-oxoethyl)-2-(3,6-dihydro-2H-pyran-4-yl)-5-ethyl-7-oxo-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)piperazin-1-yl)-2-oxoethyl)benzamide::US20260015358, Example 288	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332575	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332575&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			117978857	384577289							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192576	CCc1c(N2CCN(C(=O)CNC(=O)c3cc(NC)ccc3F)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C35H36ClF4N9O5/c1-3-27-30(47-12-10-46(11-13-47)29(51)18-42-32(52)23-17-22(41-2)5-6-25(23)37)33(53)49-34(44-31(45-49)20-8-14-54-15-9-20)48(27)19-28(50)43-26-7-4-21(16-24(26)36)35(38,39)40/h4-8,16-17,41H,3,9-15,18-19H2,1-2H3,(H,42,52)(H,43,50)	JFBNIUORRQSEGU-UHFFFAOYSA-N	332576	US20260015358, Example 289	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332576	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332576&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			138403806	384577290							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192577	CCc1c(N2CCN(C(=O)CNC(=O)c3cc(O)ccc3F)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C34H33ClF4N8O6/c1-2-26-29(45-11-9-44(10-12-45)28(50)17-40-31(51)22-16-21(48)4-5-24(22)36)32(52)47-33(42-30(43-47)19-7-13-53-14-8-19)46(26)18-27(49)41-25-6-3-20(15-23(25)35)34(37,38)39/h3-7,15-16,48H,2,8-14,17-18H2,1H3,(H,40,51)(H,41,49)	CUFAQYWSPPIAEL-UHFFFAOYSA-N	332577	US20260015358, Example 290	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332577	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332577&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			117978911	384577291							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192578	CCc1c(N2CCN(C(=O)CNC(=O)c3cc(O)cc(F)c3)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C34H33ClF4N8O6/c1-2-26-29(45-9-7-44(8-10-45)28(50)17-40-31(51)20-13-22(36)16-23(48)14-20)32(52)47-33(42-30(43-47)19-5-11-53-12-6-19)46(26)18-27(49)41-25-4-3-21(15-24(25)35)34(37,38)39/h3-5,13-16,48H,2,6-12,17-18H2,1H3,(H,40,51)(H,41,49)	UIFLIUPMKLEADQ-UHFFFAOYSA-N	332578	US20260015358, Example 291	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332578	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332578&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			117978993	384577292							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192579	CCc1c(N2CCN(C(=O)CNC(=O)c3ccc(F)c(O)c3)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C34H33ClF4N8O6/c1-2-25-29(45-11-9-44(10-12-45)28(50)17-40-31(51)20-3-5-23(36)26(48)15-20)32(52)47-33(42-30(43-47)19-7-13-53-14-8-19)46(25)18-27(49)41-24-6-4-21(16-22(24)35)34(37,38)39/h3-7,15-16,48H,2,8-14,17-18H2,1H3,(H,40,51)(H,41,49)	UBSMDLCZMMNRAP-UHFFFAOYSA-N	332579	US20260015358, Example 292	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332579	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332579&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			117978997	384577293							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192580	CCc1c(N2CCN(C(=O)CNC(=O)c3cccc(O)c3F)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C34H33ClF4N8O6/c1-2-24-29(45-12-10-44(11-13-45)27(50)17-40-31(51)21-4-3-5-25(48)28(21)36)32(52)47-33(42-30(43-47)19-8-14-53-15-9-19)46(24)18-26(49)41-23-7-6-20(16-22(23)35)34(37,38)39/h3-8,16,48H,2,9-15,17-18H2,1H3,(H,40,51)(H,41,49)	DCMCQPNLRUNIKW-UHFFFAOYSA-N	332580	US20260015358, Example 293	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332580	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332580&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			117978905	384577294							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192581	CCc1c(N2CCN(C(=O)CNC(=O)c3c(O)cc(C)oc3=O)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C34H34ClF3N8O8/c1-3-23-28(44-10-8-43(9-11-44)26(49)16-39-30(50)27-24(47)14-18(2)54-32(27)52)31(51)46-33(41-29(42-46)19-6-12-53-13-7-19)45(23)17-25(48)40-22-5-4-20(15-21(22)35)34(36,37)38/h4-6,14-15,47H,3,7-13,16-17H2,1-2H3,(H,39,50)(H,40,48)	BCPGUKUOIDGXFR-UHFFFAOYSA-N	332581	N-(2-(4-(4-(2-((2-Chloro-4-(trifluoromethyl)phenyl)amino)-2-oxoethyl)-2-(3,6-dihydro-2H-pyran-4-yl)-5-ethyl-7-oxo-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)piperazin-1-yl)-2-oxoethyl)-4-hydroxy-6-methyl-2-oxo-2H-pyran-3-carboxamide::US20260015358, Example 295	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		 550							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332581	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332581&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			138403807	384577295							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192582	CCc1c(N2CCN(C(=O)c3cc4ccnn4cn3)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C32H30ClF3N10O4/c1-2-25-27(42-9-11-43(12-10-42)29(48)24-16-21-5-8-38-45(21)18-37-24)30(49)46-31(40-28(41-46)19-6-13-50-14-7-19)44(25)17-26(47)39-23-4-3-20(15-22(23)33)32(34,35)36/h3-6,8,15-16,18H,2,7,9-14,17H2,1H3,(H,39,47)	IOHHPGYRHXVKRO-UHFFFAOYSA-N	332582	US20260015358, Example 296	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		 550							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332582	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332582&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			138403808	384577296							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192583	CCc1c(N2CCN(C(=O)c3cnc4sc(Br)cc4c3O)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1F	InChI=1S/C33H29BrF4N8O5S/c1-2-23-26(43-7-9-44(10-8-43)30(49)20-15-39-29-19(27(20)48)14-24(34)52-29)31(50)46-32(41-28(42-46)17-5-11-51-12-6-17)45(23)16-25(47)40-22-4-3-18(13-21(22)35)33(36,37)38/h3-5,13-15H,2,6-12,16H2,1H3,(H,39,48)(H,40,47)	KQNWZEVJLIIUHY-UHFFFAOYSA-N	332583	2-(6-(4-(2-Bromo-4-hydroxythieno[2,3-b]pyridine-5-carbonyl)piperazin-1-yl)-2-(3,6-dihydro-2H-pyran-4-yl)-5-ethyl-7-oxo-[1,2,4]triazolo[1,5-a]pyrimidin-4(7H)-yl)-N-(2-fluoro-4-(trifluoromethyl)phenyl)acetamide::US20260015358, Example 297	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332583	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332583&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			121410141	384577297							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192584	CCc1c(N2CCN(C(=O)c3cnn4cccc4c3O)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1sc(C)cc1C	InChI=1S/C32H35N9O5S/c1-4-23-26(37-10-12-38(13-11-37)30(44)22-17-33-40-9-5-6-24(40)27(22)43)31(45)41-32(35-28(36-41)21-7-14-46-15-8-21)39(23)18-25(42)34-29-19(2)16-20(3)47-29/h5-7,9,16-17,43H,4,8,10-15,18H2,1-3H3,(H,34,42)	CZSASCLZMPCWEZ-UHFFFAOYSA-N	332584	2-(2-(3,6-Dihydro-2H-pyran-4-yl)-5-ethyl-6-(4-(4-hydroxypyrrolo[1,2-b]pyridazine-3-carbonyl)piperazin-1-yl)-7-oxo-[1,2,4]triazolo[1,5-a]pyrimidin-4(7H)-yl)-N-(3,5-dimethylthiophen-2-yl)acetamide::US20260015358, Example 298	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332584	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332584&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			138403809	384577298							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192585	CCc1c(N2CCN(C(=O)c3[nH]cnc3F)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C29H28ClF4N9O4/c1-2-20-23(40-7-9-41(10-8-40)26(45)22-24(31)36-15-35-22)27(46)43-28(38-25(39-43)16-5-11-47-12-6-16)42(20)14-21(44)37-19-4-3-17(13-18(19)30)29(32,33)34/h3-5,13,15H,2,6-12,14H2,1H3,(H,35,36)(H,37,44)	HPCNUUQYAWNWAW-UHFFFAOYSA-N	332585	US20260015358, Example 299	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		 550							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332585	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332585&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			117978824	384577299							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192586	CCc1c(N2CCN(C(=O)c3[nH]c4ccncc4c3F)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C33H30ClF4N9O4/c1-2-24-28(44-9-11-45(12-10-44)30(49)27-26(35)20-16-39-8-5-22(20)41-27)31(50)47-32(42-29(43-47)18-6-13-51-14-7-18)46(24)17-25(48)40-23-4-3-19(15-21(23)34)33(36,37)38/h3-6,8,15-16,41H,2,7,9-14,17H2,1H3,(H,40,48)	UUIQBNSKUFSGNJ-UHFFFAOYSA-N	332587	US20260015358, Example 300	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		 550							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332587	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332587&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			138403810	384577300							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192587	CCc1c(N2CCN(C(=O)CNC(=O)c3nc(C)co3)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C32H33ClF3N9O6/c1-3-23-26(43-10-8-42(9-11-43)25(47)15-37-28(48)29-38-18(2)17-51-29)30(49)45-31(40-27(41-45)19-6-12-50-13-7-19)44(23)16-24(46)39-22-5-4-20(14-21(22)33)32(34,35)36/h4-6,14,17H,3,7-13,15-16H2,1-2H3,(H,37,48)(H,39,46)	FBEOHMCUSLDJKK-UHFFFAOYSA-N	332588	US20260015358, Example 301	