BindingDB Reactant_set_id	Ligand SMILES	Ligand InChI	Ligand InChI Key	BindingDB MonomerID	BindingDB Ligand Name	Target Name	Target Source Organism According to Curator or DataSource	Ki (nM)	IC50 (nM)	Kd (nM)	EC50 (nM)	kon (M-1-s-1)	koff (s-1)	pH	Temp (C)	Curation/DataSource	Article DOI	BindingDB Entry DOI	PMID	PubChem AID	Patent Number	Authors	Date of publication	Date in BindingDB	Institution	Link to Ligand in BindingDB	Link to Target in BindingDB	Link to Ligand-Target Pair in BindingDB	Ligand HET ID in PDB	PDB ID(s) for Ligand-Target Complex	PubChem CID	PubChem SID	ChEBI ID of Ligand	ChEMBL ID of Ligand	DrugBank ID of Ligand	IUPHAR_GRAC ID of Ligand	KEGG ID of Ligand	ZINC ID of Ligand	Number of Protein Chains in Target (>1 implies a multichain complex)	BindingDB Target Chain Sequence 1	PDB ID(s) of Target Chain 1	UniProt (SwissProt) Recommended Name of Target Chain 1	UniProt (SwissProt) Entry Name of Target Chain 1	UniProt (SwissProt) Primary ID of Target Chain 1	UniProt (SwissProt) Secondary ID(s) of Target Chain 1	UniProt (SwissProt) Alternative ID(s) of Target Chain 1	UniProt (TrEMBL) Submitted Name of Target Chain 1	UniProt (TrEMBL) Entry Name of Target Chain 1	UniProt (TrEMBL) Primary ID of Target Chain 1	UniProt (TrEMBL) Secondary ID(s) of Target Chain 1	UniProt (TrEMBL) Alternative ID(s) of Target Chain 1	BindingDB Target Chain Sequence 2	PDB ID(s) of Target Chain 2	UniProt (SwissProt) Recommended Name of Target Chain 2	UniProt (SwissProt) Entry Name of Target Chain 2	UniProt (SwissProt) Primary ID of Target Chain 2	UniProt (SwissProt) Secondary ID(s) of Target Chain 2	UniProt (SwissProt) Alternative ID(s) of Target Chain 2	UniProt (TrEMBL) Submitted Name of Target Chain 2	UniProt (TrEMBL) Entry Name of Target Chain 2	UniProt (TrEMBL) Primary ID of Target Chain 2	UniProt (TrEMBL) Secondary ID(s) of Target Chain 2	UniProt (TrEMBL) Alternative ID(s) of Target Chain 2	BindingDB Target Chain Sequence 3	PDB ID(s) of Target Chain 3	UniProt (SwissProt) Recommended Name of Target Chain 3	UniProt (SwissProt) Entry Name of Target Chain 3	UniProt (SwissProt) Primary ID of Target Chain 3	UniProt (SwissProt) Secondary ID(s) of Target Chain 3	UniProt (SwissProt) Alternative ID(s) of Target Chain 3	UniProt (TrEMBL) Submitted Name of Target Chain 3	UniProt (TrEMBL) Entry Name of Target Chain 3	UniProt (TrEMBL) Primary ID of Target Chain 3	UniProt (TrEMBL) Secondary ID(s) of Target Chain 3	UniProt (TrEMBL) Alternative ID(s) of Target Chain 3	BindingDB Target Chain Sequence 4	PDB ID(s) of Target Chain 4	UniProt (SwissProt) Recommended Name of Target Chain 4	UniProt (SwissProt) Entry Name of Target Chain 4	UniProt (SwissProt) Primary ID of Target Chain 4	UniProt (SwissProt) Secondary ID(s) of Target Chain 4	UniProt (SwissProt) Alternative ID(s) of Target Chain 4	UniProt (TrEMBL) Submitted Name of Target Chain 4	UniProt (TrEMBL) Entry Name of Target Chain 4	UniProt (TrEMBL) Primary ID of Target Chain 4	UniProt (TrEMBL) Secondary ID(s) of Target Chain 4	UniProt (TrEMBL) Alternative ID(s) of Target Chain 4	BindingDB Target Chain Sequence 5	PDB ID(s) of Target Chain 5	UniProt (SwissProt) Recommended Name of Target Chain 5	UniProt (SwissProt) Entry Name of Target Chain 5	UniProt (SwissProt) Primary ID of Target Chain 5	UniProt (SwissProt) Secondary ID(s) of Target Chain 5	UniProt (SwissProt) Alternative ID(s) of Target Chain 5	UniProt (TrEMBL) Submitted Name of Target Chain 5	UniProt (TrEMBL) Entry Name of Target Chain 5	UniProt (TrEMBL) Primary ID of Target Chain 5	UniProt (TrEMBL) Secondary ID(s) of Target Chain 5	UniProt (TrEMBL) Alternative ID(s) of Target Chain 5	BindingDB Target Chain Sequence 6	PDB ID(s) of Target Chain 6	UniProt (SwissProt) Recommended Name of Target Chain 6	UniProt (SwissProt) Entry Name of Target Chain 6	UniProt (SwissProt) Primary ID of Target Chain 6	UniProt (SwissProt) Secondary ID(s) of Target Chain 6	UniProt (SwissProt) Alternative ID(s) of Target Chain 6	UniProt (TrEMBL) Submitted Name of Target Chain 6	UniProt (TrEMBL) Entry Name of Target Chain 6	UniProt (TrEMBL) Primary ID of Target Chain 6	UniProt (TrEMBL) Secondary ID(s) of Target Chain 6	UniProt (TrEMBL) Alternative ID(s) of Target Chain 6	BindingDB Target Chain Sequence 7	PDB ID(s) of Target Chain 7	UniProt (SwissProt) Recommended Name of Target Chain 7	UniProt (SwissProt) Entry Name of Target Chain 7	UniProt (SwissProt) Primary ID of Target Chain 7	UniProt (SwissProt) Secondary ID(s) of Target Chain 7	UniProt (SwissProt) Alternative ID(s) of Target Chain 7	UniProt (TrEMBL) Submitted Name of Target Chain 7	UniProt (TrEMBL) Entry Name of Target Chain 7	UniProt (TrEMBL) Primary ID of Target Chain 7	UniProt (TrEMBL) Secondary ID(s) of Target Chain 7	UniProt (TrEMBL) Alternative ID(s) of Target Chain 7	BindingDB Target Chain Sequence 8	PDB ID(s) of Target Chain 8	UniProt (SwissProt) Recommended Name of Target Chain 8	UniProt (SwissProt) Entry Name of Target Chain 8	UniProt (SwissProt) Primary ID of Target Chain 8	UniProt (SwissProt) Secondary ID(s) of Target Chain 8	UniProt (SwissProt) Alternative ID(s) of Target Chain 8	UniProt (TrEMBL) Submitted Name of Target Chain 8	UniProt (TrEMBL) Entry Name of Target Chain 8	UniProt (TrEMBL) Primary ID of Target Chain 8	UniProt (TrEMBL) Secondary ID(s) of Target Chain 8	UniProt (TrEMBL) Alternative ID(s) of Target Chain 8	BindingDB Target Chain Sequence 9	PDB ID(s) of Target Chain 9	UniProt (SwissProt) Recommended Name of Target Chain 9	UniProt (SwissProt) Entry Name of Target Chain 9	UniProt (SwissProt) Primary ID of Target Chain 9	UniProt (SwissProt) Secondary ID(s) of Target Chain 9	UniProt (SwissProt) Alternative ID(s) of Target Chain 9	UniProt (TrEMBL) Submitted Name of Target Chain 9	UniProt (TrEMBL) Entry Name of Target Chain 9	UniProt (TrEMBL) Primary ID of Target Chain 9	UniProt (TrEMBL) Secondary ID(s) of Target Chain 9	UniProt (TrEMBL) Alternative ID(s) of Target Chain 9	BindingDB Target Chain Sequence 10	PDB ID(s) of Target Chain 10	UniProt (SwissProt) Recommended Name of Target Chain 10	UniProt (SwissProt) Entry Name of Target Chain 10	UniProt (SwissProt) Primary ID of Target Chain 10	UniProt (SwissProt) Secondary ID(s) of Target Chain 10	UniProt (SwissProt) Alternative ID(s) of Target Chain 10	UniProt (TrEMBL) Submitted Name of Target Chain 10	UniProt (TrEMBL) Entry Name of Target Chain 10	UniProt (TrEMBL) Primary ID of Target Chain 10	UniProt (TrEMBL) Secondary ID(s) of Target Chain 10	UniProt (TrEMBL) Alternative ID(s) of Target Chain 10	BindingDB Target Chain Sequence 11	PDB ID(s) of Target Chain 11	UniProt (SwissProt) Recommended Name of Target Chain 11	UniProt (SwissProt) Entry Name of Target Chain 11	UniProt (SwissProt) Primary ID of Target Chain 11	UniProt (SwissProt) Secondary ID(s) of Target Chain 11	UniProt (SwissProt) Alternative ID(s) of Target Chain 11	UniProt (TrEMBL) Submitted Name of Target Chain 11	UniProt (TrEMBL) Entry Name of Target Chain 11	UniProt (TrEMBL) Primary ID of Target Chain 11	UniProt (TrEMBL) Secondary ID(s) of Target Chain 11	UniProt (TrEMBL) Alternative ID(s) of Target Chain 11	BindingDB Target Chain Sequence 12	PDB ID(s) of Target Chain 12	UniProt (SwissProt) Recommended Name of Target Chain 12	UniProt (SwissProt) Entry Name of Target Chain 12	UniProt (SwissProt) Primary ID of Target Chain 12	UniProt (SwissProt) Secondary ID(s) of Target Chain 12	UniProt (SwissProt) Alternative ID(s) of Target Chain 12	UniProt (TrEMBL) Submitted Name of Target Chain 12	UniProt (TrEMBL) Entry Name of Target Chain 12	UniProt (TrEMBL) Primary ID of Target Chain 12	UniProt (TrEMBL) Secondary ID(s) of Target Chain 12	UniProt (TrEMBL) Alternative ID(s) of Target Chain 12	BindingDB Target Chain Sequence 13	PDB ID(s) of Target Chain 13	UniProt (SwissProt) Recommended Name of Target Chain 13	UniProt (SwissProt) Entry Name of Target Chain 13	UniProt (SwissProt) Primary ID of Target Chain 13	UniProt (SwissProt) Secondary ID(s) of Target Chain 13	UniProt (SwissProt) Alternative ID(s) of Target Chain 13	UniProt (TrEMBL) Submitted Name of Target Chain 13	UniProt (TrEMBL) Entry Name of Target Chain 13	UniProt (TrEMBL) Primary ID of Target Chain 13	UniProt (TrEMBL) Secondary ID(s) of Target Chain 13	UniProt (TrEMBL) Alternative ID(s) of Target Chain 13	BindingDB Target Chain Sequence 14	PDB ID(s) of Target Chain 14	UniProt (SwissProt) Recommended Name of Target Chain 14	UniProt (SwissProt) Entry Name of Target Chain 14	UniProt (SwissProt) Primary ID of Target Chain 14	UniProt (SwissProt) Secondary ID(s) of Target Chain 14	UniProt (SwissProt) Alternative ID(s) of Target Chain 14	UniProt (TrEMBL) Submitted Name of Target Chain 14	UniProt (TrEMBL) Entry Name of Target Chain 14	UniProt (TrEMBL) Primary ID of Target Chain 14	UniProt (TrEMBL) Secondary ID(s) of Target Chain 14	UniProt (TrEMBL) Alternative ID(s) of Target Chain 14	BindingDB Target Chain Sequence 15	PDB ID(s) of Target Chain 15	UniProt (SwissProt) Recommended Name of Target Chain 15	UniProt (SwissProt) Entry Name of Target Chain 15	UniProt (SwissProt) Primary ID of Target Chain 15	UniProt (SwissProt) Secondary ID(s) of Target Chain 15	UniProt (SwissProt) Alternative ID(s) of Target Chain 15	UniProt (TrEMBL) Submitted Name of Target Chain 15	UniProt (TrEMBL) Entry Name of Target Chain 15	UniProt (TrEMBL) Primary ID of Target Chain 15	UniProt (TrEMBL) Secondary ID(s) of Target Chain 15	UniProt (TrEMBL) Alternative ID(s) of Target Chain 15	BindingDB Target Chain Sequence 16	PDB ID(s) of Target Chain 16	UniProt (SwissProt) Recommended Name of Target Chain 16	UniProt (SwissProt) Entry Name of Target Chain 16	UniProt (SwissProt) Primary ID of Target Chain 16	UniProt (SwissProt) Secondary ID(s) of Target Chain 16	UniProt (SwissProt) Alternative ID(s) of Target Chain 16	UniProt (TrEMBL) Submitted Name of Target Chain 16	UniProt (TrEMBL) Entry Name of Target Chain 16	UniProt (TrEMBL) Primary ID of Target Chain 16	UniProt (TrEMBL) Secondary ID(s) of Target Chain 16	UniProt (TrEMBL) Alternative ID(s) of Target Chain 16	BindingDB Target Chain Sequence 17	PDB ID(s) of Target Chain 17	UniProt (SwissProt) Recommended Name of Target Chain 17	UniProt (SwissProt) Entry Name of Target Chain 17	UniProt (SwissProt) Primary ID of Target Chain 17	UniProt (SwissProt) Secondary ID(s) of Target Chain 17	UniProt (SwissProt) Alternative ID(s) of Target Chain 17	UniProt (TrEMBL) Submitted Name of Target Chain 17	UniProt (TrEMBL) Entry Name of Target Chain 17	UniProt (TrEMBL) Primary ID of Target Chain 17	UniProt (TrEMBL) Secondary ID(s) of Target Chain 17	UniProt (TrEMBL) Alternative ID(s) of Target Chain 17	BindingDB Target Chain Sequence 18	PDB ID(s) of Target Chain 18	UniProt (SwissProt) Recommended Name of Target Chain 18	UniProt (SwissProt) Entry Name of Target Chain 18	UniProt (SwissProt) Primary ID of Target Chain 18	UniProt (SwissProt) Secondary ID(s) of Target Chain 18	UniProt (SwissProt) Alternative ID(s) of Target Chain 18	UniProt (TrEMBL) Submitted Name of Target Chain 18	UniProt (TrEMBL) Entry Name of Target Chain 18	UniProt (TrEMBL) Primary ID of Target Chain 18	UniProt (TrEMBL) Secondary ID(s) of Target Chain 18	UniProt (TrEMBL) Alternative ID(s) of Target Chain 18	BindingDB Target Chain Sequence 19	PDB ID(s) of Target Chain 19	UniProt (SwissProt) Recommended Name of Target Chain 19	UniProt (SwissProt) Entry Name of Target Chain 19	UniProt (SwissProt) Primary ID of Target Chain 19	UniProt (SwissProt) Secondary ID(s) of Target Chain 19	UniProt (SwissProt) Alternative ID(s) of Target Chain 19	UniProt (TrEMBL) Submitted Name of Target Chain 19	UniProt (TrEMBL) Entry Name of Target Chain 19	UniProt (TrEMBL) Primary ID of Target Chain 19	UniProt (TrEMBL) Secondary ID(s) of Target Chain 19	UniProt (TrEMBL) Alternative ID(s) of Target Chain 19	BindingDB Target Chain Sequence 20	PDB ID(s) of Target Chain 20	UniProt (SwissProt) Recommended Name of Target Chain 20	UniProt (SwissProt) Entry Name of Target Chain 20	UniProt (SwissProt) Primary ID of Target Chain 20	UniProt (SwissProt) Secondary ID(s) of Target Chain 20	UniProt (SwissProt) Alternative ID(s) of Target Chain 20	UniProt (TrEMBL) Submitted Name of Target Chain 20	UniProt (TrEMBL) Entry Name of Target Chain 20	UniProt (TrEMBL) Primary ID of Target Chain 20	UniProt (TrEMBL) Secondary ID(s) of Target Chain 20	UniProt (TrEMBL) Alternative ID(s) of Target Chain 20	BindingDB Target Chain Sequence 21	PDB ID(s) of Target Chain 21	UniProt (SwissProt) Recommended Name of Target Chain 21	UniProt (SwissProt) Entry Name of Target Chain 21	UniProt (SwissProt) Primary ID of Target Chain 21	UniProt (SwissProt) Secondary ID(s) of Target Chain 21	UniProt (SwissProt) Alternative ID(s) of Target Chain 21	UniProt (TrEMBL) Submitted Name of Target Chain 21	UniProt (TrEMBL) Entry Name of Target Chain 21	UniProt (TrEMBL) Primary ID of Target Chain 21	UniProt (TrEMBL) Secondary ID(s) of Target Chain 21	UniProt (TrEMBL) Alternative ID(s) of Target Chain 21	BindingDB Target Chain Sequence 22	PDB ID(s) of Target Chain 22	UniProt (SwissProt) Recommended Name of Target Chain 22	UniProt (SwissProt) Entry Name of Target Chain 22	UniProt (SwissProt) Primary ID of Target Chain 22	UniProt (SwissProt) Secondary ID(s) of Target Chain 22	UniProt (SwissProt) Alternative ID(s) of Target Chain 22	UniProt (TrEMBL) Submitted Name of Target Chain 22	UniProt (TrEMBL) Entry Name of Target Chain 22	UniProt (TrEMBL) Primary ID of Target Chain 22	UniProt (TrEMBL) Secondary ID(s) of Target Chain 22	UniProt (TrEMBL) Alternative ID(s) of Target Chain 22	BindingDB Target Chain Sequence 23	PDB ID(s) of Target Chain 23	UniProt (SwissProt) Recommended Name of Target Chain 23	UniProt (SwissProt) Entry Name of Target Chain 23	UniProt (SwissProt) Primary ID of Target Chain 23	UniProt (SwissProt) Secondary ID(s) of Target Chain 23	UniProt (SwissProt) Alternative ID(s) of Target Chain 23	UniProt (TrEMBL) Submitted Name of Target Chain 23	UniProt (TrEMBL) Entry Name of Target Chain 23	UniProt (TrEMBL) Primary ID of Target Chain 23	UniProt (TrEMBL) Secondary ID(s) of Target Chain 23	UniProt (TrEMBL) Alternative ID(s) of Target Chain 23	BindingDB Target Chain Sequence 24	PDB ID(s) of Target Chain 24	UniProt (SwissProt) Recommended Name of Target Chain 24	UniProt (SwissProt) Entry Name of Target Chain 24	UniProt (SwissProt) Primary ID of Target Chain 24	UniProt (SwissProt) Secondary ID(s) of Target Chain 24	UniProt (SwissProt) Alternative ID(s) of Target Chain 24	UniProt (TrEMBL) Submitted Name of Target Chain 24	UniProt (TrEMBL) Entry Name of Target Chain 24	UniProt (TrEMBL) Primary ID of Target Chain 24	UniProt (TrEMBL) Secondary ID(s) of Target Chain 24	UniProt (TrEMBL) Alternative ID(s) of Target Chain 24	BindingDB Target Chain Sequence 25	PDB ID(s) of Target Chain 25	UniProt (SwissProt) Recommended Name of Target Chain 25	UniProt (SwissProt) Entry Name of Target Chain 25	UniProt (SwissProt) Primary ID of Target Chain 25	UniProt (SwissProt) Secondary ID(s) of Target Chain 25	UniProt (SwissProt) Alternative ID(s) of Target Chain 25	UniProt (TrEMBL) Submitted Name of Target Chain 25	UniProt (TrEMBL) Entry Name of Target Chain 25	UniProt (TrEMBL) Primary ID of Target Chain 25	UniProt (TrEMBL) Secondary ID(s) of Target Chain 25	UniProt (TrEMBL) Alternative ID(s) of Target Chain 25	BindingDB Target Chain Sequence 26	PDB ID(s) of Target Chain 26	UniProt (SwissProt) Recommended Name of Target Chain 26	UniProt (SwissProt) Entry Name of Target Chain 26	UniProt (SwissProt) Primary ID of Target Chain 26	UniProt (SwissProt) Secondary ID(s) of Target Chain 26	UniProt (SwissProt) Alternative ID(s) of Target Chain 26	UniProt (TrEMBL) Submitted Name of Target Chain 26	UniProt (TrEMBL) Entry Name of Target Chain 26	UniProt (TrEMBL) Primary ID of Target Chain 26	UniProt (TrEMBL) Secondary ID(s) of Target Chain 26	UniProt (TrEMBL) Alternative ID(s) of Target Chain 26	BindingDB Target Chain Sequence 27	PDB ID(s) of Target Chain 27	UniProt (SwissProt) Recommended Name of Target Chain 27	UniProt (SwissProt) Entry Name of Target Chain 27	UniProt (SwissProt) Primary ID of Target Chain 27	UniProt (SwissProt) Secondary ID(s) of Target Chain 27	UniProt (SwissProt) Alternative ID(s) of Target Chain 27	UniProt (TrEMBL) Submitted Name of Target Chain 27	UniProt (TrEMBL) Entry Name of Target Chain 27	UniProt (TrEMBL) Primary ID of Target Chain 27	UniProt (TrEMBL) Secondary ID(s) of Target Chain 27	UniProt (TrEMBL) Alternative ID(s) of Target Chain 27	BindingDB Target Chain Sequence 28	PDB ID(s) of Target Chain 28	UniProt (SwissProt) Recommended Name of Target Chain 28	UniProt (SwissProt) Entry Name of Target Chain 28	UniProt (SwissProt) Primary ID of Target Chain 28	UniProt (SwissProt) Secondary ID(s) of Target Chain 28	UniProt (SwissProt) Alternative ID(s) of Target Chain 28	UniProt (TrEMBL) Submitted Name of Target Chain 28	UniProt (TrEMBL) Entry Name of Target Chain 28	UniProt (TrEMBL) Primary ID of Target Chain 28	UniProt (TrEMBL) Secondary ID(s) of Target Chain 28	UniProt (TrEMBL) Alternative ID(s) of Target Chain 28	BindingDB Target Chain Sequence 29	PDB ID(s) of Target Chain 29	UniProt (SwissProt) Recommended Name of Target Chain 29	UniProt (SwissProt) Entry Name of Target Chain 29	UniProt (SwissProt) Primary ID of Target Chain 29	UniProt (SwissProt) Secondary ID(s) of Target Chain 29	UniProt (SwissProt) Alternative ID(s) of Target Chain 29	UniProt (TrEMBL) Submitted Name of Target Chain 29	UniProt (TrEMBL) Entry Name of Target Chain 29	UniProt (TrEMBL) Primary ID of Target Chain 29	UniProt (TrEMBL) Secondary ID(s) of Target Chain 29	UniProt (TrEMBL) Alternative ID(s) of Target Chain 29	BindingDB Target Chain Sequence 30	PDB ID(s) of Target Chain 30	UniProt (SwissProt) Recommended Name of Target Chain 30	UniProt (SwissProt) Entry Name of Target Chain 30	UniProt (SwissProt) Primary ID of Target Chain 30	UniProt (SwissProt) Secondary ID(s) of Target Chain 30	UniProt (SwissProt) Alternative ID(s) of Target Chain 30	UniProt (TrEMBL) Submitted Name of Target Chain 30	UniProt (TrEMBL) Entry Name of Target Chain 30	UniProt (TrEMBL) Primary ID of Target Chain 30	UniProt (TrEMBL) Secondary ID(s) of Target Chain 30	UniProt (TrEMBL) Alternative ID(s) of Target Chain 30	BindingDB Target Chain Sequence 31	PDB ID(s) of Target Chain 31	UniProt (SwissProt) Recommended Name of Target Chain 31	UniProt (SwissProt) Entry Name of Target Chain 31	UniProt (SwissProt) Primary ID of Target Chain 31	UniProt (SwissProt) Secondary ID(s) of Target Chain 31	UniProt (SwissProt) Alternative ID(s) of Target Chain 31	UniProt (TrEMBL) Submitted Name of Target Chain 31	UniProt (TrEMBL) Entry Name of Target Chain 31	UniProt (TrEMBL) Primary ID of Target Chain 31	UniProt (TrEMBL) Secondary ID(s) of Target Chain 31	UniProt (TrEMBL) Alternative ID(s) of Target Chain 31	BindingDB Target Chain Sequence 32	PDB ID(s) of Target Chain 32	UniProt (SwissProt) Recommended Name of Target Chain 32	UniProt (SwissProt) Entry Name of Target Chain 32	UniProt (SwissProt) Primary ID of Target Chain 32	UniProt (SwissProt) Secondary ID(s) of Target Chain 32	UniProt (SwissProt) Alternative ID(s) of Target Chain 32	UniProt (TrEMBL) Submitted Name of Target Chain 32	UniProt (TrEMBL) Entry Name of Target Chain 32	UniProt (TrEMBL) Primary ID of Target Chain 32	UniProt (TrEMBL) Secondary ID(s) of Target Chain 32	UniProt (TrEMBL) Alternative ID(s) of Target Chain 32	BindingDB Target Chain Sequence 33	PDB ID(s) of Target Chain 33	UniProt (SwissProt) Recommended Name of Target Chain 33	UniProt (SwissProt) Entry Name of Target Chain 33	UniProt (SwissProt) Primary ID of Target Chain 33	UniProt (SwissProt) Secondary ID(s) of Target Chain 33	UniProt (SwissProt) Alternative ID(s) of Target Chain 33	UniProt (TrEMBL) Submitted Name of Target Chain 33	UniProt (TrEMBL) Entry Name of Target Chain 33	UniProt (TrEMBL) Primary ID of Target Chain 33	UniProt (TrEMBL) Secondary ID(s) of Target Chain 33	UniProt (TrEMBL) Alternative ID(s) of Target Chain 33	BindingDB Target Chain Sequence 34	PDB ID(s) of Target Chain 34	UniProt (SwissProt) Recommended Name of Target Chain 34	UniProt (SwissProt) Entry Name of Target Chain 34	UniProt (SwissProt) Primary ID of Target Chain 34	UniProt (SwissProt) Secondary ID(s) of Target Chain 34	UniProt (SwissProt) Alternative ID(s) of Target Chain 34	UniProt (TrEMBL) Submitted Name of Target Chain 34	UniProt (TrEMBL) Entry Name of Target Chain 34	UniProt (TrEMBL) Primary ID of Target Chain 34	UniProt (TrEMBL) Secondary ID(s) of Target Chain 34	UniProt (TrEMBL) Alternative ID(s) of Target Chain 34	BindingDB Target Chain Sequence 35	PDB ID(s) of Target Chain 35	UniProt (SwissProt) Recommended Name of Target Chain 35	UniProt (SwissProt) Entry Name of Target Chain 35	UniProt (SwissProt) Primary ID of Target Chain 35	UniProt (SwissProt) Secondary ID(s) of Target Chain 35	UniProt (SwissProt) Alternative ID(s) of Target Chain 35	UniProt (TrEMBL) Submitted Name of Target Chain 35	UniProt (TrEMBL) Entry Name of Target Chain 35	UniProt (TrEMBL) Primary ID of Target Chain 35	UniProt (TrEMBL) Secondary ID(s) of Target Chain 35	UniProt (TrEMBL) Alternative ID(s) of Target Chain 35	BindingDB Target Chain Sequence 36	PDB ID(s) of Target Chain 36	UniProt (SwissProt) Recommended Name of Target Chain 36	UniProt (SwissProt) Entry Name of Target Chain 36	UniProt (SwissProt) Primary ID of Target Chain 36	UniProt (SwissProt) Secondary ID(s) of Target Chain 36	UniProt (SwissProt) Alternative ID(s) of Target Chain 36	UniProt (TrEMBL) Submitted Name of Target Chain 36	UniProt (TrEMBL) Entry Name of Target Chain 36	UniProt (TrEMBL) Primary ID of Target Chain 36	UniProt (TrEMBL) Secondary ID(s) of Target Chain 36	UniProt (TrEMBL) Alternative ID(s) of Target Chain 36	BindingDB Target Chain Sequence 37	PDB ID(s) of Target Chain 37	