BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Date of publication Date in BindingDB Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID PubChem SID ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence 1 PDB ID(s) of Target Chain 1 UniProt (SwissProt) Recommended Name of Target Chain 1 UniProt (SwissProt) Entry Name of Target Chain 1 UniProt (SwissProt) Primary ID of Target Chain 1 UniProt (SwissProt) Secondary ID(s) of Target Chain 1 UniProt (SwissProt) Alternative ID(s) of Target Chain 1 UniProt (TrEMBL) Submitted Name of Target Chain 1 UniProt (TrEMBL) Entry Name of Target Chain 1 UniProt (TrEMBL) Primary ID of Target Chain 1 UniProt (TrEMBL) Secondary ID(s) of Target Chain 1 UniProt (TrEMBL) Alternative ID(s) of Target Chain 1 BindingDB Target Chain Sequence 2 PDB ID(s) of Target Chain 2 UniProt (SwissProt) Recommended Name of Target Chain 2 UniProt (SwissProt) Entry Name of Target Chain 2 UniProt (SwissProt) Primary ID of Target Chain 2 UniProt (SwissProt) Secondary ID(s) of Target Chain 2 UniProt (SwissProt) Alternative ID(s) of Target Chain 2 UniProt (TrEMBL) Submitted Name of Target Chain 2 UniProt (TrEMBL) Entry Name of Target Chain 2 UniProt (TrEMBL) Primary ID of Target Chain 2 UniProt (TrEMBL) Secondary ID(s) of Target Chain 2 UniProt (TrEMBL) Alternative ID(s) of Target Chain 2 BindingDB Target Chain Sequence 3 PDB ID(s) of Target Chain 3 UniProt (SwissProt) Recommended Name of Target Chain 3 UniProt (SwissProt) Entry Name of Target Chain 3 UniProt (SwissProt) Primary ID of Target Chain 3 UniProt (SwissProt) Secondary ID(s) of Target Chain 3 UniProt (SwissProt) Alternative ID(s) of Target Chain 3 UniProt (TrEMBL) Submitted Name of Target Chain 3 UniProt (TrEMBL) Entry Name of Target Chain 3 UniProt (TrEMBL) Primary ID of Target Chain 3 UniProt (TrEMBL) Secondary ID(s) of Target Chain 3 UniProt (TrEMBL) Alternative ID(s) of Target Chain 3 BindingDB Target Chain Sequence 4 PDB ID(s) of Target Chain 4 UniProt (SwissProt) Recommended Name of Target Chain 4 UniProt (SwissProt) Entry Name of Target Chain 4 UniProt (SwissProt) Primary ID of Target Chain 4 UniProt (SwissProt) Secondary ID(s) of Target Chain 4 UniProt (SwissProt) Alternative ID(s) of Target Chain 4 UniProt (TrEMBL) Submitted Name of Target Chain 4 UniProt (TrEMBL) Entry Name of Target Chain 4 UniProt (TrEMBL) Primary ID of Target Chain 4 UniProt (TrEMBL) Secondary ID(s) of Target Chain 4 UniProt (TrEMBL) Alternative ID(s) of Target Chain 4 BindingDB Target Chain Sequence 5 PDB ID(s) of Target Chain 5 UniProt (SwissProt) Recommended Name of Target Chain 5 UniProt (SwissProt) Entry Name of Target Chain 5 UniProt (SwissProt) Primary ID of Target Chain 5 UniProt (SwissProt) Secondary ID(s) of Target Chain 5 UniProt (SwissProt) Alternative ID(s) of Target Chain 5 UniProt (TrEMBL) Submitted Name of Target Chain 5 UniProt (TrEMBL) Entry Name of Target Chain 5 UniProt (TrEMBL) Primary ID of Target Chain 5 UniProt (TrEMBL) Secondary ID(s) of Target Chain 5 UniProt (TrEMBL) Alternative ID(s) of Target Chain 5 BindingDB Target Chain Sequence 6 PDB ID(s) of Target Chain 6 UniProt (SwissProt) Recommended Name of Target Chain 6 UniProt (SwissProt) Entry Name of Target Chain 6 UniProt (SwissProt) Primary ID of Target Chain 6 UniProt (SwissProt) Secondary ID(s) of Target Chain 6 UniProt (SwissProt) Alternative ID(s) of Target Chain 6 UniProt (TrEMBL) Submitted Name of Target Chain 6 UniProt (TrEMBL) Entry Name of Target Chain 6 UniProt (TrEMBL) Primary ID of Target Chain 6 UniProt (TrEMBL) Secondary ID(s) of Target Chain 6 UniProt (TrEMBL) Alternative ID(s) of Target Chain 6 BindingDB Target Chain Sequence 7 PDB ID(s) of Target Chain 7 UniProt (SwissProt) Recommended Name of Target Chain 7 UniProt (SwissProt) Entry Name of Target Chain 7 UniProt (SwissProt) Primary ID of Target Chain 7 UniProt (SwissProt) Secondary ID(s) of Target Chain 7 UniProt (SwissProt) Alternative ID(s) of Target Chain 7 UniProt (TrEMBL) Submitted Name of Target Chain 7 UniProt (TrEMBL) Entry Name of Target Chain 7 UniProt (TrEMBL) Primary ID of Target Chain 7 UniProt (TrEMBL) Secondary ID(s) of Target Chain 7 UniProt (TrEMBL) Alternative ID(s) of Target Chain 7 BindingDB Target Chain Sequence 8 PDB ID(s) of Target Chain 8 UniProt (SwissProt) Recommended Name of Target Chain 8 UniProt (SwissProt) Entry Name of Target Chain 8 UniProt (SwissProt) Primary ID of Target Chain 8 UniProt (SwissProt) Secondary ID(s) of Target Chain 8 UniProt (SwissProt) Alternative ID(s) of Target Chain 8 UniProt (TrEMBL) Submitted Name of Target Chain 8 UniProt (TrEMBL) Entry Name of Target Chain 8 UniProt (TrEMBL) Primary ID of Target Chain 8 UniProt (TrEMBL) Secondary ID(s) of Target Chain 8 UniProt (TrEMBL) Alternative ID(s) of Target Chain 8 BindingDB Target Chain Sequence 9 PDB ID(s) of Target Chain 9 UniProt (SwissProt) Recommended Name of Target Chain 9 UniProt (SwissProt) Entry Name of Target Chain 9 UniProt (SwissProt) Primary ID of Target Chain 9 UniProt (SwissProt) Secondary ID(s) of Target Chain 9 UniProt (SwissProt) Alternative ID(s) of Target Chain 9 UniProt (TrEMBL) Submitted Name of Target Chain 9 UniProt (TrEMBL) Entry Name of Target Chain 9 UniProt (TrEMBL) Primary ID of Target Chain 9 UniProt (TrEMBL) Secondary ID(s) of Target Chain 9 UniProt (TrEMBL) Alternative ID(s) of Target Chain 9 BindingDB Target Chain Sequence 10 PDB ID(s) of Target Chain 10 UniProt (SwissProt) Recommended Name of Target Chain 10 UniProt (SwissProt) Entry Name of Target Chain 10 UniProt (SwissProt) Primary ID of Target Chain 10 UniProt (SwissProt) Secondary ID(s) of Target Chain 10 UniProt (SwissProt) Alternative ID(s) of Target Chain 10 UniProt (TrEMBL) Submitted Name of Target Chain 10 UniProt (TrEMBL) Entry Name of Target Chain 10 UniProt (TrEMBL) Primary ID of Target Chain 10 UniProt (TrEMBL) Secondary ID(s) of Target Chain 10 UniProt (TrEMBL) Alternative ID(s) of Target Chain 10 BindingDB Target Chain Sequence 11 PDB ID(s) of Target Chain 11 UniProt (SwissProt) Recommended Name of Target Chain 11 UniProt (SwissProt) Entry Name of Target Chain 11 UniProt (SwissProt) Primary ID of Target Chain 11 UniProt (SwissProt) Secondary ID(s) of Target Chain 11 UniProt (SwissProt) Alternative ID(s) of Target Chain 11 UniProt (TrEMBL) Submitted Name of Target Chain 11 UniProt (TrEMBL) Entry Name of Target Chain 11 UniProt (TrEMBL) Primary ID of Target Chain 11 UniProt (TrEMBL) Secondary ID(s) of Target Chain 11 UniProt (TrEMBL) Alternative ID(s) of Target Chain 11 BindingDB Target Chain Sequence 12 PDB ID(s) of Target Chain 12 UniProt (SwissProt) Recommended Name of Target Chain 12 UniProt (SwissProt) Entry Name of Target Chain 12 UniProt (SwissProt) Primary ID of Target Chain 12 UniProt (SwissProt) Secondary ID(s) of Target Chain 12 UniProt (SwissProt) Alternative ID(s) of Target Chain 12 UniProt (TrEMBL) Submitted Name of Target Chain 12 UniProt (TrEMBL) Entry Name of Target Chain 12 UniProt (TrEMBL) Primary ID of Target Chain 12 UniProt (TrEMBL) Secondary ID(s) of Target Chain 12 UniProt (TrEMBL) Alternative ID(s) of Target Chain 12 BindingDB Target Chain Sequence 13 PDB ID(s) of Target Chain 13 UniProt (SwissProt) Recommended Name of Target Chain 13 UniProt (SwissProt) Entry Name of Target Chain 13 UniProt (SwissProt) Primary ID of Target Chain 13 UniProt (SwissProt) Secondary ID(s) of Target Chain 13 UniProt (SwissProt) Alternative ID(s) of Target Chain 13 UniProt (TrEMBL) Submitted Name of Target Chain 13 UniProt (TrEMBL) Entry Name of Target Chain 13 UniProt (TrEMBL) Primary ID of Target Chain 13 UniProt (TrEMBL) Secondary ID(s) of Target Chain 13 UniProt (TrEMBL) Alternative ID(s) of Target Chain 13 BindingDB Target Chain Sequence 14 PDB ID(s) of Target Chain 14 UniProt (SwissProt) Recommended Name of Target Chain 14 UniProt (SwissProt) Entry Name of Target Chain 14 UniProt (SwissProt) Primary ID of Target Chain 14 UniProt (SwissProt) Secondary ID(s) of Target Chain 14 UniProt (SwissProt) Alternative ID(s) of Target Chain 14 UniProt (TrEMBL) Submitted Name of Target Chain 14 UniProt (TrEMBL) Entry Name of Target Chain 14 UniProt (TrEMBL) Primary ID of Target Chain 14 UniProt (TrEMBL) Secondary ID(s) of Target Chain 14 UniProt (TrEMBL) Alternative ID(s) of Target Chain 14 BindingDB Target Chain Sequence 15 PDB ID(s) of Target Chain 15 UniProt (SwissProt) Recommended Name of Target Chain 15 UniProt (SwissProt) Entry Name of Target Chain 15 UniProt (SwissProt) Primary ID of Target Chain 15 UniProt (SwissProt) Secondary ID(s) of Target Chain 15 UniProt (SwissProt) Alternative ID(s) of Target Chain 15 UniProt (TrEMBL) Submitted Name of Target Chain 15 UniProt (TrEMBL) Entry Name of Target Chain 15 UniProt (TrEMBL) Primary ID of Target Chain 15 UniProt (TrEMBL) Secondary ID(s) of Target Chain 15 UniProt (TrEMBL) Alternative ID(s) of Target Chain 15 BindingDB Target Chain Sequence 16 PDB ID(s) of Target Chain 16 UniProt (SwissProt) Recommended Name of Target Chain 16 UniProt (SwissProt) Entry Name of Target Chain 16 UniProt (SwissProt) Primary ID of Target Chain 16 UniProt (SwissProt) Secondary ID(s) of Target Chain 16 UniProt (SwissProt) Alternative ID(s) of Target Chain 16 UniProt (TrEMBL) Submitted Name of Target Chain 16 UniProt (TrEMBL) Entry Name of Target Chain 16 UniProt (TrEMBL) Primary ID of Target Chain 16 UniProt (TrEMBL) Secondary ID(s) of Target Chain 16 UniProt (TrEMBL) Alternative ID(s) of Target Chain 16 BindingDB Target Chain Sequence 17 PDB ID(s) of Target Chain 17 UniProt (SwissProt) Recommended Name of Target Chain 17 UniProt (SwissProt) Entry Name of Target Chain 17 UniProt (SwissProt) Primary ID of Target Chain 17 UniProt (SwissProt) Secondary ID(s) of Target Chain 17 UniProt (SwissProt) Alternative ID(s) of Target Chain 17 UniProt (TrEMBL) Submitted Name of Target Chain 17 UniProt (TrEMBL) Entry Name of Target Chain 17 UniProt (TrEMBL) Primary ID of Target Chain 17 UniProt (TrEMBL) Secondary ID(s) of Target Chain 17 UniProt (TrEMBL) Alternative ID(s) of Target Chain 17 BindingDB Target Chain Sequence 18 PDB ID(s) of Target Chain 18 UniProt (SwissProt) Recommended Name of Target Chain 18 UniProt (SwissProt) Entry Name of Target Chain 18 UniProt (SwissProt) Primary ID of Target Chain 18 UniProt (SwissProt) Secondary ID(s) of Target Chain 18 UniProt (SwissProt) Alternative ID(s) of Target Chain 18 UniProt (TrEMBL) Submitted Name of Target Chain 18 UniProt (TrEMBL) Entry Name of Target Chain 18 UniProt (TrEMBL) Primary ID of Target Chain 18 UniProt (TrEMBL) Secondary ID(s) of Target Chain 18 UniProt (TrEMBL) Alternative ID(s) of Target Chain 18 BindingDB Target Chain Sequence 19 PDB ID(s) of Target Chain 19 UniProt (SwissProt) Recommended Name of Target Chain 19 UniProt (SwissProt) Entry Name of Target Chain 19 UniProt (SwissProt) Primary ID of Target Chain 19 UniProt (SwissProt) Secondary ID(s) of Target Chain 19 UniProt (SwissProt) Alternative ID(s) of Target Chain 19 UniProt (TrEMBL) Submitted Name of Target Chain 19 UniProt (TrEMBL) Entry Name of Target Chain 19 UniProt (TrEMBL) Primary ID of Target Chain 19 UniProt (TrEMBL) Secondary ID(s) of Target Chain 19 UniProt (TrEMBL) Alternative ID(s) of Target Chain 19 BindingDB Target Chain Sequence 20 PDB ID(s) of Target Chain 20 UniProt (SwissProt) Recommended Name of Target Chain 20 UniProt (SwissProt) Entry Name of Target Chain 20 UniProt (SwissProt) Primary ID of Target Chain 20 UniProt (SwissProt) Secondary ID(s) of Target Chain 20 UniProt (SwissProt) Alternative ID(s) of Target Chain 20 UniProt (TrEMBL) Submitted Name of Target Chain 20 UniProt (TrEMBL) Entry Name of Target Chain 20 UniProt (TrEMBL) Primary ID of Target Chain 20 UniProt (TrEMBL) Secondary ID(s) of Target Chain 20 UniProt (TrEMBL) Alternative ID(s) of Target Chain 20 BindingDB Target Chain Sequence 21 PDB ID(s) of Target Chain 21 UniProt (SwissProt) Recommended Name of Target Chain 21 UniProt (SwissProt) Entry Name of Target Chain 21 UniProt (SwissProt) Primary ID of Target Chain 21 UniProt (SwissProt) Secondary ID(s) of Target Chain 21 UniProt (SwissProt) Alternative ID(s) of Target Chain 21 UniProt (TrEMBL) Submitted Name of Target Chain 21 UniProt (TrEMBL) Entry Name of Target Chain 21 UniProt (TrEMBL) Primary ID of Target Chain 21 UniProt (TrEMBL) Secondary ID(s) of Target Chain 21 UniProt (TrEMBL) Alternative ID(s) of Target Chain 21 BindingDB Target Chain Sequence 22 PDB ID(s) of Target Chain 22 UniProt (SwissProt) Recommended Name of Target Chain 22 UniProt (SwissProt) Entry Name of Target Chain 22 UniProt (SwissProt) Primary ID of Target Chain 22 UniProt (SwissProt) Secondary ID(s) of Target Chain 22 UniProt (SwissProt) Alternative ID(s) of Target Chain 22 UniProt (TrEMBL) Submitted Name of Target Chain 22 UniProt (TrEMBL) Entry Name of Target Chain 22 UniProt (TrEMBL) Primary ID of Target Chain 22 UniProt (TrEMBL) Secondary ID(s) of Target Chain 22 UniProt (TrEMBL) Alternative ID(s) of Target Chain 22 BindingDB Target Chain Sequence 23 PDB ID(s) of Target Chain 23 UniProt (SwissProt) Recommended Name of Target Chain 23 UniProt (SwissProt) Entry Name of Target Chain 23 UniProt (SwissProt) Primary ID of Target Chain 23 UniProt (SwissProt) Secondary ID(s) of Target Chain 23 UniProt (SwissProt) Alternative ID(s) of Target Chain 23 UniProt (TrEMBL) Submitted Name of Target Chain 23 UniProt (TrEMBL) Entry Name of Target Chain 23 UniProt (TrEMBL) Primary ID of Target Chain 23 UniProt (TrEMBL) Secondary ID(s) of Target Chain 23 UniProt (TrEMBL) Alternative ID(s) of Target Chain 23 BindingDB Target Chain Sequence 24 PDB ID(s) of Target Chain 24 UniProt (SwissProt) Recommended Name of Target Chain 24 UniProt (SwissProt) Entry Name of Target Chain 24 UniProt (SwissProt) Primary ID of Target Chain 24 UniProt (SwissProt) Secondary ID(s) of Target Chain 24 UniProt (SwissProt) Alternative ID(s) of Target Chain 24 UniProt (TrEMBL) Submitted Name of Target Chain 24 UniProt (TrEMBL) Entry Name of Target Chain 24 UniProt (TrEMBL) Primary ID of Target Chain 24 UniProt (TrEMBL) Secondary ID(s) of Target Chain 24 UniProt (TrEMBL) Alternative ID(s) of Target Chain 24 BindingDB Target Chain Sequence 25 PDB ID(s) of Target Chain 25 UniProt (SwissProt) Recommended Name of Target Chain 25 UniProt (SwissProt) Entry Name of Target Chain 25 UniProt (SwissProt) Primary ID of Target Chain 25 UniProt (SwissProt) Secondary ID(s) of Target Chain 25 UniProt (SwissProt) Alternative ID(s) of Target Chain 25 UniProt (TrEMBL) Submitted Name of Target Chain 25 UniProt (TrEMBL) Entry Name of Target Chain 25 UniProt (TrEMBL) Primary ID of Target Chain 25 UniProt (TrEMBL) Secondary ID(s) of Target Chain 25 UniProt (TrEMBL) Alternative ID(s) of Target Chain 25 BindingDB Target Chain Sequence 26 PDB ID(s) of Target Chain 26 UniProt (SwissProt) Recommended Name of Target Chain 26 UniProt (SwissProt) Entry Name of Target Chain 26 UniProt (SwissProt) Primary ID of Target Chain 26 UniProt (SwissProt) Secondary ID(s) of Target Chain 26 UniProt (SwissProt) Alternative ID(s) of Target Chain 26 UniProt (TrEMBL) Submitted Name of Target Chain 26 UniProt (TrEMBL) Entry Name of Target Chain 26 UniProt (TrEMBL) Primary ID of Target Chain 26 UniProt (TrEMBL) Secondary ID(s) of Target Chain 26 UniProt (TrEMBL) Alternative ID(s) of Target Chain 26 BindingDB Target Chain Sequence 27 PDB ID(s) of Target Chain 27 UniProt (SwissProt) Recommended Name of Target Chain 27 UniProt (SwissProt) Entry Name of Target Chain 27 UniProt (SwissProt) Primary ID of Target Chain 27 UniProt (SwissProt) Secondary