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		 550							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332588	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332588&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			137446173	384577301							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192588	CCc1c(N2CCN(C(=O)c3cnn4ccc(C)c4c3O)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C34H33ClF3N9O5/c1-3-25-28(43-10-12-44(13-11-43)31(50)22-17-39-46-9-6-19(2)27(46)29(22)49)32(51)47-33(41-30(42-47)20-7-14-52-15-8-20)45(25)18-26(48)40-24-5-4-21(16-23(24)35)34(36,37)38/h4-7,9,16-17,49H,3,8,10-15,18H2,1-2H3,(H,40,48)	LCDSZDRCTFODGU-UHFFFAOYSA-N	332589	US20260015358, Example 303	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332589	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332589&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			117978855	384577302							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192589	CCc1c(N2CCN(C(=O)c3c(O)nn4ccccc34)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C33H31ClF3N9O5/c1-2-23-27(42-11-13-43(14-12-42)30(49)26-24-5-3-4-10-45(24)41-29(26)48)31(50)46-32(39-28(40-46)19-8-15-51-16-9-19)44(23)18-25(47)38-22-7-6-20(17-21(22)34)33(35,36)37/h3-8,10,17H,2,9,11-16,18H2,1H3,(H,38,47)(H,41,48)	PPNOKQJWERRIIX-UHFFFAOYSA-N	332590	US20260015358, Example 304	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332590	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332590&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			137446171	384577303							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192590	CCc1c(N2CCN(C(=O)c3nc4ccsc4cc3O)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C33H30ClF3N8O5S/c1-2-23-28(42-8-10-43(11-9-42)30(48)27-24(46)16-25-22(39-27)7-14-51-25)31(49)45-32(40-29(41-45)18-5-12-50-13-6-18)44(23)17-26(47)38-21-4-3-19(15-20(21)34)33(35,36)37/h3-5,7,14-16,46H,2,6,8-13,17H2,1H3,(H,38,47)	PROMVBOKECMMOG-UHFFFAOYSA-N	332591	US20260015358, Example 305	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332591	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332591&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			138403811	384577304							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192591	CCc1c(N2CCN(C(=O)c3nc4ccccc4cc3O)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C35H32ClF3N8O5/c1-2-26-30(44-11-13-45(14-12-44)32(50)29-27(48)17-21-5-3-4-6-24(21)41-29)33(51)47-34(42-31(43-47)20-9-15-52-16-10-20)46(26)19-28(49)40-25-8-7-22(18-23(25)36)35(37,38)39/h3-9,17-18,48H,2,10-16,19H2,1H3,(H,40,49)	QQNSPCDQQYXIED-UHFFFAOYSA-N	332592	US20260015358, Example 306	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332592	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332592&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			121410136	384577305							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192592	CCc1c(N2CCN(C(=O)c3nc4ccccc4cc3N)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C35H33ClF3N9O4/c1-2-27-30(45-11-13-46(14-12-45)32(50)29-24(40)17-21-5-3-4-6-25(21)42-29)33(51)48-34(43-31(44-48)20-9-15-52-16-10-20)47(27)19-28(49)41-26-8-7-22(18-23(26)36)35(37,38)39/h3-9,17-18H,2,10-16,19,40H2,1H3,(H,41,49)	DXASGJSEMWWQRF-UHFFFAOYSA-N	332593	2-(6-(4-(3-Aminoquinoline-2-carbonyl)piperazin-1-yl)-2-(3,6-dihydro-2H-pyran-4-yl)-5-ethyl-7-oxo-[1,2,4]triazolo[1,5-a]pyrimidin-4(7H)-yl)-N-(2-chloro-4(trifluoromethyl)phenyl)acetamide::US20260015358, Example 307	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		 550							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332593	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332593&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			138403812	384577306							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192593	CCc1c(N2CCN(C(=O)c3cnc4sc(Cl)nc4c3O)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1F	InChI=1S/C32H28ClF4N9O5S/c1-2-21-24(43-7-9-44(10-8-43)28(49)18-14-38-27-23(25(18)48)40-30(33)52-27)29(50)46-31(41-26(42-46)16-5-11-51-12-6-16)45(21)15-22(47)39-20-4-3-17(13-19(20)34)32(35,36)37/h3-5,13-14H,2,6-12,15H2,1H3,(H,38,48)(H,39,47)	ATQAGZNWYZUPNU-UHFFFAOYSA-N	332594	2-(6-(4-(2-Chloro-7-hydroxythiazolo[5,4-b]pyridine-6-carbonyl)piperazin-1-yl)-2-(3,6-dihydro-2H-pyran-4-yl)-5-ethyl-7-oxo-[1,2,4]triazolo[1,5-a]pyrimidin-4(7H)-yl)-N-(2-fluoro-4-(trifluoromethyl)phenyl)acetamide::US20260015358, Example 308	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332594	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332594&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			117979077	384577307							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192594	CCc1c(N2CCN(C(=O)c3nnc(C(F)F)[nH]3)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1F	InChI=1S/C29H28F6N10O4/c1-2-19-21(42-7-9-43(10-8-42)27(48)25-37-24(22(31)32)39-40-25)26(47)45-28(38-23(41-45)15-5-11-49-12-6-15)44(19)14-20(46)36-18-4-3-16(13-17(18)30)29(33,34)35/h3-5,13,22H,2,6-12,14H2,1H3,(H,36,46)(H,37,39,40)	CJRQYMZPJSEDKK-UHFFFAOYSA-N	332595	2-(6-(4-(5-(Difluoromethyl)-4H-1,2,4-triazole-3-carbonyl)piperazin-1-yl)-2-(3,6-dihydro-2H-pyran-4-yl)-5-ethyl-7-oxo-[1,2,4]triazolo[1,5-a]pyrimidin-4(7H)-yl)-N-(2-fluoro-4-(trifluoromethyl)phenyl)acetamide::US20260015358, Example 310	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332595	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332595&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			117978838	384577308							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192595	CCc1c(N2CCN(C(=O)c3nnc(C(F)(F)F)[nH]3)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1F	InChI=1S/C29H27F7N10O4/c1-2-19-21(43-7-9-44(10-8-43)25(49)23-38-26(41-40-23)29(34,35)36)24(48)46-27(39-22(42-46)15-5-11-50-12-6-15)45(19)14-20(47)37-18-4-3-16(13-17(18)30)28(31,32)33/h3-5,13H,2,6-12,14H2,1H3,(H,37,47)(H,38,40,41)	YHUSDONXHHEFHL-UHFFFAOYSA-N	332596	2-(2-(3,6-Dihydro-2H-pyran-4-yl)-5-ethyl-7-oxo-6-(4-(5-(trifluoromethyl)-4H-1,2,4-triazole-3-carbonyl)piperazin-1-yl)-[1,2,4]triazolo[1,5-a]pyrimidin-4(7H)-yl)-N-(2-fluoro-4-(trifluoromethyl)phenyl)acetamide::US20260015358, Example 311	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332596	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332596&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			117978801	384577309							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192596	CCc1c(N2CCN(C(=O)c3nnc(C)[nH]3)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1F	InChI=1S/C29H30F4N10O4/c1-3-21-23(40-8-10-41(11-9-40)27(46)25-34-16(2)37-38-25)26(45)43-28(36-24(39-43)17-6-12-47-13-7-17)42(21)15-22(44)35-20-5-4-18(14-19(20)30)29(31,32)33/h4-6,14H,3,7-13,15H2,1-2H3,(H,35,44)(H,34,37,38)	FCUDBYUMZFSPRS-UHFFFAOYSA-N	332597	2-(2-(3,6-Dihydro-2H-pyran-4-yl)-5-ethyl-6-(4-(5-methyl-4H-1,2,4-triazole-3-carbonyl)piperazin-1-yl)-7-oxo-[1,2,4]triazolo[1,5-a]pyrimidin-4(7H)-yl)-N-(2-fluoro-4-(trifluoromethyl)phenyl)acetamide::US20260015358, Example 312	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		 550							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332597	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332597&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			117978884	384577310							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192597	CCc1c(N2CCN(C(=O)c3cc4cnccc4[nH]3)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C33H31ClF3N9O4/c1-2-26-28(43-9-11-44(12-10-43)30(48)25-15-20-17-38-8-5-23(20)39-25)31(49)46-32(41-29(42-46)19-6-13-50-14-7-19)45(26)18-27(47)40-24-4-3-21(16-22(24)34)33(35,36)37/h3-6,8,15-17,39H,2,7,9-14,18H2,1H3,(H,40,47)	UHYHAJAFQMCGKY-UHFFFAOYSA-N	332598	2-(6-(4-(1H-Pyrrolo[3,2-c]pyridine-2-carbonyl)piperazin-1-yl)-2-(3,6-dihydro-2H-pyran-4-yl)-5-ethyl-7-oxo-[1,2,4]triazolo[1,5-a]pyrimidin-4(7H)-yl)-N-(2-chloro-4-(trifluoromethyl)phenyl)acetamide::US20260015358, Example 313	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		 550							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332598	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332598&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			117979071	384577311							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192598	CCc1c(N2CCN(C(=O)c3c(OC)cn[nH]c3=O)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C31H31ClF3N9O6/c1-3-21-25(41-8-10-42(11-9-41)28(47)24-22(49-2)15-36-39-27(24)46)29(48)44-30(38-26(40-44)17-6-12-50-13-7-17)43(21)16-23(45)37-20-5-4-18(14-19(20)32)31(33,34)35/h4-6,14-15H,3,7-13,16H2,1-2H3,(H,37,45)(H,39,46)	DLHWOPCKOILWHX-UHFFFAOYSA-N	332599	US20260015358, Example 314	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		 550							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332599	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332599&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			117979011	384577312							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192599	