UniProt (SwissProt) Recommended Name of Target Chain 37	UniProt (SwissProt) Entry Name of Target Chain 37	UniProt (SwissProt) Primary ID of Target Chain 37	UniProt (SwissProt) Secondary ID(s) of Target Chain 37	UniProt (SwissProt) Alternative ID(s) of Target Chain 37	UniProt (TrEMBL) Submitted Name of Target Chain 37	UniProt (TrEMBL) Entry Name of Target Chain 37	UniProt (TrEMBL) Primary ID of Target Chain 37	UniProt (TrEMBL) Secondary ID(s) of Target Chain 37	UniProt (TrEMBL) Alternative ID(s) of Target Chain 37	BindingDB Target Chain Sequence 38	PDB ID(s) of Target Chain 38	UniProt (SwissProt) Recommended Name of Target Chain 38	UniProt (SwissProt) Entry Name of Target Chain 38	UniProt (SwissProt) Primary ID of Target Chain 38	UniProt (SwissProt) Secondary ID(s) of Target Chain 38	UniProt (SwissProt) Alternative ID(s) of Target Chain 38	UniProt (TrEMBL) Submitted Name of Target Chain 38	UniProt (TrEMBL) Entry Name of Target Chain 38	UniProt (TrEMBL) Primary ID of Target Chain 38	UniProt (TrEMBL) Secondary ID(s) of Target Chain 38	UniProt (TrEMBL) Alternative ID(s) of Target Chain 38	BindingDB Target Chain Sequence 39	PDB ID(s) of Target Chain 39	UniProt (SwissProt) Recommended Name of Target Chain 39	UniProt (SwissProt) Entry Name of Target Chain 39	UniProt (SwissProt) Primary ID of Target Chain 39	UniProt (SwissProt) Secondary ID(s) of Target Chain 39	UniProt (SwissProt) Alternative ID(s) of Target Chain 39	UniProt (TrEMBL) Submitted Name of Target Chain 39	UniProt (TrEMBL) Entry Name of Target Chain 39	UniProt (TrEMBL) Primary ID of Target Chain 39	UniProt (TrEMBL) Secondary ID(s) of Target Chain 39	UniProt (TrEMBL) Alternative ID(s) of Target Chain 39	BindingDB Target Chain Sequence 40	PDB ID(s) of Target Chain 40	UniProt (SwissProt) Recommended Name of Target Chain 40	UniProt (SwissProt) Entry Name of Target Chain 40	UniProt (SwissProt) Primary ID of Target Chain 40	UniProt (SwissProt) Secondary ID(s) of Target Chain 40	UniProt (SwissProt) Alternative ID(s) of Target Chain 40	UniProt (TrEMBL) Submitted Name of Target Chain 40	UniProt (TrEMBL) Entry Name of Target Chain 40	UniProt (TrEMBL) Primary ID of Target Chain 40	UniProt (TrEMBL) Secondary ID(s) of Target Chain 40	UniProt (TrEMBL) Alternative ID(s) of Target Chain 40	BindingDB Target Chain Sequence 41	PDB ID(s) of Target Chain 41	UniProt (SwissProt) Recommended Name of Target Chain 41	UniProt (SwissProt) Entry Name of Target Chain 41	UniProt (SwissProt) Primary ID of Target Chain 41	UniProt (SwissProt) Secondary ID(s) of Target Chain 41	UniProt (SwissProt) Alternative ID(s) of Target Chain 41	UniProt (TrEMBL) Submitted Name of Target Chain 41	UniProt (TrEMBL) Entry Name of Target Chain 41	UniProt (TrEMBL) Primary ID of Target Chain 41	UniProt (TrEMBL) Secondary ID(s) of Target Chain 41	UniProt (TrEMBL) Alternative ID(s) of Target Chain 41	BindingDB Target Chain Sequence 42	PDB ID(s) of Target Chain 42	UniProt (SwissProt) Recommended Name of Target Chain 42	UniProt (SwissProt) Entry Name of Target Chain 42	UniProt (SwissProt) Primary ID of Target Chain 42	UniProt (SwissProt) Secondary ID(s) of Target Chain 42	UniProt (SwissProt) Alternative ID(s) of Target Chain 42	UniProt (TrEMBL) Submitted Name of Target Chain 42	UniProt (TrEMBL) Entry Name of Target Chain 42	UniProt (TrEMBL) Primary ID of Target Chain 42	UniProt (TrEMBL) Secondary ID(s) of Target Chain 42	UniProt (TrEMBL) Alternative ID(s) of Target Chain 42	BindingDB Target Chain Sequence 43	PDB ID(s) of Target Chain 43	UniProt (SwissProt) Recommended Name of Target Chain 43	UniProt (SwissProt) Entry Name of Target Chain 43	UniProt (SwissProt) Primary ID of Target Chain 43	UniProt (SwissProt) Secondary ID(s) of Target Chain 43	UniProt (SwissProt) Alternative ID(s) of Target Chain 43	UniProt (TrEMBL) Submitted Name of Target Chain 43	UniProt (TrEMBL) Entry Name of Target Chain 43	UniProt (TrEMBL) Primary ID of Target Chain 43	UniProt (TrEMBL) Secondary ID(s) of Target Chain 43	UniProt (TrEMBL) Alternative ID(s) of Target Chain 43	BindingDB Target Chain Sequence 44	PDB ID(s) of Target Chain 44	UniProt (SwissProt) Recommended Name of Target Chain 44	UniProt (SwissProt) Entry Name of Target Chain 44	UniProt (SwissProt) Primary ID of Target Chain 44	UniProt (SwissProt) Secondary ID(s) of Target Chain 44	UniProt (SwissProt) Alternative ID(s) of Target Chain 44	UniProt (TrEMBL) Submitted Name of Target Chain 44	UniProt (TrEMBL) Entry Name of Target Chain 44	UniProt (TrEMBL) Primary ID of Target Chain 44	UniProt (TrEMBL) Secondary ID(s) of Target Chain 44	UniProt (TrEMBL) Alternative ID(s) of Target Chain 44	BindingDB Target Chain Sequence 45	PDB ID(s) of Target Chain 45	UniProt (SwissProt) Recommended Name of Target Chain 45	UniProt (SwissProt) Entry Name of Target Chain 45	UniProt (SwissProt) Primary ID of Target Chain 45	UniProt (SwissProt) Secondary ID(s) of Target Chain 45	UniProt (SwissProt) Alternative ID(s) of Target Chain 45	UniProt (TrEMBL) Submitted Name of Target Chain 45	UniProt (TrEMBL) Entry Name of Target Chain 45	UniProt (TrEMBL) Primary ID of Target Chain 45	UniProt (TrEMBL) Secondary ID(s) of Target Chain 45	UniProt (TrEMBL) Alternative ID(s) of Target Chain 45	BindingDB Target Chain Sequence 46	PDB ID(s) of Target Chain 46	UniProt (SwissProt) Recommended Name of Target Chain 46	UniProt (SwissProt) Entry Name of Target Chain 46	UniProt (SwissProt) Primary ID of Target Chain 46	UniProt (SwissProt) Secondary ID(s) of Target Chain 46	UniProt (SwissProt) Alternative ID(s) of Target Chain 46	UniProt (TrEMBL) Submitted Name of Target Chain 46	UniProt (TrEMBL) Entry Name of Target Chain 46	UniProt (TrEMBL) Primary ID of Target Chain 46	UniProt (TrEMBL) Secondary ID(s) of Target Chain 46	UniProt (TrEMBL) Alternative ID(s) of Target Chain 46	BindingDB Target Chain Sequence 47	PDB ID(s) of Target Chain 47	UniProt (SwissProt) Recommended Name of Target Chain 47	UniProt (SwissProt) Entry Name of Target Chain 47	UniProt (SwissProt) Primary ID of Target Chain 47	UniProt (SwissProt) Secondary ID(s) of Target Chain 47	UniProt (SwissProt) Alternative ID(s) of Target Chain 47	UniProt (TrEMBL) Submitted Name of Target Chain 47	UniProt (TrEMBL) Entry Name of Target Chain 47	UniProt (TrEMBL) Primary ID of Target Chain 47	UniProt (TrEMBL) Secondary ID(s) of Target Chain 47	UniProt (TrEMBL) Alternative ID(s) of Target Chain 47	BindingDB Target Chain Sequence 48	PDB ID(s) of Target Chain 48	UniProt (SwissProt) Recommended Name of Target Chain 48	UniProt (SwissProt) Entry Name of Target Chain 48	UniProt (SwissProt) Primary ID of Target Chain 48	UniProt (SwissProt) Secondary ID(s) of Target Chain 48	UniProt (SwissProt) Alternative ID(s) of Target Chain 48	UniProt (TrEMBL) Submitted Name of Target Chain 48	UniProt (TrEMBL) Entry Name of Target Chain 48	UniProt (TrEMBL) Primary ID of Target Chain 48	UniProt (TrEMBL) Secondary ID(s) of Target Chain 48	UniProt (TrEMBL) Alternative ID(s) of Target Chain 48	BindingDB Target Chain Sequence 49	PDB ID(s) of Target Chain 49	UniProt (SwissProt) Recommended Name of Target Chain 49	UniProt (SwissProt) Entry Name of Target Chain 49	UniProt (SwissProt) Primary ID of Target Chain 49	UniProt (SwissProt) Secondary ID(s) of Target Chain 49	UniProt (SwissProt) Alternative ID(s) of Target Chain 49	UniProt (TrEMBL) Submitted Name of Target Chain 49	UniProt (TrEMBL) Entry Name of Target Chain 49	UniProt (TrEMBL) Primary ID of Target Chain 49	UniProt (TrEMBL) Secondary ID(s) of Target Chain 49	UniProt (TrEMBL) Alternative ID(s) of Target Chain 49	BindingDB Target Chain Sequence 50	PDB ID(s) of Target Chain 50	UniProt (SwissProt) Recommended Name of Target Chain 50	UniProt (SwissProt) Entry Name of Target Chain 50	UniProt (SwissProt) Primary ID of Target Chain 50	UniProt (SwissProt) Secondary ID(s) of Target Chain 50	UniProt (SwissProt) Alternative ID(s) of Target Chain 50	UniProt (TrEMBL) Submitted Name of Target Chain 50	UniProt (TrEMBL) Entry Name of Target Chain 50	UniProt (TrEMBL) Primary ID of Target Chain 50	UniProt (TrEMBL) Secondary ID(s) of Target Chain 50	UniProt (TrEMBL) Alternative ID(s) of Target Chain 50
124452	CC1(NS(=O)(=O)c2ccc3c4c(N5CCN(C(=O)C6CC6)CC5)ncnc4n(-c4nnc(C(F)F)s4)c3c2)CC1	InChI=1S/C25H26F2N8O3S2/c1-25(6-7-25)32-40(37,38)15-4-5-16-17(12-15)35(24-31-30-22(39-24)19(26)27)21-18(16)20(28-13-29-21)33-8-10-34(11-9-33)23(36)14-2-3-14/h4-5,12-14,19,32H,2-3,6-11H2,1H3	GYLINFGRSWKVSJ-UHFFFAOYSA-N	83458	US20250388589, Example 1	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83458	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83458&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			170380031	252658649							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124453	N#CC1(NS(=O)(=O)c2ccc3c4c(N5CCN(C(=O)C6CC6)CC5)ncnc4n(-c4nnc(C(F)F)s4)c3c2)CC1	InChI=1S/C25H23F2N9O3S2/c26-19(27)22-31-32-24(40-22)36-17-11-15(41(38,39)33-25(12-28)5-6-25)3-4-16(17)18-20(29-13-30-21(18)36)34-7-9-35(10-8-34)23(37)14-1-2-14/h3-4,11,13-14,19,33H,1-2,5-10H2	ULAUAAJBFFAWGB-UHFFFAOYSA-N	83738	N-(1-Cyanocyclopropyl)-4-(4- (cyclopropanecarbonyl)piperazin-1-yl)-9- (5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)- 9H-pyrimido[4,5-b]indole-7-sulfonamide::US20250388589, Example 2	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83738	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83738&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460737	252658920							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124454	CC(C)(C)C(=O)N1CCN(c2ncnc3c2c2ccc(S(=O)(=O)NC4(C#N)CC4)cc2n3-c2nnc(C(F)F)s2)CC1	InChI=1S/C26H27F2N9O3S2/c1-25(2,3)23(38)36-10-8-35(9-11-36)20-18-16-5-4-15(42(39,40)34-26(13-29)6-7-26)12-17(16)37(21(18)31-14-30-20)24-33-32-22(41-24)19(27)28/h4-5,12,14,19,34H,6-11H2,1-3H3	JDVIGAFSHVWGBY-UHFFFAOYSA-N	83739	N-(1-Cyanocyclopropyl)-9-(5- (difluoromethyl)-1,3,4-thiadiazol-2-yl)-4- (4-pivaloylpiperazin-1-yl)-9H- pyrimido[4,5-b]indole-7-sulfonamide::US20250388589, Example 3	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83739	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83739&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460735	252658921							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124455	CC1(C(=O)N2CCN(c3ncnc4c3c3ccc(S(=O)(=O)NC5(C#N)CC5)cc3n4-c3nnc(C(F)F)s3)CC2)CCC1	InChI=1S/C27H27F2N9O3S2/c1-26(5-2-6-26)24(39)37-11-9-36(10-12-37)21-19-17-4-3-16(43(40,41)35-27(14-30)7-8-27)13-18(17)38(22(19)32-15-31-21)25-34-33-23(42-25)20(28)29/h3-4,13,15,20,35H,2,5-12H2,1H3	PVYLOKMFQJDMMD-UHFFFAOYSA-N	83740	N-(1-Cyanocyclopropyl)-9-(5- (difluoromethyl)-1,3,4-thiadiazol-2-yl)-4- (4-(1-methylcyclobutane-1- carbonyl)piperazin-1-yl)-9H-pyrimido[4,5- b]indole-7-sulfonamide::US20250388589, Example 4	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83740	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83740&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171461009	252658922							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124456	C[C@@H]1CN(c2ncnc3c2c2ccc(S(=O)(=O)NC4(C#N)CC4)cc2n3-c2nnc(C(F)F)s2)CCN1C(=O)C1CCC1	InChI=1S/C27H27F2N9O3S2/c1-15-12-36(9-10-37(15)25(39)16-3-2-4-16)22-20-18-6-5-17(43(40,41)35-27(13-30)7-8-27)11-19(18)38(23(20)32-14-31-22)26-34-33-24(42-26)21(28)29/h5-6,11,14-16,21,35H,2-4,7-10,12H2,1H3	DCGPVQCUCXHZIA-UHFFFAOYSA-N	83741	(R)-N-(1-Cyanocyclopropyl)-4-(4- (cyclobutanecarbonyl)-3-methylpiperazin- 1-yl)-9-(5-(difluoromethyl)-1,3,4- thiadiazol-2-yl)-9H-pyrimido[4,5-b]indole- 7-sulfonamide::US20250388589, Example 5	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83741	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83741&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			170312111	252658923							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124457	CN(C)C(=O)N1CCN(c2ncnc3c2c2ccc(S(=O)(=O)NC4(C#N)CC4)cc2n3-c2nnc(C(F)F)s2)CC1	InChI=1S/C24H24F2N10O3S2/c1-33(2)23(37)35-9-7-34(8-10-35)19-17-15-4-3-14(41(38,39)32-24(12-27)5-6-24)11-16(15)36(20(17)29-13-28-19)22-31-30-21(40-22)18(25)26/h3-4,11,13,18,32H,5-10H2,1-2H3	IMJPIHLDWJYNER-UHFFFAOYSA-N	83742	4-(7-(N-(1-Cyanocyclopropyl)sulfamoyl)- 9-(5-(difluoromethyl)-1,3,4-thiadiazol-2- yl)-9H-pyrimido[4,5-b]indol-4-yl)-N,N- dimethylpiperazine-1-carboxamide::US20250388589, Example 6	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83742	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83742&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171461037	252658924							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124458	CCN(C)C(=O)N1CCN(c2ncnc3c2c2ccc(S(=O)(=O)NC4(C#N)CC4)cc2n3-c2nnc(C(F)F)s2)CC1	InChI=1S/C25H26F2N10O3S2/c1-3-34(2)24(38)36-10-8-35(9-11-36)20-18-16-5-4-15(42(39,40)33-25(13-28)6-7-25)12-17(16)37(21(18)30-14-29-20)23-32-31-22(41-23)19(26)27/h4-5,12,14,19,33H,3,6-11H2,1-2H3	KCNNCQXUFXQUCP-UHFFFAOYSA-N	83743	4-(7-(N-(1-Cyanocyclopropyl)sulfamoyl)- 9-(5-(difluoromethyl)-1,3,4-thiadiazol-2- yl)-9H-pyrimido[4,5-b]indol-4-yl)-N-ethyl- N-methylpiperazine-1-carboxamide::US20250388589, Example 7	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83743	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83743&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			170312107	252658925							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124459	N#CC1(NS(=O)(=O)c2ccc3c4c(N5CCN(C(=O)N6CCOCC6)CC5)ncnc4n(-c4nnc(C(F)F)s4)c3c2)CC1	InChI=1S/C26H26F2N10O4S2/c27-20(28)23-32-33-24(43-23)38-18-13-16(44(40,41)34-26(14-29)3-4-26)1-2-17(18)19-21(30-15-31-22(19)38)35-5-7-36(8-6-35)25(39)37-9-11-42-12-10-37/h1-2,13,15,20,34H,3-12H2	NUROPWQFQIBUMW-UHFFFAOYSA-N	83744	N-(1-Cyanocyclopropyl)-9-(5- (difluoromethyl)-1,3,4-thiadiazol-2-yl)-4- (4-(morpholine-4-carbonyl)piperazin-1-yl)- 9H-pyrimido[4,5-b]indole-7-sulfonamide::US20250388589, Example 8	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83744	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83744&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460828	252658926							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124460	CN1CCN(C(=O)N2CCN(c3ncnc4c3c3ccc(S(=O)(=O)NC5(C#N)CC5)cc3n4-c3nnc(C(F)F)s3)CC2)CC1	InChI=1S/C27H29F2N11O3S2/c1-36-6-8-38(9-7-36)26(41)39-12-10-37(11-13-39)22-20-18-3-2-17(45(42,43)35-27(15-30)4-5-27)14-19(18)40(23(20)32-16-31-22)25-34-33-24(44-25)21(28)29/h2-3,14,16,21,35H,4-13H2,1H3	RCOZQVZPFSBIAR-UHFFFAOYSA-N	83745	N-(1-Cyanocyclopropyl)-9-(5- (difluoromethyl)-1,3,4-thiadiazol-2-yl)-4- (4-(4-methylpiperazine-1- carbonyl)piperazin-1-yl)-9H-pyrimido[4,5- b]indole-7-sulfonamide::US20250388589, Example 9	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83745	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83745&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460874	252658927							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124461	CC1(C(=O)N2CCN(c3ncnc4c3c3ccc(S(=O)(=O)NC5(C#N)CC5)cc3n4-c3nnc(C(F)F)s3)CC2)CC1	InChI=1S/C26H25F2N9O3S2/c1-25(4-5-25)23(38)36-10-8-35(9-11-36)20-18-16-3-2-15(42(39,40)34-26(13-29)6-7-26)12-17(16)37(21(18)31-14-30-20)24-33-32-22(41-24)19(27)28/h2-3,12,14,19,34H,4-11H2,1H3	XLSKFBWXVCQOLD-UHFFFAOYSA-N	83747	N-(1-Cyanocyclopropyl)-9-(5- (difluoromethyl)-1,3,4-thiadiazol-2-yl)-4- (4-(1-methylcyclopropane-1- carbonyl)piperazin-1-yl)-9H-pyrimido[4,5- b]indole-7-sulfonamide::US20250388589, Example 10	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83747	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83747&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460789	252658929							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124462	CC(C)C(=O)N1CCN(c2ncnc3c2c2ccc(S(=O)(=O)NC4(C#N)CC4)cc2n3-c2nnc(C(F)F)s2)CC1	InChI=1S/C25H25F2N9O3S2/c1-14(2)23(37)35-9-7-34(8-10-35)20-18-16-4-3-15(41(38,39)33-25(12-28)5-6-25)11-17(16)36(21(18)30-13-29-20)24-32-31-22(40-24)19(26)27/h3-4,11,13-14,19,33H,5-10H2,1-2H3	FSNIZJSRZWXSQR-UHFFFAOYSA-N	83748	N-(1-Cyanocyclopropyl)-9-(5- (difluoromethyl)-1,3,4-thiadiazol-2-yl)-4- (4-isobutyrylpiperazin-1-yl)-9H- pyrimido[4,5-b]indole-7-sulfonamide::US20250388589, Example 11	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83748	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83748&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460802	252658930							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124463	N#CC1(NS(=O)(=O)c2ccc3c4c(N5CCN(C(=O)C6CCOCC6)CC5)ncnc4n(-c4nnc(C(F)F)s4)c3c2)CC1	InChI=1S/C27H27F2N9O4S2/c28-21(29)24-33-34-26(43-24)38-19-13-17(44(40,41)35-27(14-30)5-6-27)1-2-18(19)20-22(31-15-32-23(20)38)36-7-9-37(10-8-36)25(39)16-3-11-42-12-4-16/h1-2,13,15-16,21,35H,3-12H2	XHXKRTMBJKAWCC-UHFFFAOYSA-N	83749	N-(1-Cyanocyclopropyl)-9-(5- (difluoromethyl)-1,3,4-thiadiazol-2-yl)-4- (4-(tetrahydro-2H-pyran-4- carbonyl)piperazin-1-yl)-9H-pyrimido[4,5- b]indole-7-sulfonamide::US20250388589, Example 12	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83749	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83749&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171461046	252658931							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124464	N#CC1(NS(=O)(=O)c2ccc3c4c(N5CCN(C(=O)c6ccc(F)cc6)CC5)ncnc4n(-c4nnc(C(F)F)s4)c3c2)CC1	InChI=1S/C28H22F3N9O3S2/c29-17-3-1-16(2-4-17)26(41)39-11-9-38(10-12-39)23-21-19-6-5-18(45(42,43)37-28(14-32)7-8-28)13-20(19)40(24(21)34-15-33-23)27-36-35-25(44-27)22(30)31/h1-6,13,15,22,37H,7-12H2	PVPKVOOZNHDXPX-UHFFFAOYSA-N	83750	N-(1-Cyanocyclopropyl)-9-(5- (difluoromethyl)-1,3,4-thiadiazol-2-yl)-4- (4-(4-fluorobenzoyl)piperazin-1-yl)-9H- pyrimido[4,5-b]indole-7-sulfonamide::US20250388589, Example 13	Poly(ADP-ribose) glycohydrolase	Homo sapiens		 550							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83750	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83750&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460883	252658932							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124465	N#CC1(NS(=O)(=O)c2ccc3c4c(N5CCN(C(=O)c6ccccn6)CC5)ncnc4n(-c4nnc(C(F)F)s4)c3c2)CC1	InChI=1S/C27H22F2N10O3S2/c28-21(29)24-34-35-26(43-24)39-19-13-16(44(41,42)36-27(14-30)6-7-27)4-5-17(19)20-22(32-15-33-23(20)39)37-9-11-38(12-10-37)25(40)18-3-1-2-8-31-18/h1-5,8,13,15,21,36H,6-7,9-12H2	FWDZMRHESDBRBX-UHFFFAOYSA-N	83751	N-(1-Cyanocyclopropyl)-9-(5- (difluoromethyl)-1,3,4-thiadiazol-2-yl)-4- (4-picolinoylpiperazin-1-yl)-9H- pyrimido[4,5-b]indole-7-sulfonamide::US20250388589, Example 14	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83751	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83751&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			174236585	252658933							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124466	CC(C)OC(=O)N1CCN(c2ncnc3c2c2ccc(S(=O)(=O)NC4(C#N)CC4)cc2n3-c2nnc(C(F)F)s2)CC1	InChI=1S/C25H25F2N9O4S2/c1-14(2)40-24(37)35-9-7-34(8-10-35)20-18-16-4-3-15(42(38,39)33-25(12-28)5-6-25)11-17(16)36(21(18)30-13-29-20)23-32-31-22(41-23)19(26)27/h3-4,11,13-14,19,33H,5-10H2,1-2H3	SJRMXOGAWKSUPY-UHFFFAOYSA-N	83752	Isopropyl 4-(7-(N-(1- cyanocyclopropyl)sulfamoyl)-9-(5- (difluoromethyl)-1,3,4-thiadiazol-2-yl)-9H- pyrimido[4,5-b]indol-4-yl)piperazine-1- carboxylate::US20250388589, Example 15	Poly(ADP-ribose) glycohydrolase	Homo sapiens		 550							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83752	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83752&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			170312104	252658934							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124467	N#CC1(NS(=O)(=O)c2ccc3c4c(N5CCN(c6nccs6)CC5)ncnc4n(-c4nnc(C(F)F)s4)c3c2)CC1	InChI=1S/C24H20F2N10O2S3/c25-18(26)21-31-32-23(40-21)36-16-11-14(41(37,38)33-24(12-27)3-4-24)1-2-15(16)17-19(29-13-30-20(17)36)34-6-8-35(9-7-34)22-28-5-10-39-22/h1-2,5,10-11,13,18,33H,3-4,6-9H2	KLPSTMFOUJRFSG-UHFFFAOYSA-N	83753	N-(1-Cyanocyclopropyl)-9-(5- (difluoromethyl)-1,3,4-thiadiazol-2-yl)-4- (4-(thiazol-2-yl)piperazin-1-yl)-9H- pyrimido[4,5-b]indole-7-sulfonamide::US20250388589, Example 16	Poly(ADP-ribose) glycohydrolase	Homo sapiens		 550							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83753	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83753&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460731	252658935							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124468	N#CC1(NS(=O)(=O)c2ccc3c4c(N5CCN(c6ccccn6)CC5)ncnc4n(-c4nnc(C(F)F)s4)c3c2)CC1	InChI=1S/C26H22F2N10O2S2/c27-21(28)24-33-34-25(41-24)38-18-13-16(42(39,40)35-26(14-29)6-7-26)4-5-17(18)20-22(31-15-32-23(20)38)37-11-9-36(10-12-37)19-3-1-2-8-30-19/h1-5,8,13,15,21,35H,6-7,9-12H2	MESJLSCSIWSFTL-UHFFFAOYSA-N	83755	N-(1-Cyanocyclopropyl)-9-(5- (difluoromethyl)-1,3,4-thiadiazol-2-yl)-4- (4-(pyridin-2-yl)piperazin-1-yl)-9H- pyrimido[4,5-b]indole-7-sulfonamide::US20250388589, Example 17	Poly(ADP-ribose) glycohydrolase	Homo sapiens		 550							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83755	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83755&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460922	252658937							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124469	N#CC1(NS(=O)(=O)c2ccc3c4c(N5CCN(c6ncccn6)CC5)ncnc4n(-c4nnc(C(F)F)s4)c3c2)CC1	InChI=1S/C25H21F2N11O2S2/c26-19(27)22-33-34-24(41-22)38-17-12-15(42(39,40)35-25(13-28)4-5-25)2-3-16(17)18-20(31-14-32-21(18)38)36-8-10-37(11-9-36)23-29-6-1-7-30-23/h1-3,6-7,12,14,19,35H,4-5,8-11H2	GPRRLDPYIINIFZ-UHFFFAOYSA-N	83757	N-(1-Cyanocyclopropyl)-9-(5- (difluoromethyl)-1,3,4-thiadiazol-2-yl)-4- (4-(pyrimidin-2-yl)piperazin-1-yl)-9H- pyrimido[4,5-b]indole-7-sulfonamide::US20250388589, Example 18	Poly(ADP-ribose) glycohydrolase	Homo sapiens		 550							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83757	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83757&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460960	252658939							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124470	N#CC1(NS(=O)(=O)c2ccc3c4c(N5CCN(c6cccnn6)CC5)ncnc4n(-c4nnc(C(F)F)s4)c3c2)CC1	