ID(s) of Target Chain 27 UniProt (SwissProt) Alternative ID(s) of Target Chain 27 UniProt (TrEMBL) Submitted Name of Target Chain 27 UniProt (TrEMBL) Entry Name of Target Chain 27 UniProt (TrEMBL) Primary ID of Target Chain 27 UniProt (TrEMBL) Secondary ID(s) of Target Chain 27 UniProt (TrEMBL) Alternative ID(s) of Target Chain 27 BindingDB Target Chain Sequence 28 PDB ID(s) of Target Chain 28 UniProt (SwissProt) Recommended Name of Target Chain 28 UniProt (SwissProt) Entry Name of Target Chain 28 UniProt (SwissProt) Primary ID of Target Chain 28 UniProt (SwissProt) Secondary ID(s) of Target Chain 28 UniProt (SwissProt) Alternative ID(s) of Target Chain 28 UniProt (TrEMBL) Submitted Name of Target Chain 28 UniProt (TrEMBL) Entry Name of Target Chain 28 UniProt (TrEMBL) Primary ID of Target Chain 28 UniProt (TrEMBL) Secondary ID(s) of Target Chain 28 UniProt (TrEMBL) Alternative ID(s) of Target Chain 28 BindingDB Target Chain Sequence 29 PDB ID(s) of Target Chain 29 UniProt (SwissProt) Recommended Name of Target Chain 29 UniProt (SwissProt) Entry Name of Target Chain 29 UniProt (SwissProt) Primary ID of Target Chain 29 UniProt (SwissProt) Secondary ID(s) of Target Chain 29 UniProt (SwissProt) Alternative ID(s) of Target Chain 29 UniProt (TrEMBL) Submitted Name of Target Chain 29 UniProt (TrEMBL) Entry Name of Target Chain 29 UniProt (TrEMBL) Primary ID of Target Chain 29 UniProt (TrEMBL) Secondary ID(s) of Target Chain 29 UniProt (TrEMBL) Alternative ID(s) of Target Chain 29 BindingDB Target Chain Sequence 30 PDB ID(s) of Target Chain 30 UniProt (SwissProt) Recommended Name of Target Chain 30 UniProt (SwissProt) Entry Name of Target Chain 30 UniProt (SwissProt) Primary ID of Target Chain 30 UniProt (SwissProt) Secondary ID(s) of Target Chain 30 UniProt (SwissProt) Alternative ID(s) of Target Chain 30 UniProt (TrEMBL) Submitted Name of Target Chain 30 UniProt (TrEMBL) Entry Name of Target Chain 30 UniProt (TrEMBL) Primary ID of Target Chain 30 UniProt (TrEMBL) Secondary ID(s) of Target Chain 30 UniProt (TrEMBL) Alternative ID(s) of Target Chain 30 BindingDB Target Chain Sequence 31 PDB ID(s) of Target Chain 31 UniProt (SwissProt) Recommended Name of Target Chain 31 UniProt (SwissProt) Entry Name of Target Chain 31 UniProt (SwissProt) Primary ID of Target Chain 31 UniProt (SwissProt) Secondary ID(s) of Target Chain 31 UniProt (SwissProt) Alternative ID(s) of Target Chain 31 UniProt (TrEMBL) Submitted Name of Target Chain 31 UniProt (TrEMBL) Entry Name of Target Chain 31 UniProt (TrEMBL) Primary ID of Target Chain 31 UniProt (TrEMBL) Secondary ID(s) of Target Chain 31 UniProt (TrEMBL) Alternative ID(s) of Target Chain 31 BindingDB Target Chain Sequence 32 PDB ID(s) of Target Chain 32 UniProt (SwissProt) Recommended Name of Target Chain 32 UniProt (SwissProt) Entry Name of Target Chain 32 UniProt (SwissProt) Primary ID of Target Chain 32 UniProt (SwissProt) Secondary ID(s) of Target Chain 32 UniProt (SwissProt) Alternative ID(s) of Target Chain 32 UniProt (TrEMBL) Submitted Name of Target Chain 32 UniProt (TrEMBL) Entry Name of Target Chain 32 UniProt (TrEMBL) Primary ID of Target Chain 32 UniProt (TrEMBL) Secondary ID(s) of Target Chain 32 UniProt (TrEMBL) Alternative ID(s) of Target Chain 32 BindingDB Target Chain Sequence 33 PDB ID(s) of Target Chain 33 UniProt (SwissProt) Recommended Name of Target Chain 33 UniProt (SwissProt) Entry Name of Target Chain 33 UniProt (SwissProt) Primary ID of Target Chain 33 UniProt (SwissProt) Secondary ID(s) of Target Chain 33 UniProt (SwissProt) Alternative ID(s) of Target Chain 33 UniProt (TrEMBL) Submitted Name of Target Chain 33 UniProt (TrEMBL) Entry Name of Target Chain 33 UniProt (TrEMBL) Primary ID of Target Chain 33 UniProt (TrEMBL) Secondary ID(s) of Target Chain 33 UniProt (TrEMBL) Alternative ID(s) of Target Chain 33 BindingDB Target Chain Sequence 34 PDB ID(s) of Target Chain 34 UniProt (SwissProt) Recommended Name of Target Chain 34 UniProt (SwissProt) Entry Name of Target Chain 34 UniProt (SwissProt) Primary ID of Target Chain 34 UniProt (SwissProt) Secondary ID(s) of Target Chain 34 UniProt (SwissProt) Alternative ID(s) of Target Chain 34 UniProt (TrEMBL) Submitted Name of Target Chain 34 UniProt (TrEMBL) Entry Name of Target Chain 34 UniProt (TrEMBL) Primary ID of Target Chain 34 UniProt (TrEMBL) Secondary ID(s) of Target Chain 34 UniProt (TrEMBL) Alternative ID(s) of Target Chain 34 BindingDB Target Chain Sequence 35 PDB ID(s) of Target Chain 35 UniProt (SwissProt) Recommended Name of Target Chain 35 UniProt (SwissProt) Entry Name of Target Chain 35 UniProt (SwissProt) Primary ID of Target Chain 35 UniProt (SwissProt) Secondary ID(s) of Target Chain 35 UniProt (SwissProt) Alternative ID(s) of Target Chain 35 UniProt (TrEMBL) Submitted Name of Target Chain 35 UniProt (TrEMBL) Entry Name of Target Chain 35 UniProt (TrEMBL) Primary ID of Target Chain 35 UniProt (TrEMBL) Secondary ID(s) of Target Chain 35 UniProt (TrEMBL) Alternative ID(s) of Target Chain 35 BindingDB Target Chain Sequence 36 PDB ID(s) of Target Chain 36 UniProt (SwissProt) Recommended Name of Target Chain 36 UniProt (SwissProt) Entry Name of Target Chain 36 UniProt (SwissProt) Primary ID of Target Chain 36 UniProt (SwissProt) Secondary ID(s) of Target Chain 36 UniProt (SwissProt) Alternative ID(s) of Target Chain 36 UniProt (TrEMBL) Submitted Name of Target Chain 36 UniProt (TrEMBL) Entry Name of Target Chain 36 UniProt (TrEMBL) Primary ID of Target Chain 36 UniProt (TrEMBL) Secondary ID(s) of Target Chain 36 UniProt (TrEMBL) Alternative ID(s) of Target Chain 36 BindingDB Target Chain Sequence 37 PDB ID(s) of Target Chain 37 UniProt (SwissProt) Recommended Name of Target Chain 37 UniProt (SwissProt) Entry Name of Target Chain 37 UniProt (SwissProt) Primary ID of Target Chain 37 UniProt (SwissProt) Secondary ID(s) of Target Chain 37 UniProt (SwissProt) Alternative ID(s) of Target Chain 37 UniProt (TrEMBL) Submitted Name of Target Chain 37 UniProt (TrEMBL) Entry Name of Target Chain 37 UniProt (TrEMBL) Primary ID of Target Chain 37 UniProt (TrEMBL) Secondary ID(s) of Target Chain 37 UniProt (TrEMBL) Alternative ID(s) of Target Chain 37 BindingDB Target Chain Sequence 38 PDB ID(s) of Target Chain 38 UniProt (SwissProt) Recommended Name of Target Chain 38 UniProt (SwissProt) Entry Name of Target Chain 38 UniProt (SwissProt) Primary ID of Target Chain 38 UniProt (SwissProt) Secondary ID(s) of Target Chain 38 UniProt (SwissProt) Alternative ID(s) of Target Chain 38 UniProt (TrEMBL) Submitted Name of Target Chain 38 UniProt (TrEMBL) Entry Name of Target Chain 38 UniProt (TrEMBL) Primary ID of Target Chain 38 UniProt (TrEMBL) Secondary ID(s) of Target Chain 38 UniProt (TrEMBL) Alternative ID(s) of Target Chain 38 BindingDB Target Chain Sequence 39 PDB ID(s) of Target Chain 39 UniProt (SwissProt) Recommended Name of Target Chain 39 UniProt (SwissProt) Entry Name of Target Chain 39 UniProt (SwissProt) Primary ID of Target Chain 39 UniProt (SwissProt) Secondary ID(s) of Target Chain 39 UniProt (SwissProt) Alternative ID(s) of Target Chain 39 UniProt (TrEMBL) Submitted Name of Target Chain 39 UniProt (TrEMBL) Entry Name of Target Chain 39 UniProt (TrEMBL) Primary ID of Target Chain 39 UniProt (TrEMBL) Secondary ID(s) of Target Chain 39 UniProt (TrEMBL) Alternative ID(s) of Target Chain 39 BindingDB Target Chain Sequence 40 PDB ID(s) of Target Chain 40 UniProt (SwissProt) Recommended Name of Target Chain 40 UniProt (SwissProt) Entry Name of Target Chain 40 UniProt (SwissProt) Primary ID of Target Chain 40 UniProt (SwissProt) Secondary ID(s) of Target Chain 40 UniProt (SwissProt) Alternative ID(s) of Target Chain 40 UniProt (TrEMBL) Submitted Name of Target Chain 40 UniProt (TrEMBL) Entry Name of Target Chain 40 UniProt (TrEMBL) Primary ID of Target Chain 40 UniProt (TrEMBL) Secondary ID(s) of Target Chain 40 UniProt (TrEMBL) Alternative ID(s) of Target Chain 40 BindingDB Target Chain Sequence 41 PDB ID(s) of Target Chain 41 UniProt (SwissProt) Recommended Name of Target Chain 41 UniProt (SwissProt) Entry Name of Target Chain 41 UniProt (SwissProt) Primary ID of Target Chain 41 UniProt (SwissProt) Secondary ID(s) of Target Chain 41 UniProt (SwissProt) Alternative ID(s) of Target Chain 41 UniProt (TrEMBL) Submitted Name of Target Chain 41 UniProt (TrEMBL) Entry Name of Target Chain 41 UniProt (TrEMBL) Primary ID of Target Chain 41 UniProt (TrEMBL) Secondary ID(s) of Target Chain 41 UniProt (TrEMBL) Alternative ID(s) of Target Chain 41 BindingDB Target Chain Sequence 42 PDB ID(s) of Target Chain 42 UniProt (SwissProt) Recommended Name of Target Chain 42 UniProt (SwissProt) Entry Name of Target Chain 42 UniProt (SwissProt) Primary ID of Target Chain 42 UniProt (SwissProt) Secondary ID(s) of Target Chain 42 UniProt (SwissProt) Alternative ID(s) of Target Chain 42 UniProt (TrEMBL) Submitted Name of Target Chain 42 UniProt (TrEMBL) Entry Name of Target Chain 42 UniProt (TrEMBL) Primary ID of Target Chain 42 UniProt (TrEMBL) Secondary ID(s) of Target Chain 42 UniProt (TrEMBL) Alternative ID(s) of Target Chain 42 BindingDB Target Chain Sequence 43 PDB ID(s) of Target Chain 43 UniProt (SwissProt) Recommended Name of Target Chain 43 UniProt (SwissProt) Entry Name of Target Chain 43 UniProt (SwissProt) Primary ID of Target Chain 43 UniProt (SwissProt) Secondary ID(s) of Target Chain 43 UniProt (SwissProt) Alternative ID(s) of Target Chain 43 UniProt (TrEMBL) Submitted Name of Target Chain 43 UniProt (TrEMBL) Entry Name of Target Chain 43 UniProt (TrEMBL) Primary ID of Target Chain 43 UniProt (TrEMBL) Secondary ID(s) of Target Chain 43 UniProt (TrEMBL) Alternative ID(s) of Target Chain 43 BindingDB Target Chain Sequence 44 PDB ID(s) of Target Chain 44 UniProt (SwissProt) Recommended Name of Target Chain 44 UniProt (SwissProt) Entry Name of Target Chain 44 UniProt (SwissProt) Primary ID of Target Chain 44 UniProt (SwissProt) Secondary ID(s) of Target Chain 44 UniProt (SwissProt) Alternative ID(s) of Target Chain 44 UniProt (TrEMBL) Submitted Name of Target Chain 44 UniProt (TrEMBL) Entry Name of Target Chain 44 UniProt (TrEMBL) Primary ID of Target Chain 44 UniProt (TrEMBL) Secondary ID(s) of Target Chain 44 UniProt (TrEMBL) Alternative ID(s) of Target Chain 44 BindingDB Target Chain Sequence 45 PDB ID(s) of Target Chain 45 UniProt (SwissProt) Recommended Name of Target Chain 45 UniProt (SwissProt) Entry Name of Target Chain 45 UniProt (SwissProt) Primary ID of Target Chain 45 UniProt (SwissProt) Secondary ID(s) of Target Chain 45 UniProt (SwissProt) Alternative ID(s) of Target Chain 45 UniProt (TrEMBL) Submitted Name of Target Chain 45 UniProt (TrEMBL) Entry Name of Target Chain 45 UniProt (TrEMBL) Primary ID of Target Chain 45 UniProt (TrEMBL) Secondary ID(s) of Target Chain 45 UniProt (TrEMBL) Alternative ID(s) of Target Chain 45 BindingDB Target Chain Sequence 46 PDB ID(s) of Target Chain 46 UniProt (SwissProt) Recommended Name of Target Chain 46 UniProt (SwissProt) Entry Name of Target Chain 46 UniProt (SwissProt) Primary ID of Target Chain 46 UniProt (SwissProt) Secondary ID(s) of Target Chain 46 UniProt (SwissProt) Alternative ID(s) of Target Chain 46 UniProt (TrEMBL) Submitted Name of Target Chain 46 UniProt (TrEMBL) Entry Name of Target Chain 46 UniProt (TrEMBL) Primary ID of Target Chain 46 UniProt (TrEMBL) Secondary ID(s) of Target Chain 46 UniProt (TrEMBL) Alternative ID(s) of Target Chain 46 BindingDB Target Chain Sequence 47 PDB ID(s) of Target Chain 47 UniProt (SwissProt) Recommended Name of Target Chain 47 UniProt (SwissProt) Entry Name of Target Chain 47 UniProt (SwissProt) Primary ID of Target Chain 47 UniProt (SwissProt) Secondary ID(s) of Target Chain 47 UniProt (SwissProt) Alternative ID(s) of Target Chain 47 UniProt (TrEMBL) Submitted Name of Target Chain 47 UniProt (TrEMBL) Entry Name of Target Chain 47 UniProt (TrEMBL) Primary ID of Target Chain 47 UniProt (TrEMBL) Secondary ID(s) of Target Chain 47 UniProt (TrEMBL) Alternative ID(s) of Target Chain 47 BindingDB Target Chain Sequence 48 PDB ID(s) of Target Chain 48 UniProt (SwissProt) Recommended Name of Target Chain 48 UniProt (SwissProt) Entry Name of Target Chain 48 UniProt (SwissProt) Primary ID of Target Chain 48 UniProt (SwissProt) Secondary ID(s) of Target Chain 48 UniProt (SwissProt) Alternative ID(s) of Target Chain 48 UniProt (TrEMBL) Submitted Name of Target Chain 48 UniProt (TrEMBL) Entry Name of Target Chain 48 UniProt (TrEMBL) Primary ID of Target Chain 48 UniProt (TrEMBL) Secondary ID(s) of Target Chain 48 UniProt (TrEMBL) Alternative ID(s) of Target Chain 48 BindingDB Target Chain Sequence 49 PDB ID(s) of Target Chain 49 UniProt (SwissProt) Recommended Name of Target Chain 49 UniProt (SwissProt) Entry Name of Target Chain 49 UniProt (SwissProt) Primary ID of Target Chain 49 UniProt (SwissProt) Secondary ID(s) of Target Chain 49 UniProt (SwissProt) Alternative ID(s) of Target Chain 49 UniProt (TrEMBL) Submitted Name of Target Chain 49 UniProt (TrEMBL) Entry Name of Target Chain 49 UniProt (TrEMBL) Primary ID of Target Chain 49 UniProt (TrEMBL) Secondary ID(s) of Target Chain 49 UniProt (TrEMBL) Alternative ID(s) of Target Chain 49 BindingDB Target Chain Sequence 50 PDB ID(s) of Target Chain 50 UniProt (SwissProt) Recommended Name of Target Chain 50 UniProt (SwissProt) Entry Name of Target Chain 50 UniProt (SwissProt) Primary ID of Target Chain 50 UniProt (SwissProt) Secondary ID(s) of Target Chain 50 UniProt (SwissProt) Alternative ID(s) of Target Chain 50 UniProt (TrEMBL) Submitted Name of Target Chain 50 UniProt (TrEMBL) Entry Name of Target Chain 50 UniProt (TrEMBL) Primary ID of Target Chain 50 UniProt (TrEMBL) Secondary ID(s) of Target Chain 50 UniProt (TrEMBL) Alternative ID(s) of Target Chain 50 191079 COc1ccc(-c2cc3cn[nH]c3n(-c3ccc4nn(C)cc4c3)c2=O)cc1 InChI=1S/C21H17N5O2/c1-25-12-15-9-16(5-8-19(15)24-25)26-20-14(11-22-23-20)10-18(21(26)27)13-3-6-17(28-2)7-4-13/h3-12H,1-2H3,(H,22,23) CHPUENCZVRQVEL-UHFFFAOYSA-N 276655 US20260014125, Compound 1 S-adenosylmethionine synthase isoform type-2 Homo sapiens >10000 US Patent 10.7270/Q2H99B1C US20260014125 LI, Z; YANG, J; TU, W; YU, B; ZHANG, Y; LI, L 1/15/2026 5/28/2026 Haihe Biopharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=276655 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=276655&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search 130309862 378158321 1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,30GH,30GD,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM S-adenosylmethionine synthase isoform type-2 METK2_HUMAN P31153 A8K511 B4DN45 D6W5L1 Q53SP5 191080 CCOc1c(-c2ccc(OC)cc2)c(=O)n(-c2ccc3ncn(C)c3c2)c2[nH]ncc12 InChI=1S/C23H21N5O3/c1-4-31-21-17-12-25-26-22(17)28(15-7-10-18-19(11-15)27(2)13-24-18)23(29)20(21)14-5-8-16(30-3)9-6-14/h5-13H,4H2,1-3H3,(H,25,26) XSJWPFUKRCGMGC-UHFFFAOYSA-N 276669 US20260014125, Compound 15 S-adenosylmethionine synthase isoform type-2 Homo sapiens 15.3 US Patent 10.7270/Q2H99B1C US20260014125 LI, Z; YANG, J; TU, W; YU, B; ZHANG, Y; LI, L 1/15/2026 5/28/2026 Haihe Biopharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=276669 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=276669&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search 130309875 378158334 1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,30GH,30GD,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM S-adenosylmethionine synthase isoform type-2 METK2_HUMAN P31153 A8K511 B4DN45 D6W5L1 Q53SP5 