CCc1c(N2CCN(C(=O)c3cnn4cccc4c3O)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1F	InChI=1S/C33H31F4N9O5/c1-2-24-27(42-10-12-43(13-11-42)30(49)21-17-38-45-9-3-4-25(45)28(21)48)31(50)46-32(40-29(41-46)19-7-14-51-15-8-19)44(24)18-26(47)39-23-6-5-20(16-22(23)34)33(35,36)37/h3-7,9,16-17,48H,2,8,10-15,18H2,1H3,(H,39,47)	UDXZWUMAGPSAJG-UHFFFAOYSA-N	332600	2-(2-(3,6-Dihydro-2H-pyran-4-yl)-5-ethyl-6-(4-(4-hydroxypyrrolo[1,2-b]pyridazine-3-carbonyl)piperazin-1-yl)-7-oxo-[1,2,4]triazolo[1,5-a]pyrimidin-4(7H)-yl)-N-(2-fluoro-4-(trifluoromethyl)phenyl)acetamide::US20260015358, Example 318	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332600	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332600&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			138403813	384577313							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192600	CCc1c(N2CCN(C(=O)CNC(=O)c3c(F)cccc3Cl)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C34H32Cl2F4N8O5/c1-2-25-29(46-12-10-45(11-13-46)27(50)17-41-31(51)28-21(35)4-3-5-23(28)37)32(52)48-33(43-30(44-48)19-8-14-53-15-9-19)47(25)18-26(49)42-24-7-6-20(16-22(24)36)34(38,39)40/h3-8,16H,2,9-15,17-18H2,1H3,(H,41,51)(H,42,49)	JAGNFLZYPWSMLN-UHFFFAOYSA-N	332601	2-Chloro-N-(2-(4-(4-(2-((2-chloro-4-(trifluoromethyl)phenyl)amino)-2-oxoethyl)-2-(3,6-dihydro-2H-pyran-4-yl)-5-ethyl-7-oxo-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)piperazin-1-yl)-2-oxoethyl)-6-fluorobenzamide::US20260015358, Example 319	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332601	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332601&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			121410135	384577314							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192601	CCc1c(N2CCN(C(=O)CNC(=O)CC(C)C)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C32H38ClF3N8O5/c1-4-24-28(42-11-9-41(10-12-42)27(47)17-37-25(45)15-19(2)3)30(48)44-31(39-29(40-44)20-7-13-49-14-8-20)43(24)18-26(46)38-23-6-5-21(16-22(23)33)32(34,35)36/h5-7,16,19H,4,8-15,17-18H2,1-3H3,(H,37,45)(H,38,46)	PKAYIBRRWLKGMD-UHFFFAOYSA-N	332602	US20260015358, Example 320	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332602	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332602&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			121410138	384577315							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192602	CCc1c(N2CCN(C(=O)CNC(=O)[C@H]3CCCO3)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C32H36ClF3N8O6/c1-2-23-27(42-11-9-41(10-12-42)26(46)17-37-29(47)24-4-3-13-50-24)30(48)44-31(39-28(40-44)19-7-14-49-15-8-19)43(23)18-25(45)38-22-6-5-20(16-21(22)33)32(34,35)36/h5-7,16,24H,2-4,8-15,17-18H2,1H3,(H,37,47)(H,38,45)	NQTLQRBSCNNVOS-UHFFFAOYSA-N	332603	US20260015358, Example 321	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		 550							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332603	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332603&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			138403814	384577316							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192603	CCc1c(N2CCN(C(=O)CNC(=O)[C@@H]3CCCO3)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C32H36ClF3N8O6/c1-2-23-27(42-11-9-41(10-12-42)26(46)17-37-29(47)24-4-3-13-50-24)30(48)44-31(39-28(40-44)19-7-14-49-15-8-19)43(23)18-25(45)38-22-6-5-20(16-21(22)33)32(34,35)36/h5-7,16,24H,2-4,8-15,17-18H2,1H3,(H,37,47)(H,38,45)	NQTLQRBSCNNVOS-UHFFFAOYSA-N	332604	US20260015358, Example 322	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332604	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332604&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			121410137	384577317							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192604	CCc1c(N2CCN(C(=O)CN(C)C(C)=O)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C30H34ClF3N8O5/c1-4-23-26(40-11-9-39(10-12-40)25(45)17-38(3)18(2)43)28(46)42-29(36-27(37-42)19-7-13-47-14-8-19)41(23)16-24(44)35-22-6-5-20(15-21(22)31)30(32,33)34/h5-7,15H,4,8-14,16-17H2,1-3H3,(H,35,44)	UOKCVIYHSSRCRP-UHFFFAOYSA-N	332605	2-(6-(4-(N-Acetyl-N-methylglycyl)piperazin-1-yl)-2-(3,6-dihydro-2H-pyran-4-yl)-5-ethyl-7-oxo-[1,2,4]triazolo[1,5-a]pyrimidin-4(7H)-yl)-N-(2-chloro-4-(trifluoromethyl)phenyl)acetamide::US20260015358, Example 323	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		 550							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332605	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332605&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			138403815	384577318							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192605	CCc1c(N2CCN(C(=O)C(=O)Nc3cc(C)no3)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1F	InChI=1S/C31H31F4N9O6/c1-3-22-25(41-8-10-42(11-9-41)29(48)27(46)37-24-14-17(2)40-50-24)28(47)44-30(38-26(39-44)18-6-12-49-13-7-18)43(22)16-23(45)36-21-5-4-19(15-20(21)32)31(33,34)35/h4-6,14-15H,3,7-13,16H2,1-2H3,(H,36,45)(H,37,46)	IWRDLSDWDBASRC-UHFFFAOYSA-N	332606	2-(4-(2-(3,6-Dihydro-2H-pyran-4-yl)-5-ethyl-4-(2-((2-fluoro-4-(trifluoromethyl)phenyl)amino)-2-oxoethyl)-7-oxo-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)piperazin-1-yl)-N-(3-methylisoxazol-5-yl)-2-oxoacetamide::US20260015358, Example 324	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332606	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332606&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			138403816	384577319							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192606	CCc1c(N2CCN(C(=O)C(=O)Nc3cc(C)ns3)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1F	InChI=1S/C31H31F4N9O5S/c1-3-22-25(41-8-10-42(11-9-41)29(48)27(46)37-24-14-17(2)40-50-24)28(47)44-30(38-26(39-44)18-6-12-49-13-7-18)43(22)16-23(45)36-21-5-4-19(15-20(21)32)31(33,34)35/h4-6,14-15H,3,7-13,16H2,1-2H3,(H,36,45)(H,37,46)	ZLMDOVPWNFUYLS-UHFFFAOYSA-N	332607	2-(4-(2-(3,6-Dihydro-2H-pyran-4-yl)-5-ethyl-4-(2-((2-fluoro-4-(trifluoromethyl)phenyl)amino)-2-oxoethyl)-7-oxo-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)piperazin-1-yl)-N-(3-methylisothiazol-5-yl)-2-oxoacetamide::US20260015358, Example 325	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332607	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332607&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			121410139	384577320							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192607	CCc1c(N2CCN(C(=O)C(=O)N(C)C)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C29H32ClF3N8O5/c1-4-21-23(38-9-11-39(12-10-38)27(45)26(44)37(2)3)25(43)41-28(35-24(36-41)17-7-13-46-14-8-17)40(21)16-22(42)34-20-6-5-18(15-19(20)30)29(31,32)33/h5-7,15H,4,8-14,16H2,1-3H3,(H,34,42)	MAEIZPJRVIHFTE-UHFFFAOYSA-N	332608	2-(4-(4-(2-((2-Chloro-4-(trifluoromethyl)phenyl)amino)-2-oxoethyl)-2-(3,6-dihydro-2H-pyran-4-yl)-5-ethyl-7-oxo-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)piperazin-1-yl)-N,N-dimethyl-2-oxoacetamide::US20260015358, Example 326	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		 550							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332608	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332608&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			138403817	384577321							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192608	CCc1c(N2CCN(C(=O)C(=O)Nc3ccccc3)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C33H32ClF3N8O5/c1-2-25-27(42-12-14-43(15-13-42)31(49)29(47)38-22-6-4-3-5-7-22)30(48)45-32(40-28(41-45)20-10-16-50-17-11-20)44(25)19-26(46)39-24-9-8-21(18-23(24)34)33(35,36)37/h3-10,18H,2,11-17,19H2,1H3,(H,38,47)(H,39,46)	JJDDYXXLOZHMIE-UHFFFAOYSA-N	332609	2-(4-(4-(2-((2-Chloro-4-(trifluoromethyl)phenyl)amino)-2-oxoethyl)-2-(3,6-dihydro-2H-pyran-4-yl)-5-ethyl-7-oxo-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)piperazin-1-yl)-2-oxo-N-phenylacetamide::US20260015358, Example 327	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		 550							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332609	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332609&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			117978909	384577322							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192609	CCc1c(N2CCN(C(=O)C(=O)NC)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C28H30ClF3N8O5/c1-3-20-22(37-8-10-38(11-9-37)26(44)24(42)33-2)25(43)40-27(35-23(36-40)16-6-12-45-13-7-16)39(20)15-21(41)34-19-5-4-17(14-18(19)29)28(30,31)32/h4-6,14H,3,7-13,15H2,1-2H3,(H,33,42)(H,34,41)	TXZJDRYLCCGGCC-UHFFFAOYSA-N	332610	2-(4-(4-(2-((2-Chloro-4-(trifluoromethyl)phenyl)amino)-2-oxoethyl)-2-(3,6-dihydro-2H-pyran-4-yl)-5-ethyl-7-oxo-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)piperazin-1-yl)-N-methyl-2-oxoacetamide::US20260015358, Example 329	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		 550							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332610	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332610&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			117979149	384577323							