InChI=1S/C25H21F2N11O2S2/c26-20(27)23-33-34-24(41-23)38-17-12-15(42(39,40)35-25(13-28)5-6-25)3-4-16(17)19-21(29-14-30-22(19)38)37-10-8-36(9-11-37)18-2-1-7-31-32-18/h1-4,7,12,14,20,35H,5-6,8-11H2	XXFGXYIPAKYDEH-UHFFFAOYSA-N	83758	N-(1-Cyanocyclopropyl)-9-(5- (difluoromethyl)-1,3,4-thiadiazol-2-yl)-4- (4-(pyridazin-3-yl)piperazin-1-yl)-9H- pyrimido[4,5-b]indole-7-sulfonamide::US20250388589, Example 19	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83758	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83758&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460689	252658940							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124471	N#CC1(NS(=O)(=O)c2ccc3c4c(N5CCC6(CC5)COC6)ncnc4n(-c4nnc(C(F)F)s4)c3c2)CC1	InChI=1S/C24H22F2N8O3S2/c25-18(26)21-30-31-22(38-21)34-16-9-14(39(35,36)32-24(10-27)3-4-24)1-2-15(16)17-19(28-13-29-20(17)34)33-7-5-23(6-8-33)11-37-12-23/h1-2,9,13,18,32H,3-8,11-12H2	UALLPHHSEHNVAP-UHFFFAOYSA-N	83761	N-(1-Cyanocyclopropyl)-9-(5- (difluoromethyl)-1,3,4-thiadiazol-2-yl)-4- (2-oxa-7-azaspiro[3.5]nonan-7-yl)-9H- pyrimido[4,5-b]indole-7-sulfonamide::US20250388589, Example 20	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83761	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83761&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460983	252658942							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124472	C[C@@H]1CN(c2ncnc3c2c2ccc(S(=O)(=O)NC4(C#N)CC4)cc2n3-c2nnc(C(F)F)s2)CCO1	InChI=1S/C22H20F2N8O3S2/c1-12-9-31(6-7-35-12)18-16-14-3-2-13(37(33,34)30-22(10-25)4-5-22)8-15(14)32(19(16)27-11-26-18)21-29-28-20(36-21)17(23)24/h2-3,8,11-12,17,30H,4-7,9H2,1H3	IBADWFNCIQTSFO-UHFFFAOYSA-N	83762	(R)-N-(1-cyanocyclopropyl)-9-(5- (difluoromethyl)-1,3,4-thiadiazol-2-yl)-4- (2-methylmorpholino)-9H-pyrimido[4,5- b]indole-7-sulfonamide::US20250388589, Example 21	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83762	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83762&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			170312113	252658943							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124473	Cn1ccnc1N1CCN(c2ncnc3c2c2ccc(S(=O)(=O)NC4(C#N)CC4)cc2n3-c2nnc(C(F)F)s2)CC1	InChI=1S/C25H23F2N11O2S2/c1-35-7-6-29-23(35)37-10-8-36(9-11-37)20-18-16-3-2-15(42(39,40)34-25(13-28)4-5-25)12-17(16)38(21(18)31-14-30-20)24-33-32-22(41-24)19(26)27/h2-3,6-7,12,14,19,34H,4-5,8-11H2,1H3	KUOAVQHNNHAMDO-UHFFFAOYSA-N	83763	US20250388589, Example 22	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83763	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83763&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460872	252658944							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124474	CC(C)C(=O)N1CC2(C1)CN(c1ncnc3c1c1ccc(S(=O)(=O)NC4(C#N)CC4)cc1n3-c1nnc(C(F)F)s1)C2	InChI=1S/C26H25F2N9O3S2/c1-14(2)23(38)36-11-25(12-36)9-35(10-25)20-18-16-4-3-15(42(39,40)34-26(8-29)5-6-26)7-17(16)37(21(18)31-13-30-20)24-33-32-22(41-24)19(27)28/h3-4,7,13-14,19,34H,5-6,9-12H2,1-2H3	FCHNPHYHPHBIDK-UHFFFAOYSA-N	83764	N-(1-Cyanocyclopropyl)-9-[5- (difluoromethyl)-1,3,4-thiadiazol-2-yl]-4-[2- (2-methylpropanoyl)-2,6- diazaspiro[3.3]heptan-6-yl]pyrimido[4,5- b]indole-7-sulfonamide::US20250388589, Example 23	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83764	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83764&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171461014	252658945							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124475	CC(C)C(=O)N1C2CCC1CN(c1ncnc3c1c1ccc(S(=O)(=O)NC4(C#N)CC4)cc1n3-c1nnc(C(F)F)s1)C2	InChI=1S/C27H27F2N9O3S2/c1-14(2)25(39)37-15-3-4-16(37)11-36(10-15)22-20-18-6-5-17(43(40,41)35-27(12-30)7-8-27)9-19(18)38(23(20)32-13-31-22)26-34-33-24(42-26)21(28)29/h5-6,9,13-16,21,35H,3-4,7-8,10-11H2,1-2H3	UJAUOVYZPFUYIT-UHFFFAOYSA-N	83765	N-(1-Cyanocyclopropyl)-9-[5- (difluoromethyl)-1,3,4-thiadiazol-2-yl]-4-[8- (2-methylpropanoyl)-3,8- diazabicyclo[3.2.1]octan-3-yl]pyrimido[4,5- b]indole-7-sulfonamide::US20250388589, Example 24	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83765	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83765&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460772	252658946							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124476	CC(C)C(=O)N1CCCN(c2ncnc3c2c2ccc(S(=O)(=O)NC4(C#N)CC4)cc2n3-c2nnc(C(F)F)s2)CC1	InChI=1S/C26H27F2N9O3S2/c1-15(2)24(38)36-9-3-8-35(10-11-36)21-19-17-5-4-16(42(39,40)34-26(13-29)6-7-26)12-18(17)37(22(19)31-14-30-21)25-33-32-23(41-25)20(27)28/h4-5,12,14-15,20,34H,3,6-11H2,1-2H3	VHXWTGMCOUMLIQ-UHFFFAOYSA-N	83766	N-(1-Cyanocyclopropyl)-9-(5- (difluoromethyl)-1,3,4-thiadiazol-2-yl)-4-(4- isobutyryl-1,4-diazepan-1-yl)-9H- pyrimido[4,5-b]indole-7-sulfonamide::US20250388589, Example 25	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83766	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83766&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460795	252658947							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124477	N#CC1(NS(=O)(=O)c2ccc3c4c(N5CCN(C(=O)C6CC6(F)F)CC5)ncnc4n(-c4nnc(C(F)F)s4)c3c2)CC1	InChI=1S/C25H21F4N9O3S2/c26-18(27)21-33-34-23(42-21)38-16-9-13(43(40,41)35-24(11-30)3-4-24)1-2-14(16)17-19(31-12-32-20(17)38)36-5-7-37(8-6-36)22(39)15-10-25(15,28)29/h1-2,9,12,15,18,35H,3-8,10H2	VCPFAQBZGRUDSC-UHFFFAOYSA-N	83767	N-(1-Cyanocyclopropyl)-4-(4-(2,2- difluorocyclopropane-1-carbonyl)piperazin-1- yl)-9-(5-(difluoromethyl)-1,3,4-thiadiazol-2- yl)-9H-pyrimido[4,5-b]indole-7-sulfonamide::US20250388589, Example 26	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83767	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83767&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171461020	252658948							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124478	Cc1ccc(C(=O)N2CCN(c3ncnc4c3c3ccc(S(=O)(=O)NC5(C#N)CC5)cc3n4-c3nnc(C(F)F)s3)CC2)cn1	InChI=1S/C28H24F2N10O3S2/c1-16-2-3-17(13-32-16)26(41)39-10-8-38(9-11-39)23-21-19-5-4-18(45(42,43)37-28(14-31)6-7-28)12-20(19)40(24(21)34-15-33-23)27-36-35-25(44-27)22(29)30/h2-5,12-13,15,22,37H,6-11H2,1H3	GZTCDJZRPLTVHD-UHFFFAOYSA-N	83768	N-(1-Cyanocyclopropyl)-9-(5- (difluoromethyl)-1,3,4-thiadiazol-2-yl)-4-(4- (6-methylnicotinoyl)piperazin-1-yl)-9H- pyrimido[4,5-b]indole-7-sulfonamide::US20250388589, Example 27	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83768	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83768&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460783	252658949							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124479	CN(C)C(=O)N1CC2CN(c3ncnc4c3c3ccc(S(=O)(=O)NC5(C#N)CC5)cc3n4-c3nnc(C(F)F)s3)CC2C1	InChI=1S/C26H26F2N10O3S2/c1-35(2)25(39)37-10-14-8-36(9-15(14)11-37)21-19-17-4-3-16(43(40,41)34-26(12-29)5-6-26)7-18(17)38(22(19)31-13-30-21)24-33-32-23(42-24)20(27)28/h3-4,7,13-15,20,34H,5-6,8-11H2,1-2H3	UNCPBIIETIQJCZ-UHFFFAOYSA-N	83769	5-(7-(N-(1-Cyanocyclopropyl)sulfamoyl)-9- (5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-9H- pyrimido[4,5-b]indol-4-yl)-N,N- dimethylhexahydropyrrolo[3,4-c]pyrrole- 2(1H)-carboxamide::US20250388589, Example 28	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83769	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83769&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460793	252658950							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124480	C[C@@H]1CN(c2ncnc3c2c2ccc(S(=O)(=O)NC4(C#N)CC4)cc2n3-c2nnc(C(F)F)s2)C[C@H](C)N1C(=O)C1CC1	InChI=1S/C27H27F2N9O3S2/c1-14-10-36(11-15(2)37(14)25(39)16-3-4-16)22-20-18-6-5-17(43(40,41)35-27(12-30)7-8-27)9-19(18)38(23(20)32-13-31-22)26-34-33-24(42-26)21(28)29/h5-6,9,13-16,21,35H,3-4,7-8,10-11H2,1-2H3	BITFGBQRUYDHLQ-UHFFFAOYSA-N	83770	N-(1-Cyanocyclopropyl)-4-((3S,5R)-4- (cyclopropanecarbonyl)-3,5- dimethylpiperazin-1-yl)-9-(5- (difluoromethyl)-1,3,4-thiadiazol-2-yl)-9H- pyrimido[4,5-b]indole-7-sulfonamide::US20250388589, Example 29	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83770	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83770&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171461023	252658951							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124481	N#CC1(NS(=O)(=O)c2ccc3c4c(N5CCN(C(=O)C6CCC6)CC5)ncnc4n(-c4nnc(C(F)F)s4)c3c2)CC1	InChI=1S/C26H25F2N9O3S2/c27-20(28)23-32-33-25(41-23)37-18-12-16(42(39,40)34-26(13-29)6-7-26)4-5-17(18)19-21(30-14-31-22(19)37)35-8-10-36(11-9-35)24(38)15-2-1-3-15/h4-5,12,14-15,20,34H,1-3,6-11H2	BUANNGKVIFXFDB-UHFFFAOYSA-N	83771	N-(1-Cyanocyclopropyl)-4-(4- (cyclobutanecarbonyl)piperazin-1-yl)-9-(5- (difluoromethyl)-1,3,4-thiadiazol-2-yl)-9H- pyrimido[4,5-b]indole-7-sulfonamide::US20250388589, Example 30	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83771	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83771&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460900	252658952							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124482	CC(C)C(=O)N1[C@H](C)CN(c2ncnc3c2c2ccc(S(=O)(=O)NC4(C#N)CC4)cc2n3-c2nnc(C(F)F)s2)C[C@H]1C	InChI=1S/C27H29F2N9O3S2/c1-14(2)25(39)37-15(3)10-36(11-16(37)4)22-20-18-6-5-17(43(40,41)35-27(12-30)7-8-27)9-19(18)38(23(20)32-13-31-22)26-34-33-24(42-26)21(28)29/h5-6,9,13-16,21,35H,7-8,10-11H2,1-4H3	XRBHNMFAOYDLBH-UHFFFAOYSA-N	83772	N-(1-Cyanocyclopropyl)-9-(5- (difluoromethyl)-1,3,4-thiadiazol-2-yl)-4- ((3R,5R)-4-isobutyryl-3,5-dimethylpiperazin- 1-yl)-9H-pyrimido[4,5-b]indole-7- sulfonamide::US20250388589, Example 31	Poly(ADP-ribose) glycohydrolase	Homo sapiens		 550							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83772	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83772&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171461032	252658953							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124483	CC(C)C(=O)N1C[C@H]2CC[C@@H]1CN2c3ncnc6c3c5ccc(S(=O)(=O)NC4(C#N)CC4)cc5n6c7nnc(C(F)F)s7	InChI=1S/C27H27F2N9O3S2/c1-14(2)25(39)37-11-15-3-4-16(37)10-36(15)22-20-18-6-5-17(43(40,41)35-27(12-30)7-8-27)9-19(18)38(23(20)32-13-31-22)26-34-33-24(42-26)21(28)29/h5-6,9,13-16,21,35H,3-4,7-8,10-11H2,1-2H3	BYFZKQHOUVEFTQ-UHFFFAOYSA-N	83773	N-(1-Cyanocyclopropyl)-9-(5- (difluoromethyl)-1,3,4-thiadiazol-2-yl)-4- ((1R,4R)-5-isobutyryl-2,5- diazabicyclo[2.2.2]octan-2-yl)-9H- pyrimido[4,5-b]indole-7-sulfonamide::US20250388589, Example 32	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83773	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83773&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460844	252658954							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124484	CC(C)C(=O)N1C[C@@H](C)N(c2ncnc3c2c2ccc(S(=O)(=O)NC4(C#N)CC4)cc2n3-c2nnc(C(F)F)s2)C[C@@H]1C	InChI=1S/C27H29F2N9O3S2/c1-14(2)25(39)37-11-15(3)36(10-16(37)4)22-20-18-6-5-17(43(40,41)35-27(12-30)7-8-27)9-19(18)38(23(20)32-13-31-22)26-34-33-24(42-26)21(28)29/h5-6,9,13-16,21,35H,7-8,10-11H2,1-4H3	CKDPUIVPKJEXHU-UHFFFAOYSA-N	83774	N-(1-Cyanocyclopropyl)-9-(5- (difluoromethyl)-1,3,4-thiadiazol-2-yl)-4- ((2R,5S)-4-isobutyryl-2,5-dimethylpiperazin- 1-yl)-9H-pyrimido[4,5-b]indole-7- sulfonamide::US20250388589, Example 33	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83774	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83774&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460730	252658955							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124485	N#CC1(NS(=O)(=O)c2ccc3c4c(N5CCN(C(=O)C6CCOC6)CC5)ncnc4n(-c4nnc(C(F)F)s4)c3c2)CC1	InChI=1S/C26H25F2N9O4S2/c27-20(28)23-32-33-25(42-23)37-18-11-16(43(39,40)34-26(13-29)4-5-26)1-2-17(18)19-21(30-14-31-22(19)37)35-6-8-36(9-7-35)24(38)15-3-10-41-12-15/h1-2,11,14-15,20,34H,3-10,12H2	DOUHYOAPYODSTI-UHFFFAOYSA-N	83775	N-(1-Cyanocyclopropyl)-9-(5- (difluoromethyl)-1,3,4-thiadiazol-2-yl)-4-(4- (tetrahydrofuran-3-carbonyl)piperazin-1-yl)- 9H-pyrimido[4,5-b]indole-7-sulfonamide::US20250388589, Example 34	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83775	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83775&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460992	252658956							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124486	Cc1ccc(C(=O)N2CCN(c3ncnc4c3c3ccc(S(=O)(=O)NC5(C#N)CC5)cc3n4-c3nnc(C(F)F)s3)CC2)nc1	InChI=1S/C28H24F2N10O3S2/c1-16-2-5-19(32-13-16)26(41)39-10-8-38(9-11-39)23-21-18-4-3-17(45(42,43)37-28(14-31)6-7-28)12-20(18)40(24(21)34-15-33-23)27-36-35-25(44-27)22(29)30/h2-5,12-13,15,22,37H,6-11H2,1H3	IVNMEZRPTGLVFR-UHFFFAOYSA-N	83776	N-(1-Cyanocyclopropyl)-9-(5- (difluoromethyl)-1,3,4-thiadiazol-2-yl)-4-(4- (5-methylpicolinoyl)piperazin-1-yl)-9H- pyrimido[4,5-b]indole-7-sulfonamide::US20250388589, Example 35	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83776	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83776&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460858	252658957							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124487	CC1(C(=O)N2CC3CN(c4ncnc5c4c4ccc(S(=O)(=O)NC6(C#N)CC6)cc4n5-c4nnc(C(F)F)s4)CC3C2)CC1	InChI=1S/C28H27F2N9O3S2/c1-27(4-5-27)25(40)38-11-15-9-37(10-16(15)12-38)22-20-18-3-2-17(44(41,42)36-28(13-31)6-7-28)8-19(18)39(23(20)33-14-32-22)26-35-34-24(43-26)21(29)30/h2-3,8,14-16,21,36H,4-7,9-12H2,1H3	ZFOXJZFXMMATCW-UHFFFAOYSA-N	83777	N-(1-Cyanocyclopropyl)-9-(5- (difluoromethyl)-1,3,4-thiadiazol-2-yl)-4-(5- (1-methylcyclopropane-1- carbonyl)hexahydropyrrolo[3,4-c]pyrrol- 2(1H)-yl)-9H-pyrimido[4,5-b]indole-7- sulfonamide::US20250388589, Example 36	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83777	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83777&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460725	252658958							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124488	C[C@H]1CN(c2ncnc3c2c2ccc(S(=O)(=O)NC4(C#N)CC4)cc2n3-c2nnc(C(F)F)s2)CCN1C(=O)N(C)C	InChI=1S/C25H26F2N10O3S2/c1-14-11-35(8-9-36(14)24(38)34(2)3)20-18-16-5-4-15(42(39,40)33-25(12-28)6-7-25)10-17(16)37(21(18)30-13-29-20)23-32-31-22(41-23)19(26)27/h4-5,10,13-14,19,33H,6-9,11H2,1-3H3	KEIBHIQVXABBEX-UHFFFAOYSA-N	83778	(S)-4-(7-(N-(1-Cyanocyclopropyl)sulfamoyl)- 9-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)- 9H-pyrimido[4,5-b]indol-4-yl)-N,N,2- trimethylpiperazine-1-carboxamide::US20250388589, Example 37	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83778	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83778&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171461021	252658959							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124489	CC(C)C(=O)N1C[C@H](C)N(c2ncnc3c2c2ccc(S(=O)(=O)NC4(C#N)CC4)cc2n3-c2nnc(C(F)F)s2)C[C@H]1C	InChI=1S/C27H29F2N9O3S2/c1-14(2)25(39)37-11-15(3)36(10-16(37)4)22-20-18-6-5-17(43(40,41)35-27(12-30)7-8-27)9-19(18)38(23(20)32-13-31-22)26-34-33-24(42-26)21(28)29/h5-6,9,13-16,21,35H,7-8,10-11H2,1-4H3	CKDPUIVPKJEXHU-UHFFFAOYSA-N	83779	N-(1-Cyanocyclopropyl)-9-(5- (difluoromethyl)-1,3,4-thiadiazol-2-yl)-4- ((2S,5R)-4-isobutyryl-2,5-dimethylpiperazin- 1-yl)-9H-pyrimido[4,5-b]indole-7- sulfonamide::US20250388589, Example 38	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83779	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83779&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460939	252658960							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124490	N#CC1(NS(=O)(=O)c2ccc3c4c(N5C[C@@H](C)N(C(=O)CN6CCOCC6)[C@@H](C)C5)ncnc4n(-c4nnc(C(F)F)s4)c3c2)CC1	InChI=1S/C29H32F2N10O4S2/c1-17-12-39(13-18(2)40(17)22(42)14-38-7-9-45-10-8-38)25-23-20-4-3-19(47(43,44)37-29(15-32)5-6-29)11-21(20)41(26(23)34-16-33-25)28-36-35-27(46-28)24(30)31/h3-4,11,16-18,24,37H,5-10,12-14H2,1-2H3	QNSRWKWHPXHLNH-UHFFFAOYSA-N	83780	N-(1-Cyanocyclopropyl)-9-(5- (difluoromethyl)-1,3,4-thiadiazol-2-yl)-4- ((3R,5S)-3,5-dimethyl-4-(2- morpholinoacetyl)piperazin-1-yl)-9H- pyrimido[4,5-b]indole-7-sulfonamide::US20250388589, Example 39	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83780	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83780&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460905	252658961							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124491	N#CC1(NS(=O)(=O)c2ccc3c4c(N5CCN(CC6CC6)C(=O)C5)ncnc4n(-c4nnc(C(F)F)s4)c3c2)CC1	InChI=1S/C25H23F2N9O3S2/c26-20(27)23-31-32-24(40-23)36-17-9-15(41(38,39)33-25(12-28)5-6-25)3-4-16(17)19-21(29-13-30-22(19)36)35-8-7-34(18(37)11-35)10-14-1-2-14/h3-4,9,13-14,20,33H,1-2,5-8,10-11H2	GUDJBBABFGRSOW-UHFFFAOYSA-N	83781	N-(1-Cyanocyclopropyl)-4-(4- (cyclopropylmethyl)-3-oxopiperazin-1-yl)-9- (5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-9H- pyrimido[4,5-b]indole-7-sulfonamide::US20250388589, Example 40	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83781	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83781&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171461040	252658962							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124492	N#CC1(NS(=O)(=O)c2ccc3c4c(N5CCN(C(=O)N6CCCC6)CC5)ncnc4n(-c4nnc(C(F)F)s4)c3c2)CC1	InChI=1S/C26H26F2N10O3S2/c27-20(28)23-32-33-24(42-23)38-18-13-16(43(40,41)34-26(14-29)5-6-26)3-4-17(18)19-21(30-15-31-22(19)38)35-9-11-37(12-10-35)25(39)36-7-1-2-8-36/h3-4,13,15,20,34H,1-2,5-12H2	FOAUYCVJHBATES-UHFFFAOYSA-N	83782	N-(1-Cyanocyclopropyl)-9-(5- (difluoromethyl)-1,3,4-thiadiazol-2-yl)-4-(4- (pyrrolidine-1-carbonyl)piperazin-1-yl)-9H- pyrimido[4,5-b]indole-7-sulfonamide::US20250388589, Example 41	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83782	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83782&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460757	252658963							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124493	CN(CC(F)(F)F)C(=O)N6CCN(c1ncnc4c1c3ccc(S(=O)(=O)NC2(C#N)CC2)cc3n4c5nnc(C(F)F)s5)CC6	InChI=1S/C25H23F5N10O3S2/c1-37(12-25(28,29)30)23(41)39-8-6-38(7-9-39)19-17-15-3-2-14(45(42,43)36-24(11-31)4-5-24)10-16(15)40(20(17)33-13-32-19)22-35-34-21(44-22)18(26)27/h2-3,10,13,18,36H,4-9,12H2,1H3	RLHKURGOGGOXIH-UHFFFAOYSA-N	83783	4-(7-(N-(1-Cyanocyclopropyl)sulfamoyl)-9- (5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-9H- pyrimido[4,5-b]indol-4-yl)-N-methyl-N- (2,2,2-trifluoroethyl)piperazine-1- carboxamide::US20250388589, Example 42	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83783	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83783&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460868	252658964							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124494	CN(C)C(=O)c1ccc(-c2ncnc3c2c2ccc(S(=O)(=O)NC4(C#N)CC4)cc2n3-c2nnc(C(F)F)s2)cc1	InChI=1S/C26H20F2N8O3S2/c1-35(2)24(37)15-5-3-14(4-6-15)20-19-17-8-7-16(41(38,39)34-26(12-29)9-10-26)11-18(17)36(22(19)31-13-30-20)25-33-32-23(40-25)21(27)28/h3-8,11,13,21,34H,9-10H2,1-2H3	AYCIVIKKTIWHII-UHFFFAOYSA-N	83784	US20250388589, Example 43	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83784	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83784&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460936	252658965							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124495	COC1CCN(c2ncnc3c2c2ccc(S(=O)(=O)NC4(C#N)CC4)cc2n3-c2nnc(C(F)F)s2)CC1	InChI=1S/C23H22F2N8O3S2/c1-36-13-4-8-32(9-5-13)19-17-15-3-2-14(38(34,35)31-23(11-26)6-7-23)10-16(15)33(20(17)28-12-27-19)22-30-29-21(37-22)18(24)25/h2-3,10,12-13,18,31H,4-9H2,1H3	MUGVLVHIGARTAC-UHFFFAOYSA-N	83785	US20250388589, Example 44	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83785	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83785&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460857	252658966							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124496	C[C@@H]1CN(C(=O)N(C)C)[C@@H](C)CN1c1ncnc2c1c1cc(F)c(S(=O)(=O)NC3(C#N)CC3)cc1n2-c1nnc(C(F)F)s1	InChI=1S/C26H27F3N10O3S2/c1-13-10-38(25(40)36(3)4)14(2)9-37(13)21-19-15-7-16(27)18(44(41,42)35-26(11-30)5-6-26)8-17(15)39(22(19)32-12-31-21)24-34-33-23(43-24)20(28)29/h7-8,12-14,20,35H,5-6,9-10H2,1-4H3	QPVPKPAUFGFCLB-UHFFFAOYSA-N	83786	(2S,5R)-4-(7-(N-(1- Cyanocyclopropyl)sulfamoyl)-9-(5- (difluoromethyl)-1,3,4-thiadiazol-2-yl)-6- fluoro-9H-pyrimido[4,5-b]indol-4-yl)- N,N,2,5-tetramethylpiperazine-1- carboxamide::US20250388589, Example 45	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83786	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83786&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460894	252658967							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124497	C[C@H]1CN(c2ncnc3c2c2cc(F)c(S(=O)(=O)NC4(C#N)CC4)cc2n3-c2nnc(C(F)F)s2)CCN1C(=O)N(C)C	InChI=1S/C25H25F3N10O3S2/c1-13-10-36(6-7-37(13)24(39)35(2)3)20-18-14-8-15(26)17(43(40,41)34-25(11-29)4-5-25)9-16(14)38(21(18)31-12-30-20)23-33-32-22(42-23)19(27)28/h8-9,12-13,19,34H,4-7,10H2,1-3H3	LXANSHVJIYIEKN-UHFFFAOYSA-N	83787	(S)-4-(7-(N-(1- Cyanocyclopropyl)sulfamoyl)-9-(5- (difluoromethyl)-1,3,4-thiadiazol-2-yl)-6- fluoro-9H-pyrimido[4,5-b]indol-4-yl)- N,N,2-trimethylpiperazine-1-carboxamide::US20250388589, Example 46	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83787	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83787&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460769	252658968							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124498	COC1(C(F)(F)F)CCN(c2ncnc3c2c2ccc([S@SP1](=O)(=O)NC4(C#N)CC4)cc2n3-c2nnc(C(F)F)s2)CC1	InChI=1S/C24H21F5N8O3S2/c1-40-23(24(27,28)29)6-8-36(9-7-23)18-16-14-3-2-13(42(38,39)35-22(11-30)4-5-22)10-15(14)37(19(16)32-12-31-18)21-34-33-20(41-21)17(25)26/h2-3,10,12,17,35H,4-9H2,1H3	UVCCBCQTJYDCJK-UHFFFAOYSA-N	83789	N-(1-Cyanocyclopropyl)-9-(5- (difluoromethyl)-1,3,4-thiadiazol-2-yl)-4- (4-methoxy-4-(trifluoromethyl)piperidin- 1-yl)-9H-pyrimido[4,5-b]indole-7- sulfonamide::US20250388589, Example 47	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83789	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83789&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171461022	252658970							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124499	CC1(O)CCN(c2ncnc3c2c2ccc(S(=O)(=O)NC4(C#N)CC4)cc2n3-c2nnc(C(F)F)s2)CC1	