191081 Cn5cc4cc(n3c(=O)c(c1ccc(Cl)cc1)c(OCC(F)(F)F)c2cn[nH]c23)ccc4n5 InChI=1S/C22H15ClF3N5O2/c1-30-10-13-8-15(6-7-17(13)29-30)31-20-16(9-27-28-20)19(33-11-22(24,25)26)18(21(31)32)12-2-4-14(23)5-3-12/h2-10H,11H2,1H3,(H,27,28) CFRYZDRZIYWLRA-UHFFFAOYSA-N 276670 US20260014125, Compound 28 S-adenosylmethionine synthase isoform type-2 Homo sapiens 15.0 US Patent 10.7270/Q2H99B1C US20260014125 LI, Z; YANG, J; TU, W; YU, B; ZHANG, Y; LI, L 1/15/2026 5/28/2026 Haihe Biopharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=276670 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=276670&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search 130309876 378158335 1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,30GH,30GD,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM S-adenosylmethionine synthase isoform type-2 METK2_HUMAN P31153 A8K511 B4DN45 D6W5L1 Q53SP5 191082 CCOc1c(-c2ccc(OC(F)F)cc2)c(=O)n(-c2ccc3nn(C)cc3n2)c2[nH]ncc12 InChI=1S/C22H18F2N6O3/c1-3-32-19-14-10-25-27-20(14)30(17-9-8-15-16(26-17)11-29(2)28-15)21(31)18(19)12-4-6-13(7-5-12)33-22(23)24/h4-11,22H,3H2,1-2H3,(H,25,27) KOTCUSQPVPAFPP-UHFFFAOYSA-N 276671 US20260014125, Compound 41 S-adenosylmethionine synthase isoform type-2 Homo sapiens 12.7 US Patent 10.7270/Q2H99B1C US20260014125 LI, Z; YANG, J; TU, W; YU, B; ZHANG, Y; LI, L 1/15/2026 5/28/2026 Haihe Biopharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=276671 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=276671&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search 130309877 378158336 1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,30GH,30GD,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM S-adenosylmethionine synthase isoform type-2 METK2_HUMAN P31153 A8K511 B4DN45 D6W5L1 Q53SP5 191083 CCNc1c(-c2ccc(OC)cc2)c(=O)n(-c2ccc3nn(C)cc3c2)c2[nH]ncc12 InChI=1S/C23H22N6O2/c1-4-24-21-18-12-25-26-22(18)29(16-7-10-19-15(11-16)13-28(2)27-19)23(30)20(21)14-5-8-17(31-3)9-6-14/h5-13,24H,4H2,1-3H3,(H,25,26) DQGQIKFIRMGYAV-UHFFFAOYSA-N 276672 US20260014125, Compound 2 S-adenosylmethionine synthase isoform type-2 Homo sapiens 17.5 US Patent 10.7270/Q2H99B1C US20260014125 LI, Z; YANG, J; TU, W; YU, B; ZHANG, Y; LI, L 1/15/2026 5/28/2026 Haihe Biopharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=276672 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=276672&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search 130309879 378158337 1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,30GH,30GD,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM S-adenosylmethionine synthase isoform type-2 METK2_HUMAN P31153 A8K511 B4DN45 D6W5L1 Q53SP5 191084 CCNc1c(-c2ccc(Cl)cc2)c(=O)n(-c2ccc3c(c2)ncn3C)c2[nH]ncc12 InChI=1S/C22H19ClN6O/c1-3-24-20-16-11-26-27-21(16)29(15-8-9-18-17(10-15)25-12-28(18)2)22(30)19(20)13-4-6-14(23)7-5-13/h4-12,24H,3H2,1-2H3,(H,26,27) KKXOKLNUMVXLSF-UHFFFAOYSA-N 276673 US20260014125, Compound 16 S-adenosylmethionine synthase isoform type-2 Homo sapiens >10000 US Patent 10.7270/Q2H99B1C US20260014125 LI, Z; YANG, J; TU, W; YU, B; ZHANG, Y; LI, L 1/15/2026 5/28/2026 Haihe Biopharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=276673 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=276673&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search 130309878 378158338 1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,30GH,30GD,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM S-adenosylmethionine synthase isoform type-2 METK2_HUMAN P31153 A8K511 B4DN45 D6W5L1 Q53SP5 191085 COc5ccc(c4c(OCC(F)(F)F)c1cn[nH]c1n(c3ccc2nn(C)cc2c3)c4=O)cn5 InChI=1S/C22H17F3N6O3/c1-30-10-13-7-14(4-5-16(13)29-30)31-20-15(9-27-28-20)19(34-11-22(23,24)25)18(21(31)32)12-3-6-17(33-2)26-8-12/h3-10H,11H2,1-2H3,(H,27,28) KFKDSOJKCQYOFZ-UHFFFAOYSA-N 276674 US20260014125, Compound 29 S-adenosylmethionine synthase isoform type-2 Homo sapiens 12.3 US Patent 10.7270/Q2H99B1C US20260014125 LI, Z; YANG, J; TU, W; YU, B; ZHANG, Y; LI, L 1/15/2026 5/28/2026 Haihe Biopharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=276674 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=276674&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search 130309880 378158339 1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,30GH,30GD,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM S-adenosylmethionine synthase isoform type-2 METK2_HUMAN P31153 A8K511 B4DN45 D6W5L1 Q53SP5 191086 CCOc1c(-c2ccc(OC(F)F)cc2)c(=O)n(-c2ccc3nn(C)cc3c2)c2nn(C)cc12 InChI=1S/C24H21F2N5O3/c1-4-33-21-18-13-30(3)28-22(18)31(16-7-10-19-15(11-16)12-29(2)27-19)23(32)20(21)14-5-8-17(9-6-14)34-24(25)26/h5-13,24H,4H2,1-3H3 WZCUYENXACBCCD-UHFFFAOYSA-N 276675 US20260014125, Compound 45 S-adenosylmethionine synthase isoform type-2 Homo sapiens 10.5 US Patent 10.7270/Q2H99B1C US20260014125 LI, Z; YANG, J; TU, W; YU, B; ZHANG, Y; LI, L 1/15/2026 5/28/2026 Haihe Biopharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=276675 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=276675&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search 130309881 378158340 1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,30GH,30GD,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM S-adenosylmethionine synthase isoform type-2 METK2_HUMAN P31153 A8K511 B4DN45 D6W5L1 Q53SP5 191087 CCOc1c(-c2ccc(OC)cc2)c(=O)n(-c2ccc3nn(C)cc3c2)c2[nH]ncc12 InChI=1S/C23H21N5O3/c1-4-31-21-18-12-24-25-22(18)28(16-7-10-19-15(11-16)13-27(2)26-19)23(29)20(21)14-5-8-17(30-3)9-6-14/h5-13H,4H2,1-3H3,(H,24,25) AUUIJHIWEVZFHM-UHFFFAOYSA-N 276676 US20260014125, Compound 3 S-adenosylmethionine synthase isoform type-2 Homo sapiens 19.4 US Patent 10.7270/Q2H99B1C US20260014125 LI, Z; YANG, J; TU, W; YU, B; ZHANG, Y; LI, L 1/15/2026 5/28/2026 Haihe Biopharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=276676 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=276676&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search 130309882 378158341 1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,30GH,30GD,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM S-adenosylmethionine synthase isoform type-2 METK2_HUMAN P31153 A8K511 B4DN45 D6W5L1 Q53SP5 191088 CCOc1c(-c2ccc(F)cc2)c(=O)n(-c2ccc3nn(C)cc3c2)c2[nH]ncc12 InChI=1S/C22H18FN5O2/c1-3-30-20-17-11-24-25-21(17)28(16-8-9-18-14(10-16)12-27(2)26-18)22(29)19(20)13-4-6-15(23)7-5-13/h4-12H,3H2,1-2H3,(H,24,25) HYIJXSSCQUCOBW-UHFFFAOYSA-N 276677 US20260014125, Compound 17 S-adenosylmethionine synthase isoform type-2 Homo sapiens 13.9 US Patent 10.7270/Q2H99B1C US20260014125 LI, Z; YANG, J; TU, W; YU, B; ZHANG, Y; LI, L 1/15/2026 5/28/2026 Haihe Biopharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=276677 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=276677&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search 130309883 378158342 1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,30GH,30GD,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM S-adenosylmethionine synthase isoform type-2 METK2_HUMAN P31153 A8K511 B4DN45 D6W5L1 Q53SP5 191089 CCOc1c(-c2ccc(OC(F)F)cc2)c(=O)n(-c2ccc3nn(C)cc3c2)c2c1cnn2C InChI=1S/C24H21F2N5O3/c1-4-33-21-18-12-27-30(3)22(18)31(16-7-10-19-15(11-16)13-29(2)28-19)23(32)20(21)14-5-8-17(9-6-14)34-24(25)26/h5-13,24H,4H2,1-3H3 UKPKPFAPPQPQQH-UHFFFAOYSA-N 276678 US20260014125, Compound 31 S-adenosylmethionine synthase isoform type-2 Homo sapiens 120 US Patent 10.7270/Q2H99B1C US20260014125 LI, Z; YANG, J; TU, W; YU, B; ZHANG, Y; LI, L 1/15/2026 5/28/2026 Haihe Biopharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=276678 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=276678&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search 130309884 378158343 1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,30GH,30GD,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM S-adenosylmethionine synthase isoform type-2 METK2_HUMAN P31153 A8K511 B4DN45 D6W5L1 Q53SP5 191090 CCOc1c(-c2ccc(C(F)(F)F)nc2)c(=O)n(-c2ccc3nn(C)cc3c2)c2[nH]ncc12 InChI=1S/C22H17F3N6O2/c1-3-33-19-15-10-27-28-20(15)31(14-5-6-16-13(8-14)11-30(2)29-16)21(32)18(19)12-4-7-17(26-9-12)22(23,24)25/h4-11H,3H2,1-2H3,(H,27,28) NEMNPOYHXLZBKC-UHFFFAOYSA-N 276679 US20260014125, Compound 46 S-adenosylmethionine synthase isoform type-2 Homo sapiens 15.3 US Patent 10.7270/Q2H99B1C US20260014125 LI, Z; YANG, J; TU, W; YU, B; ZHANG, Y; LI, L 1/15/2026 5/28/2026 Haihe Biopharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=276679 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=276679&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search 130309885 378158344 1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,30GH,30GD,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM S-adenosylmethionine synthase isoform type-2 METK2_HUMAN P31153 A8K511 B4DN45 D6W5L1 Q53SP5 191091 CNc1c(-c2ccc(OC)cc2)c(=O)n(-c2ccc3nn(C)cc3c2)c2[nH]ncc12 InChI=1S/C22H20N6O2/c1-23-20-17-11-24-25-21(17)28(15-6-9-18-14(10-15)12-27(2)26-18)22(29)19(20)13-4-7-16(30-3)8-5-13/h4-12,23H,1-3H3,(H,24,25) QLRATRUKRJCANR-UHFFFAOYSA-N 276680 US20260014125, Compound 4 S-adenosylmethionine synthase isoform type-2 Homo sapiens 62.0 US Patent 10.7270/Q2H99B1C US20260014125 LI, Z; YANG, J; TU, W; YU, B; ZHANG, Y; LI, L 1/15/2026 5/28/2026 Haihe Biopharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=276680 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=276680&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search 130309886 378158345 1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,30GH,30GD,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM S-adenosylmethionine synthase isoform type-2 METK2_HUMAN P31153 A8K511 B4DN45 D6W5L1 Q53SP5 191092 CCOc1c(-c2cccc(OC)c2)c(=O)n(-c2ccc3nn(C)cc3c2)c2[nH]ncc12 InChI=1S/C23H21N5O3/c1-4-31-21-18-12-24-25-22(18)28(16-8-9-19-15(10-16)13-27(2)26-19)23(29)20(21)14-6-5-7-17(11-14)30-3/h5-13H,4H2,1-3H3,(H,24,25) FPIMYADHDMKDRJ-UHFFFAOYSA-N 276681 US20260014125, Compound 18 S-adenosylmethionine synthase isoform type-2 Homo sapiens 22.9 US Patent 10.7270/Q2H99B1C US20260014125 LI, Z; YANG, J; TU, W; YU, B; ZHANG, Y; LI, L 1/15/2026 5/28/2026 Haihe Biopharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=276681 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=276681&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search 130309889 378158346 1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,30GH,30GD,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM S-adenosylmethionine synthase isoform type-2 METK2_HUMAN P31153 A8K511 B4DN45 D6W5L1 Q53SP5 191093 Cn5cc4cc(n3c(=O)c(c1ccc(Cl)cc1)c(OCC(F)(F)F)c2cn[nH]c23)ccc4n5 InChI=1S/C22H15ClF3N5O2/c1-30-10-13-8-15(6-7-17(13)29-30)31-20-16(9-27-28-20)19(33-11-22(24,25)26)18(21(31)32)12-2-4-14(23)5-3-12/h2-10H,11H2,1H3,(H,27,28) CFRYZDRZIYWLRA-UHFFFAOYSA-N 276670 US20260014125, Compound 28 S-adenosylmethionine synthase isoform type-2 Homo sapiens 15.0 US Patent 10.7270/Q2H99B1C US20260014125 LI, Z; YANG, J; TU, W; YU, B; ZHANG, Y; LI, L 1/15/2026 5/28/2026 Haihe Biopharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=276670 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=276670&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search 130309876 378158335 1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,30GH,30GD,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM S-adenosylmethionine synthase isoform type-2 METK2_HUMAN P31153 A8K511 B4DN45 D6W5L1 Q53SP5 191094 CCOc1c(-c2ccc(C3CC3)nc2)c(=O)n(-c2ccc3nn(C)cc3c2)c2[nH]ncc12 InChI=1S/C24H22N6O2/c1-3-32-22-18-12-26-27-23(18)30(17-7-9-20-16(10-17)13-29(2)28-20)24(31)21(22)15-6-8-19(25-11-15)14-4-5-14/h6-14H,3-5H2,1-2H3,(H,26,27) BIFBZFIBHGNYAW-UHFFFAOYSA-N 276682 US20260014125, Compound 47 S-adenosylmethionine synthase isoform type-2 Homo sapiens 14.8 US Patent 10.7270/Q2H99B1C US20260014125 LI, Z; YANG, J; TU, W; YU, B; ZHANG, Y; LI, L 1/15/2026 5/28/2026 Haihe Biopharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=276682 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=276682&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search 130309887 378158347 1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,30GH,30GD,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM S-adenosylmethionine synthase isoform type-2 METK2_HUMAN P31153 A8K511 B4DN45 D6W5L1 Q53SP5 191095 COc1ccc(-c2c(NCC3CC3)c3cn[nH]c3n(-c3ccc4nn(C)cc4n3)c2=O)cc1 InChI=1S/C24H23N7O2/c1-30-13-19-18(29-30)9-10-20(27-19)31-23-17(12-26-28-23)22(25-11-14-3-4-14)21(24(31)32)15-5-7-16(33-2)8-6-15/h5-10,12-14,25H,3-4,11H2,1-2H3,(H,26,28) KULCBLQHUJZKFK-UHFFFAOYSA-N 276683 US20260014125, Compound 5 S-adenosylmethionine synthase isoform type-2 Homo sapiens 17.7 US Patent 10.7270/Q2H99B1C US20260014125 LI, Z; YANG, J; TU, W; YU, B; ZHANG, Y; LI, L 1/15/2026 5/28/2026 Haihe Biopharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=276683 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=276683&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search 130309888 378158348 1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,30GH,30GD,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM S-adenosylmethionine synthase isoform type-2 METK2_HUMAN P31153 A8K511 B4DN45 D6W5L1 Q53SP5 191096 CCOc4c(c1ccc(OC(F)F)cc1)c(=O)n(c3ccc2nn(CC)cc2c3)c5[nH]ncc45 InChI=1S/C24H21F2N5O3/c1-3-30-13-15-11-16(7-10-19(15)29-30)31-22-18(12-27-28-22)21(33-4-2)20(23(31)32)14-5-8-17(9-6-14)34-24(25)26/h5-13,24H,3-4H2,1-2H3,(H,27,28) AIHBDJMYBDYTJY-UHFFFAOYSA-N 276684 US20260014125, Compound 19 S-adenosylmethionine synthase isoform type-2 Homo sapiens 16.6 US Patent 10.7270/Q2H99B1C US20260014125 LI, Z; YANG, J; TU, W; YU, B; ZHANG, Y; LI, L 1/15/2026 5/28/2026 Haihe Biopharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=276684 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=276684&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search 130309890 378158349 1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,30GH,30GD,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM S-adenosylmethionine synthase isoform type-2 METK2_HUMAN P31153 A8K511 B4DN45 D6W5L1 Q53SP5 191097 Cn1cnc2ccc(-n3c(=O)c(-c4ccc(OC(F)(F)F)cc4)c(OCC4CC4)c4cn[nH]c43)cc21 InChI=1S/C25H20F3N5O3/c1-32-13-29-19-9-6-16(10-20(19)32)33-23-18(11-30-31-23)22(35-12-14-2-3-14)21(24(33)34)15-4-7-17(8-5-15)36-25(26,27)28/h4-11,13-14H,2-3,12H2,1H3,(H,30,31) JHKCYMXPUBKYFN-UHFFFAOYSA-N 276685 US20260014125, Compound 32 S-adenosylmethionine synthase isoform type-2 Homo sapiens 14.6 US Patent 10.7270/Q2H99B1C US20260014125 LI, Z; YANG, J; TU, W; YU, B; ZHANG, Y; LI, L 1/15/2026 5/28/2026 Haihe Biopharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=276685 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=276685&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search 130309891 378158350 1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,30GH,30GD,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM S-adenosylmethionine synthase isoform type-2 METK2_HUMAN P31153 A8K511 B4DN45 D6W5L1 Q53SP5 191098 CCOc1c(-c2ccc(C)nc2)c(=O)n(-c2ccc3nn(C)cc3c2)c2[nH]ncc12 InChI=1S/C22H20N6O2/c1-4-30-20-17-11-24-25-21(17)28(16-7-8-18-15(9-16)12-27(3)26-18)22(29)19(20)14-6-5-13(2)23-10-14/h5-12H,4H2,1-3H3,(H,24,25) XQWFOXGZYWRMAH-UHFFFAOYSA-N 276686 US20260014125, Compound 48 S-adenosylmethionine synthase isoform type-2 Homo sapiens 16.3 US Patent 10.7270/Q2H99B1C US20260014125 LI, Z; YANG, J; TU, W; YU, B; ZHANG, Y; LI, L 1/15/2026 5/28/2026 Haihe Biopharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=276686 