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192610	CCc1c(N2CCN(C(=O)C(=O)NOC)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C28H30ClF3N8O6/c1-3-20-22(37-8-10-38(11-9-37)26(44)24(42)36-45-2)25(43)40-27(34-23(35-40)16-6-12-46-13-7-16)39(20)15-21(41)33-19-5-4-17(14-18(19)29)28(30,31)32/h4-6,14H,3,7-13,15H2,1-2H3,(H,33,41)(H,36,42)	ADSYFXZDGCAHSN-UHFFFAOYSA-N	332611	2-(4-(4-(2-((2-Chloro-4-(trifluoromethyl)phenyl)amino)-2-oxoethyl)-2-(3,6-dihydro-2H-pyran-4-yl)-5-ethyl-7-oxo-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)piperazin-1-yl)-N-methoxy-2-oxoacetamide::US20260015358, Example 330	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332611	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332611&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			138403818	384577324							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192611	CCc1c(N2CCN(C(=O)C(=O)Nc3cc(C)[nH]n3)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C31H32ClF3N10O5/c1-3-22-25(42-8-10-43(11-9-42)29(49)27(47)37-23-14-17(2)39-40-23)28(48)45-30(38-26(41-45)18-6-12-50-13-7-18)44(22)16-24(46)36-21-5-4-19(15-20(21)32)31(33,34)35/h4-6,14-15H,3,7-13,16H2,1-2H3,(H,36,46)(H2,37,39,40,47)	SQRKNXFDSVWEJE-UHFFFAOYSA-N	332612	2-(4-(4-(2-((2-Chloro-4-(trifluoromethyl)phenyl)amino)-2-oxoethyl)-2-(3,6-dihydro-2H-pyran-4-yl)-5-ethyl-7-oxo-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)piperazin-1-yl)-N-(5-methyl-1H-pyrazol-3-yl)-2-oxoacetamide::US20260015358, Example 331	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332612	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332612&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			117978899	384577325							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192612	CCc1c(N2CCN(C(=O)C(=O)Nc3nccs3)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C30H29ClF3N9O5S/c1-2-21-23(40-8-10-41(11-9-40)27(47)25(45)38-28-35-7-14-49-28)26(46)43-29(37-24(39-43)17-5-12-48-13-6-17)42(21)16-22(44)36-20-4-3-18(15-19(20)31)30(32,33)34/h3-5,7,14-15H,2,6,8-13,16H2,1H3,(H,36,44)(H,35,38,45)	LFAFPUDUDUATQT-UHFFFAOYSA-N	332613	2-(4-(4-(2-((2-Chloro-4-(trifluoromethyl)phenyl)amino)-2-oxoethyl)-2-(3,6-dihydro-2H-pyran-4-yl)-5-ethyl-7-oxo-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)piperazin-1-yl)-2-oxo-N-(thiazol-2-yl)acetamide::US20260015358, Example 332	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332613	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332613&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			117979074	384577326							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192613	CCc1c(N2CCN(C(=O)C(=O)Nc3ccn[nH]3)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C30H30ClF3N10O5/c1-2-21-24(41-9-11-42(12-10-41)28(48)26(46)37-22-5-8-35-39-22)27(47)44-29(38-25(40-44)17-6-13-49-14-7-17)43(21)16-23(45)36-20-4-3-18(15-19(20)31)30(32,33)34/h3-6,8,15H,2,7,9-14,16H2,1H3,(H,36,45)(H2,35,37,39,46)	CARUHGACSFRULR-UHFFFAOYSA-N	332614	2-(4-(4-(2-((2-Chloro-4-(trifluoromethyl)phenyl)amino)-2-oxoethyl)-2-(3,6-dihydro-2H-pyran-4-yl)-5-ethyl-7-oxo-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)piperazin-1-yl)-2-oxo-N-(1H-pyrazol-5-yl)acetamide::US20260015358, Example 333	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332614	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332614&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			117979061	384577327							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192614	CCc1c(N2CCN(C(=O)C(=O)Nc3cncs3)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C30H29ClF3N9O5S/c1-2-21-24(40-7-9-41(10-8-40)28(47)26(45)37-23-14-35-16-49-23)27(46)43-29(38-25(39-43)17-5-11-48-12-6-17)42(21)15-22(44)36-20-4-3-18(13-19(20)31)30(32,33)34/h3-5,13-14,16H,2,6-12,15H2,1H3,(H,36,44)(H,37,45)	RVDKWIFWJRTMQR-UHFFFAOYSA-N	332615	2-(4-(4-(2-((2-Chloro-4-(trifluoromethyl)phenyl)amino)-2-oxoethyl)-2-(3,6-dihydro-2H-pyran-4-yl)-5-ethyl-7-oxo-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)piperazin-1-yl)-2-oxo-N-(thiazol-5-yl)acetamide::US20260015358, Example 334	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332615	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332615&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			117978989	384577328							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192615	CCc1c(N2CCN(C(=O)C(=O)Nc3cscn3)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C30H29ClF3N9O5S/c1-2-21-24(40-7-9-41(10-8-40)28(47)26(45)37-22-15-49-16-35-22)27(46)43-29(38-25(39-43)17-5-11-48-12-6-17)42(21)14-23(44)36-20-4-3-18(13-19(20)31)30(32,33)34/h3-5,13,15-16H,2,6-12,14H2,1H3,(H,36,44)(H,37,45)	CTUAHPYEXVLLMY-UHFFFAOYSA-N	332616	2-(4-(4-(2-((2-Chloro-4-(trifluoromethyl)phenyl)amino)-2-oxoethyl)-2-(3,6-dihydro-2H-pyran-4-yl)-5-ethyl-7-oxo-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)piperazin-1-yl)-2-oxo-N-(thiazol-4-yl)acetamide::US20260015358, Example 335	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		 550							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332616	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332616&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			117978913	384577329							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192616	CCNC(=O)C(=O)N1CCN(c2c(CC)n(CC(=O)Nc3ccc(C(F)(F)F)cc3Cl)c3nc(C4=CCOCC4)nn3c2=O)CC1	InChI=1S/C29H32ClF3N8O5/c1-3-21-23(38-9-11-39(12-10-38)27(45)25(43)34-4-2)26(44)41-28(36-24(37-41)17-7-13-46-14-8-17)40(21)16-22(42)35-20-6-5-18(15-19(20)30)29(31,32)33/h5-7,15H,3-4,8-14,16H2,1-2H3,(H,34,43)(H,35,42)	UQRHPJBUJYDFMR-UHFFFAOYSA-N	332617	2-(4-(4-(2-((2-Chloro-4-(trifluoromethyl)phenyl)amino)-2-oxoethyl)-2-(3,6-dihydro-2H-pyran-4-yl)-5-ethyl-7-oxo-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)piperazin-1-yl)-N-ethyl-2-oxoacetamide::US20260015358, Example 336	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		 550							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332617	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332617&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			117978995	384577330							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192617	CCC1=C(N2CCN(C(=O)C(=O)NOCc3ccccc3)CC2)C(=O)n2nc(C3=CCOCC3)nc2C1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C35H35ClF3N7O6/c1-2-24-25(19-28(47)40-27-9-8-23(18-26(27)36)35(37,38)39)31-41-30(22-10-16-51-17-11-22)42-46(31)33(49)29(24)44-12-14-45(15-13-44)34(50)32(48)43-52-20-21-6-4-3-5-7-21/h3-10,18,25H,2,11-17,19-20H2,1H3,(H,40,47)(H,43,48)	IRXOQZUQWMPRST-UHFFFAOYSA-N	332618	US20260015358, Example 337	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332618	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332618&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			117978815	384577331							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192618	CCc1c(N2CCN(C(=O)CNC(=O)CC3CCCO3)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C33H38ClF3N8O6/c1-2-25-29(43-11-9-42(10-12-43)28(48)18-38-26(46)17-22-4-3-13-51-22)31(49)45-32(40-30(41-45)20-7-14-50-15-8-20)44(25)19-27(47)39-24-6-5-21(16-23(24)34)33(35,36)37/h5-7,16,22H,2-4,8-15,17-19H2,1H3,(H,38,46)(H,39,47)	PXDSFJLMRGKNLL-UHFFFAOYSA-N	332619	N-(2-Chloro-4-(trifluoromethyl)phenyl)-2-(2-(3,6-dihydro-2H-pyran-4-yl)-5-ethyl-7-oxo-6-(4-((2-(tetrahydrofuran-2-yl)acetyl)glycyl)piperazin-1-yl)-[1,2,4]triazolo[1,5-a]pyrimidin-4(7H)-yl)acetamide::US20260015358, Example 338	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332619	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332619&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			117978843	384577332							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192619	CCc1c(N2CCN(C(=O)C(=O)Nc3ccncn3)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1F	InChI=1S/C31H30F4N10O5/c1-2-22-25(42-9-11-43(12-10-42)29(49)27(47)39-23-5-8-36-17-37-23)28(48)45-30(40-26(41-45)18-6-13-50-14-7-18)44(22)16-24(46)38-21-4-3-19(15-20(21)32)31(33,34)35/h3-6,8,15,17H,2,7,9-14,16H2,1H3,(H,38,46)(H,36,37,39,47)	HHOGIZZYGBFWHU-UHFFFAOYSA-N	332620	2-(4-(2-(3,6-Dihydro-2H-pyran-4-yl)-5-ethyl-4-(2-((2-fluoro-4-(trifluoromethyl)phenyl)amino)-2-oxoethyl)-7-oxo-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)piperazin-1-yl)-2-oxo-N-(pyrimidin-4-yl)acetamide::US20260015358, Example 340	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		 550							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332620	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332620&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			117979009	384577333							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192620	CCc1c(N2CCN(C(=O)C(=O)Nc3ccno3)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1F	InChI=1S/C30H29F4N9O6/c1-2-21-24(40-9-11-41(12-10-40)28(47)26(45)37-23-5-8-35-49-23)27(46)43-29(38-25(39-43)17-6-13-48-14-7-17)42(21)16-22(44)36-20-4-3-18(15-19(20)31)30(32,33)34/h3-6,8,15H,2,7,9-14,16H2,1H3,(H,36,44)(H,37,45)	UQWIXILQSDWPIG-UHFFFAOYSA-N	