InChI=1S/C23H22F2N8O3S2/c1-22(34)6-8-32(9-7-22)18-16-14-3-2-13(38(35,36)31-23(11-26)4-5-23)10-15(14)33(19(16)28-12-27-18)21-30-29-20(37-21)17(24)25/h2-3,10,12,17,31,34H,4-9H2,1H3	UEGYISANFHLETH-UHFFFAOYSA-N	83790	N-(1-Cyanocyclopropyl)-9-(5- (difluoromethyl)-1,3,4-thiadiazol-2-yl)-4- (4-hydroxy-4-methylpiperidin-1-yl)-9H- pyrimido[4,5-b]indole-7-sulfonamide::US20250388589, Example 48	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83790	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83790&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460729	242053773							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124500	N#CC1CCN(c2ncnc3c2c2ccc(S(=O)(=O)NC4(C#N)CC4)cc2n3-c2nnc(C(F)F)s2)CC1	InChI=1S/C23H19F2N9O2S2/c24-18(25)21-30-31-22(37-21)34-16-9-14(38(35,36)32-23(11-27)5-6-23)1-2-15(16)17-19(28-12-29-20(17)34)33-7-3-13(10-26)4-8-33/h1-2,9,12-13,18,32H,3-8H2	FJOYCMLYMWHMOB-UHFFFAOYSA-N	83791	N-(1-Cyanocyclopropyl)-4-(4- cyanopiperidin-1-yl)-9-(5- (difluoromethyl)-1,3,4-thiadiazol-2-yl)- 9H-pyrimido[4,5-b]indole-7-sulfonamide::US20250388589, Example 49	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83791	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83791&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			176023293	252658971							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124501	C[C@H]1CN(c2ncnc3c2c2ccc(S(=O)(=O)NC4(C#N)CC4)cc2n3-c2nnc(C(F)F)s2)CCO1	InChI=1S/C22H20F2N8O3S2/c1-12-9-31(6-7-35-12)18-16-14-3-2-13(37(33,34)30-22(10-25)4-5-22)8-15(14)32(19(16)27-11-26-18)21-29-28-20(36-21)17(23)24/h2-3,8,11-12,17,30H,4-7,9H2,1H3	IBADWFNCIQTSFO-UHFFFAOYSA-N	83792	(S)-N-(1-Cyanocyclopropyl)-9-(5- (difluoromethyl)-1,3,4-thiadiazol-2-yl)-4- (2-methylmorpholino)-9H-pyrimido[4,5- b]indole-7-sulfonamide::US20250388589, Example 50	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83792	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83792&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460777	252658972							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124502	N#CC1(NS(=O)(=O)c2ccc3c4c(N5CCC(F)CC5)ncnc4n(-c4nnc(C(F)F)s4)c3c2)CC1	InChI=1S/C22H19F3N8O2S2/c23-12-3-7-32(8-4-12)18-16-14-2-1-13(37(34,35)31-22(10-26)5-6-22)9-15(14)33(19(16)28-11-27-18)21-30-29-20(36-21)17(24)25/h1-2,9,11-12,17,31H,3-8H2	LNSNKONIEAESTN-UHFFFAOYSA-N	83793	N-(1-Cyanocyclopropyl)-9-(5- (difluoromethyl)-1,3,4-thiadiazol-2-yl)-4- (4-fluoropiperidin-1-yl)-9H-pyrimido[4,5- b]indole-7-sulfonamide::US20250388589, Example 51	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83793	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83793&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460912	252658973							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124503	N#CC1(NS(=O)(=O)c2ccc3c4c(N5CCC(F)(F)CC5)ncnc4n(-c4nnc(C(F)F)s4)c3c2)CC1	InChI=1S/C22H18F4N8O2S2/c23-16(24)19-30-31-20(37-19)34-14-9-12(38(35,36)32-21(10-27)3-4-21)1-2-13(14)15-17(28-11-29-18(15)34)33-7-5-22(25,26)6-8-33/h1-2,9,11,16,32H,3-8H2	HKVPCKZJZAZNIR-UHFFFAOYSA-N	83794	N-(1-Cyanocyclopropyl)-9-(5- (difluoromethyl)-1,3,4-thiadiazol-2-yl)-4- (4,4-difluoropiperidin-1-yl)-9H- pyrimido[4,5-b]indole-7-sulfonamide::US20250388589, Example 52	Poly(ADP-ribose) glycohydrolase	Homo sapiens		 550							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83794	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83794&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460879	252658974							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124504	N#CC1(NS(=O)(=O)c2ccc3c4c(N5CCOCC5)ncnc4n(-c4nnc(C(F)F)s4)c3c2)CC1	InChI=1S/C21H18F2N8O3S2/c22-16(23)19-27-28-20(35-19)31-14-9-12(36(32,33)29-21(10-24)3-4-21)1-2-13(14)15-17(25-11-26-18(15)31)30-5-7-34-8-6-30/h1-2,9,11,16,29H,3-8H2	BQGXCNJCVGYUIT-UHFFFAOYSA-N	83795	N-(1-Cyanocyclopropyl)-9-(5- (difluoromethyl)-1,3,4-thiadiazol-2-yl)-4- (piperazin-1-yl)-9H-pyrimido[4,5- b]indole-7-sulfonamide::US20250388589, Example 53	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83795	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83795&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460927	252658975							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124505	N#CC1(NS(=O)(=O)c2ccc3c4c(N5CC[C@@H](O)C5)ncnc4n(-c4nnc(C(F)F)s4)c3c2)CC1	InChI=1S/C21H18F2N8O3S2/c22-16(23)19-27-28-20(35-19)31-14-7-12(36(33,34)29-21(9-24)4-5-21)1-2-13(14)15-17(25-10-26-18(15)31)30-6-3-11(32)8-30/h1-2,7,10-11,16,29,32H,3-6,8H2	XRUUICQPVBXWGR-UHFFFAOYSA-N	83796	(R)-N-(1-Cyanocyclopropyl)-9-(5- (difluoromethyl)-1,3,4-thiadiazol-2-yl)-4- (3-hydroxypyrrolidin-1-yl)-9H- pyrimido[4,5-b]indole-7-sulfonamide::US20250388589, Example 54	Poly(ADP-ribose) glycohydrolase	Homo sapiens		 550							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83796	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83796&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460824	252658976							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124506	N#CC1(NS(=O)(=O)c2cc3c(cc2F)c2c(N4CCC(O)CC4)ncnc2n3-c2nnc(C(F)F)s2)CC1	InChI=1S/C22H19F3N8O3S2/c23-13-7-12-14(8-15(13)38(35,36)31-22(9-26)3-4-22)33(21-30-29-20(37-21)17(24)25)19-16(12)18(27-10-28-19)32-5-1-11(34)2-6-32/h7-8,10-11,17,31,34H,1-6H2	QKCPBYALZCJRLU-UHFFFAOYSA-N	83798	N-(1-Cyanocyclopropyl)-9-(5- (difluoromethyl)-1,3,4-thiadiazol-2-yl)-6- fluoro-4-(4-hydroxypiperidin-1-yl)-9H- pyrimido[4,5-b]indole-7-sulfonamide::US20250388589, Example 55	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83798	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83798&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460862	252658978							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124507	CN1CCN(c2ncnc3c2c2ccc(S(=O)(=O)NC4(C#N)CC4)cc2n3-c2nnc(C(F)F)s2)CC1	InChI=1S/C22H21F2N9O2S2/c1-31-6-8-32(9-7-31)18-16-14-3-2-13(37(34,35)30-22(11-25)4-5-22)10-15(14)33(19(16)27-12-26-18)21-29-28-20(36-21)17(23)24/h2-3,10,12,17,30H,4-9H2,1H3	FTZUITAQRWHMKW-UHFFFAOYSA-N	83799	N-(1-Cyanocyclopropyl)-9-(5- (difluoromethyl)-1,3,4-thiadiazol-2-yl)-4- (4-methylpiperazin-1-yl)-9H- pyrimido[4,5-b]indole-7-sulfonamide::US20250388589, Example 56	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83799	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83799&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460743	252658979							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124508	CC(C)C(=O)N1C[C@H](C)N(c2ncnc3c2c2ccc(S(=O)(=O)NC4(C#N)CC4)cc2n3-c2nnc(C(F)F)s2)C[C@@H]1C	InChI=1S/C27H29F2N9O3S2/c1-14(2)25(39)37-11-15(3)36(10-16(37)4)22-20-18-6-5-17(43(40,41)35-27(12-30)7-8-27)9-19(18)38(23(20)32-13-31-22)26-34-33-24(42-26)21(28)29/h5-6,9,13-16,21,35H,7-8,10-11H2,1-4H3	CKDPUIVPKJEXHU-UHFFFAOYSA-N	83800	N-(1-cyanocyclopropyl)-9-(5- (difluoromethyl)-1,3,4-thiadiazol-2-yl)-4- ((2S,5S)-4-isobutyryl-2,5- dimethylpiperazin-1-yl)-9H-pyrimido[4,5- b]indole-7-sulfonamide::US20250388589, Example 57	Poly(ADP-ribose) glycohydrolase	Homo sapiens		 550							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83800	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83800&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460999	252658980							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124509	C[C@@H]1CN(c2ncnc3c2c2ccc(S(=O)(=O)NC4(C#N)CC4)cc2n3-c2nnc(C(F)F)s2)C[C@H](C)N1C(=O)C1COC1	InChI=1S/C27H27F2N9O4S2/c1-14-8-36(9-15(2)37(14)25(39)16-10-42-11-16)22-20-18-4-3-17(44(40,41)35-27(12-30)5-6-27)7-19(18)38(23(20)32-13-31-22)26-34-33-24(43-26)21(28)29/h3-4,7,13-16,21,35H,5-6,8-11H2,1-2H3	OSVBFMXFHQBIDT-UHFFFAOYSA-N	83801	N-(1-Cyanocyclopropyl)-9-(5- (difluoromethyl)-1,3,4-thiadiazol-2-yl)-4- ((3S,5R)-3,5-dimethyl-4-(oxetane-3- carbonyl)piperazin-1-yl)-9H-pyrimido[4,5- b]indole-7-sulfonamide::US20250388589, Example 58	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83801	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83801&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171461056	242053774							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124510	C[C@@H]1CN(C(=O)N(C)C)[C@@H](C)CN1c1ncnc2c1c1ccc(S(=O)(=O)NC3(C#N)CC3)cc1n2-c1nnc(C(F)F)s1	InChI=1S/C26H28F2N10O3S2/c1-14-11-37(25(39)35(3)4)15(2)10-36(14)21-19-17-6-5-16(43(40,41)34-26(12-29)7-8-26)9-18(17)38(22(19)31-13-30-21)24-33-32-23(42-24)20(27)28/h5-6,9,13-15,20,34H,7-8,10-11H2,1-4H3	HFJGCXCTFYRZMC-UHFFFAOYSA-N	83802	(2S,5R)-4-(7-(N-(1- Cyanocyclopropyl)sulfamoyl)-9-(5- (difluoromethyl)-1,3,4-thiadiazol-2-yl)- 9H-pyrimido[4,5-b]indol-4-yl)-N,N,2,5- tetramethylpiperazine-1-carboxamide::US20250388589, Example 59	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83802	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83802&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171461057	252658981							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124511	CC(C)C(=O)N1CCN(c2ncnc3c2c2ccc(S(=O)(=O)NC4(C#N)CC4)cc2n3-c2nnc(C(F)F)s2)C[C@H]1C	InChI=1S/C26H27F2N9O3S2/c1-14(2)24(38)36-9-8-35(11-15(36)3)21-19-17-5-4-16(42(39,40)34-26(12-29)6-7-26)10-18(17)37(22(19)31-13-30-21)25-33-32-23(41-25)20(27)28/h4-5,10,13-15,20,34H,6-9,11H2,1-3H3	UMTZCBOEIVSINY-UHFFFAOYSA-N	83803	(R)-N-(1-cyanocyclopropyl)-9-(5- (difluoromethyl)-1,3,4-thiadiazol-2-yl)-4- (4-isobutyryl-3-methylpiperazin-1-yl)-9H- pyrimido[4,5-b]indole-7-sulfonamide::US20250388589, Example 60	Poly(ADP-ribose) glycohydrolase	Homo sapiens		 550							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83803	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83803&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171461038	252658982							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124512	CC(C)C(=O)N1CCN(c2ncnc3c2c2ccc(S(=O)(=O)NC4(C#N)CC4)cc2n3-c2nnc(C(F)F)s2)C[C@@H]1C	InChI=1S/C26H27F2N9O3S2/c1-14(2)24(38)36-9-8-35(11-15(36)3)21-19-17-5-4-16(42(39,40)34-26(12-29)6-7-26)10-18(17)37(22(19)31-13-30-21)25-33-32-23(41-25)20(27)28/h4-5,10,13-15,20,34H,6-9,11H2,1-3H3	UMTZCBOEIVSINY-UHFFFAOYSA-N	83804	(S)-N-(1-cyanocyclopropyl)-9-(5- (difluoromethyl)-1,3,4-thiadiazol-2-yl)-4- (4-isobutyryl-3-methylpiperazin-1-yl)-9H- pyrimido[4,5-b]indole-7-sulfonamide::US20250388589, Example 61	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83804	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83804&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460910	252658983							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124513	CC(C)C(=O)N1[C@H](C)CN(c2ncnc3c2c2ccc(S(=O)(=O)NC4(C#N)CC4)cc2n3-c2nnc(C(F)F)s2)C[C@@H]1C	InChI=1S/C27H29F2N9O3S2/c1-14(2)25(39)37-15(3)10-36(11-16(37)4)22-20-18-6-5-17(43(40,41)35-27(12-30)7-8-27)9-19(18)38(23(20)32-13-31-22)26-34-33-24(42-26)21(28)29/h5-6,9,13-16,21,35H,7-8,10-11H2,1-4H3	XRBHNMFAOYDLBH-UHFFFAOYSA-N	83805	N-(1-Cyanocyclopropyl)-9-(5- (difluoromethyl)-1,3,4-thiadiazol-2-yl)-4- ((3S,5R)-4-isobutyryl-3,5- dimethylpiperazin-1-yl)-9H-pyrimido[4,5- b]indole-7-sulfonamide::US20250388589, Example 62	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83805	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83805&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460740	252658984							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124514	N#CC1(NS(=O)(=O)c2ccc3c4c(N5CCN(C(=O)N6CCC6)CC5)ncnc4n(-c4nnc(C(F)F)s4)c3c2)CC1	InChI=1S/C25H24F2N10O3S2/c26-19(27)22-31-32-23(41-22)37-17-12-15(42(39,40)33-25(13-28)4-5-25)2-3-16(17)18-20(29-14-30-21(18)37)34-8-10-36(11-9-34)24(38)35-6-1-7-35/h2-3,12,14,19,33H,1,4-11H2	FDKYOYGGXURXIN-UHFFFAOYSA-N	83806	4-(4-(Azetidine-1-carbonyl)piperazin-1- yl)-N-(1-cyanocyclopropyl)-9-(5- (difluoromethyl)-1,3,4-thiadiazol-2-yl)- 9H-pyrimido[4,5-b]indole-7-sulfonamide::US20250388589, Example 63	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83806	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83806&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171461047	252658985							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124515	CC(C)C(=O)N1C[C@@H](C)N(c2ncnc3c2c2ccc(S(=O)(=O)NC4(C)CC4)cc2n3-c2nnc(C(F)F)s2)C[C@@H]1C	InChI=1S/C27H32F2N8O3S2/c1-14(2)25(38)36-12-15(3)35(11-16(36)4)22-20-18-7-6-17(42(39,40)34-27(5)8-9-27)10-19(18)37(23(20)31-13-30-22)26-33-32-24(41-26)21(28)29/h6-7,10,13-16,21,34H,8-9,11-12H2,1-5H3	APCWMKZJUNOUSV-UHFFFAOYSA-N	83809	9-(5-(Difluoromethyl)-1,3,4-thiadiazol-2- yl)-4-((2R,5S)-4-isobutyryl-2,5- dimethylpiperazin-1-yl)-N-(1- methylcyclopropyl)-9H-pyrimido[4,5- b]indole-7-sulfonamide::US20250388589, Example 64	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83809	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83809&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460714	252658988							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124516	CN1CC(C(=O)N2CCN(c3ncnc4c3c3ccc(S(=O)(=O)NC5(C#N)CC5)cc3n4-c3nnc(C(F)F)s3)CC2)C1	InChI=1S/C26H26F2N10O3S2/c1-35-11-15(12-35)24(39)37-8-6-36(7-9-37)21-19-17-3-2-16(43(40,41)34-26(13-29)4-5-26)10-18(17)38(22(19)31-14-30-21)25-33-32-23(42-25)20(27)28/h2-3,10,14-15,20,34H,4-9,11-12H2,1H3	OXUALDILFRFKKK-UHFFFAOYSA-N	83810	US20250388589, Example 65	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83810	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83810&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460687	252658989							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124517	N#CC1(NS(=O)(=O)c2ccc3c4c(N5CCN(C(=O)C6COC6)CC5)ncnc4n(-c4nnc(C(F)F)s4)c3c2)CC1	InChI=1S/C25H23F2N9O4S2/c26-19(27)22-31-32-24(41-22)36-17-9-15(42(38,39)33-25(12-28)3-4-25)1-2-16(17)18-20(29-13-30-21(18)36)34-5-7-35(8-6-34)23(37)14-10-40-11-14/h1-2,9,13-14,19,33H,3-8,10-11H2	RYACCIPVVNEMMM-UHFFFAOYSA-N	83811	N-(1-Cyanocyclopropyl)-9-(5- (difluoromethyl)-1,3,4-thiadiazol-2-yl)-4- (4-(oxetane-3-carbonyl)piperazin-1-yl)- 9H-pyrimido[4,5-b]indole-7-sulfonamide::US20250388589, Example 66	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83811	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83811&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460804	252658990							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124518	CN1CCC(C(=O)N2CCN(c3ncnc4c3c3ccc(S(=O)(=O)NC5(C#N)CC5)cc3n4-c3nnc(C(F)F)s3)CC2)C1	InChI=1S/C27H28F2N10O3S2/c1-36-7-4-16(13-36)25(40)38-10-8-37(9-11-38)22-20-18-3-2-17(44(41,42)35-27(14-30)5-6-27)12-19(18)39(23(20)32-15-31-22)26-34-33-24(43-26)21(28)29/h2-3,12,15-16,21,35H,4-11,13H2,1H3	DTSZGPJKNDQXGZ-UHFFFAOYSA-N	83812	N-(1-Cyanocyclopropyl)-9-(5- (difluoromethyl)-1,3,4-thiadiazol-2-yl)-4- (4-(1-methylpyrrolidine-3- carbonyl)piperazin-1-yl)-9H-pyrimido[4,5- b]indole-7-sulfonamide::US20250388589, Example 67	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83812	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83812&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460718	252658991							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124519	N#CC1(NS(=O)(=O)c2ccc3c4c(N5CCN(C(=O)C6(F)CCC6)CC5)ncnc4n(-c4nnc(C(F)F)s4)c3c2)CC1	InChI=1S/C26H24F3N9O3S2/c27-19(28)22-33-34-24(42-22)38-17-12-15(43(40,41)35-25(13-30)6-7-25)2-3-16(17)18-20(31-14-32-21(18)38)36-8-10-37(11-9-36)23(39)26(29)4-1-5-26/h2-3,12,14,19,35H,1,4-11H2	PTIXFLJOEZKJOX-UHFFFAOYSA-N	83813	N-(1-Cyanocyclopropyl)-9-(5- (difluoromethyl)-1,3,4-thiadiazol-2-yl)-4- (4-(1-fluorocyclobutane-1- carbonyl)piperazin-1-yl)-9H-pyrimido[4,5- b]indole-7-sulfonamide::US20250388589, Example 68	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83813	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83813&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171461062	252658992							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124520	CC(C)S(=O)N1CCN(c2ncnc3c2c2ccc(S(=O)(=O)NC4(C#N)CC4)cc2n3-c2nnc(C(F)F)s2)CC1	InChI=1S/C24H25F2N9O3S3/c1-14(2)40(36)34-9-7-33(8-10-34)20-18-16-4-3-15(41(37,38)32-24(12-27)5-6-24)11-17(16)35(21(18)29-13-28-20)23-31-30-22(39-23)19(25)26/h3-4,11,13-14,19,32H,5-10H2,1-2H3	PPQBLTYXRNUODG-UHFFFAOYSA-N	83814	US20250388589, Example 69	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83814	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83814&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460699	252658993							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124521	CC(C)(C)S(=O)N1CCN(c2ncnc3c2c2ccc(S(=O)(=O)NC4(C#N)CC4)cc2n3-c2nnc(C(F)F)s2)CC1	InChI=1S/C25H27F2N9O3S3/c1-24(2,3)41(37)35-10-8-34(9-11-35)20-18-16-5-4-15(42(38,39)33-25(13-28)6-7-25)12-17(16)36(21(18)30-14-29-20)23-32-31-22(40-23)19(26)27/h4-5,12,14,19,33H,6-11H2,1-3H3	JGTRYNILYSPONJ-UHFFFAOYSA-N	83815	US20250388589, Example 70	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83815	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83815&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460956	252658994							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124522	N#CC1(NS(=O)(=O)c2ccc3c4c(N5CC6CN(C(=O)C7COC7)CC6C5)ncnc4n(-c4nnc(C(F)F)s4)c3c2)CC1	InChI=1S/C27H25F2N9O4S2/c28-21(29)24-33-34-26(43-24)38-19-5-17(44(40,41)35-27(12-30)3-4-27)1-2-18(19)20-22(31-13-32-23(20)38)36-6-14-8-37(9-15(14)7-36)25(39)16-10-42-11-16/h1-2,5,13-16,21,35H,3-4,6-11H2	BEMQIFDTWAQDRZ-UHFFFAOYSA-N	83816	US20250388589, Example 71	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83816	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83816&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460839	252658995							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124523	C[C@H]1CN(C(=O)N(C)C)CCN1c1ncnc2c1c1ccc(S(=O)(=O)NC3(C#N)CC3)cc1n2-c1nnc(C(F)F)s1	InChI=1S/C25H26F2N10O3S2/c1-14-11-35(24(38)34(2)3)8-9-36(14)20-18-16-5-4-15(42(39,40)33-25(12-28)6-7-25)10-17(16)37(21(18)30-13-29-20)23-32-31-22(41-23)19(26)27/h4-5,10,13-14,19,33H,6-9,11H2,1-3H3	FQMBXQSOPCXOIY-UHFFFAOYSA-N	83817	US20250388589, Example 72	Poly(ADP-ribose) glycohydrolase	Homo sapiens		 550							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83817	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83817&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			170311322	252658996							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124524	C[C@@H]1CN(C(=O)N(C)C)CCN1c1ncnc2c1c1ccc(S(=O)(=O)NC3(C#N)CC3)cc1n2-c1nnc(C(F)F)s1	InChI=1S/C25H26F2N10O3S2/c1-14-11-35(24(38)34(2)3)8-9-36(14)20-18-16-5-4-15(42(39,40)33-25(12-28)6-7-25)10-17(16)37(21(18)30-13-29-20)23-32-31-22(41-23)19(26)27/h4-5,10,13-14,19,33H,6-9,11H2,1-3H3	FQMBXQSOPCXOIY-UHFFFAOYSA-N	83819	US20250388589, Example 73	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83819	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83819&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			170311388	252658998							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124525	CC(C)C(=O)N1CCC(c2ncnc3c2c2ccc(S(=O)(=O)NC4(C#N)CC4)cc2n3-c2nnc(C(F)F)s2)CC1	InChI=1S/C26H26F2N8O3S2/c1-14(2)24(37)35-9-5-15(6-10-35)20-19-17-4-3-16(41(38,39)34-26(12-29)7-8-26)11-18(17)36(22(19)31-13-30-20)25-33-32-23(40-25)21(27)28/h3-4,11,13-15,21,34H,5-10H2,1-2H3	JCBIBWKAPCHTPQ-UHFFFAOYSA-N	83821	US20250388589, Example 74	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83821	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83821&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460775	252659000							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124526	CC(C)C(=O)N1C=CC(c2ncnc3c2c2ccc(S(=O)(=O)NC4(C#N)CC4)cc2n3-c2nnc(C(F)F)s2)CC1	InChI=1S/C26H24F2N8O3S2/c1-14(2)24(37)35-9-5-15(6-10-35)20-19-17-4-3-16(41(38,39)34-26(12-29)7-8-26)11-18(17)36(22(19)31-13-30-20)25-33-32-23(40-25)21(27)28/h3-5,9,11,13-15,21,34H,6-8,10H2,1-2H3	MARUVORFEYVTNY-UHFFFAOYSA-N	83822	US20250388589, Example 75	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83822	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83822&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171461041	252659001							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124527	CC(C)C(=O)N1C=CC(c2ncnc3c2c2ccc(S(=O)(=O)NC4(C#N)CC4)cc2n3-c2nnc(C(F)F)s2)CC1	InChI=1S/C26H24F2N8O3S2/c1-14(2)24(37)35-9-5-15(6-10-35)20-19-17-4-3-16(41(38,39)34-26(12-29)7-8-26)11-18(17)36(22(19)31-13-30-20)25-33-32-23(40-25)21(27)28/h3-5,9,11,13-15,21,34H,6-8,10H2,1-2H3	MARUVORFEYVTNY-UHFFFAOYSA-N	83823	US20250388589, Example 76	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83823	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83823&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171461041	252659002							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124528	CN1CC=C(c2ncnc3c2c2ccc(S(=O)(=O)NC4(C#N)CC4)cc2n3-c2nnc(C(F)F)s2)CC1	InChI=1S/C23H20F2N8O2S2/c1-32-8-4-13(5-9-32)18-17-15-3-2-14(37(34,35)31-23(11-26)6-7-23)10-16(15)33(20(17)28-12-27-18)22-30-29-21(36-22)19(24)25/h2-4,10,12,19,31H,5-9H2,1H3	CYBXZQNKHZFVLK-UHFFFAOYSA-N	83824	US20250388589, Example 77	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83824	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83824&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460923	252659003							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124529	N#CC1(NS(=O)(=O)c2ccc3c4c(C5=CCOCC5)ncnc4n(-c4nnc(C(F)F)s4)c3c2)CC1	InChI=1S/C22H17F2N7O3S2/c23-18(24)20-28-29-21(35-20)31-15-9-13(36(32,33)30-22(10-25)5-6-22)1-2-14(15)16-17(26-11-27-19(16)31)12-3-7-34-8-4-12/h1-3,9,11,18,30H,4-8H2	VIGQPGHKXRVRBR-UHFFFAOYSA-N	83826	US20250388589, Example 78	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83826	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83826&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460892	252659005							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124530	N#CC1(NS(=O)(=O)c2ccc3c4c(C5CCOCC5)ncnc4n(-c4nnc(C(F)F)s4)c3c2)CC1	InChI=1S/C22H19F2N7O3S2/c23-18(24)20-28-29-21(35-20)31-15-9-13(36(32,33)30-22(10-25)5-6-22)1-2-14(15)16-17(26-11-27-19(16)31)12-3-7-34-8-4-12/h1-2,9,11-12,18,30H,3-8H2	JNEHKKGVBOLKEG-UHFFFAOYSA-N	83827	US20250388589, Example 79	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83827	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83827&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171461001	