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=276686&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search 130309893 378158351 1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,30GH,30GD,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM S-adenosylmethionine synthase isoform type-2 METK2_HUMAN P31153 A8K511 B4DN45 D6W5L1 Q53SP5 191099 CCNc1c(-c2ccc(OC)cc2)c(=O)n(-c2ccc(C#N)cc2)c2[nH]ncc12 InChI=1S/C22H19N5O2/c1-3-24-20-18-13-25-26-21(18)27(16-8-4-14(12-23)5-9-16)22(28)19(20)15-6-10-17(29-2)11-7-15/h4-11,13,24H,3H2,1-2H3,(H,25,26) KDBZTXALIPGTPU-UHFFFAOYSA-N 276687 US20260014125, Compound 6 S-adenosylmethionine synthase isoform type-2 Homo sapiens 708 US Patent 10.7270/Q2H99B1C US20260014125 LI, Z; YANG, J; TU, W; YU, B; ZHANG, Y; LI, L 1/15/2026 5/28/2026 Haihe Biopharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=276687 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=276687&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search 130309892 378158352 1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,30GH,30GD,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM S-adenosylmethionine synthase isoform type-2 METK2_HUMAN P31153 A8K511 B4DN45 D6W5L1 Q53SP5 191100 CCOc4c(c1ccc(OC(F)F)cc1)c(=O)n(c3ccc2nn(CCO)cc2c3)c5[nH]ncc45 InChI=1S/C24H21F2N5O4/c1-2-34-21-18-12-27-28-22(18)31(16-5-8-19-15(11-16)13-30(29-19)9-10-32)23(33)20(21)14-3-6-17(7-4-14)35-24(25)26/h3-8,11-13,24,32H,2,9-10H2,1H3,(H,27,28) NSOFKZVPAODUQE-UHFFFAOYSA-N 276688 US20260014125, Compound 20 S-adenosylmethionine synthase isoform type-2 Homo sapiens 9.80 US Patent 10.7270/Q2H99B1C US20260014125 LI, Z; YANG, J; TU, W; YU, B; ZHANG, Y; LI, L 1/15/2026 5/28/2026 Haihe Biopharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=276688 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=276688&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search 130309894 378158353 1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,30GH,30GD,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM S-adenosylmethionine synthase isoform type-2 METK2_HUMAN P31153 A8K511 B4DN45 D6W5L1 Q53SP5 191101 CCOc1c(-c2ccc(Cl)cc2)c(=O)n(-c2ccc3ncn(C)c3c2)c2[nH]ncc12 InChI=1S/C22H18ClN5O2/c1-3-30-20-16-11-25-26-21(16)28(15-8-9-17-18(10-15)27(2)12-24-17)22(29)19(20)13-4-6-14(23)7-5-13/h4-12H,3H2,1-2H3,(H,25,26) SDTYURAOFUFDID-UHFFFAOYSA-N 276689 US20260014125, Compound 33 S-adenosylmethionine synthase isoform type-2 Homo sapiens 14.9 US Patent 10.7270/Q2H99B1C US20260014125 LI, Z; YANG, J; TU, W; YU, B; ZHANG, Y; LI, L 1/15/2026 5/28/2026 Haihe Biopharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=276689 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=276689&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search 130309895 378158354 1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,30GH,30GD,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM S-adenosylmethionine synthase isoform type-2 METK2_HUMAN P31153 A8K511 B4DN45 D6W5L1 Q53SP5 191102 Cn5cc4cc(n3c(=O)c(c1ccc(F)cc1)c(OCC(F)(F)F)c2cn[nH]c23)ccc4n5 InChI=1S/C22H15F4N5O2/c1-30-10-13-8-15(6-7-17(13)29-30)31-20-16(9-27-28-20)19(33-11-22(24,25)26)18(21(31)32)12-2-4-14(23)5-3-12/h2-10H,11H2,1H3,(H,27,28) BUWMTVUUMBLIHR-UHFFFAOYSA-N 276690 US20260014125, Compound 49 S-adenosylmethionine synthase isoform type-2 Homo sapiens 17.9 US Patent 10.7270/Q2H99B1C US20260014125 LI, Z; YANG, J; TU, W; YU, B; ZHANG, Y; LI, L 1/15/2026 5/28/2026 Haihe Biopharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=276690 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=276690&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search 130309896 378158355 1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,30GH,30GD,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM S-adenosylmethionine synthase isoform type-2 METK2_HUMAN P31153 A8K511 B4DN45 D6W5L1 Q53SP5 191103 CCNc1c(-c2ccc(OC)cc2)c(=O)n(C2=CN(C)C(OC)C=C2)c2[nH]ncc12 InChI=1S/C22H25N5O3/c1-5-23-20-17-12-24-25-21(17)27(15-8-11-18(30-4)26(2)13-15)22(28)19(20)14-6-9-16(29-3)10-7-14/h6-13,18,23H,5H2,1-4H3,(H,24,25) UNFQRAKKJWAHSY-UHFFFAOYSA-N 276691 US20260014125, Compound 7 S-adenosylmethionine synthase isoform type-2 Homo sapiens 35.3 US Patent 10.7270/Q2H99B1C US20260014125 LI, Z; YANG, J; TU, W; YU, B; ZHANG, Y; LI, L 1/15/2026 5/28/2026 Haihe Biopharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=276691 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=276691&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search 130309897 378158356 1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,30GH,30GD,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM S-adenosylmethionine synthase isoform type-2 METK2_HUMAN P31153 A8K511 B4DN45 D6W5L1 Q53SP5 191104 CCOc4c(c1ccc(OC(F)F)cc1)c(=O)n(c3ccc2nn(CCOC)cc2c3)c5[nH]ncc45 InChI=1S/C25H23F2N5O4/c1-3-35-22-19-13-28-29-23(19)32(17-6-9-20-16(12-17)14-31(30-20)10-11-34-2)24(33)21(22)15-4-7-18(8-5-15)36-25(26)27/h4-9,12-14,25H,3,10-11H2,1-2H3,(H,28,29) MABCOJLEDVYERC-UHFFFAOYSA-N 276692 US20260014125, Compound 21 S-adenosylmethionine synthase isoform type-2 Homo sapiens 8.30 US Patent 10.7270/Q2H99B1C US20260014125 LI, Z; YANG, J; TU, W; YU, B; ZHANG, Y; LI, L 1/15/2026 5/28/2026 Haihe Biopharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=276692 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=276692&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search 130309898 378158357 1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,30GH,30GD,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM S-adenosylmethionine synthase isoform type-2 METK2_HUMAN P31153 A8K511 B4DN45 D6W5L1 Q53SP5 191105 CCOc1c(-c2ccc(Cl)cc2)c(=O)n(-c2ccc3ncn(CC)c3c2)c2[nH]ncc12 InChI=1S/C23H20ClN5O2/c1-3-28-13-25-18-10-9-16(11-19(18)28)29-22-17(12-26-27-22)21(31-4-2)20(23(29)30)14-5-7-15(24)8-6-14/h5-13H,3-4H2,1-2H3,(H,26,27) ZMOZARMUPBESBH-UHFFFAOYSA-N 276693 US20260014125, Compound 34 S-adenosylmethionine synthase isoform type-2 Homo sapiens 22.1 US Patent 10.7270/Q2H99B1C US20260014125 LI, Z; YANG, J; TU, W; YU, B; ZHANG, Y; LI, L 1/15/2026 5/28/2026 Haihe Biopharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=276693 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=276693&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search 130309899 378158358 1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,30GH,30GD,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM S-adenosylmethionine synthase isoform type-2 METK2_HUMAN P31153 A8K511 B4DN45 D6W5L1 Q53SP5 191106 Cn1cc2cc(-n3c(=O)c(-c4ccc(Cl)cc4)c(OCC4CC4)c4cn[nH]c43)ccc2n1 InChI=1S/C24H20ClN5O2/c1-29-12-16-10-18(8-9-20(16)28-29)30-23-19(11-26-27-23)22(32-13-14-2-3-14)21(24(30)31)15-4-6-17(25)7-5-15/h4-12,14H,2-3,13H2,1H3,(H,26,27) IKNCXDUFJSPRGJ-UHFFFAOYSA-N 276694 US20260014125, Compound 50 S-adenosylmethionine synthase isoform type-2 Homo sapiens 13.6 US Patent 10.7270/Q2H99B1C US20260014125 LI, Z; YANG, J; TU, W; YU, B; ZHANG, Y; LI, L 1/15/2026 5/28/2026 Haihe Biopharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=276694 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=276694&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search 130309901 378158359 1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,30GH,30GD,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM S-adenosylmethionine synthase isoform type-2 METK2_HUMAN P31153 A8K511 B4DN45 D6W5L1 Q53SP5 191107 CCNc1c(-c2ccc(OC(F)F)cc2)c(=O)n(-c2ccc3nn(C)cc3c2)c2[nH]ncc12 InChI=1S/C23H20F2N6O2/c1-3-26-20-17-11-27-28-21(17)31(15-6-9-18-14(10-15)12-30(2)29-18)22(32)19(20)13-4-7-16(8-5-13)33-23(24)25/h4-12,23,26H,3H2,1-2H3,(H,27,28) WAHLZBOZLQZOHG-UHFFFAOYSA-N 276695 US20260014125, Compound 9 S-adenosylmethionine synthase isoform type-2 Homo sapiens 15.3 US Patent 10.7270/Q2H99B1C US20260014125 LI, Z; YANG, J; TU, W; YU, B; ZHANG, Y; LI, L 1/15/2026 5/28/2026 Haihe Biopharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=276695 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=276695&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search 130302462 378158360 1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,30GH,30GD,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM S-adenosylmethionine synthase isoform type-2 METK2_HUMAN P31153 A8K511 B4DN45 D6W5L1 Q53SP5 191108 CCOc4c(c1ccc(OC(F)F)cc1)c(=O)n(c3ccc2ncn(C)c2c3)c5[nH]ncc45 InChI=1S/C23H19F2N5O3/c1-3-32-20-16-11-27-28-21(16)30(14-6-9-17-18(10-14)29(2)12-26-17)22(31)19(20)13-4-7-15(8-5-13)33-23(24)25/h4-12,23H,3H2,1-2H3,(H,27,28) IJJYZPQRNZVZEQ-UHFFFAOYSA-N 276696 US20260014125, Compound 22 S-adenosylmethionine synthase isoform type-2 Homo sapiens 16.0 US Patent 10.7270/Q2H99B1C US20260014125 LI, Z; YANG, J; TU, W; YU, B; ZHANG, Y; LI, L 1/15/2026 5/28/2026 Haihe Biopharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=276696 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=276696&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search 130309900 378158361 1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,30GH,30GD,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM S-adenosylmethionine synthase isoform type-2 METK2_HUMAN P31153 A8K511 B4DN45 D6W5L1 Q53SP5 191109 CCOc1c(-c2ccc(Cl)cc2)c(=O)n(-c2ccc3ncn(C4CNC4)c3c2)c2[nH]ncc12 InChI=1S/C24H21ClN6O2/c1-2-33-22-18-12-28-29-23(18)31(24(32)21(22)14-3-5-15(25)6-4-14)16-7-8-19-20(9-16)30(13-27-19)17-10-26-11-17/h3-9,12-13,17,26H,2,10-11H2,1H3,(H,28,29) CEMJYKRIYGHJTO-UHFFFAOYSA-N 276697 US20260014125, Compound 35 S-adenosylmethionine synthase isoform type-2 Homo sapiens 60.8 US Patent 10.7270/Q2H99B1C US20260014125 LI, Z; YANG, J; TU, W; YU, B; ZHANG, Y; LI, L 1/15/2026 5/28/2026 Haihe Biopharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=276697 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=276697&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search 130309914 378158362 1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,30GH,30GD,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM S-adenosylmethionine synthase isoform type-2 METK2_HUMAN P31153 A8K511 B4DN45 D6W5L1 Q53SP5 191110 Cn1cc2cc(-n3c(=O)c(-c4ccc(F)cc4)c(OCC4CC4)c4cn[nH]c43)ccc2n1 InChI=1S/C24H20FN5O2/c1-29-12-16-10-18(8-9-20(16)28-29)30-23-19(11-26-27-23)22(32-13-14-2-3-14)21(24(30)31)15-4-6-17(25)7-5-15/h4-12,14H,2-3,13H2,1H3,(H,26,27) YUJFVYDIDLEQRR-UHFFFAOYSA-N 276698 US20260014125, Compound 51 S-adenosylmethionine synthase isoform type-2 Homo sapiens 15.7 US Patent 10.7270/Q2H99B1C US20260014125 LI, Z; YANG, J; TU, W; YU, B; ZHANG, Y; LI, L 1/15/2026 5/28/2026 Haihe Biopharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=276698 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=276698&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search 130309907 378158363 1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,30GH,30GD,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM S-adenosylmethionine synthase isoform type-2 METK2_HUMAN P31153 A8K511 B4DN45 D6W5L1 Q53SP5 191111 CCNc1c(-c2ccc(OC)cc2)c(=O)n(-c2ccc(OC)cc2)c2[nH]ncc12 InChI=1S/C22H22N4O3/c1-4-23-20-18-13-24-25-21(18)26(15-7-11-17(29-3)12-8-15)22(27)19(20)14-5-9-16(28-2)10-6-14/h5-13,23H,4H2,1-3H3,(H,24,25) JTGIXDPCVNQNGC-UHFFFAOYSA-N 276699 US20260014125, Compound 10 S-adenosylmethionine synthase isoform type-2 Homo sapiens 20.6 US Patent 10.7270/Q2H99B1C US20260014125 LI, Z; YANG, J; TU, W; YU, B; ZHANG, Y; LI, L 1/15/2026 5/28/2026 Haihe Biopharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=276699 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=276699&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search 130309902 378158364 1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,30GH,30GD,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM S-adenosylmethionine synthase isoform type-2 METK2_HUMAN P31153 A8K511 B4DN45 D6W5L1 Q53SP5 191112 CCOc4c(c1ccc(OC(F)F)cc1)c(=O)n(c3ccn2nccc2c3)c5[nH]ncc45 InChI=1S/C22H17F2N5O3/c1-2-31-19-17-12-25-27-20(17)29(15-8-10-28-14(11-15)7-9-26-28)21(30)18(19)13-3-5-16(6-4-13)32-22(23)24/h3-12,22H,2H2,1H3,(H,25,27) ROXBYXVXVJHERT-UHFFFAOYSA-N 276700 US20260014125, Compound 23 S-adenosylmethionine synthase isoform type-2 Homo sapiens 9.80 US Patent 10.7270/Q2H99B1C US20260014125 LI, Z; YANG, J; TU, W; YU, B; ZHANG, Y; LI, L 1/15/2026 5/28/2026 Haihe Biopharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=276700 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=276700&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search 130309903 378158365 1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,30GH,30GD,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM S-adenosylmethionine synthase isoform type-2 METK2_HUMAN P31153 A8K511 B4DN45 D6W5L1 Q53SP5 191113 Cn5cnc4ccc(n3c(=O)c(c1ccc(Cl)cc1)c(OCC(F)(F)F)c2cn[nH]c23)cc45 InChI=1S/C22H15ClF3N5O2/c1-30-11-27-16-7-6-14(8-17(16)30)31-20-15(9-28-29-20)19(33-10-22(24,25)26)18(21(31)32)12-2-4-13(23)5-3-12/h2-9,11H,10H2,1H3,(H,28,29) UFYWKRIVRKSLHT-UHFFFAOYSA-N 276701 US20260014125, Compound 36 S-adenosylmethionine synthase isoform type-2 Homo sapiens 17.0 US Patent 10.7270/Q2H99B1C US20260014125 LI, Z; YANG, J; TU, W; YU, B; ZHANG, Y; LI, L 1/15/2026 5/28/2026 Haihe Biopharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=276701 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=276701&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search 130309908 378158366 1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,30GH,30GD,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM S-adenosylmethionine synthase isoform type-2 METK2_HUMAN P31153 A8K511 B4DN45 D6W5L1 Q53SP5 191114 Cc5ccc(c4c(OCC(F)(F)F)c1cn[nH]c1n(c3ccc2nn(C)cc2c3)c4=O)cn5 InChI=1S/C22H17F3N6O2/c1-12-3-4-13(8-26-12)18-19(33-11-22(23,24)25)16-9-27-28-20(16)31(21(18)32)15-5-6-17-14(7-15)10-30(2)29-17/h3-10H,11H2,1-2H3,(H,27,28) YWCOTQKTAZXFOH-UHFFFAOYSA-N 276702 US20260014125, Compound 52 S-adenosylmethionine synthase isoform type-2 Homo sapiens 17.6 US Patent 10.7270/Q2H99B1C US20260014125 LI, Z; YANG, J; TU, W; YU, B; ZHANG, Y; LI, L 1/15/2026 5/28/2026 Haihe Biopharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=276702 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=276702&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search 130309915 378158367 1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,30GH,30GD,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM S-adenosylmethionine synthase isoform type-2 METK2_HUMAN P31153 A8K511 B4DN45 D6W5L1 Q53SP5 191115 CCNc1c(-c2ccc(Cl)cc2)c(=O)n(-c2ccc3nn(C)cc3c2)c2[nH]ncc12 InChI=1S/C22H19ClN6O/c1-3-24-20-17-11-25-26-21(17)29(16-8-9-18-14(10-16)12-28(2)27-18)22(30)19(20)13-4-6-15(23)7-5-13/h4-12,24H,3H2,1-2H3,(H,25,26) CPLHVQINCWESPZ-UHFFFAOYSA-N 276703 US20260014125, Compound 11 S-adenosylmethionine synthase isoform type-2 Homo sapiens 14.2 US Patent 10.7270/Q2H99B1C US20260014125 LI, Z; YANG, J; TU, W; YU, B; ZHANG, Y; LI, L 1/15/2026 5/28/2026 Haihe Biopharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=276703 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=276703&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search 130309904 378158368 1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,30GH,30GD,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM S-adenosylmethionine synthase isoform type-2 METK2_HUMAN P31153 A8K511 B4DN45 D6W5L1 Q53SP5 191116 CCOc4c(c1ccc(OC(F)F)cc1)c(=O)n(c3ccc2nccn2c3)c5[nH]ncc45 