332621	2-(4-(2-(3,6-Dihydro-2H-pyran-4-yl)-5-ethyl-4-(2-((2-fluoro-4-(trifluoromethyl)phenyl)amino)-2-oxoethyl)-7-oxo-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)piperazin-1-yl)-N-(isoxazol-5-yl)-2-oxoacetamide::US20260015358, Example 341	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332621	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332621&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			117979085	384577334							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192621	CCc1c(N2CCN(C(=O)C(=O)Nc3nncs3)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1F	InChI=1S/C29H28F4N10O5S/c1-2-20-22(40-7-9-41(10-8-40)26(47)24(45)37-27-38-34-15-49-27)25(46)43-28(36-23(39-43)16-5-11-48-12-6-16)42(20)14-21(44)35-19-4-3-17(13-18(19)30)29(31,32)33/h3-5,13,15H,2,6-12,14H2,1H3,(H,35,44)(H,37,38,45)	CYXUKHXJEJIDOO-UHFFFAOYSA-N	332622	2-(4-(2-(3,6-Dihydro-2H-pyran-4-yl)-5-ethyl-4-(2-((2-fluoro-4-(trifluoromethyl)phenyl)amino)-2-oxoethyl)-7-oxo-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)piperazin-1-yl)-2-oxo-N-(1,3,4-thiadiazol-2-yl)acetamide::US20260015358, Example 342	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332622	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332622&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			117978904	384577335							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192622	CCc1c(N2CCN(C(=O)CNC(=O)c3ccccc3F)CC2)c(=O)n2nc(C3=CCOCC3)cc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C35H34ClF4N7O5/c1-2-28-32(45-13-11-44(12-14-45)31(49)19-41-33(50)23-5-3-4-6-25(23)37)34(51)47-30(18-27(43-47)21-9-15-52-16-10-21)46(28)20-29(48)42-26-8-7-22(17-24(26)36)35(38,39)40/h3-9,17-18H,2,10-16,19-20H2,1H3,(H,41,50)(H,42,48)	MIFJCJGYOKFMRL-UHFFFAOYSA-N	332623	US20260015358, Example 343	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332623	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332623&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			121410140	384577336							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192623	CCc1c(N2CCN(C(=O)CNC(=O)c3ccccc3F)CC2)c(=O)n2nc(N3CCOCC3)cc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C34H35ClF4N8O5/c1-2-26-31(45-11-9-44(10-12-45)30(49)19-40-32(50)22-5-3-4-6-24(22)36)33(51)47-29(18-27(42-47)43-13-15-52-16-14-43)46(26)20-28(48)41-25-8-7-21(17-23(25)35)34(37,38)39/h3-8,17-18H,2,9-16,19-20H2,1H3,(H,40,50)(H,41,48)	YUQTXNCZNNFIFO-UHFFFAOYSA-N	332624	N-(2-(4-(4-(2-((2-chloro-4-(trifluoromethyl)phenyl)amino)-2-oxoethyl)-5-ethyl-2-morpholino-7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidin-6-yl)piperazin-1-yl)-2-oxoethyl)-2-fluorobenzamide::US20260015358, Example 344	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		 550							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332624	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332624&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			121410131	384577337							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192624	CCc1c(N2CCN(C(=O)C(F)N3C(=O)c4ccccc4C3=O)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C35H31ClF4N8O6/c1-2-25-27(44-11-13-45(14-12-44)33(53)28(37)47-30(50)21-5-3-4-6-22(21)31(47)51)32(52)48-34(42-29(43-48)19-9-15-54-16-10-19)46(25)18-26(49)41-24-8-7-20(17-23(24)36)35(38,39)40/h3-9,17,28H,2,10-16,18H2,1H3,(H,41,49)	KRXRPYOLOFBYOS-UHFFFAOYSA-N	332625	US20260015358, Example 345	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		 550							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332625	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332625&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			121410134	384577338							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192625	CCc1c(N2CCN(C(=O)CNC(=O)c3nc(C)cs3)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C32H33ClF3N9O5S/c1-3-23-26(43-10-8-42(9-11-43)25(47)15-37-28(48)29-38-18(2)17-51-29)30(49)45-31(40-27(41-45)19-6-12-50-13-7-19)44(23)16-24(46)39-22-5-4-20(14-21(22)33)32(34,35)36/h4-6,14,17H,3,7-13,15-16H2,1-2H3,(H,37,48)(H,39,46)	GBWTUMYYFHBQRF-UHFFFAOYSA-N	332626	US20260015358, Example 346	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332626	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332626&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			117979129	384577339							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192626	CCc1c(N2CCN(C(=O)C(=O)Nc3nc(C)cs3)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C31H31ClF3N9O5S/c1-3-22-24(41-8-10-42(11-9-41)28(48)26(46)39-29-36-17(2)16-50-29)27(47)44-30(38-25(40-44)18-6-12-49-13-7-18)43(22)15-23(45)37-21-5-4-19(14-20(21)32)31(33,34)35/h4-6,14,16H,3,7-13,15H2,1-2H3,(H,37,45)(H,36,39,46)	SDPWFKWXESKUKN-UHFFFAOYSA-N	332627	2-(4-(4-(2-((2-Chloro-4-(trifluoromethyl)phenyl)amino)-2-oxoethyl)-2-(3,6-dihydro-2H-pyran-4-yl)-5-ethyl-7-oxo-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)piperazin-1-yl)-N-(4-methylthiazol-2-yl)-2-oxoacetamide::US20260015358, Example 347	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332627	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332627&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			117978894	384577340							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192627	CCc1c(N2CCN(C(=O)C(=O)Nc3cc(C)no3)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C31H31ClF3N9O6/c1-3-22-25(41-8-10-42(11-9-41)29(48)27(46)37-24-14-17(2)40-50-24)28(47)44-30(38-26(39-44)18-6-12-49-13-7-18)43(22)16-23(45)36-21-5-4-19(15-20(21)32)31(33,34)35/h4-6,14-15H,3,7-13,16H2,1-2H3,(H,36,45)(H,37,46)	WTXXBABSBBSSBG-UHFFFAOYSA-N	332628	2-(4-(4-(2-((2-Chloro-4-(trifluoromethyl)phenyl)amino)-2-oxoethyl)-2-(3,6-dihydro-2H-pyran-4-yl)-5-ethyl-7-oxo-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)piperazin-1-yl)-N-(3-methylisoxazol-5-yl)-2-oxoacetamide::US20260015358, Example 348	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332628	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332628&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			121410132	384577341							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192628	CCc1c(N2CCN(C(=O)C(=O)Nc3cncs3)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1F	InChI=1S/C30H29F4N9O5S/c1-2-21-24(40-7-9-41(10-8-40)28(47)26(45)37-23-14-35-16-49-23)27(46)43-29(38-25(39-43)17-5-11-48-12-6-17)42(21)15-22(44)36-20-4-3-18(13-19(20)31)30(32,33)34/h3-5,13-14,16H,2,6-12,15H2,1H3,(H,36,44)(H,37,45)	LPHLQRWZEULAOH-UHFFFAOYSA-N	332629	2-(4-(2-(3,6-Dihydro-2H-pyran-4-yl)-5-ethyl-4-(2-((2-fluoro-4-(trifluoromethyl)phenyl)amino)-2-oxoethyl)-7-oxo-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)piperazin-1-yl)-2-oxo-N-(thiazol-5-yl)acetamide::US20260015358, Example 349	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332629	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332629&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			117978826	384577342							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192629	CCc1c(N2CCN(C(=O)C(=O)Nc3nc(C)cs3)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1F	InChI=1S/C31H31F4N9O5S/c1-3-22-24(41-8-10-42(11-9-41)28(48)26(46)39-29-36-17(2)16-50-29)27(47)44-30(38-25(40-44)18-6-12-49-13-7-18)43(22)15-23(45)37-21-5-4-19(14-20(21)32)31(33,34)35/h4-6,14,16H,3,7-13,15H2,1-2H3,(H,37,45)(H,36,39,46)	DFODRXGTKGTLSV-UHFFFAOYSA-N	332630	2-(4-(2-(3,6-Dihydro-2H-pyran-4-yl)-5-ethyl-4-(2-((2-fluoro-4-(trifluoromethyl)phenyl)amino)-2-oxoethyl)-7-oxo-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)piperazin-1-yl)-N-(4-methylthiazol-2-yl)-2-oxoacetamide::US20260015358, Example 350	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332630	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332630&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			117978981	384577343							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192630	CCc1c(N2CCN(C(=O)C(=O)Nc3nnc(Cl)s3)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C29H27Cl2F3N10O5S/c1-2-19-21(41-7-9-42(10-8-41)25(48)23(46)37-27-39-38-26(31)50-27)24(47)44-28(36-22(40-44)15-5-11-49-12-6-15)43(19)14-20(45)35-18-4-3-16(13-17(18)30)29(32,33)34/h3-5,13H,2,6-12,14H2,1H3,(H,35,45)(H,37,39,46)	LIFKSGBJEZWODO-UHFFFAOYSA-N	332631	US20260015358, Example 351	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332631	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332631&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			117979016	384577344							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192631	CCc1c(N2CCN(C(=O)C(=O)Nc3cc(C)on3)CC2)c(=O)n2nc(N3CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C30H32ClF3N10O6/c1-3-21-24(40-6-8-41(9-7-40)27(48)25(46)36-22-14-17(2)50-39-22)26(47)44-29(37-28(38-44)42-10-12-49-13-11-42)43(21)16-23(45)35-20-5-4-18(15-19(20)31)30(32,33)34/h4-5,14-15H,3,6-13,16H2,1-2H3,(H,35,45)(H,36,39,46)	HDMCBQFVPFIAMC-UHFFFAOYSA-N	332632	