242053775							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124531	N#CC1(NS(=O)(=O)c2ccc3c4c(N5CCC(O)CC5)ccnc4n(-c4nnc(C(F)F)s4)c3c2)CC1	InChI=1S/C23H21F2N7O3S2/c24-19(25)21-28-29-22(36-21)32-17-11-14(37(34,35)30-23(12-26)6-7-23)1-2-15(17)18-16(3-8-27-20(18)32)31-9-4-13(33)5-10-31/h1-3,8,11,13,19,30,33H,4-7,9-10H2	XJWPZADCKVLBOW-UHFFFAOYSA-N	83828	US20250388589, Example 80	Poly(ADP-ribose) glycohydrolase	Homo sapiens		 550							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83828	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83828&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460977	252659006							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124532	CN(C)C(=O)N1CC=C(c2ncnc3c2c2cc(F)c(S(=O)(=O)NC4(C)CC4)cc2n3-c2nnc(C(F)F)s2)CC1	InChI=1S/C25H25F3N8O3S2/c1-25(6-7-25)33-41(38,39)17-11-16-14(10-15(17)26)18-19(13-4-8-35(9-5-13)24(37)34(2)3)29-12-30-21(18)36(16)23-32-31-22(40-23)20(27)28/h4,10-12,20,33H,5-9H2,1-3H3	DZXGFLQTFVJFEN-UHFFFAOYSA-N	83829	US20250388589, Example 81	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83829	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83829&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171461030	252659007							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124533	CN(C)C(=O)N1CCC(c2ncnc3c2c2cc(F)c(S(=O)(=O)NC4(C)CC4)cc2n3-c2nnc(C(F)F)s2)CC1	InChI=1S/C25H27F3N8O3S2/c1-25(6-7-25)33-41(38,39)17-11-16-14(10-15(17)26)18-19(13-4-8-35(9-5-13)24(37)34(2)3)29-12-30-21(18)36(16)23-32-31-22(40-23)20(27)28/h10-13,20,33H,4-9H2,1-3H3	APDFMBMAMJAZIC-UHFFFAOYSA-N	83830	US20250388589, Example 82	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83830	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83830&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460831	252659008							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124534	N#CC1(NS(=O)(=O)c2ccc3c4c(C5CCCCO5)ncnc4n(-c4nnc(C(F)F)s4)c3c2)CC1	InChI=1S/C22H19F2N7O3S2/c23-18(24)20-28-29-21(35-20)31-14-9-12(36(32,33)30-22(10-25)6-7-22)4-5-13(14)16-17(26-11-27-19(16)31)15-3-1-2-8-34-15/h4-5,9,11,15,18,30H,1-3,6-8H2	YCAXDMAHUJQTJM-UHFFFAOYSA-N	83831	US20250388589, Example 83	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83831	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83831&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460945	252659009							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124535	N#CC1(NS(=O)(=O)c2ccc3c4c(C5=CCC(O)CC5)ncnc4n(-c4nnc(C(F)F)s4)c3c2)CC1	InChI=1S/C23H19F2N7O3S2/c24-19(25)21-29-30-22(36-21)32-16-9-14(37(34,35)31-23(10-26)7-8-23)5-6-15(16)17-18(27-11-28-20(17)32)12-1-3-13(33)4-2-12/h1,5-6,9,11,13,19,31,33H,2-4,7-8H2	FKYYYGUONUYPLX-UHFFFAOYSA-N	83832	US20250388589, Example 84	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83832	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83832&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460957	252659010							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124536	N#CC1(NS(=O)(=O)c2ccc3c4c(C5CCC(O)CC5)ncnc4n(-c4nnc(C(F)F)s4)c3c2)CC1	InChI=1S/C23H21F2N7O3S2/c24-19(25)21-29-30-22(36-21)32-16-9-14(37(34,35)31-23(10-26)7-8-23)5-6-15(16)17-18(27-11-28-20(17)32)12-1-3-13(33)4-2-12/h5-6,9,11-13,19,31,33H,1-4,7-8H2	JXWWWPGOVXRYQV-UHFFFAOYSA-N	83834	US20250388589, Example 85	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83834	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83834&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460973	252659012							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124537	CC(C)(C)OC(=O)N1CCC(c2ncnc3c2c2ccc(S(=O)(=O)NC4(C#N)CC4)cc2n3-c2nnc(C(F)F)s2)CC1	InChI=1S/C27H28F2N8O4S2/c1-26(2,3)41-25(38)36-10-6-15(7-11-36)20-19-17-5-4-16(43(39,40)35-27(13-30)8-9-27)12-18(17)37(22(19)32-14-31-20)24-34-33-23(42-24)21(28)29/h4-5,12,14-15,21,35H,6-11H2,1-3H3	XCJXSQIFMPFTMZ-UHFFFAOYSA-N	83835	US20250388589, Example 86	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83835	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83835&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			170311294	252659013							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124538	N#CC1(NS(=O)(=O)c2ccc3c4c(C5CCNCC5)ncnc4n(-c4nnc(C(F)F)s4)c3c2)CC1	InChI=1S/C22H20F2N8O2S2/c23-18(24)20-29-30-21(35-20)32-15-9-13(36(33,34)31-22(10-25)5-6-22)1-2-14(15)16-17(27-11-28-19(16)32)12-3-7-26-8-4-12/h1-2,9,11-12,18,26,31H,3-8H2	FWWSPANAMMLQAL-UHFFFAOYSA-N	83836	US20250388589, Example 87	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83836	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83836&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460801	252659014							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124539	CN(C)C(=O)N1CCC(c2ncnc3c2c2ccc(S(=O)(=O)NC4(C#N)CC4)cc2n3-c2nnc(C(F)F)s2)CC1	InChI=1S/C25H25F2N9O3S2/c1-34(2)24(37)35-9-5-14(6-10-35)19-18-16-4-3-15(41(38,39)33-25(12-28)7-8-25)11-17(16)36(21(18)30-13-29-19)23-32-31-22(40-23)20(26)27/h3-4,11,13-14,20,33H,5-10H2,1-2H3	YWSBLUUNVJEDAY-UHFFFAOYSA-N	83837	US20250388589, Example 88	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83837	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83837&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171461015	252659015							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124540	CN(C)C(=O)N1CCC(c2ncnc3c2c2cc(F)c(S(=O)(=O)NC4(C#N)CC4)cc2n3-c2nnc(C(F)F)s2)CC1	InChI=1S/C25H24F3N9O3S2/c1-35(2)24(38)36-7-3-13(4-8-36)19-18-14-9-15(26)17(42(39,40)34-25(11-29)5-6-25)10-16(14)37(21(18)31-12-30-19)23-33-32-22(41-23)20(27)28/h9-10,12-13,20,34H,3-8H2,1-2H3	GDFQPWKDRUGANL-UHFFFAOYSA-N	83838	US20250388589, Example 89	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83838	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83838&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460717	252659016							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124541	CC(C)C(=O)N1CCC(c2ncnc3c2c2cc(F)c(S(=O)(=O)NC4(C#N)CC4)cc2n3-c2nnc(C(F)F)s2)CC1	InChI=1S/C26H25F3N8O3S2/c1-13(2)24(38)36-7-3-14(4-8-36)20-19-15-9-16(27)18(42(39,40)35-26(11-30)5-6-26)10-17(15)37(22(19)32-12-31-20)25-34-33-23(41-25)21(28)29/h9-10,12-14,21,35H,3-8H2,1-2H3	YVTWMDGMMJYPAZ-UHFFFAOYSA-N	83839	US20250388589, Example 90	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83839	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83839&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460820	252659017							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124542	CC(C)C(=O)N1CCC(c2ncnc3c2c2cc(F)c(S(=O)(=O)NC4(C#N)CC4)cc2n3C2NN=C(C(F)F)S2)CC1	InChI=1S/C26H27F3N8O3S2/c1-13(2)24(38)36-7-3-14(4-8-36)20-19-15-9-16(27)18(42(39,40)35-26(11-30)5-6-26)10-17(15)37(22(19)32-12-31-20)25-34-33-23(41-25)21(28)29/h9-10,12-14,21,25,34-35H,3-8H2,1-2H3	JWWPYDBTROUXMY-UHFFFAOYSA-N	83840	N-(1-Cyanocyclopropyl)-9-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-6-fluoro-4-(1-isobutyryl-1,2,3,6-tetrahydropyridin-4-yl)-9H-pyrimido[4,5-b]indole-7-sulfonamide::US20250388589, Example 91	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83840	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83840&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			178289673	252659018							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124543	CC(C)C(=O)N1C=CC(c2ncnc3c2c2cc(F)c(S(=O)(=O)NC4(C#N)CC4)cc2n3C2NN=C(C(F)F)S2)CC1	InChI=1S/C26H25F3N8O3S2/c1-13(2)24(38)36-7-3-14(4-8-36)20-19-15-9-16(27)18(42(39,40)35-26(11-30)5-6-26)10-17(15)37(22(19)32-12-31-20)25-34-33-23(41-25)21(28)29/h3,7,9-10,12-14,21,25,34-35H,4-6,8H2,1-2H3	LNJAJEFOVTWWQD-UHFFFAOYSA-N	83841	N-(1-Cyanocyclopropyl)-9-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-6-fluoro-4-(1-isobutyryl-1,2,3,4-tetrahydropyridin-4-yl)-9H-pyrimido[4,5-b]indole-7-sulfonamide::US20250388589, Example 92	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83841	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83841&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			178289674	242053776							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124544	CC1(NS(=O)(=O)c2ccc3c4c(C5CCNCC5)ncnc4n(-c4nnc(C(F)F)s4)c3c2)CC1	InChI=1S/C22H23F2N7O2S2/c1-22(6-7-22)30-35(32,33)13-2-3-14-15(10-13)31(21-29-28-20(34-21)18(23)24)19-16(14)17(26-11-27-19)12-4-8-25-9-5-12/h2-3,10-12,18,25,30H,4-9H2,1H3	BXWXHAHURSANRP-UHFFFAOYSA-N	83842	US20250388589, Example 93	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83842	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83842&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460727	242053777							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124545	CC1(NS(=O)(=O)c2ccc3c4c(C5CCN(C(=O)C(C)(C)O)CC5)ncnc4n(-c4nnc(C(F)F)s4)c3c2)CC1	InChI=1S/C26H29F2N7O4S2/c1-25(2,37)23(36)34-10-6-14(7-11-34)19-18-16-5-4-15(41(38,39)33-26(3)8-9-26)12-17(16)35(21(18)30-13-29-19)24-32-31-22(40-24)20(27)28/h4-5,12-14,20,33,37H,6-11H2,1-3H3	OKTRWNZOULKOTQ-UHFFFAOYSA-N	83843	US20250388589, Example 94	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83843	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83843&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460988	252659019							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124546	CO[C@H](C)C(=O)N1CCC(c2ncnc3c2c2ccc(S(=O)(=O)NC4(C)CC4)cc2n3-c2nnc(C(F)F)s2)CC1	InChI=1S/C26H29F2N7O4S2/c1-14(39-3)24(36)34-10-6-15(7-11-34)20-19-17-5-4-16(41(37,38)33-26(2)8-9-26)12-18(17)35(22(19)30-13-29-20)25-32-31-23(40-25)21(27)28/h4-5,12-15,21,33H,6-11H2,1-3H3	ILDUCRINODGTQH-UHFFFAOYSA-N	83844	US20250388589, Example 95	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83844	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83844&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			170311334	252659020							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124547	CO[C@@H](C)C(=O)N1CCC(c2ncnc3c2c2ccc(S(=O)(=O)NC4(C)CC4)cc2n3-c2nnc(C(F)F)s2)CC1	InChI=1S/C26H29F2N7O4S2/c1-14(39-3)24(36)34-10-6-15(7-11-34)20-19-17-5-4-16(41(37,38)33-26(2)8-9-26)12-18(17)35(22(19)30-13-29-20)25-32-31-23(40-25)21(27)28/h4-5,12-15,21,33H,6-11H2,1-3H3	ILDUCRINODGTQH-UHFFFAOYSA-N	83845	US20250388589, Example 96	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83845	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83845&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			170311350	252659021							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124548	CN(C)C(=O)c1ccc(-c2ncnc3c2c2ccc(S(=O)(=O)NC4(C#N)CC4)cc2n3-c2nnc(C(F)F)s2)cn1	InChI=1S/C25H19F2N9O3S2/c1-35(2)23(37)16-6-3-13(10-29-16)19-18-15-5-4-14(41(38,39)34-25(11-28)7-8-25)9-17(15)36(21(18)31-12-30-19)24-33-32-22(40-24)20(26)27/h3-6,9-10,12,20,34H,7-8H2,1-2H3	KGEKEMVQSYDRPB-UHFFFAOYSA-N	83847	US20250388589, Example 97	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83847	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83847&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460852	252659022							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124549	C[C@H]1CN(c2ncnc3c2c2ccc(S(=O)(=O)NC4(C#N)CC4)cc2n3-c2nnc(C(F)F)s2)CCN1C	InChI=1S/C23H23F2N9O2S2/c1-13-10-33(8-7-32(13)2)19-17-15-4-3-14(38(35,36)31-23(11-26)5-6-23)9-16(15)34(20(17)28-12-27-19)22-30-29-21(37-22)18(24)25/h3-4,9,12-13,18,31H,5-8,10H2,1-2H3	RNBDXHSQUDHTPK-UHFFFAOYSA-N	83850	US20250388589, Example 98	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83850	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83850&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			170311312	252659025							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124550	C[C@H]1CN(c2ncnc3c2c2ccc(S(=O)(=O)NC4(C)CC4)cc2n3-c2nnc(C(F)F)s2)CCO1	InChI=1S/C22H23F2N7O3S2/c1-12-10-30(7-8-34-12)18-16-14-4-3-13(36(32,33)29-22(2)5-6-22)9-15(14)31(19(16)26-11-25-18)21-28-27-20(35-21)17(23)24/h3-4,9,11-12,17,29H,5-8,10H2,1-2H3	XWPVPJDYAPPARF-UHFFFAOYSA-N	83851	US20250388589, Example 99	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83851	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83851&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			170311383	252659026							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124551	C[C@@H]1CN(C(=O)N(C)C)[C@@H](C)CN1c1ncnc2c1c1ccc(S(=O)(=O)NC3(C)CC3)cc1n2-c1nnc(C(F)F)s1	InChI=1S/C26H31F2N9O3S2/c1-14-12-36(25(38)34(4)5)15(2)11-35(14)21-19-17-7-6-16(42(39,40)33-26(3)8-9-26)10-18(17)37(22(19)30-13-29-21)24-32-31-23(41-24)20(27)28/h6-7,10,13-15,20,33H,8-9,11-12H2,1-5H3	FCIPDHFTOHSSCY-UHFFFAOYSA-N	83854	US20250388589, Example 100	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83854	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83854&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460806	252659029							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124552	C[C@H]1CN(c2ncnc3c2c2ccc(S(=O)(=O)NC4(C)CC4)cc2n3-c2nnc(C(F)F)s2)CCN1C(=O)N(C)C	InChI=1S/C25H29F2N9O3S2/c1-14-12-34(9-10-35(14)24(37)33(3)4)20-18-16-6-5-15(41(38,39)32-25(2)7-8-25)11-17(16)36(21(18)29-13-28-20)23-31-30-22(40-23)19(26)27/h5-6,11,13-14,19,32H,7-10,12H2,1-4H3	NMUUCXUMWRQHJF-UHFFFAOYSA-N	83855	US20250388589, Example 101	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83855	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83855&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			170311363	252659030							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124553	C[C@H]1CN(c2ncnc3c2c2cc(F)c(S(=O)(=O)NC4(C)CC4)cc2n3-c2nnc(C(F)F)s2)CCN1C(=O)N(C)C	InChI=1S/C25H28F3N9O3S2/c1-13-11-35(7-8-36(13)24(38)34(3)4)20-18-14-9-15(26)17(42(39,40)33-25(2)5-6-25)10-16(14)37(21(18)30-12-29-20)23-32-31-22(41-23)19(27)28/h9-10,12-13,19,33H,5-8,11H2,1-4H3	LANYGQJXCFMEQS-UHFFFAOYSA-N	83857	US20250388589, Example 102	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83857	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83857&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			170311378	242053780							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124554	CN(C)C(=O)N1CC=C(c2ncnc3c2c2cc(F)c(S(=O)(=O)NC4(C)CC4)cc2n3-c2nnc(C(F)F)s2)CC1	InChI=1S/C25H25F3N8O3S2/c1-25(6-7-25)33-41(38,39)17-11-16-14(10-15(17)26)18-19(13-4-8-35(9-5-13)24(37)34(2)3)29-12-30-21(18)36(16)23-32-31-22(40-23)20(27)28/h4,10-12,20,33H,5-9H2,1-3H3	DZXGFLQTFVJFEN-UHFFFAOYSA-N	83858	US20250388589, Example 103	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83858	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83858&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171461030	252659031							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124555	CN1CCC[C@@H]1C(=O)N1CCC(c2ncnc3c2c2ccc(S(=O)(=O)NC4(C#N)CC4)cc2n3-c2nnc(C(F)F)s2)CC1	InChI=1S/C28H29F2N9O3S2/c1-37-10-2-3-19(37)26(40)38-11-6-16(7-12-38)22-21-18-5-4-17(44(41,42)36-28(14-31)8-9-28)13-20(18)39(24(21)33-15-32-22)27-35-34-25(43-27)23(29)30/h4-5,13,15-16,19,23,36H,2-3,6-12H2,1H3	LGMKYGSRWWZHMR-UHFFFAOYSA-N	83859	US20250388589, Example 104	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83859	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83859&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171461034	252659032							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124556	CC(=O)N1CCC(c2ncnc3c2c2ccc(S(=O)(=O)NC4(C#N)CC4)cc2n3-c2nnc(C(F)F)s2)CC1	InChI=1S/C24H22F2N8O3S2/c1-13(35)33-8-4-14(5-9-33)19-18-16-3-2-15(39(36,37)32-24(11-27)6-7-24)10-17(16)34(21(18)29-12-28-19)23-31-30-22(38-23)20(25)26/h2-3,10,12,14,20,32H,4-9H2,1H3	SRBNKICBSRIIEG-UHFFFAOYSA-N	83861	4-(1-acetylpiperidin- 4-yl)-N-(1- cyanocyclopropyl)-9- (5-(difluoromethyl)- 1,3,4-thiadiazol-2-yl)- 9H-pyrimido[4,5- b]indole-7-sulfonamide::US20250388589, Example 105	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83861	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83861&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460908	252659034							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124557	C[C@H](O)C(=O)N1CCC(c2ncnc3c2c2ccc(S(=O)(=O)NC4(C#N)CC4)cc2n3-c2nnc(C(F)F)s2)CC1	InChI=1S/C25H24F2N8O4S2/c1-13(36)23(37)34-8-4-14(5-9-34)19-18-16-3-2-15(41(38,39)33-25(11-28)6-7-25)10-17(16)35(21(18)30-12-29-19)24-32-31-22(40-24)20(26)27/h2-3,10,12-14,20,33,36H,4-9H2,1H3	HREVPMBZGQBUNM-UHFFFAOYSA-N	83862	(S)-N-(1- Cyanocyclopropyl)-9-(5- (difluoromethyl)-1,3,4- thiadiazol-2-yl)-4-(1- (2-hydroxypropanoyl) piperidin-4-yl)-9H- pyrimido[4,5-b]indole- 7-sulfonamide::US20250388589, Example 106	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83862	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83862&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460756	252659035							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124558	C[C@@H](O)C(=O)N1CCC(c2ncnc3c2c2ccc(S(=O)(=O)NC4(C#N)CC4)cc2n3-c2nnc(C(F)F)s2)CC1	InChI=1S/C25H24F2N8O4S2/c1-13(36)23(37)34-8-4-14(5-9-34)19-18-16-3-2-15(41(38,39)33-25(11-28)6-7-25)10-17(16)35(21(18)30-12-29-19)24-32-31-22(40-24)20(26)27/h2-3,10,12-14,20,33,36H,4-9H2,1H3	HREVPMBZGQBUNM-UHFFFAOYSA-N	83863	(R)-N-(1- Cyanocyclopropyl)-9-(5- (difluoromethyl)-1,3,4- thiadiazol-2-yl)-4-(1- (2-hydroxypropanoyl) piperidin-4-yl)-9H- pyrimido[4,5-b]indole- 7-sulfonamide::US20250388589, Example 107	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83863	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83863&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460797	252659036							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124559	CO[C@@H](C)C(=O)N1CCC(c2ncnc3c2c2ccc(S(=O)(=O)NC4(C#N)CC4)cc2n3-c2nnc(C(F)F)s2)CC1	InChI=1S/C26H26F2N8O4S2/c1-14(40-2)24(37)35-9-5-15(6-10-35)20-19-17-4-3-16(42(38,39)34-26(12-29)7-8-26)11-18(17)36(22(19)31-13-30-20)25-33-32-23(41-25)21(27)28/h3-4,11,13-15,21,34H,5-10H2,1-2H3	UEINLGIBGYXSKK-UHFFFAOYSA-N	83864	(S)-N-(1- Cyanocyclopropyl)-9-(5- (difluoromethyl)-1,3,4- thiadiazol-2-yl)-4-(1- (2-methoxypropanoyl) piperidin-4-yl)-9H- pyrimido[4,5-b]indole- 7-sulfonamide::US20250388589, Example 108	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83864	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83864&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460697	252659037							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124560	CO[C@H](C)C(=O)N1CCC(c2ncnc3c2c2ccc(S(=O)(=O)NC4(C#N)CC4)cc2n3-c2nnc(C(F)F)s2)CC1	InChI=1S/C26H26F2N8O4S2/c1-14(40-2)24(37)35-9-5-15(6-10-35)20-19-17-4-3-16(42(38,39)34-26(12-29)7-8-26)11-18(17)36(22(19)31-13-30-20)25-33-32-23(41-25)21(27)28/h3-4,11,13-15,21,34H,5-10H2,1-2H3	UEINLGIBGYXSKK-UHFFFAOYSA-N	83865	(R)-N-(1- cyanocyclopropyl)-9-(5- (difluoromethyl)-1,3,4- thiadiazol-2-yl)-4-(1- (2-methoxypropanoyl) piperidin-4-yl)-9H- pyrimido[4,5-b]indole- 7-sulfonamide::US20250388589, Example 109	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83865	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83865&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460822	252659038							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124561	N#CC1(NS(=O)(=O)c2ccc3c4c(C5CCN(C(=O)[C@H]6CCCO6)CC5)ncnc4n(-c4nnc(C(F)F)s4)c3c2)CC1	InChI=1S/C27H26F2N8O4S2/c28-22(29)24-33-34-26(42-24)37-18-12-16(43(39,40)35-27(13-30)7-8-27)3-4-17(18)20-21(31-14-32-23(20)37)15-5-9-36(10-6-15)25(38)19-2-1-11-41-19/h3-4,12,14-15,19,22,35H,1-2,5-11H2	LYTRBRVHHWJBMI-UHFFFAOYSA-N	83866	(R)-N-(1- cyanocyclopropyl)-9-(5- (difluoromethyl)-1,3,4- thiadiazol-2-yl)-4-(1- (tetrahydrofuran-2-carbonyl) piperidin-4-yl)- 9H-pyrimido[4,5-b]indole- 7-sulfonamide::US20250388589, Example 110	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83866	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83866&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171461044	252659039							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124562	N#CC1(NS(=O)(=O)c2ccc3c4c(C5CCN(C(=O)[C@@H]6CCCO6)CC5)ncnc4n(-c4nnc(C(F)F)s4)c3c2)CC1	InChI=1S/C27H26F2N8O4S2/c28-22(29)24-33-34-26(42-24)37-18-12-16(43(39,40)35-27(13-30)7-8-27)3-4-17(18)20-21(31-14-32-23(20)37)15-5-9-36(10-6-15)25(38)19-2-1-11-41-19/h3-4,12,14-15,19,22,35H,1-2,5-11H2	LYTRBRVHHWJBMI-UHFFFAOYSA-N	83867	(S)-N-(1- cyanocyclopropyl)-9-(5- (difluoromethyl)-1,3,4- thiadiazol-2-yl)-4-(1- (tetrahydrofuran-2-carbonyl) piperidin-4-yl)- 9H-pyrimido[4,5-b]indole- 7-sulfonamide::US20250388589, Example 111	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83867	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83867&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460746	252659040							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124563	CN1CCC[C@H]1C(=O)N1CCC(c2ncnc3c2c2ccc(S(=O)(=O)NC4(C#N)CC4)cc2n3-c2nnc(C(F)F)s2)CC1	InChI=1S/C28H29F2N9O3S2/c1-37-10-2-3-19(37)26(40)38-11-6-16(7-12-38)22-21-18-5-4-17(44(41,42)36-28(14-31)8-9-28)13-20(18)39(24(21)33-15-32-22)27-35-34-25(43-27)23(29)30/h4-5,13,15-16,19,23,36H,2-3,6-12H2,1H3	LGMKYGSRWWZHMR-UHFFFAOYSA-N	83868	N-(1- cyanocyclopropyl)-9-(5- (difluoromethyl)-1,3,4- thiadiazol-2-yl)-4-(1- (methyl-L-prolyl) piperidin-4-yl)-9H- pyrimido[4,5-b]indole- 7-sulfonamide::US20250388589, Example 112	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83868	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83868&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460771	252659041							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124564	N#CC1(NS(=O)(=O)c2ccc3c4c(C5CCN(C(=O)C6COC6)CC5)ncnc4n(-c4nnc(C(F)F)s4)c3c2)CC1	InChI=1S/C26H24F2N8O4S2/c27-21(28)23-32-33-25(41-23)36-18-9-16(42(38,39)34-26(12-29)5-6-26)1-2-17(18)19-20(30-13-31-22(19)36)14-3-7-35(8-4-14)24(37)15-10-40-11-15/h1-2,9,13-15,21,34H,3-8,10-11H2	QQWAFMYHWIKSLD-UHFFFAOYSA-N	83869	N-(1- cyanocyclopropyl)-9-(5- (difluoromethyl)-1,3,4- thiadiazol-2-yl)-4-(1- (oxetane-3-carbonyl) piperidin-4-yl)-9H- pyrimido[4,5-b]indole- 7-sulfonamide::US20250388589, Example 113	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83869	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83869&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460709	