InChI=1S/C22H17F2N5O3/c1-2-31-19-16-11-26-27-20(16)29(14-5-8-17-25-9-10-28(17)12-14)21(30)18(19)13-3-6-15(7-4-13)32-22(23)24/h3-12,22H,2H2,1H3,(H,26,27) VOVVISZZWYUZHY-UHFFFAOYSA-N 276704 US20260014125, Compound 24 S-adenosylmethionine synthase isoform type-2 Homo sapiens 15.9 US Patent 10.7270/Q2H99B1C US20260014125 LI, Z; YANG, J; TU, W; YU, B; ZHANG, Y; LI, L 1/15/2026 5/28/2026 Haihe Biopharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=276704 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=276704&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search 130309909 378158369 1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,30GH,30GD,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM S-adenosylmethionine synthase isoform type-2 METK2_HUMAN P31153 A8K511 B4DN45 D6W5L1 Q53SP5 191117 CCOc1c(-c2ccc(OC(F)F)cc2)c(=O)n(-c2ccc3nn(C4COC4)cc3c2)c2[nH]ncc12 InChI=1S/C25H21F2N5O4/c1-2-35-22-19-10-28-29-23(19)32(24(33)21(22)14-3-6-18(7-4-14)36-25(26)27)16-5-8-20-15(9-16)11-31(30-20)17-12-34-13-17/h3-11,17,25H,2,12-13H2,1H3,(H,28,29) FDPYTHQCBMWPTR-UHFFFAOYSA-N 276705 US20260014125, Compound 37 S-adenosylmethionine synthase isoform type-2 Homo sapiens 11.0 US Patent 10.7270/Q2H99B1C US20260014125 LI, Z; YANG, J; TU, W; YU, B; ZHANG, Y; LI, L 1/15/2026 5/28/2026 Haihe Biopharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=276705 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=276705&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search 130309905 378158370 1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,30GH,30GD,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM S-adenosylmethionine synthase isoform type-2 METK2_HUMAN P31153 A8K511 B4DN45 D6W5L1 Q53SP5 191118 Cn6cc5cc(n4c(=O)c(c2ccc(C1CC1)nc2)c(OCC(F)(F)F)c3cn[nH]c34)ccc5n6 InChI=1S/C24H19F3N6O2/c1-32-11-15-8-16(5-7-19(15)31-32)33-22-17(10-29-30-22)21(35-12-24(25,26)27)20(23(33)34)14-4-6-18(28-9-14)13-2-3-13/h4-11,13H,2-3,12H2,1H3,(H,29,30) HAYXNSLCUXJIET-UHFFFAOYSA-N 276706 US20260014125, Compound 53 S-adenosylmethionine synthase isoform type-2 Homo sapiens 16.0 US Patent 10.7270/Q2H99B1C US20260014125 LI, Z; YANG, J; TU, W; YU, B; ZHANG, Y; LI, L 1/15/2026 5/28/2026 Haihe Biopharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=276706 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=276706&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search 130309916 378158371 1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,30GH,30GD,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM S-adenosylmethionine synthase isoform type-2 METK2_HUMAN P31153 A8K511 B4DN45 D6W5L1 Q53SP5 191119 COc5ccc(c4c(OCC(F)(F)F)c1cn[nH]c1n(c3ccc2nn(C)cc2c3)c4=O)cc5 InChI=1S/C23H21N5O3/c1-4-31-21-18-12-24-25-22(18)28(16-7-10-19-15(11-16)13-27(2)26-19)23(29)20(21)14-5-8-17(30-3)9-6-14/h5-13H,4H2,1-3H3,(H,24,25) AUUIJHIWEVZFHM-UHFFFAOYSA-N 276707 US20260014125, Compound 12 S-adenosylmethionine synthase isoform type-2 Homo sapiens 12.1 US Patent 10.7270/Q2H99B1C US20260014125 LI, Z; YANG, J; TU, W; YU, B; ZHANG, Y; LI, L 1/15/2026 5/28/2026 Haihe Biopharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=276707 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=276707&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search 130309906 378158372 1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,30GH,30GD,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM S-adenosylmethionine synthase isoform type-2 METK2_HUMAN P31153 A8K511 B4DN45 D6W5L1 Q53SP5 191120 CCOc4c(c1ccc(OC(F)F)cc1)c(=O)n(c3ccc2ncnn2c3)c5[nH]ncc45 InChI=1S/C21H16F2N6O3/c1-2-31-18-15-9-25-27-19(15)29(13-5-8-16-24-11-26-28(16)10-13)20(30)17(18)12-3-6-14(7-4-12)32-21(22)23/h3-11,21H,2H2,1H3,(H,25,27) TYVVPKVEINSZKJ-UHFFFAOYSA-N 276708 US20260014125, Compound 25 S-adenosylmethionine synthase isoform type-2 Homo sapiens 14.0 US Patent 10.7270/Q2H99B1C US20260014125 LI, Z; YANG, J; TU, W; YU, B; ZHANG, Y; LI, L 1/15/2026 5/28/2026 Haihe Biopharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=276708 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=276708&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search 130309911 378158373 1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,30GH,30GD,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM S-adenosylmethionine synthase isoform type-2 METK2_HUMAN P31153 A8K511 B4DN45 D6W5L1 Q53SP5 191121 CCOc1c(-c2ccc(OC(F)F)cc2)c(=O)n(-c2ccc3nn(C4CNC4)cc3c2)c2[nH]ncc12 InChI=1S/C25H22F2N6O3/c1-2-35-22-19-12-29-30-23(19)33(24(34)21(22)14-3-6-18(7-4-14)36-25(26)27)16-5-8-20-15(9-16)13-32(31-20)17-10-28-11-17/h3-9,12-13,17,25,28H,2,10-11H2,1H3,(H,29,30) ZMWZWUWJBWUCQB-UHFFFAOYSA-N 276709 US20260014125, Compound 38 S-adenosylmethionine synthase isoform type-2 Homo sapiens 18.6 US Patent 10.7270/Q2H99B1C US20260014125 LI, Z; YANG, J; TU, W; YU, B; ZHANG, Y; LI, L 1/15/2026 5/28/2026 Haihe Biopharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=276709 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=276709&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search 130309912 378158374 1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,30GH,30GD,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM S-adenosylmethionine synthase isoform type-2 METK2_HUMAN P31153 A8K511 B4DN45 D6W5L1 Q53SP5 191122 CCOc1c(-c2ccc(Br)cc2)c(=O)n(-c2ccc3nn(C)cc3c2)c2[nH]ncc12 InChI=1S/C22H18BrN5O2/c1-3-30-20-17-11-24-25-21(17)28(16-8-9-18-14(10-16)12-27(2)26-18)22(29)19(20)13-4-6-15(23)7-5-13/h4-12H,3H2,1-2H3,(H,24,25) MWHSWNGFBPFASD-UHFFFAOYSA-N 276710 US20260014125, Compound 54 S-adenosylmethionine synthase isoform type-2 Homo sapiens 12.9 US Patent 10.7270/Q2H99B1C US20260014125 LI, Z; YANG, J; TU, W; YU, B; ZHANG, Y; LI, L 1/15/2026 5/28/2026 Haihe Biopharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=276710 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=276710&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search 130309927 378158375 1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,30GH,30GD,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM S-adenosylmethionine synthase isoform type-2 METK2_HUMAN P31153 A8K511 B4DN45 D6W5L1 Q53SP5 191123 CCOc1c(-c2ccc(Cl)cc2)c(=O)n(-c2ccc3nn(C)cc3c2)c2[nH]ncc12 InChI=1S/C22H18ClN5O2/c1-3-30-20-17-11-24-25-21(17)28(16-8-9-18-14(10-16)12-27(2)26-18)22(29)19(20)13-4-6-15(23)7-5-13/h4-12H,3H2,1-2H3,(H,24,25) NLZAMUQMLQRAKZ-UHFFFAOYSA-N 276711 US20260014125, Compound 13 S-adenosylmethionine synthase isoform type-2 Homo sapiens 15.1 US Patent 10.7270/Q2H99B1C US20260014125 LI, Z; YANG, J; TU, W; YU, B; ZHANG, Y; LI, L 1/15/2026 5/28/2026 Haihe Biopharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=276711 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=276711&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search 130309913 378158376 1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,30GH,30GD,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM S-adenosylmethionine synthase isoform type-2 METK2_HUMAN P31153 A8K511 B4DN45 D6W5L1 Q53SP5 191124 CCOc1c(-c2ccc(OC(F)F)cc2)c(=O)n(-c2ccc3nncn3c2)c2[nH]ncc12 InChI=1S/C21H16F2N6O3/c1-2-31-18-15-9-24-27-19(15)29(13-5-8-16-26-25-11-28(16)10-13)20(30)17(18)12-3-6-14(7-4-12)32-21(22)23/h3-11,21H,2H2,1H3,(H,24,27) RELQFDIUQVBOJP-UHFFFAOYSA-N 276712 US20260014125, Compound 26 S-adenosylmethionine synthase isoform type-2 Homo sapiens 13.5 US Patent 10.7270/Q2H99B1C US20260014125 LI, Z; YANG, J; TU, W; YU, B; ZHANG, Y; LI, L 1/15/2026 5/28/2026 Haihe Biopharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=276712 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=276712&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search 130309917 378158377 1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,30GH,30GD,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM S-adenosylmethionine synthase isoform type-2 METK2_HUMAN P31153 A8K511 B4DN45 D6W5L1 Q53SP5 191125 Cn1cc2cc(-n3c(=O)c(-c4ccc(OC(F)F)cc4)c(OCC4CC4)c4cn[nH]c43)ccc2n1 InChI=1S/C25H21F2N5O3/c1-31-12-16-10-17(6-9-20(16)30-31)32-23-19(11-28-29-23)22(34-13-14-2-3-14)21(24(32)33)15-4-7-18(8-5-15)35-25(26)27/h4-12,14,25H,2-3,13H2,1H3,(H,28,29) RCDFUDOPTPJMRP-UHFFFAOYSA-N 276713 US20260014125, Compound 39 S-adenosylmethionine synthase isoform type-2 Homo sapiens 15.0 US Patent 10.7270/Q2H99B1C US20260014125 LI, Z; YANG, J; TU, W; YU, B; ZHANG, Y; LI, L 1/15/2026 5/28/2026 Haihe Biopharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=276713 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=276713&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search 130309928 378158378 1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,30GH,30GD,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM S-adenosylmethionine synthase isoform type-2 METK2_HUMAN P31153 A8K511 B4DN45 D6W5L1 Q53SP5 191126 CCOc1c(-c2ccc(Cl)cc2)c(=O)n(-c2ccc3nn(C)cc3c2)c2cn[nH]c12 InChI=1S/C22H18ClN5O2/c1-3-30-21-19(13-4-6-15(23)7-5-13)22(29)28(18-11-24-25-20(18)21)16-8-9-17-14(10-16)12-27(2)26-17/h4-12H,3H2,1-2H3,(H,24,25) LQLGEUQRUKYAFT-UHFFFAOYSA-N 276714 US20260014125, Compound 55 S-adenosylmethionine synthase isoform type-2 Homo sapiens 16.5 US Patent 10.7270/Q2H99B1C US20260014125 LI, Z; YANG, J; TU, W; YU, B; ZHANG, Y; LI, L 1/15/2026 5/28/2026 Haihe Biopharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=276714 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=276714&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search 130309910 378158379 1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,30GH,30GD,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM S-adenosylmethionine synthase isoform type-2 METK2_HUMAN P31153 A8K511 B4DN45 D6W5L1 Q53SP5 191127 CCOc1c(-c2ccc(OC(F)F)cc2)c(=O)n(-c2ccc3nn(C)cc3c2)c2[nH]ncc12 InChI=1S/C23H19F2N5O3/c1-3-32-20-17-11-26-27-21(17)30(15-6-9-18-14(10-15)12-29(2)28-18)22(31)19(20)13-4-7-16(8-5-13)33-23(24)25/h4-12,23H,3H2,1-2H3,(H,26,27) SJQHLHROCGOSEW-UHFFFAOYSA-N 276715 US20260014125, Compound 14 S-adenosylmethionine synthase isoform type-2 Homo sapiens 9.20 US Patent 10.7270/Q2H99B1C US20260014125 LI, Z; YANG, J; TU, W; YU, B; ZHANG, Y; LI, L 1/15/2026 5/28/2026 Haihe Biopharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=276715 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=276715&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search 130309921 378158380 1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,30GH,30GD,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM S-adenosylmethionine synthase isoform type-2 METK2_HUMAN P31153 A8K511 B4DN45 D6W5L1 Q53SP5 191128 Cn5cc4cc(n3c(=O)c(c1ccc(OC(F)F)cc1)c(OCC(F)(F)F)c2cn[nH]c23)ccc4n5 InChI=1S/C23H16F5N5O3/c1-32-10-13-8-14(4-7-17(13)31-32)33-20-16(9-29-30-20)19(35-11-23(26,27)28)18(21(33)34)12-2-5-15(6-3-12)36-22(24)25/h2-10,22H,11H2,1H3,(H,29,30) HPZPEXQEGLFTAV-UHFFFAOYSA-N 276716 US20260014125, Compound 27 S-adenosylmethionine synthase isoform type-2 Homo sapiens 17.1 US Patent 10.7270/Q2H99B1C US20260014125 LI, Z; YANG, J; TU, W; YU, B; ZHANG, Y; LI, L 1/15/2026 5/28/2026 Haihe Biopharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=276716 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=276716&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search 130309922 378158381 1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,30GH,30GD,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM S-adenosylmethionine synthase isoform type-2 METK2_HUMAN P31153 A8K511 B4DN45 D6W5L1 Q53SP5 191129 CCOc1c(-c2ccc(OC(F)F)cc2)c(=O)n(-c2cnc3nn(C)cc3c2)c2[nH]ncc12 InChI=1S/C22H18F2N6O3/c1-3-32-18-16-10-26-27-20(16)30(14-8-13-11-29(2)28-19(13)25-9-14)21(31)17(18)12-4-6-15(7-5-12)33-22(23)24/h4-11,22H,3H2,1-2H3,(H,26,27) SGTGKNPPBBNWDH-UHFFFAOYSA-N 276717 US20260014125, Compound 40 S-adenosylmethionine synthase isoform type-2 Homo sapiens 55.8 US Patent 10.7270/Q2H99B1C US20260014125 LI, Z; YANG, J; TU, W; YU, B; ZHANG, Y; LI, L 1/15/2026 5/28/2026 Haihe Biopharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=276717 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=276717&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search 130309919 378158382 1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,30GH,30GD,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM S-adenosylmethionine synthase isoform type-2 METK2_HUMAN P31153 A8K511 B4DN45 D6W5L1 Q53SP5 191130 CCOc1c(-c2ccc(Cl)cc2)c(=O)n(-c2ccc3nn(C)cc3c2)c2cn(C)nc12 InChI=1S/C23H20ClN5O2/c1-4-31-22-20(14-5-7-16(24)8-6-14)23(30)29(19-13-28(3)26-21(19)22)17-9-10-18-15(11-17)12-27(2)25-18/h5-13H,4H2,1-3H3 CECQDYFXIUSIOC-UHFFFAOYSA-N 276718 US20260014125, Compound 56 S-adenosylmethionine synthase isoform type-2 Homo sapiens 24.4 US Patent 10.7270/Q2H99B1C US20260014125 LI, Z; YANG, J; TU, W; YU, B; ZHANG, Y; LI, L 1/15/2026 5/28/2026 Haihe Biopharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=276718 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=276718&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search 130309918 378158383 1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,30GH,30GD,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM S-adenosylmethionine synthase isoform type-2 METK2_HUMAN P31153 A8K511 B4DN45 D6W5L1 Q53SP5 191131 CCCOc1c(-c2ccc(Cl)nc2)c(=O)n(-c2ccc3nn(C)cc3c2)c2[nH]ncc12 InChI=1S/C22H19ClN6O2/c1-3-8-31-20-16-11-25-26-21(16)29(15-5-6-17-14(9-15)12-28(2)27-17)22(30)19(20)13-4-7-18(23)24-10-13/h4-7,9-12H,3,8H2,1-2H3,(H,25,26) KUAJWLUTQNGTPS-UHFFFAOYSA-N 276719 US20260014125, Compound 58 S-adenosylmethionine synthase isoform type-2 Homo sapiens 14.8 US Patent 10.7270/Q2H99B1C US20260014125 LI, Z; YANG, J; TU, W; YU, B; ZHANG, Y; LI, L 1/15/2026 5/28/2026 Haihe Biopharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=276719 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=276719&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search 130309925 378158384 1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,30GH,30GD,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM S-adenosylmethionine synthase isoform type-2 METK2_HUMAN P31153 A8K511 B4DN45 D6W5L1 Q53SP5 191132 Cn1cc2cc(-n3c(=O)c(-c4ccc(Cl)cc4)c(OCCO)c4cn[nH]c43)ccc2n1 InChI=1S/C22H18ClN5O3/c1-27-12-14-10-16(6-7-18(14)26-27)28-21-17(11-24-25-21)20(31-9-8-29)19(22(28)30)13-2-4-15(23)5-3-13/h2-7,10-12,29H,8-9H2,1H3,(H,24,25) MIQRCMUSYWPQCU-UHFFFAOYSA-N 276720 US20260014125, Compound 59 S-adenosylmethionine synthase isoform type-2 Homo sapiens 20.7 US Patent 10.7270/Q2H99B1C US20260014125 LI, Z; YANG, J; TU, W; YU, B; ZHANG, Y; LI, L 1/15/2026 5/28/2026 Haihe Biopharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=276720 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=276720&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search 130309929 378158385 1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,30GH,30GD,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM S-adenosylmethionine synthase isoform type-2 METK2_HUMAN P31153 A8K511 B4DN45 D6W5L1 Q53SP5 191133 COCCOc1c(-c2ccc(Cl)cc2)c(=O)n(-c2ccc3nn(C)cc3c2)c2[nH]ncc12 InChI=1S/C23H20ClN5O3/c1-28-13-15-11-17(7-8-19(15)27-28)29-22-18(12-25-26-22)21(32-10-9-31-2)20(23(29)30)14-3-5-16(24)6-4-14/h3-8,11-13H,9-10H2,1-2H3,(H,25,26) XUPHDQUTLSCAIZ-UHFFFAOYSA-N 276721 US20260014125, Compound 60 S-adenosylmethionine synthase isoform type-2 Homo sapiens 14.2 US Patent 10.7270/Q2H99B1C US20260014125 LI, Z; YANG, J; TU, W; YU, B; ZHANG, Y; LI, L 1/15/2026 5/28/2026 Haihe Biopharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=276721 