2-(4-(4-(2-((2-Chloro-4-(trifluoromethyl)phenyl)amino)-2-oxoethyl)-5-ethyl-2-morpholino-7-oxo-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)piperazin-1-yl)-N-(5-methylisoxazol-3-yl)-2-oxoacetamide::US20260015358, Example 352	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		 550							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332632	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332632&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			117978868	384577345							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192632	CCc1c(N2CCN(C(=O)C(=O)Nc3nc(C)co3)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C31H31ClF3N9O6/c1-3-22-24(41-8-10-42(11-9-41)28(48)26(46)39-29-36-17(2)16-50-29)27(47)44-30(38-25(40-44)18-6-12-49-13-7-18)43(22)15-23(45)37-21-5-4-19(14-20(21)32)31(33,34)35/h4-6,14,16H,3,7-13,15H2,1-2H3,(H,37,45)(H,36,39,46)	YXXJIOLIDCCHOF-UHFFFAOYSA-N	332633	2-(4-(4-(2-((2-Chloro-4-(trifluoromethyl)phenyl)amino)-2-oxoethyl)-2-(3,6-dihydro-2H-pyran-4-yl)-5-ethyl-7-oxo-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)piperazin-1-yl)-N-(4-methyloxazol-2-yl)-2-oxoacetamide::US20260015358, Example 353	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332633	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332633&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			117979028	384577346							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192633	CCc1c(N2CCN(C(=O)C(=O)Nc3ccno3)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C30H29ClF3N9O6/c1-2-21-24(40-9-11-41(12-10-40)28(47)26(45)37-23-5-8-35-49-23)27(46)43-29(38-25(39-43)17-6-13-48-14-7-17)42(21)16-22(44)36-20-4-3-18(15-19(20)31)30(32,33)34/h3-6,8,15H,2,7,9-14,16H2,1H3,(H,36,44)(H,37,45)	BPSUVXIKQDYOEC-UHFFFAOYSA-N	332634	2-(4-(4-(2-((2-Chloro-4-(trifluoromethyl)phenyl)amino)-2-oxoethyl)-2-(3,6-dihydro-2H-pyran-4-yl)-5-ethyl-7-oxo-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)piperazin-1-yl)-N-(isoxazol-5-yl)-2-oxoacetamide::US20260015358, Example 354	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332634	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332634&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			117978901	384577347							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192634	CCc1c(N2CCN(C(=O)C(=O)Nc3nc(C)co3)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1F	InChI=1S/C31H31F4N9O6/c1-3-22-24(41-8-10-42(11-9-41)28(48)26(46)39-29-36-17(2)16-50-29)27(47)44-30(38-25(40-44)18-6-12-49-13-7-18)43(22)15-23(45)37-21-5-4-19(14-20(21)32)31(33,34)35/h4-6,14,16H,3,7-13,15H2,1-2H3,(H,37,45)(H,36,39,46)	PJESZGUJKVCINQ-UHFFFAOYSA-N	332635	2-(4-(2-(3,6-Dihydro-2H-pyran-4-yl)-5-ethyl-4-(2-((2-fluoro-4-(trifluoromethyl)phenyl)amino)-2-oxoethyl)-7-oxo-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)piperazin-1-yl)-N-(4-methyloxazol-2-yl)-2-oxoacetamide::US20260015358, Example 355	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332635	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332635&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			117979112	384577348							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192635	CCc1c(N2CCN(C(=O)C(=O)N3CCOCC3)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C31H34ClF3N8O6/c1-2-23-25(39-7-9-40(10-8-39)28(46)29(47)41-11-15-49-16-12-41)27(45)43-30(37-26(38-43)19-5-13-48-14-6-19)42(23)18-24(44)36-22-4-3-20(17-21(22)32)31(33,34)35/h3-5,17H,2,6-16,18H2,1H3,(H,36,44)	WYVDXQXBZHXFNT-UHFFFAOYSA-N	332636	US20260015358, Example 356	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		>1000							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332636	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332636&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			117979087	384577349							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192636	CCc1c(N2CCN(C(=O)C(=O)NC3CCCC3)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C32H36ClF3N8O5/c1-2-24-26(41-11-13-42(14-12-41)30(48)28(46)37-21-5-3-4-6-21)29(47)44-31(39-27(40-44)19-9-15-49-16-10-19)43(24)18-25(45)38-23-8-7-20(17-22(23)33)32(34,35)36/h7-9,17,21H,2-6,10-16,18H2,1H3,(H,37,46)(H,38,45)	YBCNRJYNHLWNMP-UHFFFAOYSA-N	332637	2-(4-(4-(2-((2-Chloro-4-(trifluoromethyl)phenyl)amino)-2-oxoethyl)-2-(3,6-dihydro-2H-pyran-4-yl)-5-ethyl-7-oxo-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)piperazin-1-yl)-N-cyclopentyl-2-oxoacetamide::US20260015358, Example 357	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		 550							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332637	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332637&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			117978991	384577350							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192637	CCc1c(N2CCN(C(=O)C(=O)N3CCCC3)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C31H34ClF3N8O5/c1-2-23-25(39-11-13-41(14-12-39)29(47)28(46)40-9-3-4-10-40)27(45)43-30(37-26(38-43)19-7-15-48-16-8-19)42(23)18-24(44)36-22-6-5-20(17-21(22)32)31(33,34)35/h5-7,17H,2-4,8-16,18H2,1H3,(H,36,44)	FTBLZGKVSJSCFF-UHFFFAOYSA-N	332638	US20260015358, Example 358	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		 550							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332638	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332638&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			117978871	384577351							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192638	CCc1c(N2CCN(C(=O)C(=O)NC3CC3)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C30H32ClF3N8O5/c1-2-22-24(39-9-11-40(12-10-39)28(46)26(44)35-19-4-5-19)27(45)42-29(37-25(38-42)17-7-13-47-14-8-17)41(22)16-23(43)36-21-6-3-18(15-20(21)31)30(32,33)34/h3,6-7,15,19H,2,4-5,8-14,16H2,1H3,(H,35,44)(H,36,43)	NSIHABILQGBKAN-UHFFFAOYSA-N	332639	2-(4-(4-(2-((2-Chloro-4-(trifluoromethyl)phenyl)amino)-2-oxoethyl)-2-(3,6-dihydro-2H-pyran-4-yl)-5-ethyl-7-oxo-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)piperazin-1-yl)-N-cyclopropyl-2-oxoacetamide::US20260015358, Example 359	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		 550							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332639	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332639&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			117979058	384577352							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192639	CCc1c(N2CCN(C(=O)C(=O)NCC(F)(F)F)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C29H29ClF6N8O5/c1-2-20-22(41-7-9-42(10-8-41)26(48)24(46)37-15-28(31,32)33)25(47)44-27(39-23(40-44)16-5-11-49-12-6-16)43(20)14-21(45)38-19-4-3-17(13-18(19)30)29(34,35)36/h3-5,13H,2,6-12,14-15H2,1H3,(H,37,46)(H,38,45)	PDOSVNRGCKNKSW-UHFFFAOYSA-N	332640	2-(4-(4-(2-((2-Chloro-4-(trifluoromethyl)phenyl)amino)-2-oxoethyl)-2-(3,6-dihydro-2H-pyran-4-yl)-5-ethyl-7-oxo-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)piperazin-1-yl)-2-oxo-N-(2,2,2-trifluoroethyl)acetamide::US20260015358, Example 360	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		>1000							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332640	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332640&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			117979078	384577353							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192640	CCc1c(N2CCN(C(=O)CNC(=O)c3nc(NC)ccc3F)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C34H35ClF4N10O5/c1-3-24-29(47-12-10-46(11-13-47)27(51)17-41-31(52)28-22(36)5-7-25(40-2)43-28)32(53)49-33(44-30(45-49)19-8-14-54-15-9-19)48(24)18-26(50)42-23-6-4-20(16-21(23)35)34(37,38)39/h4-8,16H,3,9-15,17-18H2,1-2H3,(H,40,43)(H,41,52)(H,42,50)	JVZXEXKWTJNCGQ-UHFFFAOYSA-N	332641	N-(2-(4-(4-(2-((2-Chloro-4-(trifluoromethyl)phenyl)amino)-2-oxoethyl)-2-(3,6-dihydro-2H-pyran-4-yl)-5-ethyl-7-oxo-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)piperazin-1-yl)-2-oxoethyl)-3-fluoro-6-(methylamino)picolinamide::US20260015358, Example 361	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332641	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332641&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			117979355	384577354							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192641	CCc1c(N2CCN(C(=O)CNc3ncnc4cccnc34)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C34H33ClF3N11O4/c1-2-25-29(47-12-10-46(11-13-47)27(51)17-40-31-28-24(41-19-42-31)4-3-9-39-28)32(52)49-33(44-30(45-49)20-7-14-53-15-8-20)48(25)18-26(50)43-23-6-5-21(16-22(23)35)34(36,37)38/h3-7,9,16,19H,2,8,10-15,17-18H2,1H3,(H,43,50)(H,40,41,42)	PGXYTGKAPICITP-UHFFFAOYSA-N	332642	US20260015358, Example 362	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		 550							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332642	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332642&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			117978908	384577355							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192642	