252659042							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124565	N#CC1(NS(=O)(=O)c2ccc3c4c(C5CCN(C(=O)C6(O)CC6)CC5)ncnc4n(-c4nnc(C(F)F)s4)c3c2)CC1	InChI=1S/C26H24F2N8O4S2/c27-20(28)22-32-33-24(41-22)36-17-11-15(42(39,40)34-25(12-29)5-6-25)1-2-16(17)18-19(30-13-31-21(18)36)14-3-9-35(10-4-14)23(37)26(38)7-8-26/h1-2,11,13-14,20,34,38H,3-10H2	IXHFRDBCOVPFFQ-UHFFFAOYSA-N	83870	N-(1- cyanocyclopropyl)-9-(5- (difluoromethyl)-1,3,4- thiadiazol-2-yl)-4-(1- (1-hydroxycyclopropane-1- carbonyl)piperidin-4- yl)-9H-pyrimido[4,5- b]indole-7-sulfonamide::US20250388589, Example 114	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83870	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83870&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460800	252659043							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124566	N#CC1(NS(=O)(=O)c2ccc3c4c(C5CCN(C(=O)[C@H]6CCOC6)CC5)ncnc4n(-c4nnc(C(F)F)s4)c3c2)CC1	InChI=1S/C27H26F2N8O4S2/c28-22(29)24-33-34-26(42-24)37-19-11-17(43(39,40)35-27(13-30)6-7-27)1-2-18(19)20-21(31-14-32-23(20)37)15-3-8-36(9-4-15)25(38)16-5-10-41-12-16/h1-2,11,14-16,22,35H,3-10,12H2	NRBMBLOSOJBPFD-UHFFFAOYSA-N	83872	(S)-N-(1- cyanocyclopropyl)-9-(5- (difluoromethyl)-1,3,4- thiadiazol-2-yl)-4-(1- (tetrahydrofuran-3-carbonyl) piperidin-4-yl)- 9H-pyrimido[4,5-b]indole- 7-sulfonamide::US20250388589, Example 115	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83872	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83872&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171461039	252659045							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124567	N#CC1(NS(=O)(=O)c2ccc3c4c(C5CCN(C(=O)[C@@H]6CCOC6)CC5)ncnc4n(-c4nnc(C(F)F)s4)c3c2)CC1	InChI=1S/C27H26F2N8O4S2/c28-22(29)24-33-34-26(42-24)37-19-11-17(43(39,40)35-27(13-30)6-7-27)1-2-18(19)20-21(31-14-32-23(20)37)15-3-8-36(9-4-15)25(38)16-5-10-41-12-16/h1-2,11,14-16,22,35H,3-10,12H2	NRBMBLOSOJBPFD-UHFFFAOYSA-N	83874	(R)-N-(1- cyanocyclopropyl)-9-(5- (difluoromethyl)-1,3,4- thiadiazol-2-yl)-4-(1- (tetrahydrofuran-3-carbonyl) piperidin-4-yl)- 9H-pyrimido[4,5-b]indole- 7-sulfonamide::US20250388589, Example 116	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83874	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83874&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460972	252659047							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124568	COCC(=O)N1CCC(c2ncnc3c2c2ccc(S(=O)(=O)NC4(C#N)CC4)cc2n3-c2nnc(C(F)F)s2)CC1	InChI=1S/C25H24F2N8O4S2/c1-39-11-18(36)34-8-4-14(5-9-34)20-19-16-3-2-15(41(37,38)33-25(12-28)6-7-25)10-17(16)35(22(19)30-13-29-20)24-32-31-23(40-24)21(26)27/h2-3,10,13-14,21,33H,4-9,11H2,1H3	CQKZWSIPVMKHNU-UHFFFAOYSA-N	84436	N-(1- cyanocyclopropyl)-9-(5- (difluoromethyl)-1,3,4- thiadiazol-2-yl)-4-(1- (2-methoxyacetyl) piperidin-4-yl)-9H- pyrimido[4,5-b]indole- 7-sulfonamide::US20250388589, Example 117	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=84436	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=84436&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171461017	252659506							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124569	CC(C)(O)C(=O)N1CCC(c2ncnc3c2c2ccc(S(=O)(=O)NC4(C#N)CC4)cc2n3-c2nnc(C(F)F)s2)CC1	InChI=1S/C26H26F2N8O4S2/c1-25(2,38)23(37)35-9-5-14(6-10-35)19-18-16-4-3-15(42(39,40)34-26(12-29)7-8-26)11-17(16)36(21(18)31-13-30-19)24-33-32-22(41-24)20(27)28/h3-4,11,13-14,20,34,38H,5-10H2,1-2H3	MEEUDYMVJMSFKE-UHFFFAOYSA-N	87252	N-(1- cyanocyclopropyl)-9-(5- (difluoromethyl)-1,3,4- thiadiazol-2-yl)-4-(1- (2-hydroxy-2-methylpropanoyl) piperidin-4- yl)-9H-pyrimido[4,5-b]indole- 7-sulfonamide::US20250388589, Example 118	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=87252	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=87252&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460720	252659688							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124570	COC(C)(C)C(=O)N1CCC(c2ncnc3c2c2ccc(S(=O)(=O)NC4(C#N)CC4)cc2n3-c2nnc(C(F)F)s2)CC1	InChI=1S/C27H28F2N8O4S2/c1-26(2,41-3)24(38)36-10-6-15(7-11-36)20-19-17-5-4-16(43(39,40)35-27(13-30)8-9-27)12-18(17)37(22(19)32-14-31-20)25-34-33-23(42-25)21(28)29/h4-5,12,14-15,21,35H,6-11H2,1-3H3	NQPWVOAPGRGJLD-UHFFFAOYSA-N	87254	N-(1- cyanocyclopropyl)-9-(5- (difluoromethyl)-1,3,4- thiadiazol-2-yl)-4-(1- (2-methoxy-2-methylpropanoyl) piperidin-4- yl)-9H-pyrimido[4,5-b]indole- 7-sulfonamide::US20250388589, Example 119	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=87254	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=87254&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460855	252659689							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124571	CCC(=O)N1CCC(c2ncnc3c2c2ccc(S(=O)(=O)NC4(C#N)CC4)cc2n3-c2nnc(C(F)F)s2)CC1	InChI=1S/C25H24F2N8O3S2/c1-2-18(36)34-9-5-14(6-10-34)20-19-16-4-3-15(40(37,38)33-25(12-28)7-8-25)11-17(16)35(22(19)30-13-29-20)24-32-31-23(39-24)21(26)27/h3-4,11,13-14,21,33H,2,5-10H2,1H3	COYFBUUPOOWLIV-UHFFFAOYSA-N	87255	US20250388589, Example 120	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=87255	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=87255&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460811	252659690							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124572	CS(=O)(=O)N1CCC(c2ncnc3c2c2ccc(S(=O)(=O)NC4(C#N)CC4)cc2n3-c2nnc(C(F)F)s2)CC1	InChI=1S/C23H22F2N8O4S3/c1-39(34,35)32-8-4-13(5-9-32)18-17-15-3-2-14(40(36,37)31-23(11-26)6-7-23)10-16(15)33(20(17)28-12-27-18)22-30-29-21(38-22)19(24)25/h2-3,10,12-13,19,31H,4-9H2,1H3	WJRXFTMNHULCQA-UHFFFAOYSA-N	87256	US20250388589, Example 121	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=87256	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=87256&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171461036	252659691							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124573	CCS(=O)(=O)N1CCC(c2ncnc3c2c2ccc(S(=O)(=O)NC4(C#N)CC4)cc2n3-c2nnc(C(F)F)s2)CC1	InChI=1S/C24H24F2N8O4S3/c1-2-40(35,36)33-9-5-14(6-10-33)19-18-16-4-3-15(41(37,38)32-24(12-27)7-8-24)11-17(16)34(21(18)29-13-28-19)23-31-30-22(39-23)20(25)26/h3-4,11,13-14,20,32H,2,5-10H2,1H3	CNIJBTYGVXYLFB-UHFFFAOYSA-N	87257	US20250388589, Example 122	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=87257	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=87257&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460808	252659692							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124574	CC(C)S(=O)(=O)N1CCC(c2ncnc3c2c2ccc(S(=O)(=O)NC4(C#N)CC4)cc2n3-c2nnc(C(F)F)s2)CC1	InChI=1S/C25H26F2N8O4S3/c1-14(2)42(38,39)34-9-5-15(6-10-34)20-19-17-4-3-16(41(36,37)33-25(12-28)7-8-25)11-18(17)35(22(19)30-13-29-20)24-32-31-23(40-24)21(26)27/h3-4,11,13-15,21,33H,5-10H2,1-2H3	NUFIVXYLNFVSCL-UHFFFAOYSA-N	87258	US20250388589, Example 123	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=87258	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=87258&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460734	252659693							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124575	N#CC1(NS(=O)(=O)c2ccc3c4c(C5CCN(C(=O)[C@@H]6CCCN6)CC5)ncnc4n(-c4nnc(C(F)F)s4)c3c2)CC1	InChI=1S/C27H27F2N9O3S2/c28-22(29)24-34-35-26(42-24)38-19-12-16(43(40,41)36-27(13-30)7-8-27)3-4-17(19)20-21(32-14-33-23(20)38)15-5-10-37(11-6-15)25(39)18-2-1-9-31-18/h3-4,12,14-15,18,22,31,36H,1-2,5-11H2	UJQHLLKHIZLDQM-UHFFFAOYSA-N	87259	US20250388589, Example 124	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=87259	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=87259&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			170311356	252659694							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124576	N#CC1(NS(=O)(=O)c2ccc3c4c(C5CCN(C(=O)[C@H]6CCCN6)CC5)ncnc4n(-c4nnc(C(F)F)s4)c3c2)CC1	InChI=1S/C27H27F2N9O3S2/c28-22(29)24-34-35-26(42-24)38-19-12-16(43(40,41)36-27(13-30)7-8-27)3-4-17(19)20-21(32-14-33-23(20)38)15-5-10-37(11-6-15)25(39)18-2-1-9-31-18/h3-4,12,14-15,18,22,31,36H,1-2,5-11H2	UJQHLLKHIZLDQM-UHFFFAOYSA-N	87260	(R)-N-(1- cyanocyclopropyl)-9-(5- (difluoromethyl)-1,3,4- thiadiazol-2-yl)-4-(1- prolylpiperidin-4-yl)- 9H-pyrimido[4,5- b]indole-7-sulfonamide::US20250388589, Example 125	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=87260	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=87260&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460895	252659695							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124577	CC(C)(N)C(=O)N1CCC(c2ncnc3c2c2ccc(S(=O)(=O)NC4(C#N)CC4)cc2n3-c2nnc(C(F)F)s2)CC1	InChI=1S/C26H27F2N9O3S2/c1-25(2,30)23(38)36-9-5-14(6-10-36)19-18-16-4-3-15(42(39,40)35-26(12-29)7-8-26)11-17(16)37(21(18)32-13-31-19)24-34-33-22(41-24)20(27)28/h3-4,11,13-14,20,35H,5-10,30H2,1-2H3	TZLXKVOOIVFSTH-UHFFFAOYSA-N	87261	4-(1-(2-Amino-2- methylpropanoyl) piperidin- 4-yl)-N-(1- cyanocyclopropyl)-9-(5- (difluoromethyl)-1,3,4- thiadiazol-2-yl)-9H- pyrimido[4,5-b]indole- 7-sulfonamide::US20250388589, Example 126	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=87261	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=87261&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460694	252659696							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124578	C[C@@H](N)C(=O)N1CCC(c2ncnc3c2c2ccc(S(=O)(=O)NC4(C#N)CC4)cc2n3-c2nnc(C(F)F)s2)CC1	InChI=1S/C25H25F2N9O3S2/c1-13(29)23(37)35-8-4-14(5-9-35)19-18-16-3-2-15(41(38,39)34-25(11-28)6-7-25)10-17(16)36(21(18)31-12-30-19)24-33-32-22(40-24)20(26)27/h2-3,10,12-14,20,34H,4-9,29H2,1H3	CSOOLUSCOVMTKO-UHFFFAOYSA-N	87262	4-(1-(D-Alanyl) piperidin-4-yl)-N-(1- cyanocyclopropyl)-9- (5-(difluoromethyl)- 1,3,4-thiadiazol-2-yl)- 9H-pyrimido[4,5- b]indole-7-sulfonamide::US20250388589, Example 127	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=87262	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=87262&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460685	252659697							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124579	C[C@H](N)C(=O)N1CCC(c2ncnc3c2c2ccc(S(=O)(=O)NC4(C#N)CC4)cc2n3-c2nnc(C(F)F)s2)CC1	InChI=1S/C25H25F2N9O3S2/c1-13(29)23(37)35-8-4-14(5-9-35)19-18-16-3-2-15(41(38,39)34-25(11-28)6-7-25)10-17(16)36(21(18)31-12-30-19)24-33-32-22(40-24)20(26)27/h2-3,10,12-14,20,34H,4-9,29H2,1H3	CSOOLUSCOVMTKO-UHFFFAOYSA-N	87263	4-(1-(L-alanyl) piperidin-4-yl)-N-(1- cyanocyclopropyl)-9- (5-(difluoromethyl)- 1,3,4-thiadiazol-2-yl)- 9H-pyrimido[4,5- b]indole-7-sulfonamide::US20250388589, Example 128	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=87263	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=87263&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460963	252659698							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124580	N#CC1(NS(=O)(=O)c2ccc3c4c(C5CCN(C(=O)N6CC[C@@H](O)C6)CC5)ncnc4n(-c4nnc(C(F)F)s4)c3c2)CC1	InChI=1S/C27H27F2N9O4S2/c28-22(29)24-33-34-25(43-24)38-19-11-17(44(41,42)35-27(13-30)6-7-27)1-2-18(19)20-21(31-14-32-23(20)38)15-3-8-36(9-4-15)26(40)37-10-5-16(39)12-37/h1-2,11,14-16,22,35,39H,3-10,12H2	XLGIAZNUSQFPFD-UHFFFAOYSA-N	87264	US20250388589, Example 129	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=87264	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=87264&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			170311359	252659699							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124581	N#CC1(NS(=O)(=O)c2ccc3c4c(C5CCN(C(=O)N6CC[C@H](O)C6)CC5)ncnc4n(-c4nnc(C(F)F)s4)c3c2)CC1	InChI=1S/C27H27F2N9O4S2/c28-22(29)24-33-34-25(43-24)38-19-11-17(44(41,42)35-27(13-30)6-7-27)1-2-18(19)20-21(31-14-32-23(20)38)15-3-8-36(9-4-15)26(40)37-10-5-16(39)12-37/h1-2,11,14-16,22,35,39H,3-10,12H2	XLGIAZNUSQFPFD-UHFFFAOYSA-N	87266	US20250388589, Example 130	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=87266	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=87266&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			170311395	252659700							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124582	CC1(NS(=O)(=O)c2ccc3c4c(C5CCN(C(=O)N6CC[C@H](O)C6)CC5)ncnc4n(-c4nnc(C(F)F)s4)c3c2)CC1	InChI=1S/C27H30F2N8O4S2/c1-27(7-8-27)34-43(40,41)17-2-3-18-19(12-17)37(25-33-32-24(42-25)22(28)29)23-20(18)21(30-14-31-23)15-4-9-35(10-5-15)26(39)36-11-6-16(38)13-36/h2-3,12,14-16,22,34,38H,4-11,13H2,1H3	DJWWULBFFOLLNM-UHFFFAOYSA-N	87267	US20250388589, Example 131	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=87267	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=87267&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			170311325	252659701							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124583	CC1(NS(=O)(=O)c2ccc3c4c(C5CCN(C(=O)N6CC[C@@H](O)C6)CC5)ncnc4n(-c4nnc(C(F)F)s4)c3c2)CC1	InChI=1S/C27H30F2N8O4S2/c1-27(7-8-27)34-43(40,41)17-2-3-18-19(12-17)37(25-33-32-24(42-25)22(28)29)23-20(18)21(30-14-31-23)15-4-9-35(10-5-15)26(39)36-11-6-16(38)13-36/h2-3,12,14-16,22,34,38H,4-11,13H2,1H3	DJWWULBFFOLLNM-UHFFFAOYSA-N	87268	US20250388589, Example 132	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=87268	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=87268&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			170311358	252659702							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124584	CC1(NS(=O)(=O)c2ccc3c4c(C5CCN(C(=O)N6CCOCC6)CC5)ncnc4n(-c4nnc(C(F)F)s4)c3c2)CC1	InChI=1S/C27H30F2N8O4S2/c1-27(6-7-27)34-43(39,40)17-2-3-18-19(14-17)37(25-33-32-24(42-25)22(28)29)23-20(18)21(30-15-31-23)16-4-8-35(9-5-16)26(38)36-10-12-41-13-11-36/h2-3,14-16,22,34H,4-13H2,1H3	NFWKYCFKUPOHRQ-UHFFFAOYSA-N	87269	US20250388589, Example 133	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=87269	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=87269&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460882	252659703							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124585	CO[C@H]1CCN(C(=O)N2CCC(c3ncnc4c3c3ccc(S(=O)(=O)NC5(C#N)CC5)cc3n4-c3nnc(C(F)F)s3)CC2)C1	InChI=1S/C28H29F2N9O4S2/c1-43-17-6-11-38(13-17)27(40)37-9-4-16(5-10-37)22-21-19-3-2-18(45(41,42)36-28(14-31)7-8-28)12-20(19)39(24(21)33-15-32-22)26-35-34-25(44-26)23(29)30/h2-3,12,15-17,23,36H,4-11,13H2,1H3	FNYPSSDWMRECMO-UHFFFAOYSA-N	87270	US20250388589, Example 134	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=87270	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=87270&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			170311330	252659704							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124586	CO[C@@H]1CCN(C(=O)N2CCC(c3ncnc4c3c3ccc(S(=O)(=O)NC5(C#N)CC5)cc3n4-c3nnc(C(F)F)s3)CC2)C1	InChI=1S/C28H29F2N9O4S2/c1-43-17-6-11-38(13-17)27(40)37-9-4-16(5-10-37)22-21-19-3-2-18(45(41,42)36-28(14-31)7-8-28)12-20(19)39(24(21)33-15-32-22)26-35-34-25(44-26)23(29)30/h2-3,12,15-17,23,36H,4-11,13H2,1H3	FNYPSSDWMRECMO-UHFFFAOYSA-N	87271	(R)-N-(1-Cyanocyclo- propyl)-9-(5- (difluoromethyl)-1,3,4- thiadiazol-2-yl)-4-(1- (3-methoxypyrrolidine- 1-carbonyl)piperidin- 4-yl)-9H-pyrimido [4,5-b]indole-7- sulfonamide::US20250388589, Example 135	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=87271	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=87271&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460924	252659705							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124587	CN(C)[C@H]1CCN(C(=O)N2CCC(c3ncnc4c3c3ccc(S(=O)(=O)NC5(C#N)CC5)cc3n4-c3nnc(C(F)F)s3)CC2)C1	InChI=1S/C29H32F2N10O3S2/c1-38(2)18-7-12-40(14-18)28(42)39-10-5-17(6-11-39)23-22-20-4-3-19(46(43,44)37-29(15-32)8-9-29)13-21(20)41(25(22)34-16-33-23)27-36-35-26(45-27)24(30)31/h3-4,13,16-18,24,37H,5-12,14H2,1-2H3	CYNRSVUFRYMFKN-UHFFFAOYSA-N	87272	(S)-N-(1-Cyanocyclo- propyl)-9-(5- (difluoromethyl)-1,3,4- thiadiazol-2-yl)-4-(1- (3-(dimethylamino) pyrrolidine-1- carbonyl)piperidin-4- yl)-9H-pyrimido [4,5-b]indole-7- sulfonamide::US20250388589, Example 136	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=87272	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=87272&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460784	252659706							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124588	CN(C)[C@@H]1CCN(C(=O)N2CCC(c3ncnc4c3c3ccc(S(=O)(=O)NC5(C#N)CC5)cc3n4-c3nnc(C(F)F)s3)CC2)C1	InChI=1S/C29H32F2N10O3S2/c1-38(2)18-7-12-40(14-18)28(42)39-10-5-17(6-11-39)23-22-20-4-3-19(46(43,44)37-29(15-32)8-9-29)13-21(20)41(25(22)34-16-33-23)27-36-35-26(45-27)24(30)31/h3-4,13,16-18,24,37H,5-12,14H2,1-2H3	CYNRSVUFRYMFKN-UHFFFAOYSA-N	87273	(R)-N-(1-Cyanocyclo- propyl)-9-(5- (difluoromethyl)- 1,3,4-thiadiazol-2- yl)-4-(1-(3- (dimethylamino) pyrrolidine-1- carbonyl)piperidin- 4-yl)-9H- pyrimido[4,5-b] indole-7- sulfonamide::US20250388589, Example 137	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=87273	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=87273&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460897	252659707							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124589	N#CC1(NS(=O)(=O)c2ccc3c4c(C5CCN(C(=O)N6CC(O)C6)CC5)ncnc4n(-c4nnc(C(F)F)s4)c3c2)CC1	InChI=1S/C26H25F2N9O4S2/c27-21(28)23-32-33-24(42-23)37-18-9-16(43(40,41)34-26(12-29)5-6-26)1-2-17(18)19-20(30-13-31-22(19)37)14-3-7-35(8-4-14)25(39)36-10-15(38)11-36/h1-2,9,13-15,21,34,38H,3-8,10-11H2	HRWSFIFHXNCMAH-UHFFFAOYSA-N	87274	N-(1-cyanocyclo- propyl)-9-(5- (difluoromethyl)-1,3,4- thiadiazol-2-yl)-4- (1-(3-hydroxy- azetidine-1- carbonyl)piperidin-4- yl)-9H-pyrimido [4,5-b]indole-7- sulfonamide::US20250388589, Example 138	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=87274	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=87274&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460741	252659708							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124590	N#CC1(NS(=O)(=O)c2ccc3c4c(C5CCN(C(=O)N6CCCO6)CC5)ncnc4n(-c4nnc(C(F)F)s4)c3c2)CC1	InChI=1S/C26H25F2N9O4S2/c27-21(28)23-32-33-24(42-23)37-18-12-16(43(39,40)34-26(13-29)6-7-26)2-3-17(18)19-20(30-14-31-22(19)37)15-4-9-35(10-5-15)25(38)36-8-1-11-41-36/h2-3,12,14-15,21,34H,1,4-11H2	DJWGGGOMDDZAHZ-UHFFFAOYSA-N	87275	N-(1-cyanocyclo- propyl)-9-(5- (difluoromethyl)- 1,3,4-thiadiazol-2-yl)- 4-(1-isoxazolidine- 2-carbonyl)piperidin- 4-yl)-9H-pyrimido [4,5-b]indole-7- sulfonamide::US20250388589, Example 139	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=87275	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=87275&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460758	252659709							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124591	N#CC1(NS(=O)(=O)c2ccc3c4c(C5CCN(C(=O)N6CCOCC6)CC5)ncnc4n(-c4nnc(C(F)F)s4)c3c2)CC1	InChI=1S/C27H27F2N9O4S2/c28-22(29)24-33-34-25(43-24)38-19-13-17(44(40,41)35-27(14-30)5-6-27)1-2-18(19)20-21(31-15-32-23(20)38)16-3-7-36(8-4-16)26(39)37-9-11-42-12-10-37/h1-2,13,15-16,22,35H,3-12H2	HIZINHDDBQTNQZ-UHFFFAOYSA-N	87277	N-(1-cyanocyclo- propyl)-9-(5- (difluoromethyl)-1,3,4- thiadiazol-2-yl)-4-(1- (morpholine-4- carbonyl)piperidin-4- yl)-9H-pyrimido [4,5-b]indole-7- sulfonamide::US20250388589, Example 140	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=87277	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=87277&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460715	252659711							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124592	CN1CCN(C(=O)N2CCC(c3ncnc4c3c3ccc(S(=O)(=O)NC5(C#N)CC5)cc3n4-c3nnc(C(F)F)s3)CC2)CC1	InChI=1S/C28H30F2N10O3S2/c1-37-10-12-39(13-11-37)27(41)38-8-4-17(5-9-38)22-21-19-3-2-18(45(42,43)36-28(15-31)6-7-28)14-20(19)40(24(21)33-16-32-22)26-35-34-25(44-26)23(29)30/h2-3,14,16-17,23,36H,4-13H2,1H3	HHNKFNHZFIQXGY-UHFFFAOYSA-N	87278	N-(1-cyanocyclo- propyl)-9-(5- (difluoromethyl)-1,3,4- thiadiazol-2-yl)-4-(1- (4-methylpiperazine- 1-carbonyl)piperidin- 4-yl)-9H-pyrimido [4,5-b]indole-7- sulfonamide::US20250388589, Example 141	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=87278	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=87278&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460840	252659712							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124593	CC(O)CN(C)C(=O)N1CCC(c2ncnc3c2c2ccc(S(=O)(=O)NC4(C#N)CC4)cc2n3-c2nnc(C(F)F)s2)CC1	InChI=1S/C27H29F2N9O4S2/c1-15(39)12-36(2)26(40)37-9-5-16(6-10-37)21-20-18-4-3-17(44(41,42)35-27(13-30)7-8-27)11-19(18)38(23(20)32-14-31-21)25-34-33-24(43-25)22(28)29/h3-4,11,14-16,22,35,39H,5-10,12H2,1-2H3	PXCBHCFYFWSMOL-UHFFFAOYSA-N	87279	4-(7-(N-(1-cyanocyclo- propyl)sulfamoyl)-9-(5- (difluoromethyl)-1,3,4- thiadiazol-2-yl)-9H- pyrimido[4,5-b]indol- 4-yl)-N-(2- hydroxypropyl)-N- methylpiperidine-1- carboxamide::US20250388589, Example 142	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=87279	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=87279&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460933	252659713							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124594	CN(CCO)C(=O)N1CCC(c2ncnc3c2c2ccc(S(=O)(=O)NC4(C#N)CC4)cc2n3-c2nnc(C(F)F)s2)CC1	InChI=1S/C26H27F2N9O4S2/c1-35(10-11-38)25(39)36-8-4-15(5-9-36)20-19-17-3-2-16(43(40,41)34-26(13-29)6-7-26)12-18(17)37(22(19)31-14-30-20)24-33-32-23(42-24)21(27)28/h2-3,12,14-15,21,34,38H,4-11H2,1H3	FZVDMASEFIFICX-UHFFFAOYSA-N	87280	4-(7-(N-(1-cyanocyclo- propyl)sulfamoyl)-9-(5- (difluoromethyl)-1,3,4- thiadiazol-2-yl)-9H- pyrimido[4,5-b]indol- 4-yl)-N-(2- hydroxyethyl)-N- methylpiperidine-1- carboxamide::US20250388589, Example 143	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=87280	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=87280&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460929	252659714							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124595	COCCN(C)C(=O)N1CCC(c2ncnc3c2c2ccc(S(=O)(=O)NC4(C#N)CC4)cc2n3-c2nnc(C(F)F)s2)CC1	InChI=1S/C27H29F2N9O4S2/c1-36(11-12-42-2)26(39)37-9-5-16(6-10-37)21-20-18-4-3-17(44(40,41)35-27(14-30)7-8-27)13-19(18)38(23(20)32-15-31-21)25-34-33-24(43-25)22(28)29/h3-4,13,15-16,22,35H,5-12H2,1-2H3	XTDPSEFPQDWMBN-UHFFFAOYSA-N	87281	4-(7-(N-(1-cyanocyclo- propyl)sulfamoyl)-9-(5- (difluoromethyl)-1,3,4- thiadiazol-2-yl)-9H- pyrimido[4,5-b]indol- 