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=276721&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search 130309926 378158386 1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,30GH,30GD,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM S-adenosylmethionine synthase isoform type-2 METK2_HUMAN P31153 A8K511 B4DN45 D6W5L1 Q53SP5 191134 CCOc1c(C2CCCCC2)c(=O)n(-c2ccc3nn(C)cc3c2)c2[nH]ncc12 InChI=1S/C22H25N5O2/c1-3-29-20-17-12-23-24-21(17)27(22(28)19(20)14-7-5-4-6-8-14)16-9-10-18-15(11-16)13-26(2)25-18/h9-14H,3-8H2,1-2H3,(H,23,24) ULGVSKSNECMWMY-UHFFFAOYSA-N 276722 US20260014125, Compound 61 S-adenosylmethionine synthase isoform type-2 Homo sapiens 14.2 US Patent 10.7270/Q2H99B1C US20260014125 LI, Z; YANG, J; TU, W; YU, B; ZHANG, Y; LI, L 1/15/2026 5/28/2026 Haihe Biopharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=276722 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=276722&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search 130309923 378158387 1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,30GH,30GD,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM S-adenosylmethionine synthase isoform type-2 METK2_HUMAN P31153 A8K511 B4DN45 D6W5L1 Q53SP5 191135 CCOc1c(-c2ccc(Cl)cn2)c(=O)n(-c2ccc3nn(C)cc3c2)c2[nH]ncc12 InChI=1S/C21H17ClN6O2/c1-3-30-19-15-10-24-25-20(15)28(14-5-7-16-12(8-14)11-27(2)26-16)21(29)18(19)17-6-4-13(22)9-23-17/h4-11H,3H2,1-2H3,(H,24,25) LXQCSHFABPZHNE-UHFFFAOYSA-N 276723 US20260014125, Compound 62 S-adenosylmethionine synthase isoform type-2 Homo sapiens 18.0 US Patent 10.7270/Q2H99B1C US20260014125 LI, Z; YANG, J; TU, W; YU, B; ZHANG, Y; LI, L 1/15/2026 5/28/2026 Haihe Biopharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=276723 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=276723&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search 130309920 378158388 1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,30GH,30GD,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM S-adenosylmethionine synthase isoform type-2 METK2_HUMAN P31153 A8K511 B4DN45 D6W5L1 Q53SP5 191136 Cn5cc4cc(n3c(=O)c(c1ccc(Cl)cc1)c(NCC(F)(F)F)c2cn[nH]c23)ccc4n5 InChI=1S/C22H16ClF3N6O/c1-31-10-13-8-15(6-7-17(13)30-31)32-20-16(9-28-29-20)19(27-11-22(24,25)26)18(21(32)33)12-2-4-14(23)5-3-12/h2-10,27H,11H2,1H3,(H,28,29) SOAIZGKATPZETM-UHFFFAOYSA-N 276724 US20260014125, Compound 63 S-adenosylmethionine synthase isoform type-2 Homo sapiens 18.2 US Patent 10.7270/Q2H99B1C US20260014125 LI, Z; YANG, J; TU, W; YU, B; ZHANG, Y; LI, L 1/15/2026 5/28/2026 Haihe Biopharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=276724 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=276724&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search 130309932 378158389 1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,30GH,30GD,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM S-adenosylmethionine synthase isoform type-2 METK2_HUMAN P31153 A8K511 B4DN45 D6W5L1 Q53SP5 191137 CCN(C)c1c(-c2ccc(Cl)cc2)c(=O)n(-c2ccc3nn(C)cc3c2)c2[nH]ncc12 InChI=1S/C23H21ClN6O/c1-4-28(2)21-18-12-25-26-22(18)30(17-9-10-19-15(11-17)13-29(3)27-19)23(31)20(21)14-5-7-16(24)8-6-14/h5-13H,4H2,1-3H3,(H,25,26) KZXSAWDQTJSRFH-UHFFFAOYSA-N 276725 US20260014125, Compound 64 S-adenosylmethionine synthase isoform type-2 Homo sapiens 18.5 US Patent 10.7270/Q2H99B1C US20260014125 LI, Z; YANG, J; TU, W; YU, B; ZHANG, Y; LI, L 1/15/2026 5/28/2026 Haihe Biopharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=276725 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=276725&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search 130309924 378158390 1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,30GH,30GD,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM S-adenosylmethionine synthase isoform type-2 METK2_HUMAN P31153 A8K511 B4DN45 D6W5L1 Q53SP5 191138 CCOc1c(-c2ccc(C#N)cc2)c(=O)n(-c2ccc3nn(C)cc3c2)c2[nH]ncc12 InChI=1S/C23H18N6O2/c1-3-31-21-18-12-25-26-22(18)29(17-8-9-19-16(10-17)13-28(2)27-19)23(30)20(21)15-6-4-14(11-24)5-7-15/h4-10,12-13H,3H2,1-2H3,(H,25,26) OPQQWPCWKLECHX-UHFFFAOYSA-N 276726 US20260014125, Compound 65 S-adenosylmethionine synthase isoform type-2 Homo sapiens 16.0 US Patent 10.7270/Q2H99B1C US20260014125 LI, Z; YANG, J; TU, W; YU, B; ZHANG, Y; LI, L 1/15/2026 5/28/2026 Haihe Biopharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=276726 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=276726&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search 130309930 378158391 1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,30GH,30GD,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM S-adenosylmethionine synthase isoform type-2 METK2_HUMAN P31153 A8K511 B4DN45 D6W5L1 Q53SP5 191139 CCOc1c(-c2ccc(Cl)cc2)c(=O)n(-c2ccc3nn(C)c(C)c3c2)c2[nH]ncc12 InChI=1S/C23H20ClN5O2/c1-4-31-21-18-12-25-26-22(18)29(23(30)20(21)14-5-7-15(24)8-6-14)16-9-10-19-17(11-16)13(2)28(3)27-19/h5-12H,4H2,1-3H3,(H,25,26) SKGGVHXFYKIYME-UHFFFAOYSA-N 276727 US20260014125, Compound 66 S-adenosylmethionine synthase isoform type-2 Homo sapiens 13.7 US Patent 10.7270/Q2H99B1C US20260014125 LI, Z; YANG, J; TU, W; YU, B; ZHANG, Y; LI, L 1/15/2026 5/28/2026 Haihe Biopharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=276727 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=276727&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search 130309931 378158392 1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,30GH,30GD,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM S-adenosylmethionine synthase isoform type-2 METK2_HUMAN P31153 A8K511 B4DN45 D6W5L1 Q53SP5 191140 CCOc1c(-c2ccc(Cl)cc2)c(=O)n(-c2ccc3nn(C)cc3c2)c2[nH]cnc12 InChI=1S/C22H18ClN5O2/c1-3-30-20-18(13-4-6-15(23)7-5-13)22(29)28(21-19(20)24-12-25-21)16-8-9-17-14(10-16)11-27(2)26-17/h4-12H,3H2,1-2H3,(H,24,25) BTUITLDFZADKKR-UHFFFAOYSA-N 276728 US20260014125, Compound 67 S-adenosylmethionine synthase isoform type-2 Homo sapiens 17.8 US Patent 10.7270/Q2H99B1C US20260014125 LI, Z; YANG, J; TU, W; YU, B; ZHANG, Y; LI, L 1/15/2026 5/28/2026 Haihe Biopharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=276728 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=276728&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search 130302280 378158393 1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,30GH,30GD,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM S-adenosylmethionine synthase isoform type-2 METK2_HUMAN P31153 A8K511 B4DN45 D6W5L1 Q53SP5 191141 CCOc1c(-c2ccc(Cl)cc2)c(=O)n(-c2ccc3nn(C)cc3n2)c2[nH]ncc12 InChI=1S/C21H17ClN6O2/c1-3-30-19-14-10-23-25-20(14)28(17-9-8-15-16(24-17)11-27(2)26-15)21(29)18(19)12-4-6-13(22)7-5-12/h4-11H,3H2,1-2H3,(H,23,25) FWMTUVAYOFOMJO-UHFFFAOYSA-N 276729 US20260014125, Compound 84 S-adenosylmethionine synthase isoform type-2 Homo sapiens 20.7 US Patent 10.7270/Q2H99B1C US20260014125 LI, Z; YANG, J; TU, W; YU, B; ZHANG, Y; LI, L 1/15/2026 5/28/2026 Haihe Biopharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=276729 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=276729&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search 130302244 378158394 1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,30GH,30GD,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM S-adenosylmethionine synthase isoform type-2 METK2_HUMAN P31153 A8K511 B4DN45 D6W5L1 Q53SP5 191142 CCOc1c(-c2ccc(C)nc2)c(=O)n(-c2ccc3nn(C)cc3n2)c2[nH]ncc12 InChI=1S/C21H19N7O2/c1-4-30-19-14-10-23-25-20(14)28(17-8-7-15-16(24-17)11-27(3)26-15)21(29)18(19)13-6-5-12(2)22-9-13/h5-11H,4H2,1-3H3,(H,23,25) JSHIAEIFTTTWSS-UHFFFAOYSA-N 276730 US20260014125, Compound 86 S-adenosylmethionine synthase isoform type-2 Homo sapiens 20.3 US Patent 10.7270/Q2H99B1C US20260014125 LI, Z; YANG, J; TU, W; YU, B; ZHANG, Y; LI, L 1/15/2026 5/28/2026 Haihe Biopharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=276730 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=276730&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search 130302269 378158395 1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,30GH,30GD,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM S-adenosylmethionine synthase isoform type-2 METK2_HUMAN P31153 A8K511 B4DN45 D6W5L1 Q53SP5 191143 CCOc1c(-c2ccc(C(F)(F)F)nc2)c(=O)n(-c2ccc3nn(C)cc3n2)c2[nH]ncc12 InChI=1S/C21H16F3N7O2/c1-3-33-18-12-9-26-28-19(12)31(16-7-5-13-14(27-16)10-30(2)29-13)20(32)17(18)11-4-6-15(25-8-11)21(22,23)24/h4-10H,3H2,1-2H3,(H,26,28) HSIIXFAKVVNVJL-UHFFFAOYSA-N 276731 US20260014125, Compound 87 S-adenosylmethionine synthase isoform type-2 Homo sapiens 28.3 US Patent 10.7270/Q2H99B1C US20260014125 LI, Z; YANG, J; TU, W; YU, B; ZHANG, Y; LI, L 1/15/2026 5/28/2026 Haihe Biopharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=276731 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=276731&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search 130302392 378158396 1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,30GH,30GD,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM S-adenosylmethionine synthase isoform type-2 METK2_HUMAN P31153 A8K511 B4DN45 D6W5L1 Q53SP5 191144 Cc5ccc(c4c(OCC(F)(F)F)c1cn[nH]c1n(c3ccc2nn(C)cc2n3)c4=O)cn5 InChI=1S/C21H16F3N7O2/c1-11-3-4-12(7-25-11)17-18(33-10-21(22,23)24)13-8-26-28-19(13)31(20(17)32)16-6-5-14-15(27-16)9-30(2)29-14/h3-9H,10H2,1-2H3,(H,26,28) IUBQVKNNMSVQIB-UHFFFAOYSA-N 276732 US20260014125, Compound 89 S-adenosylmethionine synthase isoform type-2 Homo sapiens 16.0 US Patent 10.7270/Q2H99B1C US20260014125 LI, Z; YANG, J; TU, W; YU, B; ZHANG, Y; LI, L 1/15/2026 5/28/2026 Haihe Biopharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=276732 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=276732&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search 130302278 378158397 1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,30GH,30GD,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM S-adenosylmethionine synthase isoform type-2 METK2_HUMAN P31153 A8K511 B4DN45 D6W5L1 Q53SP5 191145 CCOc1c(-c2ccc(Cl)cc2)c(=O)n(-c2ccc3nn(C4COC4)cc3c2)c2[nH]ncc12 InChI=1S/C24H20ClN5O3/c1-2-33-22-19-10-26-27-23(19)30(24(31)21(22)14-3-5-16(25)6-4-14)17-7-8-20-15(9-17)11-29(28-20)18-12-32-13-18/h3-11,18H,2,12-13H2,1H3,(H,26,27) LCTRESCIFICOJG-UHFFFAOYSA-N 276733 US20260014125, Compound 90 S-adenosylmethionine synthase isoform type-2 Homo sapiens 18.2 US Patent 10.7270/Q2H99B1C US20260014125 LI, Z; YANG, J; TU, W; YU, B; ZHANG, Y; LI, L 1/15/2026 5/28/2026 Haihe Biopharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=276733 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=276733&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search 130302258 378158398 1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,30GH,30GD,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM S-adenosylmethionine synthase isoform type-2 METK2_HUMAN P31153 A8K511 B4DN45 D6W5L1 Q53SP5 191146 CCOc1c(-c2ccc(C(F)(F)F)nc2)c(=O)n(-c2ccc3nn(C4COC4)cc3c2)c2[nH]ncc12 InChI=1S/C24H19F3N6O3/c1-2-36-21-17-9-29-30-22(17)33(23(34)20(21)13-3-6-19(28-8-13)24(25,26)27)15-4-5-18-14(7-15)10-32(31-18)16-11-35-12-16/h3-10,16H,2,11-12H2,1H3,(H,29,30) IMEQQRPYTNPPNV-UHFFFAOYSA-N 276734 US20260014125, Compound 92 S-adenosylmethionine synthase isoform type-2 Homo sapiens 19.1 US Patent 10.7270/Q2H99B1C US20260014125 LI, Z; YANG, J; TU, W; YU, B; ZHANG, Y; LI, L 1/15/2026 5/28/2026 Haihe Biopharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=276734 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=276734&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search 130302326 378158399 1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,30GH,30GD,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM S-adenosylmethionine synthase isoform type-2 METK2_HUMAN P31153 A8K511 B4DN45 D6W5L1 Q53SP5 191147 O=c3c(c1ccc(Cl)cc1)c(OCC(F)(F)F)c2cn[nH]c2n3c6ccc5nn(C4COC4)cc5c6 InChI=1S/C24H17ClF3N5O3/c25-15-3-1-13(2-4-15)20-21(36-12-24(26,27)28)18-8-29-30-22(18)33(23(20)34)16-5-6-19-14(7-16)9-32(31-19)17-10-35-11-17/h1-9,17H,10-12H2,(H,29,30) DSXNJDIVGBRWBC-UHFFFAOYSA-N 276735 US20260014125, Compound 93 S-adenosylmethionine synthase isoform type-2 Homo sapiens 16.2 US Patent 10.7270/Q2H99B1C US20260014125 LI, Z; YANG, J; TU, W; YU, B; ZHANG, Y; LI, L 1/15/2026 5/28/2026 Haihe Biopharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=276735 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=276735&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search 130302354 378158400 1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,30GH,30GD,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM S-adenosylmethionine synthase isoform type-2 METK2_HUMAN P31153 A8K511 B4DN45 D6W5L1 Q53SP5 191148 Cn1cc2nc(-n3c(=O)c(-c4ccc(Cl)cc4)c(OCC4CC4)c4cn[nH]c43)ccc2n1 InChI=1S/C23H19ClN6O2/c1-29-11-18-17(28-29)8-9-19(26-18)30-22-16(10-25-27-22)21(32-12-13-2-3-13)20(23(30)31)14-4-6-15(24)7-5-14/h4-11,13H,2-3,12H2,1H3,(H,25,27) SXDNCCQENPCCMT-UHFFFAOYSA-N 276736 US20260014125, Compound 96 S-adenosylmethionine synthase isoform type-2 Homo sapiens 17.6 US Patent 10.7270/Q2H99B1C US20260014125 LI, Z; YANG, J; TU, W; YU, B; ZHANG, Y; LI, L 1/15/2026 5/28/2026 Haihe Biopharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=276736 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=276736&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search 130309933 378158401 1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,30GH,30GD,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM S-adenosylmethionine synthase isoform type-2 METK2_HUMAN P31153 A8K511 B4DN45 D6W5L1 Q53SP5 191149 CCOc4c(c1ccc(Cl)cc1)c(=O)n(c3ccc2nn(C(F)(F)F)cc2n3)c5[nH]ncc45 InChI=1S/C21H14ClF3N6O2/c1-2-33-18-13-9-26-28-19(13)31(20(32)17(18)11-3-5-12(22)6-4-11)16-8-7-14-15(27-16)10-30(29-14)21(23,24)25/h3-10H,2H2,1H3,(H,26,28) WALKYOFXFWRCBT-UHFFFAOYSA-N 276737 US20260014125, Compound 99 S-adenosylmethionine synthase isoform type-2 Homo sapiens 16.1 US Patent 10.7270/Q2H99B1C US20260014125 LI, Z; YANG, J; TU, W; YU, B; ZHANG, Y; LI, L 1/15/2026 5/28/2026 Haihe Biopharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=276737 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=276737&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search 130302253 378158402 1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,30GH,30GD,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM S-adenosylmethionine synthase isoform type-2 METK2_HUMAN P31153 A8K511 B4DN45 D6W5L1 Q53SP5 191150 CCOc1c(-c2ccc(Cl)cc2)c(=O)n(-c2ccc3nn(C)cc3c2)c2cnn(C)c12 InChI=1S/C23H20ClN5O2/c1-4-31-22-20(14-5-7-16(24)8-6-14)23(30)29(19-12-25-28(3)21(19)22)17-9-10-18-15(11-17)13-27(2)26-18/h5-13H,4H2,1-3H3 ANBLNYPEJCHIHS-UHFFFAOYSA-N 276738 US20260014125, Compound 100 S-adenosylmethionine synthase isoform type-2 Homo sapiens 62.4 US Patent 10.7270/Q2H99B1C US20260014125 LI, Z; YANG, J; TU, W; YU, B; ZHANG, Y; LI, L 1/15/2026 5/28/2026 Haihe Biopharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=276738 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=276738&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search 130309934 378158403 1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,30GH,30GD,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM S-adenosylmethionine synthase isoform type-2 METK2_HUMAN P31153 A8K511 B4DN45 D6W5L1 Q53SP5 191151 CCOc1c(-c2ccc(C)nc2)c(=O)n(-c2ccc3nn(CC)cc3c2)c2[nH]ncc12 InChI=1S/C23H22N6O2/c1-4-28-13-16-10-17(8-9-19(16)27-28)29-22-18(12-25-26-22)21(31-5-2)20(23(29)30)15-7-6-14(3)24-11-15/h6-13H,4-5H2,1-3H3,(H,25,26) YDOYSJQFYWVXBM-UHFFFAOYSA-N 