CCc1c(N2CCN(C(=O)CNc3ncnc4[nH]ccc34)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C33H33ClF3N11O4/c1-2-24-27(46-11-9-45(10-12-46)26(50)16-39-30-21-5-8-38-29(21)40-18-41-30)31(51)48-32(43-28(44-48)19-6-13-52-14-7-19)47(24)17-25(49)42-23-4-3-20(15-22(23)34)33(35,36)37/h3-6,8,15,18H,2,7,9-14,16-17H2,1H3,(H,42,49)(H2,38,39,40,41)	QCHLDSPLGPRKSD-UHFFFAOYSA-N	332643	2-(6-(4-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)glycyl)piperazin-1-yl)-2-(3,6-dihydro-2H-pyran-4-yl)-5-ethyl-7-oxo-[1,2,4]triazolo[1,5-a]pyrimidin-4(7H)-yl)-N-(2-chloro-4-(trifluoromethyl)phenyl)acetamide::US20260015358, Example 363	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		>1000							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332643	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332643&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			117978928	384577356							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192643	CCc1c(N2CCN(C(=O)CNC(=O)c3ncncc3O)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C32H32ClF3N10O6/c1-2-22-27(44-9-7-43(8-10-44)25(49)15-38-29(50)26-23(47)14-37-17-39-26)30(51)46-31(41-28(42-46)18-5-11-52-12-6-18)45(22)16-24(48)40-21-4-3-19(13-20(21)33)32(34,35)36/h3-5,13-14,17,47H,2,6-12,15-16H2,1H3,(H,38,50)(H,40,48)	BYBLAVZWHQDWJK-UHFFFAOYSA-N	332644	US20260015358, Example 364	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332644	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332644&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			117978841	384577357							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192644	CCc1c(N2CCN(C(=O)CNC(=O)c3[nH]c(=O)ccc3F)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C33H32ClF4N9O6/c1-2-23-28(45-11-9-44(10-12-45)26(50)16-39-30(51)27-21(35)4-6-24(48)41-27)31(52)47-32(42-29(43-47)18-7-13-53-14-8-18)46(23)17-25(49)40-22-5-3-19(15-20(22)34)33(36,37)38/h3-7,15H,2,8-14,16-17H2,1H3,(H,39,51)(H,40,49)(H,41,48)	PHIMFHSRVPDGQU-UHFFFAOYSA-N	332645	N-(2-(4-(4-(2-((2-Chloro-4-(trifluoromethyl)phenyl)amino)-2-oxoethyl)-2-(3,6-dihydro-2H-pyran-4-yl)-5-ethyl-7-oxo-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)piperazin-1-yl)-2-oxoethyl)-3-fluoro-6-oxo-1,6-dihydropyridine-2-carboxamide::US20260015358, Example 365	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		 550							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332645	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332645&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			117979111	384577358							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192645	CCc1c(N2CCN(C(=O)CNC(=O)c3cccc(=O)[nH]3)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C33H33ClF3N9O6/c1-2-24-28(44-12-10-43(11-13-44)27(49)17-38-30(50)23-4-3-5-25(47)40-23)31(51)46-32(41-29(42-46)19-8-14-52-15-9-19)45(24)18-26(48)39-22-7-6-20(16-21(22)34)33(35,36)37/h3-8,16H,2,9-15,17-18H2,1H3,(H,38,50)(H,39,48)(H,40,47)	HMYSPYGUMBYXSC-UHFFFAOYSA-N	332646	US20260015358, Example 366	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332646	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332646&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			117978814	384577359							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192646	CCc1c(N2CCN(C(=O)CNC(=O)c3nc(N)ccc3F)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C33H33ClF4N10O5/c1-2-23-28(46-11-9-45(10-12-46)26(50)16-40-30(51)27-21(35)4-6-24(39)42-27)31(52)48-32(43-29(44-48)18-7-13-53-14-8-18)47(23)17-25(49)41-22-5-3-19(15-20(22)34)33(36,37)38/h3-7,15H,2,8-14,16-17H2,1H3,(H2,39,42)(H,40,51)(H,41,49)	WUFFAVNXHJYPDC-UHFFFAOYSA-N	332647	6-Amino-N-(2-(4-(4-(2-((2-chloro-4-(trifluoromethyl)phenyl)amino)-2-oxoethyl)-2-(3,6-dihydro-2H-pyran-4-yl)-5-ethyl-7-oxo-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)piperazin-1-yl)-2-oxoethyl)-3-fluoropicolinamide::US20260015358, Example 367	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332647	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332647&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			117978813	384577360							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192647	CCc1c(N2CCN(C(=O)CNC(=O)c3nc(C)ncc3O)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C33H34ClF3N10O6/c1-3-23-28(45-10-8-44(9-11-45)26(50)16-39-30(51)27-24(48)15-38-18(2)40-27)31(52)47-32(42-29(43-47)19-6-12-53-13-7-19)46(23)17-25(49)41-22-5-4-20(14-21(22)34)33(35,36)37/h4-6,14-15,48H,3,7-13,16-17H2,1-2H3,(H,39,51)(H,41,49)	DRAFFSWDFRCZCE-UHFFFAOYSA-N	332648	US20260015358, Example 368	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332648	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332648&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			117978976	384577361							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192648	CCc1c(N2CCN(C(=O)CNC(=O)c3ccns3)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C31H31ClF3N9O5S/c1-2-22-26(42-11-9-41(10-12-42)25(46)16-36-28(47)23-5-8-37-50-23)29(48)44-30(39-27(40-44)18-6-13-49-14-7-18)43(22)17-24(45)38-21-4-3-19(15-20(21)32)31(33,34)35/h3-6,8,15H,2,7,9-14,16-17H2,1H3,(H,36,47)(H,38,45)	UEHSNVBOWKAPHA-UHFFFAOYSA-N	361596	N-(2-(4-(4-(2-((2-Chloro-4-(trifluoromethyl)phenyl)amino)-2-oxoethyl)-2-(3,6-dihydro-2H-pyran-4-yl)-5-ethyl-7-oxo-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)piperazin-1-yl)-2-oxoethyl)isothiazole-5-carboxamide::US20260015358, Example 369	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361596	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361596&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			122648623	386400976							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192649	CCc1c(N2CCN(C(=O)CNC(=O)c3ccno3)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C31H31ClF3N9O6/c1-2-22-26(42-11-9-41(10-12-42)25(46)16-36-28(47)23-5-8-37-50-23)29(48)44-30(39-27(40-44)18-6-13-49-14-7-18)43(22)17-24(45)38-21-4-3-19(15-20(21)32)31(33,34)35/h3-6,8,15H,2,7,9-14,16-17H2,1H3,(H,36,47)(H,38,45)	QFWYYYYSAJMYGV-UHFFFAOYSA-N	361597	US20260015358, Example 370	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361597	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361597&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			122648637	386400977							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192650	CCc1c(N2CCN(C(=O)CNC(=O)c3ccon3)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C31H31ClF3N9O6/c1-2-23-26(42-10-8-41(9-11-42)25(46)16-36-28(47)22-7-14-50-40-22)29(48)44-30(38-27(39-44)18-5-12-49-13-6-18)43(23)17-24(45)37-21-4-3-19(15-20(21)32)31(33,34)35/h3-5,7,14-15H,2,6,8-13,16-17H2,1H3,(H,36,47)(H,37,45)	VXPLOGKOPRAWHN-UHFFFAOYSA-N	361598	US20260015358, Example 371	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361598	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361598&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			122648634	386400978							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192651	CCc1c(N2CCN(C(=O)CNC(=O)c3cc(N)ccc3F)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C34H34ClF4N9O5/c1-2-26-29(46-11-9-45(10-12-46)28(50)17-41-31(51)22-16-21(40)4-5-24(22)36)32(52)48-33(43-30(44-48)19-7-13-53-14-8-19)47(26)18-27(49)42-25-6-3-20(15-23(25)35)34(37,38)39/h3-7,15-16H,2,8-14,17-18,40H2,1H3,(H,41,51)(H,42,49)	LRFMXPXONJBRGH-UHFFFAOYSA-N	361599	5-Amino-N-(2-(4-(4-(2-((2-chloro-4-(trifluoromethyl)phenyl)amino)-2-oxoethyl)-2-(3,6-dihydro-2H-pyran-4-yl)-5-ethyl-7-oxo-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)piperazin-1-yl)-2-oxoethyl)-2-fluorobenzamide::US20260015358, Example 372	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361599	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361599&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			122648633	386400979							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192652	CCc1c(N2CCN(C(=O)CNC(=O)c3cc(N)c(F)cc3F)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C34H33ClF5N9O5/c1-2-26-29(47-9-7-46(8-10-47)28(51)16-42-31(52)20-14-24(41)23(37)15-22(20)36)32(53)49-33(44-30(45-49)18-5-11-54-12-6-18)48(26)17-27(50)43-25-4-3-19(13-21(25)35)34(38,39)40/h3-5,13-15H,2,6-12,16-17,41H2,1H3,(H,42,52)(H,43,50)	NRKZPXRBRHBKJP-UHFFFAOYSA-N	361600	5-Amino-N-(2-(4-(4-(2-((2-chloro-4-(trifluoromethyl)phenyl)amino)-2-oxoethyl)-2-(3,6-dihydro-2H-pyran-4-yl)-5-ethyl-7-oxo-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)piperazin-1-yl)-2-oxoethyl)-2,4-difluorobenzamide::US20260015358, Example 373	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361600	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361600&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			122648632	386400980							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192653	CCNc1ccc(F)c(C(=O)NCC(=O)N2CCN(c3c(CC)n(CC(=O)Nc4ccc(C(F)(F)F)cc4Cl)c4nc(C5=CCOCC5)nn4c3=O)CC2)c1	InChI=1S/C36H38ClF4N9O5/c1-3-28-31(48-13-11-47(12-14-48)30(52)19-43-33(53)24-18-23(42-4-2)6-7-26(24)38)34(54)50-35(45-32(46-50)21-9-15-55-16-10-21)49(28)20-29(51)44-27-8-5-22(17-25(27)37)36(39,40)41/h5-9,17-18,42H,3-4,10-16,19-20H2,1-2H3,(H,43,53)(H,44,51)	