4-yl)-N-(2- methoxyethyl)-N- methylpiperidine-1- carboxamide::US20250388589, Example 144	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=87281	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=87281&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460732	252659715							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124596	CON(C)C(=O)N1CCC(c2ncnc3c2c2ccc(S(=O)(=O)NC4(C#N)CC4)cc2n3-c2nnc(C(F)F)s2)CC1	InChI=1S/C25H25F2N9O4S2/c1-34(40-2)24(37)35-9-5-14(6-10-35)19-18-16-4-3-15(42(38,39)33-25(12-28)7-8-25)11-17(16)36(21(18)30-13-29-19)23-32-31-22(41-23)20(26)27/h3-4,11,13-14,20,33H,5-10H2,1-2H3	ULTHDICJNGGKFF-UHFFFAOYSA-N	87282	US20250388589, Example 145	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=87282	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=87282&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460998	252659716							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124597	CN1CCC(c2ncnc3c2c2ccc(S(=O)(=O)NC4(C#N)CC4)cc2n3-c2nnc(C(F)F)s2)CC1	InChI=1S/C23H22F2N8O2S2/c1-32-8-4-13(5-9-32)18-17-15-3-2-14(37(34,35)31-23(11-26)6-7-23)10-16(15)33(20(17)28-12-27-18)22-30-29-21(36-22)19(24)25/h2-3,10,12-13,19,31H,4-9H2,1H3	CCTBTEXFPSFUND-UHFFFAOYSA-N	87283	US20250388589, Example 146	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=87283	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=87283&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460911	252659717							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124598	N#CC1(N[S@TB20](=O)(=O)c2ccc3c4c(C5CCN(CC(F)(F)F)CC5)ncnc4n(-c4nnc(C(F)F)s4)c3c2)CC1	InChI=1S/C24H21F5N8O2S2/c25-19(26)21-33-34-22(40-21)37-16-9-14(41(38,39)35-23(10-30)5-6-23)1-2-15(16)17-18(31-12-32-20(17)37)13-3-7-36(8-4-13)11-24(27,28)29/h1-2,9,12-13,19,35H,3-8,11H2	VZJVWVWNXPABAR-UHFFFAOYSA-N	87284	US20250388589, Example 147	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=87284	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=87284&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			178289675	252659718							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124599	CC(C)C(=O)N1CCC(c2ncnc3c2c2cc(F)c(S(=O)(=O)NC4(C)CC4)cc2n3-c2nnc(C(F)F)s2)CC1	InChI=1S/C26H28F3N7O3S2/c1-13(2)24(37)35-8-4-14(5-9-35)20-19-15-10-16(27)18(41(38,39)34-26(3)6-7-26)11-17(15)36(22(19)31-12-30-20)25-33-32-23(40-25)21(28)29/h10-14,21,34H,4-9H2,1-3H3	ZTRAXHUSUPCOHA-UHFFFAOYSA-N	87285	US20250388589, Example 148	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=87285	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=87285&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460781	252659719							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124600	CC(C)C(=O)N1CCC(c2ncnc3c2c2cc(F)c(S(=O)(=O)NC4(C)CC4)cc2n3-c2nnc(C(F)F)s2)C[C@@H]1C	InChI=1S/C27H30F3N7O3S2/c1-13(2)25(38)36-8-5-15(9-14(36)3)21-20-16-10-17(28)19(42(39,40)35-27(4)6-7-27)11-18(16)37(23(20)32-12-31-21)26-34-33-24(41-26)22(29)30/h10-15,22,35H,5-9H2,1-4H3	XOJWNWGXWZCQND-UHFFFAOYSA-N	87286	US20250388589, Example 149	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=87286	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=87286&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171461035	252659720							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124601	C[C@H]1CC(c2ncnc3c2c2ccc(S(=O)(=O)NC4(C#N)CC4)cc2n3-c2nnc(C(F)F)s2)CCN1	InChI=1S/C23H22F2N8O2S2/c1-12-8-13(4-7-27-12)18-17-15-3-2-14(37(34,35)32-23(10-26)5-6-23)9-16(15)33(20(17)29-11-28-18)22-31-30-21(36-22)19(24)25/h2-3,9,11-13,19,27,32H,4-8H2,1H3	FNRBGCJWMPWPRD-UHFFFAOYSA-N	87287	US20250388589, Example 150	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=87287	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=87287&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460813	252659721							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124602	CC(C)C(=O)N1CCC(c2ncnc3c2c2ccc(S(=O)(=O)NC4(C)CC4)cc2n3-c2nnc(C(F)F)s2)C[C@@H]1C	InChI=1S/C27H31F2N7O3S2/c1-14(2)25(37)35-10-7-16(11-15(35)3)21-20-18-6-5-17(41(38,39)34-27(4)8-9-27)12-19(18)36(23(20)31-13-30-21)26-33-32-24(40-26)22(28)29/h5-6,12-16,22,34H,7-11H2,1-4H3	PUORKFLDTHCMEO-UHFFFAOYSA-N	87288	US20250388589, Example 151	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=87288	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=87288&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			178289676	252659722							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124603	CC(C)C(=O)N1CC=C(c2ncnc3c2c2ccc(S(=O)(=O)NC4(C)CC4)cc2n3-c2nnc(C(F)F)s2)CC1	InChI=1S/C26H27F2N7O3S2/c1-14(2)24(36)34-10-6-15(7-11-34)20-19-17-5-4-16(40(37,38)33-26(3)8-9-26)12-18(17)35(22(19)30-13-29-20)25-32-31-23(39-25)21(27)28/h4-6,12-14,21,33H,7-11H2,1-3H3	UORQTBGTBNEBFJ-UHFFFAOYSA-N	87289	US20250388589, Example 152	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=87289	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=87289&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			178289677	252659723							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124604	CN(C)C(=O)N1CCC(c2ncnc3c2c2ccc(S(=O)(=O)NC4(C)CC4)cc2n3-c2nnc(C(F)F)s2)CC1	InChI=1S/C25H28F2N8O3S2/c1-25(8-9-25)32-40(37,38)15-4-5-16-17(12-15)35(23-31-30-22(39-23)20(26)27)21-18(16)19(28-13-29-21)14-6-10-34(11-7-14)24(36)33(2)3/h4-5,12-14,20,32H,6-11H2,1-3H3	SSKOFMPRSOIPLT-UHFFFAOYSA-N	87290	US20250388589, Example 153	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=87290	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=87290&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460722	252659724							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124605	CC(C)C(=O)N1CCN(c2ncnc3c2c2ccc(S(=O)(=O)NC4(C#N)CC4)cc2n3-c2nnc(C(F)F)s2)C[C@@H]1CO	InChI=1S/C26H27F2N9O4S2/c1-14(2)24(39)36-8-7-35(10-15(36)11-38)21-19-17-4-3-16(43(40,41)34-26(12-29)5-6-26)9-18(17)37(22(19)31-13-30-21)25-33-32-23(42-25)20(27)28/h3-4,9,13-15,20,34,38H,5-8,10-11H2,1-2H3	VSYWXFWQIAKREH-UHFFFAOYSA-N	87291	US20250388589, Example 154	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=87291	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=87291&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			170311303	252659725							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124606	CCN1CCN(c2ncnc3c2c2ccc(S(=O)(=O)NC4(C#N)CC4)cc2n3-c2nnc(C(F)F)s2)CC1=O	InChI=1S/C23H21F2N9O3S2/c1-2-32-7-8-33(10-16(32)35)19-17-14-4-3-13(39(36,37)31-23(11-26)5-6-23)9-15(14)34(20(17)28-12-27-19)22-30-29-21(38-22)18(24)25/h3-4,9,12,18,31H,2,5-8,10H2,1H3	JSBDJKLXUULEPJ-UHFFFAOYSA-N	87292	N-(1-cyanocyclopropyl)- 9-(5-(difluoromethyl)- 1,3,4-thiadiazol-2- yl)-4-(4-ethyl-3- oxopiperazin-1-yl)-9H- pyrimido[4,5-b]indole-7- sulfonamide::US20250388589, Example 155	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=87292	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=87292&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460787	252659726							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124607	N#CC1(N[S@SP1](=O)(=O)c2ccc3c4c(N5CCn6c(nnc6C(F)(F)F)C5)ncnc4n(-c4nnc(C(F)F)s4)c3c2)CC1	InChI=1S/C23H16F5N11O2S2/c24-16(25)19-33-35-21(42-19)39-13-7-11(43(40,41)36-22(9-29)3-4-22)1-2-12(13)15-17(30-10-31-18(15)39)37-5-6-38-14(8-37)32-34-20(38)23(26,27)28/h1-2,7,10,16,36H,3-6,8H2	QECJPVIFPJUFCF-UHFFFAOYSA-N	87293	N-(1- cyanocyclopropyl)-9-(5- (difluoromethyl)-1,3,4- thiadiazol-2-yl)-4-(3- (trifluoromethyl)-5,6- dihydro-[1,2,4]triazolo [4,3-a]pyrazin- 7(8H)-yl)-9H-pyrimido [4,5-b]indole-7-  sulfonamide::US20250388589, Example 156	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=87293	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=87293&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460919	252659727							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124608	CCCN1CCN(c2ncnc3c2c2ccc(S(=O)(=O)NC4(C#N)CC4)cc2n3-c2nnc(C(F)F)s2)C[C@@H]1C	InChI=1S/C25H27F2N9O2S2/c1-3-8-34-9-10-35(12-15(34)2)21-19-17-5-4-16(40(37,38)33-25(13-28)6-7-25)11-18(17)36(22(19)30-14-29-21)24-32-31-23(39-24)20(26)27/h4-5,11,14-15,20,33H,3,6-10,12H2,1-2H3	WQHHRXMPMQMBPL-UHFFFAOYSA-N	87294	(S)-N-(1- cyanocyclopropyl)-9-(5- (difluoromethyl)-1,3,4- thiadiazol-2-yl)-4-(3- methyl-4- propylpiperazin- 1-yl)-9H-pyrimido [4,5-b]indole-7- sulfonamide::US20250388589, Example 157	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=87294	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=87294&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460829	252659728							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124609	CC(C)CN1CCN(c2ncnc3c2c2ccc(S(=O)(=O)NC4(C#N)CC4)cc2n3-c2nnc(C(F)F)s2)CC1=O	InChI=1S/C25H25F2N9O3S2/c1-14(2)10-34-7-8-35(11-18(34)37)21-19-16-4-3-15(41(38,39)33-25(12-28)5-6-25)9-17(16)36(22(19)30-13-29-21)24-32-31-23(40-24)20(26)27/h3-4,9,13-14,20,33H,5-8,10-11H2,1-2H3	YAHBGGPBFWHMMO-UHFFFAOYSA-N	87295	N-(1- cyanocyclopropyl)-9-(5- (difluoromethyl)-1,3,4- thiadiazol-2-yl)-4-(4- isobutyl-3- oxopiperazin- 1-yl)-9H-pyrimido [4,5-b]indole-7- sulfonamide::US20250388589, Example 158	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=87295	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=87295&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460767	252659729							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124610	CC1CN(c2ncnc3c2c2ccc([S@SP2](=O)(=O)NC4(C#N)CC4)cc2n3-c2nnc(C(F)F)s2)CCN1CC(F)(F)F	InChI=1S/C24H22F5N9O2S2/c1-13-9-36(6-7-37(13)11-24(27,28)29)19-17-15-3-2-14(42(39,40)35-23(10-30)4-5-23)8-16(15)38(20(17)32-12-31-19)22-34-33-21(41-22)18(25)26/h2-3,8,12-13,18,35H,4-7,9,11H2,1H3	IGUQMFCAWQVQPE-UHFFFAOYSA-N	87296	(S)-N-(1- cyanocyclopropyl)-9-(5- (difluoromethyl)-1,3,4- thiadiazol-2-yl)-4- (3-methyl-4- (2,2,2-trifluoroethyl) piperazin-1-yl)- 9H-pyrimido[4,5-b] indole-7- sulfonamide::US20250388589, Example 159	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=87296	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=87296&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460954	252659730							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124611	N#CC1(NS(=O)(=O)c2ccc3c4c(N5CCN6CCC[C@H]6C5)ncnc4n(-c4nnc(C(F)F)s4)c3c2)CC1	InChI=1S/C24H23F2N9O2S2/c25-19(26)22-30-31-23(38-22)35-17-10-15(39(36,37)32-24(12-27)5-6-24)3-4-16(17)18-20(28-13-29-21(18)35)34-9-8-33-7-1-2-14(33)11-34/h3-4,10,13-14,19,32H,1-2,5-9,11H2	UJPPVMVNNXCQKH-UHFFFAOYSA-N	87297	US20250388589, Example 160	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=87297	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=87297&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			170311361	252659731							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124612	N#CC1(NS(=O)(=O)c2ccc3c4c(N5CCN6CCOC[C@H]6C5)ncnc4n(-c4nnc(C(F)F)s4)c3c2)CC1	InChI=1S/C24H23F2N9O3S2/c25-19(26)22-30-31-23(39-22)35-17-9-15(40(36,37)32-24(12-27)3-4-24)1-2-16(17)18-20(28-13-29-21(18)35)34-6-5-33-7-8-38-11-14(33)10-34/h1-2,9,13-14,19,32H,3-8,10-11H2	RURGLZXQQPBOMJ-UHFFFAOYSA-N	87298	(R)-N-(1- cyanocyclopropyl)-9-(5- (difluoromethyl)-1,3,4- thiadiazol-2-yl)-4- (hexahydropyrazino [2,1-c][1,4]oxazin- 8(1H)-yl)-9H- pyrimido[4,5-b] indole-7-sulfonamide::US20250388589, Example 161	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=87298	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=87298&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460807	252659732							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124613	N#CC1(NS(=O)(=O)c2ccc3c4c(N5CCN6CCOC[C@@H]6C5)ncnc4n(-c4nnc(C(F)F)s4)c3c2)CC1	InChI=1S/C24H23F2N9O3S2/c25-19(26)22-30-31-23(39-22)35-17-9-15(40(36,37)32-24(12-27)3-4-24)1-2-16(17)18-20(28-13-29-21(18)35)34-6-5-33-7-8-38-11-14(33)10-34/h1-2,9,13-14,19,32H,3-8,10-11H2	RURGLZXQQPBOMJ-UHFFFAOYSA-N	87299	(S)-N-(1- cyanocyclopropyl)-9-(5- (difluoromethyl)-1,3,4- thiadiazol-2-yl)-4- (hexahydropyrazino [2,1-c][1,4]oxazin- 8(1H)-yl)-9H- pyrimido[4,5-b]indole- 7-sulfonamide::US20250388589, Example 162	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=87299	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=87299&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460917	252659733							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124614	CCN1CCN(c2ncnc3c2c2ccc(S(=O)(=O)NC4(C#N)CC4)cc2n3-c2nnc(C(F)F)s2)C[C@@H]1C	InChI=1S/C24H25F2N9O2S2/c1-3-33-8-9-34(11-14(33)2)20-18-16-5-4-15(39(36,37)32-24(12-27)6-7-24)10-17(16)35(21(18)29-13-28-20)23-31-30-22(38-23)19(25)26/h4-5,10,13-14,19,32H,3,6-9,11H2,1-2H3	XSZCAIYDIABUAR-UHFFFAOYSA-N	87300	(S)-N-(1- cyanocyclopropyl)-9-(5- (difluoromethyl)-1,3,4- thiadiazol-2-yl)-4-(4- ethyl-3-methylpiperazin- 1-yl)-9H-pyrimido [4,5-b]indole-7- sulfonamide::US20250388589, Example 163	Poly(ADP-ribose) glycohydrolase	Homo sapiens		 550							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=87300	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=87300&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460979	252659734							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124615	C[C@H]1CN(c2ncnc3c2c2ccc(S(=O)(=O)NC4(C#N)CC4)cc2n3-c2nnc(C(F)F)s2)CCN1CC1CC1	InChI=1S/C26H27F2N9O2S2/c1-15-11-36(9-8-35(15)12-16-2-3-16)22-20-18-5-4-17(41(38,39)34-26(13-29)6-7-26)10-19(18)37(23(20)31-14-30-22)25-33-32-24(40-25)21(27)28/h4-5,10,14-16,21,34H,2-3,6-9,11-12H2,1H3	QTNDGXPTENHCPR-UHFFFAOYSA-N	87301	(S)-N-(1- cyanocyclopropyl)-4-(4- (cyclopropylmethyl)-3- methylpiperazin-1-yl)- 9-(5-(difluoromethyl)- 1,3,4-thiadiazol-2-yl)- 9H-pyrimido[4,5-b] indole-7-sulfonamide::US20250388589, Example 164	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=87301	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=87301&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460738	252659735							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124616	N#CC1(NS(=O)(=O)c2ccc3c4c(N5CC6OCCOC6C5)ncnc4n(-c4nnc(C(F)F)s4)c3c2)CC1	InChI=1S/C23H20F2N8O4S2/c24-18(25)21-29-30-22(38-21)33-14-7-12(39(34,35)31-23(10-26)3-4-23)1-2-13(14)17-19(27-11-28-20(17)33)32-8-15-16(9-32)37-6-5-36-15/h1-2,7,11,15-16,18,31H,3-6,8-9H2	UDPTUCTZEIFMQA-UHFFFAOYSA-N	87302	N-(1- Cyanocyclopropyl)-9-(5- (difluoromethyl)-1,3,4- thiadiazol-2-yl)-4- (hexahydro-6H-[1,4] dioxino[2,3-c]pyrrol-6- yl)-9H-pyrimido[4,5-b] indole-7-sulfonamide::US20250388589, Example 165	Poly(ADP-ribose) glycohydrolase	Homo sapiens		 550							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=87302	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=87302&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460866	252659736							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124617	N#CC1(NS(=O)(=O)c2ccc3c4c(N5CCS(=O)(=O)CC5)ncnc4n(-c4nnc(C(F)F)s4)c3c2)CC1	InChI=1S/C21H18F2N8O4S3/c22-16(23)19-27-28-20(36-19)31-14-9-12(38(34,35)29-21(10-24)3-4-21)1-2-13(14)15-17(25-11-26-18(15)31)30-5-7-37(32,33)8-6-30/h1-2,9,11,16,29H,3-8H2	DUWUXEYRZGZCHL-UHFFFAOYSA-N	87303	N-(1- cyanocyclopropyl)-9-(5- (difluoromethyl)-1,3,4- thiadiazol-2-yl)-4-(1,1- dioxidothiomorpholino)- 9H-pyrimido[4,5-b] indole-7-sulfonamide::US20250388589, Example 166	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=87303	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=87303&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			174230432	252659737							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124618	N#CC1(NS(=O)(=O)c2ccc3c4c(N5CCN6C(=O)OC[C@H]6C5)ncnc4n(-c4nnc(C(F)F)s4)c3c2)CC1	InChI=1S/C23H19F2N9O4S2/c24-17(25)20-29-30-21(39-20)34-15-7-13(40(36,37)31-23(10-26)3-4-23)1-2-14(15)16-18(27-11-28-19(16)34)32-5-6-33-12(8-32)9-38-22(33)35/h1-2,7,11-12,17,31H,3-6,8-9H2	YLVNXWRXVTXVOJ-UHFFFAOYSA-N	87304	(R)-N-(1- cyanocyclopropyl)-9-(5- (difluoromethyl)-1,3,4- thiadiazol-2-yl)-4-(3- oxotetrahydro-3H- oxazolo[3,4-a]pyrazin- 7(1H)-yl)-9H-pyrimido [4,5-b]indole-7- sulfonamide::US20250388589, Example 167	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=87304	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=87304&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171461055	252659738							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124619	N#CC1(NS(=O)(=O)c2ccc3c4c(N5CCN6C(=O)COC[C@H]6C5)ncnc4n(-c4nnc(C(F)F)s4)c3c2)CC1	InChI=1S/C24H21F2N9O4S2/c25-19(26)22-30-31-23(40-22)35-16-7-14(41(37,38)32-24(11-27)3-4-24)1-2-15(16)18-20(28-12-29-21(18)35)33-5-6-34-13(8-33)9-39-10-17(34)36/h1-2,7,12-13,19,32H,3-6,8-10H2	RDDGZIJUJSRLIU-UHFFFAOYSA-N	87305	US20250388589, Example 168	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=87305	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=87305&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			170311373	252659739							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124620	N#CC1(NS(=O)(=O)c2ccc3c4c(N5C[C@H]6COC[C@H]6C5)ncnc4n(-c4nnc(C(F)F)s4)c3c2)CC1	InChI=1S/C23H20F2N8O3S2/c24-18(25)21-29-30-22(37-21)33-16-5-14(38(34,35)31-23(10-26)3-4-23)1-2-15(16)17-19(27-11-28-20(17)33)32-6-12-8-36-9-13(12)7-32/h1-2,5,11-13,18,31H,3-4,6-9H2	AYQCYPSJQMHLGB-UHFFFAOYSA-N	87306	N-(1-Cyanocyclo- propyl)-9-(5- (difluoromethyl)-1,3,4- thiadiazol-2-yl)-4- ((3aR,6aS)-tetrahydro- 1H-furo[3,4-c]pyrrol- 5(3H)-yl)-9H-pyrimido [4,5-b]indole-7- sulfonamide::US20250388589, Example 169	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=87306	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=87306&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460861	252659740							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124621	N#CC1(NS(=O)(=O)c2ccc3c4c(N5CCCOCC5)ncnc4n(-c4nnc(C(F)F)s4)c3c2)CC1	InChI=1S/C22H20F2N8O3S2/c23-17(24)20-28-29-21(36-20)32-15-10-13(37(33,34)30-22(11-25)4-5-22)2-3-14(15)16-18(26-12-27-19(16)32)31-6-1-8-35-9-7-31/h2-3,10,12,17,30H,1,4-9H2	OMYVQTAETQSHEZ-UHFFFAOYSA-N	87307	N-(1-Cyanocyclo- propyl)-9-(5- (difluoromethyl)-1,3,4- thiadiazol-2-yl)-4-(1,4- oxazepan-4-yl)-9H- pyrimido[4,5-b]indole-7- sulfonamide::US20250388589, Example 170	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=87307	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=87307&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460996	252659741							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124622	CO[C@@H]1CCN(c2ncnc3c2c2ccc(S(=O)(=O)NC4(C#N)CC4)cc2n3-c2nnc(C(F)F)s2)C[C@@H]1F	InChI=1S/C23H21F3N8O3S2/c1-37-16-4-7-33(9-14(16)24)19-17-13-3-2-12(39(35,36)32-23(10-27)5-6-23)8-15(13)34(20(17)29-11-28-19)22-31-30-21(38-22)18(25)26/h2-3,8,11,14,16,18,32H,4-7,9H2,1H3	JAFGAXJAQQESNY-UHFFFAOYSA-N	87308	N-(1-Cyanocyclo- propyl)-9-(5- (difluoromethyl)-1,3,4- thiadiazol-2-yl)-4- ((3S,4R)-3-fluoro-4- methoxypiperidin-1-yl)- 9H-pyrimido[4,5-b] indole-7-sulfonamide::US20250388589, Example 171	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=87308	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=87308&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171461042	252659742							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124623	CO[C@H]1CCN(c2ncnc3c2c2ccc(S(=O)(=O)NC4(C#N)CC4)cc2n3-c2nnc(C(F)F)s2)C[C@@H]1F	InChI=1S/C23H21F3N8O3S2/c1-37-16-4-7-33(9-14(16)24)19-17-13-3-2-12(39(35,36)32-23(10-27)5-6-23)8-15(13)34(20(17)29-11-28-19)22-31-30-21(38-22)18(25)26/h2-3,8,11,14,16,18,32H,4-7,9H2,1H3	JAFGAXJAQQESNY-UHFFFAOYSA-N	87309	N-(1-cyanocyclo- propyl)-9-(5- (difluoromethyl)-1,3,4- thiadiazol-2-yl)-4- ((3S,4S)-3-fluoro-4- methoxypiperidin-1-yl)- 9H-pyrimido[4,5-b] indole-7-sulfonamide::US20250388589, Example 172	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=87309	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=87309&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460688	252659743							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124624	CO[C@H]1CCN(c2ncnc3c2c2ccc(S(=O)(=O)NC4(C#N)CC4)cc2n3-c2nnc(C(F)F)s2)C[C@H]1F	InChI=1S/C23H21F3N8O3S2/c1-37-16-4-7-33(9-14(16)24)19-17-13-3-2-12(39(35,36)32-23(10-27)5-6-23)8-15(13)34(20(17)29-11-28-19)22-31-30-21(38-22)18(25)26/h2-3,8,11,14,16,18,32H,4-7,9H2,1H3	JAFGAXJAQQESNY-UHFFFAOYSA-N	87310	N-(1-cyanocyclo- propyl)-9-(5- (difluoromethyl)-1,3,4- thiadiazol-2-yl)-4- ((3R,4S)-3-fluoro-4- methoxypiperidin-1-yl)- 9H-pyrimido[4,5-b] indole-7-sulfonamide::US20250388589, Example 173	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=87310	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=87310&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460819	252659744							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124625	N#CC1(NS(=O)(=O)c2ccc3c4c(N5CC[C@@H](O)[C@@H](F)C5)ncnc4n(-c4nnc(C(F)F)s4)c3c2)CC1	InChI=1S/C22H19F3N8O3S2/c23-13-8-32(6-3-15(13)34)18-16-12-2-1-11(38(35,36)31-22(9-26)4-5-22)7-14(12)33(19(16)28-10-27-18)21-30-29-20(37-21)17(24)25/h1-2,7,10,13,15,17,31,34H,3-6,8H2	QKZDSEAYDVWSIE-UHFFFAOYSA-N	87311	N-(1-cyanocyclo- propyl)-9-(5- (difluoromethyl)-1,3,4- thiadiazol-2-yl)-4- ((3S,4R)-3-fluoro-4- hydroxypiperidin-1-yl)- 9H-pyrimido[4,5-b] indole-7-sulfonamide::US20250388589, Example 174	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=87311	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=87311&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460710	252659745							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124626	CN(C)C1CCN(c2ncnc3c2c2ccc(S(=O)(=O)NC4(C#N)CC4)cc2n3-c2nnc(C(F)F)s2)C[C@@H]1F	InChI=1S/C24H24F3N9O2S2/c1-34(2)16-5-8-35(10-15(16)25)20-18-14-4-3-13(40(37,38)33-24(11-28)6-7-24)9-17(14)36(21(18)30-12-29-20)23-32-31-22(39-23)19(26)27/h3-4,9,12,15-16,19,33H,5-8,10H2,1-2H3	SUHUIBVLLNJBDK-UHFFFAOYSA-N	87312	N-(1-cyanocyclo- propyl)-9-(5- (difluoromethyl)-1,3,4- thiadiazol-2-yl)-4- ((3S)-4-(dimethylamino)- 3-fluoropiperidin-1-yl)- 9H-pyrimido[4,5-b] indole-7-sulfonamide::US20250388589, Example 175	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=87312	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=87312&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460726	252659746							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124627	N#CC1(NS(=O)(=O)c2ccc3c4c(N5CC6CC(C5)O6)ncnc4n(-c4nnc(C(F)F)s4)c3c2)CC1	