276739 US20260014125, Compound 101 S-adenosylmethionine synthase isoform type-2 Homo sapiens 17.4 US Patent 10.7270/Q2H99B1C US20260014125 LI, Z; YANG, J; TU, W; YU, B; ZHANG, Y; LI, L 1/15/2026 5/28/2026 Haihe Biopharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=276739 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=276739&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search 130302316 378158404 1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,30GH,30GD,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM S-adenosylmethionine synthase isoform type-2 METK2_HUMAN P31153 A8K511 B4DN45 D6W5L1 Q53SP5 191152 CCOc1c(-c2ccc(C(F)(F)F)nc2)c(=O)n(-c2ccc3nn(CC)cc3c2)c2[nH]ncc12 InChI=1S/C23H19F3N6O2/c1-3-31-12-14-9-15(6-7-17(14)30-31)32-21-16(11-28-29-21)20(34-4-2)19(22(32)33)13-5-8-18(27-10-13)23(24,25)26/h5-12H,3-4H2,1-2H3,(H,28,29) ZJTHZBQAPZGCKQ-UHFFFAOYSA-N 276740 US20260014125, Compound 102 S-adenosylmethionine synthase isoform type-2 Homo sapiens 20.6 US Patent 10.7270/Q2H99B1C US20260014125 LI, Z; YANG, J; TU, W; YU, B; ZHANG, Y; LI, L 1/15/2026 5/28/2026 Haihe Biopharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=276740 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=276740&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search 130302214 378158405 1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,30GH,30GD,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM S-adenosylmethionine synthase isoform type-2 METK2_HUMAN P31153 A8K511 B4DN45 D6W5L1 Q53SP5 191153 Cn1cc2cc(-n3c(=O)c(-c4ccc(C(F)(F)F)nc4)c(OCC4CC4)c4cn[nH]c43)ccc2n1 InChI=1S/C24H19F3N6O2/c1-32-11-15-8-16(5-6-18(15)31-32)33-22-17(10-29-30-22)21(35-12-13-2-3-13)20(23(33)34)14-4-7-19(28-9-14)24(25,26)27/h4-11,13H,2-3,12H2,1H3,(H,29,30) VPXDTINJMYLRAF-UHFFFAOYSA-N 285604 US20260014125, Compound 104 S-adenosylmethionine synthase isoform type-2 Homo sapiens 15.7 US Patent 10.7270/Q2H99B1C US20260014125 LI, Z; YANG, J; TU, W; YU, B; ZHANG, Y; LI, L 1/15/2026 5/28/2026 Haihe Biopharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=285604 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=285604&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search 118857198 378169243 1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,30GH,30GD,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM S-adenosylmethionine synthase isoform type-2 METK2_HUMAN P31153 A8K511 B4DN45 D6W5L1 Q53SP5 191154 CCNc1c(-c2ccc(Cl)cc2)c(=O)n(-c2ccc3nn(C)cc3n2)c2[nH]ncc12 InChI=1S/C21H18ClN7O/c1-3-23-19-14-10-24-26-20(14)29(17-9-8-15-16(25-17)11-28(2)27-15)21(30)18(19)12-4-6-13(22)7-5-12/h4-11,23H,3H2,1-2H3,(H,24,26) VGTHSVRIVGQCSX-UHFFFAOYSA-N 285605 US20260014125, Compound 105 S-adenosylmethionine synthase isoform type-2 Homo sapiens 19.6 US Patent 10.7270/Q2H99B1C US20260014125 LI, Z; YANG, J; TU, W; YU, B; ZHANG, Y; LI, L 1/15/2026 5/28/2026 Haihe Biopharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=285605 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=285605&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search 131972585 378169244 1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,30GH,30GD,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM S-adenosylmethionine synthase isoform type-2 METK2_HUMAN P31153 A8K511 B4DN45 D6W5L1 Q53SP5 191155 CCNc1c(-c2ccc(C(F)(F)F)nc2)c(=O)n(-c2ccc3nn(C)cc3c2)c2[nH]ncc12 InChI=1S/C22H18F3N7O/c1-3-26-19-15-10-28-29-20(15)32(14-5-6-16-13(8-14)11-31(2)30-16)21(33)18(19)12-4-7-17(27-9-12)22(23,24)25/h4-11,26H,3H2,1-2H3,(H,28,29) MKGHRXITMWTFAV-UHFFFAOYSA-N 285606 US20260014125, Compound 106 S-adenosylmethionine synthase isoform type-2 Homo sapiens 28.8 US Patent 10.7270/Q2H99B1C US20260014125 LI, Z; YANG, J; TU, W; YU, B; ZHANG, Y; LI, L 1/15/2026 5/28/2026 Haihe Biopharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=285606 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=285606&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search 118857197 378169245 1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,30GH,30GD,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM S-adenosylmethionine synthase isoform type-2 METK2_HUMAN P31153 A8K511 B4DN45 D6W5L1 Q53SP5 191156 Cn1cc2nc(-n3c(=O)c(-c4ccc(Cl)cc4)c(NCC4CC4)c4cn[nH]c43)ccc2n1 InChI=1S/C23H20ClN7O/c1-30-12-18-17(29-30)8-9-19(27-18)31-22-16(11-26-28-22)21(25-10-13-2-3-13)20(23(31)32)14-4-6-15(24)7-5-14/h4-9,11-13,25H,2-3,10H2,1H3,(H,26,28) YAOLUUYRUFLIJT-UHFFFAOYSA-N 291172 US20260014125, Compound 107 S-adenosylmethionine synthase isoform type-2 Homo sapiens 16.7 US Patent 10.7270/Q2H99B1C US20260014125 LI, Z; YANG, J; TU, W; YU, B; ZHANG, Y; LI, L 1/15/2026 5/28/2026 Haihe Biopharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=291172 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=291172&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search 126624206 381611478 1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,30GH,30GD,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM S-adenosylmethionine synthase isoform type-2 METK2_HUMAN P31153 A8K511 B4DN45 D6W5L1 Q53SP5 191157 Cn1cc2cc(-n3c(=O)c(-c4ccc(C(F)(F)F)nc4)c(NCC4CC4)c4cn[nH]c43)ccc2n1 InChI=1S/C24H20F3N7O/c1-33-12-15-8-16(5-6-18(15)32-33)34-22-17(11-30-31-22)21(29-9-13-2-3-13)20(23(34)35)14-4-7-19(28-10-14)24(25,26)27/h4-8,10-13,29H,2-3,9H2,1H3,(H,30,31) MOTDNRIEKUQBRG-UHFFFAOYSA-N 291174 US20260014125, Compound 108 S-adenosylmethionine synthase isoform type-2 Homo sapiens 17.3 US Patent 10.7270/Q2H99B1C US20260014125 LI, Z; YANG, J; TU, W; YU, B; ZHANG, Y; LI, L 1/15/2026 5/28/2026 Haihe Biopharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=291174 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=291174&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search 137528692 381611480 1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,30GH,30GD,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM S-adenosylmethionine synthase isoform type-2 METK2_HUMAN P31153 A8K511 B4DN45 D6W5L1 Q53SP5 191158 CCOc1c(-c2ccc(Cl)cc2)c(=O)n(-c2ccc3nn(C)cc3n2)c2nn(C)cc12 InChI=1S/C22H19ClN6O2/c1-4-31-20-15-11-27(2)26-21(15)29(18-10-9-16-17(24-18)12-28(3)25-16)22(30)19(20)13-5-7-14(23)8-6-13/h5-12H,4H2,1-3H3 HFDRARZLCALJGG-UHFFFAOYSA-N 291177 US20260014125, Compound 109 S-adenosylmethionine synthase isoform type-2 Homo sapiens 23.2 US Patent 10.7270/Q2H99B1C US20260014125 LI, Z; YANG, J; TU, W; YU, B; ZHANG, Y; LI, L 1/15/2026 5/28/2026 Haihe Biopharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=291177 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=291177&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search 129012357 381611483 1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,30GH,30GD,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM S-adenosylmethionine synthase isoform type-2 METK2_HUMAN P31153 A8K511 B4DN45 D6W5L1 Q53SP5 191159 CCOc1c(-c2ccc(Cl)cc2)c(=O)n(-c2ccc3nn(CCN(C)C)cc3c2)c2[nH]ncc12 InChI=1S/C25H25ClN6O2/c1-4-34-23-20-14-27-28-24(20)32(25(33)22(23)16-5-7-18(26)8-6-16)19-9-10-21-17(13-19)15-31(29-21)12-11-30(2)3/h5-10,13-15H,4,11-12H2,1-3H3,(H,27,28) IATZTCDRFBVCID-UHFFFAOYSA-N 291179 US20260014125, Compound 111 S-adenosylmethionine synthase isoform type-2 Homo sapiens 17.5 US Patent 10.7270/Q2H99B1C US20260014125 LI, Z; YANG, J; TU, W; YU, B; ZHANG, Y; LI, L 1/15/2026 5/28/2026 Haihe Biopharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=291179 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=291179&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search 137528693 381611484 1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,30GH,30GD,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM S-adenosylmethionine synthase isoform type-2 METK2_HUMAN P31153 A8K511 B4DN45 D6W5L1 Q53SP5 191160 CCCc1c(-c2ccc(Cl)cc2)c(=O)n(-c2ccc3nn(C)cc3c2)c2[nH]ncc12 InChI=1S/C23H20ClN5O/c1-3-4-18-19-12-25-26-22(19)29(17-9-10-20-15(11-17)13-28(2)27-20)23(30)21(18)14-5-7-16(24)8-6-14/h5-13H,3-4H2,1-2H3,(H,25,26) RPQNHRKCSMZBOH-UHFFFAOYSA-N 291180 US20260014125, Compound 112 S-adenosylmethionine synthase isoform type-2 Homo sapiens 18.3 US Patent 10.7270/Q2H99B1C US20260014125 LI, Z; YANG, J; TU, W; YU, B; ZHANG, Y; LI, L 1/15/2026 5/28/2026 Haihe Biopharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=291180 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=291180&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search 137528694 381611485 1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,30GH,30GD,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM S-adenosylmethionine synthase isoform type-2 METK2_HUMAN P31153 A8K511 B4DN45 D6W5L1 Q53SP5 191161 CCOc1c(-c2ccc(Cl)cc2)c(=O)n(-c2ccn3nccc3c2)c2[nH]ncc12 InChI=1S/C21H16ClN5O2/c1-2-29-19-17-12-23-25-20(17)27(16-8-10-26-15(11-16)7-9-24-26)21(28)18(19)13-3-5-14(22)6-4-13/h3-12H,2H2,1H3,(H,23,25) LVUPEPRYCLGIHT-UHFFFAOYSA-N 291181 US20260014125, Compound 114 S-adenosylmethionine synthase isoform type-2 Homo sapiens 67.3 US Patent 10.7270/Q2H99B1C US20260014125 LI, Z; YANG, J; TU, W; YU, B; ZHANG, Y; LI, L 1/15/2026 5/28/2026 Haihe Biopharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=291181 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=291181&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search 137528695 381611486 1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,30GH,30GD,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM S-adenosylmethionine synthase isoform type-2 METK2_HUMAN P31153 A8K511 B4DN45 D6W5L1 Q53SP5 191162 CCOc1c(-c2ccc(Cl)cc2)c(=O)n(-c2ccn3nc(C)cc3n2)c2[nH]ncc12 InChI=1S/C21H17ClN6O2/c1-3-30-19-15-11-23-25-20(15)28(16-8-9-27-17(24-16)10-12(2)26-27)21(29)18(19)13-4-6-14(22)7-5-13/h4-11H,3H2,1-2H3,(H,23,25) ARAPLUHJFKPYEW-UHFFFAOYSA-N 291188 US20260014125, Compound 116 S-adenosylmethionine synthase isoform type-2 Homo sapiens 335 US Patent 10.7270/Q2H99B1C US20260014125 LI, Z; YANG, J; TU, W; YU, B; ZHANG, Y; LI, L 1/15/2026 5/28/2026 Haihe Biopharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=291188 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=291188&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search 137528696 381611493 1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,30GH,30GD,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM S-adenosylmethionine synthase isoform type-2 METK2_HUMAN P31153 A8K511 B4DN45 D6W5L1 Q53SP5 191163 CCOc1c(-c2ccc(C)cc2)c(=O)n(-c2ccc3nn(C)cc3c2)c2[nH]ncc12 InChI=1S/C23H21N5O2/c1-4-30-21-18-12-24-25-22(18)28(17-9-10-19-16(11-17)13-27(3)26-19)23(29)20(21)15-7-5-14(2)6-8-15/h5-13H,4H2,1-3H3,(H,24,25) AJKGZKMWFZTZBP-UHFFFAOYSA-N 291192 US20260014125, Compound 117 S-adenosylmethionine synthase isoform type-2 Homo sapiens 17.2 US Patent 10.7270/Q2H99B1C US20260014125 LI, Z; YANG, J; TU, W; YU, B; ZHANG, Y; LI, L 1/15/2026 5/28/2026 Haihe Biopharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=291192 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=291192&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search 129012358 381611497 1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,30GH,30GD,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM S-adenosylmethionine synthase isoform type-2 METK2_HUMAN P31153 A8K511 B4DN45 D6W5L1 Q53SP5 191164 CCOc1c(-c2ccc(F)c(F)c2)c(=O)n(-c2ccc3nn(C)cc3c2)c2[nH]ncc12 InChI=1S/C22H17F2N5O2/c1-3-31-20-15-10-25-26-21(15)29(14-5-7-18-13(8-14)11-28(2)27-18)22(30)19(20)12-4-6-16(23)17(24)9-12/h4-11H,3H2,1-2H3,(H,25,26) ZSSJECMIMPGBRU-UHFFFAOYSA-N 292711 US20260014125, Compound 118 S-adenosylmethionine synthase isoform type-2 Homo sapiens 16.0 US Patent 10.7270/Q2H99B1C US20260014125 LI, Z; YANG, J; TU, W; YU, B; ZHANG, Y; LI, L 1/15/2026 5/28/2026 Haihe Biopharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=292711 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=292711&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search 124122982 381613000 1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,30GH,30GD,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM S-adenosylmethionine synthase isoform type-2 METK2_HUMAN P31153 A8K511 B4DN45 D6W5L1 Q53SP5 191165 CCOc1c(-c2ccc(Cl)cc2)c(=O)n(-c2ccc3nn(C)cc3n2)c2c1cnn2C InChI=1S/C22H19ClN6O2/c1-4-31-20-15-11-24-28(3)21(15)29(18-10-9-16-17(25-18)12-27(2)26-16)22(30)19(20)13-5-7-14(23)8-6-13/h5-12H,4H2,1-3H3 WBHKVNKVNNJAOE-UHFFFAOYSA-N 292718 US20260014125, Compound 121 S-adenosylmethionine synthase isoform type-2 Homo sapiens 1117 US Patent 10.7270/Q2H99B1C US20260014125 LI, Z; YANG, J; TU, W; YU, B; ZHANG, Y; LI, L 1/15/2026 5/28/2026 Haihe Biopharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=292718 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=292718&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search 124123342 381613007 1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,30GH,30GD,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM S-adenosylmethionine synthase isoform type-2 METK2_HUMAN P31153 A8K511 B4DN45 D6W5L1 Q53SP5 191166 CCOc1c(-c2ccc(Cl)cc2)c(=O)n(-c2ccc3nn(C)cc3c2)c2nn(CCO)cc12 InChI=1S/C24H22ClN5O3/c1-3-33-22-19-14-29(10-11-31)27-23(19)30(18-8-9-20-16(12-18)13-28(2)26-20)24(32)21(22)15-4-6-17(25)7-5-15/h4-9,12-14,31H,3,10-11H2,1-2H3 UHIRWBGNSOJXTF-UHFFFAOYSA-N 292719 US20260014125, Compound 122 S-adenosylmethionine synthase isoform type-2 Homo sapiens 27.7 US Patent 10.7270/Q2H99B1C US20260014125 LI, Z; YANG, J; TU, W; YU, B; ZHANG, Y; LI, L 1/15/2026 5/28/2026 Haihe Biopharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=292719 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=292719&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search 124123066 381613008 1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,30GH,30GD,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM S-adenosylmethionine synthase isoform type-2 METK2_HUMAN P31153 A8K511 B4DN45 D6W5L1 Q53SP5 191167 Cn1cc2cc(-n3c(=O)c(-c4ccc(Cl)cc4)c(NCC4CC4)c4cn[nH]c43)ccc2n1 InChI=1S/C24H21ClN6O/c1-30-13-16-10-18(8-9-20(16)29-30)31-23-19(12-27-28-23)22(26-11-14-2-3-14)21(24(31)32)15-4-6-17(25)7-5-15/h4-10,12-14,26H,2-3,11H2,1H3,(H,27,28) YSHVLDBZSPUOJL-UHFFFAOYSA-N 292720 US20260014125, Compound 123 S-adenosylmethionine synthase isoform type-2 Homo sapiens 11.7 US Patent 10.7270/Q2H99B1C US20260014125 LI, Z; YANG, J; TU, W; YU, B; ZHANG, Y; LI, L 1/15/2026 5/28/2026 Haihe Biopharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=292720 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=292720&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search 124123555 381613009 1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,30GH,30GD,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM S-adenosylmethionine synthase isoform type-2 METK2_HUMAN P31153 A8K511 B4DN45 D6W5L1 Q53SP5 191168 CCOc1c(-c2cnc(C(F)(F)F)nc2)c(=O)n(-c2ccc3nn(C)cc3c2)c2[nH]ncc12 InChI=1S/C21H16F3N7O2/c1-3-33-17-14-9-27-28-18(14)31(13-4-5-15-11(6-13)10-30(2)29-15)19(32)16(17)12-7-25-20(26-8-12)21(22,23)24/h4-10H,3H2,1-2H3,(H,27,28) XOKMSHWVYGSFMW-UHFFFAOYSA-N 292722 US20260014125, Compound 124 S-adenosylmethionine synthase isoform type-2 Homo sapiens 18.0 US Patent 10.7270/Q2H99B1C US20260014125 LI, Z; YANG, J; TU, W; YU, B; ZHANG, Y; LI, L 1/15/2026 5/28/2026 Haihe Biopharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=292722 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=292722&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search 