TXIVFEVFHZDJAG-UHFFFAOYSA-N	361601	US20260015358, Example 374	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361601	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361601&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			122648635	386400981							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192654	CCc1c(N2CCN(C(=O)CNC(=O)c3ccc(F)s3)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C32H31ClF4N8O5S/c1-2-22-27(43-11-9-42(10-12-43)26(47)16-38-29(48)23-5-6-24(34)51-23)30(49)45-31(40-28(41-45)18-7-13-50-14-8-18)44(22)17-25(46)39-21-4-3-19(15-20(21)33)32(35,36)37/h3-7,15H,2,8-14,16-17H2,1H3,(H,38,48)(H,39,46)	KDLNXBWBCIVAQI-UHFFFAOYSA-N	361602	US20260015358, Example 375	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361602	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361602&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			122648636	386400982							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192655	CCc1c(N2CCN(C(=O)CNC(=O)c3ccno3)CC2)c(=O)n2nc(N3CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C30H32ClF3N10O6/c1-2-21-25(41-9-7-40(8-10-41)24(46)16-35-26(47)22-5-6-36-50-22)27(48)44-29(38-28(39-44)42-11-13-49-14-12-42)43(21)17-23(45)37-20-4-3-18(15-19(20)31)30(32,33)34/h3-6,15H,2,7-14,16-17H2,1H3,(H,35,47)(H,37,45)	IWSGWZWJOXYCFK-UHFFFAOYSA-N	361603	US20260015358, Example 376	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361603	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361603&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			122648689	386400983							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192656	CCc1c(N2CCN(C(=O)CNC(=O)c3ncnc(C)c3O)CC2)c(=O)n2nc(N3CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C32H35ClF3N11O6/c1-3-22-26(44-8-6-43(7-9-44)24(49)15-37-28(51)25-27(50)18(2)38-17-39-25)29(52)47-31(41-30(42-47)45-10-12-53-13-11-45)46(22)16-23(48)40-21-5-4-19(14-20(21)33)32(34,35)36/h4-5,14,17,50H,3,6-13,15-16H2,1-2H3,(H,37,51)(H,40,48)	MDHNDJNBULMLPK-UHFFFAOYSA-N	361604	US20260015358, Example 377	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361604	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361604&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			122648678	386400984							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192657	CCc1c(N2CCN(C(=O)CNC(=O)c3cc(OC)ccc3F)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C35H35ClF4N8O6/c1-3-27-30(46-12-10-45(11-13-46)29(50)18-41-32(51)23-17-22(53-2)5-6-25(23)37)33(52)48-34(43-31(44-48)20-8-14-54-15-9-20)47(27)19-28(49)42-26-7-4-21(16-24(26)36)35(38,39)40/h4-8,16-17H,3,9-15,18-19H2,1-2H3,(H,41,51)(H,42,49)	OHYPIOGMLXQONG-UHFFFAOYSA-N	361605	N-(2-(4-(4-(2-((2-Chloro-4-(trifluoromethyl)phenyl)amino)-2-oxoethyl)-2-(3,6-dihydro-2H-pyran-4-yl)-5-ethyl-7-oxo-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)piperazin-1-yl)-2-oxoethyl)-2-fluoro-5-methoxybenzamide::US20260015358, Example 378	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361605	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361605&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			122648692	386400985							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192658	CCc1c(N2CCN(C(=O)CNC(=O)c3ccc(OC)cc3F)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C35H35ClF4N8O6/c1-3-27-30(46-12-10-45(11-13-46)29(50)18-41-32(51)23-6-5-22(53-2)17-25(23)37)33(52)48-34(43-31(44-48)20-8-14-54-15-9-20)47(27)19-28(49)42-26-7-4-21(16-24(26)36)35(38,39)40/h4-8,16-17H,3,9-15,18-19H2,1-2H3,(H,41,51)(H,42,49)	VYNXWDYHTYRDAF-UHFFFAOYSA-N	361606	US20260015358, Example 379	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361606	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361606&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			122648690	386400986							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192659	CCc1c(N2CCN(C(=O)CNC(=O)c3ccc(NC)cc3F)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C35H36ClF4N9O5/c1-3-27-30(47-12-10-46(11-13-47)29(51)18-42-32(52)23-6-5-22(41-2)17-25(23)37)33(53)49-34(44-31(45-49)20-8-14-54-15-9-20)48(27)19-28(50)43-26-7-4-21(16-24(26)36)35(38,39)40/h4-8,16-17,41H,3,9-15,18-19H2,1-2H3,(H,42,52)(H,43,50)	MTQXPWZJUNRRPB-UHFFFAOYSA-N	361607	US20260015358, Example 380	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		 550							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361607	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361607&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			122648675	386400987							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192660	CCc1c(N2CCN(C(=O)CNC(=O)c3ccncc3O)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C33H33ClF3N9O6/c1-2-24-28(44-11-9-43(10-12-44)27(49)17-39-30(50)21-5-8-38-16-25(21)47)31(51)46-32(41-29(42-46)19-6-13-52-14-7-19)45(24)18-26(48)40-23-4-3-20(15-22(23)34)33(35,36)37/h3-6,8,15-16,47H,2,7,9-14,17-18H2,1H3,(H,39,50)(H,40,48)	UHAJRZCTFNSWFE-UHFFFAOYSA-N	361608	US20260015358, Example 381	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361608	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361608&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			122648687	386400988							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192661	CCc1c(N2CCN(C(=O)CNC(=O)c3cc(C#N)ccc3F)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C35H32ClF4N9O5/c1-2-27-30(47-11-9-46(10-12-47)29(51)18-42-32(52)23-15-20(17-41)3-5-25(23)37)33(53)49-34(44-31(45-49)21-7-13-54-14-8-21)48(27)19-28(50)43-26-6-4-22(16-24(26)36)35(38,39)40/h3-7,15-16H,2,8-14,18-19H2,1H3,(H,42,52)(H,43,50)	VLUYSBOVWONVAY-UHFFFAOYSA-N	361609	US20260015358, Example 382	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361609	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361609&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			122648693	386400989							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192662	CCc1c(N2CCN(C(=O)CNC(=O)c3cccc4nonc34)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C34H32ClF3N10O6/c1-2-25-29(46-12-10-45(11-13-46)27(50)17-39-31(51)21-4-3-5-24-28(21)44-54-43-24)32(52)48-33(41-30(42-48)19-8-14-53-15-9-19)47(25)18-26(49)40-23-7-6-20(16-22(23)35)34(36,37)38/h3-8,16H,2,9-15,17-18H2,1H3,(H,39,51)(H,40,49)	SDMRQAPNSJXCEM-UHFFFAOYSA-N	361610	US20260015358, Example 383	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361610	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361610&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			122648615	386400990							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192663	CCc1c(N2CCN(C(=O)CNC(=O)c3cnon3)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C30H30ClF3N10O6/c1-2-22-25(42-9-7-41(8-10-42)24(46)15-35-27(47)21-14-36-50-40-21)28(48)44-29(38-26(39-44)17-5-11-49-12-6-17)43(22)16-23(45)37-20-4-3-18(13-19(20)31)30(32,33)34/h3-5,13-14H,2,6-12,15-16H2,1H3,(H,35,47)(H,37,45)	VOIFVJBVVOCGEK-UHFFFAOYSA-N	361611	US20260015358, Example 384	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361611	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361611&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			122648691	386400991							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192664	CCc1c(N2CCN(C(=O)CNC(=O)c3ccco3)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C32H32ClF3N8O6/c1-2-23-27(42-11-9-41(10-12-42)26(46)17-37-29(47)24-4-3-13-50-24)30(48)44-31(39-28(40-44)19-7-14-49-15-8-19)43(23)18-25(45)38-22-6-5-20(16-21(22)33)32(34,35)36/h3-7,13,16H,2,8-12,14-15,17-18H2,1H3,(H,37,47)(H,38,45)	NVKCWKXTHABFFC-UHFFFAOYSA-N	361612	US20260015358, Example 385	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361612	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361612&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			122648688	386400992							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
192665	CCc1c(N2CCN(C(=O)CNC(=O)c3ccco3)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl	InChI=1S/C32H32ClF3N8O6/c1-2-23-27(42-11-9-41(10-12-42)26(46)17-37-29(47)24-4-3-13-50-24)30(48)44-31(39-28(40-44)19-7-14-49-15-8-19)43(23)18-25(45)38-22-6-5-20(16-21(22)33)32(34,35)36/h3-7,13,16H,2,8-12,14-15,17-18H2,1H3,(H,37,47)(H,38,45)	NVKCWKXTHABFFC-UHFFFAOYSA-N	361613	US20260015358, Example 386	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	Homo sapiens		<100							US Patent		10.7270/Q2GB28VP			US20260015358	ZHOU, W; ZHUO, J; ZHANG, J	1/15/2026	5/29/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361613	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006428&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361613&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN&column=ki&startPg=0&Increment=50&submit=Search			122648676	386400993							1	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9HZG,10AP,9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,10AK,8YLE,10AJ,7GQU,7GQT,7GQS,9S1A,9S19,9S17,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9