InChI=1S/C22H18F2N8O3S2/c23-17(24)20-28-29-21(36-20)32-15-6-13(37(33,34)30-22(9-25)3-4-22)1-2-14(15)16-18(26-10-27-19(16)32)31-7-11-5-12(8-31)35-11/h1-2,6,10-12,17,30H,3-5,7-8H2	XALVAYZXPSJGIA-UHFFFAOYSA-N	87313	4-(6-oxa-3-azabicyclo [3.1.1]heptan-3-yl)-N- (1-cyanocyclopropyl)-9- (5-(difluoromethyl)- 1,3,4-thiadiazol-2-yl)- 9H-pyrimido[4,5-b] indole-7-sulfonamide::US20250388589, Example 176	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=87313	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=87313&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460760	252659747							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124628	N#CC1(NS(=O)(=O)c2ccc3c4c(N5C[C@@H]6C[C@H]5CO6)ncnc4n(-c4nnc(C(F)F)s4)c3c2)CC1	InChI=1S/C22H18F2N8O3S2/c23-17(24)20-28-29-21(36-20)32-15-6-13(37(33,34)30-22(9-25)3-4-22)1-2-14(15)16-18(26-10-27-19(16)32)31-7-12-5-11(31)8-35-12/h1-2,6,10-12,17,30H,3-5,7-8H2	CCAYPOOOWTWYDY-UHFFFAOYSA-N	87314	4-((1S,4S)-2-oxa-5- azabicyclo[2.2.1]heptan- 5-yl)-N-(1-cyanocyclo- propyl)-9-(5- (difluoromethyl)-1,3,4- thiadiazol-2-yl)- 9H-pyrimido[4,5-b] indole-7-sulfonamide::US20250388589, Example 177	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=87314	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=87314&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460733	252659748							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124629	COCCN1CCN(c2ncnc3c2c2ccc(S(=O)(=O)NC4(C#N)CC4)cc2n3-c2nnc(C(F)F)s2)C[C@@H]1C	InChI=1S/C25H27F2N9O3S2/c1-15-12-35(8-7-34(15)9-10-39-2)21-19-17-4-3-16(41(37,38)33-25(13-28)5-6-25)11-18(17)36(22(19)30-14-29-21)24-32-31-23(40-24)20(26)27/h3-4,11,14-15,20,33H,5-10,12H2,1-2H3	LQKZOUQQTYNWIW-UHFFFAOYSA-N	87316	(S)-N-(1-cyanocyclo- propyl)-9-(5- (difluoromethyl)-1,3,4- thiadiazol-2-yl)-4-(4- (2-methoxyethyl)-3- methylpiperazin-1-yl)- 9H-pyrimido[4,5-b] indole-7-sulfonamide::US20250388589, Example 178	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=87316	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=87316&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460785	252659749							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124630	CN(C)C(=O)N1CCC(c2ncnc3c2c2ccc(S(=O)(=O)NC4(C)CC4)cc2n3-c2nnc(C(F)F)s2)CC1	InChI=1S/C25H28F2N8O3S2/c1-25(8-9-25)32-40(37,38)15-4-5-16-17(12-15)35(23-31-30-22(39-23)20(26)27)21-18(16)19(28-13-29-21)14-6-10-34(11-7-14)24(36)33(2)3/h4-5,12-14,20,32H,6-11H2,1-3H3	SSKOFMPRSOIPLT-UHFFFAOYSA-N	87317	1-(7-(N-(1-Cyanocyclo- propyl)sulfamoyl)-9- (5-(difluoromethyl)-1,3,4- thiadiazol-2-yl)- 9H-pyrimido[4,5-b] indol-4-yl)-N,N- dimethylpiperidine-4- carboxamide::US20250388589, Example 179	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=87317	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=87317&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460722	252659750							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124631	CN(C)C1CCN(c2ncnc3c2c2ccc(S(=O)(=O)NC4(C#N)CC4)cc2n3-c2nnc(C(F)F)s2)CC1=O	InChI=1S/C24H23F2N9O3S2/c1-33(2)15-5-8-34(10-17(15)36)20-18-14-4-3-13(40(37,38)32-24(11-27)6-7-24)9-16(14)35(21(18)29-12-28-20)23-31-30-22(39-23)19(25)26/h3-4,9,12,15,19,32H,5-8,10H2,1-2H3	FPCABAPWRVKZSM-UHFFFAOYSA-N	87318	N-(1-Cyanocyclo- propyl)-9-(5- (difluoromethyl)-1,3,4- thiadiazol-2-yl)-4-(4- isopropyl-3-oxopiperazin- 1-yl)- 9H-pyrimido[4,5-b] indole-7-sulfonamide::US20250388589, Example 180	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=87318	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=87318&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			178289678	252659751							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124632	N#CC1(NS(=O)(=O)c2ccc3c4c(N5CCc6cc(CO)cnc6C5)ncnc4n(-c4nnc(C(F)F)s4)c3c2)CC1	InChI=1S/C26H21F2N9O3S2/c27-21(28)24-33-34-25(41-24)37-19-8-16(42(39,40)35-26(12-29)4-5-26)1-2-17(19)20-22(31-13-32-23(20)37)36-6-3-15-7-14(11-38)9-30-18(15)10-36/h1-2,7-9,13,21,35,38H,3-6,10-11H2	ZQDLKRAWCIZKCC-UHFFFAOYSA-N	87320	N-(1-Cyanocyclo- propyl)-9-(5- (difluoromethyl)-1,3,4- thiadiazol-2-yl)-4-(3- (hydroxymethyl)-5,8- dihydro-1,7- napthyridin-7(6H)-yl)- 9H-pyrimido[4,5-b] indole-7-sulfonamide::US20250388589, Example 181	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=87320	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=87320&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460935	252659753							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124633	N#CC1(NS(=O)(=O)c2ccc3c4c(N5CCC6(CCCO6)CC5)ncnc4n(-c4nnc(C(F)F)s4)c3c2)CC1	InChI=1S/C25H24F2N8O3S2/c26-19(27)22-31-32-23(39-22)35-17-12-15(40(36,37)33-24(13-28)5-6-24)2-3-16(17)18-20(29-14-30-21(18)35)34-9-7-25(8-10-34)4-1-11-38-25/h2-3,12,14,19,33H,1,4-11H2	KXKXHKVMZXAHGO-UHFFFAOYSA-N	87321	N-(1-Cyanocyclo- propyl)-9-(5- (difluoromethyl)-1,3,4- thiadiazol-2-yl)-4-(1- oxa-8-azaspiro[4.5] decan-8-yl)- 9H-pyrimido[4,5-b] indole-7-sulfonamide::US20250388589, Example 182	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=87321	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=87321&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460702	252659754							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124634	N#CC1(NS(=O)(=O)c2ccc3c4c(N5CCC6(CCOC6)CC5)ncnc4n(-c4nnc(C(F)F)s4)c3c2)CC1	InChI=1S/C25H24F2N8O3S2/c26-19(27)22-31-32-23(39-22)35-17-11-15(40(36,37)33-25(12-28)3-4-25)1-2-16(17)18-20(29-14-30-21(18)35)34-8-5-24(6-9-34)7-10-38-13-24/h1-2,11,14,19,33H,3-10,13H2	LWBWOBKMKTVJDZ-UHFFFAOYSA-N	87322	N-(1-Cyanocyclo- propyl)-9-(5- (difluoromethyl)-1,3,4- thiadiazol-2-yl)-4-(2- oxa-8-azaspiro[4.5] decan-8-yl)- 9H-pyrimido[4,5-b] indole-7-sulfonamide::US20250388589, Example 183	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=87322	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=87322&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460698	252659755							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124635	CC1(NS(=O)(=O)c2ccc3c4c(N5CCN6CCOC[C@H]6C5)ncnc4n(-c4nnc(C(F)F)s4)c3c2)CC1	InChI=1S/C24H26F2N8O3S2/c1-24(4-5-24)31-39(35,36)15-2-3-16-17(10-15)34(23-30-29-22(38-23)19(25)26)21-18(16)20(27-13-28-21)33-7-6-32-8-9-37-12-14(32)11-33/h2-3,10,13-14,19,31H,4-9,11-12H2,1H3	UEOZMPMUBRTWQG-UHFFFAOYSA-N	87323	US20250388589, Example 184	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=87323	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=87323&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			170311332	242053804							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124636	Cc1nnc(-n2c3cc(S(=O)(=O)NC4(C#N)CC4)ccc3c3c(N4CCN(C(=O)C5CC5)CC4)ncnc32)s1	InChI=1S/C25H25N9O3S2/c1-15-29-30-24(38-15)34-19-12-17(39(36,37)31-25(13-26)6-7-25)4-5-18(19)20-21(27-14-28-22(20)34)32-8-10-33(11-9-32)23(35)16-2-3-16/h4-5,12,14,16,31H,2-3,6-11H2,1H3	FJGFNVREIPJJSQ-UHFFFAOYSA-N	87324	US20250388589, Example 185	Poly(ADP-ribose) glycohydrolase	Homo sapiens		 550							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=87324	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=87324&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460843	252659756							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124637	CC(C)c1nnc(-n2c3cc(S(=O)(=O)NC4(C#N)CC4)ccc3c3c(N4CCN(C(=O)C5CC5)CC4)ncnc32)s1	InChI=1S/C27H29N9O3S2/c1-16(2)24-31-32-26(40-24)36-20-13-18(41(38,39)33-27(14-28)7-8-27)5-6-19(20)21-22(29-15-30-23(21)36)34-9-11-35(12-10-34)25(37)17-3-4-17/h5-6,13,15-17,33H,3-4,7-12H2,1-2H3	JBVLFECRCGVTLP-UHFFFAOYSA-N	87325	US20250388589, Example 186	Poly(ADP-ribose) glycohydrolase	Homo sapiens		 550							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=87325	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=87325&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171461061	252659757							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124638	N#CC1(NS(=O)(=O)c2ccc3c4c(N5CCN(C(=O)C6CC6)CC5)ncnc4n(-c4nnc(C(F)(F)F)s4)c3c2)CC1	InChI=1S/C25H22F3N9O3S2/c26-25(27,28)22-32-33-23(41-22)37-17-11-15(42(39,40)34-24(12-29)5-6-24)3-4-16(17)18-19(30-13-31-20(18)37)35-7-9-36(10-8-35)21(38)14-1-2-14/h3-4,11,13-14,34H,1-2,5-10H2	RVUOOPQXTJLXQX-UHFFFAOYSA-N	87326	US20250388589, Example 188	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=87326	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=87326&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460761	252659758							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124639	N#CC1(NS(=O)(=O)c2ccc3c4c(N5CCC(O)CC5)ncnc4n(-c4nnc(C(F)F)s4)c3c2)CC1	InChI=1S/C22H20F2N8O3S2/c23-17(24)20-28-29-21(36-20)32-15-9-13(37(34,35)30-22(10-25)5-6-22)1-2-14(15)16-18(26-11-27-19(16)32)31-7-3-12(33)4-8-31/h1-2,9,11-12,17,30,33H,3-8H2	BSMJSDGGNKHJMM-UHFFFAOYSA-N	87327	US20250388589, Example 189	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=87327	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=87327&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460869	252659759							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124640	CC(C)C(=O)N1[C@H](C)CN(c2ncnc3c2c2ccc(S(=O)(=O)NC4(C)CC4)cc2n3-c2nnc(C(F)F)s2)C[C@@H]1C	InChI=1S/C27H32F2N8O3S2/c1-14(2)25(38)36-15(3)11-35(12-16(36)4)22-20-18-7-6-17(42(39,40)34-27(5)8-9-27)10-19(18)37(23(20)31-13-30-22)26-33-32-24(41-26)21(28)29/h6-7,10,13-16,21,34H,8-9,11-12H2,1-5H3	BPGKXJNUPOJNGZ-UHFFFAOYSA-N	87328	US20250388589, Example 190	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=87328	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=87328&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460703	252659760							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124641	N#CC1(N[S@SP1](=O)(=O)c2ccc3c4c(N5CCC(O)(C(F)(F)F)CC5)ncnc4n(-c4nnc(C(F)F)s4)c3c2)CC1	InChI=1S/C23H19F5N8O3S2/c24-16(25)19-32-33-20(40-19)36-14-9-12(41(38,39)34-21(10-29)3-4-21)1-2-13(14)15-17(30-11-31-18(15)36)35-7-5-22(37,6-8-35)23(26,27)28/h1-2,9,11,16,34,37H,3-8H2	MUIUVDQBFONZAR-UHFFFAOYSA-N	87329	US20250388589, Example 191	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=87329	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=87329&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171776925	252659761							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124642	Cc1nc(N2CCN3CCOC[C@H]3C2)c2c3ccc(S(=O)(=O)NC4(C#N)CC4)cc3n(-c3nnc(C(F)F)s3)c2n1	InChI=1S/C25H25F2N9O3S2/c1-14-29-21(35-7-6-34-8-9-39-12-15(34)11-35)19-17-3-2-16(41(37,38)33-25(13-28)4-5-25)10-18(17)36(22(19)30-14)24-32-31-23(40-24)20(26)27/h2-3,10,15,20,33H,4-9,11-12H2,1H3	PLKDISPXCADWII-UHFFFAOYSA-N	87330	US20250388589, Example 192	Poly(ADP-ribose) glycohydrolase	Homo sapiens		 550							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=87330	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=87330&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			170311377	252659762							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124643	C[C@@H]1CN(C)[C@@H](C)CN1c1ncnc2c1c1ccc(S(=O)(=O)NC3(C#N)CC3)cc1n2-c1nnc(C(F)F)s1	InChI=1S/C24H25F2N9O2S2/c1-13-10-34(14(2)9-33(13)3)20-18-16-5-4-15(39(36,37)32-24(11-27)6-7-24)8-17(16)35(21(18)29-12-28-20)23-31-30-22(38-23)19(25)26/h4-5,8,12-14,19,32H,6-7,9-10H2,1-3H3	BSEGRTJUMXJBCC-UHFFFAOYSA-N	87331	US20250388589, Example 193	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=87331	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=87331&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171461008	252659763							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124644	CN(C)C(=O)N1CC=C(c2ccnc3c2c2ccc(S(=O)(=O)NC4(C)CC4)cc2n3-c2nnc(C(F)F)s2)CC1	InChI=1S/C26H27F2N7O3S2/c1-26(9-10-26)32-40(37,38)16-4-5-18-19(14-16)35(24-31-30-23(39-24)21(27)28)22-20(18)17(6-11-29-22)15-7-12-34(13-8-15)25(36)33(2)3/h4-7,11,14,21,32H,8-10,12-13H2,1-3H3	STUHZSPCFFPKLB-UHFFFAOYSA-N	87332	US20250388589, Example 194	Poly(ADP-ribose) glycohydrolase	Homo sapiens		 550							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=87332	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=87332&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460909	252659764							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124645	CN(C)C(=O)N1CCC(c2ccnc3c2c2ccc(S(=O)(=O)NC4(C)CC4)cc2n3-c2nnc(C(F)F)s2)CC1	InChI=1S/C26H29F2N7O3S2/c1-26(9-10-26)32-40(37,38)16-4-5-18-19(14-16)35(24-31-30-23(39-24)21(27)28)22-20(18)17(6-11-29-22)15-7-12-34(13-8-15)25(36)33(2)3/h4-6,11,14-15,21,32H,7-10,12-13H2,1-3H3	XPMCOBBWUQOEJO-UHFFFAOYSA-N	87333	US20250388589, Example 195	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=87333	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=87333&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460884	252659765							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124646	CN(C)C(=O)N1CC=C(c2ccnc3c2c2ccc(S(=O)(=O)NC4(C#N)CC4)cc2n3-c2nnc(C(F)F)s2)CC1	InChI=1S/C26H24F2N8O3S2/c1-34(2)25(37)35-11-6-15(7-12-35)17-5-10-30-22-20(17)18-4-3-16(41(38,39)33-26(14-29)8-9-26)13-19(18)36(22)24-32-31-23(40-24)21(27)28/h3-6,10,13,21,33H,7-9,11-12H2,1-2H3	WFCLRBRLBCRHIR-UHFFFAOYSA-N	87334	US20250388589, Example 196	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=87334	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=87334&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460982	252659766							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124647	CC(C)C(=O)N1CCC(c2ccnc3c2c2ccc(S(=O)(=O)NC4(C#N)CC4)cc2n3-c2nnc(C(F)F)s2)CC1	InChI=1S/C27H27F2N7O3S2/c1-15(2)25(37)35-11-6-16(7-12-35)18-5-10-31-23-21(18)19-4-3-17(41(38,39)34-27(14-30)8-9-27)13-20(19)36(23)26-33-32-24(40-26)22(28)29/h3-5,10,13,15-16,22,34H,6-9,11-12H2,1-2H3	MDTCKCHFBBLGGP-UHFFFAOYSA-N	87335	US20250388589, Example 197	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=87335	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=87335&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460865	252659767							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124648	CN1CCN(c2ccnc3c2c2ccc(S(=O)(=O)NC4(C#N)CC4)cc2n3-c2nnc(C(F)F)s2)CC1	InChI=1S/C23H22F2N8O2S2/c1-31-8-10-32(11-9-31)16-4-7-27-20-18(16)15-3-2-14(37(34,35)30-23(13-26)5-6-23)12-17(15)33(20)22-29-28-21(36-22)19(24)25/h2-4,7,12,19,30H,5-6,8-11H2,1H3	URJGIXRLJKTZSW-UHFFFAOYSA-N	87336	US20250388589, Example 198	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=87336	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=87336&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171461043	252659768							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124649	C[C@@H]1COCCN1c1ncnc2c1c1ccc(S(=O)(=O)NC3(C#N)CC3)cc1n2-c1nnc(C(F)F)s1	InChI=1S/C22H20F2N8O3S2/c1-12-9-35-7-6-31(12)18-16-14-3-2-13(37(33,34)30-22(10-25)4-5-22)8-15(14)32(19(16)27-11-26-18)21-29-28-20(36-21)17(23)24/h2-3,8,11-12,17,30H,4-7,9H2,1H3	AWCLCQCNQZMXBH-UHFFFAOYSA-N	87337	US20250388589, Example 199	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=87337	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=87337&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			170311346	252659769							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124650	C[C@@H]1CO[C@@H](C)CN1c1ncnc2c1c1ccc(S(=O)(=O)NC3(C#N)CC3)cc1n2-c1nnc(C(F)F)s1	InChI=1S/C23H22F2N8O3S2/c1-12-9-36-13(2)8-32(12)19-17-15-4-3-14(38(34,35)31-23(10-26)5-6-23)7-16(15)33(20(17)28-11-27-19)22-30-29-21(37-22)18(24)25/h3-4,7,11-13,18,31H,5-6,8-9H2,1-2H3	XKVLAJXNALQDRK-UHFFFAOYSA-N	87338	US20250388589, Example 200	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=87338	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=87338&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460780	252659770							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124651	N#CC1(NS(=O)(=O)c2ccc3c4c(N5CC6CCC(C5)O6)ncnc4n(-c4nnc(C(F)F)s4)c3c2)CC1	InChI=1S/C23H20F2N8O3S2/c24-18(25)21-29-30-22(37-21)33-16-7-14(38(34,35)31-23(10-26)5-6-23)3-4-15(16)17-19(27-11-28-20(17)33)32-8-12-1-2-13(9-32)36-12/h3-4,7,11-13,18,31H,1-2,5-6,8-9H2	SIZVSGRYNYJPRZ-UHFFFAOYSA-N	87339	US20250388589, Example 201	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=87339	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=87339&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171461011	252659771							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124652	N#CC1(NS(=O)(=O)c2ccc3c4c(N5C[C@H]6C[C@@H]5CO6)ncnc4n(-c4nnc(C(F)F)s4)c3c2)CC1	InChI=1S/C22H18F2N8O3S2/c23-17(24)20-28-29-21(36-20)32-15-6-13(37(33,34)30-22(9-25)3-4-22)1-2-14(15)16-18(26-10-27-19(16)32)31-7-12-5-11(31)8-35-12/h1-2,6,10-12,17,30H,3-5,7-8H2	CCAYPOOOWTWYDY-UHFFFAOYSA-N	87340	US20250388589, Example 202	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=87340	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=87340&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171461051	252659772							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124653	CN1CCN(c2ncnc3c2c2ccc(S(=O)(=O)NC4(C#N)CC4)cc2n3-c2nnc(C(F)F)s2)C[C@@H]1CF	InChI=1S/C23H22F3N9O2S2/c1-33-6-7-34(10-13(33)9-24)19-17-15-3-2-14(39(36,37)32-23(11-27)4-5-23)8-16(15)35(20(17)29-12-28-19)22-31-30-21(38-22)18(25)26/h2-3,8,12-13,18,32H,4-7,9-10H2,1H3	OTYHPOSTARAVBL-UHFFFAOYSA-N	87342	US20250388589, Example 203	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=87342	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=87342&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			170311319	252659774							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125242	COC[C@H]1CN(c2ncnc3c2c2ccc(S(=O)(=O)NC4(C#N)CC4)cc2n3-c2nnc(C(F)F)s2)CCN1C	InChI=1S/C24H25F2N9O3S2/c1-33-7-8-34(10-14(33)11-38-2)20-18-16-4-3-15(40(36,37)32-24(12-27)5-6-24)9-17(16)35(21(18)29-13-28-20)23-31-30-22(39-23)19(25)26/h3-4,9,13-14,19,32H,5-8,10-11H2,1-2H3	LVZCLVKSGOYYMY-UHFFFAOYSA-N	87343	US20250388589, Example 204	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=87343	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=87343&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			170311372	252659775							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125243	C[C@H]1CN(c2ncnc3c2c2ccc(S(=O)(=O)NC4(C#N)CC4)cc2n3-c2nnc(C(F)F)s2)CCN1CC#N	InChI=1S/C24H22F2N10O2S2/c1-14-11-35(9-8-34(14)7-6-27)20-18-16-3-2-15(40(37,38)33-24(12-28)4-5-24)10-17(16)36(21(18)30-13-29-20)23-32-31-22(39-23)19(25)26/h2-3,10,13-14,19,33H,4-5,7-9,11H2,1H3	JPRAEGNQHBDFGK-UHFFFAOYSA-N	87344	US20250388589, Example 205	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=87344	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=87344&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			170311345	252659776							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125244	CCC(CC)N1CCN(c2ncnc3c2c2ccc(S(=O)(=O)NC4(C#N)CC4)cc2n3-c2nnc(C(F)F)s2)C[C@@H]1F	InChI=1S/C26H28F3N9O2S2/c1-3-15(4-2)37-10-9-36(12-19(37)27)22-20-17-6-5-16(42(39,40)35-26(13-30)7-8-26)11-18(17)38(23(20)32-14-31-22)25-34-33-24(41-25)21(28)29/h5-6,11,14-15,19,21,35H,3-4,7-10,12H2,1-2H3	ONFIKVRBZJMMGE-UHFFFAOYSA-N	87345	US20250388589, Example 206	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=87345	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=87345&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			178289679	252659777							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125245	N#CC1(NS(=O)(=O)c2ccc3c4c(N5CCC(N6CCCC6)[C@@H](F)C5)ncnc4n(-c4nnc(C(F)F)s4)c3c2)CC1	InChI=1S/C26H26F3N9O2S2/c27-17-12-37(10-5-18(17)36-8-1-2-9-36)22-20-16-4-3-15(42(39,40)35-26(13-30)6-7-26)11-19(16)38(23(20)32-14-31-22)25-34-33-24(41-25)21(28)29/h3-4,11,14,17-18,21,35H,1-2,5-10,12H2	NIFNKWSSWALMPF-UHFFFAOYSA-N	87346	US20250388589, Example 207	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=87346	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=87346&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460964	252659778							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125246	N#CC1(NS(=O)(=O)c2ccc3c4c(N5CCC(N6CCC6)[C@@H](F)C5)ncnc4n(-c4nnc(C(F)F)s4)c3c2)CC1	InChI=1S/C25H24F3N9O2S2/c26-16-11-36(9-4-17(16)35-7-1-8-35)21-19-15-3-2-14(41(38,39)34-25(12-29)5-6-25)10-18(15)37(22(19)31-13-30-21)24-33-32-23(40-24)20(27)28/h2-3,10,13,16-17,20,34H,1,4-9,11H2	NKJSEQHTWWVJGL-UHFFFAOYSA-N	87347	US20250388589, Example 208	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=87347	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=87347&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171460970	252659779							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125247	N#CC1(NS(=O)(=O)c2ccc3c4c(N5CCC(N6CCOCC6)[C@@H](F)C5)ncnc4n(-c4nnc(C(F)F)s4)c3c2)CC1	InChI=1S/C26H26F3N9O3S2/c27-17-12-37(6-3-18(17)36-7-9-41-10-8-36)22-20-16-2-1-15(43(39,40)35-26(13-30)4-5-26)11-19(16)38(23(20)32-14-31-22)25-34-33-24(42-25)21(28)29/h1-2,11,14,17-18,21,35H,3-10,12H2	LXWFSEATDVGVKQ-UHFFFAOYSA-N	87348	US20250388589, Example 209	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=87348	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=87348&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171461052	252659780							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
125248	N#CC1(NS(=O)(=O)c2ccc3c4c(N5C6CCC5COC6)ncnc4n(-c4nnc(C(F)F)s4)c3c2)CC1	InChI=1S/C23H20F2N8O3S2/c24-18(25)21-29-30-22(37-21)33-16-7-14(38(34,35)31-23(10-26)5-6-23)3-4-15(16)17-19(27-11-28-20(17)33)32-12-1-2-13(32)9-36-8-12/h3-4,7,11-13,18,31H,1-2,5-6,8-9H2	GONHDCJCGGDALR-UHFFFAOYSA-N	87349	US20250388589, Example 210	Poly(ADP-ribose) glycohydrolase	Homo sapiens		<0.0001							US Patent		10.7270/Q2ZK5NG6			US20250388589	ZHOU, W; ZHUO, J; ZHANG, Y; YU, Z; YAN, D	12/25/2025	5/6/2026	Danatlas Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=87349	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8592&target=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=87349&enzyme=Poly%28ADP-ribose%29+glycohydrolase&column=ki&startPg=0&Increment=50&submit=Search			171461033	252659781							1	MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT	6OAL,6OAK,6OA3,6OA1,6OA0,6O9Y,6O9X,5MAV	Poly(ADP-ribose) glycohydrolase	PARG_HUMAN	Q86W56	A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7