124122899 381613010 1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,30GH,30GD,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM S-adenosylmethionine synthase isoform type-2 METK2_HUMAN P31153 A8K511 B4DN45 D6W5L1 Q53SP5 191169 CCOc1c(-c2ccc(=O)[nH]c2)c(=O)n(-c2ccc3nn(C)cc3c2)c2[nH]ncc12 InChI=1S/C21H18N6O3/c1-3-30-19-15-10-23-24-20(15)27(14-5-6-16-13(8-14)11-26(2)25-16)21(29)18(19)12-4-7-17(28)22-9-12/h4-11H,3H2,1-2H3,(H,22,28)(H,23,24) ZCWMNKQFLIZGEQ-UHFFFAOYSA-N 292723 US20260014125, Compound 125 S-adenosylmethionine synthase isoform type-2 Homo sapiens 45.3 US Patent 10.7270/Q2H99B1C US20260014125 LI, Z; YANG, J; TU, W; YU, B; ZHANG, Y; LI, L 1/15/2026 5/28/2026 Haihe Biopharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=292723 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=292723&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search 124123531 381613011 1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,30GH,30GD,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM S-adenosylmethionine synthase isoform type-2 METK2_HUMAN P31153 A8K511 B4DN45 D6W5L1 Q53SP5 191170 CCOc1c(-c2ccc(OC)nc2)c(=O)n(-c2ccc3nn(C)cc3c2)c2[nH]ncc12 InChI=1S/C22H20N6O3/c1-4-31-20-16-11-24-25-21(16)28(15-6-7-17-14(9-15)12-27(2)26-17)22(29)19(20)13-5-8-18(30-3)23-10-13/h5-12H,4H2,1-3H3,(H,24,25) HUCOWFUHTCDCPF-UHFFFAOYSA-N 292724 US20260014125, Compound 126 S-adenosylmethionine synthase isoform type-2 Homo sapiens 12.6 US Patent 10.7270/Q2H99B1C US20260014125 LI, Z; YANG, J; TU, W; YU, B; ZHANG, Y; LI, L 1/15/2026 5/28/2026 Haihe Biopharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=292724 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=292724&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search 124123634 381613012 1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,30GH,30GD,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM S-adenosylmethionine synthase isoform type-2 METK2_HUMAN P31153 A8K511 B4DN45 D6W5L1 Q53SP5 191171 CCOc1c(-c2ccc(Cl)cc2)c(=O)n(-c2ccc3nn(C)nc3c2)c2[nH]ncc12 InChI=1S/C21H17ClN6O2/c1-3-30-19-15-11-23-24-20(15)28(14-8-9-16-17(10-14)26-27(2)25-16)21(29)18(19)12-4-6-13(22)7-5-12/h4-11H,3H2,1-2H3,(H,23,24) IDRNWHZKRQGFIK-UHFFFAOYSA-N 292725 US20260014125, Compound 127 S-adenosylmethionine synthase isoform type-2 Homo sapiens 12.4 US Patent 10.7270/Q2H99B1C US20260014125 LI, Z; YANG, J; TU, W; YU, B; ZHANG, Y; LI, L 1/15/2026 5/28/2026 Haihe Biopharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=292725 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=292725&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search 124123855 381613013 1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,30GH,30GD,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM S-adenosylmethionine synthase isoform type-2 METK2_HUMAN P31153 A8K511 B4DN45 D6W5L1 Q53SP5 191172 CCOc1c(-c2ccc(Cl)cc2)c(=O)n(-c2ccc3nnn(C)c3c2)c2[nH]ncc12 InChI=1S/C21H17ClN6O2/c1-3-30-19-15-11-23-25-20(15)28(14-8-9-16-17(10-14)27(2)26-24-16)21(29)18(19)12-4-6-13(22)7-5-12/h4-11H,3H2,1-2H3,(H,23,25) NTBXNKYDOMZOIW-UHFFFAOYSA-N 292726 US20260014125, Compound 128 S-adenosylmethionine synthase isoform type-2 Homo sapiens 8.60 US Patent 10.7270/Q2H99B1C US20260014125 LI, Z; YANG, J; TU, W; YU, B; ZHANG, Y; LI, L 1/15/2026 5/28/2026 Haihe Biopharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=292726 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=292726&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search 124123306 381613014 1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,30GH,30GD,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM S-adenosylmethionine synthase isoform type-2 METK2_HUMAN P31153 A8K511 B4DN45 D6W5L1 Q53SP5 191173 CCNc1c(-c2ccc(OC(F)F)cc2)c(=O)n(-c2ccc3nn(C)cc3n2)c2[nH]ncc12 InChI=1S/C22H19F2N7O2/c1-3-25-19-14-10-26-28-20(14)31(17-9-8-15-16(27-17)11-30(2)29-15)21(32)18(19)12-4-6-13(7-5-12)33-22(23)24/h4-11,22,25H,3H2,1-2H3,(H,26,28) RIVONXVCROTBEK-UHFFFAOYSA-N 292727 US20260014125, Compound 129 S-adenosylmethionine synthase isoform type-2 Homo sapiens 17.8 US Patent 10.7270/Q2H99B1C US20260014125 LI, Z; YANG, J; TU, W; YU, B; ZHANG, Y; LI, L 1/15/2026 5/28/2026 Haihe Biopharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=292727 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=292727&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search 124123660 381613015 1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,30GH,30GD,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM S-adenosylmethionine synthase isoform type-2 METK2_HUMAN P31153 A8K511 B4DN45 D6W5L1 Q53SP5 191174 CCSc1c(-c2ccc(Cl)cc2)c(=O)n(-c2ccc3nn(C)cc3c2)c2[nH]ncc12 InChI=1S/C22H18ClN5OS/c1-3-30-20-17-11-24-25-21(17)28(16-8-9-18-14(10-16)12-27(2)26-18)22(29)19(20)13-4-6-15(23)7-5-13/h4-12H,3H2,1-2H3,(H,24,25) RTPWMHZYTUOKRK-UHFFFAOYSA-N 292728 US20260014125, Compound 130 S-adenosylmethionine synthase isoform type-2 Homo sapiens 11.2 US Patent 10.7270/Q2H99B1C US20260014125 LI, Z; YANG, J; TU, W; YU, B; ZHANG, Y; LI, L 1/15/2026 5/28/2026 Haihe Biopharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=292728 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=292728&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search 124123659 381613016 1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,30GH,30GD,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM S-adenosylmethionine synthase isoform type-2 METK2_HUMAN P31153 A8K511 B4DN45 D6W5L1 Q53SP5 191175 CCOc1c(-c2ccc(Cl)cc2)c(=O)n(-c2ccc3c(cnn3CCN(C)C)c2)c2[nH]ncc12 InChI=1S/C25H25ClN6O2/c1-4-34-23-20-15-27-29-24(20)32(25(33)22(23)16-5-7-18(26)8-6-16)19-9-10-21-17(13-19)14-28-31(21)12-11-30(2)3/h5-10,13-15H,4,11-12H2,1-3H3,(H,27,29) GHLAHPBOFUBZCU-UHFFFAOYSA-N 292729 US20260014125, Compound 131 S-adenosylmethionine synthase isoform type-2 Homo sapiens 36.2 US Patent 10.7270/Q2H99B1C US20260014125 LI, Z; YANG, J; TU, W; YU, B; ZHANG, Y; LI, L 1/15/2026 5/28/2026 Haihe Biopharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=292729 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=292729&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search 124123480 381613017 1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,30GH,30GD,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM S-adenosylmethionine synthase isoform type-2 METK2_HUMAN P31153 A8K511 B4DN45 D6W5L1 Q53SP5 191176 CCOc1c(-c2ccc(Cl)cc2)c(=O)n(-c2ccc3nn(CCN(C)C)cc3n2)c2[nH]ncc12 InChI=1S/C24H24ClN7O2/c1-4-34-22-17-13-26-28-23(17)32(24(33)21(22)15-5-7-16(25)8-6-15)20-10-9-18-19(27-20)14-31(29-18)12-11-30(2)3/h5-10,13-14H,4,11-12H2,1-3H3,(H,26,28) XTYNVVBYGNYZPA-UHFFFAOYSA-N 292730 US20260014125, Compound 132 S-adenosylmethionine synthase isoform type-2 Homo sapiens 16.5 US Patent 10.7270/Q2H99B1C US20260014125 LI, Z; YANG, J; TU, W; YU, B; ZHANG, Y; LI, L 1/15/2026 5/28/2026 Haihe Biopharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=292730 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=292730&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search 124123714 381613018 1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,30GH,30GD,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM S-adenosylmethionine synthase isoform type-2 METK2_HUMAN P31153 A8K511 B4DN45 D6W5L1 Q53SP5 191177 CCOc1c(-c2ccc(C)cc2)c(=O)n(-c2ccc3nn(C)cc3n2)c2[nH]ncc12 InChI=1S/C22H20N6O2/c1-4-30-20-15-11-23-25-21(15)28(18-10-9-16-17(24-18)12-27(3)26-16)22(29)19(20)14-7-5-13(2)6-8-14/h5-12H,4H2,1-3H3,(H,23,25) SSJWLXIWFSDRJA-UHFFFAOYSA-N 292731 US20260014125, Compound 133 S-adenosylmethionine synthase isoform type-2 Homo sapiens 27.4 US Patent 10.7270/Q2H99B1C US20260014125 LI, Z; YANG, J; TU, W; YU, B; ZHANG, Y; LI, L 1/15/2026 5/28/2026 Haihe Biopharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=292731 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=292731&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search 124123300 381613019 1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,30GH,30GD,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM S-adenosylmethionine synthase isoform type-2 METK2_HUMAN P31153 A8K511 B4DN45 D6W5L1 Q53SP5 191178 CCOc1c(-c2ccc(Cl)cc2)c(=O)n(-c2ccc3nn(C)cc3c2)c2nn(C)cc12 InChI=1S/C23H20ClN5O2/c1-4-31-21-18-13-28(3)26-22(18)29(17-9-10-19-15(11-17)12-27(2)25-19)23(30)20(21)14-5-7-16(24)8-6-14/h5-13H,4H2,1-3H3 RMZCJGHBWQBICE-UHFFFAOYSA-N 292732 US20260014125, Compound 134 S-adenosylmethionine synthase isoform type-2 Homo sapiens 19.1 US Patent 10.7270/Q2H99B1C US20260014125 LI, Z; YANG, J; TU, W; YU, B; ZHANG, Y; LI, L 1/15/2026 5/28/2026 Haihe Biopharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=292732 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=292732&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search 124123488 381613020 1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,30GH,30GD,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM S-adenosylmethionine synthase isoform type-2 METK2_HUMAN P31153 A8K511 B4DN45 D6W5L1 Q53SP5 191179 CCOc1c(-c2ccc(Cl)cc2)c(=O)n(-c2ccc3nn(C)nc3c2)c2nn(C)cc12 InChI=1S/C22H19ClN6O2/c1-4-31-20-16-12-27(2)26-21(16)29(15-9-10-17-18(11-15)25-28(3)24-17)22(30)19(20)13-5-7-14(23)8-6-13/h5-12H,4H2,1-3H3 ZBMCVJQNYRMOGA-UHFFFAOYSA-N 292733 US20260014125, Compound 136 S-adenosylmethionine synthase isoform type-2 Homo sapiens 17.9 US Patent 10.7270/Q2H99B1C US20260014125 LI, Z; YANG, J; TU, W; YU, B; ZHANG, Y; LI, L 1/15/2026 5/28/2026 Haihe Biopharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=292733 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=292733&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search 124123406 381613021 1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,30GH,30GD,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM S-adenosylmethionine synthase isoform type-2 METK2_HUMAN P31153 A8K511 B4DN45 D6W5L1 Q53SP5 191180 CCOc1c(-c2ccc(Cl)cc2)c(=O)n(-c2ccc3nn(C)nc3n2)c2[nH]ncc12 InChI=1S/C20H16ClN7O2/c1-3-30-17-13-10-22-24-19(13)28(15-9-8-14-18(23-15)26-27(2)25-14)20(29)16(17)11-4-6-12(21)7-5-11/h4-10H,3H2,1-2H3,(H,22,24) CTZILPNROQLYIF-UHFFFAOYSA-N 292734 US20260014125, Compound 137 S-adenosylmethionine synthase isoform type-2 Homo sapiens 16.8 US Patent 10.7270/Q2H99B1C US20260014125 LI, Z; YANG, J; TU, W; YU, B; ZHANG, Y; LI, L 1/15/2026 5/28/2026 Haihe Biopharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=292734 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=292734&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search 124123775 381613022 1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,30GH,30GD,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM S-adenosylmethionine synthase isoform type-2 METK2_HUMAN P31153 A8K511 B4DN45 D6W5L1 Q53SP5 191181 CCOc1c(-c2ccc(Cl)cc2)c(=O)n(-c2ccc3nn(C)nc3n2)c2nn(C)cc12 InChI=1S/C21H18ClN7O2/c1-4-31-18-14-11-27(2)26-20(14)29(16-10-9-15-19(23-16)25-28(3)24-15)21(30)17(18)12-5-7-13(22)8-6-12/h5-11H,4H2,1-3H3 CBCRYXXUPSGRQL-UHFFFAOYSA-N 292735 US20260014125, Compound 138 S-adenosylmethionine synthase isoform type-2 Homo sapiens 50.7 US Patent 10.7270/Q2H99B1C US20260014125 LI, Z; YANG, J; TU, W; YU, B; ZHANG, Y; LI, L 1/15/2026 5/28/2026 Haihe Biopharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=292735 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=292735&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search 124123419 381613023 1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,30GH,30GD,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM S-adenosylmethionine synthase isoform type-2 METK2_HUMAN P31153 A8K511 B4DN45 D6W5L1 Q53SP5 191182 CCOc1c(-c2ccc(Cl)cc2)c(=O)n(-c2ccc3c(cnn3CCN(C)C)n2)c2[nH]ncc12 InChI=1S/C24H24ClN7O2/c1-4-34-22-17-13-26-29-23(17)32(24(33)21(22)15-5-7-16(25)8-6-15)20-10-9-19-18(28-20)14-27-31(19)12-11-30(2)3/h5-10,13-14H,4,11-12H2,1-3H3,(H,26,29) UBHFJTXOPSNLPG-UHFFFAOYSA-N 292736 US20260014125, Compound 139 S-adenosylmethionine synthase isoform type-2 Homo sapiens 376 US Patent 10.7270/Q2H99B1C US20260014125 LI, Z; YANG, J; TU, W; YU, B; ZHANG, Y; LI, L 1/15/2026 5/28/2026 Haihe Biopharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=292736 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=292736&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search 124123954 381613024 1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,30GH,30GD,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM S-adenosylmethionine synthase isoform type-2 METK2_HUMAN P31153 A8K511 B4DN45 D6W5L1 Q53SP5 191183 CCOc1c(-c2ccc(Cl)cc2)c(=O)n(-c2ccc3nnn(C)c3c2)c2nn(C)cc12 InChI=1S/C22H19ClN6O2/c1-4-31-20-16-12-27(2)25-21(16)29(15-9-10-17-18(11-15)28(3)26-24-17)22(30)19(20)13-5-7-14(23)8-6-13/h5-12H,4H2,1-3H3 FUPBIWWEKOPPBP-UHFFFAOYSA-N 292737 US20260014125, Compound 140 S-adenosylmethionine synthase isoform type-2 Homo sapiens 13.0 US Patent 10.7270/Q2H99B1C US20260014125 LI, Z; YANG, J; TU, W; YU, B; ZHANG, Y; LI, L 1/15/2026 5/28/2026 Haihe Biopharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=292737 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=292737&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search 124123627 381613025 1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,30GH,30GD,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM S-adenosylmethionine synthase isoform type-2 METK2_HUMAN P31153 A8K511 B4DN45 D6W5L1 Q53SP5 191184 CCOc1c(-c2ccc(Cl)cc2)c(=O)n(C2=NC3C(C=C2)N=NN3C)c2[nH]ncc12 InChI=1S/C20H18ClN7O2/c1-3-30-17-13-10-22-25-18(13)28(15-9-8-14-19(23-15)27(2)26-24-14)20(29)16(17)11-4-6-12(21)7-5-11/h4-10,14,19H,3H2,1-2H3,(H,22,25) SPYMZRCGSIXLNG-UHFFFAOYSA-N 292738 US20260014125, Compound 141 S-adenosylmethionine synthase isoform type-2 Homo sapiens 16.7 US Patent 10.7270/Q2H99B1C US20260014125 LI, Z; YANG, J; TU, W; YU, B; ZHANG, Y; LI, L 1/15/2026 5/28/2026 Haihe Biopharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=292738 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=292738&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search 124123597 381613026 1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,30GH,30GD,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM S-adenosylmethionine synthase isoform type-2 METK2_HUMAN P31153 A8K511 B4DN45 D6W5L1 Q53SP5 191185 [2H]C([2H])([2H])C([2H])([2H])Oc1c(-c2ccc(Cl)cc2)c(=O)n(-c2ccc3nn(C)cc3c2)c2[nH]ncc12 InChI=1S/C22H18ClN5O2/c1-3-30-20-17-11-24-25-21(17)28(16-8-9-18-14(10-16)12-27(2)26-18)22(29)19(20)13-4-6-15(23)7-5-13/h4-12H,3H2,1-2H3,(H,24,25)/i1D3,3D2 NLZAMUQMLQRAKZ-WNWXXORZSA-N 292739 US20260014125, Compound 142 S-adenosylmethionine synthase isoform type-2 Homo sapiens 10.3 US Patent 10.7270/Q2H99B1C US20260014125 LI, Z; YANG, J; TU, W; YU, B; ZHANG, Y; LI, L 1/15/2026 5/28/2026 Haihe Biopharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=292739 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1085&target=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=292739&enzyme=S-adenosylmethionine+synthase+isoform+type-2&column=ki&startPg=0&Increment=50&submit=Search 124123514 381613027 1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 9QPP,9QPO,8XJ2,8QE3,8QE2,8QE1,8QE0,8QDZ,8QDY,8OOG,7RWH,7RWG,7RW7,7RW5,7LNH,7KDB,7KDA,7KCF,7KCE,7KCC,7BHX,7BHW,7BHV,7BHU,7BHT,7BHS,7BHR,6WKB,6G6R,6FAJ,5A1I,5A1G,5A19,4NDN,4KTV,4KTT,30GH,30GD,2P02,8XB0,8XAR,8AXZ,7RXX,7RXW,7RXV,7L1A,5UGH,6FWB,8P4H,8P1W,8P1V,8P1T,8XAM S-adenosylmethionine synthase isoform type-2 METK2_HUMAN P31153 A8K511 B4DN45 D6W5L1 Q53SP5